LOCUS       NZ_OX291726            12879 bp    DNA     circular CON 03-SEP-2023
DEFINITION  Serratia marcescens strain SJC1058 plasmid 3, complete sequence.
ACCESSION   NZ_OX291726
VERSION     NZ_OX291726.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMEA13201026
            Assembly: GCF_946411905.1
KEYWORDS    RefSeq.
SOURCE      Serratia marcescens
  ORGANISM  Serratia marcescens
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Yersiniaceae; Serratia.
REFERENCE   1
  CONSRTM   Pathogen Informatics
  TITLE     Direct Submission
  JOURNAL   Submitted (11-AUG-2022) WELLCOME SANGER INSTITUTE, Pathogen
            Informatics, Wellcome Sanger Institute, CB10 1SA, United Kingdom
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 09/02/2023 08:08:11
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,389
            CDSs (total)                      :: 5,260
            Genes (coding)                    :: 5,180
            CDSs (with protein)               :: 5,180
            Genes (RNA)                       :: 129
            rRNAs                             :: 8, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 89
            ncRNAs                            :: 18
            Pseudo Genes (total)              :: 81
            CDSs (without protein)            :: 80
            Pseudo Genes (ambiguous residues) :: 0 of 81
            Pseudo Genes (frameshifted)       :: 32 of 81
            Pseudo Genes (incomplete)         :: 51 of 81
            Pseudo Genes (internal stop)      :: 13 of 81
            Pseudo Genes (multiple problems)  :: 12 of 81
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            OX291726.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..12879
                     /organism="Serratia marcescens"
                     /mol_type="genomic DNA"
                     /strain="SJC1058"
                     /serovar="NA"
                     /isolation_source="Bloodstream"
                     /db_xref="taxon:615"
                     /plasmid="3"
     gene            complement(join(12273..12879,1..50))
                     /locus_tag="N4J70_RS26800"
                     /old_locus_tag="SAMEA13201026_05347"
     CDS             complement(join(12273..12879,1..50))
                     /locus_tag="N4J70_RS26800"
                     /old_locus_tag="SAMEA13201026_05347"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_119879883.1"
                     /translation="MTEIKTECPDATWLRTTLAEMASDHFPVYDLPCLSVDPNSSAQLT
                     ALDDRRVAREMRQAAADVETRRIDAARVVEGLRTEAERLRGLIADGKTALRAGETVSPD
                     AGVAAFLLPDIEAELVAAEAAEADVARERDALLQDADRRDAAAAIGLFNLAHAVRVQRI
                     EQLLKLAMDEATLLAESDAGRSLYRTVINPDRRLNQLFSTQGAIEILRRNRGMEA"
                     /name="hypothetical protein"
     gene            310..897
                     /locus_tag="N4J70_RS26805"
                     /old_locus_tag="SAMEA13201026_05335"
     CDS             310..897
                     /locus_tag="N4J70_RS26805"
                     /old_locus_tag="SAMEA13201026_05335"
                     /inference="COORDINATES: protein motif:HMM:NF012464.3"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_181654175.1"
                     /translation="MSKTYGYVRVSTDEQTSNSQRDAIIARFPTASILADDGISGTVPP
                     RERPALGILLNQILQEGDTLVIYAIDRIGRNARDALELVEELEKRKVTLVSIREGVDLS
                     SAVGQAVLGIMASFAQMERKLILERQAAGIEAAKSRGQKFGRPTKIGAKEAGEIVMRRA
                     MGVPIATIAKQLNLSRSAIYRHLEKVDAVAPE"
                     /name="recombinase family protein"
     gene            1008..1193
                     /locus_tag="N4J70_RS26810"
                     /old_locus_tag="SAMEA13201026_05336"
     CDS             1008..1193
                     /locus_tag="N4J70_RS26810"
                     /old_locus_tag="SAMEA13201026_05336"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_119879885.1"
                     /translation="MINQAATPRYPGLSIEHGEIRQFGKPRHCAANRKGQYQTTLRDSA
                     GRYQTVSIISLYAWEA"
                     /name="hypothetical protein"
     gene            1312..1557
                     /locus_tag="N4J70_RS26815"
                     /old_locus_tag="SAMEA13201026_05337"
     CDS             1312..1557
                     /locus_tag="N4J70_RS26815"
                     /old_locus_tag="SAMEA13201026_05337"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_070558916.1"
                     /translation="MAFENIPRRFQRWKVIMVPGAKSYESWDEMVTGENFSEETRMKTY
                     KKHRTKAIDRTVANQEYIHTMTEDGITVRYRLERWR"
                     /name="hypothetical protein"
     gene            1756..2223
                     /locus_tag="N4J70_RS26820"
                     /old_locus_tag="SAMEA13201026_05338"
     CDS             1756..2223
                     /locus_tag="N4J70_RS26820"
                     /old_locus_tag="SAMEA13201026_05338"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008324036.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0004803 - transposase activity [Evidence IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="WP_070559148.1"
                     /translation="MKKYTTEQKAQALRLLEQDGATAATVARTMGIPPRTVRDWAKART
                     DAPSNVLSIEEMRERAQRAVEATPQAAIRRLKNHFVQRQFELLQRHATDLQALRTASLQ
                     AMLEKDATMVKAISGLMTSLLKTQERERVIYEIKPGTEADIMREGMNRQQS"
                     /name="transposase"
     gene            complement(2869..4164)
                     /locus_tag="N4J70_RS26825"
                     /old_locus_tag="SAMEA13201026_05339"
     CDS             complement(2869..4164)
                     /locus_tag="N4J70_RS26825"
                     /old_locus_tag="SAMEA13201026_05339"
                     /inference="COORDINATES: protein motif:HMM:NF017116.3"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VapE domain-containing protein"
                     /protein_id="WP_119879886.1"
                     /translation="MSQIDENSGTAADNVTPIAAAKVGRPSLQKKYPTTAFPVELEINY
                     RKGRYSSSLENVVAAMRCHSVTGIQLAFDEFFAEEGAFVNGQWYPLSDNLVTELRLRLA
                     AADFEKVTKDNARDAMFYVCDENKFDSAQRWLTAQEWDGKPRVSYFFERCFKCQGDPEY
                     LAAVSLYTWTALAGRVMNPGIKADMVPLLYGRQGARKSTGVRLMSPFPDSYSSFNLNDK
                     DDSLVRRMRGCLIGELEELRGLHGRDSESVKAFFSAAHDEWVPKFKEFKVRNPRRVVFI
                     GTTNNKQILNDSTGNRRYLPMNSGDVDCAAIEKNRSQLWAEALHLFNENGVMWEAAETL
                     ARKVHDEFRVEDPWEDEIAELLKLDVDDCDPTAFVPTKALFSQVGLMIGHTSNKQHQRM
                     AAIMSRLGYEVGRKRINGALVRGYFRRTQAVV"
                     /name="VapE domain-containing protein"
     gene            4692..5183
                     /locus_tag="N4J70_RS26830"
     CDS             4692..5183
                     /locus_tag="N4J70_RS26830"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008324040.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_070558888.1"
                     /translation="MREKTKTLTVRLPVSLIERIEQNAARTGATRTDAVIEALNAGLGT
                     KPEGMDTKLLAAIEALRAEVRALSVGGKPARQTAQQTAPQSAQQPARQIVPRGADPRFQ
                     AVSDEADQLIVSMTAENATLPAIASALNAAGHRTATGQEWNTSRVRDYRHKLRESGLLN
                     "
                     /name="hypothetical protein"
     gene            5248..5739
                     /locus_tag="N4J70_RS26835"
     CDS             5248..5739
                     /locus_tag="N4J70_RS26835"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_061351425.1"
                     /translation="MAIGDDAIRDAFYAFTQQAEEMDDKGLPQEVWETPCFTYLMTKKQ
                     FNQMKVVCQRNGWDIPASPAIPITWAMFRHVLSARNSKDKLSWQECAEILATAFSVQSN
                     VYVNRDYSEQTIVLNAVRRINVAGAGFFAMAIVDVSENNLAPVTAYHATEAKCKAIQRG
                     "
                     /name="hypothetical protein"
     gene            6186..6770
                     /locus_tag="N4J70_RS26840"
                     /old_locus_tag="SAMEA13201026_05341"
     CDS             6186..6770
                     /locus_tag="N4J70_RS26840"
                     /old_locus_tag="SAMEA13201026_05341"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004589499.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_061351424.1"
                     /translation="MDITISDATYSRLAAQAKGFETPEQVINRLIDVVEIDHDTRPELF
                     FNPEGEADFKKALLKSKQAKVEMFKRDGSCETGVWNARAISEESSVRANIWSGYLRGWK
                     EKGIVRAVFTVQEVPDLPGAAESVQWNDYTISRTFSGGISVQRNGMPVTIVKPFLRDVA
                     HDLKISLLNSNGNEMNTRQLGAAIIKKLNNS"
                     /name="hypothetical protein"
     gene            complement(7025..7483)
                     /locus_tag="N4J70_RS26845"
                     /old_locus_tag="SAMEA13201026_05342"
     CDS             complement(7025..7483)
                     /locus_tag="N4J70_RS26845"
                     /old_locus_tag="SAMEA13201026_05342"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_088765952.1"
                     /translation="MKSKTELREAATARSLAVIATEMSEWSLDGFSHLKLPNFSAGERQ
                     QTLSGSVVVDRPPFDYEWAGTEKFNTLATRALQVKLPASRERNYAWLCGVERETLATAL
                     LVELFSVTGCVAFAGLGKVADLAFLTLDESEAGQIRAAMLQWLDGAAA"
                     /name="hypothetical protein"
     gene            complement(7709..8890)
                     /locus_tag="N4J70_RS26850"
                     /old_locus_tag="SAMEA13201026_05343"
     CDS             complement(7709..8890)
                     /locus_tag="N4J70_RS26850"
                     /old_locus_tag="SAMEA13201026_05343"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_088765953.1"
                     /translation="MAFDNSHLTDAGLFWRAVSAAGAPVDREDWLRLCSGIACWASLCG
                     EDGLAAIEAWSTRHNRGSAHHRSQYRHFLKLKGVTNPEAMAQVFLRFSGEVYWRLDSNR
                     TPPSTEQVAALAERKRRSIEAVARREDADRRKADKAAADAVRMLAKGDGNPAYTPYWRN
                     KTTIARRGGVSLPPLPADLRVGGLFRSFEPRAYWSRCLLVPAYRLTDDRQLVGDALEAI
                     CGVCSAGGKTGDKFSPAGTQKAGRFYPMPGFMDVLDTSPHAPYSPLFVCEGFATAVALH
                     HLTKGKVAVCAAFSIAGFGSCVASLRRFWPDVDVMLVPDHGEAYRLAHKAAYGDEREPV
                     PTIPGAAVVSFDGLDRFTPRDNLDWFDVLVEEGEDRARELLRYAVRHARLERR"
                     /name="hypothetical protein"
     gene            complement(8877..9086)
                     /locus_tag="N4J70_RS26855"
     CDS             complement(8877..9086)
                     /locus_tag="N4J70_RS26855"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_088765954.1"
                     /translation="MKKRIYTADLAALLNVSLRTLSRLSSRGIVPTPAGRSLRGGHYWL
                     AGDPVLKRFIADQRRPGRAPYGVR"
                     /name="hypothetical protein"
     gene            9442..10731
                     /locus_tag="N4J70_RS26860"
                     /old_locus_tag="SAMEA13201026_05344"
     CDS             9442..10731
                     /locus_tag="N4J70_RS26860"
                     /old_locus_tag="SAMEA13201026_05344"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_157698538.1"
                     /translation="MNDDNDTTEATQPSTEALKCVGAAERFPDIMPGVLFVTCPGGCSL
                     RVEACRQIYEQSHLDRTIENPHLECHRCPTGLALWVGTEQPPDAPLTTPADTRKLCPRC
                     SRKDNRLIAPNKPGSSLCVSCWNREREATIGANARGRVNRTPPFVSPFLIGIGDGWQVW
                     YGIHQGEALVRAMRANPGARFHDRRPGPVGQTRRDGFVYYCPEHREPLRWNGGDGHAGE
                     VELACPRCQPWAAPLSVAPTFQTVSFQTPHDAAHQYRNATLPDNAVWTSSVCADCKAAP
                     LVISKAPVKGKPRREIVVSCPSCDSSASARPGGRTWTDEHIAVPEFAQNETRSLAKIPV
                     ILPQGEQPQLLKRPGTGRGPGRPRKRIPLTLDRVPESRFNRLALSVLAAVGRWDYINDI
                     IRRIDRNRGDAATLIALADHIRTNRPERDL"
                     /name="hypothetical protein"
     gene            10728..11369
                     /locus_tag="N4J70_RS26865"
                     /old_locus_tag="SAMEA13201026_05345"
     CDS             10728..11369
                     /locus_tag="N4J70_RS26865"
                     /old_locus_tag="SAMEA13201026_05345"
                     /inference="COORDINATES: protein motif:HMM:NF016255.3"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ProQ/FINO family protein"
                     /protein_id="WP_070559060.1"
                     /translation="MTETTRPILTIKRRNRTVYVPPEKAAKSEPQPAERTTSKAKVQPK
                     AKAPQKPAQKPTAAKPKKTPEQVAEGIRRQEENDRRQQDIAIANKSKKALANRVTKAFL
                     KEHWPDLLTRGVDRRPMAKGIIEQILTRGAELNMPPEADRKAVRRILGIVTGTSSYQQS
                     LIDQCMRYDLDGNPTEPATPEEAENAKARLTEIKAFRRKARQAKGEKKGA"
                     /name="ProQ/FINO family protein"
     gene            complement(11527..11883)
                     /locus_tag="N4J70_RS26870"
     CDS             complement(11527..11883)
                     /locus_tag="N4J70_RS26870"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_070559062.1"
                     /translation="MPRHLQGKTRMPLAGGCYSAGHRLALISLLPVLEARPGDRDDGER
                     SKLALYQESLIKAGQPHAFALHEPSLYRWGAYLKSRRARYLQETDAGVAAASDALDRHA
                     FGRAIGAVLGADDE"
                     /name="hypothetical protein"
     gene            complement(11889..12272)
                     /locus_tag="N4J70_RS26875"
                     /old_locus_tag="SAMEA13201026_05346"
     CDS             complement(11889..12272)
                     /locus_tag="N4J70_RS26875"
                     /old_locus_tag="SAMEA13201026_05346"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_070559064.1"
                     /translation="MSAFSMLCDRLRHEATLAKSTGAGDALAQVLETGGAAQTFAPIGA
                     PVASPTESVHRARAQSIQDAAFLTEMKQAGVAPADLVMLDGVLASSRGLPDASRAPAFA
                     AVRAQVQQQASLSPAARGINWDE"
                     /name="hypothetical protein"
ORIGIN
        1 gtggtacgca gccaggtcgc gtccgggcat tcggttttga tttcggtcat ggtttggttc
       61 tcagcaagtt atcagcaaag cggcagcaaa cgccgctcag acagcatgcc gtcacgacac
      121 cgcgcagaca tcaacgcaga gggcgcaggg ctctcgccca gcgcggagag ccgcctggag
      181 gccgtcgcta atcccctaca ttccgggaca cccgacaaag cgacgaaata gacactttag
      241 cgatagactt tcggtacagt tgtggcatgt tgtgtcgaaa gagacgtatc ggtcagagga
      301 gagaaaaaag tgagcaaaac atacggttac gttcgcgtat caaccgacga acaaaccagc
      361 aacagccagc gcgacgccat catcgcccgg ttcccaacag cctccatcct cgccgacgac
      421 gggatcagcg ggacggtacc accacgcgag cgtccagccc tcggcatcct cctgaaccag
      481 atcctgcagg agggcgacac gctggtcatc tacgcgatcg accgcatcgg caggaacgcc
      541 cgggacgccc tcgaactggt cgaggagctg gagaaacgaa aagtaaccct ggtcagcatc
      601 cgcgagggtg tcgatttgag cagcgccgtc ggacaggccg tcctcggcat catggcgagt
      661 ttcgcgcaga tggagcgcaa gctcatactg gaacgccagg cggcagggat cgaggccgca
      721 aagagccgtg gccagaagtt cggacgcccg accaagatcg gcgcgaaaga agcgggggag
      781 atagtcatgc gccgcgccat gggggtacca atagccacca tagccaagca gttaaatctg
      841 agcaggagcg cgatttaccg ccaccttgag aaggtcgacg cggtagcgcc ggagtaagag
      901 agagcgcagc ggtgtaggtg gctccaacca ttccacaccg ccgcaaccca gcccggggaa
      961 cgcatgagga gcagacccgg gcaccattcc caacaaggaa cagaaccatg ataaaccaag
     1021 cagcaacacc gcgctatccc ggcctgagca ttgaacacgg cgagatccgc cagttcggca
     1081 agccccgcca ttgcgccgcc aaccgcaaag gccagtacca gaccaccctc cgcgacagcg
     1141 ccggtcggta ccagacagtc agcatcatca gcctttacgc ctgggaagca tgaccataac
     1201 gaaagcctta caggtgtaag cagcaagcaa taacaaaagc cttacgccat tacgaaccac
     1261 ttacaggggc gcgggagcgc ccccagaaac cagaatcata aggagagaac gatggcattt
     1321 gaaaacattc cccgtaggtt ccagagatgg aaggtaatca tggttcccgg agcaaagtca
     1381 tatgagtcat gggacgagat ggttaccggc gagaacttct ccgaagaaac caggatgaaa
     1441 acgtacaaaa agcaccgcac caaggccatc gaccgcaccg tggcaaacca ggagtacatc
     1501 cataccatga cggaggacgg gatcaccgtc aggtaccgcc tcgaacgctg gcgctaaccc
     1561 cagctaggag cgcagcgact gctgcgcctc ctcccttacc cagaacgcac cagagccatt
     1621 ctaagcgcct cagccacaaa aatacccaac cgcacgacca cgcacgcaca aacgccgtgt
     1681 accccccaaa aacccccgcc attttcagcg cgtgacgttt caatacagga gagaaaccaa
     1741 ccggagcagg acaccatgaa gaaatacacc accgagcaga aagcccaggc gctcagacta
     1801 ctggagcagg acggcgcaac cgcagccacc gtcgcacgca ccatggggat cccaccccgc
     1861 accgtcagag attgggcgaa agcccgcacc gacgcaccca gcaacgtcct cagcatcgag
     1921 gagatgcgcg aacgcgcaca gcgagccgtc gaggccaccc cacaggcagc gatccgacgc
     1981 ctaaaaaacc actttgtaca gcgccagttt gagctgctac agcgccacgc caccgacctg
     2041 caagccctcc gcacagcttc gctacaggcc atgctggaga aggacgccac catggtcaaa
     2101 gcgatcagcg gccttatgac atccctactc aagacgcagg aacgcgagcg cgtcatctac
     2161 gagatcaagc caggcaccga ggccgacatc atgcgcgagg gcatgaatcg ccaacagagc
     2221 tgaaaacggc gggaaaaccg ccttttaccg ccgctttacc gccgcagaaa acccgggagc
     2281 ccgcgaaata cgcggatccg cacgttaacg agttgttacc gctcgcgtgc gcgagggcaa
     2341 gccctcacgc agaaccaaca gacgaccacc cagcgcgagg cgaaagcctc gtgccctcag
     2401 cgccacccaa acctccgatc cccctcagaa ccactaccac cgaccatccc ggcacgacga
     2461 acccatccac cgatctaata agacaagcaa agtgcatccg gcagggtgca gctgcggcgc
     2521 gtcgattcca agatgatcca cccgttccac ccgatccggc atagattcat aaatagtaaa
     2581 aaaaacaact aattgttcaa ttagtgagca tttaccccct atttacccaa tttattcatt
     2641 ttttgttttt aattagaaaa tagggtggaa cgggtggaac acaacaatga aagcctttaa
     2701 acacgaggcc ttagctgttc catccacggg cggaacacgg gtggaacggg tggaacaccc
     2761 gggtggaaca ggtggtacaa aaacggcgtg atgatccacc cgtgatccac ccgggtggaa
     2821 caataaaaaa ggggagcata tagctcccct cttacggaaa agtaaccctt acacgacagc
     2881 ttgcgttcga cggaagtagc cacgaactaa cgcaccgttt atgcgcttcc tgccaacctc
     2941 atagcccaat cgggacatga tagccgccat gcgctgatgc tgcttgttgc tggtatggcc
     3001 aatcatgagc cctacctgag agaacaaggc cttcgtcggc acgaaagcag tcgggtcgca
     3061 gtcgtcaacg tccagcttga gcagctcggc gatctcgtct tcccacggat cctcgacgcg
     3121 gaactcgtca tgcaccttac gcgccagcgt ttcagcggcc tcccacatca ccccattctc
     3181 attgaacagg tggagcgctt cagcccacag ctgcgagcgg tttttctcga tggccgcgca
     3241 gtccacgtcc ccggaattca tgggcaaata gcggcggttc cccgtcgagt cattgaggat
     3301 ctgcttgttg ttcgtggtac cgatgaacac cacgcggcgc gggtttcgca ccttgaactc
     3361 tttaaatttc ggcacccact cgtcgtgggc agcggagaag aacgctttca ccgattcgga
     3421 gtcgcgcccg tggaggccgc gcagctcctc cagctcgcca atcaggcacc cacgcatacg
     3481 gcgcactagg gagtcgtcct tgtcgttcag gttgaagctg gagtaggagt cagggaatgg
     3541 cgacataagg cgaacgcccg tcgatttgcg ggcaccctgt cgcccgtaca gcagcggaac
     3601 catgtcggcc ttgattccgg gattcattac gcgcccggca agcgccgtcc aggtgtagag
     3661 gctgaccgcc gccaggtact cgggatcccc ttggcatttg aagcaccgct cgaagaagta
     3721 actgacgcga ggtttgccgt cccattcctg agccgtcagc caacgctggg cgctgtcgaa
     3781 tttgttctca tcgcagacgt agaacatggc gtcgcgggca ttgtccttgg tcaccttctc
     3841 gaagtcggca gcagcgaggc gcagacgcag ctcggtaact aggttgtcgg acagcgggta
     3901 ccattgcccg ttcacgaacg ccccctcctc cgcaaagaac tcatcgaaag cgagctggat
     3961 gccggtgacg gaatggcagc gcatagcggc gacaacgttc tcaagagagg acgagtagcg
     4021 ccccttccgg tagttgatct ccagctccac gggaaacgcg gtagtcgggt attttttttg
     4081 tagagacggg cgtcccacct tggcagcggc gatcggcgtt acgttgtcgg cagcagtgcc
     4141 ggaattttca tcaatttgtg acacgcaatt actcctttaa aaacgtagga gtcggcgtca
     4201 ggcgggggct tacgagggaa attcacactt gcgcgatctt atcgacgtgg tacacttctc
     4261 tttgagtttg aggagtacgc tgcgcaagtg ctattcttcc ttcgagaacg tcccgctaag
     4321 acgtgactcg aattaatcgg aggagttacc agctcccccg gcagaaaaag gtgaccaccc
     4381 aacaggtcgc ctttttttgt gcccgaagat ccccaaccgg atccgcagac gccagatcag
     4441 cttacccgat cccaaccctc cacgccactt agcgccgcgc acttatcgcg ctgtcgtgat
     4501 cacgcccagc tcaatctctg cgccgcctct gctatttatc catgtacaca aacggcaccc
     4561 cggcgacgca aagccgtcgc ccctctgtgc acgacaactg cacgacgtcg aattcgacgc
     4621 gcacgacaaa acgcattaca ctacgcaaga caaacagcac gacaaaacgc acgacgtgga
     4681 gagcagcagc catgagagag aaaaccaaaa ccctgaccgt tcgcctaccc gttagcctga
     4741 tcgaacgcat cgagcagaac gcagcacgaa ccggagcaac ccgcacggat gctgtcatag
     4801 aggcgctgaa cgccggactt ggcacgaagc cggaagggat ggacaccaaa cttttagctg
     4861 ccatcgaagc gctgagggct gaagtcaggg cgctgtccgt cggcggtaaa cctgcacgac
     4921 aaaccgcaca acaaacagca ccacaaagcg cacaacaacc tgcaagacag atagtccccc
     4981 ggggagccga tccgcgcttc caggccgtca gtgatgaggc tgaccagctc attgtcagca
     5041 tgaccgcaga gaacgcgact ctgcccgcca tcgcgtcggc actgaacgca gcagggcacc
     5101 ggacagcgac gggacaggag tggaacacca gccgtgtccg ggactatcgc cataagttgc
     5161 gggaaagtgg gctactgaat tagcagtcct aagtgacata gctaaatatg ataaaattcg
     5221 aacataaaaa ttttacaagg aaaagaagtg gctatcggtg atgatgctat ccgtgacgct
     5281 ttctatgctt ttacacagca agctgaagaa atggatgata aaggtctccc tcaggaagtt
     5341 tgggagacgc cttgttttac ctatctgatg actaagaagc agttcaatca aatgaaagtt
     5401 gtttgtcaga gaaacggctg ggacatacct gcatcaccag caataccgat cacttgggca
     5461 atgtttaggc atgtgctatc tgctcgtaac tcgaaggata agctaagttg gcaagagtgt
     5521 gcggagattt tggcaactgc attctcagtg cagagcaatg tgtacgttaa cagagattac
     5581 tcggagcaga ctattgtgct caatgctgtt cgtcgcatta acgttgctgg ggctggcttt
     5641 ttcgcaatgg cgatagttga tgtctctgaa aataatttgg cccccgtgac tgcataccat
     5701 gcaacggagg ccaaatgtaa agctatacag cgagggtgat aggaaggacg cccatttaag
     5761 caattctcct caatttaatg agaatgaacc ataacgccta aatatttccc ttcattggtt
     5821 cctttcggat ctagcagcat cggcggtttt ctgctgtcta tcaaattcac tgttattact
     5881 aggaagccgc aacataactt cccaacagga gaccagcctc ctgactgccc agcgcaaagg
     5941 gttaattact ggttaatacc ccctgcgaat gctcttgcag tacaacaata gtaggctatt
     6001 gttgacgtag attcaactgg tttgtttata accaagcggc acgaggagcg ggtttacagg
     6061 tttttatagc tctttagagg cggttaacca tattgcgata tcaggtaatt atagatcttg
     6121 aaatcattaa atttatcaat tatgattaat tttatgatta atttttgatc tatagaggta
     6181 ctttgatgga tattacgata tctgacgcta catatagccg tcttgctgca caagcaaagg
     6241 gatttgaaac tcccgaacag gtaataaacc gtctgatcga tgttgttgaa atcgatcatg
     6301 acacacgccc tgaacttttt tttaatcctg aaggtgaagc ggattttaaa aaagcgttac
     6361 taaaatcaaa acaggccaaa gtcgaaatgt ttaaaaggga tggttcctgt gaaactggag
     6421 tatggaatgc tcgtgcgatt tcagaagaat catcagttcg ggcaaatatt tggagtgggt
     6481 atttgcgtgg atggaaggaa aaagggattg ttcgtgcggt tttcactgtc caggaggttc
     6541 ctgacttgcc aggagcggct gaaagtgtgc agtggaatga ttatacaatc agtcgcactt
     6601 ttagtggcgg tatttcagtt caaagaaatg gcatgcctgt aactattgtg aagccatttc
     6661 tacgtgatgt tgcgcatgat ttaaaaatat cattgctaaa tagcaatgga aatgaaatga
     6721 atactcggca gcttggcgca gcgatcataa agaagttaaa taactcttaa catcgatgct
     6781 tcacgcagag gagcgacggc tcaacgccgc cgccggtcag agttctactg cgacgaatac
     6841 gcaccattca tagctggcga ggcagaacgc ccgccacctg tcatcagacg cccggtcaac
     6901 acactccagc cataaccgcg ccgcagcaag gtggtcgcag cgcaccgggt cgccccgcag
     6961 ttccgtcgcc atggcctcct cgatcagtcg cccttcccac tccagctgat cgaggatcga
     7021 gcccctacgc cgccgcccca tcgagccact gcagcatcgc cgccctgatc tgccccgcct
     7081 cgctctcgtc cagcgtcagg aacgccagat cggcaacctt acccagcccg gcgaacgcca
     7141 cgcagccggt gacggagaac agctccacga ggagcgccgt cgccagcgtc tcccgttcaa
     7201 cgccgcacaa ccaggcgtag ttacgctcac gcgatgccgg aagtttcacc tgcagcgcac
     7261 gggtggccag agtgttaaat ttctcggtac cagcccactc gtagtcgaac ggcgggcgat
     7321 caaccaccac cgacccggac agcgtctgct ggcgttcccc agcggagaag ttcggcagct
     7381 tgaggtggga gaacccatcg agcgaccact ccgacatttc agtggcgatc accgccagag
     7441 agcgagccgt cgcggcctcg cgtagttcag tctttgattt catgtgccct cctttgggct
     7501 aaaaaaaaac ccgacatcaa gacgaggccg ggctttatgc tgctgtgaga aaccgatcgc
     7561 aggatagcgt cacgacggca gcgccggtgc gtcgctttag tccgtctcat caaaaaagca
     7621 tcggtagtgt ctcgaaagtc gttcgctaaa ccagacgcca cgacggcaaa aaagatgtcc
     7681 cgaaaggcgc accattcgga cacgccaatc aacgccgctc aagccgggca tgacgaaccg
     7741 cgtagcgcag cagctcacga gcccgatctt ccccttcctc aaccagcacg tcgaaccagt
     7801 cgaggttatc ccggggcgtg aagcgatcga ggccgtcgaa cgacacaacc gccgcgcctg
     7861 gaattgtcgg gaccggctct cgctcatcgc cataggccgc tttatgcgcc aggcggtacg
     7921 cttcgccgtg atccggtacc agcatcacat caacatctgg ccagaaccgg cgcagcgacg
     7981 ccacgcagct gccgaacccg gcaattgaga acgccgcgca gactgccacc ttgcccttcg
     8041 tcagatgatg cagggcaacc gccgtggcga acccctcaca gacgaacaga ggcgagtagg
     8101 gcgcatgtgg tgaggtatcg agcacgtcca taaagccggg catcggatag aaccgtcccg
     8161 ccttttgggt acctgcaggg gagaacttgt cgccggtttt gccgccagca gagcagacgc
     8221 cgcagatggc ctccagcgcg tcgccaacca gctggcgatc atcggtcagg cgataggcag
     8281 gaacaagcag acagcgcgac cagtacgccc tcggttcgaa cgagcggaac aagccaccca
     8341 cacgaaggtc agcggggagg ggcgggaggc tgacgccacc acgcctggcg attgtggtct
     8401 tattgcgcca gtacggggta taggccggat taccgtcgcc tttcgccagc atcctgaccg
     8461 catcagccgc agccttatcg gccttgcgcc ggtcggcatc ttcgcgtctg gccaccgcct
     8521 cgatcgatcg gcgtttccgt tcagcaagag cagcaacctg ttcagtcgac ggcggcgtgc
     8581 gatttgagtc gagccgccag tacacctcgc ctgagaaccg caggaatact tgcgccatgg
     8641 cctcgggatt ggttacgcct ttcagcttca ggaagtgccg gtactgcgac cggtgatgcg
     8701 cagatccgcg attgtggcgg gtagaccagg cctcgatagc agcaagcccg tcctctccgc
     8761 agagagatgc ccagcatgcg atgccagaac agaggcgcag ccagtcctcg cggtcaaccg
     8821 gagccccagc cgcagagacg gcacgccaga acaggccagc gtcagtcagg tgagagttat
     8881 cgaacgccat aaggagccct cccgggacga cgctggtcgg caataaagcg tttgagcacg
     8941 ggatccccag ccagccagta atgcccgcca cgaagggaac gccctgccgg agtcggaacg
     9001 atcccccgcg aactcaggcg ggagagcgtg cgcagcgaca cgttcagcag cgcagcgagg
     9061 tcagcggtat agattcgttt tttcattggg agtaccagat aggtgccccc ctcagcttaa
     9121 cgggcatcgg ggggcgggag tgacgattat cgataaagcc gcccttgagg acttaccgca
     9181 tagcggcagg acagcagccc ttctcgctta ctcgcacctg ccaaggacga agcgcgcatc
     9241 ctcgtttaca accccgcctc gttggggagg agggaaagcg gcaccgggcg atccggtttc
     9301 atgtttccca actgctcgtc aggaatcagt aagacaagct taacacaatt aacgccaaag
     9361 tggcgttttt tgtgagatac taaaaaagac gcacagccag tgctggcgag gtctggcgac
     9421 catttcgacg cagggggagc agtgaacgac gataacgaca cgacagaagc gacgcagccg
     9481 tcaaccgagg cactgaagtg cgtaggcgct gcggagcggt tccccgacat catgcccggc
     9541 gttttgttcg tcacctgccc cggcgggtgc tccctccggg tcgaggcatg ccgacagatt
     9601 tatgagcaga gccacctcga tcgcacgatt gaaaaccccc acctcgagtg ccaccggtgc
     9661 cccactggcc tcgcgctttg ggtcggtacc gaacagcccc ctgacgcacc actgaccacc
     9721 ccggcagaca cccgtaagct ctgcccccgt tgcagccgga aagacaaccg cctgatcgcc
     9781 cccaataagc ccggttcgag cctgtgcgtc tcctgctgga accgcgaacg cgaagccacc
     9841 atcggagcca acgcacgcgg gagagtcaac cgcaccccac cgttcgtctc gccgttcctg
     9901 atcggcatcg gcgatggctg gcaggtctgg tacggcatcc accagggcga ggcgctcgtc
     9961 cgcgccatgc gagccaaccc gggcgcacgg ttccacgatc gccgaccagg cccggtcggg
    10021 caaacacgcc gcgacggttt cgtgtactac tgccccgaac accgcgagcc cctgcgctgg
    10081 aacggtggcg acgggcacgc cggagaggtg gagcttgctt gtcccaggtg ccagccatgg
    10141 gcggcacctc tcagcgtcgc ccccacgttt cagacggtca gcttccagac accgcatgac
    10201 gccgcgcacc agtaccggaa cgccaccctg ccagacaacg cggtctggac atcgtcggtc
    10261 tgcgctgatt gcaaagccgc gcccctggtg atcagcaagg caccggtcaa gggcaagccg
    10321 cgacgggaga tcgtcgtctc ctgcccgtcc tgcgactcca gcgcatcagc caggcccgga
    10381 ggcaggacat ggacagacga gcacatcgcg gtgcccgagt tcgcgcagaa cgagacgcgc
    10441 agcctggcga agatccccgt tattttgccg cagggggagc agccgcagct gctcaaaaga
    10501 ccagggacag ggcgcggtcc aggacgcccc cgcaagcgca tccccctgac cctcgaccgg
    10561 gtaccagaga gccggttcaa ccgcctcgcc ctttccgtcc ttgccgccgt cgggcgctgg
    10621 gactacatca acgacatcat ccggcgcatc gatcggaacc gcggcgacgc cgccaccctg
    10681 atcgcccttg ccgaccacat ccggaccaac cgaccagaga gagatttatg accgaaacca
    10741 cccgtccgat cctgaccatc aagcgacgca accgcacggt ctacgtcccg ccggaaaagg
    10801 ccgcgaaatc tgagccgcag ccagccgaac ggactaccag caaggcgaag gtacagccaa
    10861 aagcgaaagc cccgcagaag cccgcacaga agcccacagc ggcaaagccg aaaaagacgc
    10921 ctgaacaggt cgccgagggg atccgcagac aggaggagaa cgaccgccgc cagcaggaca
    10981 tcgcgatcgc caacaagtcc aaaaaggcgc tggccaaccg ggtgaccaaa gcattcctga
    11041 aagagcactg gcctgacttg ctgacccggg gagttgaccg tcgccccatg gcaaagggca
    11101 tcatcgagca gatcctgacc cgaggcgcag agctgaacat gccgccagag gcagaccgca
    11161 aagccgtccg tcgcatcctg ggcattgtca cgggtacgag ctcgtaccag cagagcctca
    11221 tcgaccagtg catgcgctac gacctggacg gcaaccccac cgaaccagca accccggagg
    11281 aggccgaaaa cgccaaagcc cgcctgacag agatcaaggc attccggcgc aaggcacgcc
    11341 aggcgaaggg cgaaaaaaag ggcgcataac gcgccccgtc tcacccagca ccatgtaggc
    11401 gcagcacgac gttcagcagc acggcgagca gctgcgacac gttgcgcgat ccccctggcc
    11461 tttcgcgcag caacaacccc gtcagggatc accacctcag ggatgaccag acgcgagacg
    11521 gcaaactcac tcatcatcag cccccaggac cgcaccaata gcacgcccga aagcatgccg
    11581 atcaagcgcg tctgaggccg cagcaacacc tgcgtctgtc tcctgtaaat accgggcgcg
    11641 gcggctcttc agatacgccc cccagcgata cagcgacggc tcatgtaacg cgaacgcgtg
    11701 cggttgcccg gccttgatca gcgattcctg atacagcgcc agcttcgatc gttcaccatc
    11761 atccctgtca ccaggacgag cctccagaac aggcagcaac gagatcagcg caagacggtg
    11821 gccagcagag taacaaccac ctgccagcgg catccgcgtc ttaccctgca ggtggcgcgg
    11881 catcggcttt actcgtccca attgataccc cgggcagcag gggagagaga cgcctgttgc
    11941 tgcacctgag cacgcaccgc agcgaacgcc ggagcacgcg acgcatcagg gagtccgcga
    12001 gaggaggcca gcacgccgtc aagcatcacc agatcggcag gagccacgcc cgcctgtttc
    12061 atctcagtca ggaacgccgc atcctggatg gactgagcac gcgcccggtg aaccgactcc
    12121 gtaggagagg caaccggagc cccgatcggc gcgaacgtct gcgcagcacc gcccgtctcc
    12181 agcacctgcg ccagcgcgtc gccggccccg gtagattttg ccagcgtcgc ctcatggcga
    12241 agccggtcac acagcatcga aaatgcagac atttacgcct ccatgccgcg attgcggcgc
    12301 agaatttcga tcgcaccctg cgtggagaac agctggttca ggcggcgatc aggattgata
    12361 acagtacggt acaaactgcg ccccgcgtcg gactcggcaa gcagcgtcgc ctcatccatc
    12421 gccagcttca gcagctgctc aatacgctgt acgcgcacgg cgtgcgccag gttgaacagg
    12481 ccgatcgcag ccgccgcatc acggcggtca gcatcctgca gcagcgcgtc acgctcccgg
    12541 gccacatcag cctcagcagc ctcggcggca accagctcgg cctcgatatc cggcagcagg
    12601 aacgcagcga cgcccgcatc ggggctcaca gtctcgccag cacgcagcgc cgtcttgccg
    12661 tcggcaatca gcccgcgcag gcgttcagct tccgtcctga gcccttccac cacgcgagcg
    12721 gcgtcaatgc gtcgcgtttc cacgtcggct gctgcctgac gcatttcacg cgccacccgg
    12781 cgatcgtcaa gcgcggtaag ttgagcggag gagttaggat ccaccgacag gcaaggaagg
    12841 tcataaacgg gaaaatggtc actcgccatt tcagcaagc
//
