LOCUS       OW848956               13636 bp    DNA     circular BCT 17-MAY-2022
DEFINITION  Klebsiella pneumoniae isolate 512 genome assembly, plasmid: P3.
ACCESSION   OW848956
VERSION     OW848956.1
DBLINK      BioProject: PRJEB42440
            BioSample: SAMEA7853281
KEYWORDS    .
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1
  AUTHORS   Alioto,T., Alioto,T. and Gomez Garrido,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-MAY-2022) CNAG-CRG, CNAG, Spain
FEATURES             Location/Qualifiers
     source          1..13636
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
                     /isolate="512"
                     /isolation_source="Hospital General La Mancha Centro
                     (Ciudad Real)"
                     /db_xref="taxon:573"
                     /plasmid="P3"
     gene            complement(179..883)
                     /locus_tag="AI2714V1_5447"
     mRNA            complement(179..883)
                     /locus_tag="AI2714V1_5447"
                     /note="AI2714v1_5447.mrna"
     CDS             complement(179..883)
                     /locus_tag="AI2714V1_5447"
                     /note="long variant; AI2714v1_5447.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="CAH3836580.1"
                     /translation="MNPFKGRHFQRDIIRWAVRWYCKYGISYRELQEMLAERGVNVDHS
                     TIYRWVQRYAPEMEKRLRWYWRNPSDLCPWHMDETYVKVNGRWAYLYRAVDSRGRTVDF
                     YLSSRRNSKAAYRFLGKILNNVKKWQIPRFINTDKAPAYGRALALLKREGRCPSDVEHR
                     QIKYRNNVIECDHGKLKRIIGATLGFKSMKTAYATIKGIEVMRALRKGQASAFYYGDPL
                     GEMRLVSRVFEM"
                     /name="hypothetical protein"
     exon            complement(179..883)
                     /locus_tag="AI2714V1_5447"
                     /note="AI2714v1_5447.mrna"
                     /number=1
     gene            complement(895..>1152)
                     /locus_tag="AI2714V1_5448"
     mRNA            complement(895..1152)
                     /locus_tag="AI2714V1_5448"
                     /note="AI2714v1_5448.mrna"
     CDS             complement(895..>1152)
                     /locus_tag="AI2714V1_5448"
                     /note="short variant; AI2714v1_5448.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="Streptomycin 3''-adenylyltransferase"
                     /protein_id="CAH3836675.1"
                     /translation="VIAEVSTQLSEVVGVIERHLEPTLLAVHLYGSAVDGGLKPHSDID
                     LLVTVTVRLDETTRRALINDLLETALLQIVGGDKLIIPFC"
                     /name="Streptomycin 3''-adenylyltransferase"
     exon            complement(895..1152)
                     /locus_tag="AI2714V1_5448"
                     /note="AI2714v1_5448.mrna"
                     /number=1
     gene            complement(1234..1839)
                     /locus_tag="AI2714V1_5449"
     mRNA            complement(1234..1839)
                     /locus_tag="AI2714V1_5449"
                     /note="AI2714v1_5449.mrna"
     CDS             complement(1234..1839)
                     /locus_tag="AI2714V1_5449"
                     /note="long variant; AI2714v1_5449.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="Aminoglycoside N(6')-acetyltransferase type 1"
                     /protein_id="CAH3836774.1"
                     /translation="MSIQHFQTKLGITKYSIVTNSNDSVTLRLMTEHDLAMLYEWLNRS
                     HIVEWWGGEEARPTLADVQEQYLPSVLAQESVTPYIAMLNGEPIGYAQSYVALGSGDGW
                     WEEETDPGVRGIDQLLANASQLGKGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAI
                     RCYEKAGFERQGTVTTPDGPAVYMVQTRQAFERTRSVA"
                     /name="Aminoglycoside N(6')-acetyltransferase type 1"
     exon            complement(1234..1839)
                     /locus_tag="AI2714V1_5449"
                     /note="AI2714v1_5449.mrna"
                     /number=1
     gene            complement(2022..2579)
                     /locus_tag="AI2714V1_5450"
     mRNA            complement(2022..2579)
                     /locus_tag="AI2714V1_5450"
                     /note="AI2714v1_5450.mrna"
     CDS             complement(2022..2579)
                     /locus_tag="AI2714V1_5450"
                     /note="long variant; AI2714v1_5450.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="Transposon Tn3 resolvase"
                     /protein_id="CAH3836880.1"
                     /translation="MRIFGYARVSTSQQSLDIQIRALKDAGVKANRIFTDKASGSSTDR
                     EGLDLLRMKVEEGDVILVKKLDRLGRDTADMIQLIKEFDAQGVAVRFIDDGISTDGDMG
                     QMVVTILSAVAQAERRRILERTNEGRQEAKLKGIKFGRRRTVDRNVVLTLHQKGTGATE
                     IAHQLSIARSTVYKILEDERAS"
                     /name="Transposon Tn3 resolvase"
     exon            complement(2022..2579)
                     /locus_tag="AI2714V1_5450"
                     /note="AI2714v1_5450.mrna"
                     /number=1
     gene            2741..5746
                     /locus_tag="AI2714V1_5451"
     mRNA            2741..5746
                     /locus_tag="AI2714V1_5451"
                     /note="AI2714v1_5451.mrna"
     CDS             2741..5746
                     /locus_tag="AI2714V1_5451"
                     /note="long variant; AI2714v1_5451.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="CAH3836984.1"
                     /translation="MPVDFLTTEQVESYGRFTGEPDELQLARYFHLDEADKEFIGKSRG
                     DHNRLGIALQIGCVRFLGTFLTDMNHIPSGVRHFTARQLGIRDITVLAEYGQRENTRRE
                     HAALIRQHYQYREFAWPWTFRLTRLLYTRSWISNERPGLLFDLATGWLMQHRIILPGAT
                     TLTRLISEVREKATLRLWNKLALIPSAEQRSQLEMLLGPTDCSRLSLLESLKKGPVTIS
                     GPAFNEAIERWKTLNDFGLHAENLSTLPAVRLKNLARYAGMTSVFNIARMSPQKRMAVL
                     VAFVLAWETLALDDALDVLDAMLAVIIRDARKIGQKKRLRSLKDLDKSALALASACSYL
                     LKEETPDESIRAEVFSYIPRQKLAEIITLVREIARPSDDNFHDEMVEQYGRVRRFLPHL
                     LNTVKFSSAPAGVTTLNACDYLSREFSSRRQFFDDAPTEIISQSWKRLVINKEKHITRR
                     GYTLCFLSKLQDSLRRRDVYVTGSNRWGDPRARLLQGADWQANRIKVYRSLGHPTDPQE
                     AIKSLGHQLDSRYRQVAARLGENEAVELDVSGPKPRLTISPLASLDEPDSLKRLSKMIS
                     DLLPPVDLTELLLEINAHTGFADEFFHASEASARVDDLPVSISAVLMAEACNIGLEPLI
                     RSNVPALTRHRLNWTKANYLRAETITSANARLVDFQATLPLAQIWGGGEVASADGMRFV
                     TPVRTINAGPNRKYFGNNRGITWYNFVSDQYSGFHGIVIPGTLRDSIFVLEGLLEQETG
                     LNPTEIMTDTAGASDLVFGLFWLLGYQFSPRLADAGASVFWRMDHDADYGVLNDIARGQ
                     SDPRKIVLQWDEMIRTAGSLKLGKVQASVLVRSLLKSERPSGLTQAIIEVGRINKTLYL
                     LNYIDDEDYRRRILTQLNRGESRHAVARAICHGQKGEIRKRYTDGQEDQLGALGLVTNA
                     VVLWNTIYMQAALDHLRAQGETLNDEDIARLSPLCHGHINMLGHYSFTLAELVTKGHLR
                     PLKEASEAENVA"
                     /name="hypothetical protein"
     exon            2741..5746
                     /locus_tag="AI2714V1_5451"
                     /note="AI2714v1_5451.mrna"
                     /number=1
     gene            <5739..6071
                     /locus_tag="AI2714V1_5452"
     mRNA            5739..6071
                     /locus_tag="AI2714V1_5452"
                     /note="AI2714v1_5452.mrna"
     CDS             <5739..6071
                     /locus_tag="AI2714V1_5452"
                     /note="short variant; AI2714v1_5452.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="CAH3837081.1"
                     /translation="LLNVSFRSTERQTPFDPNFSTQKADTTRMMVPFFRQFWDMGAKDK
                     ATGKSRSDVQQRIQQFHSQEFLNSLQGTTQFAGTDYRSKDLTPKKSRLLADTISAVYLD
                     GYEGRQ"
                     /name="hypothetical protein"
     exon            5739..6071
                     /locus_tag="AI2714V1_5452"
                     /note="AI2714v1_5452.mrna"
                     /number=1
     gene            6377..6640
                     /locus_tag="AI2714V1_5453"
     mRNA            6377..6640
                     /locus_tag="AI2714V1_5453"
                     /note="AI2714v1_5453.mrna"
     CDS             6377..6640
                     /locus_tag="AI2714V1_5453"
                     /note="long variant; AI2714v1_5453.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="CAH3837180.1"
                     /translation="MSNTTHYENANFLRELAESLPRILPEGGPDKAALLQRLANEELAQ
                     AEYEDQVRAKVTAARADTRPGMTTEQLRQRLHGRYQELRDAV"
                     /name="hypothetical protein"
     exon            6377..6640
                     /locus_tag="AI2714V1_5453"
                     /note="AI2714v1_5453.mrna"
                     /number=1
     gene            6630..6929
                     /locus_tag="AI2714V1_5454"
     mRNA            6630..6929
                     /locus_tag="AI2714V1_5454"
                     /note="AI2714v1_5454.mrna"
     CDS             6630..6929
                     /locus_tag="AI2714V1_5454"
                     /note="long variant; AI2714v1_5454.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="CAH3837281.1"
                     /translation="MPYDVEWKQGAIEDVTTLFDYIAENSSLWDAQNVTDRVLAAADKL
                     ADFPRLYEVDSRYGEDVRRISLMGQHVLYDVDDQTRKVRVLAVVGQRQNPHIVL"
                     /name="hypothetical protein"
     exon            6630..6929
                     /locus_tag="AI2714V1_5454"
                     /note="AI2714v1_5454.mrna"
                     /number=1
     gene            complement(6991..7368)
                     /locus_tag="AI2714V1_5455"
     mRNA            complement(6991..7368)
                     /locus_tag="AI2714V1_5455"
                     /note="AI2714v1_5455.mrna"
     CDS             complement(6991..7368)
                     /locus_tag="AI2714V1_5455"
                     /note="long variant; AI2714v1_5455.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="CAH3837380.1"
                     /translation="MAWVTVRQATELTGKARSSLYRDMAKGRVSYRTEADGGRVVDTSE
                     LIRVYGELRQDETHERDELRLSGETEKMASDALIAEIKALREEVAGLRQEMQSMRLLEH
                     KPETAETPAGTPRRWWPWGKR"
                     /name="hypothetical protein"
     exon            complement(6991..7368)
                     /locus_tag="AI2714V1_5455"
                     /note="AI2714v1_5455.mrna"
                     /number=1
     gene            7437..7616
                     /locus_tag="AI2714V1_5456"
     mRNA            7437..7616
                     /locus_tag="AI2714V1_5456"
                     /note="AI2714v1_5456.mrna"
     CDS             7437..7616
                     /locus_tag="AI2714V1_5456"
                     /note="long variant; AI2714v1_5456.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="Regulatory protein rop"
                     /protein_id="CAH3837390.1"
                     /translation="MTKQEKTALNMAKFIKEQSLLLLDKLNELDMDTPADMCERLHEDA
                     ETLWQVMRDKLGEE"
                     /name="Regulatory protein rop"
     exon            7437..7616
                     /locus_tag="AI2714V1_5456"
                     /note="AI2714v1_5456.mrna"
                     /number=1
     gene            complement(7644..8174)
                     /locus_tag="AI2714V1_5457"
     mRNA            complement(7644..8174)
                     /locus_tag="AI2714V1_5457"
                     /note="AI2714v1_5457.mrna"
     CDS             complement(7644..8174)
                     /locus_tag="AI2714V1_5457"
                     /note="long variant; AI2714v1_5457.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="CAH3837490.1"
                     /translation="MALYMVFIEDAEDRNGERCIMPTSEHLEDMVVLAWQTGAYVFCFV
                     DRAQHLAMMKSIGMYDERLNSDEKATYFFTGKNPQWERNKPTGMKLCDYLYRKVERFAI
                     ENGVQVVDAGKCSPEQINAMIDVVSERHGESAVNEKLKAELMREYNSRYFNVPVPELPE
                     DKPARRWWPFGKK"
                     /name="hypothetical protein"
     exon            complement(7644..8174)
                     /locus_tag="AI2714V1_5457"
                     /note="AI2714v1_5457.mrna"
                     /number=1
     gene            complement(8181..8912)
                     /locus_tag="AI2714V1_5458"
     mRNA            complement(8181..8912)
                     /locus_tag="AI2714V1_5458"
                     /note="AI2714v1_5458.mrna"
     CDS             complement(8181..8912)
                     /locus_tag="AI2714V1_5458"
                     /note="long variant; AI2714v1_5458.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="CAH3837585.1"
                     /translation="MALELYNVSHAKRQARNAEKTRLTLRWLREELCSTAELVARRLGI
                     AAVQPVYRFLDSLVAKGLLVRTKYPVDGRQVSVWGLTPHGVAFSFDEDEPLADVIPFQP
                     SRVSAAHLPHRLAVQSLRLDMEARGATGWRILHRLSLKGMKVPDALAELDGKTVAFEVE
                     RTVKSRRRYQEVVSGYLFNRKANGIDEIWYICPDRATQVRVQRAILSVDEIVNPQTGEA
                     RKTAELDRERLFACFKFMTTE"
                     /name="hypothetical protein"
     exon            complement(8181..8912)
                     /locus_tag="AI2714V1_5458"
                     /note="AI2714v1_5458.mrna"
                     /number=1
     gene            complement(8912..10876)
                     /locus_tag="AI2714V1_5459"
     mRNA            complement(8912..10876)
                     /locus_tag="AI2714V1_5459"
                     /note="AI2714v1_5459.mrna"
     CDS             complement(8912..10876)
                     /locus_tag="AI2714V1_5459"
                     /note="long variant; AI2714v1_5459.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="CAH3837686.1"
                     /translation="MFNTDSLAWKWHIPELARQIYPWVSWLYQEYYGLAGAFLVIGLFF
                     GLAELWAGRMRFVGLSHKERREYADRYKRDNKRPAPFSVLASLDSPGRMVRARRHVWNY
                     AYWLTGAAGLALLGGLVVAVFIESWGETVLRPDLYANADYYLLQPANLFGIAWCAGGLA
                     VGIVLARLLAFLLLDGHFAAADEAVNAKLNQESRRSSQRTGEMTDVRHLHFGEPVPVNA
                     LADFSSEQARQEQAVFLGKDEQGKPVLVPRDTWRKTNIQILGLPGSGKSVMATNALIRC
                     VRDFGDAVVYFDPKGDAWAPHVFRAHCPDFTLLDLRPGKPAQLNLFRDLDQYALKNLLI
                     AGLNLGETGDVADHYRISEQKAAKLIAEQFPQGANIQQVLAAAYALPEALKKDVKGLIT
                     RLENVADLSVLQTDSGIDVAGIINGGGCLYVIGSMDDEAVIRVQKMLFARCAQIIIARD
                     EFREWPHVSVMLDEIKYLLSKYVLNALGTLRSRDCNLLLAHQSLGDFGQCGQDLPAEFV
                     KTTVLDNTPIRWFYRAASLESAQWAAGQTGEIRVDVERRRASREAGNVEHISGDSFIQK
                     EARPLFDVNTLQHLPDGFAVMTGLGVARMAFSSPLRVERREIPLQRFPVLAKTDPLAEF
                     RPPADGGGPKADDDFAGIY"
                     /name="hypothetical protein"
     exon            complement(8912..10876)
                     /locus_tag="AI2714V1_5459"
                     /note="AI2714v1_5459.mrna"
                     /number=1
     gene            complement(11588..11716)
                     /locus_tag="AI2714V1_5460"
     mRNA            complement(11588..11716)
                     /locus_tag="AI2714V1_5460"
                     /note="AI2714v1_5460.mrna"
     CDS             complement(11588..11716)
                     /locus_tag="AI2714V1_5460"
                     /note="long variant; AI2714v1_5460.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="CAH3837785.1"
                     /translation="MEKRHLRGLAVLPHMLVPCLFTESVGNFACVRSARRSLTAGA"
                     /name="hypothetical protein"
     exon            complement(11588..11716)
                     /locus_tag="AI2714V1_5460"
                     /note="AI2714v1_5460.mrna"
                     /number=1
     gene            complement(12591..12848)
                     /locus_tag="AI2714V1_5461"
     mRNA            complement(12591..12848)
                     /locus_tag="AI2714V1_5461"
                     /note="AI2714v1_5461.mrna"
     CDS             complement(12591..12848)
                     /locus_tag="AI2714V1_5461"
                     /note="long variant; AI2714v1_5461.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="Colicin-E3 immunity protein"
                     /protein_id="CAH3837883.1"
                     /translation="MGLKLHIHWFDKKTEEFKGGEYSKDFGDDGSVIESLGMPLKDNIN
                     NGWFDVEKSWVSILQPHFKNVIDISKFDYFVSFVYRDGNW"
                     /name="Colicin-E3 immunity protein"
     exon            complement(12591..12848)
                     /locus_tag="AI2714V1_5461"
                     /note="AI2714v1_5461.mrna"
                     /number=1
     gene            complement(12858..>13394)
                     /locus_tag="AI2714V1_5462"
     mRNA            complement(12858..13394)
                     /locus_tag="AI2714V1_5462"
                     /note="AI2714v1_5462.mrna"
     CDS             complement(12858..>13394)
                     /locus_tag="AI2714V1_5462"
                     /note="short variant; AI2714v1_5462.mrna"
                     /codon_start=1
                     /transl_table=11
                     /product="Colicin-E3"
                     /protein_id="CAH3837981.1"
                     /translation="VTYNPPHEYGSGWQDQVRYLDKDIQNQNEKLKAAQTSLNEMNESL
                     SRDKAALSGAMESRKQKEKKAKDAENKLNEEKKKPRKGTKDYGHDYFPDPKTEDIKGLG
                     ELKEGKPKTPKQGGGGKRARWYGDKKRKIYEWDSQHGELEGYRASDGEHLGAFDPKTGK
                     QVKGPDPKRNIKKYL"
                     /name="Colicin-E3"
     exon            complement(12858..13394)
                     /locus_tag="AI2714V1_5462"
                     /note="AI2714v1_5462.mrna"
                     /number=1
     ARG             complement(1238..1788)
                     /name="aac(6')-Ib"
                     /gene="aac(6')-Ib"
                     /gene_name="AAC(6')-Ib family aminoglycoside
                     6'-N-acetyltransferase"
                     /tool="amrfinderplus"
                     /drug_class="AMINOGLYCOSIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             complement(896..1152)
                     /name="aadA15"
                     /gene="aadA15"
                     /gene_name="ANT(3'')"
                     /tool="rgi"
                     /drug_class="aminoglycoside antibiotic"
                     /identity="97.14"
                     /coverage="32.32"
     ARG             complement(1235..1839)
                     /name="AAC(6')-Ib10"
                     /gene="AAC(6')-Ib10"
                     /gene_name="AAC(6')"
                     /tool="rgi"
                     /drug_class="aminoglycoside antibiotic"
                     /identity="98.97"
                     /coverage="99.01"
     Typing          11676..12254
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="95.361"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(8185..8912)
                     /name="MOBC"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="1.34e-150"
ORIGIN
        1 ttcgttcatc catagttgcc tgactccccg tcgtgtagat aactacgata cgggagggct
       61 taccatctgg ccccagtgct gcaatgatac cgcgagaccc acgctcaccg gctccagatt
      121 tatcagggca ctgttgcaaa gttagcgatg aggcagcctt ttgtcttatt caaaggcctt
      181 acatttcaaa aactctgctt accaggcgca tttcgcccag gggatcacca taataaaatg
      241 ctgaggcctg gcctttgcgt agtgcacgca tcacctcaat acctttgatg gtggcgtaag
      301 ccgtcttcat ggatttaaat cccagcgtgg cgccgattat ccgtttcagt ttgccatgat
      361 cgcattcaat cacgttgttc cggtacttaa tctgtcggtg ttcaacgtca gacgggcacc
      421 ggccttcgcg tttgagcaga gcaagcgcgc gaccataggc gggcgcttta tccgtgttga
      481 tgaatcgcgg gatctgccac ttcttcacgt tgttgaggat tttacccaga aaccggtatg
      541 cagctttgct gttacgacgg gaggagagat aaaaatcgac agtgcggccc cggctgtcga
      601 cggcccggta cagatacgcc cagcggccat tgaccttcac gtaggtttca tccatgtgcc
      661 acgggcaaag atcggaaggg ttacgccagt accagcgcag ccgtttttcc atttcaggcg
      721 cataacgctg aacccagcgg taaatcgtgg agtgatcgac attcactccg cgttcagcca
      781 gcatctcctg cagctcacgg taactgatgc cgtatttgca gtaccagcgt acggcccacc
      841 gaatgatgtc acgctgaaaa tgccggcctt tgaatgggtt catgtgcagc tccatcagca
      901 aaaggggatg ataagtttat caccaccgac tatttgcaac agtgccgttt ccaaaaggtc
      961 gttgatcaaa gctcgccgcg ttgtttcatc aagccttacg gtcaccgtaa ccagcaaatc
     1021 aatatcactg tgtggcttca ggccgccatc cactgcggag ccgtacaaat gtacggccag
     1081 caacgtcggt tcgagatggc gctcgatgac gccaactacc tctgatagtt gagtcgatac
     1141 ttcggcgatc accgcttccc tcatgatgtt taacgtttga catgaggggc ggccaagggc
     1201 gccagccctt ggacgtcccc ctcgatggaa gggttaggca acactgcgtg ttcgctcgaa
     1261 tgcctggcgt gtttgaacca tgtacacggc tggaccatct ggggtggtta cggtaccttg
     1321 cctctcaaac cccgctttct cgtagcatcg gatcgctcgc aagttgctcg gcgacgggtc
     1381 cgtttggatc ttggtgacct cgggatcatt gaacagcaac tcaaccagag ctcgaaccag
     1441 cttggttccc aagcctttgc ccagttgtga tgcattcgcc agtaactggt ctattccgcg
     1501 tactcctgga tcggtttctt cttcccacca tccgtccccg cttccaagag caacgtacga
     1561 ctgggcatac ccaatcggct ctccattcag cattgcaatg tatggagtga cggactcttg
     1621 cgctaaaacg cttggcaagt actgttcctg tacgtcagca agtgtcgggc gtgcttcttc
     1681 tccgccccac cactcgacga tatgagatcg atttagccac tcatagagca tcgcaaggtc
     1741 atgctcagtc atgaggcgca gtgtgacgga atcgttgctg ttggtcacga tgctgtactt
     1801 tgtgatgcct aactttgttt ggaaatgttg aatactcata ctcttccttt ttcaatatta
     1861 ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat gtatttagaa
     1921 aaataaacaa ataggggttc cgcgcacttt tccccgaaaa gtgccacctg acgtctaaga
     1981 aaccattatt atcatgacat taacctataa aaataggcgt atcacgaggc cctttcgtct
     2041 tcaagaattt tataaaccgt ggagcgggca atactgagct gatgagcaat ttccgttgca
     2101 ccagtgccct tctgatgaag cgtcagcacg acgttcctgt ccacggtacg cctgcggcca
     2161 aatttgattc ctttcagctt tgcttcctgt cggccctcat tcgtgcgctc taggatcctc
     2221 cggcgttcag cctgtgccac agccgacagg atggtgacca ccatttgccc catatcaccg
     2281 tcggtactga tcccgtcgtc aataaaccga accgctacac cctgagcatc aaactctttt
     2341 atcagttgga tcatgtcggc ggtgtcgcgg ccaagacggt cgagcttctt caccagaatg
     2401 acatcacctt cctccacctt catcctcagc aaatccagcc cttcccgatc tgttgaactg
     2461 ccggatgcct tgtcggtaaa gatgcggtta gcttttaccc ctgcatcttt gagcgctctg
     2521 atctgaatat cgagggactg ctggctggtt gagacccgcg cataaccaaa aattcgcata
     2581 aaaatgtacc ttaaatcgaa tatcagacac gatgtgtcta ttatgccaaa atgacgattt
     2641 aatggacact caaacgaagc cgttttacta tgtctgataa tttataatat ttcgaacggt
     2701 tgcagttgtg ttaaaaaagc cgtcaggcag ggaggccgat atgcccgttg attttttgac
     2761 cactgagcag gttgagagtt atggcaggtt cactggcgaa cccgatgaac ttcagctggc
     2821 gcgttatttt catcttgatg aagcggataa agaatttatc gggaaaagcc ggggtgatca
     2881 caatcgactt ggtattgccc tgcaaatcgg gtgtgtgcgt tttctgggca cttttcttac
     2941 tgacatgaat catattcctt ccggcgtccg gcattttacc gccagacagc tcgggattcg
     3001 tgatatcacc gttcttgcag aatacggtca gagggaaaat acccgccgtg agcatgcagc
     3061 gctgatacgt cagcactatc agtatcgtga atttgcctgg ccctggacat ttcgccttac
     3121 ccgtctttta tatacccgga gctggataag caacgaacgt cctggcctgc ttttcgacct
     3181 ggcgacaggg tggcttatgc aacatcgtat tattctcccc ggagccacca cgctgacccg
     3241 gttgatttca gaggtaaggg aaaaggcgac gttgcgcctg tggaacaaac tggcactgat
     3301 accgtcagcc gaacagcgtt cacagctgga gatgctgctg gggccaactg attgcagccg
     3361 cctgtcttta ctggaatcac tgaaaaaagg ccctgtgacc atcagtggtc cggcgtttaa
     3421 tgaagcaatt gaacgctgga aaactctgaa cgattttggc ctgcatgctg aaaacctgag
     3481 tacactcccg gctgtgcgcc tgaaaaatct cgcacgttat gctggtatga cttcggtgtt
     3541 caatattgcc aggatgtcac cgcagaaaag gatggcggtt ctggttgcct ttgtccttgc
     3601 atgggaaacg ctggcgctgg atgatgcact ggacgttctg gacgccatgc tggccgttat
     3661 catccgtgac gccagaaaga ttgggcagaa aaaacggctc cgctcgctga aggatctgga
     3721 taaatctgca ttggcgctcg ccagcgcatg ttcgtacttg ctgaaagaag aaacaccgga
     3781 cgaatcgatt cgtgctgagg tgttcagcta catccctagg caaaagctgg ctgaaatcat
     3841 cacgcttgtc cgtgaaattg cccggccctc agacgataat tttcatgacg aaatggtgga
     3901 gcagtacggg cgcgttcgtc gtttcctgcc ccatctgctg aataccgtta aattttcatc
     3961 cgcacctgcc ggggttacca ctctgaatgc ctgtgactac ctcagccggg agttcagctc
     4021 acggcggcag ttttttgacg acgcaccaac ggaaatcatc agtcagtcat ggaaacggct
     4081 ggtgattaac aaggaaaaac atatcacccg aaggggatac acgctctgct ttctcagtaa
     4141 actgcaggat agtctgagac ggagggatgt ctacgttacc ggcagtaacc ggtggggaga
     4201 tcctcgtgca agattactac agggtgctga ctggcaggca aatcggatta aggtttatcg
     4261 ttctttgggg cacccgacag acccgcagga agcaataaaa tctctgggcc atcagcttga
     4321 tagtcgttac agacaggttg ctgcacgtct tggcgaaaat gaggctgtcg aactcgatgt
     4381 ttctggcccg aagccccggt tgacaatttc tcccctcgcc agtcttgatg agccggacag
     4441 tctgaaacga ctgagcaaaa tgatcagtga tctgctccct ccggtggatt taacggagtt
     4501 gctgctcgaa attaacgccc ataccggatt tgctgatgag tttttccatg ccagtgaagc
     4561 cagtgccaga gttgatgatc tgcccgtcag catcagcgcc gtgctgatgg ctgaagcctg
     4621 caatatcggt ctggaaccac tgatcagatc aaatgttcct gcactgaccc gacaccggct
     4681 gaactggaca aaagcgaact atctgcgggc tgaaactatc accagcgcta atgccagact
     4741 ggttgatttt caggcaacgc tgccactggc acagatatgg ggtggaggag aagtggcatc
     4801 tgcagatgga atgcgctttg ttacgccagt cagaacaatc aatgccggac cgaaccgcaa
     4861 atactttggt aataacagag ggatcacctg gtacaacttt gtgtccgatc agtattccgg
     4921 ctttcatggc atcgttatac cggggacgct gagggactct atctttgtgc tggaaggcct
     4981 tctggaacag gagaccgggc tgaatccaac cgaaattatg accgatacgg caggtgccag
     5041 cgatcttgtc tttggccttt tctggctgct gggataccag ttttctccac gcctggctga
     5101 tgccggtgct tcggttttct ggcgaatgga ccatgatgcc gactatggcg tgctgaatga
     5161 tattgccaga gggcaatcag atccccgaaa aatagtcctt cagtgggacg aaatgatccg
     5221 gaccgcaggc tccctgaagc tgggcaaagt acaggcctca gtgctggtcc gttcattgct
     5281 gaaaagtgaa cgtccctccg gactgactca ggcaatcatt gaagtggggc gcatcaacaa
     5341 aacgctgtat ctgcttaatt atattgatga tgaagattac cgccggcgca ttctgaccca
     5401 gcttaatcgg ggagaaagcc gtcatgcagt tgccagagcc atctgtcacg gtcaaaaagg
     5461 tgagataaga aaacgatata ccgacggtca ggaagatcag ttgggagctc tggggctggt
     5521 cactaacgcc gtcgtgttat ggaacactat ttatatgcag gcagctctgg atcatctccg
     5581 ggcgcagggt gaaacactga atgatgaaga tatcgcacgc ctctccccgc tttgccacgg
     5641 acatatcaat atgctcggcc attattcctt cacgctggca gaactggtga ccaaaggtca
     5701 tctgagacca ttaaaagagg cgtcagaggc agaaaacgtt gcttaacgtg agttttcgtt
     5761 ccactgagcg tcagacccct tttgatccca atttttccac ccagaaagct gacacaacac
     5821 gaatgatggt gccttttttc cggcagttct gggatatggg cgcaaaggat aaagcgaccg
     5881 gaaaatcacg gagtgatgtg cagcaacgca ttcagcagtt tcacagtcag gaatttttaa
     5941 actcactcca aggcacaaca caatttgcgg gtaccgatta ccgcagcaaa gacctcacac
     6001 cgaaaaaatc aaggctactg gctgacacca tttcagctgt ttatctcgat ggctatgaag
     6061 gcagacagta agtggattta ccataacgcg tcattacgcg caccgctcag acgggctcag
     6121 ggcgtttccg gcggctacgg gataaaacag gcaacaaccc ccccggaaaa ctgccggaaa
     6181 cgcgcccgat aaattttatc ctaatgcatg cctatgcacg caactgcatg gcatatgttt
     6241 tgacgtaaaa tggatgccgt aagccctttt ttaccgactt tctgcttcat cagcctgact
     6301 gacacgacca tattctttca gaccgccccc tgctaaactt ccttcatatt gccgcattaa
     6361 cccgggaggc tccgcaatga gcaacactac acactacgaa aacgccaact ttcttcggga
     6421 actggctgaa agcctgcccc gcatactgcc ggaaggtggc ccggacaaag ctgcgctgtt
     6481 gcagcgactg gctaacgaag aactggccca ggcagagtat gaagatcagg ttcgcgccaa
     6541 agtgaccgcc gcccgtgctg acacgcgtcc gggtatgacc acggaacaac tccgccagcg
     6601 cctgcatggc cgttatcagg aactgcgcga tgccgtatga cgtggaatgg aagcagggag
     6661 ccatcgagga tgtaacgacg ctgtttgact atatcgcgga aaattcatcc ctgtgggatg
     6721 cgcagaacgt taccgaccgg gttctcgctg cggcggacaa actggccgac ttcccgcgac
     6781 tctatgaagt ggactcacgc tatggcgagg acgttcgccg gatcagtctg atgggacagc
     6841 atgtcctcta tgatgttgat gaccagacca gaaaagtccg ggttctggcc gtggtcggcc
     6901 agcgccagaa tccccatatt gttctctaat aaccggtgac ggggacgcaa ttcattgcgt
     6961 ggccgtcgcc ggttggacaa gcacagcgcg tcagcgtttt ccccacggcc accaccggcg
     7021 cggtgttccg gccggggtct ctgctgtctc cggtttgtgt tccagcagtc tcatggactg
     7081 catttcctgc cgtagcccgg ccacctcctc cctgagtgct tttatctccg cgatcaacgc
     7141 gtcggaggcc attttttcag tctcacccga cagtctcaac tcgtcccgct cgtgagtctc
     7201 atcctgtctt aactcaccgt acacccggat aagctcgctg gtatccacca cccggccgcc
     7261 atcagcttcc gtacggtatg atacgcggcc tttcgccata tcccgataca gggaacttcg
     7321 ggctttaccc gtcagttccg tcgcctgtct caccgtcacc cacgccattg tctcaccccg
     7381 ctatttttga gacagtatac ctgacaggcg cacaccatgc ccggaaggaa agaatcatga
     7441 caaaacagga aaaaacagcc ctcaatatgg ctaaatttat taaggagcag tcgctgctat
     7501 tgctcgataa actgaatgag ctggatatgg ataccccggc cgacatgtgc gagcggctac
     7561 acgaggatgc ggaaacactc tggcaggtga tgcgggataa gctcggggag gaataacagc
     7621 accggcatgg ccggtgctgg catttatttt ttgccgaacg gccaccaccg gcgggcaggt
     7681 ttgtcctccg gcagttcagg taccggcacg ttaaaatagc ggctgttata ttcccgcatc
     7741 agctccgctt tcagcttctc gttcaccgcg ctttccccgt gccgctcact caccacgtca
     7801 atcatcgcgt taatctgctc cggtgagcac ttcccggcat caaccacctg cacaccgttc
     7861 tcgatggcga accgctccac cttgcgatag aggtaatcac acagcttcat tcctgtgggt
     7921 ttgttccgtt cccattgcgg atttttacca gtgaaaaagt acgtggcttt ttcgtcgctg
     7981 ttgagccgct cgtcatacat cccgatggat ttcatcatcg ccagatgctg ggcccggtcg
     8041 acaaaacaga aaacatacgc cccggtctgc caggcgagca ccaccatatc ttccagatgc
     8101 tcgctggtcg gcatgatgca gcgctcgccg ttccggtcct ccgcgtcttc aataaatacc
     8161 atgtacagcg ccataatccc tcactccgtt gtcataaatt taaagcacgc aaacaaccgt
     8221 tcacgatcca gctctgccgt tttgcgggcc tcgccggtct gtgggttcac gatttcatcc
     8281 accgacagga ttgcccgctg caccctgacc tgcgtcgccc ggtccgggca gatgtaccag
     8341 atttcatcga tgccgttagc tttgcggttg aacagatacc cggacaccac ttcctgatac
     8401 cggcgacggc tcttgacggt gcgctccacc tcaaacgcca ccgttttacc gtccagctcc
     8461 gccagggcgt ccggcacttt catgccttta agactcagac ggtgcagaat gcgccagccg
     8521 gtggcccctc tggcttccat atcaaggcgc agggattgca cggccagccg gtgcggcaga
     8581 tgtgctgccg acacccttga cggctgaaac ggaataacat ccgccagcgg ttcgtcctcg
     8641 tcgaacgaga acgccacgcc atgcggcgtc agcccccaca cgctgacctg acggccgtcc
     8701 accggatatt tggtccggac cagcagccct ttcgccacca ggctgtcgag gaagcggtag
     8761 accggctgca ccgccgcaat ccccagccgc cgcgcaacca gctccgccgt ggaacacagc
     8821 tcttcccgca accagcgcag ggtcagccgg gttttctccg cgttccgcgc ctgtcgtttc
     8881 gcgtggctga cgttgtacag ctccagcgcc atcagtaaat ccccgcaaaa tcatcatccg
     8941 ctttcggccc gccgccgtcg gccgggggcc ggaactccgc caggggatcg gttttcgcca
     9001 gcaccgggaa acgctgcaac gggatttccc ggcgctcaac ccgcagcgga ctgctgaacg
     9061 ccatccgggc cacacccagc ccggtcatga ccgcgaaccc gtccggcagg tgttgcaggg
     9121 tgttcacgtc aaacagcggc cgcgcctcct tctggatgaa gctgtccccg ctgatatgct
     9181 ccacgttccc cgcctcccgg ctggcacggc ggcgctccac gtccaccctg atttccccgg
     9241 tctgccccgc cgcccactgc gcggactcca ggctggccgc ccggtaaaac cagcggatcg
     9301 gcgtgttatc cagtaccgtg gttttcacaa attcagcggg cagatcctgc ccgcactgcc
     9361 cgaaatcgcc cagcgactgg tgcgcgagca acagattgca gtcccggctg cgcagcgtcc
     9421 ccagtgcgtt cagtacatac ttcgacagca gatatttaat ttcatcgagc atcacgctga
     9481 cgtgtggcca ctcccggaac tcgtcccgcg caatgatgat ttgcgcgcag cgggcaaaca
     9541 gcattttttg cacacggatc accgcctcgt cgtccatcga gccgataacg tacaggcagc
     9601 cgccgccgtt gataatcccc gccacatcga tgccactgtc cgtctgcagg acgctcaggt
     9661 cagcgacgtt ttccagccta gtgatcaacc ccttcacgtc ctttttcagg gcctccggca
     9721 gcgcgtacgc cgccgccagc acctgctgaa tgtttgcccc ctgcggaaac tgctccgcaa
     9781 tcagcttcgc cgctttctgc tcgctgatgc ggtagtggtc cgccacgtcg ccggtctcgc
     9841 ccaggttaag cccggcaatc agcaggtttt tcagcgcgta ctggtcgaga tcgcggaaca
     9901 gattcagctg cgccggtttc cccggccgca gatccagcag ggtgaagtcc ggacagtgcg
     9961 cccggaagac gtgcggcgcc catgcgtccc ctttggggtc gaagtacacc accgcgtccc
    10021 cgaaatcgcg tacgcagcga atgagcgcgt tggtggccat cacgctcttg ccgctcccgg
    10081 gcaggccgag gatctgaatg ttggtcttgc gccaggtatc acgcggaacc agcaccggct
    10141 tgccctgctc atccttaccc agaaacaccg cctgctcctg ccgggcctgc tccgaggaaa
    10201 aatcggccag cgcattaacc ggtaccggct ccccgaaatg caggtggcgc acgtcggtca
    10261 tctctcctgt ccgctggctg ctgcgccggc tctcctgatt cagtttcgcg ttcaccgcct
    10321 cgtcagcagc cgcaaaatga ccgtcaagca gcaggaacgc cagcagccgc gccaacacaa
    10381 tcccgacagc cagcccgccc gcgcaccagg caatcccgaa caggttagcc ggctgcagca
    10441 ggtaataatc tgcgtttgcg tagaggtccg gacgcaggac ggtttctccc cagctctcga
    10501 taaacacggc gacaaccagc ccccccagaa gggccagacc ggccgcgccg gtcagccagt
    10561 acgcgtagtt ccagacatgt cgacgtgccc tgaccatccg cccgggcgaa tccagcgagg
    10621 ccagcaccga aaatggcgct ggccgtttat tatcgcgctt atagcgatcg gcatactccc
    10681 gtcgctcctt atgactcagc cccacaaaac gcatccgtcc ggcccaaagt tcagccagac
    10741 cgaaaaacag gccgataact aggaaagccc cggccagacc gtaatactcc tggtacagcc
    10801 agctgaccca cggataaatc tgccgggcca gctccggaat gtgccacttc caggcaagcg
    10861 aatccgtatt aaacatgttc tctctccttc agacgatggt ttgccggcgt gatgtgcagc
    10921 ccccgctgca caagccgcgg acatgcccca aggcatggcg gcggcggtca cgtccgtggt
    10981 gattgcgttc agctttcacc acggaggcca gcctctttcc gccccatgcg gaaaaggcgc
    11041 agccccggag gaacaacgag cacgccccag cgtgtgagag gaaaaggcgg caccccagtg
    11101 cggtcttttc cggtgttccg gcccccgtca gagttcgcca tagcgagcgg ctgaccaccc
    11161 gcaaaatcag gagcagcttt gctgcttcgc caggtgcgtc cagcaccgtg gatttttgtg
    11221 ggtggtcagg cgtgagcctg acgggggccg ggtgaatttc tggcgtggcc ggcgtccagc
    11281 cggacggagc cagaaagagg gggagagacc gtgcgtcggt ggcgtccagc cagcgtaagc
    11341 aggggatatc cccctgaggt cagccacgcc ctcgcgggga tgacctgtat ttctccgtaa
    11401 ggagaaaaaa gcaacagaga taggttaacg taaaatgttc agcgaaaaac cgatatgatt
    11461 cacctatcct ggtaatttat tatcagggaa tataaagact taatcagggg acaatatgcc
    11521 acatcagcgc gtccggtgtc cgtcttgtag gtgccgggga aattgcgcct cctcgctcac
    11581 tcggtcgcta cgctccggcc gtgagactgc ggcgggcgct gcggacacat gcaaagttac
    11641 ccacagattc cgtgaataag caggggacta acatgtgagg caaaacggca aggccacgca
    11701 ggtggcgttt ttccataggc tccgccctcc tgactgagtt cacataaaca gacgcttttt
    11761 cggtgcatct gtgggagccg gtggctcaac catgaatcag tcaggagtgg cgaaacccga
    11821 caggacttaa agatcatcac cgtttccgat gaatcgctcc ctcttgcgct ctcctgttcc
    11881 aaccctgccg tttcccggat acctgttccg cctttctccc ttgcgggaag tgtggcgctt
    11941 tctcatagct cacactctgg tatctcggct cggtgtaggt cgttcgctcc aagctgggct
    12001 gtaagcaaga accccccgtt cagcccgact gctgcgcctt atccggtaac tgttcacttg
    12061 agtccaaccc ggaaaagcac gcaaaacgcc actggcagca gccattggta actgggagtt
    12121 cgcagaggat ttgtttagct aaacacgcgg ttgctcttga agtgtgcgcc aaagtccggc
    12181 tacactggaa ggacagattt ggttgctgtg ctctgcgaaa gccagttacc acggttaagc
    12241 agttccccaa ctgacttaac cttcgatcaa accacctccc caggtggttt tttcgtttac
    12301 agggcaaaag attacgcgca gaaaaaaagg atctcaagaa gatcctttga tcttttctac
    12361 tgaaccgcga tccccgtcag ttcagaggag gacgatggtg ccaccgttcc accctgaaca
    12421 tcccggatat agtttgcctg acatgcgacc agaagaaagc ctgaaaaaat caatataaaa
    12481 agaaaaacaa cctttacctt tttcatatac cttccctgta tttaaaaacc ccggtattca
    12541 tccctgaaca ccggaagtct gtatttcaaa tcatccttga taacttttgc ttaccagtta
    12601 ccatcccggt aaacaaagga tacaaagtaa tcaaatttac taatatcgat tacattttta
    12661 aagtgtggct gtaatatcga aacccatgat ttttcaacat caaaccaacc attattaata
    12721 ttatccttta aaggcatccc cagactttca atgacagaac catcatcacc gaagtctttt
    12781 gagtattcac cacctttaaa ctcttcggtt ttcttatcaa accaatgaat atgtaattta
    12841 agccccatat ttacctctta aagatatttt ttaatgtttc gttttggatc cggcccttta
    12901 acctgcttac ccgtttttgg atcgaatgcc ccgaggtgtt cgccatcact ggcgcggtac
    12961 ccttcaagct caccgtgctg ggaatcccat tcataaattt tacgcttttt atcaccatac
    13021 catcgggccc gcttaccacc accaccttgt ttaggggttt taggtttacc ctctttcaac
    13081 tctcccaacc ccttaatatc ttcagtcttg ggatcaggaa aataatcatg gccgtaatct
    13141 ttagttccct tacgaggttt tttcttttcc tcatttaatt tattttctgc atccttcgct
    13201 tttttctcct tttgtttccg gctctccatc gccccggaaa gcgcagcctt atccctggat
    13261 aaggattcat tcatttcgtt taaagatgtc tgggcagctt ttaatttctc attctgattc
    13321 tgaatatcct tatcaagata gcgaacctga tcctgccacc cggagccata ttcatgaggc
    13381 gggttataag tcacaaaatc atctttattt gcctctgcct cttttacctt tttatcggct
    13441 tcggggtctg acgctcagtg gaacgaaaac tcacgttaag ggattttggt catgagatta
    13501 tcaaaaagga tcttcaccta gatcctttta aattaaaaat gaagttttaa atcaatctaa
    13561 agtatatatg agtaaacttg gtctgacagt taccaatgct taatcagtga ggcacctatc
    13621 tcagcgatct gtctat
//
