LOCUS       NZ_LR135342            28557 bp    DNA     linear   CON 13-FEB-2024
DEFINITION  Enterococcus faecium isolate E7356 plasmid 4.
ACCESSION   NZ_LR135342
VERSION     NZ_LR135342.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMEA4885156
            Assembly: GCF_900639505.1
KEYWORDS    RefSeq.
SOURCE      Enterococcus faecium
  ORGANISM  Enterococcus faecium
            Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
            Enterococcus.
REFERENCE   1  (bases 1 to 28557)
  AUTHORS   Arredondo-Alonso,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-DEC-2018) UNIVERSITY MEDICAL CENTER UTRECHT,
            Heidelberglaan 100, 3584 CX Utrecht, Netherlands
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/13/2024 03:09:00
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,192
            CDSs (total)                      :: 3,101
            Genes (coding)                    :: 2,974
            CDSs (with protein)               :: 2,974
            Genes (RNA)                       :: 91
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 127
            CDSs (without protein)            :: 127
            Pseudo Genes (ambiguous residues) :: 0 of 127
            Pseudo Genes (frameshifted)       :: 54 of 127
            Pseudo Genes (incomplete)         :: 74 of 127
            Pseudo Genes (internal stop)      :: 29 of 127
            Pseudo Genes (multiple problems)  :: 26 of 127
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LR135342.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..28557
                     /organism="Enterococcus faecium"
                     /mol_type="genomic DNA"
                     /isolate="E7356"
                     /db_xref="taxon:1352"
                     /plasmid="4"
     gene            complement(<1..259)
                     /gene="prgO"
                     /locus_tag="EQB70_RS16445"
     CDS             complement(<1..259)
                     /gene="prgO"
                     /locus_tag="EQB70_RS16445"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001196543.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA segregation protein PrgO"
                     /protein_id="WP_077150518.1"
                     /translation="MALLPTNKDKKKIGAEDISIKDDINVELGERKYTAKERKPVQVDP
                     PVLKTIRDLSYAKDIPMYEIVKLAMDAYVDTLNDEERIIYN"
                     /name="prgO"
     gene            complement(231..1184)
                     /locus_tag="EQB70_RS16450"
     CDS             complement(231..1184)
                     /locus_tag="EQB70_RS16450"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016623100.1"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ParA family protein"
                     /protein_id="WP_000429439.1"
                     /translation="MENLRTAFKTSDKLGKVVMLTGRKGGIGKTTDNDLLAIVSSQLFE
                     KDVLLIDYDQQRNTTSNIGSTYQITSFDRSMSAAIKKGDWVSGITQVSPHLYIMAGSPG
                     SEELNEYLSEKYPDRRKRSLAFIKPLEELRKNFDYIFIDCPPSTDNVVRAFLTAADYII
                     AMQELKRYAMEGTEDFINKVLVPIVTNFEESHLQIIGILPVLFSVRRSSQHANYQKTID
                     KYGESNIFKSIVKGSDRLEMYGENGIQLNDYVDRRWWAIFADIFTELEERIEYYEQHGD
                     IEGFDYTPKYADSMANHILPLGKEIKLNGIITNEQR"
                     /name="ParA family protein"
     gene            1796..3289
                     /locus_tag="EQB70_RS16455"
     CDS             1796..3289
                     /locus_tag="EQB70_RS16455"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000947690.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="primase C-terminal domain-containing protein"
                     /protein_id="WP_000947691.1"
                     /translation="MLSEIYSAILKNGLRTYKYRNSTMKPAGHIDSSRSGAIFAYRSKQ
                     LMNVGRGMVITSEEAILENEKKLTHWTPNTYRFGTYADDYRTVVKGHSEKNLSQINTFV
                     VDIDSKENHQGEIILACLDQVGYMPTLILESDHGYQVYFVLKTPGYVTKKSNFKVIDVA
                     KKISKTIRLQLAEKLSGVDLGCNHFGIARFPQENNIVFKEMNYQYSFADWIQWSMKLES
                     DQKTKEDRERKLIVFPEKKEIRQVDEPWFDMLLHKANIVGGEGRLGRNNVIFTLSLAYY
                     SSGYALDTCEYNMFTFNERLQEPLSEAELVKIVRSAYSGNYQAASREFIIELCQQWVSP
                     TLKNNDLFIQRRGWWKFKKPRDQRKYSHKNEWKEDLLAYLSEKSLASEPYLNLSKKELA
                     SQLTMPKRTLDKILNELREENKVFYKVTRGRNGGMIIASVKTLFARVIQLSKEKRLDYS
                     TRITEVFGLNESLVEETFRQLSTPLNPLKEVNLFEVDTG"
                     /name="primase C-terminal domain-containing protein"
     gene            3424..3720
                     /locus_tag="EQB70_RS16460"
     CDS             3424..3720
                     /locus_tag="EQB70_RS16460"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000053907.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication control protein PrgN"
                     /protein_id="WP_000053907.1"
                     /translation="MSLKNYVYSHPVNVFIIGRLGLSVEVFCELYGFKQGTLSSWVTRE
                     KTVASLPIEFLHGLSLASGETMDQVYDCLCVLEQEYIEYKIANELRKRKKYIQ"
                     /name="replication control protein PrgN"
     gene            3821..4672
                     /locus_tag="EQB70_RS16465"
     CDS             3821..4672
                     /locus_tag="EQB70_RS16465"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002338002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002287227.1"
                     /translation="MKSDDWIEHTWLPLKRNSKRKKFWVLQLWPLGKLCSYGARLILDL
                     TVYSIGVFGTAYYLINDPNRIAASDIFTVLMTLIFVMLLSIFTQLVMQFTRQKLTAGKL
                     FKSLFDLIVVNAILATLIKQIEQSGRTTKGVKDFLLTFIHFVNGHMYLFEVGIILFFVG
                     YVSTKLIKRSIEKEIEIDLIPTLLGYEYNVDFGRYDELINTDIVHTSIHESTVKGIRSI
                     LKNGQEMKAIDRRKEIYNFYEVEASLRYGIGKLWLDGSNIRQNKPYIFWNSSDLELPMK
                     DK"
                     /name="hypothetical protein"
     gene            4693..4905
                     /locus_tag="EQB70_RS16470"
     CDS             4693..4905
                     /locus_tag="EQB70_RS16470"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002324171.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002324171.1"
                     /translation="MIPLYRIVLIVGMELKTLKKEQLFKVKERHNQLLCSKTGTMNIEY
                     RTEYLELTNQTDFLLIRKQQEQEKN"
                     /name="hypothetical protein"
     gene            5338..6018
                     /locus_tag="EQB70_RS16475"
     CDS             5338..6018
                     /locus_tag="EQB70_RS16475"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="WP_001067799.1"
                     /translation="MNPFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            6199..7158
                     /locus_tag="EQB70_RS16480"
     CDS             6199..7158
                     /locus_tag="EQB70_RS16480"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000221326.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS30-like element IS6770 family transposase"
                     /protein_id="WP_002324287.1"
                     /translation="MTYKHLTIDELTMIESYYLQHNKPVEIANRMGRAIQTIYNVVNKF
                     KQGKTALDYWHQYKENKKKCGRKVIQLPAHEVDYIKEKVTLGWTPDVIIGRKERSVSCG
                     MRTLYRLFSKGIFDIDTLPMRGKRKPNGHQEKRGKQQYQRSIHDRSDNYPDFNSEFGHL
                     EGDTIVGIHHKSAVITLVERLSKVIITIKPNGRKALDIETALNQWFSRFPKNFFKSITF
                     DCGKEFSNWKAISNQHDIDIYFADPGTPSQRPLNENSNGILRRNGLPKSMDFRKVNQTF
                     ISSVSNQRNHIPRKSLNYRTPIEIFLSYVQEAFYSSLI"
                     /name="IS30-like element IS6770 family transposase"
     gene            7480..7650
                     /locus_tag="EQB70_RS16900"
     CDS             7480..7650
                     /locus_tag="EQB70_RS16900"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000713595.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000713595.1"
                     /translation="MKKFIYRVLENDEVVAIFNEQQYAQDFIAYEKTISDKQFEIEKVD
                     IADWLLQPREF"
                     /name="hypothetical protein"
     gene            7664..8266
                     /locus_tag="EQB70_RS16485"
     CDS             7664..8266
                     /locus_tag="EQB70_RS16485"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002333458.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_001062586.1"
                     /translation="MAKIGYARVSSKEQNLDRQLKALEGVSKVFSDKLSGQSVERPQLQ
                     AMLNYIREGDIVVVTELDRLGRNNKELTELMNQIQIKGATLEVLNLPSMNGIEDENLRR
                     LINNLVIELYKYQAESERKRIKERQAQGIEIAKKKGKFKGRQPKFKENDPRLQHAFDLF
                     LNGCSDKEVEEQTGINRRTFRRYRSRYNVTVDQRKKQ"
                     /name="recombinase family protein"
     gene            8282..>8959
                     /locus_tag="EQB70_RS16490"
                     /pseudo=""
     CDS             8282..>8959
                     /locus_tag="EQB70_RS16490"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000108743.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003916 - DNA topoisomerase activity [Evidence IEA]"
                     /GO_process="GO:0006265 - DNA topological change [Evidence
                     IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="DNA topoisomerase"
                     /name="DNA topoisomerase"
     gene            9270..9767
                     /locus_tag="EQB70_RS17140"
     CDS             9270..9767
                     /locus_tag="EQB70_RS17140"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA recombinase"
                     /protein_id="WP_002327635.1"
                     /translation="MLFLRDGEIKATLTTMMNKLAFSHKLILEPLFKSVSQIDEESDRE
                     RMDAIDKLMEQLLEERNTLIALMSKGFLEPALFNQERNVLDSEIKNLTTEKTNLVTNSA
                     SGVLRANEIKDLINYVSADNFNGDYTEELFEEFVVNIIVNSRDELTFNLKCGLSLKEKV
                     VR"
                     /name="DNA recombinase"
     gene            9768..10184
                     /locus_tag="EQB70_RS16500"
     CDS             9768..10184
                     /locus_tag="EQB70_RS16500"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000323438.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase"
                     /protein_id="WP_000323438.1"
                     /translation="MAYIPYGYKIQDGVVTVDEKAAGQVKVFFEKYISGLSLTVAGEQA
                     GIEKTHSVMGRILKNVNYLGNDTYPAIIDKEIFDKAEEVRDKRAKDLGRVVELAAFTSP
                     PPKERFKMKKADNKMPVDPFERAEYLYSLIESEE"
                     /name="recombinase"
     gene            10186..11748
                     /locus_tag="EQB70_RS16505"
     CDS             10186..11748
                     /locus_tag="EQB70_RS16505"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000136908.1"
                     /GO_function="GO:0000150 - DNA strand exchange activity
                     [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_000136908.1"
                     /translation="MTEKNIMVIPARKRVGSTAAKEKIKKLRVAAYCRVSTETEEQNSS
                     YEVQVSHYTEFIKKNNEWEFAGIFADDGISGTNTKKRDEFNRMIAECMDGNIDMVITKS
                     ISRFARNTLDCLQYIRQLKDKNISVYFEKENINTTDAKGEVLLTIMASLAQQESQSLSQ
                     NVKLGLQYRYQQGKVQVNHKRFMGYTKDEDGNLTIVPEEAEIIKRIYREYLEGQSLVGI
                     GRALEKDGILTAAGKPRWRPESVKKILQNEKYIGDALLQKTVTVDFLTKKRVKNEGHVP
                     QYYVENSHEAIIPKELFLQAQEEIHRRSNIYTGEGKNKRIYSSKYALSAITFCGDCGDI
                     YRRVYWNIHGRKEFVWRCVTRIEQGPEVCKNRTVKEDELYGAVMTAINKLLAGGNNMIK
                     TLEENIHAVIGETTEYQISEINNSLEEKQKELIKLANKGQDYDHLADEIDELRDKRQIL
                     LVEDASLSGENERINELIEFIRKNKFRTLEYDDKLVRKIIQSVTVYEGHFVIAFKSGIE
                     MEI"
                     /name="recombinase family protein"
     gene            11891..12115
                     /locus_tag="EQB70_RS16510"
     CDS             11891..12115
                     /locus_tag="EQB70_RS16510"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018579902.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_000205227.1"
                     /translation="MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDE
                     LKAIADVLGVKFVQAFILPDGEEIKISNE"
                     /name="helix-turn-helix transcriptional regulator"
     gene            12130..12999
                     /locus_tag="EQB70_RS16515"
     CDS             12130..12999
                     /locus_tag="EQB70_RS16515"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002328890.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotidyltransferase domain-containing protein"
                     /protein_id="WP_060763469.1"
                     /translation="MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYY
                     NSDSFDLTAINQIATELDDENRNNLVVPPGAWGDWVNGGGWLVINGCHVDLILRDIKRV
                     EQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIYPTA
                     LKKSLMNFFIFEAEFSLMFVKANAGAEDKYYIAGHVFRIISCLNQVLFACNNAYCINEK
                     KAIKLLETFEYKPEKYAERVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEE
                     SSDERKQI"
                     /name="nucleotidyltransferase domain-containing protein"
     gene            12980..13714
                     /locus_tag="EQB70_RS16520"
     CDS             12980..13714
                     /locus_tag="EQB70_RS16520"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016250180.1"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]; GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_000662263.1"
                     /translation="MKENKYDDNIFFQKYSQMSRSQKGLAGAGEWETLKKMLPDFKGKR
                     VLDLGCGYGWHCIYAMENGASSVVGVDISHKMLEVAKGKTHFPQIEYECCAIEDVDFPE
                     ESFDVILSSLAFHYVADYENLIKKIYRMLKAGGNLVFTVEHPVFTAHGTQDWYYNEKGE
                     ILHFPVDNYYYEGKRTAMFLEEKVTKYHRTLTTYLNTLLSNSFIINQIVEPQPPENMMD
                     IPGMADEMRRPMMLIVSAKKKM"
                     /name="class I SAM-dependent methyltransferase"
     gene            13747..14655
                     /locus_tag="EQB70_RS16525"
     CDS             13747..14655
                     /locus_tag="EQB70_RS16525"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032491779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminoglycoside nucleotidyltransferase ANT(6)-Ia"
                     /protein_id="WP_001255866.1"
                     /translation="MRSEKEMMDLVLSLAEQDERIRIVTLEGSRANINIPKDEFQDYDI
                     TYFVSDIEPFISNDDWLNQFGNIIMMQKPEDMELFPPEEKGFSYLMLFDDYNKIDLTLL
                     PLEELDNYLKGDKLIKVLIDKDCRIKRDIVPTDIDYHVRKPSAREYDDCCNEFWNVTPY
                     VIKGLCRKEILFAIDHFNQIVRHELLRMISWKVGIETGFKLSVGKNYKFIERYISEDLW
                     EKLLSTYRMDSYENIWEALFLCHQLFRAVSGEVAERLHYAYPEYDRNITKYTRDMYKKY
                     TGKTGCLDSTYAADIEERREQ"
                     /name="aminoglycoside nucleotidyltransferase ANT(6)-Ia"
     gene            14652..15194
                     /gene="sat4"
                     /locus_tag="EQB70_RS16530"
     ARG             14653..15191
                     /name="sat4"
                     /gene="sat4"
                     /gene_name="streptothricin N-acetyltransferase Sat4"
                     /tool="amrfinderplus"
                     /drug_class="STREPTOTHRICIN"
                     /identity="100.0"
                     /coverage="100.0"
     gene            15287..16081
                     /gene="aph(3')-IIIa"
                     /locus_tag="EQB70_RS16535"
     ARG             15288..16078
                     /name="aph(3')-IIIa"
                     /gene="aph(3')-IIIa"
                     /gene_name="aminoglycoside O-phosphotransferase
                     APH(3')-IIIa"
                     /tool="amrfinderplus"
                     /drug_class="AMINOGLYCOSIDE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            16357..>16488
                     /locus_tag="EQB70_RS17300"
                     /pseudo=""
     CDS             16357..>16488
                     /locus_tag="EQB70_RS17300"
                     /inference="COORDINATES: protein motif:HMM:NF024804.4"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="HTH domain-containing protein"
                     /name="HTH domain-containing protein"
     gene            16660..>17057
                     /locus_tag="EQB70_RS17305"
                     /pseudo=""
     CDS             16660..>17057
                     /locus_tag="EQB70_RS17305"
                     /inference="COORDINATES: protein motif:HMM:NF024676.4"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="WYL domain-containing protein"
                     /name="WYL domain-containing protein"
     gene            17227..18123
                     /locus_tag="EQB70_RS16555"
     CDS             17227..18123
                     /locus_tag="EQB70_RS16555"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002355409.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="WP_002334978.1"
                     /translation="MIQYYYTKKEWGVVMEKEKLKILEELRRILNNKNEAIIILNNYFK
                     GGVGKSKLSTMFAYLTDKLNLKVLMIDKDLQATLTKDLAKTFEVELPRVNFYEGLKNGN
                     LASSIIHLTDNLDLIPGTFDLMLLPKLTRSWTFENESRLLATLLAPLKSDYDLIIIDTV
                     PTPSVYTNNAIVASDYVMIPLQAEEESTNNIQNYISYLIDLQEQFNPGLDMIGFVPYLV
                     DTDSATIKSNLEELYKEHKEDNLVFRNIIKRSNKVSTWSKNGITEHKGYDKKVLSMYEN
                     VFFEMIERIIQLENEKE"
                     /name="AAA family ATPase"
     gene            18222..18431
                     /locus_tag="EQB70_RS16560"
     CDS             18222..18431
                     /locus_tag="EQB70_RS16560"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000527318.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="peptide-binding protein"
                     /protein_id="WP_000527318.1"
                     /translation="MGNLGAQKAKRNDTPISAKKDIMGDKTVRVRADLHHIIKIETAKN
                     GGNVKEVMDQALEEYIRKYLPDKL"
                     /name="peptide-binding protein"
     gene            18448..18720
                     /locus_tag="EQB70_RS16565"
     CDS             18448..18720
                     /locus_tag="EQB70_RS16565"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002333002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="antitoxin"
                     /protein_id="WP_002331065.1"
                     /translation="MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVN
                     LLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYSKQILNKEKVA"
                     /name="antitoxin"
     gene            18722..19585
                     /locus_tag="EQB70_RS16570"
     CDS             18722..19585
                     /locus_tag="EQB70_RS16570"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010782381.1"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA];
                     GO:0016301 - kinase activity [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zeta toxin family protein"
                     /protein_id="WP_074394525.1"
                     /translation="MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSG
                     KTSLRSAIFEETQGNVIVIDNDTFKQQHPNFDELVKLYEKDVVKHVTPYSNRMTEALIS
                     RLSDQGYNLVIEGTGRTTDVPIQTATMLQSKGYETKIYVMAVPKIESYLGTIERYETMY
                     ADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISP
                     KETLERELNRKVSGKEIQPTLERIEQKMVQNQHQETPEFKAIQQKMESLQLPTPPIPKT
                     PKLPGI"
                     /name="zeta toxin family protein"
     gene            complement(19848..20585)
                     /gene="erm(B)"
                     /locus_tag="EQB70_RS16575"
     ARG             complement(19852..20585)
                     /name="erm(B)"
                     /gene="erm(B)"
                     /gene_name="23S rRNA (adenine(2058)-N(6))-methyltransferase
                     Erm(B)"
                     /tool="amrfinderplus"
                     /drug_class="LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(20710..20793)
                     /locus_tag="EQB70_RS16580"
     CDS             complement(20710..20793)
                     /locus_tag="EQB70_RS16580"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001814874.1"
                     /GO_process="GO:0046677 - response to antibiotic [Evidence
                     IEA]; GO:0031556 - transcriptional attenuation by ribosome
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA methyltransferase attenuation leader
                     peptide"
                     /protein_id="WP_001814874.1"
                     /translation="MLVFQMRNVDKTSTVLKQTKNSDYADK"
                     /name="23S rRNA methyltransferase attenuation leader
                     peptide"
     gene            20940..21620
                     /locus_tag="EQB70_RS16585"
     CDS             20940..21620
                     /locus_tag="EQB70_RS16585"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="WP_001067799.1"
                     /translation="MNPFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            <21672..22241
                     /locus_tag="EQB70_RS16590"
                     /pseudo=""
     CDS             <21672..22241
                     /locus_tag="EQB70_RS16590"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010769338.1"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="FtsX-like permease family protein"
                     /name="FtsX-like permease family protein"
     gene            22642..23247
                     /locus_tag="EQB70_RS16595"
     CDS             22642..23247
                     /locus_tag="EQB70_RS16595"
                     /EC_number="2.7.7.108"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016176895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protein adenylyltransferase Fic"
                     /protein_id="WP_000599739.1"
                     /translation="MILENKLGLTNQVELAKVEEKLSKQKAKELYDCGKINEIEVGTFK
                     GLSEIHEFLFSDIYDFAGKIRSVNIAKGNFRFAPVMYLEHSLQHIDQMPQTSFEEIIKK
                     YVEMNIAHPFREGNGRSTRIWLDLILKEELQKVVDWNLIDKADYLSAMERSPINDLEIR
                     YLISNALTDKIDDRELYMKGIDVSYFYEGYSEYTIDDL"
                     /name="protein adenylyltransferase Fic"
     gene            23263..23835
                     /locus_tag="EQB70_RS16600"
     CDS             23263..23835
                     /locus_tag="EQB70_RS16600"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000170424.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_000170424.1"
                     /translation="MTKYGYARVSTASQSTKEQIQQLLENGVEKKNIFSEKFTGTKRDR
                     PKFNQLLAGLKPGDEIVVTKLDRFARNTREALEIIEPLLDDNVTIKVLNLGTIENTSMG
                     RMVTRTLLSVAEMERDMIVERTQEGKMFARKNNPNFREGRPKATITPKKRHAYELLTSG
                     KSYKEVEAITGFSRSTLFRIKKKIEES"
                     /name="recombinase family protein"
     gene            complement(24087..24344)
                     /locus_tag="EQB70_RS16605"
     CDS             complement(24087..24344)
                     /locus_tag="EQB70_RS16605"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002326781.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002326781.1"
                     /translation="MANLYIENKGDLNAIITLIVVMVKSIGNITIGMLFIILAAVLIFM
                     IVIWFLNERSKDNQHRRDMEIKSIESIDYLSIITLKKPRS"
                     /name="hypothetical protein"
     gene            complement(24470..25285)
                     /locus_tag="EQB70_RS16610"
     CDS             complement(24470..25285)
                     /locus_tag="EQB70_RS16610"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002326780.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_002326780.1"
                     /translation="MVKIAGLSKGGKTVSQLYKQNYRDWRQFRKNIKDSYFILPTELEK
                     YLPNNKAINLYLYYCFKAKNEGGDSWHSVNTIAESLGVTTKTINTWNKTLVDLGMIARI
                     DDNHLSKSTILLPLSSYYKLALDSSLKDVTESTVHEIDGNLVAVYHLFEWRKNEADENY
                     NVPYNTLCCVFKRKTQKDTIYKFILVQDEKISNFELSTPSSKIYDDAYRFECQDLEALL
                     SANNLNNIEHENFVVNTRFNLVSEKDSDLLDLLIELTKNLDKKENITVL"
                     /name="helix-turn-helix domain-containing protein"
     gene            25802..27127
                     /locus_tag="EQB70_RS16615"
     CDS             25802..27127
                     /locus_tag="EQB70_RS16615"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002335330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Y-family DNA polymerase"
                     /protein_id="WP_002342448.1"
                     /translation="MMDYSKEPVNDYFLIDMKSFYASVECIERNLDPLTTELVVMSRAD
                     NTGSGLILASSPAAKKKYGISNVSRPRDLPQPFPKTLHVVPPRMNLYIKRNMQVNNIFR
                     RYVADEDLLIYSIDESILKVTRSMNLFTTEGTRSQRRKKLAQMIQENIKEELGLLATVG
                     VGDNPLLAKLALDNEAKHNDGFLAEWTYQNVPDKVWNIPEMTDLWGIGSRMKKRLNQIG
                     IMSIKDLANWNPYTIKSHLGVIGLQLYFHANGIDRTDIAIPPEPTKEKSYGNSQVLPRD
                     YTRRNEIELVVKEMAEQVAIRIRQHNCKTGCVHLYIGTSILETRPGFSHQMKIPITDNT
                     KELQNYCLFLFDKYYEGQEVRHVGITYSKLVYTDSLQLDLFSDPQKQIDEENLDKIIDK
                     IRQKYGFTSIVHASSMLEGARSITRSTLVGGHAGGAGGLKND"
                     /name="Y-family DNA polymerase"
     gene            27120..27470
                     /locus_tag="EQB70_RS16620"
     CDS             27120..27470
                     /locus_tag="EQB70_RS16620"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002359653.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002326767.1"
                     /translation="MIDYNDRGRLKWAGFYLSDHTEKIDADNEQRANQNLAKEQMTTEE
                     VAEVLNAAVIKNRSVCIQKEERNAEGYYPEDIVSKILGSDELGIYVGKNKVHYDEIRHI
                     EFYQDNKWGRLE"
                     /name="hypothetical protein"
     gene            27467..27637
                     /locus_tag="EQB70_RS16625"
     CDS             27467..27637
                     /locus_tag="EQB70_RS16625"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016631600.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_073490843.1"
                     /translation="MNIIQQYELKYITFDQLSEEIWGYGQRLINEVGVERFSFYVEAAA
                     GYHKYEYYIGY"
                     /name="hypothetical protein"
     ARG             13748..14652
                     /name="ant(6)-Ia"
                     /gene="ant(6)-Ia"
                     /gene_name="aminoglycoside nucleotidyltransferase
                     ANT(6)-Ia"
                     /tool="amrfinderplus"
                     /drug_class="AMINOGLYCOSIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             complement(19849..20585)
                     /name="ErmB"
                     /gene="ErmB"
                     /gene_name="Erm 23S ribosomal RNA methyltransferase"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic; lincosamide antibiotic;
                     streptogramin antibiotic; streptogramin A antibiotic;
                     streptogramin B antibiotic"
                     /identity="98.37"
                     /coverage="98.79"
     ARG             14653..15194
                     /name="SAT-4"
                     /gene="SAT-4"
                     /gene_name="streptothricin acetyltransferase (SAT)"
                     /tool="rgi"
                     /drug_class="nucleoside antibiotic"
                     /identity="99.44"
                     /coverage="100.0"
     ARG             13748..14655
                     /name="aad(6)"
                     /gene="aad(6)"
                     /gene_name="ANT(6)"
                     /tool="rgi"
                     /drug_class="aminoglycoside antibiotic"
                     /identity="100.0"
                     /coverage="109.42"
     Typing          1797..3289
                     /name="rep_cluster_185"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.866"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 tattatatat aatccgttcc tcgtcgttta aagtatcaac ataggcgtcc attgcaagtt
       61 tgactatttc atacatagga atatcttttg cataactaag atcccgaatg gtttttagta
      121 cgggaggatc tacttgaact ggttttcttt ctttcgcagt gtactttcgt tcccctaact
      181 cgacattaat atcatcttta attgaaatat cttcagcacc aattttcttc ttatctttgt
      241 tcgttggtaa taatgccatt tagtttaatc tcctttccaa gaggtaggat atgattggcc
      301 attgagtcag catatttagg tgtataatca aatccttcaa tatcaccatg ttgttcatag
      361 tattcaattc tttcttctaa ttctgtaaag atgtctgcaa aaatagccca ccatcttcga
      421 tctacataat catttaattg gataccattc tcaccataca tttctaaccg atccgagcct
      481 ttaacaatgc ttttaaaaat gtttgattca ccatacttat caattgtttt ttgatagttt
      541 gcgtgttgag aggaacgtcg cactgagaaa agaacaggca aaattccaat gatttgaaga
      601 tgagactctt caaaattcgt gacaatcgga actaaaactt tattaataaa atcttctgtt
      661 ccttccattg cgtaccgttt taattcttgc attgcaataa tataatctgc agcagttaag
      721 aatgcacgaa ccacattatc tgttgatggt gggcagtcga taaagatata atcgaaattt
      781 tttctcaatt cttctaaagg tttaatgaag gccaatgatc tcttacgacg atcaggatat
      841 ttttcggaca agtattcatt aagttcttca gatccaggag agccagccat aatatataaa
      901 tgtggactta cttgagtaat acctgaaacc cagtcccctt ttttgattgc tgcagacatg
      961 gatcgatcaa agctagtaat ttgatacgtt gatccaatgt tggaagtagt atttctttgt
     1021 tggtcataat caattagcaa cacgtctttt tcaaaaagtt gactagaaac aatcgctaat
     1081 aaatcattgt ctgtagtctt accaatgccg ccttttctac ctgtaagcat tacaactttt
     1141 cctagtttat ctgatgtttt aaatgcagtc cgtaagtttt ccatagttcc ctccaatttc
     1201 ctatactaaa tatatttagt atacttcata tacttaatat attcgatata tctaatatac
     1261 tccaaattga taagaattca gactttataa ggaatatagt ggatatacta aatatatttg
     1321 ctatattcag tatatcagat atattcaaaa tgtcaaaata tatttgtgcg ttttgcgttg
     1381 acaatttaga gtgaaaagag gtaaacttaa ttctatagaa accacagata attcactatt
     1441 tacaaagtag caaaagcagt ggtactcttt aaacagaaaa attacataaa aaaaagagac
     1501 ggaaataatt gattttagca gaatcaatta tttctgaatc acatggttag gacatgtgtt
     1561 cacgctcgtc tcaagaatat gtaagtagct accaactact tatattaaaa gttgatcgga
     1621 taccttttcc gattgccttt attctaccaa aaaaaggcga gcaactcaac agaagaacgt
     1681 ttatttagtg tacttaaatt aaatattctt aaacactgaa gagagaacac atactatggc
     1741 tgagattaaa gctaaactgt gttctctttt tgtttgagaa aggacgttac aatcgatgtt
     1801 gagcgaaatt tattcagcta ttcttaaaaa cggcttacgt acatacaaat atcgaaacag
     1861 caccatgaaa cctgcaggtc atattgattc cagtaggagt ggtgctatct ttgcgtaccg
     1921 tagcaagcaa ttaatgaatg ttgggcgtgg tatggtcatt acttcggaag aagctatttt
     1981 agagaacgaa aagaaactaa cgcattggac acctaatacc tatcgctttg gtacttatgc
     2041 ggatgattat cgaacagtgg ttaaaggtca ttctgagaaa aacttaagtc aaatcaacac
     2101 atttgtagtt gatatcgatt caaaagagaa ccatcaaggc gaaattattt tagcctgttt
     2161 agatcaagtg ggctacatgc caacgctaat tttagaatca gatcatggtt atcaagttta
     2221 ttttgtacta aagacaccag gctatgtcac aaagaaaagc aatttcaagg tgatcgatgt
     2281 agcaaaaaaa atttcaaaaa caattcgtct acagttggct gaaaaattgt ccggagtgga
     2341 tctaggatgt aaccacttcg gaattgctcg attcccacaa gaaaataata ttgtttttaa
     2401 agaaatgaac tatcagtatt cttttgctga ctggattcaa tggtcgatga agcttgaatc
     2461 agatcaaaaa acaaaagaag atcgagaacg aaaactaatt gtctttcctg agaaaaaaga
     2521 aattcgtcaa gtagatgaac cgtggttcga tatgttactt cataaagcaa acatcgtcgg
     2581 cggagaagga cgtcttggtc gaaataatgt gattttcacg ctttctttag cttattactc
     2641 ttcaggttat gcattggata cttgcgaata caatatgttc acattcaacg aacggttaca
     2701 ggaaccgcta tctgaagcag aattagtaaa gattgtacgt agtgcttatt ctggtaatta
     2761 tcaagcagca agcagagaat tcattattga attgtgccag caatgggttt caccaacctt
     2821 aaaaaataat gatctgttca ttcaacgacg tggctggtgg aaatttaaaa agccacgaga
     2881 tcaaagaaaa tatagtcata aaaatgaatg gaaagaagat ctattggctt atctaagcga
     2941 aaaaagtctt gctagtgagc cttatttgaa cctgtcaaaa aaagaattgg cttcacaact
     3001 aacgatgccc aagcgaacac ttgataagat cttaaatgag ttacgagagg agaataaagt
     3061 cttctacaag gtaacacgag gaagaaatgg cggaatgatc attgcttcag tcaaaacgtt
     3121 gttcgcgagg gttattcaac taagtaaaga aaagagacta gattattcaa caaggatcac
     3181 agaggtattt ggactcaacg agagcttagt agaagagaca tttagacaat tatcaacccc
     3241 cttgaaccct cttaaagaag tgaatctttt tgaagtagat acaggttgaa aaataaaagg
     3301 tgcaaattgc cttatacaat atatctatga tacttctgta ggtgttgctc cctttgccta
     3361 gctacgtgta ggtggtatac ttataactgc gtatgcagtc ttatgtatca tggaggaagt
     3421 tgtatgtcgt taaaaaatta tgtctattca catcctgtta atgtgtttat cattggtcgt
     3481 ttgggattat ctgtggaagt gttctgtgag ctttatggtt ttaagcaggg gactttgtct
     3541 tcttgggtta ccagggaaaa aacagttgct tctttgccga ttgagtttct tcatgggttg
     3601 tccttagctt ctggggagac tatggatcag gtatatgatt gtttgtgtgt gttagagcag
     3661 gagtatattg agtataaaat agctaacgag ttaagaaaaa ggaagaagta tatccagtag
     3721 tagtttttat ttacttaaaa aattggttca ttgagcaacc tatcgctgct aaagtagcaa
     3781 aggaaaacgt taaaggaaag aatttaggga agaaatcgaa atgaaatcgg acgactggat
     3841 tgaacacacc tggcttcctc tgaaaagaaa tagcaaacga aagaaatttt gggtattgca
     3901 attatggcca ttaggaaaac tttgtagtta cggggcacga cttattcttg atttaaccgt
     3961 ttactcgatt ggagtatttg gaacggctta ttacttgata aatgatccca ataggattgc
     4021 agcatcagac atttttacag tgctaatgac gttgattttt gtcatgctat tgtctatttt
     4081 tactcaatta gtcatgcaat ttaccaggca aaaattaaca gcaggaaaac ttttcaaaag
     4141 cctattcgat ttaattgttg taaatgcaat tctagcgact ttaataaaac aaattgaaca
     4201 atctggaaga acaacaaaag gagtgaagga ttttttattg acgtttattc actttgtaaa
     4261 tggacacatg tatttgtttg aagtgggtat tattctcttt tttgtcgggt atgtatccac
     4321 gaaacttatt aaacgttcaa ttgaaaaaga aattgaaatt gacctgattc cgacacttct
     4381 tggttatgag tacaatgttg attttggaag atatgacgaa ttgatcaata cggatatcgt
     4441 tcacacgagt atccatgaat ctactgttaa gggcatcaga tctattttaa aaaatggcca
     4501 ggaaatgaaa gcaatagatc gaagaaaaga gatctacaat ttttatgaag tcgaagcaag
     4561 cctacgatat ggcatcggaa aattgtggtt agatggaagt aatattcgtc aaaacaaacc
     4621 atacattttt tggaacagta gtgatttaga acttccaatg aaagataaat aattatggag
     4681 aatcgtttga aaatgattcc tctatacagg attgtgctta tagttggcat ggagttaaaa
     4741 accttaaaga aggagcagtt attcaaagtg aaagaacgtc ataatcagtt actatgtagt
     4801 aaaacgggta cgatgaacat tgaataccga acagaatatt tagaattaac gaatcaaact
     4861 gattttttgt tgattcgaaa gcaacaagag caagaaaaaa attaatggct acttatagcc
     4921 aattgattga tgaatgggaa caattcaagg aatctaaaat tccagaacgt ctctaaaagc
     4981 ctttatttgt aaagagcata aggaaacgtg ggaacacttt ttaaaaaaag tgttccaata
     5041 ggctgtgcct attacgtttc tcaaaaataa atgtgggaac aaaatattta aaaataggat
     5101 agtgaaagga tagtgaagga tagtaaaagg agggtagtag gatagcaaaa aggataggct
     5161 ccttttcgct atccttttta aattggagga attaatatgg aagtaagaat aagaaatgtg
     5221 gatgagaaaa tcgtaagaga aattgatcga agatgtgacg aacggttctg ttgcaaagtt
     5281 ttaaatctac tatcaaataa ggtagaataa tagaaaaaga tagcaggagg aatgacgatg
     5341 aatcctttta aaggaaagca atttcagcag gatgtgatta ttgtagccgt gggctactat
     5401 cttcgttata accttagcta tcgtgaagtt caagaaatct tatatgatcg tggcattaac
     5461 gtttctcata cgacgattta tcgttgggtg caagaatatg gcaaactact ctatcaaatt
     5521 tggaaaaaga aaaataaaaa atccttttat tcatggaaaa tggatgaaac gtacatcaaa
     5581 attaaaggaa aatggcatta tttgtatcga gccatcgatg cagatggttt aaccttggat
     5641 atttggttac gtaaaaaacg ggacacacaa gcagcctatg cttttcttaa gcggttagtg
     5701 aagcagtttg atgaaccgaa ggttgtagtc acagataaag ccccctctat tacaagtgcc
     5761 tttaagaaac taaaagaata cggcttttat caaggaacag aacatcgtac cattaaatac
     5821 ctgaataatt tgattgaaca agaccatcgt ccagtaaaga gacgcaataa attctatcga
     5881 agtttacgca ctgcctctac cacgattaaa ggcatggaag ccattcgagg attatataag
     5941 aaaacccgaa aagaaggcac tctcttcggg ttttcggtct gtactgaaat caaggtatta
     6001 ttgggaatcc cagcttaaat catagatacc gtaagggatt ttattcttta tttaaaactt
     6061 tgcaacagaa ccacccgcac tatgccatta catttatatc tacgcgaatt gtaaaattaa
     6121 gttagaaaaa taaaaaggca tttatggtac actcaaattg tatttccgac gaaagaaaac
     6181 aaaggagtgt aaccataaat gacctacaaa catcttacca tagacgaact gacaatgata
     6241 gaatcatatt atcttcaaca taataagccg gttgaaatcg ctaaccgaat gggacgtgct
     6301 atacaaacta tttataatgt agtcaataag ttcaagcaag gcaagactgc tcttgattat
     6361 tggcaccagt ataaagaaaa taagaaaaaa tgtggtagaa aagtcattca attacctgct
     6421 catgaagtag attacattaa agagaaagtc actcttggtt ggacgcctga cgtcattatc
     6481 gggcgaaaag aaaggtctgt ttcatgcggt atgagaacac tttatcgttt attttctaaa
     6541 ggaatatttg atattgacac actaccgatg agaggtaaaa gaaaacccaa tggccatcag
     6601 gaaaaacggg gaaaacaaca gtatcagcgc tcaatccatg atcgatctga taattatcct
     6661 gatttcaatt ctgagtttgg tcaccttgaa ggtgatacga tcgttggcat tcatcataaa
     6721 agtgccgtca ttactttagt tgaaagatta tctaaagtca ttatcacgat taaacccaac
     6781 ggccgtaagg cattagatat tgaaactgcc cttaatcaat ggttttctcg cttccctaaa
     6841 aacttcttta aatctattac gtttgactgt ggaaaagaat tttctaactg gaaagccatt
     6901 agtaaccaac atgatattga tatatatttt gcggaccctg gaacaccttc tcaacgccca
     6961 ttaaacgaga attctaacgg gattctgcgt cgtaatggac tgccgaaatc aatggatttt
     7021 agaaaagtga atcagacatt tatttccagt gtcagcaatc aacgtaatca tattccaaga
     7081 aaatcattga attacagaac accaatcgaa atatttttga gctatgtaca agaagcattt
     7141 tattctagct taatttgaca aatcatacta tgatacgtgt ttgtttttct gtgctgttta
     7201 gtgaatgatt agcagaaata tagagagtaa gattttaatt aattattagg gggagaagga
     7261 gagagtagcc cgaaaacttt tagttggctt ggactgaacg aagtgaggga aaggctacta
     7321 aaacgtcgag gggcagtgag agcgaagcga acacttgatc ttttaagttg ctatcttttt
     7381 aaggtcaata gagtatactt atttgtccta atatggtttt agcagtataa ttgacttggt
     7441 gaataggtca tttaagttgg gcataatagg aggagtaaaa tgaaaaaatt tatttatcga
     7501 gttttagaaa atgacgaagt ggtggctatt tttaatgagc aacaatatgc gcaagatttt
     7561 atcgcttacg aaaagacaat ttctgataag caatttgaaa ttgaaaaagt agatatagct
     7621 gattggttat tgcaaccgag agaattttag aggttggttg aaaatggcta aaattggtta
     7681 tgcacgtgtc agtagcaaag aacagaactt agatagacaa ctgaaagcgt tagagggcgt
     7741 ttctaaggtc ttttcagaca aattaagcgg tcaatcggtc gaacgcccac aattacaagc
     7801 tatgcttaac tatattcgtg aaggggatat agttgttgtt actgaattag atcgattagg
     7861 acgaaataat aaagaattaa cagaattgat gaatcaaatt caaattaagg gggcaaccct
     7921 ggaagtctta aatttaccct caatgaatgg tattgaagat gaaaatttaa gacggctgat
     7981 taataattta gtgattgaat tgtataagta ccaagcggaa tctgaacgca aacgaattaa
     8041 agaacgccaa gcccaaggaa ttgaaattgc taagaaaaaa ggaaaattca aagggcgaca
     8101 acctaaattc aaagaaaatg atccacgttt acaacacgct ttcgatttat ttttgaatgg
     8161 ttgttccgat aaagaagttg aagaacaaac tggaattaat cgccgaacgt ttagaaggta
     8221 tcgatcaaga tacaacgtga cagtagatca aagaaaaaaa caatgaaaag agggatagtt
     8281 aatgagtacg gttattttag ctgaaaaacc aagccaggca ttagcctacg caagtgcttt
     8341 aaaacaaagc accaaaaaag acggttattt tgagatcaaa gacccactat ttacagatga
     8401 aacgtttatc acctttggtt ttgggcattt agtcgaatta gcagaaccag gtcattataa
     8461 cgaaaagtgg cagaactgga aacttgaatc tttgccgatt tttcctgatc gatacgattt
     8521 tgaagttgca aaagataagg gaaagcagtt taaaattgtt gctgaacttc tcaaaaaggc
     8581 aaatacaatt attgtcgcaa cagatagcga cagagaaggt gaaaatatcg cctggtcgat
     8641 tatccataaa gcaaatgcct tttctaaaga taaaacgtat aaaagattat ggatcaatag
     8701 cttagaaaaa gatgtgatcc gaagcggttt tcaaaatttg caaccaggaa tgaattacta
     8761 tcccttttat caagaagcgc aaacacgcca aattgccgat tggttgatcg gcatgaacgc
     8821 aagcccttta tataccttga atttacaaca aaaaggcgta caaggtacat tttcattagg
     8881 acgtgtacaa acaccgactt tatatctcat ttatcaacgc caggaagcaa tagaaaactt
     8941 taaaaaagaa ccttttttcc tgaataattc atagttttac taatagtctt tcctaacatt
     9001 gatttaatag tctttaaagt attctgcttc atcacccatt aggtgatgaa aaaagaaccc
     9061 ctttctgatt tagcggacaa atactttgac ctaatctcag aagatataaa agaaaaaata
     9121 ataaaatatc cgatttatac tttgtataaa gaactaaagt agttagcaaa tcatttacag
     9181 caaatcacta tgttccacat accattttac atacttacct tatccacgac acatgttgag
     9241 atagtatcga agataaagaa agttgctcca tgttgttttt gcgagatggg gaaatcaaag
     9301 ccacattgac aaccatgatg aataagcttg ctttcagtca taagctaatc ctagaaccac
     9361 ttttcaagtc agttagccaa atcgatgaag aaagcgaccg tgaaagaatg gacgctattg
     9421 ataagctaat ggagcaacta ttggaagaac gcaataccct tattgcactg atgtccaaag
     9481 gtttcctaga acctgctctt tttaatcagg aacgaaatgt tttagatagt gagattaaaa
     9541 atcttactac cgaaaaaaca aacctggtaa cgaactctgc gagtggggtt ttgcgagcaa
     9601 acgagataaa ggacctcatt aattatgtgt cagcagataa ttttaatggt gactacacgg
     9661 aagaactatt tgaagaattt gtagtgaaca tcattgtaaa ttccagggat gagctgacat
     9721 tcaatttgaa atgcggtctt tccctgaaag aaaaggtggt gagataaatg gcatatattc
     9781 catatggata caaaattcaa gatggagtgg ttactgtcga tgaaaaggca gcaggtcaag
     9841 taaaggtatt ctttgagaaa tacatatcag gactatccct tacagtggct ggcgaacagg
     9901 caggtattga aaagacacat tctgtgatgg ggcgcatttt gaaaaacgtc aactaccttg
     9961 gaaatgatac gtatccagca attattgata aagagatatt tgataaagct gaagaagtta
    10021 gagataaacg tgcaaaggat ttaggacgag tggtagagct tgccgctttc acctctcccc
    10081 ctcccaaaga acgattcaaa atgaaaaagg cagataataa gatgccagtg gatccttttg
    10141 aacgagcaga atacttatac agtctgatag aaagcgagga ataaagtgac agagaaaaat
    10201 ataatggtta ttcctgctcg taaaagagta ggaagtacag ccgcaaaaga aaagataaag
    10261 aaacttcgtg ttgctgccta ttgccgtgtt tctacagaaa cagaagaaca aaattctagc
    10321 tatgaggttc aggtctcaca ctatacagag tttataaaga aaaataatga atgggagttt
    10381 gctggcatct ttgcagatga tggtatctct ggtacgaaca ctaaaaagcg tgacgaattt
    10441 aatcgcatga ttgcagagtg tatggacggt aacatcgaca tggttattac aaaatccatc
    10501 agccgatttg cgcgtaacac cctagactgc cttcaataca ttagacagct caaggataag
    10561 aacatatcag tttattttga gaaagagaac atcaacacca cggatgccaa aggtgaggtt
    10621 ttgctgacta ttatggcatc tttggcacag caggaaagcc agagcctttc acaaaacgtt
    10681 aagcttgggc tacagtaccg ataccaacaa ggaaaggtgc aggtcaacca taagcgattt
    10741 atgggctaca cgaaagatga agatggaaat ttaactattg tccccgaaga agctgagatt
    10801 atcaaacgca tctaccgaga ataccttgag ggtcagagtc tagtgggcat tggtcgagcc
    10861 cttgaaaagg atggtatttt aacagcagcg ggaaaaccaa gatggcgacc agaatcagtt
    10921 aagaagatac ttcaaaacga aaaatacatc ggagatgccc ttctgcaaaa gactgtcaca
    10981 gtagattttc tgaccaagaa acgagtgaaa aatgaagggc atgttcccca atattatgtt
    11041 gaaaatagcc atgaagcgat tattcctaaa gagttatttt tgcaggcgca agaagaaatt
    11101 catcggagaa gcaatatcta cacaggagaa ggcaagaaca aaagaattta cagtagcaag
    11161 tacgctttaa gtgccatcac cttctgtgga gattgtggcg atatttatag acgggtctat
    11221 tggaatatcc acggaagaaa agaatttgtc tggcgatgcg tgactagaat cgagcaaggt
    11281 cctgaagttt gtaagaaccg aaccgtaaaa gaagatgaac tttatggtgc agtaatgact
    11341 gcgattaata agctacttgc aggtgggaac aatatgataa agacactgga agagaatatt
    11401 catgctgtga ttggcgaaac cacagaatac caaatttcag agattaacaa ctcactagag
    11461 gaaaaacaaa aagaactaat caagctggcg aacaagggtc aagactatga ccacttagca
    11521 gatgagattg atgagctgag agacaagcga cagatccttt tagtagaaga tgcctccctc
    11581 agtggcgaga acgagcgaat caatgagctg attgaattta tccgcaagaa caaattccgc
    11641 accttagaat atgatgataa gcttgtaagg aagataatcc agagcgttac agtctatgaa
    11701 ggccacttcg tcatagcctt caaatctggc atcgaaatgg aaatatgaaa accagaagta
    11761 aatagcccat gactctacag tagagttgtg ggttttcttt tgcttgctga ttataataat
    11821 attttaataa ctattgtgtt tatcaaccaa atggtttata atattcttag cgtaaacttg
    11881 gaggtgctgt atgactacgg cagaaatgat taaagaactg tgtgagcaaa tgaatataag
    11941 tgtttccgaa cttgctagac gtattggcca gactccacag aatttcaata aaaaattaca
    12001 acgagaaaca gtaaccttgg atgagttgaa ggccattgct gatgtgctag gtgtcaagtt
    12061 tgtgcaggca tttattttac cagatggaga agaaataaaa atatctaacg aataaaggag
    12121 gatgtttata tggtaggtaa tgttattcaa atagtaacag agaaattatc atctttgcct
    12181 tttatagaag gcatcgtatt agggggctca cgtgcaagag gcacccatac agaaaattct
    12241 gatatagata tcggaatcta ttacaattca gactcatttg acctgacagc gattaatcaa
    12301 attgctacag agttggatga tgagaataga aacaaccttg ttgtacctcc cggagcgtgg
    12361 ggtgattggg ttaatggcgg tggatggtta gttataaacg ggtgtcatgt tgacttgata
    12421 ttacgtgata taaaacgggt ggaacaaata atcaaagata cggagcaagg aattgttact
    12481 gccaattatc agaccgggca tccccatggt tatataagtg ctatgtatcg tggagaatta
    12541 gcgattagta aaatactata tgctaagaac gaaagcttat gcgaattaaa aaagcaggca
    12601 gaaatttacc ctactgctct aaagaaaagc ttgatgaact tttttatatt tgaagctgaa
    12661 ttctctttaa tgtttgtaaa agcaaatgcg ggggcagagg ataaatatta tattgcaggc
    12721 catgtttttc gtattatttc atgcttaaat caagtactat ttgcatgtaa taatgcttat
    12781 tgcattaacg aaaagaaagc tataaaactg cttgaaactt ttgaatataa acctgaaaaa
    12841 tatgccgaaa gagttaatca tatttttgaa gtactcggtc tttctctttt tgaatgctac
    12901 gacatgaccg agaaacttta taaagaagtg aatgaaattg tatcggagat aaataacttt
    12961 ttaaacgagg agagttcaga tgaaagaaaa caaatatgat gataatatat tttttcaaaa
    13021 atacagtcaa atgagtcgct cgcagaaagg actggctggt gcgggagaat gggagacttt
    13081 gaaaaagatg ctacctgatt ttaagggtaa gcgtgtgctt gatttaggat gcggctatgg
    13141 atggcactgt atatatgcga tggaaaacgg tgcttcctct gtagtaggtg ttgatatttc
    13201 tcataaaatg ctcgaagtag caaaaggaaa aacccatttt ccacagattg aatatgaatg
    13261 ctgtgccata gaagatgtgg atttcccaga ggagagcttt gatgtaatac taagttcgct
    13321 tgcgtttcat tatgtagcag actatgagaa tttaataaaa aagatatata ggatgctgaa
    13381 ggctggtggc aatttagttt ttacagttga acatcctgtt tttactgctc atggaacaca
    13441 agactggtat tataacgaaa aaggagaaat actgcatttc ccggtggaca attattatta
    13501 tgagggcaaa cggacagcta tgtttttgga agaaaaggtt acaaaatatc atagaacact
    13561 gaccacatat ctaaatacac tgctttcaaa tagttttata ataaatcaga ttgtggagcc
    13621 acagccgcca gagaacatga tggatattcc ggggatggcg gatgaaatgc gacgcccaat
    13681 gatgctgatt gtatcggcaa aaaagaagat gtaataatat agaaaaaata aacgaggagt
    13741 atgtaaatga gatcagaaaa agaaatgatg gatttagtac tttctttagc agaacaggat
    13801 gaacgtattc gaattgtgac ccttgagggg tcacgcgcaa atattaatat acctaaagat
    13861 gaatttcagg attatgatat tacatatttt gtaagtgata tagaaccgtt tatatctaat
    13921 gatgactggc ttaatcaatt tgggaatata ataatgatgc aaaagccgga ggatatggaa
    13981 ttattcccac ctgaagaaaa gggattttcc tatcttatgc tatttgatga ttacaataaa
    14041 attgatctta ccttattgcc cttggaagag ttagataatt acctaaaggg cgataaatta
    14101 ataaaggttc taattgataa agattgtaga attaaaaggg acatagttcc gactgatata
    14161 gattatcatg taagaaagcc aagcgcaagg gagtatgatg attgctgcaa tgaattttgg
    14221 aatgtaacac cttatgttat taaaggattg tgccgtaagg aaattttatt tgctattgat
    14281 cattttaatc agattgttcg ccatgagctg ctgagaatga tatcatggaa ggtcggcatc
    14341 gaaacaggct ttaaattaag tgtaggcaag aactataagt ttattgaaag gtatatatcc
    14401 gaggatttgt gggagaaact tttgtccacc taccggatgg attcctatga aaacatatgg
    14461 gaagcattat ttctatgcca tcaattgttc agggcggtat ccggtgaggt ggcggaaagg
    14521 cttcattatg cctatccgga gtatgatagg aatataacaa aatataccag ggacatgtat
    14581 aaaaaataca ctggtaaaac cggctgcctg gatagcacat atgccgctga tatagaagag
    14641 aggcgggaac agtgattaca gaaatgaaag cagggcacct gaaagatatc gataaaccca
    14701 gcgaaccatt tgaggtgata ggtaagatta taccgaggta tgaaaacgag aattggacct
    14761 ttacagaatt actctatgaa gcgccatatt taaaaagcta ccaagacgaa gaggatgaag
    14821 aggatgagga ggcagattgc cttgaatata ttgacaatac tgataagata atatatcttt
    14881 actaccaaga cgataaatgc gtcggaaaag ttaaactgcg aaaaaattgg aaccggtacg
    14941 cttatataga agatatcgcc gtatgtaagg atttcagggg gcaaggcata ggcagcgcgc
    15001 ttatcaatat atctatagaa tgggcaaagc ataaaaactt gcatggacta atgcttgaaa
    15061 cccaggacaa taaccttata gcttgtaaat tctatcataa ttgtggtttc aaaatcggct
    15121 ccgtcgatac tatgttatac gccaactttg aaaacaactt tgaaaaagct gttttctggt
    15181 atttaaggtt ttagaatgca aggaacagtg aattggagtt cgtcttgtta taattagctt
    15241 cttggggtat ctttaaatac tgtagaaaag aggaaggaaa taataaatgg ctaaaatgag
    15301 aatatcaccg gaattgaaaa aactgatcga aaaataccgc tgcgtaaaag atacggaagg
    15361 aatgtctcct gctaaggtat ataagctggt gggagaaaat gaaaacctat atttaaaaat
    15421 gacggacagc cggtataaag ggaccaccta tgatgtggaa cgggaaaagg acatgatgct
    15481 atggctggaa ggaaagctgc ctgttccaaa ggtcctgcac tttgaacggc atgatggctg
    15541 gagcaatctg ctcatgagtg aggccgatgg cgtcctttgc tcggaagagt atgaagatga
    15601 acaaagccct gaaaagatta tcgagctgta tgcggagtgc atcaggctct ttcactccat
    15661 cgacatatcg gattgtccct atacgaatag cttagacagc cgcttagccg aattggatta
    15721 cttactgaat aacgatctgg ccgatgtgga ttgcgaaaac tgggaagaag acactccatt
    15781 taaagatccg cgcgagctgt atgatttttt aaagacggaa aagcccgaag aggaacttgt
    15841 cttttcccac ggcgacctgg gagacagcaa catctttgtg aaagatggca aagtaagtgg
    15901 ctttattgat cttgggagaa gcggcagggc ggacaagtgg tatgacattg ccttctgcgt
    15961 ccggtcgatc agggaggata tcggggaaga acagtatgtc gagctatttt ttgacttact
    16021 ggggatcaag cctgattggg agaaaataaa atattatatt ttactggatg aattgtttta
    16081 gtacctagat ttagatgtct aaaaagcttt aactacaagc tttttagaca tctaatcttt
    16141 tctgaagtac atccgcaact gtccatactc tgatgtttta tatcttttct aaaagttcgc
    16201 tagatagagt tctatattag agatgtaaag agttttggtg aagaggtttg tgagtatggc
    16261 ttttataacc agggtgcaat gagaagcact aacagcagct agcttaagaa cgcataggat
    16321 atacttttta tggaagtcac agaggaggaa taaaatttga acaggattaa cagagtaacc
    16381 tctattctta ttcagctgca atcaaaaaaa ataattcctg ccaaagaaat tgcacagcga
    16441 tttaatataa gcttaaggac agtttacaga gatatccgga cacttgaaga agccggaata
    16501 ccaattggat ctgaggccgg aaaaggatat tttcttgtag agggcttcct acttccgccg
    16561 gtaatgttta cagcggcgga agtgggtgca ttgattacag cagggaaatt tttaaattgc
    16621 catggagatg aatcatttat aaaggatttt gattcagcta tgtataaaat caaatctatt
    16681 ttgaagcatg gtgaaaaaaa ctatgcacag gagttggaga acagtattaa cgtgtacagc
    16741 acatctggac agaaaaatac attggcggat aacgttattg cagcaattca gactgcaatc
    16801 tgcaataaaa gggtaatatc aattcaatat cctgcatcag gagggcaaga accggaaagc
    16861 agaatgatag agcctatatc actggggttt tatgaacaga actggtactt aatcggtttt
    16921 gcaggctaag aaatgaatat aggaattttc gtgtggatcg gattaaaagc atttgcatag
    16981 aagaagagct ctgtcaaagc catgatggct ctttggaaca aatattaaaa caaatgcttt
    17041 catataaaaa actatatgcc ctacaatgcc gttgtaaaaa ttggggaaaa gggatatatt
    17101 gattttatat ctttctcaaa ataaatataa aagcccttta aagagggctt ttatatatta
    17161 atcacaaatc acttatcaca aatcacaagt gattaatcac aaatcacttg tgatttgtga
    17221 ttcttaatga tacaatatta ctatacaaaa aaagaatggg gcgtagttat ggagaaggaa
    17281 aaactaaaaa tacttgaaga attaagacgt attttaaaca ataaaaatga agcaattatt
    17341 atcttgaata attactttaa aggtggtgtt ggaaagtcca aattatcgac tatgtttgct
    17401 tacttgacag acaaattgaa tttaaaagtt ttaatgatcg ataaggactt acaggcaaca
    17461 ttgacaaaag acttagcaaa aacttttgag gtagaattgc cacgtgtcaa tttttatgaa
    17521 ggcttgaaaa atggaaactt ggcttcttct attattcatt tgactgataa tttagacttg
    17581 atccctggca cgtttgattt gatgttactg ccaaaattaa ctcgctcatg gacgtttgaa
    17641 aatgaaagta gattgcttgc tactctttta gcacctttaa aaagtgacta tgatcttatt
    17701 attattgata ctgtaccaac gccaagcgtt tatacaaata atgcaatcgt ggcgagtgat
    17761 tacgttatga tccctttaca agcagaagaa gaaagtacaa acaacattca aaactatatt
    17821 tcctatttga ttgatttgca agaacagttt aaccctggac tagatatgat tggttttgtt
    17881 ccttatttag ttgatacgga cagcgcaacg ataaaatcaa acctggaaga actgtacaaa
    17941 gaacataaag aggataattt ggttttccga aatattatca agcgaagtaa taaagtaagt
    18001 acttggtcta aaaatggcat tacagaacac aaaggctatg acaaaaaagt tttgtctatg
    18061 tatgagaacg tattttttga aatgattgag cgaatcattc aattagaaaa tgaaaaagaa
    18121 tagaatcaca aatcacaagt gattaatcac aaatcacttg tgatttgtga taggtgatga
    18181 taaaataaat agtaagaaga aatagaaaga agtgagcgat cgtgggaaat ttaggcgcac
    18241 agaaagcaaa acgaaatgat acgccaatca gcgcaaaaaa agatataatg ggggataaga
    18301 cggttcgtgt tcgtgccgac ttgcaccata tcataaaaat cgaaacagca aagaatggcg
    18361 gaaacgtaaa agaagttatg gatcaagcct tagaagaata tatacggaaa tatttacctg
    18421 acaaacttta aaaggagtga aaatgaaatg gcagttacgt atgaaaaaac atttgaaatt
    18481 gaaatcatta atgagttatc ggcaagtgtt tataatcggg tattaaatta tgttttgaat
    18541 catgaactag atactaaaaa tactcgttta ctagaagtga atcttttaaa tcaattagaa
    18601 gtggcacaag aagttgattt atttcaacaa ccatttgaag aattacaagc tattcatgag
    18661 tattggcggt caatgaatca atattcaaaa caaattttga ataaagagaa agtggcttaa
    18721 catggcgaat attactgact tcaccgaaaa gcaatttgaa gatcgtttag aaaagaatgt
    18781 tgaacgacta actaaaaata gactagcggt tgaatcgcca accgcttttt tacttggtgg
    18841 gcaaccaggg tcagggaaaa ccagtttgcg atcagcaatt tttgaagaaa cacaagggaa
    18901 tgttattgtc attgataatg atacctttaa acaacagcac ccaaattttg acgaattagt
    18961 gaaactctat gaaaaagacg tagtaaaaca cgttacccct tattcgaatc gcatgacaga
    19021 agcacttatt agccgtttaa gcgatcaagg ctataattta gtgattgaag gaacaggacg
    19081 aacaacagac gttcccattc aaacagccac aatgcttcaa tctaaaggtt atgaaacaaa
    19141 aatatacgtc atggcagtac cgaaaattga atcatactta ggaacgattg aacgatatga
    19201 aaccatgtat gcagatgatc caatgacagc tagggcaaca ccaaaacaag cgcatgatat
    19261 tgttgtcaaa aacttaccga ccaatttaga aacccttcat aaaacgggct tatttagcga
    19321 tataaggctt tacaatagag aaggagtgaa actctattca agcttagaaa cgccttccat
    19381 tagtccgaaa gagaccttag aaagagaatt aaatcgtaaa gtatcaggga aagaaattca
    19441 accgactttg gagagaatag agcaaaaaat ggttcaaaat caacaccaag aaacccctga
    19501 atttaaagca attcaacaaa aaatggaaag cttgcagcta cctacaccac caatacccaa
    19561 aacacctaaa cttccaggta tttaaacctt aaaaaaggaa aagagtagtt accaaaaaac
    19621 ggtaactact ctttttttat aaaaacattt cctcatgttg gggtcccgag cgcctacgag
    19681 gaatttgtat cgataagaaa tagatttaaa aatttcgctg tttttttcta atttcatttt
    19741 gaggtgaatt aattggtagt tattagaggt gccctatacc taataattta tctacattcc
    19801 ctttagtaac gtgtaacttt ccaaatttac aaaagcgact catagaatta tttcctcccg
    19861 ttaaataata gataactatt aaaaatagac aatacttgct cataagtaac ggtacttaaa
    19921 ttgtttactt tggcgtgttt cattgcttga tgaaactgat ttttagtaaa cagttgacga
    19981 tattctcgat tgacccattt tgaaacaaag tacgtatata gcttccaata tttatctgga
    20041 acatctgtgg tatggcgggt aagttttatt aagacactgt ttacttttgg tttaggatga
    20101 aagcattccg ctggcagctt aagcaattgc tgaatcgaga cttgagtgtg caagagcaac
    20161 cctagtgttc ggtgaatatc caaggtacgc ttgtagaatc cttcttcaac aatcagatag
    20221 atgtcagacg catggctttc aaaaaccact tttttaataa tttgtgtgct taaatggtaa
    20281 ggaatattcc caacaatttt atacctctgt ttgttaggga attgaaactg tagaatatct
    20341 tggtgaatta aagtgacacg agtgttcagt tttaattttt ctgacgataa gttgaataga
    20401 tgactgtcta attcaataga cgttacctgt ttacttattt tagccagttt cgtcgttaaa
    20461 tgccctttac ctgttccaat ttcgtaaacg gtatcggttt cttttaaatt caattgtttt
    20521 attatttggt tgagtacttt ttcactcgtt aaaaagtttt gagaatattt tatatttttg
    20581 ttcatgtaat cactcctgaa gtgattacat ctataaataa atacagaagt taaacgattt
    20641 gtttgtaatt ttagttatct gtttaaaaag tcataagatt agtcactggt aggaattaat
    20701 ctaacgtatt tatttatctg cgtaatcact gtttttagtc tgtttcaaaa cggtagatgt
    20761 tttatctaca ttacgcattt ggaataccaa catgacgaat ccctccttct taattacaaa
    20821 tttttagcat ctaatttaac ttcaattcct attatacaaa attttggttc tgttgcaaag
    20881 ttttaaatct actatcaaat aaggtagaat aatagaaaaa gatagcagga ggaatgacga
    20941 tgaatccttt taaaggaaag caatttcagc aggatgtgat tattgtagcc gtgggctact
    21001 atcttcgtta taaccttagc tatcgtgaag ttcaagaaat cttatatgat cgtggcatta
    21061 acgtttctca tacgacgatt tatcgttggg tgcaagaata tggcaaacta ctctatcaaa
    21121 tttggaaaaa gaaaaataaa aaatcctttt attcatggaa aatggatgaa acgtacatca
    21181 aaattaaagg aaaatggcat tatttgtatc gagccatcga tgcagatggt ttaaccttgg
    21241 atatttggtt acgtaaaaaa cgggacacac aagcagccta tgcttttctt aagcggttag
    21301 tgaagcagtt tgatgaaccg aaggttgtag tcacagataa agccccctct attacaagtg
    21361 cctttaagaa actaaaagaa tacggctttt atcaagggac agaacatcgt accattaaat
    21421 acctgaataa tttgattgaa caagaccatc gtccagtaaa gagacgcaat aaattctatc
    21481 gaagtttacg cactgcctct accacgatta aaggcatgga agccattcga ggattatata
    21541 agaaaacccg aaaagaaggc actctcttcg ggttttcggt ctgtactgaa atcaaggtat
    21601 tattgggaat cccagcttaa atcatagata ccgtaaggga ttttattctt tatttaaaac
    21661 tttgcaacag aacctattat tttaagtctg aaaaggatac atcgtctcta acgttaactt
    21721 tagaggaagg agttgaacct gacaaggtga cctctaaagt gataaaccaa ttgaaagaaa
    21781 aaggtagttt gaaacatttg ggggaatatg aagtgttaga tacggctatg ttaacgaaag
    21841 gaattggtca aatcctcagt acgatcactt attttataac agctgtagca ggtatatctt
    21901 tatttatcgc aggggtaggt gtaatgaaca tgatgtatat atctgtatct gaacgaacaa
    21961 aagagatcgg tataagaaga gccctaggag ctactcgaaa atcgattatg ctgcagttcc
    22021 ttttagaagg tttgatttta actctttcag gagggttaat tggctattta ttaggaatgg
    22081 ctcttgctta tagtgttggt tctttgataa aggtaaacgt gtcacttgat ctatttacta
    22141 ttttactagc ggttggggta tcttcggtta ttggactggt cttttctgta atgcccgctt
    22201 cagaggctgc aaaaaaagat ttaattgata ttcttagata aaatcagaat gacaagaata
    22261 tttacgttct agattctaaa ataaaacaca aagagaccaa ccaggcaccc tattgtttct
    22321 ttgtagtata gagatattct ttggcttgta agagatcaat agagttaggt gaccggagtt
    22381 cgaaataaag gaaatttttg attgtatagg agaattcttt atccctaata tttagaattt
    22441 tgagtatgcc atgttgatgt tttagattct ctataaatat agaggtgtat caaaggtcaa
    22501 ctagactgtg caaaatagag acacttgaaa aatctatcgg gggtcagaaa cttaatagtt
    22561 tttgacacat aaacaaaatc gcgatataat ggggttgaga gtgtttcata aacttatgtc
    22621 ataaagttaa ggagatttcg catgatttta gagaataaat tgggattaac caatcaagtt
    22681 gagttggcta aggttgaaga aaaactcagt aaacaaaaag cgaaagaatt gtacgattgt
    22741 ggaaaaataa atgaaatcga agttggtaca tttaaaggtt tatctgaaat tcatgaattt
    22801 ctattttcgg atatttacga ttttgccgga aaaatccgat cggtcaatat tgcaaaagga
    22861 aattttcgat ttgcaccagt tatgtattta gaacattcgt tacagcatat tgatcagatg
    22921 ccacaaactt cttttgaaga gattatcaag aaatatgtgg agatgaatat cgctcaccca
    22981 tttcgagaag gaaatggccg aagtactaga atttggctgg atctcatttt aaaggaagaa
    23041 ttgcaaaaag ttgtagattg gaacttaatc gataaagcag actatctttc tgcaatggag
    23101 cgaagtccca taaacgattt ggaaatacgc tatctaattt ccaatgctct gactgataaa
    23161 attgacgatc gcgagttata tatgaaagga atcgatgtca gctatttcta tgaagggtat
    23221 tctgagtata cgatagatga tttgtaaaag taggtggacc aaatgacgaa atatggatat
    23281 gcacgtgtct caaccgcttc tcaaagtaca aaagaacaaa ttcaacagtt gcttgagaac
    23341 ggcgtagaga agaagaatat tttttcagaa aaatttacgg gtacaaaacg ggatcggcca
    23401 aaattcaatc agctgttggc tggtctgaag cctggagatg aaatagttgt tacgaagctt
    23461 gatcgatttg ctcgtaacac gagagaagca ttagagatca ttgaaccttt actcgatgat
    23521 aacgtaacga tcaaggtttt gaatctagga acgattgaaa atacgtccat ggggcgaatg
    23581 gtgacacgga cgttgttgag tgtagcagaa atggaacgtg atatgattgt ggaacgtacc
    23641 caagaaggaa aaatgtttgc aagaaagaat aatcctaatt tcagagaagg acgtccgaaa
    23701 gcaacaatca caccgaagaa gaggcacgca tatgaactgc ttacttcagg taaatcgtat
    23761 aaggaagttg aagctataac cggtttcagt cgcagtacgc tttttagaat aaagaagaaa
    23821 attgaagaaa gttaaaaaag aagtctcagc gaaccagaca ggtaaatact taatgcgttc
    23881 tagatatgag tctattagca tgttgtgaaa tataatattt ttttatttac ttgatttctg
    23941 ctcaaaaaat gtgtatggta actgtaaaag gtaaagtaat taaaggtatg ctagccacgc
    24001 ttactatatt aggataccat catatattta taatgaacga tttgttcgtc taccaaacaa
    24061 cacatatcgt tcagcgtaag tcacgtttag gaacgtggct tttttagtgt tattatcgat
    24121 aaataatcta ttgactctat tgattttatc tccatatccc tacggtgttg attgtcttta
    24181 gatctttcat ttaagaacca aataactatc ataaaaatca gcactgctgc taatataata
    24241 aacagcattc ctattgtgat attacctatt gattttacca taactacgat taaagtaata
    24301 atggcattca agtctccttt gttctctata tataaattag ccataaatca tcttcctttc
    24361 aaattaagat acttgtttga taccaataaa tagtaagcgt ggctagcata cctttttctg
    24421 taatagcaag tgttctaata gtccaaactt aatgatggac cgatgctagt tatagtacag
    24481 taatgttttc tttcttatct agatttttag taagctctat cagcaaatct aacaaatctg
    24541 agtccttttc agaaactaaa ttaaatctag tgtttacaac aaagttttca tgttctatat
    24601 tgtttagatt atttgcggaa aggagggctt ctagatcttg acattcaaat ctatatgcat
    24661 cgtcataaat cttactagaa ggagtgctta attcgaaatt acttattttc tcatcttgga
    24721 ccaagataaa tttatagata gtatcttttt gtgtttttct tttaaaaaca caacagagtg
    24781 tgttataagg aacgttataa ttttcatcag cctcattttt tctccattca aacaaatgat
    24841 aaactgcaac caagttgcca tcaatttcat ggacagtgct ctcggtaaca tcctttaaag
    24901 aactatcaag ggctaattta tagtaactag agagaggaag taaaattgtc gatttactga
    24961 gatggttatc gtctatacgt gcaatcatac ctaaatcaac taaggtttta ttccaggtgt
    25021 ttatagtttt agttgtcact cctagagact ctgctatggt attgaccgaa tgccaggaat
    25081 ccccgccttc attctttgcc ttaaaacagt aatacagata taaattaata gctttgttat
    25141 tcggtaaata tttttcaagt tctgttggta gaataaagta agaatcctta atgttttttc
    25201 tgaactgtct ccagtctctg tagttttgtt tataaagttg tgaaacggtt tttccacctt
    25261 tagaaagtcc tgctatctta accaatctta ttgctccttt cttgaatctg tcatgatcat
    25321 acagtatttt ttacttgtag tccagcacct taatatatta tcctatgtaa ttaatttcgt
    25381 actagatagt aattattttt tatttaattc tctagtcact tacaaataag ttatataaac
    25441 tacgattaat aaattattac aaaaactatt aagaaaactt ctacatacaa ctattacaaa
    25501 actattaaga aactgaatac tcctattttt tgtttttaag gaaagttttt tcttttttga
    25561 atttcttatt tttttctaat ataactaagc aaaactggat aatacgacac ttattttcaa
    25621 attttcacaa gactaatagt aaatatccat ttaataaagt gatacaatgt gttgatttta
    25681 caaatcaaca gaagaagtag ggaaataact tacctatgct tctttttttg tacatttaat
    25741 cgattcttct ttacaaaaac gaacgtatgt ttgtataatg tggaagaatg gagtgttatt
    25801 tatgatggat tattcaaaag agccagtaaa tgattacttt ttgatcgata tgaaaagctt
    25861 ttacgcaagt gtcgaatgta tagaaaggaa tttagatcca ttaacgactg aattagtcgt
    25921 catgagtcga gcggataata caggatcagg gttgatttta gcttcttcac cagctgcaaa
    25981 gaagaagtac ggtatttcta atgtcagtcg accacgagat ctaccgcaac cttttcctaa
    26041 aacgttacat gtcgttccac cacgcatgaa tctctatatt aagcgaaata tgcaggtaaa
    26101 caatattttc agaaggtatg tagcagacga agatttattg atttactcga tcgatgaatc
    26161 gatcttaaaa gtgaccagat caatgaatct ttttacgact gaaggaacaa gaagtcaacg
    26221 gagaaagaag ctggctcaaa tgatccagga gaatattaaa gaagagctag gattgcttgc
    26281 tacagtaggt gtcggagata atcccttatt agctaaactt gctttagaca atgaagcaaa
    26341 acataatgat ggattccttg ctgaatggac gtatcaaaat gttcctgata aagtatggaa
    26401 tattcctgaa atgacagacc tttggggtat tggatctcga atgaaaaaaa gactcaacca
    26461 aattggtatc atgagtatta aagacttagc taattggaat ccatacacta ttaagagcca
    26521 tttaggtgtg attggcttac agctgtattt tcatgcgaac gggatcgatc gaacagatat
    26581 agcgatccca ccagaaccga caaaggaaaa atcatatggt aattcacaag tgttaccacg
    26641 agattatacc aggagaaatg aaatcgaact ggtggtaaaa gaaatggcgg aacaagtagc
    26701 tattcgtatc aggcaacata actgtaaaac aggttgtgtc catttataca ttggcacgtc
    26761 gatcttagaa acgagaccag gtttttcaca ccagatgaag atccctataa cagataatac
    26821 aaaggaattg cagaattact gtcttttctt gtttgataag tattatgaag gacaagaagt
    26881 aaggcacgtt ggaataacct atagcaagct tgtgtacact gattcgcttc agctggattt
    26941 atttagtgat ccacaaaagc aaattgacga agaaaattta gataaaatta ttgacaagat
    27001 tcggcaaaaa tatggtttta cgtcgattgt acatgcttct tctatgttag aaggcgctcg
    27061 tagtattact agaagtacat tggttggtgg ccatgcaggc ggcgcaggag ggcttaaaaa
    27121 tgattgatta taatgatcgt ggacgtttaa agtgggcagg tttttattta tctgatcata
    27181 ctgaaaaaat tgatgccgac aatgaacaac gagccaatca aaatttggca aaagaacaaa
    27241 tgacgactga agaggttgcg gaagtattga acgctgcagt cataaaaaat agatcagtat
    27301 gtattcaaaa agaagaacga aacgctgaag gatactatcc agaagatatt gttagcaaga
    27361 tcttaggtag tgatgagctg gggatctacg ttggaaaaaa caaagttcac tacgacgaaa
    27421 tacgtcatat cgaattttac caggataata aatggggtcg attagaatga acattatcca
    27481 gcaatatgag ctaaagtata taacctttga tcagctatca gaagagattt ggggttatgg
    27541 ccagcgtttg ataaatgagg ttggtgttga acgcttctct ttctatgtag aagctgcagc
    27601 aggataccat aaatacgaat actatattgg ctattaaagt gcaataaaat tatatttctt
    27661 ttatgtttta cattttgtat caattctgat aaaattacct ataggtaatt aaaaaatata
    27721 aaaaaactag ttacaacctt aggacgttgt aactagcttg aagcatacta gagctaacta
    27781 aaatagcact agaaagcaat gttaaacccg tccaacaaac ttgatttaac attgagacca
    27841 gcttattcag ctaaatatag ttgaataagc ttcttttgtt ttaaaaaaac aaaaggtgta
    27901 ctacgaataa cgcaagtaaa agaaatacta ttacaaccag taggctacaa gtaagtatta
    27961 ctaaacattg cgtagttaga acctttgctc tattgtctaa agccacaaaa ttagagatca
    28021 gctttatgat gctaagagcg agctgcatcc atgcggacat aggttctttt gacactatta
    28081 attctccttt ttaggataag ggaaattgct agtagttttt tcattagcac catccccctt
    28141 catttgattg agtctagtgc tgctgtgata gtttgctgtt taatatgctt acattcttat
    28201 tataacataa atgaaacaaa cacatggtta gaggtcgtat caatcaaaat agtgtctcac
    28261 aaacgattta ttacttactc ctgctgacta acggactgtt cttcagtaac tgtaactata
    28321 tgtttgttaa aaccaccatt acctgtagat aaaaaccaat atatttacta tactcactat
    28381 attaaatata tttagtatag taaaaactag aaacaataaa atttgtgaat gttgtatacc
    28441 cccaaacaat acacatattt tgaaggatta ggattaataa agctaaaaat atagtaagta
    28501 tactaaatat atttactata tctagtatac ttactatatt ttaatctttt gatcgtc
//
