LOCUS       NZ_MF150124             9619 bp    DNA     circular CON 09-JAN-2024
DEFINITION  Klebsiella pneumoniae strain A64216 plasmid pKP64216c, complete
            sequence.
ACCESSION   NZ_MF150124
VERSION     NZ_MF150124.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN07135314
KEYWORDS    RefSeq.
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 9619)
  AUTHORS   Cassu-Corsi,D., Martins,W.M.B.S., Nicoletti,A.G., Almeida,L.G.P.,
            Vasconcelos,A.T.R. and Gales,A.C.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-MAY-2017) Labinfo, LNCC - Laboratorio Nacional de
            Computacao Cientifica, Rua Getulio Vargas 333, Petropolis, RJ
            25651070, Brazil
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method              :: Newbler v. 3.0
            Genome Coverage              :: 23000x
            Sequencing Technology        :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider          :: NCBI RefSeq
            Annotation Date              :: 01/09/2024 02:07:23
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision :: 6.6
            Features Annotated           :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                :: 11
            CDSs (total)                 :: 11
            Genes (coding)               :: 11
            CDSs (with protein)          :: 11
            Genes (RNA)                  :: 0
            tRNAs                        :: 0
            ncRNAs                       :: 0
            Pseudo Genes (total)         :: 0
            CDSs (without protein)       :: 0
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            MF150124.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..9619
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="A64216"
                     /isolation_source="urine"
                     /host="Homo sapiens"
                     /db_xref="taxon:573"
                     /plasmid="pKP64216c"
                     /geo_loc_name="Brazil: City of Sao Paulo, State of Sao
                     Paulo"
                     /collection_date="2014-10-31"
     gene            669..2633
                     /locus_tag="KP64216c_RS00005"
     CDS             669..2633
                     /locus_tag="KP64216c_RS00005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004178196.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TraM recognition domain-containing protein"
                     /protein_id="WP_004178196.1"
                     /translation="MFNTDSLAWKWHIPELARQIYPWVSWLYQEYYGLAGAFLVIGLFF
                     GLAELWAGRMRFVGLSHKERREYADRYKRDNKRPAPFSVLASLDSPGRMVRARRHVWNY
                     AYWLTGAAGLALLGGLVVAVFIESWGETVLRPDLYANADYYLLQPANLFGIAWCAGGLA
                     VGIVLARLLAFLLLDGHFAAADEAVNAKLNQESRRSSQRTGEMTDVRHLHFGEPVPVNA
                     LADFSSEQARQEQAVFLGKDEQGKPVLVPRDTWRKTNIQILGLPGSGKSVMATNALIRC
                     VRDFGDAVVYFDPKGDAWAPHVFRAHCPDFTLLDLRPGKPAQLNLFRDLDQYALKNLLI
                     AGLNLGETGDVADHYRISEQKAAKLIAEQFPQGANIQQVLAAAYALPEALKKDVKGLIT
                     RLENVADLSVLQTDSGIDVAGIINGGGCLYVIGSMDDEAVIRVQKMLFARCAQIIIARD
                     EFREWPHVSVMLDEIKYLLSKYVLNALGTLRSRDCNLLLAHQSLGDFGQCGQDLPAEFV
                     KTTVLDNTPIRWFYRAASLESAQWAAGQTGEIRVDVERRRASREAGNVEHISGDSFIQK
                     EARPLFDVNTLQHLPDGFAVMTGLGVARMAFSSPLRVERREIPLQRFPVLAKTDPLAEF
                     RPPADGGGPKADDDFAGIY"
                     /name="TraM recognition domain-containing protein"
     gene            2633..3364
                     /locus_tag="KP64216c_RS00010"
     CDS             2633..3364
                     /locus_tag="KP64216c_RS00010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobC family replication-relaxation protein"
                     /protein_id="WP_004152551.1"
                     /translation="MALELYNVSHAKRQARNAEKTRLTLRWLREELCSTAELVARRLGI
                     AAVQPVYRFLDSLVAKGLLVRTKYPVDGRQVSVWGLTPHGVAFSFDEDEPLADVIPFQP
                     SRVSAAHLPHRLAVQSLRLDMEARGATGWRILHRLSLKGMKVPDALAELDGKTVAFEVE
                     RTVKSRRRYQEVVSGYLFNRKANGIDEIWYICPDRATQVRVQRAILSVDEIVNPQTGEA
                     RKTAELDRERLFACFKFMTTE"
                     /name="MobC family replication-relaxation protein"
     gene            3371..3901
                     /locus_tag="KP64216c_RS00015"
     CDS             3371..3901
                     /locus_tag="KP64216c_RS00015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_004153058.1"
                     /translation="MALYMVFIEDAEDRNGERCIMPTSEHLEDMVVLAWQTGAYVFCFV
                     DRAQHLAMMKSIGMYDERLNSDEKATYFFTGKNPQWERNKPTGMKLCDYLYRKVERFAI
                     ENGVQVVDAGKCSPEQINAMIDVVSERHGESAVNEKLKAELMREYNSRYFNVPVPELPE
                     DKPARRWWPFGKK"
                     /name="hypothetical protein"
     gene            complement(3929..4108)
                     /locus_tag="KP64216c_RS00020"
     CDS             complement(3929..4108)
                     /locus_tag="KP64216c_RS00020"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rop family plasmid primer RNA-binding protein"
                     /protein_id="WP_000165971.1"
                     /translation="MTKQEKTALNMAKFIKEQSLLLLDKLNELDMDTPADMCERLHEDA
                     ETLWQVMRDKLGEE"
                     /name="Rop family plasmid primer RNA-binding protein"
     gene            4177..4554
                     /locus_tag="KP64216c_RS00025"
     CDS             4177..4554
                     /locus_tag="KP64216c_RS00025"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000312627.1"
                     /translation="MAWVTVRQATELTGKARSSLYRDMAKGRVSYRTEADGGRVVDTSE
                     LIRVYGELRQDETHERDELRLSGETEKMASDALIAEIKALREEVAGLRQEMQSMRLLEH
                     KPETAETPAGTPRRWWPWGKR"
                     /name="hypothetical protein"
     gene            complement(4616..4915)
                     /locus_tag="KP64216c_RS00030"
     CDS             complement(4616..4915)
                     /locus_tag="KP64216c_RS00030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001146176.1"
                     /GO_function="GO:0008657 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) inhibitor activity
                     [Evidence IEA]; GO:0042803 - protein homodimerization
                     activity [Evidence IEA]"
                     /GO_process="GO:0030541 - plasmid partitioning [Evidence
                     IEA]; GO:0051290 - protein heterotetramerization [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_001146176.1"
                     /translation="MPYDVEWKQGAIEDVTTLFDYIAENSSLWDAQNVTDRVLAAADKL
                     ADFPRLYEVDSRYGEDVRRISLMGQHVLYDVDDQTRKVRVLAVVGQRQNPHIVL"
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            complement(4905..5168)
                     /locus_tag="KP64216c_RS00035"
     CDS             complement(4905..5168)
                     /locus_tag="KP64216c_RS00035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000072676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000072676.1"
                     /translation="MSNTTHYENANFLRELAESLPRILPEGGPDKAALLQRLANEELAQ
                     AEYEDQVRAKVTAARADTRPGMTTEQLRQRLHGRYQELRDAV"
                     /name="hypothetical protein"
     gene            complement(5474..5893)
                     /locus_tag="KP64216c_RS00040"
     CDS             complement(5474..5893)
                     /locus_tag="KP64216c_RS00040"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016247941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Exc2 family lipoprotein"
                     /protein_id="WP_001254601.1"
                     /translation="MRRSGSKLCLIAMITATATLTACAPKGSVEQHTRHYVYASDDGFD
                     PNFSTQKADTTRMMVPFFRQFWDMGAKDKATGKSRSDVQQRIQQFHSQEFLNSLQGTTQ
                     FAGTDYRSKDLTPKKSRLLADTISAVYLDGYEGRQ"
                     /name="Exc2 family lipoprotein"
     gene            6296..7981
                     /locus_tag="KP64216c_RS00045"
     CDS             6296..7981
                     /locus_tag="KP64216c_RS00045"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin-like bacteriocin tRNase domain-containing
                     protein"
                     /protein_id="WP_004178188.1"
                     /translation="MSGGDGRGPGNSGLGHNGGQASGNVNGTSGKGGPSSGGGTDPNSG
                     PGWGTTHTPNGDIHNYNPGEFGNGGSKPGGNGGNSGNHSGSSGGGQSSATAMAFGLPAL
                     ATPGAEGLALSVSGDALSAAVADVLAALKGPFKFGLWGIAIYGVLPSEIAKDDPKMMSK
                     IVTSLPADTVTETPVSSLPLDQATVSVTKRVADIVKDERQHIAVVTGRPMSVPVVDAKP
                     TKRPGVFSVSIPGLPSLQVSVPKGVPAAKAPPKGIIAEKGDSRPAGFTAGGNSREAVIR
                     FPKESGQKPVYVSVTDVLTPAQVKQRLEEEKRRQQAWDAAHPEEGLKREYDKAKAELDA
                     EDKNIATLNSRIASTEKAIPGARAAVQEADKKVKEAEANKDDFVTYNPPHEYGSGWQDQ
                     VRYLDKDIQNQNEKLKAAQTSLNEMNESLSRDKAALSGAMESRKQKEKKAKDAENKLNE
                     EKKKPRKGTKDYGHDYFPDPKTEDIKGLGELKEGKPKTPKQGGGGKRARWYGDKKRKIY
                     EWDSQHGELEGYRASDGEHLGAFDPKTGKQVKGPDPKRNIKKYL"
                     /name="colicin-like bacteriocin tRNase domain-containing
                     protein"
     gene            7991..8248
                     /locus_tag="KP64216c_RS00050"
     CDS             7991..8248
                     /locus_tag="KP64216c_RS00050"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin immunity family protein"
                     /protein_id="WP_004152553.1"
                     /translation="MGLKLHIHWFDKKTEEFKGGEYSKDFGDDGSVIESLGMPLKDNIN
                     NGWFDVEKSWVSILQPHFKNVIDISKFDYFVSFVYRDGNW"
                     /name="cloacin immunity family protein"
     gene            8333..8482
                     /locus_tag="KP64216c_RS00055"
     CDS             8333..8482
                     /locus_tag="KP64216c_RS00055"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891188.1"
                     /GO_component="GO:0019867 - outer membrane [Evidence IEA]"
                     /GO_process="GO:0019835 - cytolysis [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin release lysis protein"
                     /protein_id="WP_004152552.1"
                     /translation="MKKVKVVFLFILIFSGFLLVACQANYIRDVQGGTVAPSSSSELTG
                     IAVQ"
                     /name="colicin release lysis protein"
     BGC             1296..9619
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          complement(8586..9164)
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="95.361"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          2634..3361
                     /name="MOBC"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="1.32e-150"
ORIGIN
        1 gacggacacc ggacgcgctg atgtggcata ttgtcccctg attaagtctt tatattccct
       61 gataataaat taccaggata ggtgaatcat atcggttttt cgctgaacat tttacgttaa
      121 cctatctctg ttgctttttt ctccttacgg agaaatacag gtcatccccg cgagggcgtg
      181 gctgacctca gggggatatc ccctgcttac gctggctgga cgccaccgac gcacggtctc
      241 tccccctctt tctggctccg tccggctgga cgccggccac gccagaaatt cacccggccc
      301 ccgtcaggct cacgcctgac cacccacaaa aatccacggt gctggacgca cctggcgaag
      361 cagcaaagct gctcctgatt ttgcgggtgg tcagccgctc gctatggcga actctgacgg
      421 gggccggaac accggaaaag accgcactgg ggtgccgcct tttcctctca cacgctgggg
      481 cgtgctcgtt gttcctccgg ggctgcgcct tttccgcatg gggcggaaag aggctggcct
      541 ccgtggtgaa agctgaacgc aatcaccacg gacgtgaccg ccgccgccat gccttggggc
      601 atgtccgcgg cttgtgcagc gggggctgca catcacgccg gcaaaccatc gtctgaagga
      661 gagagaacat gtttaatacg gattcgcttg cctggaagtg gcacattccg gagctggccc
      721 ggcagattta tccgtgggtc agctggctgt accaggagta ttacggtctg gccggggctt
      781 tcctagttat cggcctgttt ttcggtctgg ctgaactttg ggccggacgg atgcgttttg
      841 tggggctgag tcataaggag cgacgggagt atgccgatcg ctataagcgc gataataaac
      901 ggccagcgcc attttcggtg ctggcctcgc tggattcgcc cgggcggatg gtcagggcac
      961 gtcgacatgt ctggaactac gcgtactggc tgaccggcgc ggccggtctg gcccttctgg
     1021 gggggctggt tgtcgccgtg tttatcgaga gctggggaga aaccgtcctg cgtccggacc
     1081 tctacgcaaa cgcagattat tacctgctgc agccggctaa cctgttcggg attgcctggt
     1141 gcgcgggcgg gctggctgtc gggattgtgt tggcgcggct gctggcgttc ctgctgcttg
     1201 acggtcattt tgcggctgct gacgaggcgg tgaacgcgaa actgaatcag gagagccggc
     1261 gcagcagcca gcggacagga gagatgaccg acgtgcgcca cctgcatttc ggggagccgg
     1321 taccggttaa tgcgctggcc gatttttcct cggagcaggc ccggcaggag caggcggtgt
     1381 ttctgggtaa ggatgagcag ggcaagccgg tgctggttcc gcgtgatacc tggcgcaaga
     1441 ccaacattca gatcctcggc ctgcccggga gcggcaagag cgtgatggcc accaacgcgc
     1501 tcattcgctg cgtacgcgat ttcggggacg cggtggtgta cttcgacccc aaaggggacg
     1561 catgggcgcc gcacgtcttc cgggcgcact gtccggactt caccctgctg gatctgcggc
     1621 cggggaaacc ggcgcagctg aatctgttcc gcgatctcga ccagtacgcg ctgaaaaacc
     1681 tgctgattgc cgggcttaac ctgggcgaga ccggcgacgt ggcggaccac taccgcatca
     1741 gcgagcagaa agcggcgaag ctgattgcgg agcagtttcc gcagggggca aacattcagc
     1801 aggtgctggc ggcggcgtac gcgctgccgg aggccctgaa aaaggacgtg aaggggttga
     1861 tcactaggct ggaaaacgtc gctgacctga gcgtcctgca gacggacagt ggcatcgatg
     1921 tggcggggat tatcaacggc ggcggctgcc tgtacgttat cggctcgatg gacgacgagg
     1981 cggtgatccg tgtgcaaaaa atgctgtttg cccgctgcgc gcaaatcatc attgcgcggg
     2041 acgagttccg ggagtggcca cacgtcagcg tgatgctcga tgaaattaaa tatctgctgt
     2101 cgaagtatgt actgaacgca ctggggacgc tgcgcagccg ggactgcaat ctgttgctcg
     2161 cgcaccagtc gctgggcgat ttcgggcagt gcgggcagga tctgcccgct gaatttgtga
     2221 aaaccacggt actggataac acgccgatcc gctggtttta ccgggcggcc agcctggagt
     2281 ccgcgcagtg ggcggcgggg cagaccgggg aaatcagggt ggacgtggag cgccgccgtg
     2341 ccagccggga ggcggggaac gtggagcata tcagcgggga cagcttcatc cagaaggagg
     2401 cgcggccgct gtttgacgtg aacaccctgc aacacctgcc ggacgggttc gcggtcatga
     2461 ccgggctggg tgtggcccgg atggcgttca gcagtccgct gcgggttgag cgccgggaaa
     2521 tcccgttgca gcgtttcccg gtgctggcga aaaccgatcc cctggcggag ttccggcccc
     2581 cggccgacgg cggcgggccg aaagcggatg atgattttgc ggggatttac tgatggcgct
     2641 ggagctgtac aacgtcagcc acgcgaaacg acaggcgcgg aacgcggaga aaacccggct
     2701 gaccctgcgc tggttgcggg aagagctgtg ttccacggcg gagctggttg cgcggcggct
     2761 ggggattgcg gcggtgcagc cggtctaccg cttcctcgac agcctggtgg cgaaagggct
     2821 gctggtccgg accaaatatc cggtggacgg ccgtcaggtc agcgtgtggg ggctgacgcc
     2881 gcatggcgtg gcgttctcgt tcgacgagga cgaaccgctg gcggatgtta ttccgtttca
     2941 gccgtcaagg gtgtcggcag cacatctgcc gcaccggctg gccgtgcaat ccctgcgcct
     3001 tgatatggaa gccagagggg ccaccggctg gcgcattctg caccgtctga gtcttaaagg
     3061 catgaaagtg ccggacgccc tggcggagct ggacggtaaa acggtggcgt ttgaggtgga
     3121 gcgcaccgtc aagagccgtc gccggtatca ggaagtggtg tccgggtatc tgttcaaccg
     3181 caaagctaac ggcatcgatg aaatctggta catctgcccg gaccgggcga cgcaggtcag
     3241 ggtgcagcgg gcaatcctgt cggtggatga aatcgtgaac ccacagaccg gcgaggcccg
     3301 caaaacggca gagctggatc gtgaacggtt gtttgcgtgc tttaaattta tgacaacgga
     3361 gtgagggatt atggcgctgt acatggtatt tattgaagac gcggaggacc ggaacggcga
     3421 gcgctgcatc atgccgacca gcgagcatct ggaagatatg gtggtgctcg cctggcagac
     3481 cggggcgtat gttttctgtt ttgtcgaccg ggcccagcat ctggcgatga tgaaatccat
     3541 cgggatgtat gacgagcggc tcaacagcga cgaaaaagcc acgtactttt tcactggtaa
     3601 aaatccgcaa tgggaacgga acaaacccac aggaatgaag ctgtgtgatt acctctatcg
     3661 caaggtggag cggttcgcca tcgagaacgg tgtgcaggtg gttgatgccg ggaagtgctc
     3721 accggagcag attaacgcga tgattgacgt ggtgagtgag cggcacgggg aaagcgcggt
     3781 gaacgagaag ctgaaagcgg agctgatgcg ggaatataac agccgctatt ttaacgtgcc
     3841 ggtacctgaa ctgccggagg acaaacctgc ccgccggtgg tggccgttcg gcaaaaaata
     3901 aatgccagca ccggccatgc cggtgctgtt attcctcccc gagcttatcc cgcatcacct
     3961 gccagagtgt ttccgcatcc tcgtgtagcc gctcgcacat gtcggccggg gtatccatat
     4021 ccagctcatt cagtttatcg agcaatagca gcgactgctc cttaataaat ttagccatat
     4081 tgagggctgt tttttcctgt tttgtcatga ttctttcctt ccgggcatgg tgtgcgcctg
     4141 tcaggtatac tgtctcaaaa atagcggggt gagacaatgg cgtgggtgac ggtgagacag
     4201 gcgacggaac tgacgggtaa agcccgaagt tccctgtatc gggatatggc gaaaggccgc
     4261 gtatcatacc gtacggaagc tgatggcggc cgggtggtgg ataccagcga gcttatccgg
     4321 gtgtacggtg agttaagaca ggatgagact cacgagcggg acgagttgag actgtcgggt
     4381 gagactgaaa aaatggcctc cgacgcgttg atcgcggaga taaaagcact cagggaggag
     4441 gtggccgggc tacggcagga aatgcagtcc atgagactgc tggaacacaa accggagaca
     4501 gcagagaccc cggccggaac accgcgccgg tggtggccgt ggggaaaacg ctgacgcgct
     4561 gtgcttgtcc aaccggcgac ggccacgcaa tgaattgcgt ccccgtcacc ggttattaga
     4621 gaacaatatg gggattctgg cgctggccga ccacggccag aacccggact tttctggtct
     4681 ggtcatcaac atcatagagg acatgctgtc ccatcagact gatccggcga acgtcctcgc
     4741 catagcgtga gtccacttca tagagtcgcg ggaagtcggc cagtttgtcc gccgcagcga
     4801 gaacccggtc ggtaacgttc tgcgcatccc acagggatga attttccgcg atatagtcaa
     4861 acagcgtcgt tacatcctcg atggctccct gcttccattc cacgtcatac ggcatcgcgc
     4921 agttcctgat aacggccatg caggcgctgg cggagttgtt ccgtggtcat acccggacgc
     4981 gtgtcagcac gggcggcggt cactttggcg cgaacctgat cttcatactc tgcctgggcc
     5041 agttcttcgt tagccagtcg ctgcaacagc gcagctttgt ccgggccacc ttccggcagt
     5101 atgcggggca ggctttcagc cagttcccga agaaagttgg cgttttcgta gtgtgtagtg
     5161 ttgctcattg cggagcctcc cgggttaatg cggcaatatg aaggaagttt agcagggggc
     5221 ggtctgaaag aatatggtcg tgtcagtcag gctgatgaag cagaaagtcg gtaaaaaagg
     5281 gcttacggca tccattttac gtcaaaacat atgccatgca gttgcgtgca taggcatgca
     5341 ttaggataaa atttatcggg cgcgtttccg gcagttttcc gggggggttg ttgcctgttt
     5401 tatcccgtag ccgccggaaa cgccctgagc ccgtctgagc ggtgcgcgta atgacgcgtt
     5461 atggtaaatc cacttactgt ctgccttcat agccatcgag ataaacagct gaaatggtgt
     5521 cagccagtag ccttgatttt ttcggtgtga ggtctttgct gcggtaatcg gtacccgcaa
     5581 attgtgttgt gccttggagt gagtttaaaa attcctgact gtgaaactgc tgaatgcgtt
     5641 gctgcacatc actccgtgat tttccggtcg ctttatcctt tgcgcccata tcccagaact
     5701 gccggaaaaa aggcaccatc attcgtgttg tgtcagcttt ctgggtggaa aaattgggat
     5761 caaaaccgtc atctgaagca tatacgtaat gccgggtatg ctgttccacg ctgccctttg
     5821 gagcacaggc agtgagagtt gctgtcgctg ttatcatggc gataagacac agtttgctgc
     5881 cggaacgtct catgagcgtc tccttacctt taattctttt ttctcattga gttatatatc
     5941 cgcaggctat cttatcatca gtttctgacc gtgttcagtg accgaacaac ccgaaccaga
     6001 ccccccgttt cttttcctgt cccggagggg gctttctggt atctcatata atgatttcag
     6061 taaaacatac tgaggccgga gaacggcgcc gtttgtgctg gtttttgttg catctggagg
     6121 ggattgcgca tggtgtgagt ggctgttttt ttgatcattt tcacaaaaac gcaaatttac
     6181 agacttgaca tgaaaaacaa ggcagcgtaa tttttatact gtatataaaa ccagtggtta
     6241 tatgtacagt attttatttt agtttattgt tttaaaagtc aaagaggaaa agtatatgag
     6301 tggcggagac ggacgaggtc cgggtaattc aggtctggga cacaatggtg gtcaggccag
     6361 tgggaatgtg aacggtacat caggtaaagg tggcccttca tcaggtggtg gtacggatcc
     6421 aaacagcggg ccgggctggg gtacgacgca tacacctaac ggggatattc ataactataa
     6481 cccgggggag tttggtaacg gcgggagtaa acccggtggt aatggcggta acagcggcaa
     6541 tcatagcggg agctctggtg gcggacagtc ttcggccacc gcgatggcct tcggtctgcc
     6601 tgccttggcc actccggggg ctgaaggact ggctttatcc gtttccggcg atgcgttgtc
     6661 ggccgctgtt gctgatgtgc tggctgccct gaaaggtccg tttaagtttg gtctgtgggg
     6721 gattgcgatt tacggagtgc tgccttctga gatagcaaaa gatgatccga aaatgatgtc
     6781 aaaaatcgtg acgtcattgc cggcagacac ggtaacggag acgccggtca gctccctgcc
     6841 gctggaccag gcgacggtca gcgtcactaa acgtgtggcg gatattgtga aggacgagcg
     6901 gcagcatatt gcggttgtca ccggccggcc aatgagtgtt cctgtggtgg atgcgaaacc
     6961 gacaaaacgt ccgggggtat tcagtgtgtc gattccgggt ctcccgtctc tgcaggtgag
     7021 cgtacctaaa ggtgttccgg ccgcgaaagc cccgccaaaa ggcattattg ctgaaaaagg
     7081 tgattcacgt ccggctggtt ttacggccgg tggtaactcc cgtgaagccg ttattcgttt
     7141 cccgaaagag agcggacaga aaccggtcta tgtgtcggtg acggatgttc ttactccggc
     7201 acaggtaaaa cagcgtctgg aggaagaaaa gcgtcgccag caggcatggg acgctgctca
     7261 cccggaagag gggctgaaaa gagagtatga taaagcgaaa gctgagctgg atgctgaaga
     7321 taaaaatatt gcgaccttaa acagtcgcat tgcatcgaca gagaaggcga tccccggtgc
     7381 aagggctgct gttcaggaag ccgataaaaa ggtaaaagag gcagaggcaa ataaagatga
     7441 ttttgtgact tataacccgc ctcatgaata tggctccggg tggcaggatc aggttcgcta
     7501 tcttgataag gatattcaga atcagaatga gaaattaaaa gctgcccaga catctttaaa
     7561 cgaaatgaat gaatccttat ccagggataa ggctgcgctt tccggggcga tggagagccg
     7621 gaaacaaaag gagaaaaaag cgaaggatgc agaaaataaa ttaaatgagg aaaagaaaaa
     7681 acctcgtaag ggaactaaag attacggcca tgattatttt cctgatccca agactgaaga
     7741 tattaagggg ttgggagagt tgaaagaggg taaacctaaa acccctaaac aaggtggtgg
     7801 tggtaagcgg gcccgatggt atggtgataa aaagcgtaaa atttatgaat gggattccca
     7861 gcacggtgag cttgaagggt accgcgccag tgatggcgaa cacctcgggg cattcgatcc
     7921 aaaaacgggt aagcaggtta aagggccgga tccaaaacga aacattaaaa aatatcttta
     7981 agaggtaaat atggggctta aattacatat tcattggttt gataagaaaa ccgaagagtt
     8041 taaaggtggt gaatactcaa aagacttcgg tgatgatggt tctgtcattg aaagtctggg
     8101 gatgccttta aaggataata ttaataatgg ttggtttgat gttgaaaaat catgggtttc
     8161 gatattacag ccacacttta aaaatgtaat cgatattagt aaatttgatt actttgtatc
     8221 ctttgtttac cgggatggta actggtaagc aaaagttatc aaggatgatt tgaaatacag
     8281 acttccggtg ttcagggatg aataccgggg tttttaaata cagggaaggt atatgaaaaa
     8341 ggtaaaggtt gtttttcttt ttatattgat tttttcaggc tttcttctgg tcgcatgtca
     8401 ggcaaactat atccgggatg ttcagggtgg aacggtggca ccatcgtcct cctctgaact
     8461 gacggggatc gcggttcagt agaaaagatc aaaggatctt cttgagatcc tttttttctg
     8521 cgcgtaatct tttgccctgt aaacgaaaaa accacctggg gaggtggttt gatcgaaggt
     8581 taagtcagtt ggggaactgc ttaaccgtgg taactggctt tcgcagagca cagcaaccaa
     8641 atctgtcctt ccagtgtagc cggactttgg cgcacacttc aagagcaacc gcgtgtttag
     8701 ctaaacaaat cctctgcgaa ctcccagtta ccaatggctg ctgccagtgg cgttttgcgt
     8761 gcttttccgg gttggactca agtgaacagt taccggataa ggcgcagcag tcgggctgaa
     8821 cggggggttc ttgcttacag cccagcttgg agcgaacgac ctacaccgag ccgagatacc
     8881 agagtgtgag ctatgagaaa gcgccacact tcccgcaagg gagaaaggcg gaacaggtat
     8941 ccgggaaacg gcagggttgg aacaggagag cgcaagaggg agcgattcat cggaaacggt
     9001 gatgatcttt aagtcctgtc gggtttcgcc actcctgact gattcatggt tgagccaccg
     9061 gctcccacag atgcaccgaa aaagcgtctg tttatgtgaa ctcagtcagg agggcggagc
     9121 ctatggaaaa acgccacctg cgtggccttg ccgttttgcc tcacatgtta gtcccctgct
     9181 tattcacgga atctgtgggt aactttgcat gtgtccgcag cgcccgccgc agtctcacgg
     9241 ccggagcgta gcgaccgagt gagcgaggag gcgcaatttc cccggcacct acaagacgga
     9301 caccggacgc gctgatgtgg catattgtcc cctgattaag tctttatatt ccctgataat
     9361 aaattaccag gataggtgaa tcatatcggt ttttcgctga acattttacg ttaacctatc
     9421 tctgttgctt ttttctcctt acggagaaat acaggtcatc cccgcgaggg cgtggctgac
     9481 ctcaggggga tatcccctgc ttacgctggc tggacgccac cgacgcacgg tctctccccc
     9541 tctttctggc tccgtccggc tggacgccgg ccacgccaga aattcacccg gcccccgtca
     9601 ggctcacgcc tgaccaccc
//
