LOCUS       OW967426               13636 bp    DNA     circular BCT 22-MAY-2022
DEFINITION  Klebsiella pneumoniae isolate 512 genome assembly, plasmid: P3.
ACCESSION   OW967426
VERSION     OW967426.1
DBLINK      BioProject: PRJEB42440
            BioSample: SAMEA8065851
KEYWORDS    .
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1
  AUTHORS   Alioto,T., Alioto,T. and Gomez Garrido,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-MAY-2022) CNAG-CRG, CNAG, Spain
FEATURES             Location/Qualifiers
     source          1..13636
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
                     /isolate="512"
                     /isolation_source="Hospital Reina Sofia (Cordoba)"
                     /db_xref="taxon:573"
                     /plasmid="P3"
     gene            complement(816..1520)
                     /locus_tag="AI2809V1_5235"
     mRNA            complement(816..1520)
                     /locus_tag="AI2809V1_5235"
                     /note="AI2809v1_5235.mrna"
     CDS             complement(816..1520)
                     /locus_tag="AI2809V1_5235"
                     /note="long variant; AI2809v1_5235.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="CAH5442879.1"
                     /translation="MNPFKGRHFQRDIIRWAVRWYCKYGISYRELQEMLAERGVNVDHS
                     TIYRWVQRYAPEMEKRLRWYWRNPSDLCPWHMDETYVKVNGRWAYLYRAVDSRGRTVDF
                     YLSSRRNSKAAYRFLGKILNNVKKWQIPRFINTDKAPAYGRALALLKREGRCPSDVEHR
                     QIKYRNNVIECDHGKLKRIIGATLGFKSMKTAYATIKGIEVMRALRKGQASAFYYGDPL
                     GEMRLVSRVFEM"
                     /name="hypothetical protein"
     exon            complement(816..1520)
                     /locus_tag="AI2809V1_5235"
                     /note="AI2809v1_5235.mrna"
                     /number=1
     gene            complement(1532..>1789)
                     /locus_tag="AI2809V1_5236"
     mRNA            complement(1532..1789)
                     /locus_tag="AI2809V1_5236"
                     /note="AI2809v1_5236.mrna"
     CDS             complement(1532..>1789)
                     /locus_tag="AI2809V1_5236"
                     /note="short variant; AI2809v1_5236.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="Streptomycin 3''-adenylyltransferase"
                     /protein_id="CAH5443004.1"
                     /translation="VIAEVSTQLSEVVGVIERHLEPTLLAVHLYGSAVDGGLKPHSDID
                     LLVTVTVRLDETTRRALINDLLETALLQIVGGDKLIIPFC"
                     /name="Streptomycin 3''-adenylyltransferase"
     exon            complement(1532..1789)
                     /locus_tag="AI2809V1_5236"
                     /note="AI2809v1_5236.mrna"
                     /number=1
     gene            complement(1871..2476)
                     /locus_tag="AI2809V1_5237"
     mRNA            complement(1871..2476)
                     /locus_tag="AI2809V1_5237"
                     /note="AI2809v1_5237.mrna"
     CDS             complement(1871..2476)
                     /locus_tag="AI2809V1_5237"
                     /note="long variant; AI2809v1_5237.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="Aminoglycoside N(6')-acetyltransferase type 1"
                     /protein_id="CAH5443128.1"
                     /translation="MSIQHFQTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRS
                     HIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGW
                     WEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAI
                     RCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSVA"
                     /name="Aminoglycoside N(6')-acetyltransferase type 1"
     exon            complement(1871..2476)
                     /locus_tag="AI2809V1_5237"
                     /note="AI2809v1_5237.mrna"
                     /number=1
     gene            complement(2659..3216)
                     /locus_tag="AI2809V1_5238"
     mRNA            complement(2659..3216)
                     /locus_tag="AI2809V1_5238"
                     /note="AI2809v1_5238.mrna"
     CDS             complement(2659..3216)
                     /locus_tag="AI2809V1_5238"
                     /note="long variant; AI2809v1_5238.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="Transposon Tn3 resolvase"
                     /protein_id="CAH5443253.1"
                     /translation="MRIFGYARVSTSQQSLDIQIRALKDAGVKANRIFTDKASGSSTDR
                     EGLDLLRMKVEEGDVILVKKLDRLGRDTADMIQLIKEFDAQGVAVRFIDDGISTDGDMG
                     QMVVTILSAVAQAERRRILERTNEGRQEAKLKGIKFGRRRTVDRNVVLTLHQKGTGATE
                     IAHQLSIARSTVYKILEDERAS"
                     /name="Transposon Tn3 resolvase"
     exon            complement(2659..3216)
                     /locus_tag="AI2809V1_5238"
                     /note="AI2809v1_5238.mrna"
                     /number=1
     gene            3378..6383
                     /locus_tag="AI2809V1_5239"
     mRNA            3378..6383
                     /locus_tag="AI2809V1_5239"
                     /note="AI2809v1_5239.mrna"
     CDS             3378..6383
                     /locus_tag="AI2809V1_5239"
                     /note="long variant; AI2809v1_5239.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="CAH5443371.1"
                     /translation="MPVDFLTTEQVESYGRFTGEPDELQLARYFHLDEADKEFIGKSRG
                     DHNRLGIALQIGCVRFLGTFLTDMNHIPSGVRHFTARQLGIRDITVLAEYGQRENTRRE
                     HAALIRQHYQYREFAWPWTFRLTRLLYTRSWISNERPGLLFDLATGWLMQHRIILPGAT
                     TLTRLISEVREKATLRLWNKLALIPSAEQRSQLEMLLGPTDCSRLSLLESLKKGPVTIS
                     GPAFNEAIERWKTLNDFGLHAENLSTLPAVRLKNLARYAGMTSVFNIARMSPQKRMAVL
                     VAFVLAWETLALDDALDVLDAMLAVIIRDARKIGQKKRLRSLKDLDKSALALASACSYL
                     LKEETPDESIRAEVFSYIPRQKLAEIITLVREIARPSDDNFHDEMVEQYGRVRRFLPHL
                     LNTVKFSSAPAGVTTLNACDYLSREFSSRRQFFDDAPTEIISQSWKRLVINKEKHITRR
                     GYTLCFLSKLQDSLRRRDVYVTGSNRWGDPRARLLQGADWQANRIKVYRSLGHPTDPQE
                     AIKSLGHQLDSRYRQVAARLGENEAVELDVSGPKPRLTISPLASLDEPDSLKRLSKMIS
                     DLLPPVDLTELLLEINAHTGFADEFFHASEASARVDDLPVSISAVLMAEACNIGLEPLI
                     RSNVPALTRHRLNWTKANYLRAETITSANARLVDFQATLPLAQIWGGGEVASADGMRFV
                     TPVRTINAGPNRKYFGNNRGITWYNFVSDQYSGFHGIVIPGTLRDSIFVLEGLLEQETG
                     LNPTEIMTDTAGASDLVFGLFWLLGYQFSPRLADAGASVFWRMDHDADYGVLNDIARGQ
                     SDPRKIVLQWDEMIRTAGSLKLGKVQASVLVRSLLKSERPSGLTQAIIEVGRINKTLYL
                     LNYIDDEDYRRRILTQLNRGESRHAVARAICHGQKGEIRKRYTDGQEDQLGALGLVTNA
                     VVLWNTIYMQAALDHLRAQGETLNDEDIARLSPLCHGHINMLGHYSFTLAELVTKGHLR
                     PLKEASEAENVA"
                     /name="hypothetical protein"
     exon            3378..6383
                     /locus_tag="AI2809V1_5239"
                     /note="AI2809v1_5239.mrna"
                     /number=1
     gene            <6376..6708
                     /locus_tag="AI2809V1_5240"
     mRNA            6376..6708
                     /locus_tag="AI2809V1_5240"
                     /note="AI2809v1_5240.mrna"
     CDS             <6376..6708
                     /locus_tag="AI2809V1_5240"
                     /note="short variant; AI2809v1_5240.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="CAH5443495.1"
                     /translation="LLNVSFRSTERQTPFDPNFSTQKADTTRMMVPFFRQFWDMGAKDK
                     ATGKSRSDVQQRIQQFHSQEFLNSLQGTTQFAGTDYRSKDLTPKKSRLLADTISAVYLD
                     GYEGRQ"
                     /name="hypothetical protein"
     exon            6376..6708
                     /locus_tag="AI2809V1_5240"
                     /note="AI2809v1_5240.mrna"
                     /number=1
     gene            7014..7277
                     /locus_tag="AI2809V1_5241"
     mRNA            7014..7277
                     /locus_tag="AI2809V1_5241"
                     /note="AI2809v1_5241.mrna"
     CDS             7014..7277
                     /locus_tag="AI2809V1_5241"
                     /note="long variant; AI2809v1_5241.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="CAH5443623.1"
                     /translation="MSNTTHYENANFLRELAESLPRILPEGGPDKAALLQRLANEELAQ
                     AEYEDQVRAKVTAARADTRPGMTTEQLRQRLHGRYQELRDAV"
                     /name="hypothetical protein"
     exon            7014..7277
                     /locus_tag="AI2809V1_5241"
                     /note="AI2809v1_5241.mrna"
                     /number=1
     gene            7267..7566
                     /locus_tag="AI2809V1_5242"
     mRNA            7267..7566
                     /locus_tag="AI2809V1_5242"
                     /note="AI2809v1_5242.mrna"
     CDS             7267..7566
                     /locus_tag="AI2809V1_5242"
                     /note="long variant; AI2809v1_5242.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="CAH5443752.1"
                     /translation="MPYDVEWKQGAIEDVTTLFDYIAENSSLWDAQNVTDRVLAAADKL
                     ADFPRLYEVDSRYGEDVRRISLMGQHVLYDVDDQTRKVRVLAVVGQRQNPHIVL"
                     /name="hypothetical protein"
     exon            7267..7566
                     /locus_tag="AI2809V1_5242"
                     /note="AI2809v1_5242.mrna"
                     /number=1
     gene            complement(7628..8005)
                     /locus_tag="AI2809V1_5243"
     mRNA            complement(7628..8005)
                     /locus_tag="AI2809V1_5243"
                     /note="AI2809v1_5243.mrna"
     CDS             complement(7628..8005)
                     /locus_tag="AI2809V1_5243"
                     /note="long variant; AI2809v1_5243.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="CAH5443876.1"
                     /translation="MAWVTVRQATELTGKARSSLYRDMAKGRVSYRTEADGGRVVDTSE
                     LIRVYGELRQDETHERDELRLSGETEKMASDALIAEIKALREEVAGLRQEMQSMRLLEH
                     KPETAETPAGTPRRWWPWGKR"
                     /name="hypothetical protein"
     exon            complement(7628..8005)
                     /locus_tag="AI2809V1_5243"
                     /note="AI2809v1_5243.mrna"
                     /number=1
     gene            8074..8253
                     /locus_tag="AI2809V1_5244"
     mRNA            8074..8253
                     /locus_tag="AI2809V1_5244"
                     /note="AI2809v1_5244.mrna"
     CDS             8074..8253
                     /locus_tag="AI2809V1_5244"
                     /note="long variant; AI2809v1_5244.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="Regulatory protein rop"
                     /protein_id="CAH5443994.1"
                     /translation="MTKQEKTALNMAKFIKEQSLLLLDKLNELDMDTPADMCERLHEDA
                     ETLWQVMRDKLGEE"
                     /name="Regulatory protein rop"
     exon            8074..8253
                     /locus_tag="AI2809V1_5244"
                     /note="AI2809v1_5244.mrna"
                     /number=1
     gene            complement(8281..8811)
                     /locus_tag="AI2809V1_5245"
     mRNA            complement(8281..8811)
                     /locus_tag="AI2809V1_5245"
                     /note="AI2809v1_5245.mrna"
     CDS             complement(8281..8811)
                     /locus_tag="AI2809V1_5245"
                     /note="long variant; AI2809v1_5245.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="CAH5444114.1"
                     /translation="MALYMVFIEDAEDRNGERCIMPTSEHLEDMVVLAWQTGAYVFCFV
                     DRAQHLAMMKSIGMYDERLNSDEKATYFFTGKNPQWERNKPTGMKLCDYLYRKVERFAI
                     ENGVQVVDAGKCSPEQINAMIDVVSERHGESAVNEKLKAELMREYNSRYFNVPVPELPE
                     DKPARRWWPFGKK"
                     /name="hypothetical protein"
     exon            complement(8281..8811)
                     /locus_tag="AI2809V1_5245"
                     /note="AI2809v1_5245.mrna"
                     /number=1
     gene            complement(8818..9549)
                     /locus_tag="AI2809V1_5246"
     mRNA            complement(8818..9549)
                     /locus_tag="AI2809V1_5246"
                     /note="AI2809v1_5246.mrna"
     CDS             complement(8818..9549)
                     /locus_tag="AI2809V1_5246"
                     /note="long variant; AI2809v1_5246.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="CAH5444219.1"
                     /translation="MALELYNVSHAKRQARNAEKTRLTLRWLREELCSTAELVARRLGI
                     AAVQPVYRFLDSLVAKGLLVRTKYPVDGRQVSVWGLTPHGVAFSFDEDEPLADVIPFQP
                     SRVSAAHLPHRLAVQSLRLDMEARGATGWRILHRLSLKGMKVPDALAELDGKTVAFEVE
                     RTVKSRRRYQEVVSGYLFNRKANGIDEIWYICPDRATQVRVQRAILSVDEIVNPQTGEA
                     RKTAELDRERLFACFKFMTTE"
                     /name="hypothetical protein"
     exon            complement(8818..9549)
                     /locus_tag="AI2809V1_5246"
                     /note="AI2809v1_5246.mrna"
                     /number=1
     gene            complement(9549..11513)
                     /locus_tag="AI2809V1_5247"
     mRNA            complement(9549..11513)
                     /locus_tag="AI2809V1_5247"
                     /note="AI2809v1_5247.mrna"
     CDS             complement(9549..11513)
                     /locus_tag="AI2809V1_5247"
                     /note="long variant; AI2809v1_5247.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="CAH5444349.1"
                     /translation="MFNTDSLAWKWHIPELARQIYPWVSWLYQEYYGLAGAFLVIGLFF
                     GLAELWAGRMRFVGLSHKERREYADRYKRDNKRPAPFSVLASLDSPGRMVRARRHVWNY
                     AYWLTGAAGLALLGGLVVAVFIESWGETVLRPDLYANADYYLLQPANLFGIAWCAGGLA
                     VGIVLARLLAFLLLDGHFAAADEAVNAKLNQESRRSSQRTGEMTDVRHLHFGEPVPVNA
                     LADFSSEQARQEQAVFLGKDEQGKPVLVPRDTWRKTNIQILGLPGSGKSVMATNALIRC
                     VRDFGDAVVYFDPKGDAWAPHVFRAHCPDFTLLDLRPGKPAQLNLFRDLDQYALKNLLI
                     AGLNLGETGDVADHYRISEQKAAKLIAEQFPQGANIQQVLAAAYALPEALKKDVKGLIT
                     RLENVADLSVLQTDSGIDVAGIINGGGCLYVIGSMDDEAVIRVQKMLFARCAQIIIARD
                     EFREWPHVSVMLDEIKYLLSKYVLNALGTLRSRDCNLLLAHQSLGDFGQCGQDLPAEFV
                     KTTVLDNTPIRWFYRAASLESAQWAAGQTGEIRVDVERRRASREAGNVEHISGDSFIQK
                     EARPLFDVNTLQHLPDGFAVMTGLGVARMAFSSPLRVERREIPLQRFPVLAKTDPLAEF
                     RPPADGGGPKADDDFAGIY"
                     /name="hypothetical protein"
     exon            complement(9549..11513)
                     /locus_tag="AI2809V1_5247"
                     /note="AI2809v1_5247.mrna"
                     /number=1
     gene            complement(12225..12353)
                     /locus_tag="AI2809V1_5248"
     mRNA            complement(12225..12353)
                     /locus_tag="AI2809V1_5248"
                     /note="AI2809v1_5248.mrna"
     CDS             complement(12225..12353)
                     /locus_tag="AI2809V1_5248"
                     /note="long variant; AI2809v1_5248.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="CAH5444471.1"
                     /translation="MEKRHLRGLAVLPHMLVPCLFTESVGNFACVRSARRSLTAGA"
                     /name="hypothetical protein"
     exon            complement(12225..12353)
                     /locus_tag="AI2809V1_5248"
                     /note="AI2809v1_5248.mrna"
                     /number=1
     gene            complement(13228..13485)
                     /locus_tag="AI2809V1_5249"
     mRNA            complement(13228..13485)
                     /locus_tag="AI2809V1_5249"
                     /note="AI2809v1_5249.mrna"
     CDS             complement(13228..13485)
                     /locus_tag="AI2809V1_5249"
                     /note="long variant; AI2809v1_5249.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="Colicin-E3 immunity protein"
                     /protein_id="CAH5444596.1"
                     /translation="MGLKLHIHWFDKKTEEFKGGEYSKDFGDDGSVIESLGMPLKDNIN
                     NGWFDVEKSWVSILQPHFKNVIDISKFDYFVSFVYRDGNW"
                     /name="Colicin-E3 immunity protein"
     exon            complement(13228..13485)
                     /locus_tag="AI2809V1_5249"
                     /note="AI2809v1_5249.mrna"
                     /number=1
     ARG             complement(1875..2425)
                     /name="aac(6')-Ib"
                     /gene="aac(6')-Ib"
                     /gene_name="AAC(6')-Ib family aminoglycoside
                     6'-N-acetyltransferase"
                     /tool="amrfinderplus"
                     /drug_class="AMINOGLYCOSIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             complement(1533..1789)
                     /name="aadA15"
                     /gene="aadA15"
                     /gene_name="ANT(3'')"
                     /tool="rgi"
                     /drug_class="aminoglycoside antibiotic"
                     /identity="97.14"
                     /coverage="32.32"
     ARG             complement(1872..2476)
                     /name="AAC(6')-Ib10"
                     /gene="AAC(6')-Ib10"
                     /gene_name="AAC(6')"
                     /tool="rgi"
                     /drug_class="aminoglycoside antibiotic"
                     /identity="98.97"
                     /coverage="99.01"
     Typing          12313..12891
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="95.361"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(8822..9549)
                     /name="MOBC"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="1.34e-150"
ORIGIN
        1 ttacgctttt tatcaccata ccatcgggcc cgcttaccac caccaccttg tttaggggtt
       61 ttaggtttac cctctttcaa ctctcccaac cccttaatat cttcagtctt gggatcagga
      121 aaataatcat ggccgtaatc tttagttccc ttacgaggtt ttttcttttc ctcatttaat
      181 ttattttctg catccttcgc ttttttctcc ttttgtttcc ggctctccat cgccccggaa
      241 agcgcagcct tatccctgga taaggattca ttcatttcgt ttaaagatgt ctgggcagct
      301 tttaatttct cattctgatt ctgaatatcc ttatcaagat agcgaacctg atcctgccac
      361 ccggagccat attcatgagg cgggttataa gtcacaaaat catctttatt tgcctctgcc
      421 tcttttacct ttttatcggc ttcggggtct gacgctcagt ggaacgaaaa ctcacgttaa
      481 gggattttgg tcatgagatt atcaaaaagg atcttcacct agatcctttt aaattaaaaa
      541 tgaagtttta aatcaatcta aagtatatat gagtaaactt ggtctgacag ttaccaatgc
      601 ttaatcagtg aggcacctat ctcagcgatc tgtctatttc gttcatccat agttgcctga
      661 ctccccgtcg tgtagataac tacgatacgg gagggcttac catctggccc cagtgctgca
      721 atgataccgc gagacccacg ctcaccggct ccagatttat cagggcactg ttgcaaagtt
      781 agcgatgagg cagccttttg tcttattcaa aggccttaca tttcaaaaac tctgcttacc
      841 aggcgcattt cgcccagggg atcaccataa taaaatgctg aggcctggcc tttgcgtagt
      901 gcacgcatca cctcaatacc tttgatggtg gcgtaagccg tcttcatgga tttaaatccc
      961 agcgtggcgc cgattatccg tttcagtttg ccatgatcgc attcaatcac gttgttccgg
     1021 tacttaatct gtcggtgttc aacgtcagac gggcaccggc cttcgcgttt gagcagagca
     1081 agcgcgcgac cataggcggg cgctttatcc gtgttgatga atcgcgggat ctgccacttc
     1141 ttcacgttgt tgaggatttt acccagaaac cggtatgcag ctttgctgtt acgacgggag
     1201 gagagataaa aatcgacagt gcggccccgg ctgtcgacgg cccggtacag atacgcccag
     1261 cggccattga ccttcacgta ggtttcatcc atgtgccacg ggcaaagatc ggaagggtta
     1321 cgccagtacc agcgcagccg tttttccatt tcaggcgcat aacgctgaac ccagcggtaa
     1381 atcgtggagt gatcgacatt cactccgcgt tcagccagca tctcctgcag ctcacggtaa
     1441 ctgatgccgt atttgcagta ccagcgtacg gcccaccgaa tgatgtcacg ctgaaaatgc
     1501 cggcctttga atgggttcat gtgcagctcc atcagcaaaa ggggatgata agtttatcac
     1561 caccgactat ttgcaacagt gccgtttcca aaaggtcgtt gatcaaagct cgccgcgttg
     1621 tttcatcaag ccttacggtc accgtaacca gcaaatcaat atcactgtgt ggcttcaggc
     1681 cgccatccac tgcggagccg tacaaatgta cggccagcaa cgtcggttcg agatggcgct
     1741 cgatgacgcc aactacctct gatagttgag tcgatacttc ggcgatcacc gcttccctca
     1801 tgatgtttaa cgtttgacat gaggggcggc caagggcgcc agcccttgga cgtccccctc
     1861 gatggaaggg ttaggcaaca ctgcgtgttc gctcgaatgc ctggcgtgtt tgaaccatgt
     1921 acacggctgg accatctggg gtggttacgg taccttgcct ctcaaacccc gctttctcgt
     1981 agcatcggat cgctcgcaag ttgctcggcg acgggtccgt ttggatcttg gtgacctcgg
     2041 gatcattgaa cagcaactca accagagctc gaaccagctt ggttcccaag cctttgccca
     2101 gttgtgatgc attcgccagt aactggtcta ttccgcgtac tcctggatcg gtttcttctt
     2161 cccaccatcc gtccccgctt ccaagagcaa cgtacgactg ggcataccca atcggctctc
     2221 cattcagcat tgcaatgtat ggagtgacgg actcttgcgc taaaacgctt ggcaagtact
     2281 gttcctgtac gtcagcaagt gtcgggcgtg cttcttctcc gccccaccac tcgacgatat
     2341 gagatcgatt tagccactca tagagcatcg caaggtcatg ctcagtcatg aggcgcagtg
     2401 tgacggaatc gttgctgttg gtcacgatgc tgtactttgt gatgcctaac tttgtttgga
     2461 aatgttgaat actcatactc ttcctttttc aatattattg aagcatttat cagggttatt
     2521 gtctcatgag cggatacata tttgaatgta tttagaaaaa taaacaaata ggggttccgc
     2581 gcacttttcc ccgaaaagtg ccacctgacg tctaagaaac cattattatc atgacattaa
     2641 cctataaaaa taggcgtatc acgaggccct ttcgtcttca agaattttat aaaccgtgga
     2701 gcgggcaata ctgagctgat gagcaatttc cgttgcacca gtgcccttct gatgaagcgt
     2761 cagcacgacg ttcctgtcca cggtacgcct gcggccaaat ttgattcctt tcagctttgc
     2821 ttcctgtcgg ccctcattcg tgcgctctag gatcctccgg cgttcagcct gtgccacagc
     2881 cgacaggatg gtgaccacca tttgccccat atcaccgtcg gtactgatcc cgtcgtcaat
     2941 aaaccgaacc gctacaccct gagcatcaaa ctcttttatc agttggatca tgtcggcggt
     3001 gtcgcggcca agacggtcga gcttcttcac cagaatgaca tcaccttcct ccaccttcat
     3061 cctcagcaaa tccagccctt cccgatctgt tgaactgccg gatgccttgt cggtaaagat
     3121 gcggttagct tttacccctg catctttgag cgctctgatc tgaatatcga gggactgctg
     3181 gctggttgag acccgcgcat aaccaaaaat tcgcataaaa atgtacctta aatcgaatat
     3241 cagacacgat gtgtctatta tgccaaaatg acgatttaat ggacactcaa acgaagccgt
     3301 tttactatgt ctgataattt ataatatttc gaacggttgc agttgtgtta aaaaagccgt
     3361 caggcaggga ggccgatatg cccgttgatt ttttgaccac tgagcaggtt gagagttatg
     3421 gcaggttcac tggcgaaccc gatgaacttc agctggcgcg ttattttcat cttgatgaag
     3481 cggataaaga atttatcggg aaaagccggg gtgatcacaa tcgacttggt attgccctgc
     3541 aaatcgggtg tgtgcgtttt ctgggcactt ttcttactga catgaatcat attccttccg
     3601 gcgtccggca ttttaccgcc agacagctcg ggattcgtga tatcaccgtt cttgcagaat
     3661 acggtcagag ggaaaatacc cgccgtgagc atgcagcgct gatacgtcag cactatcagt
     3721 atcgtgaatt tgcctggccc tggacatttc gccttacccg tcttttatat acccggagct
     3781 ggataagcaa cgaacgtcct ggcctgcttt tcgacctggc gacagggtgg cttatgcaac
     3841 atcgtattat tctccccgga gccaccacgc tgacccggtt gatttcagag gtaagggaaa
     3901 aggcgacgtt gcgcctgtgg aacaaactgg cactgatacc gtcagccgaa cagcgttcac
     3961 agctggagat gctgctgggg ccaactgatt gcagccgcct gtctttactg gaatcactga
     4021 aaaaaggccc tgtgaccatc agtggtccgg cgtttaatga agcaattgaa cgctggaaaa
     4081 ctctgaacga ttttggcctg catgctgaaa acctgagtac actcccggct gtgcgcctga
     4141 aaaatctcgc acgttatgct ggtatgactt cggtgttcaa tattgccagg atgtcaccgc
     4201 agaaaaggat ggcggttctg gttgcctttg tccttgcatg ggaaacgctg gcgctggatg
     4261 atgcactgga cgttctggac gccatgctgg ccgttatcat ccgtgacgcc agaaagattg
     4321 ggcagaaaaa acggctccgc tcgctgaagg atctggataa atctgcattg gcgctcgcca
     4381 gcgcatgttc gtacttgctg aaagaagaaa caccggacga atcgattcgt gctgaggtgt
     4441 tcagctacat ccctaggcaa aagctggctg aaatcatcac gcttgtccgt gaaattgccc
     4501 ggccctcaga cgataatttt catgacgaaa tggtggagca gtacgggcgc gttcgtcgtt
     4561 tcctgcccca tctgctgaat accgttaaat tttcatccgc acctgccggg gttaccactc
     4621 tgaatgcctg tgactacctc agccgggagt tcagctcacg gcggcagttt tttgacgacg
     4681 caccaacgga aatcatcagt cagtcatgga aacggctggt gattaacaag gaaaaacata
     4741 tcacccgaag gggatacacg ctctgctttc tcagtaaact gcaggatagt ctgagacgga
     4801 gggatgtcta cgttaccggc agtaaccggt ggggagatcc tcgtgcaaga ttactacagg
     4861 gtgctgactg gcaggcaaat cggattaagg tttatcgttc tttggggcac ccgacagacc
     4921 cgcaggaagc aataaaatct ctgggccatc agcttgatag tcgttacaga caggttgctg
     4981 cacgtcttgg cgaaaatgag gctgtcgaac tcgatgtttc tggcccgaag ccccggttga
     5041 caatttctcc cctcgccagt cttgatgagc cggacagtct gaaacgactg agcaaaatga
     5101 tcagtgatct gctccctccg gtggatttaa cggagttgct gctcgaaatt aacgcccata
     5161 ccggatttgc tgatgagttt ttccatgcca gtgaagccag tgccagagtt gatgatctgc
     5221 ccgtcagcat cagcgccgtg ctgatggctg aagcctgcaa tatcggtctg gaaccactga
     5281 tcagatcaaa tgttcctgca ctgacccgac accggctgaa ctggacaaaa gcgaactatc
     5341 tgcgggctga aactatcacc agcgctaatg ccagactggt tgattttcag gcaacgctgc
     5401 cactggcaca gatatggggt ggaggagaag tggcatctgc agatggaatg cgctttgtta
     5461 cgccagtcag aacaatcaat gccggaccga accgcaaata ctttggtaat aacagaggga
     5521 tcacctggta caactttgtg tccgatcagt attccggctt tcatggcatc gttataccgg
     5581 ggacgctgag ggactctatc tttgtgctgg aaggccttct ggaacaggag accgggctga
     5641 atccaaccga aattatgacc gatacggcag gtgccagcga tcttgtcttt ggccttttct
     5701 ggctgctggg ataccagttt tctccacgcc tggctgatgc cggtgcttcg gttttctggc
     5761 gaatggacca tgatgccgac tatggcgtgc tgaatgatat tgccagaggg caatcagatc
     5821 cccgaaaaat agtccttcag tgggacgaaa tgatccggac cgcaggctcc ctgaagctgg
     5881 gcaaagtaca ggcctcagtg ctggtccgtt cattgctgaa aagtgaacgt ccctccggac
     5941 tgactcaggc aatcattgaa gtggggcgca tcaacaaaac gctgtatctg cttaattata
     6001 ttgatgatga agattaccgc cggcgcattc tgacccagct taatcgggga gaaagccgtc
     6061 atgcagttgc cagagccatc tgtcacggtc aaaaaggtga gataagaaaa cgatataccg
     6121 acggtcagga agatcagttg ggagctctgg ggctggtcac taacgccgtc gtgttatgga
     6181 acactattta tatgcaggca gctctggatc atctccgggc gcagggtgaa acactgaatg
     6241 atgaagatat cgcacgcctc tccccgcttt gccacggaca tatcaatatg ctcggccatt
     6301 attccttcac gctggcagaa ctggtgacca aaggtcatct gagaccatta aaagaggcgt
     6361 cagaggcaga aaacgttgct taacgtgagt tttcgttcca ctgagcgtca gacccctttt
     6421 gatcccaatt tttccaccca gaaagctgac acaacacgaa tgatggtgcc ttttttccgg
     6481 cagttctggg atatgggcgc aaaggataaa gcgaccggaa aatcacggag tgatgtgcag
     6541 caacgcattc agcagtttca cagtcaggaa tttttaaact cactccaagg cacaacacaa
     6601 tttgcgggta ccgattaccg cagcaaagac ctcacaccga aaaaatcaag gctactggct
     6661 gacaccattt cagctgttta tctcgatggc tatgaaggca gacagtaagt ggatttacca
     6721 taacgcgtca ttacgcgcac cgctcagacg ggctcagggc gtttccggcg gctacgggat
     6781 aaaacaggca acaacccccc cggaaaactg ccggaaacgc gcccgataaa ttttatccta
     6841 atgcatgcct atgcacgcaa ctgcatggca tatgttttga cgtaaaatgg atgccgtaag
     6901 ccctttttta ccgactttct gcttcatcag cctgactgac acgaccatat tctttcagac
     6961 cgccccctgc taaacttcct tcatattgcc gcattaaccc gggaggctcc gcaatgagca
     7021 acactacaca ctacgaaaac gccaactttc ttcgggaact ggctgaaagc ctgccccgca
     7081 tactgccgga aggtggcccg gacaaagctg cgctgttgca gcgactggct aacgaagaac
     7141 tggcccaggc agagtatgaa gatcaggttc gcgccaaagt gaccgccgcc cgtgctgaca
     7201 cgcgtccggg tatgaccacg gaacaactcc gccagcgcct gcatggccgt tatcaggaac
     7261 tgcgcgatgc cgtatgacgt ggaatggaag cagggagcca tcgaggatgt aacgacgctg
     7321 tttgactata tcgcggaaaa ttcatccctg tgggatgcgc agaacgttac cgaccgggtt
     7381 ctcgctgcgg cggacaaact ggccgacttc ccgcgactct atgaagtgga ctcacgctat
     7441 ggcgaggacg ttcgccggat cagtctgatg ggacagcatg tcctctatga tgttgatgac
     7501 cagaccagaa aagtccgggt tctggccgtg gtcggccagc gccagaatcc ccatattgtt
     7561 ctctaataac cggtgacggg gacgcaattc attgcgtggc cgtcgccggt tggacaagca
     7621 cagcgcgtca gcgttttccc cacggccacc accggcgcgg tgttccggcc ggggtctctg
     7681 ctgtctccgg tttgtgttcc agcagtctca tggactgcat ttcctgccgt agcccggcca
     7741 cctcctccct gagtgctttt atctccgcga tcaacgcgtc ggaggccatt ttttcagtct
     7801 cacccgacag tctcaactcg tcccgctcgt gagtctcatc ctgtcttaac tcaccgtaca
     7861 cccggataag ctcgctggta tccaccaccc ggccgccatc agcttccgta cggtatgata
     7921 cgcggccttt cgccatatcc cgatacaggg aacttcgggc tttacccgtc agttccgtcg
     7981 cctgtctcac cgtcacccac gccattgtct caccccgcta tttttgagac agtatacctg
     8041 acaggcgcac accatgcccg gaaggaaaga atcatgacaa aacaggaaaa aacagccctc
     8101 aatatggcta aatttattaa ggagcagtcg ctgctattgc tcgataaact gaatgagctg
     8161 gatatggata ccccggccga catgtgcgag cggctacacg aggatgcgga aacactctgg
     8221 caggtgatgc gggataagct cggggaggaa taacagcacc ggcatggccg gtgctggcat
     8281 ttattttttg ccgaacggcc accaccggcg ggcaggtttg tcctccggca gttcaggtac
     8341 cggcacgtta aaatagcggc tgttatattc ccgcatcagc tccgctttca gcttctcgtt
     8401 caccgcgctt tccccgtgcc gctcactcac cacgtcaatc atcgcgttaa tctgctccgg
     8461 tgagcacttc ccggcatcaa ccacctgcac accgttctcg atggcgaacc gctccacctt
     8521 gcgatagagg taatcacaca gcttcattcc tgtgggtttg ttccgttccc attgcggatt
     8581 tttaccagtg aaaaagtacg tggctttttc gtcgctgttg agccgctcgt catacatccc
     8641 gatggatttc atcatcgcca gatgctgggc ccggtcgaca aaacagaaaa catacgcccc
     8701 ggtctgccag gcgagcacca ccatatcttc cagatgctcg ctggtcggca tgatgcagcg
     8761 ctcgccgttc cggtcctccg cgtcttcaat aaataccatg tacagcgcca taatccctca
     8821 ctccgttgtc ataaatttaa agcacgcaaa caaccgttca cgatccagct ctgccgtttt
     8881 gcgggcctcg ccggtctgtg ggttcacgat ttcatccacc gacaggattg cccgctgcac
     8941 cctgacctgc gtcgcccggt ccgggcagat gtaccagatt tcatcgatgc cgttagcttt
     9001 gcggttgaac agatacccgg acaccacttc ctgataccgg cgacggctct tgacggtgcg
     9061 ctccacctca aacgccaccg ttttaccgtc cagctccgcc agggcgtccg gcactttcat
     9121 gcctttaaga ctcagacggt gcagaatgcg ccagccggtg gcccctctgg cttccatatc
     9181 aaggcgcagg gattgcacgg ccagccggtg cggcagatgt gctgccgaca cccttgacgg
     9241 ctgaaacgga ataacatccg ccagcggttc gtcctcgtcg aacgagaacg ccacgccatg
     9301 cggcgtcagc ccccacacgc tgacctgacg gccgtccacc ggatatttgg tccggaccag
     9361 cagccctttc gccaccaggc tgtcgaggaa gcggtagacc ggctgcaccg ccgcaatccc
     9421 cagccgccgc gcaaccagct ccgccgtgga acacagctct tcccgcaacc agcgcagggt
     9481 cagccgggtt ttctccgcgt tccgcgcctg tcgtttcgcg tggctgacgt tgtacagctc
     9541 cagcgccatc agtaaatccc cgcaaaatca tcatccgctt tcggcccgcc gccgtcggcc
     9601 gggggccgga actccgccag gggatcggtt ttcgccagca ccgggaaacg ctgcaacggg
     9661 atttcccggc gctcaacccg cagcggactg ctgaacgcca tccgggccac acccagcccg
     9721 gtcatgaccg cgaacccgtc cggcaggtgt tgcagggtgt tcacgtcaaa cagcggccgc
     9781 gcctccttct ggatgaagct gtccccgctg atatgctcca cgttccccgc ctcccggctg
     9841 gcacggcggc gctccacgtc caccctgatt tccccggtct gccccgccgc ccactgcgcg
     9901 gactccaggc tggccgcccg gtaaaaccag cggatcggcg tgttatccag taccgtggtt
     9961 ttcacaaatt cagcgggcag atcctgcccg cactgcccga aatcgcccag cgactggtgc
    10021 gcgagcaaca gattgcagtc ccggctgcgc agcgtcccca gtgcgttcag tacatacttc
    10081 gacagcagat atttaatttc atcgagcatc acgctgacgt gtggccactc ccggaactcg
    10141 tcccgcgcaa tgatgatttg cgcgcagcgg gcaaacagca ttttttgcac acggatcacc
    10201 gcctcgtcgt ccatcgagcc gataacgtac aggcagccgc cgccgttgat aatccccgcc
    10261 acatcgatgc cactgtccgt ctgcaggacg ctcaggtcag cgacgttttc cagcctagtg
    10321 atcaacccct tcacgtcctt tttcagggcc tccggcagcg cgtacgccgc cgccagcacc
    10381 tgctgaatgt ttgccccctg cggaaactgc tccgcaatca gcttcgccgc tttctgctcg
    10441 ctgatgcggt agtggtccgc cacgtcgccg gtctcgccca ggttaagccc ggcaatcagc
    10501 aggtttttca gcgcgtactg gtcgagatcg cggaacagat tcagctgcgc cggtttcccc
    10561 ggccgcagat ccagcagggt gaagtccgga cagtgcgccc ggaagacgtg cggcgcccat
    10621 gcgtcccctt tggggtcgaa gtacaccacc gcgtccccga aatcgcgtac gcagcgaatg
    10681 agcgcgttgg tggccatcac gctcttgccg ctcccgggca ggccgaggat ctgaatgttg
    10741 gtcttgcgcc aggtatcacg cggaaccagc accggcttgc cctgctcatc cttacccaga
    10801 aacaccgcct gctcctgccg ggcctgctcc gaggaaaaat cggccagcgc attaaccggt
    10861 accggctccc cgaaatgcag gtggcgcacg tcggtcatct ctcctgtccg ctggctgctg
    10921 cgccggctct cctgattcag tttcgcgttc accgcctcgt cagcagccgc aaaatgaccg
    10981 tcaagcagca ggaacgccag cagccgcgcc aacacaatcc cgacagccag cccgcccgcg
    11041 caccaggcaa tcccgaacag gttagccggc tgcagcaggt aataatctgc gtttgcgtag
    11101 aggtccggac gcaggacggt ttctccccag ctctcgataa acacggcgac aaccagcccc
    11161 cccagaaggg ccagaccggc cgcgccggtc agccagtacg cgtagttcca gacatgtcga
    11221 cgtgccctga ccatccgccc gggcgaatcc agcgaggcca gcaccgaaaa tggcgctggc
    11281 cgtttattat cgcgcttata gcgatcggca tactcccgtc gctccttatg actcagcccc
    11341 acaaaacgca tccgtccggc ccaaagttca gccagaccga aaaacaggcc gataactagg
    11401 aaagccccgg ccagaccgta atactcctgg tacagccagc tgacccacgg ataaatctgc
    11461 cgggccagct ccggaatgtg ccacttccag gcaagcgaat ccgtattaaa catgttctct
    11521 ctccttcaga cgatggtttg ccggcgtgat gtgcagcccc cgctgcacaa gccgcggaca
    11581 tgccccaagg catggcggcg gcggtcacgt ccgtggtgat tgcgttcagc tttcaccacg
    11641 gaggccagcc tctttccgcc ccatgcggaa aaggcgcagc cccggaggaa caacgagcac
    11701 gccccagcgt gtgagaggaa aaggcggcac cccagtgcgg tcttttccgg tgttccggcc
    11761 cccgtcagag ttcgccatag cgagcggctg accacccgca aaatcaggag cagctttgct
    11821 gcttcgccag gtgcgtccag caccgtggat ttttgtgggt ggtcaggcgt gagcctgacg
    11881 ggggccgggt gaatttctgg cgtggccggc gtccagccgg acggagccag aaagaggggg
    11941 agagaccgtg cgtcggtggc gtccagccag cgtaagcagg ggatatcccc ctgaggtcag
    12001 ccacgccctc gcggggatga cctgtatttc tccgtaagga gaaaaaagca acagagatag
    12061 gttaacgtaa aatgttcagc gaaaaaccga tatgattcac ctatcctggt aatttattat
    12121 cagggaatat aaagacttaa tcaggggaca atatgccaca tcagcgcgtc cggtgtccgt
    12181 cttgtaggtg ccggggaaat tgcgcctcct cgctcactcg gtcgctacgc tccggccgtg
    12241 agactgcggc gggcgctgcg gacacatgca aagttaccca cagattccgt gaataagcag
    12301 gggactaaca tgtgaggcaa aacggcaagg ccacgcaggt ggcgtttttc cataggctcc
    12361 gccctcctga ctgagttcac ataaacagac gctttttcgg tgcatctgtg ggagccggtg
    12421 gctcaaccat gaatcagtca ggagtggcga aacccgacag gacttaaaga tcatcaccgt
    12481 ttccgatgaa tcgctccctc ttgcgctctc ctgttccaac cctgccgttt cccggatacc
    12541 tgttccgcct ttctcccttg cgggaagtgt ggcgctttct catagctcac actctggtat
    12601 ctcggctcgg tgtaggtcgt tcgctccaag ctgggctgta agcaagaacc ccccgttcag
    12661 cccgactgct gcgccttatc cggtaactgt tcacttgagt ccaacccgga aaagcacgca
    12721 aaacgccact ggcagcagcc attggtaact gggagttcgc agaggatttg tttagctaaa
    12781 cacgcggttg ctcttgaagt gtgcgccaaa gtccggctac actggaagga cagatttggt
    12841 tgctgtgctc tgcgaaagcc agttaccacg gttaagcagt tccccaactg acttaacctt
    12901 cgatcaaacc acctccccag gtggtttttt cgtttacagg gcaaaagatt acgcgcagaa
    12961 aaaaaggatc tcaagaagat cctttgatct tttctactga accgcgatcc ccgtcagttc
    13021 agaggaggac gatggtgcca ccgttccacc ctgaacatcc cggatatagt ttgcctgaca
    13081 tgcgaccaga agaaagcctg aaaaaatcaa tataaaaaga aaaacaacct ttaccttttt
    13141 catatacctt ccctgtattt aaaaaccccg gtattcatcc ctgaacaccg gaagtctgta
    13201 tttcaaatca tccttgataa cttttgctta ccagttacca tcccggtaaa caaaggatac
    13261 aaagtaatca aatttactaa tatcgattac atttttaaag tgtggctgta atatcgaaac
    13321 ccatgatttt tcaacatcaa accaaccatt attaatatta tcctttaaag gcatccccag
    13381 actttcaatg acagaaccat catcaccgaa gtcttttgag tattcaccac ctttaaactc
    13441 ttcggttttc ttatcaaacc aatgaatatg taatttaagc cccatattta cctcttaaag
    13501 atatttttta atgtttcgtt ttggatccgg ccctttaacc tgcttacccg tttttggatc
    13561 gaatgccccg aggtgttcgc catcactggc gcggtaccct tcaagctcac cgtgctggga
    13621 atcccattca taaatt
//
