LOCUS       OW967605               13636 bp    DNA     circular BCT 22-MAY-2022
DEFINITION  Klebsiella pneumoniae isolate 512 genome assembly, plasmid: P4.
ACCESSION   OW967605
VERSION     OW967605.1
DBLINK      BioProject: PRJEB42440
            BioSample: SAMEA8065848
KEYWORDS    .
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1
  AUTHORS   Alioto,T., Alioto,T. and Gomez Garrido,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-MAY-2022) CNAG-CRG, CNAG, Spain
FEATURES             Location/Qualifiers
     source          1..13636
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
                     /isolate="512"
                     /isolation_source="Hospital Reina Sofia (Cordoba)"
                     /db_xref="taxon:573"
                     /plasmid="P4"
     gene            <72..1223
                     /locus_tag="AI2806V1_5435"
     mRNA            72..1223
                     /locus_tag="AI2806V1_5435"
                     /note="AI2806v1_5435.mrna"
     CDS             <72..1223
                     /locus_tag="AI2806V1_5435"
                     /note="short variant; AI2806v1_5435.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="CAH5530454.1"
                     /translation="VMATNALIRCVRDFGDAVVYFDPKGDAWAPHVFRAHCPDFTLLDL
                     RPGKPAQLNLFRDLDQYALKNLLIAGLNLGETGDVADHYRISEQKAAKLIAEQFPQGAN
                     IQQVLAAAYALPEALKKDVKGLITRLENVADLSVLQTDSGIDVAGIINGGGCLYVIGSM
                     DDEAVIRVQKMLFARCAQIIIARDEFREWPHVSVMLDEIKYLLSKYVLNALGTLRSRDC
                     NLLLAHQSLGDFGQCGQDLPAEFVKTTVLDNTPIRWFYRAASLESAQWAAGQTGEIRVD
                     VERRRASREAGNVEHISGDSFIQKEARPLFDVNTLQHLPDGFAVMTGLGVARMAFSSPL
                     RVERREIPLQRFPVLAKTDPLAEFRPPADGGGPKADDDFAGIY"
                     /name="hypothetical protein"
     exon            72..1223
                     /locus_tag="AI2806V1_5435"
                     /note="AI2806v1_5435.mrna"
                     /number=1
     gene            1223..1954
                     /locus_tag="AI2806V1_5436"
     mRNA            1223..1954
                     /locus_tag="AI2806V1_5436"
                     /note="AI2806v1_5436.mrna"
     CDS             1223..1954
                     /locus_tag="AI2806V1_5436"
                     /note="long variant; AI2806v1_5436.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="CAH5530571.1"
                     /translation="MALELYNVSHAKRQARNAEKTRLTLRWLREELCSTAELVARRLGI
                     AAVQPVYRFLDSLVAKGLLVRTKYPVDGRQVSVWGLTPHGVAFSFDEDEPLADVIPFQP
                     SRVSAAHLPHRLAVQSLRLDMEARGATGWRILHRLSLKGMKVPDALAELDGKTVAFEVE
                     RTVKSRRRYQEVVSGYLFNRKANGIDEIWYICPDRATQVRVQRAILSVDEIVNPQTGEA
                     RKTAELDRERLFACFKFMTTE"
                     /name="hypothetical protein"
     exon            1223..1954
                     /locus_tag="AI2806V1_5436"
                     /note="AI2806v1_5436.mrna"
                     /number=1
     gene            1961..2491
                     /locus_tag="AI2806V1_5437"
     mRNA            1961..2491
                     /locus_tag="AI2806V1_5437"
                     /note="AI2806v1_5437.mrna"
     CDS             1961..2491
                     /locus_tag="AI2806V1_5437"
                     /note="long variant; AI2806v1_5437.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="CAH5530684.1"
                     /translation="MALYMVFIEDAEDRNGERCIMPTSEHLEDMVVLAWQTGAYVFCFV
                     DRAQHLAMMKSIGMYDERLNSDEKATYFFTGKNPQWERNKPTGMKLCDYLYRKVERFAI
                     ENGVQVVDAGKCSPEQINAMIDVVSERHGESAVNEKLKAELMREYNSRYFNVPVPELPE
                     DKPARRWWPFGKK"
                     /name="hypothetical protein"
     exon            1961..2491
                     /locus_tag="AI2806V1_5437"
                     /note="AI2806v1_5437.mrna"
                     /number=1
     gene            complement(2519..2698)
                     /locus_tag="AI2806V1_5438"
     mRNA            complement(2519..2698)
                     /locus_tag="AI2806V1_5438"
                     /note="AI2806v1_5438.mrna"
     CDS             complement(2519..2698)
                     /locus_tag="AI2806V1_5438"
                     /note="long variant; AI2806v1_5438.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="Regulatory protein rop"
                     /protein_id="CAH5530800.1"
                     /translation="MTKQEKTALNMAKFIKEQSLLLLDKLNELDMDTPADMCERLHEDA
                     ETLWQVMRDKLGEE"
                     /name="Regulatory protein rop"
     exon            complement(2519..2698)
                     /locus_tag="AI2806V1_5438"
                     /note="AI2806v1_5438.mrna"
                     /number=1
     gene            2767..3144
                     /locus_tag="AI2806V1_5439"
     mRNA            2767..3144
                     /locus_tag="AI2806V1_5439"
                     /note="AI2806v1_5439.mrna"
     CDS             2767..3144
                     /locus_tag="AI2806V1_5439"
                     /note="long variant; AI2806v1_5439.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="CAH5530913.1"
                     /translation="MAWVTVRQATELTGKARSSLYRDMAKGRVSYRTEADGGRVVDTSE
                     LIRVYGELRQDETHERDELRLSGETEKMASDALIAEIKALREEVAGLRQEMQSMRLLEH
                     KPETAETPAGTPRRWWPWGKR"
                     /name="hypothetical protein"
     exon            2767..3144
                     /locus_tag="AI2806V1_5439"
                     /note="AI2806v1_5439.mrna"
                     /number=1
     gene            complement(3206..3505)
                     /locus_tag="AI2806V1_5440"
     mRNA            complement(3206..3505)
                     /locus_tag="AI2806V1_5440"
                     /note="AI2806v1_5440.mrna"
     CDS             complement(3206..3505)
                     /locus_tag="AI2806V1_5440"
                     /note="long variant; AI2806v1_5440.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="CAH5531031.1"
                     /translation="MPYDVEWKQGAIEDVTTLFDYIAENSSLWDAQNVTDRVLAAADKL
                     ADFPRLYEVDSRYGEDVRRISLMGQHVLYDVDDQTRKVRVLAVVGQRQNPHIVL"
                     /name="hypothetical protein"
     exon            complement(3206..3505)
                     /locus_tag="AI2806V1_5440"
                     /note="AI2806v1_5440.mrna"
                     /number=1
     gene            complement(3495..3758)
                     /locus_tag="AI2806V1_5441"
     mRNA            complement(3495..3758)
                     /locus_tag="AI2806V1_5441"
                     /note="AI2806v1_5441.mrna"
     CDS             complement(3495..3758)
                     /locus_tag="AI2806V1_5441"
                     /note="long variant; AI2806v1_5441.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="CAH5531140.1"
                     /translation="MSNTTHYENANFLRELAESLPRILPEGGPDKAALLQRLANEELAQ
                     AEYEDQVRAKVTAARADTRPGMTTEQLRQRLHGRYQELRDAV"
                     /name="hypothetical protein"
     exon            complement(3495..3758)
                     /locus_tag="AI2806V1_5441"
                     /note="AI2806v1_5441.mrna"
                     /number=1
     gene            complement(4064..>4396)
                     /locus_tag="AI2806V1_5442"
     mRNA            complement(4064..4396)
                     /locus_tag="AI2806V1_5442"
                     /note="AI2806v1_5442.mrna"
     CDS             complement(4064..>4396)
                     /locus_tag="AI2806V1_5442"
                     /note="short variant; AI2806v1_5442.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="CAH5531253.1"
                     /translation="LLNVSFRSTERQTPFDPNFSTQKADTTRMMVPFFRQFWDMGAKDK
                     ATGKSRSDVQQRIQQFHSQEFLNSLQGTTQFAGTDYRSKDLTPKKSRLLADTISAVYLD
                     GYEGRQ"
                     /name="hypothetical protein"
     exon            complement(4064..4396)
                     /locus_tag="AI2806V1_5442"
                     /note="AI2806v1_5442.mrna"
                     /number=1
     gene            complement(4389..7394)
                     /locus_tag="AI2806V1_5443"
     mRNA            complement(4389..7394)
                     /locus_tag="AI2806V1_5443"
                     /note="AI2806v1_5443.mrna"
     CDS             complement(4389..7394)
                     /locus_tag="AI2806V1_5443"
                     /note="long variant; AI2806v1_5443.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="CAH5531372.1"
                     /translation="MPVDFLTTEQVESYGRFTGEPDELQLARYFHLDEADKEFIGKSRG
                     DHNRLGIALQIGCVRFLGTFLTDMNHIPSGVRHFTARQLGIRDITVLAEYGQRENTRRE
                     HAALIRQHYQYREFAWPWTFRLTRLLYTRSWISNERPGLLFDLATGWLMQHRIILPGAT
                     TLTRLISEVREKATLRLWNKLALIPSAEQRSQLEMLLGPTDCSRLSLLESLKKGPVTIS
                     GPAFNEAIERWKTLNDFGLHAENLSTLPAVRLKNLARYAGMTSVFNIARMSPQKRMAVL
                     VAFVLAWETLALDDALDVLDAMLAVIIRDARKIGQKKRLRSLKDLDKSALALASACSYL
                     LKEETPDESIRAEVFSYIPRQKLAEIITLVREIARPSDDNFHDEMVEQYGRVRRFLPHL
                     LNTVKFSSAPAGVTTLNACDYLSREFSSRRQFFDDAPTEIISQSWKRLVINKEKHITRR
                     GYTLCFLSKLQDSLRRRDVYVTGSNRWGDPRARLLQGADWQANRIKVYRSLGHPTDPQE
                     AIKSLGHQLDSRYRQVAARLGENEAVELDVSGPKPRLTISPLASLDEPDSLKRLSKMIS
                     DLLPPVDLTELLLEINAHTGFADEFFHASEASARVDDLPVSISAVLMAEACNIGLEPLI
                     RSNVPALTRHRLNWTKANYLRAETITSANARLVDFQATLPLAQIWGGGEVASADGMRFV
                     TPVRTINAGPNRKYFGNNRGITWYNFVSDQYSGFHGIVIPGTLRDSIFVLEGLLEQETG
                     LNPTEIMTDTAGASDLVFGLFWLLGYQFSPRLADAGASVFWRMDHDADYGVLNDIARGQ
                     SDPRKIVLQWDEMIRTAGSLKLGKVQASVLVRSLLKSERPSGLTQAIIEVGRINKTLYL
                     LNYIDDEDYRRRILTQLNRGESRHAVARAICHGQKGEIRKRYTDGQEDQLGALGLVTNA
                     VVLWNTIYMQAALDHLRAQGETLNDEDIARLSPLCHGHINMLGHYSFTLAELVTKGHLR
                     PLKEASEAENVA"
                     /name="hypothetical protein"
     exon            complement(4389..7394)
                     /locus_tag="AI2806V1_5443"
                     /note="AI2806v1_5443.mrna"
                     /number=1
     gene            7556..8113
                     /locus_tag="AI2806V1_5444"
     mRNA            7556..8113
                     /locus_tag="AI2806V1_5444"
                     /note="AI2806v1_5444.mrna"
     CDS             7556..8113
                     /locus_tag="AI2806V1_5444"
                     /note="long variant; AI2806v1_5444.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="Transposon Tn3 resolvase"
                     /protein_id="CAH5531494.1"
                     /translation="MRIFGYARVSTSQQSLDIQIRALKDAGVKANRIFTDKASGSSTDR
                     EGLDLLRMKVEEGDVILVKKLDRLGRDTADMIQLIKEFDAQGVAVRFIDDGISTDGDMG
                     QMVVTILSAVAQAERRRILERTNEGRQEAKLKGIKFGRRRTVDRNVVLTLHQKGTGATE
                     IAHQLSIARSTVYKILEDERAS"
                     /name="Transposon Tn3 resolvase"
     exon            7556..8113
                     /locus_tag="AI2806V1_5444"
                     /note="AI2806v1_5444.mrna"
                     /number=1
     gene            8296..8901
                     /locus_tag="AI2806V1_5445"
     mRNA            8296..8901
                     /locus_tag="AI2806V1_5445"
                     /note="AI2806v1_5445.mrna"
     CDS             8296..8901
                     /locus_tag="AI2806V1_5445"
                     /note="long variant; AI2806v1_5445.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="Aminoglycoside N(6')-acetyltransferase type 1"
                     /protein_id="CAH5531601.1"
                     /translation="MSIQHFQTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRS
                     HIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGW
                     WEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAI
                     RCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSVA"
                     /name="Aminoglycoside N(6')-acetyltransferase type 1"
     exon            8296..8901
                     /locus_tag="AI2806V1_5445"
                     /note="AI2806v1_5445.mrna"
                     /number=1
     gene            <8983..9240
                     /locus_tag="AI2806V1_5446"
     mRNA            8983..9240
                     /locus_tag="AI2806V1_5446"
                     /note="AI2806v1_5446.mrna"
     CDS             <8983..9240
                     /locus_tag="AI2806V1_5446"
                     /note="short variant; AI2806v1_5446.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="Streptomycin 3''-adenylyltransferase"
                     /protein_id="CAH5531712.1"
                     /translation="VIAEVSTQLSEVVGVIERHLEPTLLAVHLYGSAVDGGLKPHSDID
                     LLVTVTVRLDETTRRALINDLLETALLQIVGGDKLIIPFC"
                     /name="Streptomycin 3''-adenylyltransferase"
     exon            8983..9240
                     /locus_tag="AI2806V1_5446"
                     /note="AI2806v1_5446.mrna"
                     /number=1
     gene            9252..9956
                     /locus_tag="AI2806V1_5447"
     mRNA            9252..9956
                     /locus_tag="AI2806V1_5447"
                     /note="AI2806v1_5447.mrna"
     CDS             9252..9956
                     /locus_tag="AI2806V1_5447"
                     /note="long variant; AI2806v1_5447.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="CAH5531759.1"
                     /translation="MNPFKGRHFQRDIIRWAVRWYCKYGISYRELQEMLAERGVNVDHS
                     TIYRWVQRYAPEMEKRLRWYWRNPSDLCPWHMDETYVKVNGRWAYLYRAVDSRGRTVDF
                     YLSSRRNSKAAYRFLGKILNNVKKWQIPRFINTDKAPAYGRALALLKREGRCPSDVEHR
                     QIKYRNNVIECDHGKLKRIIGATLGFKSMKTAYATIKGIEVMRALRKGQASAFYYGDPL
                     GEMRLVSRVFEM"
                     /name="hypothetical protein"
     exon            9252..9956
                     /locus_tag="AI2806V1_5447"
                     /note="AI2806v1_5447.mrna"
                     /number=1
     gene            <10377..10913
                     /locus_tag="AI2806V1_5448"
     mRNA            10377..10913
                     /locus_tag="AI2806V1_5448"
                     /note="AI2806v1_5448.mrna"
     CDS             <10377..10913
                     /locus_tag="AI2806V1_5448"
                     /note="short variant; AI2806v1_5448.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="Colicin-E3"
                     /protein_id="CAH5531886.1"
                     /translation="VTYNPPHEYGSGWQDQVRYLDKDIQNQNEKLKAAQTSLNEMNESL
                     SRDKAALSGAMESRKQKEKKAKDAENKLNEEKKKPRKGTKDYGHDYFPDPKTEDIKGLG
                     ELKEGKPKTPKQGGGGKRARWYGDKKRKIYEWDSQHGELEGYRASDGEHLGAFDPKTGK
                     QVKGPDPKRNIKKYL"
                     /name="Colicin-E3"
     exon            10377..10913
                     /locus_tag="AI2806V1_5448"
                     /note="AI2806v1_5448.mrna"
                     /number=1
     gene            10923..11180
                     /locus_tag="AI2806V1_5449"
     mRNA            10923..11180
                     /locus_tag="AI2806V1_5449"
                     /note="AI2806v1_5449.mrna"
     CDS             10923..11180
                     /locus_tag="AI2806V1_5449"
                     /note="long variant; AI2806v1_5449.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="Colicin-E3 immunity protein"
                     /protein_id="CAH5531995.1"
                     /translation="MGLKLHIHWFDKKTEEFKGGEYSKDFGDDGSVIESLGMPLKDNIN
                     NGWFDVEKSWVSILQPHFKNVIDISKFDYFVSFVYRDGNW"
                     /name="Colicin-E3 immunity protein"
     exon            10923..11180
                     /locus_tag="AI2806V1_5449"
                     /note="AI2806v1_5449.mrna"
                     /number=1
     gene            12055..12183
                     /locus_tag="AI2806V1_5450"
     mRNA            12055..12183
                     /locus_tag="AI2806V1_5450"
                     /note="AI2806v1_5450.mrna"
     CDS             12055..12183
                     /locus_tag="AI2806V1_5450"
                     /note="long variant; AI2806v1_5450.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="CAH5532110.1"
                     /translation="MEKRHLRGLAVLPHMLVPCLFTESVGNFACVRSARRSLTAGA"
                     /name="hypothetical protein"
     exon            12055..12183
                     /locus_tag="AI2806V1_5450"
                     /note="AI2806v1_5450.mrna"
                     /number=1
     ARG             8348..8898
                     /name="aac(6')-Ib"
                     /gene="aac(6')-Ib"
                     /gene_name="AAC(6')-Ib family aminoglycoside
                     6'-N-acetyltransferase"
                     /tool="amrfinderplus"
                     /drug_class="AMINOGLYCOSIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             8984..9240
                     /name="aadA15"
                     /gene="aadA15"
                     /gene_name="ANT(3'')"
                     /tool="rgi"
                     /drug_class="aminoglycoside antibiotic"
                     /identity="97.14"
                     /coverage="32.32"
     ARG             8297..8901
                     /name="AAC(6')-Ib10"
                     /gene="AAC(6')-Ib10"
                     /gene_name="AAC(6')"
                     /tool="rgi"
                     /drug_class="aminoglycoside antibiotic"
                     /identity="98.97"
                     /coverage="99.01"
     Typing          complement(11518..12096)
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="95.361"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          1224..1951
                     /name="MOBC"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="1.34e-150"
ORIGIN
        1 tgctggttcc gcgtgatacc tggcgcaaga ccaacattca gatcctcggc ctgcccggga
       61 gcggcaagag cgtgatggcc accaacgcgc tcattcgctg cgtacgcgat ttcggggacg
      121 cggtggtgta cttcgacccc aaaggggacg catgggcgcc gcacgtcttc cgggcgcact
      181 gtccggactt caccctgctg gatctgcggc cggggaaacc ggcgcagctg aatctgttcc
      241 gcgatctcga ccagtacgcg ctgaaaaacc tgctgattgc cgggcttaac ctgggcgaga
      301 ccggcgacgt ggcggaccac taccgcatca gcgagcagaa agcggcgaag ctgattgcgg
      361 agcagtttcc gcagggggca aacattcagc aggtgctggc ggcggcgtac gcgctgccgg
      421 aggccctgaa aaaggacgtg aaggggttga tcactaggct ggaaaacgtc gctgacctga
      481 gcgtcctgca gacggacagt ggcatcgatg tggcggggat tatcaacggc ggcggctgcc
      541 tgtacgttat cggctcgatg gacgacgagg cggtgatccg tgtgcaaaaa atgctgtttg
      601 cccgctgcgc gcaaatcatc attgcgcggg acgagttccg ggagtggcca cacgtcagcg
      661 tgatgctcga tgaaattaaa tatctgctgt cgaagtatgt actgaacgca ctggggacgc
      721 tgcgcagccg ggactgcaat ctgttgctcg cgcaccagtc gctgggcgat ttcgggcagt
      781 gcgggcagga tctgcccgct gaatttgtga aaaccacggt actggataac acgccgatcc
      841 gctggtttta ccgggcggcc agcctggagt ccgcgcagtg ggcggcgggg cagaccgggg
      901 aaatcagggt ggacgtggag cgccgccgtg ccagccggga ggcggggaac gtggagcata
      961 tcagcgggga cagcttcatc cagaaggagg cgcggccgct gtttgacgtg aacaccctgc
     1021 aacacctgcc ggacgggttc gcggtcatga ccgggctggg tgtggcccgg atggcgttca
     1081 gcagtccgct gcgggttgag cgccgggaaa tcccgttgca gcgtttcccg gtgctggcga
     1141 aaaccgatcc cctggcggag ttccggcccc cggccgacgg cggcgggccg aaagcggatg
     1201 atgattttgc ggggatttac tgatggcgct ggagctgtac aacgtcagcc acgcgaaacg
     1261 acaggcgcgg aacgcggaga aaacccggct gaccctgcgc tggttgcggg aagagctgtg
     1321 ttccacggcg gagctggttg cgcggcggct ggggattgcg gcggtgcagc cggtctaccg
     1381 cttcctcgac agcctggtgg cgaaagggct gctggtccgg accaaatatc cggtggacgg
     1441 ccgtcaggtc agcgtgtggg ggctgacgcc gcatggcgtg gcgttctcgt tcgacgagga
     1501 cgaaccgctg gcggatgtta ttccgtttca gccgtcaagg gtgtcggcag cacatctgcc
     1561 gcaccggctg gccgtgcaat ccctgcgcct tgatatggaa gccagagggg ccaccggctg
     1621 gcgcattctg caccgtctga gtcttaaagg catgaaagtg ccggacgccc tggcggagct
     1681 ggacggtaaa acggtggcgt ttgaggtgga gcgcaccgtc aagagccgtc gccggtatca
     1741 ggaagtggtg tccgggtatc tgttcaaccg caaagctaac ggcatcgatg aaatctggta
     1801 catctgcccg gaccgggcga cgcaggtcag ggtgcagcgg gcaatcctgt cggtggatga
     1861 aatcgtgaac ccacagaccg gcgaggcccg caaaacggca gagctggatc gtgaacggtt
     1921 gtttgcgtgc tttaaattta tgacaacgga gtgagggatt atggcgctgt acatggtatt
     1981 tattgaagac gcggaggacc ggaacggcga gcgctgcatc atgccgacca gcgagcatct
     2041 ggaagatatg gtggtgctcg cctggcagac cggggcgtat gttttctgtt ttgtcgaccg
     2101 ggcccagcat ctggcgatga tgaaatccat cgggatgtat gacgagcggc tcaacagcga
     2161 cgaaaaagcc acgtactttt tcactggtaa aaatccgcaa tgggaacgga acaaacccac
     2221 aggaatgaag ctgtgtgatt acctctatcg caaggtggag cggttcgcca tcgagaacgg
     2281 tgtgcaggtg gttgatgccg ggaagtgctc accggagcag attaacgcga tgattgacgt
     2341 ggtgagtgag cggcacgggg aaagcgcggt gaacgagaag ctgaaagcgg agctgatgcg
     2401 ggaatataac agccgctatt ttaacgtgcc ggtacctgaa ctgccggagg acaaacctgc
     2461 ccgccggtgg tggccgttcg gcaaaaaata aatgccagca ccggccatgc cggtgctgtt
     2521 attcctcccc gagcttatcc cgcatcacct gccagagtgt ttccgcatcc tcgtgtagcc
     2581 gctcgcacat gtcggccggg gtatccatat ccagctcatt cagtttatcg agcaatagca
     2641 gcgactgctc cttaataaat ttagccatat tgagggctgt tttttcctgt tttgtcatga
     2701 ttctttcctt ccgggcatgg tgtgcgcctg tcaggtatac tgtctcaaaa atagcggggt
     2761 gagacaatgg cgtgggtgac ggtgagacag gcgacggaac tgacgggtaa agcccgaagt
     2821 tccctgtatc gggatatggc gaaaggccgc gtatcatacc gtacggaagc tgatggcggc
     2881 cgggtggtgg ataccagcga gcttatccgg gtgtacggtg agttaagaca ggatgagact
     2941 cacgagcggg acgagttgag actgtcgggt gagactgaaa aaatggcctc cgacgcgttg
     3001 atcgcggaga taaaagcact cagggaggag gtggccgggc tacggcagga aatgcagtcc
     3061 atgagactgc tggaacacaa accggagaca gcagagaccc cggccggaac accgcgccgg
     3121 tggtggccgt ggggaaaacg ctgacgcgct gtgcttgtcc aaccggcgac ggccacgcaa
     3181 tgaattgcgt ccccgtcacc ggttattaga gaacaatatg gggattctgg cgctggccga
     3241 ccacggccag aacccggact tttctggtct ggtcatcaac atcatagagg acatgctgtc
     3301 ccatcagact gatccggcga acgtcctcgc catagcgtga gtccacttca tagagtcgcg
     3361 ggaagtcggc cagtttgtcc gccgcagcga gaacccggtc ggtaacgttc tgcgcatccc
     3421 acagggatga attttccgcg atatagtcaa acagcgtcgt tacatcctcg atggctccct
     3481 gcttccattc cacgtcatac ggcatcgcgc agttcctgat aacggccatg caggcgctgg
     3541 cggagttgtt ccgtggtcat acccggacgc gtgtcagcac gggcggcggt cactttggcg
     3601 cgaacctgat cttcatactc tgcctgggcc agttcttcgt tagccagtcg ctgcaacagc
     3661 gcagctttgt ccgggccacc ttccggcagt atgcggggca ggctttcagc cagttcccga
     3721 agaaagttgg cgttttcgta gtgtgtagtg ttgctcattg cggagcctcc cgggttaatg
     3781 cggcaatatg aaggaagttt agcagggggc ggtctgaaag aatatggtcg tgtcagtcag
     3841 gctgatgaag cagaaagtcg gtaaaaaagg gcttacggca tccattttac gtcaaaacat
     3901 atgccatgca gttgcgtgca taggcatgca ttaggataaa atttatcggg cgcgtttccg
     3961 gcagttttcc gggggggttg ttgcctgttt tatcccgtag ccgccggaaa cgccctgagc
     4021 ccgtctgagc ggtgcgcgta atgacgcgtt atggtaaatc cacttactgt ctgccttcat
     4081 agccatcgag ataaacagct gaaatggtgt cagccagtag ccttgatttt ttcggtgtga
     4141 ggtctttgct gcggtaatcg gtacccgcaa attgtgttgt gccttggagt gagtttaaaa
     4201 attcctgact gtgaaactgc tgaatgcgtt gctgcacatc actccgtgat tttccggtcg
     4261 ctttatcctt tgcgcccata tcccagaact gccggaaaaa aggcaccatc attcgtgttg
     4321 tgtcagcttt ctgggtggaa aaattgggat caaaaggggt ctgacgctca gtggaacgaa
     4381 aactcacgtt aagcaacgtt ttctgcctct gacgcctctt ttaatggtct cagatgacct
     4441 ttggtcacca gttctgccag cgtgaaggaa taatggccga gcatattgat atgtccgtgg
     4501 caaagcgggg agaggcgtgc gatatcttca tcattcagtg tttcaccctg cgcccggaga
     4561 tgatccagag ctgcctgcat ataaatagtg ttccataaca cgacggcgtt agtgaccagc
     4621 cccagagctc ccaactgatc ttcctgaccg tcggtatatc gttttcttat ctcacctttt
     4681 tgaccgtgac agatggctct ggcaactgca tgacggcttt ctccccgatt aagctgggtc
     4741 agaatgcgcc ggcggtaatc ttcatcatca atataattaa gcagatacag cgttttgttg
     4801 atgcgcccca cttcaatgat tgcctgagtc agtccggagg gacgttcact tttcagcaat
     4861 gaacggacca gcactgaggc ctgtactttg cccagcttca gggagcctgc ggtccggatc
     4921 atttcgtccc actgaaggac tatttttcgg ggatctgatt gccctctggc aatatcattc
     4981 agcacgccat agtcggcatc atggtccatt cgccagaaaa ccgaagcacc ggcatcagcc
     5041 aggcgtggag aaaactggta tcccagcagc cagaaaaggc caaagacaag atcgctggca
     5101 cctgccgtat cggtcataat ttcggttgga ttcagcccgg tctcctgttc cagaaggcct
     5161 tccagcacaa agatagagtc cctcagcgtc cccggtataa cgatgccatg aaagccggaa
     5221 tactgatcgg acacaaagtt gtaccaggtg atccctctgt tattaccaaa gtatttgcgg
     5281 ttcggtccgg cattgattgt tctgactggc gtaacaaagc gcattccatc tgcagatgcc
     5341 acttctcctc caccccatat ctgtgccagt ggcagcgttg cctgaaaatc aaccagtctg
     5401 gcattagcgc tggtgatagt ttcagcccgc agatagttcg cttttgtcca gttcagccgg
     5461 tgtcgggtca gtgcaggaac atttgatctg atcagtggtt ccagaccgat attgcaggct
     5521 tcagccatca gcacggcgct gatgctgacg ggcagatcat caactctggc actggcttca
     5581 ctggcatgga aaaactcatc agcaaatccg gtatgggcgt taatttcgag cagcaactcc
     5641 gttaaatcca ccggagggag cagatcactg atcattttgc tcagtcgttt cagactgtcc
     5701 ggctcatcaa gactggcgag gggagaaatt gtcaaccggg gcttcgggcc agaaacatcg
     5761 agttcgacag cctcattttc gccaagacgt gcagcaacct gtctgtaacg actatcaagc
     5821 tgatggccca gagattttat tgcttcctgc gggtctgtcg ggtgccccaa agaacgataa
     5881 accttaatcc gatttgcctg ccagtcagca ccctgtagta atcttgcacg aggatctccc
     5941 caccggttac tgccggtaac gtagacatcc ctccgtctca gactatcctg cagtttactg
     6001 agaaagcaga gcgtgtatcc ccttcgggtg atatgttttt ccttgttaat caccagccgt
     6061 ttccatgact gactgatgat ttccgttggt gcgtcgtcaa aaaactgccg ccgtgagctg
     6121 aactcccggc tgaggtagtc acaggcattc agagtggtaa ccccggcagg tgcggatgaa
     6181 aatttaacgg tattcagcag atggggcagg aaacgacgaa cgcgcccgta ctgctccacc
     6241 atttcgtcat gaaaattatc gtctgagggc cgggcaattt cacggacaag cgtgatgatt
     6301 tcagccagct tttgcctagg gatgtagctg aacacctcag cacgaatcga ttcgtccggt
     6361 gtttcttctt tcagcaagta cgaacatgcg ctggcgagcg ccaatgcaga tttatccaga
     6421 tccttcagcg agcggagccg ttttttctgc ccaatctttc tggcgtcacg gatgataacg
     6481 gccagcatgg cgtccagaac gtccagtgca tcatccagcg ccagcgtttc ccatgcaagg
     6541 acaaaggcaa ccagaaccgc catccttttc tgcggtgaca tcctggcaat attgaacacc
     6601 gaagtcatac cagcataacg tgcgagattt ttcaggcgca cagccgggag tgtactcagg
     6661 ttttcagcat gcaggccaaa atcgttcaga gttttccagc gttcaattgc ttcattaaac
     6721 gccggaccac tgatggtcac agggcctttt ttcagtgatt ccagtaaaga caggcggctg
     6781 caatcagttg gccccagcag catctccagc tgtgaacgct gttcggctga cggtatcagt
     6841 gccagtttgt tccacaggcg caacgtcgcc ttttccctta cctctgaaat caaccgggtc
     6901 agcgtggtgg ctccggggag aataatacga tgttgcataa gccaccctgt cgccaggtcg
     6961 aaaagcaggc caggacgttc gttgcttatc cagctccggg tatataaaag acgggtaagg
     7021 cgaaatgtcc agggccaggc aaattcacga tactgatagt gctgacgtat cagcgctgca
     7081 tgctcacggc gggtattttc cctctgaccg tattctgcaa gaacggtgat atcacgaatc
     7141 ccgagctgtc tggcggtaaa atgccggacg ccggaaggaa tatgattcat gtcagtaaga
     7201 aaagtgccca gaaaacgcac acacccgatt tgcagggcaa taccaagtcg attgtgatca
     7261 ccccggcttt tcccgataaa ttctttatcc gcttcatcaa gatgaaaata acgcgccagc
     7321 tgaagttcat cgggttcgcc agtgaacctg ccataactct caacctgctc agtggtcaaa
     7381 aaatcaacgg gcatatcggc ctccctgcct gacggctttt ttaacacaac tgcaaccgtt
     7441 cgaaatatta taaattatca gacatagtaa aacggcttcg tttgagtgtc cattaaatcg
     7501 tcattttggc ataatagaca catcgtgtct gatattcgat ttaaggtaca tttttatgcg
     7561 aatttttggt tatgcgcggg tctcaaccag ccagcagtcc ctcgatattc agatcagagc
     7621 gctcaaagat gcaggggtaa aagctaaccg catctttacc gacaaggcat ccggcagttc
     7681 aacagatcgg gaagggctgg atttgctgag gatgaaggtg gaggaaggtg atgtcattct
     7741 ggtgaagaag ctcgaccgtc ttggccgcga caccgccgac atgatccaac tgataaaaga
     7801 gtttgatgct cagggtgtag cggttcggtt tattgacgac gggatcagta ccgacggtga
     7861 tatggggcaa atggtggtca ccatcctgtc ggctgtggca caggctgaac gccggaggat
     7921 cctagagcgc acgaatgagg gccgacagga agcaaagctg aaaggaatca aatttggccg
     7981 caggcgtacc gtggacagga acgtcgtgct gacgcttcat cagaagggca ctggtgcaac
     8041 ggaaattgct catcagctca gtattgcccg ctccacggtt tataaaattc ttgaagacga
     8101 aagggcctcg tgatacgcct atttttatag gttaatgtca tgataataat ggtttcttag
     8161 acgtcaggtg gcacttttcg gggaaaagtg cgcggaaccc ctatttgttt atttttctaa
     8221 atacattcaa atatgtatcc gctcatgaga caataaccct gataaatgct tcaataatat
     8281 tgaaaaagga agagtatgag tattcaacat ttccaaacaa agttaggcat cacaaagtac
     8341 agcatcgtga ccaacagcaa cgattccgtc acactgcgcc tcatgactga gcatgacctt
     8401 gcgatgctct atgagtggct aaatcgatct catatcgtcg agtggtgggg cggagaagaa
     8461 gcacgcccga cacttgctga cgtacaggaa cagtacttgc caagcgtttt agcgcaagag
     8521 tccgtcactc catacattgc aatgctgaat ggagagccga ttgggtatgc ccagtcgtac
     8581 gttgctcttg gaagcgggga cggatggtgg gaagaagaaa ccgatccagg agtacgcgga
     8641 atagaccagt tactggcgaa tgcatcacaa ctgggcaaag gcttgggaac caagctggtt
     8701 cgagctctgg ttgagttgct gttcaatgat cccgaggtca ccaagatcca aacggacccg
     8761 tcgccgagca acttgcgagc gatccgatgc tacgagaaag cggggtttga gaggcaaggt
     8821 accgtaacca ccccagatgg tccagccgtg tacatggttc aaacacgcca ggcattcgag
     8881 cgaacacgca gtgttgccta acccttccat cgagggggac gtccaagggc tggcgccctt
     8941 ggccgcccct catgtcaaac gttaaacatc atgagggaag cggtgatcgc cgaagtatcg
     9001 actcaactat cagaggtagt tggcgtcatc gagcgccatc tcgaaccgac gttgctggcc
     9061 gtacatttgt acggctccgc agtggatggc ggcctgaagc cacacagtga tattgatttg
     9121 ctggttacgg tgaccgtaag gcttgatgaa acaacgcggc gagctttgat caacgacctt
     9181 ttggaaacgg cactgttgca aatagtcggt ggtgataaac ttatcatccc cttttgctga
     9241 tggagctgca catgaaccca ttcaaaggcc ggcattttca gcgtgacatc attcggtggg
     9301 ccgtacgctg gtactgcaaa tacggcatca gttaccgtga gctgcaggag atgctggctg
     9361 aacgcggagt gaatgtcgat cactccacga tttaccgctg ggttcagcgt tatgcgcctg
     9421 aaatggaaaa acggctgcgc tggtactggc gtaacccttc cgatctttgc ccgtggcaca
     9481 tggatgaaac ctacgtgaag gtcaatggcc gctgggcgta tctgtaccgg gccgtcgaca
     9541 gccggggccg cactgtcgat ttttatctct cctcccgtcg taacagcaaa gctgcatacc
     9601 ggtttctggg taaaatcctc aacaacgtga agaagtggca gatcccgcga ttcatcaaca
     9661 cggataaagc gcccgcctat ggtcgcgcgc ttgctctgct caaacgcgaa ggccggtgcc
     9721 cgtctgacgt tgaacaccga cagattaagt accggaacaa cgtgattgaa tgcgatcatg
     9781 gcaaactgaa acggataatc ggcgccacgc tgggatttaa atccatgaag acggcttacg
     9841 ccaccatcaa aggtattgag gtgatgcgtg cactacgcaa aggccaggcc tcagcatttt
     9901 attatggtga tcccctgggc gaaatgcgcc tggtaagcag agtttttgaa atgtaaggcc
     9961 tttgaataag acaaaaggct gcctcatcgc taactttgca acagtgccct gataaatctg
    10021 gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct
    10081 cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac
    10141 agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac caagtttact
    10201 catatatact ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga
    10261 tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt
    10321 cagaccccga agccgataaa aaggtaaaag aggcagaggc aaataaagat gattttgtga
    10381 cttataaccc gcctcatgaa tatggctccg ggtggcagga tcaggttcgc tatcttgata
    10441 aggatattca gaatcagaat gagaaattaa aagctgccca gacatcttta aacgaaatga
    10501 atgaatcctt atccagggat aaggctgcgc tttccggggc gatggagagc cggaaacaaa
    10561 aggagaaaaa agcgaaggat gcagaaaata aattaaatga ggaaaagaaa aaacctcgta
    10621 agggaactaa agattacggc catgattatt ttcctgatcc caagactgaa gatattaagg
    10681 ggttgggaga gttgaaagag ggtaaaccta aaacccctaa acaaggtggt ggtggtaagc
    10741 gggcccgatg gtatggtgat aaaaagcgta aaatttatga atgggattcc cagcacggtg
    10801 agcttgaagg gtaccgcgcc agtgatggcg aacacctcgg ggcattcgat ccaaaaacgg
    10861 gtaagcaggt taaagggccg gatccaaaac gaaacattaa aaaatatctt taagaggtaa
    10921 atatggggct taaattacat attcattggt ttgataagaa aaccgaagag tttaaaggtg
    10981 gtgaatactc aaaagacttc ggtgatgatg gttctgtcat tgaaagtctg gggatgcctt
    11041 taaaggataa tattaataat ggttggtttg atgttgaaaa atcatgggtt tcgatattac
    11101 agccacactt taaaaatgta atcgatatta gtaaatttga ttactttgta tcctttgttt
    11161 accgggatgg taactggtaa gcaaaagtta tcaaggatga tttgaaatac agacttccgg
    11221 tgttcaggga tgaataccgg ggtttttaaa tacagggaag gtatatgaaa aaggtaaagg
    11281 ttgtttttct ttttatattg attttttcag gctttcttct ggtcgcatgt caggcaaact
    11341 atatccggga tgttcagggt ggaacggtgg caccatcgtc ctcctctgaa ctgacgggga
    11401 tcgcggttca gtagaaaaga tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat
    11461 cttttgccct gtaaacgaaa aaaccacctg gggaggtggt ttgatcgaag gttaagtcag
    11521 ttggggaact gcttaaccgt ggtaactggc tttcgcagag cacagcaacc aaatctgtcc
    11581 ttccagtgta gccggacttt ggcgcacact tcaagagcaa ccgcgtgttt agctaaacaa
    11641 atcctctgcg aactcccagt taccaatggc tgctgccagt ggcgttttgc gtgcttttcc
    11701 gggttggact caagtgaaca gttaccggat aaggcgcagc agtcgggctg aacggggggt
    11761 tcttgcttac agcccagctt ggagcgaacg acctacaccg agccgagata ccagagtgtg
    11821 agctatgaga aagcgccaca cttcccgcaa gggagaaagg cggaacaggt atccgggaaa
    11881 cggcagggtt ggaacaggag agcgcaagag ggagcgattc atcggaaacg gtgatgatct
    11941 ttaagtcctg tcgggtttcg ccactcctga ctgattcatg gttgagccac cggctcccac
    12001 agatgcaccg aaaaagcgtc tgtttatgtg aactcagtca ggagggcgga gcctatggaa
    12061 aaacgccacc tgcgtggcct tgccgttttg cctcacatgt tagtcccctg cttattcacg
    12121 gaatctgtgg gtaactttgc atgtgtccgc agcgcccgcc gcagtctcac ggccggagcg
    12181 tagcgaccga gtgagcgagg aggcgcaatt tccccggcac ctacaagacg gacaccggac
    12241 gcgctgatgt ggcatattgt cccctgatta agtctttata ttccctgata ataaattacc
    12301 aggataggtg aatcatatcg gtttttcgct gaacatttta cgttaaccta tctctgttgc
    12361 ttttttctcc ttacggagaa atacaggtca tccccgcgag ggcgtggctg acctcagggg
    12421 gatatcccct gcttacgctg gctggacgcc accgacgcac ggtctctccc cctctttctg
    12481 gctccgtccg gctggacgcc ggccacgcca gaaattcacc cggcccccgt caggctcacg
    12541 cctgaccacc cacaaaaatc cacggtgctg gacgcacctg gcgaagcagc aaagctgctc
    12601 ctgattttgc gggtggtcag ccgctcgcta tggcgaactc tgacgggggc cggaacaccg
    12661 gaaaagaccg cactggggtg ccgccttttc ctctcacacg ctggggcgtg ctcgttgttc
    12721 ctccggggct gcgccttttc cgcatggggc ggaaagaggc tggcctccgt ggtgaaagct
    12781 gaacgcaatc accacggacg tgaccgccgc cgccatgcct tggggcatgt ccgcggcttg
    12841 tgcagcgggg gctgcacatc acgccggcaa accatcgtct gaaggagaga gaacatgttt
    12901 aatacggatt cgcttgcctg gaagtggcac attccggagc tggcccggca gatttatccg
    12961 tgggtcagct ggctgtacca ggagtattac ggtctggccg gggctttcct agttatcggc
    13021 ctgtttttcg gtctggctga actttgggcc ggacggatgc gttttgtggg gctgagtcat
    13081 aaggagcgac gggagtatgc cgatcgctat aagcgcgata ataaacggcc agcgccattt
    13141 tcggtgctgg cctcgctgga ttcgcccggg cggatggtca gggcacgtcg acatgtctgg
    13201 aactacgcgt actggctgac cggcgcggcc ggtctggccc ttctgggggg gctggttgtc
    13261 gccgtgttta tcgagagctg gggagaaacc gtcctgcgtc cggacctcta cgcaaacgca
    13321 gattattacc tgctgcagcc ggctaacctg ttcgggattg cctggtgcgc gggcgggctg
    13381 gctgtcggga ttgtgttggc gcggctgctg gcgttcctgc tgcttgacgg tcattttgcg
    13441 gctgctgacg aggcggtgaa cgcgaaactg aatcaggaga gccggcgcag cagccagcgg
    13501 acaggagaga tgaccgacgt gcgccacctg catttcgggg agccggtacc ggttaatgcg
    13561 ctggccgatt tttcctcgga gcaggcccgg caggagcagg cggtgtttct gggtaaggat
    13621 gagcagggca agccgg
//
