LOCUS       OW967254               13636 bp    DNA     circular BCT 22-MAY-2022
DEFINITION  Klebsiella pneumoniae isolate 512 genome assembly, plasmid: P4.
ACCESSION   OW967254
VERSION     OW967254.1
DBLINK      BioProject: PRJEB42440
            BioSample: SAMEA8065847
KEYWORDS    .
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1
  AUTHORS   Alioto,T., Alioto,T. and Gomez Garrido,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-MAY-2022) CNAG-CRG, CNAG, Spain
FEATURES             Location/Qualifiers
     source          1..13636
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
                     /isolate="512"
                     /isolation_source="Hospital Reina Sofia (Cordoba)"
                     /db_xref="taxon:573"
                     /plasmid="P4"
     gene            complement(70..>402)
                     /locus_tag="AI2805V1_5447"
     mRNA            complement(70..402)
                     /locus_tag="AI2805V1_5447"
                     /note="AI2805v1_5447.mrna"
     CDS             complement(70..>402)
                     /locus_tag="AI2805V1_5447"
                     /note="short variant; AI2805v1_5447.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="CAH5322834.1"
                     /translation="LLNVSFRSTERQTPFDPNFSTQKADTTRMMVPFFRQFWDMGAKDK
                     ATGKSRSDVQQRIQQFHSQEFLNSLQGTTQFAGTDYRSKDLTPKKSRLLADTISAVYLD
                     GYEGRQ"
                     /name="hypothetical protein"
     exon            complement(70..402)
                     /locus_tag="AI2805V1_5447"
                     /note="AI2805v1_5447.mrna"
                     /number=1
     gene            complement(395..3400)
                     /locus_tag="AI2805V1_5448"
     mRNA            complement(395..3400)
                     /locus_tag="AI2805V1_5448"
                     /note="AI2805v1_5448.mrna"
     CDS             complement(395..3400)
                     /locus_tag="AI2805V1_5448"
                     /note="long variant; AI2805v1_5448.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="CAH5322949.1"
                     /translation="MPVDFLTTEQVESYGRFTGEPDELQLARYFHLDEADKEFIGKSRG
                     DHNRLGIALQIGCVRFLGTFLTDMNHIPSGVRHFTARQLGIRDITVLAEYGQRENTRRE
                     HAALIRQHYQYREFAWPWTFRLTRLLYTRSWISNERPGLLFDLATGWLMQHRIILPGAT
                     TLTRLISEVREKATLRLWNKLALIPSAEQRSQLEMLLGPTDCSRLSLLESLKKGPVTIS
                     GPAFNEAIERWKTLNDFGLHAENLSTLPAVRLKNLARYAGMTSVFNIARMSPQKRMAVL
                     VAFVLAWETLALDDALDVLDAMLAVIIRDARKIGQKKRLRSLKDLDKSALALASACSYL
                     LKEETPDESIRAEVFSYIPRQKLAEIITLVREIARPSDDNFHDEMVEQYGRVRRFLPHL
                     LNTVKFSSAPAGVTTLNACDYLSREFSSRRQFFDDAPTEIISQSWKRLVINKEKHITRR
                     GYTLCFLSKLQDSLRRRDVYVTGSNRWGDPRARLLQGADWQANRIKVYRSLGHPTDPQE
                     AIKSLGHQLDSRYRQVAARLGENEAVELDVSGPKPRLTISPLASLDEPDSLKRLSKMIS
                     DLLPPVDLTELLLEINAHTGFADEFFHASEASARVDDLPVSISAVLMAEACNIGLEPLI
                     RSNVPALTRHRLNWTKANYLRAETITSANARLVDFQATLPLAQIWGGGEVASADGMRFV
                     TPVRTINAGPNRKYFGNNRGITWYNFVSDQYSGFHGIVIPGTLRDSIFVLEGLLEQETG
                     LNPTEIMTDTAGASDLVFGLFWLLGYQFSPRLADAGASVFWRMDHDADYGVLNDIARGQ
                     SDPRKIVLQWDEMIRTAGSLKLGKVQASVLVRSLLKSERPSGLTQAIIEVGRINKTLYL
                     LNYIDDEDYRRRILTQLNRGESRHAVARAICHGQKGEIRKRYTDGQEDQLGALGLVTNA
                     VVLWNTIYMQAALDHLRAQGETLNDEDIARLSPLCHGHINMLGHYSFTLAELVTKGHLR
                     PLKEASEAENVA"
                     /name="hypothetical protein"
     exon            complement(395..3400)
                     /locus_tag="AI2805V1_5448"
                     /note="AI2805v1_5448.mrna"
                     /number=1
     gene            3562..4119
                     /locus_tag="AI2805V1_5449"
     mRNA            3562..4119
                     /locus_tag="AI2805V1_5449"
                     /note="AI2805v1_5449.mrna"
     CDS             3562..4119
                     /locus_tag="AI2805V1_5449"
                     /note="long variant; AI2805v1_5449.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="Transposon Tn3 resolvase"
                     /protein_id="CAH5323036.1"
                     /translation="MRIFGYARVSTSQQSLDIQIRALKDAGVKANRIFTDKASGSSTDR
                     EGLDLLRMKVEEGDVILVKKLDRLGRDTADMIQLIKEFDAQGVAVRFIDDGISTDGDMG
                     QMVVTILSAVAQAERRRILERTNEGRQEAKLKGIKFGRRRTVDRNVVLTLHQKGTGATE
                     IAHQLSIARSTVYKILEDERAS"
                     /name="Transposon Tn3 resolvase"
     exon            3562..4119
                     /locus_tag="AI2805V1_5449"
                     /note="AI2805v1_5449.mrna"
                     /number=1
     gene            4302..4907
                     /locus_tag="AI2805V1_5450"
     mRNA            4302..4907
                     /locus_tag="AI2805V1_5450"
                     /note="AI2805v1_5450.mrna"
     CDS             4302..4907
                     /locus_tag="AI2805V1_5450"
                     /note="long variant; AI2805v1_5450.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="Aminoglycoside N(6')-acetyltransferase type 1"
                     /protein_id="CAH5323125.1"
                     /translation="MSIQHFQTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRS
                     HIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGW
                     WEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAI
                     RCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSVA"
                     /name="Aminoglycoside N(6')-acetyltransferase type 1"
     exon            4302..4907
                     /locus_tag="AI2805V1_5450"
                     /note="AI2805v1_5450.mrna"
                     /number=1
     gene            <4989..5246
                     /locus_tag="AI2805V1_5451"
     mRNA            4989..5246
                     /locus_tag="AI2805V1_5451"
                     /note="AI2805v1_5451.mrna"
     CDS             <4989..5246
                     /locus_tag="AI2805V1_5451"
                     /note="short variant; AI2805v1_5451.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="Streptomycin 3''-adenylyltransferase"
                     /protein_id="CAH5323243.1"
                     /translation="VIAEVSTQLSEVVGVIERHLEPTLLAVHLYGSAVDGGLKPHSDID
                     LLVTVTVRLDETTRRALINDLLETALLQIVGGDKLIIPFC"
                     /name="Streptomycin 3''-adenylyltransferase"
     exon            4989..5246
                     /locus_tag="AI2805V1_5451"
                     /note="AI2805v1_5451.mrna"
                     /number=1
     gene            5258..5962
                     /locus_tag="AI2805V1_5452"
     mRNA            5258..5962
                     /locus_tag="AI2805V1_5452"
                     /note="AI2805v1_5452.mrna"
     CDS             5258..5962
                     /locus_tag="AI2805V1_5452"
                     /note="long variant; AI2805v1_5452.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="CAH5323353.1"
                     /translation="MNPFKGRHFQRDIIRWAVRWYCKYGISYRELQEMLAERGVNVDHS
                     TIYRWVQRYAPEMEKRLRWYWRNPSDLCPWHMDETYVKVNGRWAYLYRAVDSRGRTVDF
                     YLSSRRNSKAAYRFLGKILNNVKKWQIPRFINTDKAPAYGRALALLKREGRCPSDVEHR
                     QIKYRNNVIECDHGKLKRIIGATLGFKSMKTAYATIKGIEVMRALRKGQASAFYYGDPL
                     GEMRLVSRVFEM"
                     /name="hypothetical protein"
     exon            5258..5962
                     /locus_tag="AI2805V1_5452"
                     /note="AI2805v1_5452.mrna"
                     /number=1
     gene            <6383..6919
                     /locus_tag="AI2805V1_5453"
     mRNA            6383..6919
                     /locus_tag="AI2805V1_5453"
                     /note="AI2805v1_5453.mrna"
     CDS             <6383..6919
                     /locus_tag="AI2805V1_5453"
                     /note="short variant; AI2805v1_5453.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="Colicin-E3"
                     /protein_id="CAH5323465.1"
                     /translation="VTYNPPHEYGSGWQDQVRYLDKDIQNQNEKLKAAQTSLNEMNESL
                     SRDKAALSGAMESRKQKEKKAKDAENKLNEEKKKPRKGTKDYGHDYFPDPKTEDIKGLG
                     ELKEGKPKTPKQGGGGKRARWYGDKKRKIYEWDSQHGELEGYRASDGEHLGAFDPKTGK
                     QVKGPDPKRNIKKYL"
                     /name="Colicin-E3"
     exon            6383..6919
                     /locus_tag="AI2805V1_5453"
                     /note="AI2805v1_5453.mrna"
                     /number=1
     gene            6929..7186
                     /locus_tag="AI2805V1_5454"
     mRNA            6929..7186
                     /locus_tag="AI2805V1_5454"
                     /note="AI2805v1_5454.mrna"
     CDS             6929..7186
                     /locus_tag="AI2805V1_5454"
                     /note="long variant; AI2805v1_5454.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="Colicin-E3 immunity protein"
                     /protein_id="CAH5323587.1"
                     /translation="MGLKLHIHWFDKKTEEFKGGEYSKDFGDDGSVIESLGMPLKDNIN
                     NGWFDVEKSWVSILQPHFKNVIDISKFDYFVSFVYRDGNW"
                     /name="Colicin-E3 immunity protein"
     exon            6929..7186
                     /locus_tag="AI2805V1_5454"
                     /note="AI2805v1_5454.mrna"
                     /number=1
     gene            8061..8189
                     /locus_tag="AI2805V1_5455"
     mRNA            8061..8189
                     /locus_tag="AI2805V1_5455"
                     /note="AI2805v1_5455.mrna"
     CDS             8061..8189
                     /locus_tag="AI2805V1_5455"
                     /note="long variant; AI2805v1_5455.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="CAH5323690.1"
                     /translation="MEKRHLRGLAVLPHMLVPCLFTESVGNFACVRSARRSLTAGA"
                     /name="hypothetical protein"
     exon            8061..8189
                     /locus_tag="AI2805V1_5455"
                     /note="AI2805v1_5455.mrna"
                     /number=1
     gene            8901..10865
                     /locus_tag="AI2805V1_5456"
     mRNA            8901..10865
                     /locus_tag="AI2805V1_5456"
                     /note="AI2805v1_5456.mrna"
     CDS             8901..10865
                     /locus_tag="AI2805V1_5456"
                     /note="long variant; AI2805v1_5456.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="CAH5323819.1"
                     /translation="MFNTDSLAWKWHIPELARQIYPWVSWLYQEYYGLAGAFLVIGLFF
                     GLAELWAGRMRFVGLSHKERREYADRYKRDNKRPAPFSVLASLDSPGRMVRARRHVWNY
                     AYWLTGAAGLALLGGLVVAVFIESWGETVLRPDLYANADYYLLQPANLFGIAWCAGGLA
                     VGIVLARLLAFLLLDGHFAAADEAVNAKLNQESRRSSQRTGEMTDVRHLHFGEPVPVNA
                     LADFSSEQARQEQAVFLGKDEQGKPVLVPRDTWRKTNIQILGLPGSGKSVMATNALIRC
                     VRDFGDAVVYFDPKGDAWAPHVFRAHCPDFTLLDLRPGKPAQLNLFRDLDQYALKNLLI
                     AGLNLGETGDVADHYRISEQKAAKLIAEQFPQGANIQQVLAAAYALPEALKKDVKGLIT
                     RLENVADLSVLQTDSGIDVAGIINGGGCLYVIGSMDDEAVIRVQKMLFARCAQIIIARD
                     EFREWPHVSVMLDEIKYLLSKYVLNALGTLRSRDCNLLLAHQSLGDFGQCGQDLPAEFV
                     KTTVLDNTPIRWFYRAASLESAQWAAGQTGEIRVDVERRRASREAGNVEHISGDSFIQK
                     EARPLFDVNTLQHLPDGFAVMTGLGVARMAFSSPLRVERREIPLQRFPVLAKTDPLAEF
                     RPPADGGGPKADDDFAGIY"
                     /name="hypothetical protein"
     exon            8901..10865
                     /locus_tag="AI2805V1_5456"
                     /note="AI2805v1_5456.mrna"
                     /number=1
     gene            10865..11596
                     /locus_tag="AI2805V1_5457"
     mRNA            10865..11596
                     /locus_tag="AI2805V1_5457"
                     /note="AI2805v1_5457.mrna"
     CDS             10865..11596
                     /locus_tag="AI2805V1_5457"
                     /note="long variant; AI2805v1_5457.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="CAH5323943.1"
                     /translation="MALELYNVSHAKRQARNAEKTRLTLRWLREELCSTAELVARRLGI
                     AAVQPVYRFLDSLVAKGLLVRTKYPVDGRQVSVWGLTPHGVAFSFDEDEPLADVIPFQP
                     SRVSAAHLPHRLAVQSLRLDMEARGATGWRILHRLSLKGMKVPDALAELDGKTVAFEVE
                     RTVKSRRRYQEVVSGYLFNRKANGIDEIWYICPDRATQVRVQRAILSVDEIVNPQTGEA
                     RKTAELDRERLFACFKFMTTE"
                     /name="hypothetical protein"
     exon            10865..11596
                     /locus_tag="AI2805V1_5457"
                     /note="AI2805v1_5457.mrna"
                     /number=1
     gene            11603..12133
                     /locus_tag="AI2805V1_5458"
     mRNA            11603..12133
                     /locus_tag="AI2805V1_5458"
                     /note="AI2805v1_5458.mrna"
     CDS             11603..12133
                     /locus_tag="AI2805V1_5458"
                     /note="long variant; AI2805v1_5458.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="CAH5324071.1"
                     /translation="MALYMVFIEDAEDRNGERCIMPTSEHLEDMVVLAWQTGAYVFCFV
                     DRAQHLAMMKSIGMYDERLNSDEKATYFFTGKNPQWERNKPTGMKLCDYLYRKVERFAI
                     ENGVQVVDAGKCSPEQINAMIDVVSERHGESAVNEKLKAELMREYNSRYFNVPVPELPE
                     DKPARRWWPFGKK"
                     /name="hypothetical protein"
     exon            11603..12133
                     /locus_tag="AI2805V1_5458"
                     /note="AI2805v1_5458.mrna"
                     /number=1
     gene            complement(12161..12340)
                     /locus_tag="AI2805V1_5459"
     mRNA            complement(12161..12340)
                     /locus_tag="AI2805V1_5459"
                     /note="AI2805v1_5459.mrna"
     CDS             complement(12161..12340)
                     /locus_tag="AI2805V1_5459"
                     /note="long variant; AI2805v1_5459.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="Regulatory protein rop"
                     /protein_id="CAH5324129.1"
                     /translation="MTKQEKTALNMAKFIKEQSLLLLDKLNELDMDTPADMCERLHEDA
                     ETLWQVMRDKLGEE"
                     /name="Regulatory protein rop"
     exon            complement(12161..12340)
                     /locus_tag="AI2805V1_5459"
                     /note="AI2805v1_5459.mrna"
                     /number=1
     gene            12409..12786
                     /locus_tag="AI2805V1_5460"
     mRNA            12409..12786
                     /locus_tag="AI2805V1_5460"
                     /note="AI2805v1_5460.mrna"
     CDS             12409..12786
                     /locus_tag="AI2805V1_5460"
                     /note="long variant; AI2805v1_5460.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="CAH5324195.1"
                     /translation="MAWVTVRQATELTGKARSSLYRDMAKGRVSYRTEADGGRVVDTSE
                     LIRVYGELRQDETHERDELRLSGETEKMASDALIAEIKALREEVAGLRQEMQSMRLLEH
                     KPETAETPAGTPRRWWPWGKR"
                     /name="hypothetical protein"
     exon            12409..12786
                     /locus_tag="AI2805V1_5460"
                     /note="AI2805v1_5460.mrna"
                     /number=1
     gene            complement(12848..13147)
                     /locus_tag="AI2805V1_5461"
     mRNA            complement(12848..13147)
                     /locus_tag="AI2805V1_5461"
                     /note="AI2805v1_5461.mrna"
     CDS             complement(12848..13147)
                     /locus_tag="AI2805V1_5461"
                     /note="long variant; AI2805v1_5461.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="CAH5324330.1"
                     /translation="MPYDVEWKQGAIEDVTTLFDYIAENSSLWDAQNVTDRVLAAADKL
                     ADFPRLYEVDSRYGEDVRRISLMGQHVLYDVDDQTRKVRVLAVVGQRQNPHIVL"
                     /name="hypothetical protein"
     exon            complement(12848..13147)
                     /locus_tag="AI2805V1_5461"
                     /note="AI2805v1_5461.mrna"
                     /number=1
     gene            complement(13137..13400)
                     /locus_tag="AI2805V1_5462"
     mRNA            complement(13137..13400)
                     /locus_tag="AI2805V1_5462"
                     /note="AI2805v1_5462.mrna"
     CDS             complement(13137..13400)
                     /locus_tag="AI2805V1_5462"
                     /note="long variant; AI2805v1_5462.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="CAH5324541.1"
                     /translation="MSNTTHYENANFLRELAESLPRILPEGGPDKAALLQRLANEELAQ
                     AEYEDQVRAKVTAARADTRPGMTTEQLRQRLHGRYQELRDAV"
                     /name="hypothetical protein"
     exon            complement(13137..13400)
                     /locus_tag="AI2805V1_5462"
                     /note="AI2805v1_5462.mrna"
                     /number=1
     ARG             4354..4904
                     /name="aac(6')-Ib"
                     /gene="aac(6')-Ib"
                     /gene_name="AAC(6')-Ib family aminoglycoside
                     6'-N-acetyltransferase"
                     /tool="amrfinderplus"
                     /drug_class="AMINOGLYCOSIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             4990..5246
                     /name="aadA15"
                     /gene="aadA15"
                     /gene_name="ANT(3'')"
                     /tool="rgi"
                     /drug_class="aminoglycoside antibiotic"
                     /identity="97.14"
                     /coverage="32.32"
     ARG             4303..4907
                     /name="AAC(6')-Ib10"
                     /gene="AAC(6')-Ib10"
                     /gene_name="AAC(6')"
                     /tool="rgi"
                     /drug_class="aminoglycoside antibiotic"
                     /identity="98.97"
                     /coverage="99.01"
     Typing          complement(7524..8102)
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="95.361"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          10866..11593
                     /name="MOBC"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="1.34e-150"
ORIGIN
        1 ccgtagccgc cggaaacgcc ctgagcccgt ctgagcggtg cgcgtaatga cgcgttatgg
       61 taaatccact tactgtctgc cttcatagcc atcgagataa acagctgaaa tggtgtcagc
      121 cagtagcctt gattttttcg gtgtgaggtc tttgctgcgg taatcggtac ccgcaaattg
      181 tgttgtgcct tggagtgagt ttaaaaattc ctgactgtga aactgctgaa tgcgttgctg
      241 cacatcactc cgtgattttc cggtcgcttt atcctttgcg cccatatccc agaactgccg
      301 gaaaaaaggc accatcattc gtgttgtgtc agctttctgg gtggaaaaat tgggatcaaa
      361 aggggtctga cgctcagtgg aacgaaaact cacgttaagc aacgttttct gcctctgacg
      421 cctcttttaa tggtctcaga tgacctttgg tcaccagttc tgccagcgtg aaggaataat
      481 ggccgagcat attgatatgt ccgtggcaaa gcggggagag gcgtgcgata tcttcatcat
      541 tcagtgtttc accctgcgcc cggagatgat ccagagctgc ctgcatataa atagtgttcc
      601 ataacacgac ggcgttagtg accagcccca gagctcccaa ctgatcttcc tgaccgtcgg
      661 tatatcgttt tcttatctca cctttttgac cgtgacagat ggctctggca actgcatgac
      721 ggctttctcc ccgattaagc tgggtcagaa tgcgccggcg gtaatcttca tcatcaatat
      781 aattaagcag atacagcgtt ttgttgatgc gccccacttc aatgattgcc tgagtcagtc
      841 cggagggacg ttcacttttc agcaatgaac ggaccagcac tgaggcctgt actttgccca
      901 gcttcaggga gcctgcggtc cggatcattt cgtcccactg aaggactatt tttcggggat
      961 ctgattgccc tctggcaata tcattcagca cgccatagtc ggcatcatgg tccattcgcc
     1021 agaaaaccga agcaccggca tcagccaggc gtggagaaaa ctggtatccc agcagccaga
     1081 aaaggccaaa gacaagatcg ctggcacctg ccgtatcggt cataatttcg gttggattca
     1141 gcccggtctc ctgttccaga aggccttcca gcacaaagat agagtccctc agcgtccccg
     1201 gtataacgat gccatgaaag ccggaatact gatcggacac aaagttgtac caggtgatcc
     1261 ctctgttatt accaaagtat ttgcggttcg gtccggcatt gattgttctg actggcgtaa
     1321 caaagcgcat tccatctgca gatgccactt ctcctccacc ccatatctgt gccagtggca
     1381 gcgttgcctg aaaatcaacc agtctggcat tagcgctggt gatagtttca gcccgcagat
     1441 agttcgcttt tgtccagttc agccggtgtc gggtcagtgc aggaacattt gatctgatca
     1501 gtggttccag accgatattg caggcttcag ccatcagcac ggcgctgatg ctgacgggca
     1561 gatcatcaac tctggcactg gcttcactgg catggaaaaa ctcatcagca aatccggtat
     1621 gggcgttaat ttcgagcagc aactccgtta aatccaccgg agggagcaga tcactgatca
     1681 ttttgctcag tcgtttcaga ctgtccggct catcaagact ggcgagggga gaaattgtca
     1741 accggggctt cgggccagaa acatcgagtt cgacagcctc attttcgcca agacgtgcag
     1801 caacctgtct gtaacgacta tcaagctgat ggcccagaga ttttattgct tcctgcgggt
     1861 ctgtcgggtg ccccaaagaa cgataaacct taatccgatt tgcctgccag tcagcaccct
     1921 gtagtaatct tgcacgagga tctccccacc ggttactgcc ggtaacgtag acatccctcc
     1981 gtctcagact atcctgcagt ttactgagaa agcagagcgt gtatcccctt cgggtgatat
     2041 gtttttcctt gttaatcacc agccgtttcc atgactgact gatgatttcc gttggtgcgt
     2101 cgtcaaaaaa ctgccgccgt gagctgaact cccggctgag gtagtcacag gcattcagag
     2161 tggtaacccc ggcaggtgcg gatgaaaatt taacggtatt cagcagatgg ggcaggaaac
     2221 gacgaacgcg cccgtactgc tccaccattt cgtcatgaaa attatcgtct gagggccggg
     2281 caatttcacg gacaagcgtg atgatttcag ccagcttttg cctagggatg tagctgaaca
     2341 cctcagcacg aatcgattcg tccggtgttt cttctttcag caagtacgaa catgcgctgg
     2401 cgagcgccaa tgcagattta tccagatcct tcagcgagcg gagccgtttt ttctgcccaa
     2461 tctttctggc gtcacggatg ataacggcca gcatggcgtc cagaacgtcc agtgcatcat
     2521 ccagcgccag cgtttcccat gcaaggacaa aggcaaccag aaccgccatc cttttctgcg
     2581 gtgacatcct ggcaatattg aacaccgaag tcataccagc ataacgtgcg agatttttca
     2641 ggcgcacagc cgggagtgta ctcaggtttt cagcatgcag gccaaaatcg ttcagagttt
     2701 tccagcgttc aattgcttca ttaaacgccg gaccactgat ggtcacaggg ccttttttca
     2761 gtgattccag taaagacagg cggctgcaat cagttggccc cagcagcatc tccagctgtg
     2821 aacgctgttc ggctgacggt atcagtgcca gtttgttcca caggcgcaac gtcgcctttt
     2881 cccttacctc tgaaatcaac cgggtcagcg tggtggctcc ggggagaata atacgatgtt
     2941 gcataagcca ccctgtcgcc aggtcgaaaa gcaggccagg acgttcgttg cttatccagc
     3001 tccgggtata taaaagacgg gtaaggcgaa atgtccaggg ccaggcaaat tcacgatact
     3061 gatagtgctg acgtatcagc gctgcatgct cacggcgggt attttccctc tgaccgtatt
     3121 ctgcaagaac ggtgatatca cgaatcccga gctgtctggc ggtaaaatgc cggacgccgg
     3181 aaggaatatg attcatgtca gtaagaaaag tgcccagaaa acgcacacac ccgatttgca
     3241 gggcaatacc aagtcgattg tgatcacccc ggcttttccc gataaattct ttatccgctt
     3301 catcaagatg aaaataacgc gccagctgaa gttcatcggg ttcgccagtg aacctgccat
     3361 aactctcaac ctgctcagtg gtcaaaaaat caacgggcat atcggcctcc ctgcctgacg
     3421 gcttttttaa cacaactgca accgttcgaa atattataaa ttatcagaca tagtaaaacg
     3481 gcttcgtttg agtgtccatt aaatcgtcat tttggcataa tagacacatc gtgtctgata
     3541 ttcgatttaa ggtacatttt tatgcgaatt tttggttatg cgcgggtctc aaccagccag
     3601 cagtccctcg atattcagat cagagcgctc aaagatgcag gggtaaaagc taaccgcatc
     3661 tttaccgaca aggcatccgg cagttcaaca gatcgggaag ggctggattt gctgaggatg
     3721 aaggtggagg aaggtgatgt cattctggtg aagaagctcg accgtcttgg ccgcgacacc
     3781 gccgacatga tccaactgat aaaagagttt gatgctcagg gtgtagcggt tcggtttatt
     3841 gacgacggga tcagtaccga cggtgatatg gggcaaatgg tggtcaccat cctgtcggct
     3901 gtggcacagg ctgaacgccg gaggatccta gagcgcacga atgagggccg acaggaagca
     3961 aagctgaaag gaatcaaatt tggccgcagg cgtaccgtgg acaggaacgt cgtgctgacg
     4021 cttcatcaga agggcactgg tgcaacggaa attgctcatc agctcagtat tgcccgctcc
     4081 acggtttata aaattcttga agacgaaagg gcctcgtgat acgcctattt ttataggtta
     4141 atgtcatgat aataatggtt tcttagacgt caggtggcac ttttcgggga aaagtgcgcg
     4201 gaacccctat ttgtttattt ttctaaatac attcaaatat gtatccgctc atgagacaat
     4261 aaccctgata aatgcttcaa taatattgaa aaaggaagag tatgagtatt caacatttcc
     4321 aaacaaagtt aggcatcaca aagtacagca tcgtgaccaa cagcaacgat tccgtcacac
     4381 tgcgcctcat gactgagcat gaccttgcga tgctctatga gtggctaaat cgatctcata
     4441 tcgtcgagtg gtggggcgga gaagaagcac gcccgacact tgctgacgta caggaacagt
     4501 acttgccaag cgttttagcg caagagtccg tcactccata cattgcaatg ctgaatggag
     4561 agccgattgg gtatgcccag tcgtacgttg ctcttggaag cggggacgga tggtgggaag
     4621 aagaaaccga tccaggagta cgcggaatag accagttact ggcgaatgca tcacaactgg
     4681 gcaaaggctt gggaaccaag ctggttcgag ctctggttga gttgctgttc aatgatcccg
     4741 aggtcaccaa gatccaaacg gacccgtcgc cgagcaactt gcgagcgatc cgatgctacg
     4801 agaaagcggg gtttgagagg caaggtaccg taaccacccc agatggtcca gccgtgtaca
     4861 tggttcaaac acgccaggca ttcgagcgaa cacgcagtgt tgcctaaccc ttccatcgag
     4921 ggggacgtcc aagggctggc gcccttggcc gcccctcatg tcaaacgtta aacatcatga
     4981 gggaagcggt gatcgccgaa gtatcgactc aactatcaga ggtagttggc gtcatcgagc
     5041 gccatctcga accgacgttg ctggccgtac atttgtacgg ctccgcagtg gatggcggcc
     5101 tgaagccaca cagtgatatt gatttgctgg ttacggtgac cgtaaggctt gatgaaacaa
     5161 cgcggcgagc tttgatcaac gaccttttgg aaacggcact gttgcaaata gtcggtggtg
     5221 ataaacttat catccccttt tgctgatgga gctgcacatg aacccattca aaggccggca
     5281 ttttcagcgt gacatcattc ggtgggccgt acgctggtac tgcaaatacg gcatcagtta
     5341 ccgtgagctg caggagatgc tggctgaacg cggagtgaat gtcgatcact ccacgattta
     5401 ccgctgggtt cagcgttatg cgcctgaaat ggaaaaacgg ctgcgctggt actggcgtaa
     5461 cccttccgat ctttgcccgt ggcacatgga tgaaacctac gtgaaggtca atggccgctg
     5521 ggcgtatctg taccgggccg tcgacagccg gggccgcact gtcgattttt atctctcctc
     5581 ccgtcgtaac agcaaagctg cataccggtt tctgggtaaa atcctcaaca acgtgaagaa
     5641 gtggcagatc ccgcgattca tcaacacgga taaagcgccc gcctatggtc gcgcgcttgc
     5701 tctgctcaaa cgcgaaggcc ggtgcccgtc tgacgttgaa caccgacaga ttaagtaccg
     5761 gaacaacgtg attgaatgcg atcatggcaa actgaaacgg ataatcggcg ccacgctggg
     5821 atttaaatcc atgaagacgg cttacgccac catcaaaggt attgaggtga tgcgtgcact
     5881 acgcaaaggc caggcctcag cattttatta tggtgatccc ctgggcgaaa tgcgcctggt
     5941 aagcagagtt tttgaaatgt aaggcctttg aataagacaa aaggctgcct catcgctaac
     6001 tttgcaacag tgccctgata aatctggagc cggtgagcgt gggtctcgcg gtatcattgc
     6061 agcactgggg ccagatggta agccctcccg tatcgtagtt atctacacga cggggagtca
     6121 ggcaactatg gatgaacgaa atagacagat cgctgagata ggtgcctcac tgattaagca
     6181 ttggtaactg tcagaccaag tttactcata tatactttag attgatttaa aacttcattt
     6241 ttaatttaaa aggatctagg tgaagatcct ttttgataat ctcatgacca aaatccctta
     6301 acgtgagttt tcgttccact gagcgtcaga ccccgaagcc gataaaaagg taaaagaggc
     6361 agaggcaaat aaagatgatt ttgtgactta taacccgcct catgaatatg gctccgggtg
     6421 gcaggatcag gttcgctatc ttgataagga tattcagaat cagaatgaga aattaaaagc
     6481 tgcccagaca tctttaaacg aaatgaatga atccttatcc agggataagg ctgcgctttc
     6541 cggggcgatg gagagccgga aacaaaagga gaaaaaagcg aaggatgcag aaaataaatt
     6601 aaatgaggaa aagaaaaaac ctcgtaaggg aactaaagat tacggccatg attattttcc
     6661 tgatcccaag actgaagata ttaaggggtt gggagagttg aaagagggta aacctaaaac
     6721 ccctaaacaa ggtggtggtg gtaagcgggc ccgatggtat ggtgataaaa agcgtaaaat
     6781 ttatgaatgg gattcccagc acggtgagct tgaagggtac cgcgccagtg atggcgaaca
     6841 cctcggggca ttcgatccaa aaacgggtaa gcaggttaaa gggccggatc caaaacgaaa
     6901 cattaaaaaa tatctttaag aggtaaatat ggggcttaaa ttacatattc attggtttga
     6961 taagaaaacc gaagagttta aaggtggtga atactcaaaa gacttcggtg atgatggttc
     7021 tgtcattgaa agtctgggga tgcctttaaa ggataatatt aataatggtt ggtttgatgt
     7081 tgaaaaatca tgggtttcga tattacagcc acactttaaa aatgtaatcg atattagtaa
     7141 atttgattac tttgtatcct ttgtttaccg ggatggtaac tggtaagcaa aagttatcaa
     7201 ggatgatttg aaatacagac ttccggtgtt cagggatgaa taccggggtt tttaaataca
     7261 gggaaggtat atgaaaaagg taaaggttgt ttttcttttt atattgattt tttcaggctt
     7321 tcttctggtc gcatgtcagg caaactatat ccgggatgtt cagggtggaa cggtggcacc
     7381 atcgtcctcc tctgaactga cggggatcgc ggttcagtag aaaagatcaa aggatcttct
     7441 tgagatcctt tttttctgcg cgtaatcttt tgccctgtaa acgaaaaaac cacctgggga
     7501 ggtggtttga tcgaaggtta agtcagttgg ggaactgctt aaccgtggta actggctttc
     7561 gcagagcaca gcaaccaaat ctgtccttcc agtgtagccg gactttggcg cacacttcaa
     7621 gagcaaccgc gtgtttagct aaacaaatcc tctgcgaact cccagttacc aatggctgct
     7681 gccagtggcg ttttgcgtgc ttttccgggt tggactcaag tgaacagtta ccggataagg
     7741 cgcagcagtc gggctgaacg gggggttctt gcttacagcc cagcttggag cgaacgacct
     7801 acaccgagcc gagataccag agtgtgagct atgagaaagc gccacacttc ccgcaaggga
     7861 gaaaggcgga acaggtatcc gggaaacggc agggttggaa caggagagcg caagagggag
     7921 cgattcatcg gaaacggtga tgatctttaa gtcctgtcgg gtttcgccac tcctgactga
     7981 ttcatggttg agccaccggc tcccacagat gcaccgaaaa agcgtctgtt tatgtgaact
     8041 cagtcaggag ggcggagcct atggaaaaac gccacctgcg tggccttgcc gttttgcctc
     8101 acatgttagt cccctgctta ttcacggaat ctgtgggtaa ctttgcatgt gtccgcagcg
     8161 cccgccgcag tctcacggcc ggagcgtagc gaccgagtga gcgaggaggc gcaatttccc
     8221 cggcacctac aagacggaca ccggacgcgc tgatgtggca tattgtcccc tgattaagtc
     8281 tttatattcc ctgataataa attaccagga taggtgaatc atatcggttt ttcgctgaac
     8341 attttacgtt aacctatctc tgttgctttt ttctccttac ggagaaatac aggtcatccc
     8401 cgcgagggcg tggctgacct cagggggata tcccctgctt acgctggctg gacgccaccg
     8461 acgcacggtc tctccccctc tttctggctc cgtccggctg gacgccggcc acgccagaaa
     8521 ttcacccggc ccccgtcagg ctcacgcctg accacccaca aaaatccacg gtgctggacg
     8581 cacctggcga agcagcaaag ctgctcctga ttttgcgggt ggtcagccgc tcgctatggc
     8641 gaactctgac gggggccgga acaccggaaa agaccgcact ggggtgccgc cttttcctct
     8701 cacacgctgg ggcgtgctcg ttgttcctcc ggggctgcgc cttttccgca tggggcggaa
     8761 agaggctggc ctccgtggtg aaagctgaac gcaatcacca cggacgtgac cgccgccgcc
     8821 atgccttggg gcatgtccgc ggcttgtgca gcgggggctg cacatcacgc cggcaaacca
     8881 tcgtctgaag gagagagaac atgtttaata cggattcgct tgcctggaag tggcacattc
     8941 cggagctggc ccggcagatt tatccgtggg tcagctggct gtaccaggag tattacggtc
     9001 tggccggggc tttcctagtt atcggcctgt ttttcggtct ggctgaactt tgggccggac
     9061 ggatgcgttt tgtggggctg agtcataagg agcgacggga gtatgccgat cgctataagc
     9121 gcgataataa acggccagcg ccattttcgg tgctggcctc gctggattcg cccgggcgga
     9181 tggtcagggc acgtcgacat gtctggaact acgcgtactg gctgaccggc gcggccggtc
     9241 tggcccttct gggggggctg gttgtcgccg tgtttatcga gagctgggga gaaaccgtcc
     9301 tgcgtccgga cctctacgca aacgcagatt attacctgct gcagccggct aacctgttcg
     9361 ggattgcctg gtgcgcgggc gggctggctg tcgggattgt gttggcgcgg ctgctggcgt
     9421 tcctgctgct tgacggtcat tttgcggctg ctgacgaggc ggtgaacgcg aaactgaatc
     9481 aggagagccg gcgcagcagc cagcggacag gagagatgac cgacgtgcgc cacctgcatt
     9541 tcggggagcc ggtaccggtt aatgcgctgg ccgatttttc ctcggagcag gcccggcagg
     9601 agcaggcggt gtttctgggt aaggatgagc agggcaagcc ggtgctggtt ccgcgtgata
     9661 cctggcgcaa gaccaacatt cagatcctcg gcctgcccgg gagcggcaag agcgtgatgg
     9721 ccaccaacgc gctcattcgc tgcgtacgcg atttcgggga cgcggtggtg tacttcgacc
     9781 ccaaagggga cgcatgggcg ccgcacgtct tccgggcgca ctgtccggac ttcaccctgc
     9841 tggatctgcg gccggggaaa ccggcgcagc tgaatctgtt ccgcgatctc gaccagtacg
     9901 cgctgaaaaa cctgctgatt gccgggctta acctgggcga gaccggcgac gtggcggacc
     9961 actaccgcat cagcgagcag aaagcggcga agctgattgc ggagcagttt ccgcaggggg
    10021 caaacattca gcaggtgctg gcggcggcgt acgcgctgcc ggaggccctg aaaaaggacg
    10081 tgaaggggtt gatcactagg ctggaaaacg tcgctgacct gagcgtcctg cagacggaca
    10141 gtggcatcga tgtggcgggg attatcaacg gcggcggctg cctgtacgtt atcggctcga
    10201 tggacgacga ggcggtgatc cgtgtgcaaa aaatgctgtt tgcccgctgc gcgcaaatca
    10261 tcattgcgcg ggacgagttc cgggagtggc cacacgtcag cgtgatgctc gatgaaatta
    10321 aatatctgct gtcgaagtat gtactgaacg cactggggac gctgcgcagc cgggactgca
    10381 atctgttgct cgcgcaccag tcgctgggcg atttcgggca gtgcgggcag gatctgcccg
    10441 ctgaatttgt gaaaaccacg gtactggata acacgccgat ccgctggttt taccgggcgg
    10501 ccagcctgga gtccgcgcag tgggcggcgg ggcagaccgg ggaaatcagg gtggacgtgg
    10561 agcgccgccg tgccagccgg gaggcgggga acgtggagca tatcagcggg gacagcttca
    10621 tccagaagga ggcgcggccg ctgtttgacg tgaacaccct gcaacacctg ccggacgggt
    10681 tcgcggtcat gaccgggctg ggtgtggccc ggatggcgtt cagcagtccg ctgcgggttg
    10741 agcgccggga aatcccgttg cagcgtttcc cggtgctggc gaaaaccgat cccctggcgg
    10801 agttccggcc cccggccgac ggcggcgggc cgaaagcgga tgatgatttt gcggggattt
    10861 actgatggcg ctggagctgt acaacgtcag ccacgcgaaa cgacaggcgc ggaacgcgga
    10921 gaaaacccgg ctgaccctgc gctggttgcg ggaagagctg tgttccacgg cggagctggt
    10981 tgcgcggcgg ctggggattg cggcggtgca gccggtctac cgcttcctcg acagcctggt
    11041 ggcgaaaggg ctgctggtcc ggaccaaata tccggtggac ggccgtcagg tcagcgtgtg
    11101 ggggctgacg ccgcatggcg tggcgttctc gttcgacgag gacgaaccgc tggcggatgt
    11161 tattccgttt cagccgtcaa gggtgtcggc agcacatctg ccgcaccggc tggccgtgca
    11221 atccctgcgc cttgatatgg aagccagagg ggccaccggc tggcgcattc tgcaccgtct
    11281 gagtcttaaa ggcatgaaag tgccggacgc cctggcggag ctggacggta aaacggtggc
    11341 gtttgaggtg gagcgcaccg tcaagagccg tcgccggtat caggaagtgg tgtccgggta
    11401 tctgttcaac cgcaaagcta acggcatcga tgaaatctgg tacatctgcc cggaccgggc
    11461 gacgcaggtc agggtgcagc gggcaatcct gtcggtggat gaaatcgtga acccacagac
    11521 cggcgaggcc cgcaaaacgg cagagctgga tcgtgaacgg ttgtttgcgt gctttaaatt
    11581 tatgacaacg gagtgaggga ttatggcgct gtacatggta tttattgaag acgcggagga
    11641 ccggaacggc gagcgctgca tcatgccgac cagcgagcat ctggaagata tggtggtgct
    11701 cgcctggcag accggggcgt atgttttctg ttttgtcgac cgggcccagc atctggcgat
    11761 gatgaaatcc atcgggatgt atgacgagcg gctcaacagc gacgaaaaag ccacgtactt
    11821 tttcactggt aaaaatccgc aatgggaacg gaacaaaccc acaggaatga agctgtgtga
    11881 ttacctctat cgcaaggtgg agcggttcgc catcgagaac ggtgtgcagg tggttgatgc
    11941 cgggaagtgc tcaccggagc agattaacgc gatgattgac gtggtgagtg agcggcacgg
    12001 ggaaagcgcg gtgaacgaga agctgaaagc ggagctgatg cgggaatata acagccgcta
    12061 ttttaacgtg ccggtacctg aactgccgga ggacaaacct gcccgccggt ggtggccgtt
    12121 cggcaaaaaa taaatgccag caccggccat gccggtgctg ttattcctcc ccgagcttat
    12181 cccgcatcac ctgccagagt gtttccgcat cctcgtgtag ccgctcgcac atgtcggccg
    12241 gggtatccat atccagctca ttcagtttat cgagcaatag cagcgactgc tccttaataa
    12301 atttagccat attgagggct gttttttcct gttttgtcat gattctttcc ttccgggcat
    12361 ggtgtgcgcc tgtcaggtat actgtctcaa aaatagcggg gtgagacaat ggcgtgggtg
    12421 acggtgagac aggcgacgga actgacgggt aaagcccgaa gttccctgta tcgggatatg
    12481 gcgaaaggcc gcgtatcata ccgtacggaa gctgatggcg gccgggtggt ggataccagc
    12541 gagcttatcc gggtgtacgg tgagttaaga caggatgaga ctcacgagcg ggacgagttg
    12601 agactgtcgg gtgagactga aaaaatggcc tccgacgcgt tgatcgcgga gataaaagca
    12661 ctcagggagg aggtggccgg gctacggcag gaaatgcagt ccatgagact gctggaacac
    12721 aaaccggaga cagcagagac cccggccgga acaccgcgcc ggtggtggcc gtggggaaaa
    12781 cgctgacgcg ctgtgcttgt ccaaccggcg acggccacgc aatgaattgc gtccccgtca
    12841 ccggttatta gagaacaata tggggattct ggcgctggcc gaccacggcc agaacccgga
    12901 cttttctggt ctggtcatca acatcataga ggacatgctg tcccatcaga ctgatccggc
    12961 gaacgtcctc gccatagcgt gagtccactt catagagtcg cgggaagtcg gccagtttgt
    13021 ccgccgcagc gagaacccgg tcggtaacgt tctgcgcatc ccacagggat gaattttccg
    13081 cgatatagtc aaacagcgtc gttacatcct cgatggctcc ctgcttccat tccacgtcat
    13141 acggcatcgc gcagttcctg ataacggcca tgcaggcgct ggcggagttg ttccgtggtc
    13201 atacccggac gcgtgtcagc acgggcggcg gtcactttgg cgcgaacctg atcttcatac
    13261 tctgcctggg ccagttcttc gttagccagt cgctgcaaca gcgcagcttt gtccgggcca
    13321 ccttccggca gtatgcgggg caggctttca gccagttccc gaagaaagtt ggcgttttcg
    13381 tagtgtgtag tgttgctcat tgcggagcct cccgggttaa tgcggcaata tgaaggaagt
    13441 ttagcagggg gcggtctgaa agaatatggt cgtgtcagtc aggctgatga agcagaaagt
    13501 cggtaaaaaa gggcttacgg catccatttt acgtcaaaac atatgccatg cagttgcgtg
    13561 cataggcatg cattaggata aaatttatcg ggcgcgtttc cggcagtttt ccgggggggt
    13621 tgttgcctgt tttatc
//
