LOCUS       NZ_OW849158            12879 bp    DNA     circular CON 03-SEP-2023
DEFINITION  Serratia marcescens isolate 0 plasmid P3, complete sequence.
ACCESSION   NZ_OW849158
VERSION     NZ_OW849158.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMEA7962736
            Assembly: GCF_905232415.2
KEYWORDS    RefSeq.
SOURCE      Serratia marcescens
  ORGANISM  Serratia marcescens
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Yersiniaceae; Serratia.
REFERENCE   1
  AUTHORS   Alioto,T., Alioto,T. and Gomez Garrido,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-MAY-2022) CNAG-CRG, CNAG, Spain
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 09/02/2023 07:57:52
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,348
            CDSs (total)                      :: 5,217
            Genes (coding)                    :: 5,135
            CDSs (with protein)               :: 5,135
            Genes (RNA)                       :: 131
            rRNAs                             :: 8, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 90
            ncRNAs                            :: 19
            Pseudo Genes (total)              :: 83
            CDSs (without protein)            :: 82
            Pseudo Genes (ambiguous residues) :: 0 of 83
            Pseudo Genes (frameshifted)       :: 29 of 83
            Pseudo Genes (incomplete)         :: 53 of 83
            Pseudo Genes (internal stop)      :: 14 of 83
            Pseudo Genes (multiple problems)  :: 10 of 83
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            OW849158.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..12879
                     /organism="Serratia marcescens"
                     /mol_type="genomic DNA"
                     /isolate="0"
                     /isolation_source="Complejo Asistencial Universitario de
                     Salamanca (Salamanca)"
                     /host="Homo sapiens"
                     /db_xref="taxon:615"
                     /plasmid="P3"
                     /geo_loc_name="Spain"
                     /collection_date="2018"
     gene            complement(join(12717..12879,1..194))
                     /locus_tag="LQ123_RS26580"
     CDS             complement(join(12717..12879,1..194))
                     /locus_tag="LQ123_RS26580"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_070559062.1"
                     /translation="MPRHLQGKTRMPLAGGCYSAGHRLALISLLPVLEARPGDRDDGER
                     SKLALYQESLIKAGQPHAFALHEPSLYRWGAYLKSRRARYLQETDAGVAAASDALDRHA
                     FGRAIGAVLGADDE"
                     /name="hypothetical protein"
     gene            complement(200..583)
                     /locus_tag="LQ123_RS26585"
                     /old_locus_tag="AI2618V1_5082"
     CDS             complement(200..583)
                     /locus_tag="LQ123_RS26585"
                     /old_locus_tag="AI2618V1_5082"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_070559064.1"
                     /translation="MSAFSMLCDRLRHEATLAKSTGAGDALAQVLETGGAAQTFAPIGA
                     PVASPTESVHRARAQSIQDAAFLTEMKQAGVAPADLVMLDGVLASSRGLPDASRAPAFA
                     AVRAQVQQQASLSPAARGINWDE"
                     /name="hypothetical protein"
     gene            complement(584..1240)
                     /locus_tag="LQ123_RS26590"
                     /old_locus_tag="AI2618V1_5083"
     CDS             complement(584..1240)
                     /locus_tag="LQ123_RS26590"
                     /old_locus_tag="AI2618V1_5083"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_119879883.1"
                     /translation="MTEIKTECPDATWLRTTLAEMASDHFPVYDLPCLSVDPNSSAQLT
                     ALDDRRVAREMRQAAADVETRRIDAARVVEGLRTEAERLRGLIADGKTALRAGETVSPD
                     AGVAAFLLPDIEAELVAAEAAEADVARERDALLQDADRRDAAAAIGLFNLAHAVRVQRI
                     EQLLKLAMDEATLLAESDAGRSLYRTVINPDRRLNQLFSTQGAIEILRRNRGMEA"
                     /name="hypothetical protein"
     gene            1500..2087
                     /locus_tag="LQ123_RS26595"
                     /old_locus_tag="AI2618V1_5084"
     CDS             1500..2087
                     /locus_tag="LQ123_RS26595"
                     /old_locus_tag="AI2618V1_5084"
                     /inference="COORDINATES: protein motif:HMM:NF012464.3"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_181654175.1"
                     /translation="MSKTYGYVRVSTDEQTSNSQRDAIIARFPTASILADDGISGTVPP
                     RERPALGILLNQILQEGDTLVIYAIDRIGRNARDALELVEELEKRKVTLVSIREGVDLS
                     SAVGQAVLGIMASFAQMERKLILERQAAGIEAAKSRGQKFGRPTKIGAKEAGEIVMRRA
                     MGVPIATIAKQLNLSRSAIYRHLEKVDAVAPE"
                     /name="recombinase family protein"
     gene            2198..2383
                     /locus_tag="LQ123_RS26600"
                     /old_locus_tag="AI2618V1_5085"
     CDS             2198..2383
                     /locus_tag="LQ123_RS26600"
                     /old_locus_tag="AI2618V1_5085"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_119879885.1"
                     /translation="MINQAATPRYPGLSIEHGEIRQFGKPRHCAANRKGQYQTTLRDSA
                     GRYQTVSIISLYAWEA"
                     /name="hypothetical protein"
     gene            2502..2747
                     /locus_tag="LQ123_RS26605"
                     /old_locus_tag="AI2618V1_5086"
     CDS             2502..2747
                     /locus_tag="LQ123_RS26605"
                     /old_locus_tag="AI2618V1_5086"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_070558916.1"
                     /translation="MAFENIPRRFQRWKVIMVPGAKSYESWDEMVTGENFSEETRMKTY
                     KKHRTKAIDRTVANQEYIHTMTEDGITVRYRLERWR"
                     /name="hypothetical protein"
     gene            2946..3413
                     /locus_tag="LQ123_RS26610"
                     /old_locus_tag="AI2618V1_5087"
     CDS             2946..3413
                     /locus_tag="LQ123_RS26610"
                     /old_locus_tag="AI2618V1_5087"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008324036.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0004803 - transposase activity [Evidence IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="WP_070559148.1"
                     /translation="MKKYTTEQKAQALRLLEQDGATAATVARTMGIPPRTVRDWAKART
                     DAPSNVLSIEEMRERAQRAVEATPQAAIRRLKNHFVQRQFELLQRHATDLQALRTASLQ
                     AMLEKDATMVKAISGLMTSLLKTQERERVIYEIKPGTEADIMREGMNRQQS"
                     /name="transposase"
     gene            complement(4059..5354)
                     /locus_tag="LQ123_RS26615"
                     /old_locus_tag="AI2618V1_5088"
     CDS             complement(4059..5354)
                     /locus_tag="LQ123_RS26615"
                     /old_locus_tag="AI2618V1_5088"
                     /inference="COORDINATES: protein motif:HMM:NF017116.3"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VapE domain-containing protein"
                     /protein_id="WP_119879886.1"
                     /translation="MSQIDENSGTAADNVTPIAAAKVGRPSLQKKYPTTAFPVELEINY
                     RKGRYSSSLENVVAAMRCHSVTGIQLAFDEFFAEEGAFVNGQWYPLSDNLVTELRLRLA
                     AADFEKVTKDNARDAMFYVCDENKFDSAQRWLTAQEWDGKPRVSYFFERCFKCQGDPEY
                     LAAVSLYTWTALAGRVMNPGIKADMVPLLYGRQGARKSTGVRLMSPFPDSYSSFNLNDK
                     DDSLVRRMRGCLIGELEELRGLHGRDSESVKAFFSAAHDEWVPKFKEFKVRNPRRVVFI
                     GTTNNKQILNDSTGNRRYLPMNSGDVDCAAIEKNRSQLWAEALHLFNENGVMWEAAETL
                     ARKVHDEFRVEDPWEDEIAELLKLDVDDCDPTAFVPTKALFSQVGLMIGHTSNKQHQRM
                     AAIMSRLGYEVGRKRINGALVRGYFRRTQAVV"
                     /name="VapE domain-containing protein"
     gene            5882..6373
                     /locus_tag="LQ123_RS26620"
     CDS             5882..6373
                     /locus_tag="LQ123_RS26620"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008324040.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_070558888.1"
                     /translation="MREKTKTLTVRLPVSLIERIEQNAARTGATRTDAVIEALNAGLGT
                     KPEGMDTKLLAAIEALRAEVRALSVGGKPARQTAQQTAPQSAQQPARQIVPRGADPRFQ
                     AVSDEADQLIVSMTAENATLPAIASALNAAGHRTATGQEWNTSRVRDYRHKLRESGLLN
                     "
                     /name="hypothetical protein"
     gene            6438..6929
                     /locus_tag="LQ123_RS26625"
     CDS             6438..6929
                     /locus_tag="LQ123_RS26625"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_061351425.1"
                     /translation="MAIGDDAIRDAFYAFTQQAEEMDDKGLPQEVWETPCFTYLMTKKQ
                     FNQMKVVCQRNGWDIPASPAIPITWAMFRHVLSARNSKDKLSWQECAEILATAFSVQSN
                     VYVNRDYSEQTIVLNAVRRINVAGAGFFAMAIVDVSENNLAPVTAYHATEAKCKAIQRG
                     "
                     /name="hypothetical protein"
     gene            7376..7960
                     /locus_tag="LQ123_RS26630"
                     /old_locus_tag="AI2618V1_5090"
     CDS             7376..7960
                     /locus_tag="LQ123_RS26630"
                     /old_locus_tag="AI2618V1_5090"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004589499.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_061351424.1"
                     /translation="MDITISDATYSRLAAQAKGFETPEQVINRLIDVVEIDHDTRPELF
                     FNPEGEADFKKALLKSKQAKVEMFKRDGSCETGVWNARAISEESSVRANIWSGYLRGWK
                     EKGIVRAVFTVQEVPDLPGAAESVQWNDYTISRTFSGGISVQRNGMPVTIVKPFLRDVA
                     HDLKISLLNSNGNEMNTRQLGAAIIKKLNNS"
                     /name="hypothetical protein"
     gene            complement(8215..8673)
                     /locus_tag="LQ123_RS26635"
                     /old_locus_tag="AI2618V1_5091"
     CDS             complement(8215..8673)
                     /locus_tag="LQ123_RS26635"
                     /old_locus_tag="AI2618V1_5091"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_088765952.1"
                     /translation="MKSKTELREAATARSLAVIATEMSEWSLDGFSHLKLPNFSAGERQ
                     QTLSGSVVVDRPPFDYEWAGTEKFNTLATRALQVKLPASRERNYAWLCGVERETLATAL
                     LVELFSVTGCVAFAGLGKVADLAFLTLDESEAGQIRAAMLQWLDGAAA"
                     /name="hypothetical protein"
     gene            complement(8899..10080)
                     /locus_tag="LQ123_RS26640"
                     /old_locus_tag="AI2618V1_5092"
     CDS             complement(8899..10080)
                     /locus_tag="LQ123_RS26640"
                     /old_locus_tag="AI2618V1_5092"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_088765953.1"
                     /translation="MAFDNSHLTDAGLFWRAVSAAGAPVDREDWLRLCSGIACWASLCG
                     EDGLAAIEAWSTRHNRGSAHHRSQYRHFLKLKGVTNPEAMAQVFLRFSGEVYWRLDSNR
                     TPPSTEQVAALAERKRRSIEAVARREDADRRKADKAAADAVRMLAKGDGNPAYTPYWRN
                     KTTIARRGGVSLPPLPADLRVGGLFRSFEPRAYWSRCLLVPAYRLTDDRQLVGDALEAI
                     CGVCSAGGKTGDKFSPAGTQKAGRFYPMPGFMDVLDTSPHAPYSPLFVCEGFATAVALH
                     HLTKGKVAVCAAFSIAGFGSCVASLRRFWPDVDVMLVPDHGEAYRLAHKAAYGDEREPV
                     PTIPGAAVVSFDGLDRFTPRDNLDWFDVLVEEGEDRARELLRYAVRHARLERR"
                     /name="hypothetical protein"
     gene            complement(10067..10276)
                     /locus_tag="LQ123_RS26645"
     CDS             complement(10067..10276)
                     /locus_tag="LQ123_RS26645"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_088765954.1"
                     /translation="MKKRIYTADLAALLNVSLRTLSRLSSRGIVPTPAGRSLRGGHYWL
                     AGDPVLKRFIADQRRPGRAPYGVR"
                     /name="hypothetical protein"
     gene            10632..11921
                     /locus_tag="LQ123_RS26650"
                     /old_locus_tag="AI2618V1_5093"
     CDS             10632..11921
                     /locus_tag="LQ123_RS26650"
                     /old_locus_tag="AI2618V1_5093"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_157698538.1"
                     /translation="MNDDNDTTEATQPSTEALKCVGAAERFPDIMPGVLFVTCPGGCSL
                     RVEACRQIYEQSHLDRTIENPHLECHRCPTGLALWVGTEQPPDAPLTTPADTRKLCPRC
                     SRKDNRLIAPNKPGSSLCVSCWNREREATIGANARGRVNRTPPFVSPFLIGIGDGWQVW
                     YGIHQGEALVRAMRANPGARFHDRRPGPVGQTRRDGFVYYCPEHREPLRWNGGDGHAGE
                     VELACPRCQPWAAPLSVAPTFQTVSFQTPHDAAHQYRNATLPDNAVWTSSVCADCKAAP
                     LVISKAPVKGKPRREIVVSCPSCDSSASARPGGRTWTDEHIAVPEFAQNETRSLAKIPV
                     ILPQGEQPQLLKRPGTGRGPGRPRKRIPLTLDRVPESRFNRLALSVLAAVGRWDYINDI
                     IRRIDRNRGDAATLIALADHIRTNRPERDL"
                     /name="hypothetical protein"
     gene            11918..12559
                     /locus_tag="LQ123_RS26655"
                     /old_locus_tag="AI2618V1_5094"
     CDS             11918..12559
                     /locus_tag="LQ123_RS26655"
                     /old_locus_tag="AI2618V1_5094"
                     /inference="COORDINATES: protein motif:HMM:NF016255.3"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ProQ/FINO family protein"
                     /protein_id="WP_070559060.1"
                     /translation="MTETTRPILTIKRRNRTVYVPPEKAAKSEPQPAERTTSKAKVQPK
                     AKAPQKPAQKPTAAKPKKTPEQVAEGIRRQEENDRRQQDIAIANKSKKALANRVTKAFL
                     KEHWPDLLTRGVDRRPMAKGIIEQILTRGAELNMPPEADRKAVRRILGIVTGTSSYQQS
                     LIDQCMRYDLDGNPTEPATPEEAENAKARLTEIKAFRRKARQAKGEKKGA"
                     /name="ProQ/FINO family protein"
ORIGIN
        1 gcgaacgcgt gcggttgccc ggccttgatc agcgattcct gatacagcgc cagcttcgat
       61 cgttcaccat catccctgtc accaggacga gcctccagaa caggcagcaa cgagatcagc
      121 gcaagacggt ggccagcaga gtaacaacca cctgccagcg gcatccgcgt cttaccctgc
      181 aggtggcgcg gcatcggctt tactcgtccc aattgatacc ccgggcagca ggggagagag
      241 acgcctgttg ctgcacctga gcacgcaccg cagcgaacgc cggagcacgc gacgcatcag
      301 ggagtccgcg agaggaggcc agcacgccgt caagcatcac cagatcggca ggagccacgc
      361 ccgcctgttt catctcagtc aggaacgccg catcctggat ggactgagca cgcgcccggt
      421 gaaccgactc cgtaggagag gcaaccggag ccccgatcgg cgcgaacgtc tgcgcagcac
      481 cgcccgtctc cagcacctgc gccagcgcgt cgccggcccc ggtagatttt gccagcgtcg
      541 cctcatggcg aagccggtca cacagcatcg aaaatgcaga catttacgcc tccatgccgc
      601 gattgcggcg cagaatttcg atcgcaccct gcgtggagaa cagctggttc aggcggcgat
      661 caggattgat aacagtacgg tacaaactgc gccccgcgtc ggactcggca agcagcgtcg
      721 cctcatccat cgccagcttc agcagctgct caatacgctg tacgcgcacg gcgtgcgcca
      781 ggttgaacag gccgatcgca gccgccgcat cacggcggtc agcatcctgc agcagcgcgt
      841 cacgctcccg ggccacatca gcctcagcag cctcggcggc aaccagctcg gcctcgatat
      901 ccggcagcag gaacgcagcg acgcccgcat cggggctcac agtctcgcca gcacgcagcg
      961 ccgtcttgcc gtcggcaatc agcccgcgca ggcgttcagc ttccgtcctg agcccttcca
     1021 ccacgcgagc ggcgtcaatg cgtcgcgttt ccacgtcggc tgctgcctga cgcatttcac
     1081 gcgccacccg gcgatcgtca agcgcggtaa gttgagcgga ggagttagga tccaccgaca
     1141 ggcaaggaag gtcataaacg ggaaaatggt cactcgccat ttcagcaagc gtggtacgca
     1201 gccaggtcgc gtccgggcat tcggttttga tttcggtcat ggtttggttc tcagcaagtt
     1261 atcagcaaag cggcagcaaa cgccgctcag acagcatgcc gtcacgacac cgcgcagaca
     1321 tcaacgcaga gggcgcaggg ctctcgccca gcgcggagag ccgcctggag gccgtcgcta
     1381 atcccctaca ttccgggaca cccgacaaag cgacgaaata gacactttag cgatagactt
     1441 tcggtacagt tgtggcatgt tgtgtcgaaa gagacgtatc ggtcagagga gagaaaaaag
     1501 tgagcaaaac atacggttac gttcgcgtat caaccgacga acaaaccagc aacagccagc
     1561 gcgacgccat catcgcccgg ttcccaacag cctccatcct cgccgacgac gggatcagcg
     1621 ggacggtacc accacgcgag cgtccagccc tcggcatcct cctgaaccag atcctgcagg
     1681 agggcgacac gctggtcatc tacgcgatcg accgcatcgg caggaacgcc cgggacgccc
     1741 tcgaactggt cgaggagctg gagaaacgaa aagtaaccct ggtcagcatc cgcgagggtg
     1801 tcgatttgag cagcgccgtc ggacaggccg tcctcggcat catggcgagt ttcgcgcaga
     1861 tggagcgcaa gctcatactg gaacgccagg cggcagggat cgaggccgca aagagccgtg
     1921 gccagaagtt cggacgcccg accaagatcg gcgcgaaaga agcgggggag atagtcatgc
     1981 gccgcgccat gggggtacca atagccacca tagccaagca gttaaatctg agcaggagcg
     2041 cgatttaccg ccaccttgag aaggtcgacg cggtagcgcc ggagtaagag agagcgcagc
     2101 ggtgtaggtg gctccaacca ttccacaccg ccgcaaccca gcccggggaa cgcatgagga
     2161 gcagacccgg gcaccattcc caacaaggaa cagaaccatg ataaaccaag cagcaacacc
     2221 gcgctatccc ggcctgagca ttgaacacgg cgagatccgc cagttcggca agccccgcca
     2281 ttgcgccgcc aaccgcaaag gccagtacca gaccaccctc cgcgacagcg ccggtcggta
     2341 ccagacagtc agcatcatca gcctttacgc ctgggaagca tgaccataac gaaagcctta
     2401 caggtgtaag cagcaagcaa taacaaaagc cttacgccat tacgaaccac ttacaggggc
     2461 gcgggagcgc ccccagaaac cagaatcata aggagagaac gatggcattt gaaaacattc
     2521 cccgtaggtt ccagagatgg aaggtaatca tggttcccgg agcaaagtca tatgagtcat
     2581 gggacgagat ggttaccggc gagaacttct ccgaagaaac caggatgaaa acgtacaaaa
     2641 agcaccgcac caaggccatc gaccgcaccg tggcaaacca ggagtacatc cataccatga
     2701 cggaggacgg gatcaccgtc aggtaccgcc tcgaacgctg gcgctaaccc cagctaggag
     2761 cgcagcgact gctgcgcctc ctcccttacc cagaacgcac cagagccatt ctaagcgcct
     2821 cagccacaaa aatacccaac cgcacgacca cgcacgcaca aacgccgtgt accccccaaa
     2881 aacccccgcc attttcagcg cgtgacgttt caatacagga gagaaaccaa ccggagcagg
     2941 acaccatgaa gaaatacacc accgagcaga aagcccaggc gctcagacta ctggagcagg
     3001 acggcgcaac cgcagccacc gtcgcacgca ccatggggat cccaccccgc accgtcagag
     3061 attgggcgaa agcccgcacc gacgcaccca gcaacgtcct cagcatcgag gagatgcgcg
     3121 aacgcgcaca gcgagccgtc gaggccaccc cacaggcagc gatccgacgc ctaaaaaacc
     3181 actttgtaca gcgccagttt gagctgctac agcgccacgc caccgacctg caagccctcc
     3241 gcacagcttc gctacaggcc atgctggaga aggacgccac catggtcaaa gcgatcagcg
     3301 gccttatgac atccctactc aagacgcagg aacgcgagcg cgtcatctac gagatcaagc
     3361 caggcaccga ggccgacatc atgcgcgagg gcatgaatcg ccaacagagc tgaaaacggc
     3421 gggaaaaccg ccttttaccg ccgctttacc gccgcagaaa acccgggagc ccgcgaaata
     3481 cgcggatccg cacgttaacg agttgttacc gctcgcgtgc gcgagggcaa gccctcacgc
     3541 agaaccaaca gacgaccacc cagcgcgagg cgaaagcctc gtgccctcag cgccacccaa
     3601 acctccgatc cccctcagaa ccactaccac cgaccatccc ggcacgacga acccatccac
     3661 cgatctaata agacaagcaa agtgcatccg gcagggtgca gctgcggcgc gtcgattcca
     3721 agatgatcca cccgttccac ccgatccggc atagattcat aaatagtaaa aaaaacaact
     3781 aattgttcaa ttagtgagca tttaccccct atttacccaa tttattcatt ttttgttttt
     3841 aattagaaaa tagggtggaa cgggtggaac acaacaatga aagcctttaa acacgaggcc
     3901 ttagctgttc catccacggg cggaacacgg gtggaacggg tggaacaccc gggtggaaca
     3961 ggtggtacaa aaacggcgtg atgatccacc cgtgatccac ccgggtggaa caataaaaaa
     4021 ggggagcata tagctcccct cttacggaaa agtaaccctt acacgacagc ttgcgttcga
     4081 cggaagtagc cacgaactaa cgcaccgttt atgcgcttcc tgccaacctc atagcccaat
     4141 cgggacatga tagccgccat gcgctgatgc tgcttgttgc tggtatggcc aatcatgagc
     4201 cctacctgag agaacaaggc cttcgtcggc acgaaagcag tcgggtcgca gtcgtcaacg
     4261 tccagcttga gcagctcggc gatctcgtct tcccacggat cctcgacgcg gaactcgtca
     4321 tgcaccttac gcgccagcgt ttcagcggcc tcccacatca ccccattctc attgaacagg
     4381 tggagcgctt cagcccacag ctgcgagcgg tttttctcga tggccgcgca gtccacgtcc
     4441 ccggaattca tgggcaaata gcggcggttc cccgtcgagt cattgaggat ctgcttgttg
     4501 ttcgtggtac cgatgaacac cacgcggcgc gggtttcgca ccttgaactc tttaaatttc
     4561 ggcacccact cgtcgtgggc agcggagaag aacgctttca ccgattcgga gtcgcgcccg
     4621 tggaggccgc gcagctcctc cagctcgcca atcaggcacc cacgcatacg gcgcactagg
     4681 gagtcgtcct tgtcgttcag gttgaagctg gagtaggagt cagggaatgg cgacataagg
     4741 cgaacgcccg tcgatttgcg ggcaccctgt cgcccgtaca gcagcggaac catgtcggcc
     4801 ttgattccgg gattcattac gcgcccggca agcgccgtcc aggtgtagag gctgaccgcc
     4861 gccaggtact cgggatcccc ttggcatttg aagcaccgct cgaagaagta actgacgcga
     4921 ggtttgccgt cccattcctg agccgtcagc caacgctggg cgctgtcgaa tttgttctca
     4981 tcgcagacgt agaacatggc gtcgcgggca ttgtccttgg tcaccttctc gaagtcggca
     5041 gcagcgaggc gcagacgcag ctcggtaact aggttgtcgg acagcgggta ccattgcccg
     5101 ttcacgaacg ccccctcctc cgcaaagaac tcatcgaaag cgagctggat gccggtgacg
     5161 gaatggcagc gcatagcggc gacaacgttc tcaagagagg acgagtagcg ccccttccgg
     5221 tagttgatct ccagctccac gggaaacgcg gtagtcgggt attttttttg tagagacggg
     5281 cgtcccacct tggcagcggc gatcggcgtt acgttgtcgg cagcagtgcc ggaattttca
     5341 tcaatttgtg acacgcaatt actcctttaa aaacgtagga gtcggcgtca ggcgggggct
     5401 tacgagggaa attcacactt gcgcgatctt atcgacgtgg tacacttctc tttgagtttg
     5461 aggagtacgc tgcgcaagtg ctattcttcc ttcgagaacg tcccgctaag acgtgactcg
     5521 aattaatcgg aggagttacc agctcccccg gcagaaaaag gtgaccaccc aacaggtcgc
     5581 ctttttttgt gcccgaagat ccccaaccgg atccgcagac gccagatcag cttacccgat
     5641 cccaaccctc cacgccactt agcgccgcgc acttatcgcg ctgtcgtgat cacgcccagc
     5701 tcaatctctg cgccgcctct gctatttatc catgtacaca aacggcaccc cggcgacgca
     5761 aagccgtcgc ccctctgtgc acgacaactg cacgacgtcg aattcgacgc gcacgacaaa
     5821 acgcattaca ctacgcaaga caaacagcac gacaaaacgc acgacgtgga gagcagcagc
     5881 catgagagag aaaaccaaaa ccctgaccgt tcgcctaccc gttagcctga tcgaacgcat
     5941 cgagcagaac gcagcacgaa ccggagcaac ccgcacggat gctgtcatag aggcgctgaa
     6001 cgccggactt ggcacgaagc cggaagggat ggacaccaaa cttttagctg ccatcgaagc
     6061 gctgagggct gaagtcaggg cgctgtccgt cggcggtaaa cctgcacgac aaaccgcaca
     6121 acaaacagca ccacaaagcg cacaacaacc tgcaagacag atagtccccc ggggagccga
     6181 tccgcgcttc caggccgtca gtgatgaggc tgaccagctc attgtcagca tgaccgcaga
     6241 gaacgcgact ctgcccgcca tcgcgtcggc actgaacgca gcagggcacc ggacagcgac
     6301 gggacaggag tggaacacca gccgtgtccg ggactatcgc cataagttgc gggaaagtgg
     6361 gctactgaat tagcagtcct aagtgacata gctaaatatg ataaaattcg aacataaaaa
     6421 ttttacaagg aaaagaagtg gctatcggtg atgatgctat ccgtgacgct ttctatgctt
     6481 ttacacagca agctgaagaa atggatgata aaggtctccc tcaggaagtt tgggagacgc
     6541 cttgttttac ctatctgatg actaagaagc agttcaatca aatgaaagtt gtttgtcaga
     6601 gaaacggctg ggacatacct gcatcaccag caataccgat cacttgggca atgtttaggc
     6661 atgtgctatc tgctcgtaac tcgaaggata agctaagttg gcaagagtgt gcggagattt
     6721 tggcaactgc attctcagtg cagagcaatg tgtacgttaa cagagattac tcggagcaga
     6781 ctattgtgct caatgctgtt cgtcgcatta acgttgctgg ggctggcttt ttcgcaatgg
     6841 cgatagttga tgtctctgaa aataatttgg cccccgtgac tgcataccat gcaacggagg
     6901 ccaaatgtaa agctatacag cgagggtgat aggaaggacg cccatttaag caattctcct
     6961 caatttaatg agaatgaacc ataacgccta aatatttccc ttcattggtt cctttcggat
     7021 ctagcagcat cggcggtttt ctgctgtcta tcaaattcac tgttattact aggaagccgc
     7081 aacataactt cccaacagga gaccagcctc ctgactgccc agcgcaaagg gttaattact
     7141 ggttaatacc ccctgcgaat gctcttgcag tacaacaata gtaggctatt gttgacgtag
     7201 attcaactgg tttgtttata accaagcggc acgaggagcg ggtttacagg tttttatagc
     7261 tctttagagg cggttaacca tattgcgata tcaggtaatt atagatcttg aaatcattaa
     7321 atttatcaat tatgattaat tttatgatta atttttgatc tatagaggta ctttgatgga
     7381 tattacgata tctgacgcta catatagccg tcttgctgca caagcaaagg gatttgaaac
     7441 tcccgaacag gtaataaacc gtctgatcga tgttgttgaa atcgatcatg acacacgccc
     7501 tgaacttttt tttaatcctg aaggtgaagc ggattttaaa aaagcgttac taaaatcaaa
     7561 acaggccaaa gtcgaaatgt ttaaaaggga tggttcctgt gaaactggag tatggaatgc
     7621 tcgtgcgatt tcagaagaat catcagttcg ggcaaatatt tggagtgggt atttgcgtgg
     7681 atggaaggaa aaagggattg ttcgtgcggt tttcactgtc caggaggttc ctgacttgcc
     7741 aggagcggct gaaagtgtgc agtggaatga ttatacaatc agtcgcactt ttagtggcgg
     7801 tatttcagtt caaagaaatg gcatgcctgt aactattgtg aagccatttc tacgtgatgt
     7861 tgcgcatgat ttaaaaatat cattgctaaa tagcaatgga aatgaaatga atactcggca
     7921 gcttggcgca gcgatcataa agaagttaaa taactcttaa catcgatgct tcacgcagag
     7981 gagcgacggc tcaacgccgc cgccggtcag agttctactg cgacgaatac gcaccattca
     8041 tagctggcga ggcagaacgc ccgccacctg tcatcagacg cccggtcaac acactccagc
     8101 cataaccgcg ccgcagcaag gtggtcgcag cgcaccgggt cgccccgcag ttccgtcgcc
     8161 atggcctcct cgatcagtcg cccttcccac tccagctgat cgaggatcga gcccctacgc
     8221 cgccgcccca tcgagccact gcagcatcgc cgccctgatc tgccccgcct cgctctcgtc
     8281 cagcgtcagg aacgccagat cggcaacctt acccagcccg gcgaacgcca cgcagccggt
     8341 gacggagaac agctccacga ggagcgccgt cgccagcgtc tcccgttcaa cgccgcacaa
     8401 ccaggcgtag ttacgctcac gcgatgccgg aagtttcacc tgcagcgcac gggtggccag
     8461 agtgttaaat ttctcggtac cagcccactc gtagtcgaac ggcgggcgat caaccaccac
     8521 cgacccggac agcgtctgct ggcgttcccc agcggagaag ttcggcagct tgaggtggga
     8581 gaacccatcg agcgaccact ccgacatttc agtggcgatc accgccagag agcgagccgt
     8641 cgcggcctcg cgtagttcag tctttgattt catgtgccct cctttgggct aaaaaaaaac
     8701 ccgacatcaa gacgaggccg ggctttatgc tgctgtgaga aaccgatcgc aggatagcgt
     8761 cacgacggca gcgccggtgc gtcgctttag tccgtctcat caaaaaagca tcggtagtgt
     8821 ctcgaaagtc gttcgctaaa ccagacgcca cgacggcaaa aaagatgtcc cgaaaggcgc
     8881 accattcgga cacgccaatc aacgccgctc aagccgggca tgacgaaccg cgtagcgcag
     8941 cagctcacga gcccgatctt ccccttcctc aaccagcacg tcgaaccagt cgaggttatc
     9001 ccggggcgtg aagcgatcga ggccgtcgaa cgacacaacc gccgcgcctg gaattgtcgg
     9061 gaccggctct cgctcatcgc cataggccgc tttatgcgcc aggcggtacg cttcgccgtg
     9121 atccggtacc agcatcacat caacatctgg ccagaaccgg cgcagcgacg ccacgcagct
     9181 gccgaacccg gcaattgaga acgccgcgca gactgccacc ttgcccttcg tcagatgatg
     9241 cagggcaacc gccgtggcga acccctcaca gacgaacaga ggcgagtagg gcgcatgtgg
     9301 tgaggtatcg agcacgtcca taaagccggg catcggatag aaccgtcccg ccttttgggt
     9361 acctgcaggg gagaacttgt cgccggtttt gccgccagca gagcagacgc cgcagatggc
     9421 ctccagcgcg tcgccaacca gctggcgatc atcggtcagg cgataggcag gaacaagcag
     9481 acagcgcgac cagtacgccc tcggttcgaa cgagcggaac aagccaccca cacgaaggtc
     9541 agcggggagg ggcgggaggc tgacgccacc acgcctggcg attgtggtct tattgcgcca
     9601 gtacggggta taggccggat taccgtcgcc tttcgccagc atcctgaccg catcagccgc
     9661 agccttatcg gccttgcgcc ggtcggcatc ttcgcgtctg gccaccgcct cgatcgatcg
     9721 gcgtttccgt tcagcaagag cagcaacctg ttcagtcgac ggcggcgtgc gatttgagtc
     9781 gagccgccag tacacctcgc ctgagaaccg caggaatact tgcgccatgg cctcgggatt
     9841 ggttacgcct ttcagcttca ggaagtgccg gtactgcgac cggtgatgcg cagatccgcg
     9901 attgtggcgg gtagaccagg cctcgatagc agcaagcccg tcctctccgc agagagatgc
     9961 ccagcatgcg atgccagaac agaggcgcag ccagtcctcg cggtcaaccg gagccccagc
    10021 cgcagagacg gcacgccaga acaggccagc gtcagtcagg tgagagttat cgaacgccat
    10081 aaggagccct cccgggacga cgctggtcgg caataaagcg tttgagcacg ggatccccag
    10141 ccagccagta atgcccgcca cgaagggaac gccctgccgg agtcggaacg atcccccgcg
    10201 aactcaggcg ggagagcgtg cgcagcgaca cgttcagcag cgcagcgagg tcagcggtat
    10261 agattcgttt tttcattggg agtaccagat aggtgccccc ctcagcttaa cgggcatcgg
    10321 ggggcgggag tgacgattat cgataaagcc gcccttgagg acttaccgca tagcggcagg
    10381 acagcagccc ttctcgctta ctcgcacctg ccaaggacga agcgcgcatc ctcgtttaca
    10441 accccgcctc gttggggagg agggaaagcg gcaccgggcg atccggtttc atgtttccca
    10501 actgctcgtc aggaatcagt aagacaagct taacacaatt aacgccaaag tggcgttttt
    10561 tgtgagatac taaaaaagac gcacagccag tgctggcgag gtctggcgac catttcgacg
    10621 cagggggagc agtgaacgac gataacgaca cgacagaagc gacgcagccg tcaaccgagg
    10681 cactgaagtg cgtaggcgct gcggagcggt tccccgacat catgcccggc gttttgttcg
    10741 tcacctgccc cggcgggtgc tccctccggg tcgaggcatg ccgacagatt tatgagcaga
    10801 gccacctcga tcgcacgatt gaaaaccccc acctcgagtg ccaccggtgc cccactggcc
    10861 tcgcgctttg ggtcggtacc gaacagcccc ctgacgcacc actgaccacc ccggcagaca
    10921 cccgtaagct ctgcccccgt tgcagccgga aagacaaccg cctgatcgcc cccaataagc
    10981 ccggttcgag cctgtgcgtc tcctgctgga accgcgaacg cgaagccacc atcggagcca
    11041 acgcacgcgg gagagtcaac cgcaccccac cgttcgtctc gccgttcctg atcggcatcg
    11101 gcgatggctg gcaggtctgg tacggcatcc accagggcga ggcgctcgtc cgcgccatgc
    11161 gagccaaccc gggcgcacgg ttccacgatc gccgaccagg cccggtcggg caaacacgcc
    11221 gcgacggttt cgtgtactac tgccccgaac accgcgagcc cctgcgctgg aacggtggcg
    11281 acgggcacgc cggagaggtg gagcttgctt gtcccaggtg ccagccatgg gcggcacctc
    11341 tcagcgtcgc ccccacgttt cagacggtca gcttccagac accgcatgac gccgcgcacc
    11401 agtaccggaa cgccaccctg ccagacaacg cggtctggac atcgtcggtc tgcgctgatt
    11461 gcaaagccgc gcccctggtg atcagcaagg caccggtcaa gggcaagccg cgacgggaga
    11521 tcgtcgtctc ctgcccgtcc tgcgactcca gcgcatcagc caggcccgga ggcaggacat
    11581 ggacagacga gcacatcgcg gtgcccgagt tcgcgcagaa cgagacgcgc agcctggcga
    11641 agatccccgt tattttgccg cagggggagc agccgcagct gctcaaaaga ccagggacag
    11701 ggcgcggtcc aggacgcccc cgcaagcgca tccccctgac cctcgaccgg gtaccagaga
    11761 gccggttcaa ccgcctcgcc ctttccgtcc ttgccgccgt cgggcgctgg gactacatca
    11821 acgacatcat ccggcgcatc gatcggaacc gcggcgacgc cgccaccctg atcgcccttg
    11881 ccgaccacat ccggaccaac cgaccagaga gagatttatg accgaaacca cccgtccgat
    11941 cctgaccatc aagcgacgca accgcacggt ctacgtcccg ccggaaaagg ccgcgaaatc
    12001 tgagccgcag ccagccgaac ggactaccag caaggcgaag gtacagccaa aagcgaaagc
    12061 cccgcagaag cccgcacaga agcccacagc ggcaaagccg aaaaagacgc ctgaacaggt
    12121 cgccgagggg atccgcagac aggaggagaa cgaccgccgc cagcaggaca tcgcgatcgc
    12181 caacaagtcc aaaaaggcgc tggccaaccg ggtgaccaaa gcattcctga aagagcactg
    12241 gcctgacttg ctgacccggg gagttgaccg tcgccccatg gcaaagggca tcatcgagca
    12301 gatcctgacc cgaggcgcag agctgaacat gccgccagag gcagaccgca aagccgtccg
    12361 tcgcatcctg ggcattgtca cgggtacgag ctcgtaccag cagagcctca tcgaccagtg
    12421 catgcgctac gacctggacg gcaaccccac cgaaccagca accccggagg aggccgaaaa
    12481 cgccaaagcc cgcctgacag agatcaaggc attccggcgc aaggcacgcc aggcgaaggg
    12541 cgaaaaaaag ggcgcataac gcgccccgtc tcacccagca ccatgtaggc gcagcacgac
    12601 gttcagcagc acggcgagca gctgcgacac gttgcgcgat ccccctggcc tttcgcgcag
    12661 caacaacccc gtcagggatc accacctcag ggatgaccag acgcgagacg gcaaactcac
    12721 tcatcatcag cccccaggac cgcaccaata gcacgcccga aagcatgccg atcaagcgcg
    12781 tctgaggccg cagcaacacc tgcgtctgtc tcctgtaaat accgggcgcg gcggctcttc
    12841 agatacgccc cccagcgata cagcgacggc tcatgtaac
//
