LOCUS       NZ_LR135290            26053 bp    DNA     linear   CON 13-FEB-2024
DEFINITION  Enterococcus faecium isolate E7199 plasmid 4.
ACCESSION   NZ_LR135290
VERSION     NZ_LR135290.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMEA4885040
            Assembly: GCF_900639445.1
KEYWORDS    RefSeq.
SOURCE      Enterococcus faecium
  ORGANISM  Enterococcus faecium
            Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
            Enterococcus.
REFERENCE   1  (bases 1 to 26053)
  AUTHORS   Arredondo-Alonso,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-DEC-2018) UNIVERSITY MEDICAL CENTER UTRECHT,
            Heidelberglaan 100, 3584 CX Utrecht, Netherlands
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/13/2024 03:08:06
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,110
            CDSs (total)                      :: 3,018
            Genes (coding)                    :: 2,897
            CDSs (with protein)               :: 2,897
            Genes (RNA)                       :: 92
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 121
            CDSs (without protein)            :: 121
            Pseudo Genes (ambiguous residues) :: 0 of 121
            Pseudo Genes (frameshifted)       :: 43 of 121
            Pseudo Genes (incomplete)         :: 77 of 121
            Pseudo Genes (internal stop)      :: 21 of 121
            Pseudo Genes (multiple problems)  :: 17 of 121
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LR135290.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..26053
                     /organism="Enterococcus faecium"
                     /mol_type="genomic DNA"
                     /isolate="E7199"
                     /db_xref="taxon:1352"
                     /plasmid="4"
     gene            <1..1041
                     /locus_tag="EQB72_RS16040"
     CDS             <1..1041
                     /locus_tag="EQB72_RS16040"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002343466.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /protein_id="WP_000997689.1"
                     /translation="MNDFNYYKSKEIYREKYYQMPKVFFTNEKYMDLSNDAKIAYMLLK
                     DRFDYSVKNNWVDSDDNIFFIFTVEELMKLLQCREGKVSKIKKELEKAGLLKQKRGRVN
                     KRDGKIESMPNLLYLGKPEVTNQDVFKIMEEEDNTDTTVIAKIANTAKPREINDTTVIA
                     KIANTAKSSHIKDSTVIAKIADNLFYSNSIDTNRHIIDTETDQLQNQVLLDNFVDIMKE
                     DSINTFVPENVLNLIKTFSSTYEDAQKTVQTIHNAKKKAEELEQTVVVYEELESYGIDA
                     DKGLYMTLLKAYQKQKTEKVNNLQNLIFVYVKNWFVEKAIAAKLANEQRETFNELPTVS
                     TENWLE"
                     /name="replication initiator protein A"
     gene            complement(1657..2337)
                     /locus_tag="EQB72_RS16045"
     CDS             complement(1657..2337)
                     /locus_tag="EQB72_RS16045"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="WP_001015311.1"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            <2412..2600
                     /locus_tag="EQB72_RS16050"
                     /pseudo=""
     CDS             <2412..2600
                     /locus_tag="EQB72_RS16050"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000108743.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="topoisomerase C-terminal repeat-containing
                     protein"
                     /name="topoisomerase C-terminal repeat-containing protein"
     gene            2734..2975
                     /locus_tag="EQB72_RS16055"
                     /pseudo=""
     CDS             2734..2975
                     /locus_tag="EQB72_RS16055"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002425012.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="peptide-binding protein"
                     /name="peptide-binding protein"
     gene            3024..3107
                     /locus_tag="EQB72_RS16060"
     CDS             3024..3107
                     /locus_tag="EQB72_RS16060"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001814874.1"
                     /GO_process="GO:0046677 - response to antibiotic [Evidence
                     IEA]; GO:0031556 - transcriptional attenuation by ribosome
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="23S rRNA methyltransferase attenuation leader
                     peptide"
                     /protein_id="WP_001814874.1"
                     /translation="MLVFQMRNVDKTSTVLKQTKNSDYADK"
                     /name="23S rRNA methyltransferase attenuation leader
                     peptide"
     gene            3232..3969
                     /gene="erm(B)"
                     /locus_tag="EQB72_RS16065"
     ARG             3233..3966
                     /name="erm(B)"
                     /gene="erm(B)"
                     /gene_name="23S rRNA (adenine(2058)-N(6))-methyltransferase
                     Erm(B)"
                     /tool="amrfinderplus"
                     /drug_class="LINCOSAMIDE/MACROLIDE/STREPTOGRAMIN"
                     /identity="100.0"
                     /coverage="100.0"
     gene            <4139..4399
                     /locus_tag="EQB72_RS16075"
                     /pseudo=""
     CDS             <4139..4399
                     /locus_tag="EQB72_RS16075"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000108743.1"
                     /GO_component="GO:0005694 - chromosome [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003916 - DNA topoisomerase activity [Evidence IEA]"
                     /GO_process="GO:0006265 - DNA topological change [Evidence
                     IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="topoisomerase DNA-binding C4 zinc finger
                     domain-containing protein"
                     /name="topoisomerase DNA-binding C4 zinc finger
                     domain-containing protein"
     gene            4562..>5227
                     /locus_tag="EQB72_RS16080"
                     /pseudo=""
     CDS             4562..>5227
                     /locus_tag="EQB72_RS16080"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558228.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="IS1182-like element IS1182 family transposase"
                     /name="IS1182-like element IS1182 family transposase"
     gene            5263..5508
                     /locus_tag="EQB72_RS16085"
     CDS             5263..5508
                     /locus_tag="EQB72_RS16085"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000567888.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="single-stranded DNA-binding protein"
                     /protein_id="WP_000567888.1"
                     /translation="MIDVNELLEEAIRETENLNDGEVFLVKDLFKGYVGNRIPRKDRLL
                     LGTLFLNHVSKMNGNLKAIEKTSSNQQRYKKTIDKF"
                     /name="single-stranded DNA-binding protein"
     gene            5611..6480
                     /locus_tag="EQB72_RS16090"
     CDS             5611..6480
                     /locus_tag="EQB72_RS16090"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002328890.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotidyltransferase domain-containing protein"
                     /protein_id="WP_000228166.1"
                     /translation="MVDNIIKSVAEKLSSLSYIEGIVLGGSRARGTHTEDSDIDIGIYY
                     NSESFDINTINQFATKLDDEHRNNLVVPPGAWGDWINGGGWLVINGYHVDLILRDIKRV
                     EQIMKDTEHGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAETYPNA
                     LQKSLVNFFMFEAGFSLMFVKANSGTDDKYYIAGHVFRIVSCLNQVLFACNNAYCINEK
                     KAIKLLETFEHKPEKYTEKVNHIFEVLGISLFECYDMTEKLYNEVNEIVSEINNFLNEE
                     SSDERKQI"
                     /name="nucleotidyltransferase domain-containing protein"
     gene            6461..7195
                     /locus_tag="EQB72_RS16095"
     CDS             6461..7195
                     /locus_tag="EQB72_RS16095"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016250180.1"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]; GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_000662263.1"
                     /translation="MKENKYDDNIFFQKYSQMSRSQKGLAGAGEWETLKKMLPDFKGKR
                     VLDLGCGYGWHCIYAMENGASSVVGVDISHKMLEVAKGKTHFPQIEYECCAIEDVDFPE
                     ESFDVILSSLAFHYVADYENLIKKIYRMLKAGGNLVFTVEHPVFTAHGTQDWYYNEKGE
                     ILHFPVDNYYYEGKRTAMFLEEKVTKYHRTLTTYLNTLLSNSFIINQIVEPQPPENMMD
                     IPGMADEMRRPMMLIVSAKKKM"
                     /name="class I SAM-dependent methyltransferase"
     gene            7228..8136
                     /locus_tag="EQB72_RS16100"
     CDS             7228..8136
                     /locus_tag="EQB72_RS16100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032491779.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminoglycoside nucleotidyltransferase ANT(6)-Ia"
                     /protein_id="WP_001255866.1"
                     /translation="MRSEKEMMDLVLSLAEQDERIRIVTLEGSRANINIPKDEFQDYDI
                     TYFVSDIEPFISNDDWLNQFGNIIMMQKPEDMELFPPEEKGFSYLMLFDDYNKIDLTLL
                     PLEELDNYLKGDKLIKVLIDKDCRIKRDIVPTDIDYHVRKPSAREYDDCCNEFWNVTPY
                     VIKGLCRKEILFAIDHFNQIVRHELLRMISWKVGIETGFKLSVGKNYKFIERYISEDLW
                     EKLLSTYRMDSYENIWEALFLCHQLFRAVSGEVAERLHYAYPEYDRNITKYTRDMYKKY
                     TGKTGCLDSTYAADIEERREQ"
                     /name="aminoglycoside nucleotidyltransferase ANT(6)-Ia"
     gene            8133..>8360
                     /locus_tag="EQB72_RS16105"
                     /pseudo=""
     CDS             8133..>8360
                     /locus_tag="EQB72_RS16105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000627290.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /name="hypothetical protein"
     gene            complement(8414..9094)
                     /locus_tag="EQB72_RS16110"
     CDS             complement(8414..9094)
                     /locus_tag="EQB72_RS16110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="WP_001015311.1"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            9156..9851
                     /locus_tag="EQB72_RS16115"
     CDS             9156..9851
                     /locus_tag="EQB72_RS16115"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002326819.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_127843689.1"
                     /translation="MQQNPTEDVSHFLTNKEHLNEVIRRIQKDFSCMEEMKYFIQRVEE
                     QLYLESETSQTKVTVSHNRLDVYKRRPETVKKGTELLRLETEKYIMNVYLERSELVENF
                     VSYTICRKHYYSESEYYSIFESMELMEEEMEELNSKDATVDDYYLVFTRFLTCGTESIV
                     LMGMDYELAVPEAFLREYVEEVDNPGDDWYTTLTDFLDTYTYDDTEEIQNELDRKQMPY
                     QRFERKKGQ"
                     /name="hypothetical protein"
     gene            10016..10216
                     /locus_tag="EQB72_RS16830"
     CDS             10016..10216
                     /locus_tag="EQB72_RS16830"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002341525.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002338055.1"
                     /translation="MNKIIPLLFVLCIGEILMRHGAAVHLNFVVFLGILIFCLIFWRFV
                     LALVSLIFKLIAAIFFIGLFR"
                     /name="hypothetical protein"
     gene            10232..10411
                     /locus_tag="EQB72_RS16125"
     CDS             10232..10411
                     /locus_tag="EQB72_RS16125"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002295613.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002305761.1"
                     /translation="MPIAIGNKRLPVTLDEKRQKELQQLKQKYGKSESKIMCIALDLLI
                     AQEKAGFDIPALKK"
                     /name="hypothetical protein"
     gene            10821..11222
                     /gene="tnpA"
                     /locus_tag="EQB72_RS16130"
     CDS             10821..11222
                     /gene="tnpA"
                     /locus_tag="EQB72_RS16130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_045009167.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS200/IS605 family transposase"
                     /protein_id="WP_002305759.1"
                     /translation="MSEIHYGRGYVYSIQYHLVWCVKYRHDVLYGQVDIDVKQFLKQIA
                     DDNNIKIIEIESDKDHIHLLIECTPQHYIPSIVKVFKGASARLLFKKHPELKQLLWGGH
                     LWNPSYFVATVSENTEEQIRKYIQNQKKK"
                     /name="tnpA"
     gene            11234..12379
                     /gene="tnpB"
                     /locus_tag="EQB72_RS16135"
     CDS             11234..12379
                     /gene="tnpB"
                     /locus_tag="EQB72_RS16135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002305757.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS200/IS605 family element RNA-guided
                     endonuclease TnpB"
                     /protein_id="WP_002305757.1"
                     /translation="MLQHRAYKFRIYPNQEQEILMTKTIGCSRFVYNYFLNLWNHEYTT
                     TGKGLSYNSCSAMLPQMKRNAETIWLKEVDSIAIQSSLKNLSDAFSRFFKKQNKRPQFK
                     SKKHPIQSYTTKNVNNSIEIRNNFVKLPKLGFVKFAKSQEPKGRILNATIRKNSSGKFF
                     VSILCEEEIVEFPKSNSAIGIDLGITDFAILSDGQKIDNNKFTSKMAKKLKREQRKLSK
                     RALLAKKKGVNLFEAKNYQKQKRKVARLHEKVMNQRNDFLNKLSTEIIKNHDIICIEDL
                     NTKGMLRNHKLAKSISDVSWSSFVTKLQYKANWYGRKIIKVDKWFPSSQICSNCGHKDG
                     KKSLEIREWTCPVCHAHHDRDINASINILTEGLRLHVMGLA"
                     /name="tnpB"
     gene            12617..12880
                     /locus_tag="EQB72_RS16140"
     CDS             12617..12880
                     /locus_tag="EQB72_RS16140"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002329851.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002287514.1"
                     /translation="MEMLPIKKWGNSNGLRLPKYIMEYLGIHTEDKVKIIQEEVNGQKR
                     LIIEAANIENELTIEQLFENYTDERNHVTIQNLGEAVGNEKW"
                     /name="hypothetical protein"
     gene            12874..13224
                     /locus_tag="EQB72_RS16145"
     CDS             12874..13224
                     /locus_tag="EQB72_RS16145"
                     /EC_number="3.1.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016610020.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003723 - RNA binding [Evidence IEA]; GO:0004521 - RNA
                     endonuclease activity [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system PemK/MazF family
                     toxin"
                     /protein_id="WP_002321032.1"
                     /translation="MVRKPRQGDILLLNTAPRSGHEQTGKRPYIVLSHDIIADYSNVVT
                     VAPISSTTRNYPLYVNINSEYEMKTTGKVLLDQLTTIDYEARECIFLEKAHDSLVEELL
                     MKVRTVFQKVSK"
                     /name="type II toxin-antitoxin system PemK/MazF family
                     toxin"
     gene            complement(13248..13862)
                     /locus_tag="EQB72_RS16150"
     CDS             complement(13248..13862)
                     /locus_tag="EQB72_RS16150"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001261742.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_002318230.1"
                     /translation="MRVAYIRVSSIDQNEQRQIEEMKKFGAERIFIEKQSGATITHRPV
                     FQEALDFVRDQDIFIVEAIDRLGRNYDEIIASVNYLKKKNVQLIITSLPIMAEAIGNPL
                     LDKFIKDLIIQILAMIAEQERTESKRRQAQGIKIAKANGVYKGRPKLYSANAKDPQRRL
                     VYKNIVEDLKKGVAIAKIAKDYNVTRQTVYRIKKDSMVNHE"
                     /name="recombinase family protein"
     gene            14176..14598
                     /locus_tag="EQB72_RS16155"
     CDS             14176..14598
                     /locus_tag="EQB72_RS16155"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002303116.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002288787.1"
                     /translation="MKNKFILSLGILTIGISVTGTTIPTFADSTNEPTTVVDNNQELTP
                     LDRNGIAIGNPTNDLTVTENYLIVSPLLARAASKTIRVTGTMIFDKVGWPSRPPQSRNW
                     KEKRNGYWYYGKLYLQSYKSAGNNWIATYSGTLTRK"
                     /name="hypothetical protein"
     gene            14608..14811
                     /locus_tag="EQB72_RS16160"
     CDS             14608..14811
                     /locus_tag="EQB72_RS16160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016631607.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002299573.1"
                     /translation="MPEFVNTPNFYQDSDILSKINLPKEESALQVQRTLQETQKIQKSI
                     SNLEDSEEKRKKRDQKTYQKEK"
                     /name="hypothetical protein"
     gene            15022..15606
                     /locus_tag="EQB72_RS16165"
     CDS             15022..15606
                     /locus_tag="EQB72_RS16165"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007207927.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_002299575.1"
                     /translation="MKIGYARVSTGLQNLDLQEDSLNKFGCEKIFTDHMSGAKSNRPGL
                     EMAIDFVRSGDTLVVWRLDRLGRNMEDLISIVNRLNERGVSFHSIQENITMDKSSSTGQ
                     LMFHLFAAFAEFERNLILERSAAGRAAARARGRFGGRPEKLSEQDLELLKTLVDSGTPI
                     KTIAERWNVSRTTIYRYLAKMEEKNGKTNSH"
                     /name="recombinase family protein"
     gene            15775..17100
                     /locus_tag="EQB72_RS16170"
     CDS             15775..17100
                     /locus_tag="EQB72_RS16170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002335330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Y-family DNA polymerase"
                     /protein_id="WP_002303115.1"
                     /translation="MMDYSKEPVNDYFLIDMKSFYASVECIERNLDPLTTELVVMSRSD
                     NTGSGLILASSPEAKKRYGITNVSRPRDLPQPFPKTLHVVPPRMNLYIKRNMQVNNIFR
                     RYVADEDLLIYSIDESILKVTKSLNLFTTEETRSQRRKKLAQMIQERIKEELGLIATVG
                     VGDNPLLAKLALDNEAKHNEGFIAEWTYENVPEKVWNIPEMTDFWGIGSRMKKRLNQMG
                     ILSIRDLANWNPYTIKNRLGVIGLQLYFHANGIDRTDIAIPPEPTKEKSYGNSQVLPRD
                     YTRRNEIELVVKEMAEQVAIRIRQHNCKTGCVHLNIGTSILETRPGFSHQMKIPITDNT
                     KELQNYCLFLFDKYYEGQEVRHVGITYSKLVYTDSLQLDLFSDPQKQINEENLDKIIDK
                     IRQKYGFTSIVHASSMLESARSITRSTLVGGHAGGNGGIKND"
                     /name="Y-family DNA polymerase"
     gene            17093..17443
                     /locus_tag="EQB72_RS16175"
     CDS             17093..17443
                     /locus_tag="EQB72_RS16175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002359653.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002303114.1"
                     /translation="MIDYNDRGRLKWAGFYLSDHTEEIDADNEQRTSQNLAKEQMTTEE
                     IAEVLNAAVIKNRSVSIQKEERNAEGYYPEDIVGKILGSDELGIYVGKDKIHYDEIRHI
                     EFYQDNKWSRLE"
                     /name="hypothetical protein"
     gene            complement(17500..18180)
                     /locus_tag="EQB72_RS16180"
     CDS             complement(17500..18180)
                     /locus_tag="EQB72_RS16180"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="WP_060797357.1"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GILA"
                     /name="IS6-like element IS1216 family transposase"
     gene            complement(18234..18452)
                     /locus_tag="EQB72_RS16185"
     CDS             complement(18234..18452)
                     /locus_tag="EQB72_RS16185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002347151.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002347151.1"
                     /translation="MNNKNTKNTNTNHEKRSFFDKLFKKKKNGKVSILKMIGWIFLAFF
                     IVAVNSSGGDKKEAASKDTTKGSVAKF"
                     /name="hypothetical protein"
     gene            complement(18500..18772)
                     /locus_tag="EQB72_RS16190"
     CDS             complement(18500..18772)
                     /locus_tag="EQB72_RS16190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002303415.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002303415.1"
                     /translation="MLGSFKKDKEVKTRGALTPSQQNKLGTKATFHPVRDQANQKELIG
                     VCVGFTSEKFFPIIECKIHGITTREVARKVVKWHTSQTKTNHKKR"
                     /name="hypothetical protein"
     gene            complement(18762..18971)
                     /locus_tag="EQB72_RS16195"
     CDS             complement(18762..18971)
                     /locus_tag="EQB72_RS16195"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002303414.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002303414.1"
                     /translation="MIRKLNNIKLSLAILTLFFGIYNNSRMALFFLTLLIFMNLIIHNF
                     KELENTAPAPSQGNQESEGMPHAW"
                     /name="hypothetical protein"
     gene            complement(19102..19380)
                     /locus_tag="EQB72_RS16200"
     CDS             complement(19102..19380)
                     /locus_tag="EQB72_RS16200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002303413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002303413.1"
                     /translation="MEKKEDLLNAFKNLDEKDQLKALLRLHDITYSDIAERLTVKKGER
                     EGQKGVSLVTVQKAFQSKTNLESDRWKEIVKVATKLIEERQNDQNKA"
                     /name="hypothetical protein"
     gene            complement(19685..19993)
                     /locus_tag="EQB72_RS16205"
     CDS             complement(19685..19993)
                     /locus_tag="EQB72_RS16205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002303412.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002303412.1"
                     /translation="MKEMKMKQVIYPVIIGVLAIALIILGVNCYNLSKENNQLETKNNK
                     QEIQIAKQAYVISDYKTYFRENYVDTVKYRSHFTDKQILNVYREALRDGKISDEGAN"
                     /name="hypothetical protein"
     gene            complement(20167..20535)
                     /locus_tag="EQB72_RS16210"
     CDS             complement(20167..20535)
                     /locus_tag="EQB72_RS16210"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002347150.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002347150.1"
                     /translation="MENTNQTPNTAPTNQTSPAERKADLIRLYSRLEGMKLQHVPTAPK
                     APDGFPKSAESLEFFECKVCGSTFQTILRESVASGCPKCEHDRLGILADHLPEPDKNSC
                     LNNRKKPVTVMAMGFLCI"
                     /name="hypothetical protein"
     gene            complement(20649..21464)
                     /locus_tag="EQB72_RS16215"
     CDS             complement(20649..21464)
                     /locus_tag="EQB72_RS16215"
                     /inference="COORDINATES: protein motif:HMM:NF013235.4"
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006270 - DNA replication initiation
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /protein_id="WP_002347149.1"
                     /translation="MVDSNGKPILNKYGKPKKVVKMPIDNSVTLSIQRLRHLASLGNES
                     NKQIVDRYFSNQPEPLTINEQMELLQTGINLHSIYMVDENENEIITAPAIARWVINKHT
                     LEVTARINPEYLEWFSEVVNQYILFNLRDFVKLKSKYSMILFLELSTFWNTGMYYKRIN
                     DLREILGVNPTRNNRDFINNVLKPAIAALKEYFPELSLTVEKNSSDSRKITHVRLKFDK
                     LTITDMQERLRSSEGASLVEYQQELENMEGEEKAVNDPTPEIDLSNVEW"
                     /name="replication initiation protein"
     gene            21548..22228
                     /locus_tag="EQB72_RS16220"
     CDS             21548..22228
                     /locus_tag="EQB72_RS16220"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="WP_001015311.1"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            22285..22464
                     /locus_tag="EQB72_RS16665"
     CDS             22285..22464
                     /locus_tag="EQB72_RS16665"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001021554.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001021554.1"
                     /translation="MNIIQQYELKYITFDQLSEEIWGYGQRLINEVGVERFSFYVEAAA
                     GYHNFRFYIFPLYI"
                     /name="hypothetical protein"
     gene            22600..22890
                     /locus_tag="EQB72_RS16230"
     CDS             22600..22890
                     /locus_tag="EQB72_RS16230"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000026576.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000026576.1"
                     /translation="MSINTFVYSHPINVYIIKNLGITVEQFCELYAYPQGTVASWITRQ
                     RRIKSLPASFVYDLSLASSLNMSDVYEKLLSLEKEYDSFKIKHDKKIKKHI"
                     /name="hypothetical protein"
     gene            complement(23095..24273)
                     /locus_tag="EQB72_RS16235"
     CDS             complement(23095..24273)
                     /locus_tag="EQB72_RS16235"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000997695.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS256-like element ISEf1 family transposase"
                     /protein_id="WP_000997695.1"
                     /translation="MNDFTTEIVQTLVTKGDLNELFRSHLEKAINTLLRTELTAFLDYE
                     KYDRTGFNSGNSRNGSYFRSIKTEYGELTLEIPRDRNGEFKQQTLPAYKRTNDTLETTI
                     IHLFEKGVTMSEIADLIEKMYGHHYTPQTMSNMTKVLTEEVNAFKSRALNDKYVAIFMD
                     ATYIPLKRQTVSKEAIYIAIGIREDGTKEVLSYAIAPTESTYVWNELLQDINSRGVQEV
                     LLFITDGLKGMKDTIHQIYPKAKYQHCCIHVSRNIAHKVRVKDRKEICDDFKAVYQANS
                     KEEANTFLSGMIEKWKKNYPKVTQSLIENQDLLTFYDFPPSIRRTIYSTNLIESFNKQI
                     KRYSRRKEQFQNEESLERFLVSIFDTYNQKFLNRSHKGFQQVTDTLVSMFTE"
                     /name="IS256-like element ISEf1 family transposase"
     gene            24604..25392
                     /locus_tag="EQB72_RS16240"
     CDS             24604..25392
                     /locus_tag="EQB72_RS16240"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002302898.1"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA];
                     GO:0016887 - ATP hydrolysis activity [Evidence IEA]"
                     /GO_process="GO:0007059 - chromosome segregation [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="WP_002302898.1"
                     /translation="MARILSVANQKGGVSKTTTSVNLAACLKFVYGKNVLLVDIDPQGN
                     ATDNVGFDIDGTNQPTIYEVLKGEADITDAILDYKGIDVLPADIALSSAEREFTQVGSE
                     HRLKRVLQPIKDNYDYIIIDCPPSLGMLTVNAFTVSDEIIIPVEAAYFSLKGLIKLSET
                     IETVKEYTNDKLEVRGVLFTKYNKRYNISKEMTTAATEISRVIGAKIFKTYIRRTITVD
                     EAQAAGSDLINFNKPSTAEDDYKAFTEEYLKEVGDFDGRR"
                     /name="AAA family ATPase"
     gene            25379..25705
                     /locus_tag="EQB72_RS16245"
     CDS             25379..25705
                     /locus_tag="EQB72_RS16245"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002299230.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002299230.1"
                     /translation="MAEDNRSQAAVSRLLGNKNKKNYKPKEVEEIELTKKNISKVIKDQ
                     GSSVRTADSIRINPILMSALKYWTTIAESDKSKPDVIEDALLKSIPEEYLIEGYKLAKK
                     QNKI"
                     /name="hypothetical protein"
     ARG             7229..8133
                     /name="ant(6)-Ia"
                     /gene="ant(6)-Ia"
                     /gene_name="aminoglycoside nucleotidyltransferase
                     ANT(6)-Ia"
                     /tool="amrfinderplus"
                     /drug_class="AMINOGLYCOSIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             3233..3969
                     /name="ErmB"
                     /gene="ErmB"
                     /gene_name="Erm 23S ribosomal RNA methyltransferase"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic; lincosamide antibiotic;
                     streptogramin antibiotic; streptogramin A antibiotic;
                     streptogramin B antibiotic"
                     /identity="98.37"
                     /coverage="98.79"
     ARG             8134..8384
                     /name="SAT-4"
                     /gene="SAT-4"
                     /gene_name="streptothricin acetyltransferase (SAT)"
                     /tool="rgi"
                     /drug_class="nucleoside antibiotic"
                     /identity="98.68"
                     /coverage="46.11"
     ARG             7229..8136
                     /name="aad(6)"
                     /gene="aad(6)"
                     /gene_name="ANT(6)"
                     /tool="rgi"
                     /drug_class="aminoglycoside antibiotic"
                     /identity="100.0"
                     /coverage="109.42"
     Typing          2..1041
                     /name="rep_cluster_889"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.808"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 atgaatgatt ttaattatta caaatcaaaa gaaatttatc gtgaaaaata ttatcaaatg
       61 cctaaggtat tttttactaa cgaaaaatac atggatcttt caaatgatgc aaaaattgct
      121 tatatgctac ttaaagatcg atttgattat tcagtcaaaa ataactgggt agattctgat
      181 gataatatat ttttcatatt cacagttgaa gaattaatga aattgttaca atgccgcgaa
      241 ggtaaagtat ctaaaatcaa aaaggaatta gaaaaagcag gtcttctgaa acagaagaga
      301 ggaagagtaa ataaacgtga cggtaagatt gaatccatgc ctaatttatt gtacttaggc
      361 aagccagaag taacgaatca agacgtcttt aaaatcatgg aagaggaaga caatactgat
      421 accaccgtaa ttgcgaaaat cgcaaatacg gcaaaaccgc gagaaatcaa tgataccacc
      481 gtaattgcga aaatcgcaaa tacggcaaaa tccagtcata tcaaggactc aaccgtaatt
      541 gcgaaaatcg cagacaatct attctattct aattctatag acactaatag acacataata
      601 gacactgaaa ctgatcagtt acaaaatcaa gttttactag ataacttcgt cgacatcatg
      661 aaagaggaca gtataaatac atttgtacca gaaaatgtat taaacttgat aaaaacattt
      721 tctagtactt acgaagacgc tcaaaaaacc gtccaaacta ttcataatgc aaagaaaaaa
      781 gctgaagaat tagagcaaac agttgttgtt tatgaagaac ttgaatctta tggaattgat
      841 gctgacaaag gattatatat gactttgctg aaagcttatc aaaaacaaaa aactgaaaaa
      901 gtaaacaatt tgcagaatct aattttcgtt tatgtaaaaa attggtttgt cgaaaaagct
      961 attgcggcaa agcttgcaaa cgaacaaaga gaaacattta acgaattacc aacagttagt
     1021 acggaaaatt ggctagagta gttgataaaa agcgatcact ataaaaatga tcaattttaa
     1081 attagaactt ttttatgatt ttaattttat tacaaatgtt acaaataaat agctattatt
     1141 ccggagtttt tagattaaaa gtttatgaaa acaatcacaa acgtaggttt taaagtcata
     1201 atcgttagat attttagtta tttttcattc aaaaaaatag ggaactagtg tttgcatatg
     1261 tgcttttttg agttataata attcatgaag agaggtaatt cacttatttc cccaagctga
     1321 aaagcctgat attacttctt ttcaggcagt gctgctaata ttcaattaca cttttttgta
     1381 tatttttagt tgttttaaat ttaattgtct gatatgcttg tgatgaattg attttcgttc
     1441 tgcacttttg gacgataaat tgtgataatt gaaaatacaa aaaaaagaaa ggcccctgta
     1501 aggctcggga gactggtaat ctccgtcagt gtcctacagg aaagcattaa gatgacgcct
     1561 taatgcgtgc ccttcagtgt tacggtatta cccgcaacgg acggttctgt tgcaaagttt
     1621 taaataaaga ataaaatccc ttacggtatc tatgatttaa gctgggattc ccaataatac
     1681 cttgatttca gtacagaccg aaaacccgaa gagagtgcct tcttttcggg ttttcttata
     1741 taatcctcga atggcttcca tgcctttaat cgtggtagag gcagtgcgta aacttcgata
     1801 gaatttattg cgtctcttta ctggacgatg gtcttgttca atcaaattat tcaggtattt
     1861 aatggtacga tgttctgtcc cttgataaaa gccgtattct tttagtttct taaaggcact
     1921 tgtaatagag ggggctttat ctgtgactac aaccttcggt tcatcaaact gcttcactaa
     1981 ccgcttaaga aaagcatagg ctgcttgtgt gtcccgtttt ttacgtaacc aaatatccaa
     2041 ggttaaacca tctgcatcga tggctcgata caaataatgc cattttcctt taattttgat
     2101 gtacgtttca tccattttcc atgaataaaa ggatttttta tttttctttt tccaaatttg
     2161 atagagtagt ttgccatatt cttgcaccca acgataaatc gtcgtatgag aaacgttaat
     2221 gccacgatca tataagattt cttgaacttc acgatagcta aggttataac gaagatagta
     2281 gcccacggct acaataatca catcctgctg aaattgcttt cctttaaaat gattcatcgt
     2341 cattcctcct gctatctttt tctattattc taccttattt gatagtagat ttaaaacttt
     2401 gcaacagaac ccctgaatgt aagtttactt tagctgaaca ttttagaaag aaaaaactaa
     2461 ccaaaacgaa tgtaaaagaa ttactggagg gaaaagaaac cctggtaaaa ggaatcaaaa
     2521 acaaagagaa aaagccctac aatgccgttg taaaaattgg ggaaaaggga tatattgatt
     2581 ttatatcttt ctcaaaataa acataaaagc cctttaaaga gggcttttat atattaatca
     2641 caaatcactt atcacaaatc acttatcaca aatcacaagt gatttgtgat tgttgatgat
     2701 aaaataagaa taagaagaaa tagaaagaag tgagtgattg tgggaaattt aggcgcacaa
     2761 aaagaaaaac gaaatgatac accaatcagt gcaaaaaaag atataatggg agataagacg
     2821 gttcgtgttc gtgctgactt gcaccatatc ataaaaatcg aaacagcaaa gaatggcgga
     2881 aacgtaaaag aagttatgga aataagactt agaagcaaac ttaagagtgt gttgatagtg
     2941 cagtatctta aaattttgtg tataatagga attgaagtta aattagatgc taaaaatttg
     3001 taattaagaa ggagggattc gtcatgttgg tattccaaat gcgtaatgta gataaaacat
     3061 ctactgtttt gaaacagact aaaaacagtg attacgcaga taaataaata cgttagatta
     3121 attcctacca gtgactaatc ttatgacttt ttaaacagat aactaaaatt acaaacaaat
     3181 cgtttaactt ctgtatttat ttacagatgt aatcacttca ggagtgatca catgaacaaa
     3241 aatataaaat attctcaaaa ctttttaacg agtgaaaaag tactcaacca aataataaaa
     3301 caattgaatt taaaagaaac cgataccgtt tacgaaattg gaacaggtaa agggcattta
     3361 acgacgaaac tggctaaaat aagtaaacag gtaacgtcta ttgaattaga cagtcatcta
     3421 ttcaacttat cgtcagaaaa attaaaactg aacattcgtg tcactttaat tcaccaagat
     3481 attctacagt ttcaattccc taacaaacag aggtataaaa ttgttgggag tattccttac
     3541 catttaagca cacaaattat taaaaaagtg gtttttgaaa gccatgcgtc tgacatctat
     3601 ctgattgttg aagaaggatt ctacaagcgt accttggata ttcaccgaac actagggttg
     3661 ctcttgcaca ctcaagtctc gattcagcaa ttgcttaagc tgccagcgga atgctttcat
     3721 cctaaaccaa aagtaaacag tgtcttaata aaacttaccc gccataccac agatgttcca
     3781 gataaatatt ggaagctata tacgtacttt gtttcaaaat gggtcaatcg agaatatcgt
     3841 caactgttta ctaaaaatca gtttcatcaa gcaatgaaac acgccaaagt aaacaattta
     3901 agtaccgtta cttatgagca agtattgtct atttttaata gttatctatt atttaacggg
     3961 aggaaataat tctatgagtc gcttttttaa atttggaaag ttacacgtta ctaaagggaa
     4021 tggagataaa ttattagata tactactgac agcttccaag aagctaaaga ggtccctagc
     4081 gcctacgggg aatttgtatc gataaggggt acaaattccc actaagcgct cgggacccct
     4141 tgtaggaaaa tgtcctaagt gtggcaacaa tattgtatta aaaaaatcgt tttatggttg
     4201 ttcaaattat cctgaatgta agtttacttt agctgaacat tttagaaaga aaaaactaac
     4261 caaaacgaat gtaaaagaat tactggaggg aaaagaaacc ctggtaaaag gaatcaaaaa
     4321 caaagagaaa aagccctaca atgccgttgt aaaaattggg gaaaagggat atattgattt
     4381 tatctctttt tcaaaataaa catggggctg acccaaaagt agctcctata tgaaaaatag
     4441 aggtctttcc atttagatag tagtggaaag acctctattt atcttttgaa agtgaataca
     4501 aaaataaagc acactctgct ataatatagg tgattaatcc atttgagaga ggtgctttat
     4561 catgtatcaa aattatacca taaaccaact ttgtttgcct atagatcttg aaattaaatt
     4621 agaagaaaat gattttgctc atgccattgt gcagtttgtt gactctattc ccgatgaagt
     4681 ctttcttcct tattatcaat ctatgggtag accccaatat catcctcgta tgctactttc
     4741 cattattctt tgtgcctata ttcaaggggt ttattcgggc cgccaaatac aaaatatgct
     4801 gatagatagt attcggatgc gctacttatc tcaagagcaa ttccctaact ttcgtactat
     4861 taatcgtttt cgcgttcatc cgattatgaa cgatattcta gatcattcat ttgttcaatt
     4921 tcgtgagcta ctggttcaaa gtggcttaat cagtggcagt gctctataca ttgatggtac
     4981 aaaaattgaa gcggatgcga ataaatactc tttcgtttgg aaaaaaagta ttttaaagta
     5041 taaggatagc cttgatcaaa aagcccttga aaactaccaa caaatggtgg aaacaaaaat
     5101 cttacctgag ttaatagatg atttaaagga tgaactttct atagaagaga ttgaaaggat
     5161 tcgtcaatct ttggaagaaa aggaaaatca attaattgaa gcgattgacc aaaccgaaac
     5221 agtagaaggg ggctgaccca ttattaataa ggagtggaca acatgattga tgtaaatgag
     5281 ctattggaag aagctattag agaaactgaa aatctaaatg atggcgaagt ttttcttgtt
     5341 aaagatttat tcaagggata tgtggggaat aggataccca gaaaggatcg acttctgctt
     5401 ggaacgttat ttttaaacca tgttagcaaa atgaatggta atttaaaggc tattgaaaag
     5461 acttcatcta atcagcagag gtataaaaag acaattgata agttttaact atcttttgtg
     5521 aaattaaaaa aattataaat atgttgagta gaagcaaaag atttggcttg gaatttttac
     5581 agcagtgaat cgataaaagg agcatgcttg atggtagata atattattaa atcagtagca
     5641 gagaaattat cctctctgtc ttatatagaa ggtattgttt taggtggttc acgtgcaagg
     5701 ggcacccata cagaggattc ggatatagat atcggcatct attacaattc agaatcattt
     5761 gacataaata ctattaatca attcgctaca aagctggatg atgagcatag aaataacctt
     5821 gttgtacctc ccggagcatg gggtgattgg attaatggcg gcggatggtt agtcataaac
     5881 gggtatcatg tggatttaat tttacgtgat attaaacgtg tggaacaaat aatgaaagat
     5941 acagagcacg gaattgttac tgccaattat cagactgggc atccccatgg ttatattagt
     6001 gcaatgtatc gaggagaatt agcgattagc aaaatactat atgctaagaa tgaaagctta
     6061 tgcgaattaa aaaaacaggc agaaacttat cccaatgctt tgcagaaaag tttagttaac
     6121 ttttttatgt ttgaagcagg gttctcttta atgtttgtaa aagcaaattc gggaacagac
     6181 gataaatatt atattgcggg tcatgttttt cgtatagttt catgtttaaa tcaagtgtta
     6241 tttgcatgta ataatgctta ttgtatcaac gaaaagaaag ctataaaact gcttgaaact
     6301 tttgaacata aacctgaaaa atataccgag aaggtaaatc atatttttga agtactcggt
     6361 atctcacttt ttgaatgcta cgacatgacc gagaagcttt ataatgaagt gaatgaaatt
     6421 gtatcggaga taaataactt tttaaacgag gagagttcag atgaaagaaa acaaatatga
     6481 tgataatata ttttttcaaa aatacagtca aatgagtcgc tcgcagaaag gactggctgg
     6541 tgcgggagaa tgggagactt tgaaaaagat gctacctgat tttaagggta agcgtgtgct
     6601 tgatttagga tgcggctatg gatggcactg tatatatgcg atggaaaacg gtgcttcctc
     6661 tgtagtaggt gttgatattt ctcataaaat gctcgaagta gcaaaaggaa aaacccattt
     6721 tccacagatt gaatatgaat gctgtgccat agaagatgtg gatttcccag aggagagctt
     6781 tgatgtaata ctaagttcgc ttgcgtttca ttatgtagca gactatgaga atttaataaa
     6841 aaagatatat aggatgctga aggctggtgg caatttagtt tttacagttg aacatcctgt
     6901 ttttactgct catggaacac aagactggta ttataacgaa aaaggagaaa tactgcattt
     6961 cccggtggac aattattatt atgagggcaa acggacagct atgtttttgg aagaaaaggt
     7021 tacaaaatat catagaacac tgaccacata tctaaataca ctgctttcaa atagttttat
     7081 aataaatcag attgtggagc cacagccgcc agagaacatg atggatattc cggggatggc
     7141 ggatgaaatg cgacgcccaa tgatgctgat tgtatcggca aaaaagaaga tgtaataata
     7201 tagaaaaaat aaacgaggag tatgtaaatg agatcagaaa aagaaatgat ggatttagta
     7261 ctttctttag cagaacagga tgaacgtatt cgaattgtga cccttgaggg gtcacgcgca
     7321 aatattaata tacctaaaga tgaatttcag gattatgata ttacatattt tgtaagtgat
     7381 atagaaccgt ttatatctaa tgatgactgg cttaatcaat ttgggaatat aataatgatg
     7441 caaaagccgg aggatatgga attattccca cctgaagaaa agggattttc ctatcttatg
     7501 ctatttgatg attacaataa aattgatctt accttattgc ccttggaaga gttagataat
     7561 tacctaaagg gcgataaatt aataaaggtt ctaattgata aagattgtag aattaaaagg
     7621 gacatagttc cgactgatat agattatcat gtaagaaagc caagcgcaag ggagtatgat
     7681 gattgctgca atgaattttg gaatgtaaca ccttatgtta ttaaaggatt gtgccgtaag
     7741 gaaattttat ttgctattga tcattttaat cagattgttc gccatgagct gctgagaatg
     7801 atatcatgga aggtcggcat cgaaacaggc tttaaattaa gtgtaggcaa gaactataag
     7861 tttattgaaa ggtatatatc cgaggatttg tgggagaaac ttttgtccac ctaccggatg
     7921 gattcctatg aaaacatatg ggaagcatta tttctatgcc atcaattgtt cagggcggta
     7981 tccggtgagg tggcggaaag gcttcattat gcctatccgg agtatgatag gaatataaca
     8041 aaatatacca gggacatgta taaaaaatac actggtaaaa ccggctgcct ggatagcaca
     8101 tatgccgctg atatagaaga gaggcgggaa cagtgattac agaaatgaaa gcagggcacc
     8161 tgaaagatat cgataaaccc agcgaaccat ttgaggtgat aggtaagatt ataccgaggt
     8221 atgaaaacga gaattggacc tttacagaat tactctatga agcgccatat ttaaaaagct
     8281 accaagacga agaggatgaa gaggatgagg aggcagattg ccttgaatat attgacaata
     8341 ctgataagat aatatatctg gttctgttgc aaagttttaa ataaagaata aaatccctta
     8401 cggtatctat gatttaagct gggattccca ataatacctt gatttcagta cagaccgaaa
     8461 acccgaagag agtgccttct tttcgggttt tcttatataa tcctcgaatg gcttccatgc
     8521 ctttaatcgt ggtagaggca gtgcgtaaac ttcgatagaa tttattgcgt ctctttactg
     8581 gacgatggtc ttgttcaatc aaattattca ggtatttaat ggtacgatgt tctgtccctt
     8641 gataaaagcc gtattctttt agtttcttaa aggcacttgt aatagagggg gctttatctg
     8701 tgactacaac cttcggttca tcaaactgct tcactaaccg cttaagaaaa gcataggctg
     8761 cttgtgtgtc ccgtttttta cgtaaccaaa tatccaaggt taaaccatct gcatcgatgg
     8821 ctcgatacaa ataatgccat tttcctttaa ttttgatgta cgtttcatcc attttccatg
     8881 aataaaagga ttttttattt ttctttttcc aaatttgata gagtagtttg ccatattctt
     8941 gcacccaacg ataaatcgtc gtatgagaaa cgttaatgcc acgatcatat aagatttctt
     9001 gaacttcacg atagctaagg ttataacgaa gatagtagcc cacggctaca ataatcacat
     9061 cctgctgaaa ttgctttcct ttaaaatgat tcatcgtcat tcctcctgct atctttttct
     9121 attattctac cttatttgat agtagattta aaactttgca acagaaccca acggaagatg
     9181 tgtcacactt tttaacaaac aaagaacatt tgaatgaagt aatcagacgg attcaaaaag
     9241 actttagttg tatggaagaa atgaagtact ttattcaaag agtcgaagaa caattgtatt
     9301 tggaaagtga aacgagtcaa acgaaggtca cagtcagcca taatcgttta gacgtgtata
     9361 aacgtcgtcc tgaaacggta aaaaaaggaa cggagcttct acgactagaa acagaaaaat
     9421 acatcatgaa tgtttaccta gaaaggagtg agctggtcga aaactttgtc agctacacga
     9481 tttgcaggaa acactattac tcagaatcag aatattattc aatttttgag agcatggaat
     9541 taatggaaga agaaatggaa gagctaaaca gcaaagatgc gacggtagac gattattacc
     9601 ttgtatttac tagattttta acgtgtggaa cggaatctat cgtgctaatg ggaatggatt
     9661 acgaactcgc tgtacccgaa gcgtttttga gggaatatgt agaagaagta gataacccag
     9721 gggatgattg gtacacgact ttaactgatt tcttagacac ctacacttac gacgatacag
     9781 aagaaatcca aaatgagctt gaccgtaaac aaatgccata tcaacgattt gaaaggaaaa
     9841 aaggtcaata atcatttata ccgaaaagtg agaatgtgtg aaataagaac aaaaaacctt
     9901 gaaattaagg gaatggttct tatttcgcac caatcgctcc aaccgccccc gccgcttagg
     9961 tggtgcgaaa taagcgggca aagcccgata acctaagaga aagaaggaga tccatatgaa
    10021 taaaatcatt cctctgttgt tcgtactgtg tattggcgag atacttatgc gtcatggtgc
    10081 agctgtacat ttaaacttcg tagtattctt aggaatactg atattttgtt tgatcttttg
    10141 gcgctttgtg ttagcccttg tgagtctaat attcaagttg attgcagcca tatttttcat
    10201 agggttattt cgatgaaagg agagagtact aatgccaatt gcaataggaa ataaacggtt
    10261 acccgtgaca ttagatgaaa agagacaaaa agaattgcag caactaaagc agaagtacgg
    10321 aaaaagtgaa tctaagatta tgtgtattgc gttagatcta ttgatcgcgc aagaaaaagc
    10381 aggatttgat ataccagcac taaaaaagtg acgtcacttt tcatttgaag aaacaaaagt
    10441 gatagcactt aattgttcct actatttaga atattttcta tgtccttttt attccatttt
    10501 gtatcaataa ctatgaaatc tttaaagtat ccagaagaga ttatttttag atcaattttt
    10561 ttcttacctg attctaaaga ttttgttttc ttaaacatat tatgatttcc tttcgactat
    10621 tttcatataa atgttaacat agtttatgga ctagccgaga acacccgtga ttttaatcat
    10681 gggatgaatc ggattcagtt gtgacctagc tttagctagg ttaaacaact gacaaatata
    10741 aactaaataa tagtgaaatg tcttgcaata attgattttg tagaaataca tatattaaaa
    10801 taattgcgag gtgtttttgt atgtcagaaa ttcattatgg acggggttat gtctattcta
    10861 ttcaatatca tcttgtttgg tgtgtaaaat atcgacatga tgttttgtat ggtcaggtag
    10921 atattgatgt caaacagttt ttgaaacaaa ttgctgatga taataatata aaaattatag
    10981 aaatagaatc agataaagac catattcatt tactcattga atgcacccca caacactata
    11041 ttcctagtat tgttaaagta tttaaaggcg catccgctag actgctgttt aaaaaacatc
    11101 ctgaacttaa acaactcctt tggggtggac atctttggaa tccaagctac tttgtagcta
    11161 ctgttagcga aaatacagaa gaacaaatta gaaaatatat acaaaatcag aaaaagaaat
    11221 gaggtgaatc cgtatgctac aacatagggc ttataaattt agaatctatc ctaatcaaga
    11281 acaagaaata ttaatgacta aaactattgg ctgttcaaga tttgtctata attatttttt
    11341 gaatttgtgg aatcatgaat atacgactac tggaaaagga ttatcttata attcttgttc
    11401 tgccatgctt ccacaaatga aaagaaatgc agagacaatt tggttaaaag aagttgacag
    11461 tattgcgatt caatcctcat tgaaaaatct ttctgatgct ttttctcgct tctttaaaaa
    11521 gcaaaataaa cgaccacaat ttaaaagtaa aaaacatcct atacaaagtt atacaactaa
    11581 aaatgtgaat aatagtatcg aaattagaaa caatttcgta aaactaccta agttaggatt
    11641 tgttaaattt gcgaaaagtc aagagcccaa agggcgaatc ttaaatgcta cgattcgaaa
    11701 aaattcgagt ggtaaatttt ttgtttccat cctgtgtgaa gaagaaatag ttgagtttcc
    11761 taaatctaat tccgctattg gaatcgacct tggtataact gattttgcaa tcctttctga
    11821 tggtcaaaag attgataaca ataaattcac gtcaaaaatg gcaaaaaaac tcaaacgtga
    11881 acaacgtaag ttgtcaaaac gtgcattact agctaaaaag aaaggcgtca atctctttga
    11941 agctaaaaat tatcaaaaac aaaaacgaaa agtagcacga ctacatgaaa aagtaatgaa
    12001 tcaacgcaat gactttttaa acaagttgag cacagagatt atcaaaaacc acgatattat
    12061 ctgtatagaa gacttaaata caaaaggtat gttgcgtaat cataaactag caaaaagcat
    12121 ttctgatgtg tcttggtcta gttttgtgac taagttacaa tacaaagcta actggtacgg
    12181 tcggaaaatc atcaaagtag ataaatggtt tccatctagt caaatctgtt caaattgtgg
    12241 acacaaagac ggcaagaaat ctctagaaat tcgagaatgg acttgtcctg tttgtcatgc
    12301 tcatcatgac cgagatatca atgctagtat caatattttg accgaaggtc taagattaca
    12361 tgtcatggga ttagcttaga tccaatcatc aaaaaccgta ggaactacgg ggatagcttg
    12421 gtaaataaga gaaaccgctg tgagtaaaga aatacgcttg caagtatgct ctattcccaa
    12481 gaatctcgtg actttagtca tgagaggttc aaggattcat ggaatgttaa tctaatttaa
    12541 tagaaaagga taattaagta tatacgtttt ttcttatgta tgttatacta tgtatataca
    12601 gaaagaggtg tctactatgg aaatgttacc tataaaaaaa tggggaaata gtaatggcct
    12661 tagattgcca aagtatatta tggaatatct tggaattcat acagaagaca aagtgaagat
    12721 aatacaagaa gaagtaaacg gtcagaagcg gctaattatc gaagcggcta atatagaaaa
    12781 tgaattaaca attgaacagt tatttgaaaa ttacactgat gaaagaaatc atgtgacgat
    12841 tcaaaattta ggtgaagcag taggtaatga aaaatggtga gaaaacctag acaaggcgat
    12901 attctattat tgaatacagc acctcgatct ggacacgaac agacaggtaa aagaccttat
    12961 attgttttaa gtcatgatat tattgcggat tatagtaacg ttgttacagt tgctccaatt
    13021 tctagtacaa ctagaaacta tccgctatat gtaaatataa actcagaata tgaaatgaag
    13081 acaacaggaa aagtattatt agatcaacta acgacaattg attatgaagc cagagagtgt
    13141 atttttttgg aaaaagcgca tgatagttta gttgaggagt tattgatgaa agttagaaca
    13201 gtttttcaaa aagtaagcaa ataaaataga aacagcagca tgatcaacta ttcgtgattg
    13261 accatgctgt ctttttttat tctatatacg gtttgtctcg taacattgta gtcttttgca
    13321 atcttagcga tcgcaacacc tttttttaga tcctcaacga tgtttttata aacaagacga
    13381 cgttggggat cttttgcatt ggcactgtat agcttaggac gtcctttata aacaccgttc
    13441 gcttttgcaa tcttaatgcc ttgtgcctga cgtcgtttag attcggtacg ttcttgttca
    13501 gcgatcatgg ccaaaatttg aatgatcaaa tctttaatga atttatccag gagaggattg
    13561 ccaattgctt cggccatgat cggtagactt gtgatgatca gctgcacatt tttcttcttc
    13621 aagtaattga ctgaagcgat gatctcgtcg taatttcttc caagtcgatc aatagcttcc
    13681 acaataaaaa tatcttgatc tcggacgaaa tccagtgctt cttgaaaaac aggtcgatga
    13741 gtaatcgttg cgccagattg tttctcaatg aaaattctct ctgcaccgaa ttttttcatt
    13801 tcttcaatct gccgttgttc attttgatcg atggatgaga cacgtatgta tgcaactctc
    13861 aaaattttta cctactttct gcaactattt aaaaaacacc ctaatcatac acgagaaaac
    13921 cagatttttc aatgtcgcgg tcgtgtctag ttagggtata ccttatatag acaaaaacta
    13981 atgatggagg aaatagtatg tgtcactttt ctttttaaat ggcaatattt tttgtaaata
    14041 aatgtcaatc aagaaaattt aaacgattat gacattaaaa atatatttta tgaattttct
    14101 agtatataac ttgatttatc tgttaagatt tattaagaaa acgttttctt atttttgatt
    14161 tcgaggtgat agacaatgaa aaataagttt attttatctt taggtatttt aactattgga
    14221 attagtgtaa ctggaactac aattcctaca tttgctgata gtacaaatga accaactact
    14281 gtagtagata ataaccaaga attaactcct ttagatagga acggaatagc cattggtaac
    14341 ccaactaacg acttaactgt tactgaaaat tatttaatag tttctccatt acttgctcga
    14401 gcagcttcta aaacgatacg agtgacagga acgatgattt ttgataaagt tggttggcct
    14461 tctagacctc ctcaatcacg gaattggaaa gaaaaaagaa atggttattg gtactatgga
    14521 aaattgtatt tacaaagtta taaatcagct ggaaacaatt ggattgcgac ttattcagga
    14581 accttaacta gaaagtaggg attttttatg ccagaatttg tgaacacacc aaatttttat
    14641 caagatagcg atattctaag taaaattaat ttaccgaaag aagaatcagc tttacaagtt
    14701 cagcgaactt tacaggagac acaaaaaatt caaaaatcaa tttctaatct agaagattct
    14761 gaagaaaaaa gaaaaaaaag agaccaaaaa acatatcaaa aagaaaaata atgattttaa
    14821 aaaaagagtg tctagtcgac attctttttt tctaattgaa agtgttcata aaatcaccca
    14881 tttctggaca cttccttttt ttgctttatt tttcaaaaaa acaattcatt tcatgttcat
    14941 aaacccataa caatatctat gttcagttaa actatatgga taaagttatg ttacaataaa
    15001 attaatgaag gagtgatttt tttgaaaata ggatacgccc gggtatctac tggtttacaa
    15061 aatttggatt tacaagaaga cagcctaaat aaatttggtt gtgaaaaaat ttttactgat
    15121 catatgagtg gggcaaaaag taatcgacca ggattagaaa tggccattga ttttgttcgc
    15181 tctggcgata cacttgtcgt ttggcgctta gatcgtttag gtagaaatat ggaagatttg
    15241 atttcaatcg tcaatcgact gaatgagcgt ggtgtgagtt ttcatagtat tcaagaaaat
    15301 attacgatgg acaaatcaag ttctacagga cagctcatgt ttcatttgtt tgcggcattt
    15361 gcagaatttg agcgtaattt gatcctggaa cgatccgcag caggacgagc agctgctcgt
    15421 gcaagaggac ggtttggtgg tcgtcctgaa aaattgtctg aacaagattt ggaattactg
    15481 aagactttag tggatagcgg tacacctatt aagactattg cggaacggtg gaacgtctca
    15541 agaaccacca tttatcgtta tttggcaaaa atggaggaga aaaatggaaa gacaaattct
    15601 cattagtttt tgtcatttaa tgctgaaaat ttttgccatt tatctagaaa agtgacaata
    15661 gtatgagaat tttttgtaag tgtctactga taacttattc tcaaatattt agctatttct
    15721 tctttacaac atcgaacata tgtttgtata atgtggaaga atggagtgtt atttatgatg
    15781 gattattcaa aagagccagt aaatgattac tttttaatcg atatgaaaag cttttacgca
    15841 agtgtcgaat gtatagaaag aaatttagat ccattaacaa cagaacttgt tgttatgagt
    15901 cgatctgata atactggttc aggattgata ttagcttctt ctcctgaagc aaaaaagcgg
    15961 tatggtatta caaatgtgag tagaccacgt gacttaccac aaccatttcc taaaacacta
    16021 cacgttgttc caccacgtat gaacctatat atcaagcgaa atatgcaggt aaataatatt
    16081 ttcagaagat atgtggctga tgaagatcta ctgatttact cgatcgatga atcgatttta
    16141 aaagtgacaa aatcactgaa tctttttacg actgaagaaa cacgaagtca gcgaaggaag
    16201 aagctcgctc aaatgatcca agaacgtatt aaagaagagt taggtttgat tgctacggta
    16261 ggcgtcggcg ataatcccct tttggctaaa ttagccttag acaatgaagc aaagcataat
    16321 gaaggattta ttgcggaatg gacgtacgaa aacgttcctg agaaagtatg gaatattccc
    16381 gaaatgacgg acttttgggg aattggttcg cgaatgaaaa aaaggctcaa ccaaatggga
    16441 attttgagca ttagagacct tgctaactgg aatccttata cgattaagaa tagattaggt
    16501 gtgattggat tacagctgta cttccatgct aacggaatcg atcgaacaga tatagcaatc
    16561 ccgccagaac cgacaaagga aaaatcttat ggtaattcac aagtgttacc acgagattat
    16621 actagaagaa atgaaatcga gctggtggta aaagaaatgg cggaacaagt agccattcgt
    16681 atcaggcagc ataattgtaa aacaggatgt gttcatttaa acattggtac gtcgatctta
    16741 gaaacgagac caggattttc acaccagatg aaaataccta tcacagataa tacaaaggaa
    16801 ttgcagaatt attgtctttt cttgtttgat aagtattatg aaggacaaga agtaaggcac
    16861 gttggaataa cctatagcaa gcttgtgtac accgattcgc ttcagctgga tttatttagt
    16921 gatccacaaa agcaaattaa cgaagaaaat ttagataaaa ttattgacaa gattcggcaa
    16981 aaatatggtt ttacgtcgat tgtacatgct tcttcaatgt tagaaagcgc tagaagcatt
    17041 actagaagca cacttgttgg tggtcatgcg ggcggaaatg ggggaattaa aaatgattga
    17101 ttacaatgat cgtggacgtt taaagtgggc agggttttat ttatctgatc atactgaaga
    17161 aattgatgcc gacaatgaac aacgaaccag tcaaaattta gcaaaagaac aaatgacgac
    17221 tgaagagatt gcggaagtat tgaacgctgc agtcataaaa aatagatcag tatctattca
    17281 aaaagaagaa cgaaacgctg aaggatacta tccagaagat attgttggca agatcttagg
    17341 tagtgatgag ctggggatct acgttggaaa agacaaaatt cactacgacg aaatacgtca
    17401 tatcgaattt taccaggata ataaatggag tcgattagaa tgaacggttc tgttgcaaag
    17461 ttttaaataa agaataaaat cccttacggt atctatgatt taagctagga ttcccaataa
    17521 taccttgatt tcagtacaga ccgaaaaccc gaagagagtg ccttcttttc gggttttctt
    17581 atataatcct cgaatggctt ccatgccttt aatcgtggta gaggcagtgc gtaaacttcg
    17641 atagaattta ttgcgtctct ttactggacg atggtcttgt tcaatcaaat tattcaggta
    17701 tttaatggta cgatgttctg tcccttgata aaagccgtat tcttttagtt tcttaaaggc
    17761 acttgtaata gagggggctt tatctgtgac tacaaccttc ggttcatcaa actgcttcac
    17821 taaccgctta agaaaagcat aggctgcttg tgtgtcccgt tttttacgta accaaatatc
    17881 caaggttaaa ccatctgcat cgatggctcg atacaaataa tgccattttc ctttaatttt
    17941 gatgtacgtt tcatccattt tccatgaata aaaggatttt ttatttttct ttttccaaat
    18001 ttgatagagt agtttgccat attcttgcac ccaacgataa atcgtcgtat gagaaacgtt
    18061 aatgccacga tcatataaga tttcttgaac ttcacgatag ctaaggttat aacgaagata
    18121 gtagcccacg gctacaataa tcacatcctg ctgaaattgc tttcctttaa aatgattcat
    18181 cgtcattact cctgctatct ttttctatta ttctacctta tttgatagta gatttaaaac
    18241 tttgcaacag aaccctttgt ggtatctttt gaagcagcct ctttcttatc accgccgcta
    18301 ctgttcacag caactatgaa aaaggctaaa aatatccagc cgatcatttt caaaatagat
    18361 acttttccat tcttcttctt tttgaaaagc ttatcaaaga agcttctctt ctcgtggtta
    18421 gtattggtat ttttggtgtt tttgttgttc attcttaaat ctcccttaat ttaattttca
    18481 aacgctctta ggaacgtttt taacgtttct tatggttggt tttggtttgg ctggtgtgcc
    18541 atttcacaac ttttctagca acttctctag ttgtgatccc gtgtattttg cactctatta
    18601 ttggaaaaaa tttctctgaa gtaaacccta cacaaacgcc aattagttct ttttggttgg
    18661 cttgatctcg gacggggtgg aaagtggctt ttgtaccaag cttattttgc tggcttggtg
    18721 taagggctcc tcgtgttttt acttccttat cctttttaaa actaccaagc atgtggcatg
    18781 ccctcacttt cttggtttcc ttgagagggc gctggagctg tattttctaa ctccttgaaa
    18841 ttatggataa ttaagttcat gaatatcaat aacgtaagaa aaaacaaagc cattctggaa
    18901 ttattgtaaa ttccaaaaaa tagtgttaaa attgccaaag aaagcttgat attattaagt
    18961 tttctaatca tttctaaatc tccttagtgg ttatttggta aatggtttgg tagcttttag
    19021 ggcgtgtggt tacccctaaa agtaaatggt gtggctcgtt cattttattg ctttggtcag
    19081 cggtaaatgg acgggctttt tttatgcttt gttctggtcg ttttgtcgct cttcaattag
    19141 cttggtagcg acttttacaa tctctttcca gcgatcactc tccaagttgg tctttgattg
    19201 gaaagctttt tgtacagtca cgaggctaac acctttttgt ccttccctct cgcctttttt
    19261 aacggttaat ctttcagcaa tatcgctgta tgttatatca tgaagcctta ataacgcttt
    19321 aagttgatct ttctcgtcta ggttcttaaa agcgttcaat aaatcttcct ttttctccaa
    19381 cttaccacct cccttccgat ttttagttag aaatcgctcc aagggtcttc ctcttcttct
    19441 ggcggctttc tcactaagta ttcattttcc tttataccaa cgattttccg ccactcttgt
    19501 tcccaatctt ggttattatc atagtttttg gaaagttctt ggatacgctt ctccagctcc
    19561 tctattttct gatctctttc ccgatctgct tcctcatatc ctattcggat tctttccagc
    19621 tgttaggctt ctcgttcacg cttcttttcc tgtaataaca tagccagcaa aatgagctct
    19681 tccactagtt agctccctca tcgctgattt ttccatctct aagagcttct cgataaacat
    19741 ttaaaatttg tttatcagtg aagtgggagc gatatttcac ggtgtctaca tagttttcac
    19801 gaaaataagt cttgtaatcg ctgataacgt aagcttgctt ggctatttgg atttcttgct
    19861 tgttgttttt ggtctcaagt tgattatttt ccttgcttaa gttatagcaa tttacaccaa
    19921 ggataataag agcgatagct aaaactccaa taatcacggg ataaattact tgcttcattt
    19981 tcatttcttt catattactt tctctccttt aattggttgg tttggtattt tcaaaagaga
    20041 acggtactca ttccgccatt acgctttaac cctcgtaccc tttcgatata tttatattac
    20101 taccagtggt agtataattt aatagatttt ttaaaataaa tccataaata acccttggaa
    20161 attatctcaa atacacaaaa accccatagc cataacggtt acaggttttt ttcgattatt
    20221 taaacaactg tttttgtctg gttctggtaa atgatcggct aaaattccta agcgatcatg
    20281 ttcacatttg gggcagccac tcgcaacgga ttcccttaaa atcgtttgaa aagtcgatcc
    20341 gcacacctta cactcgaaaa actcaaggct ctctgccgat tttgggaagc cgtctggcgc
    20401 ctttggagcg gtcggaacgt gttggagttt cataccttca aggcgtgagt acaatctaat
    20461 aagatcggct ttgcgttcgg ctgggctagt ttggttagtt ggtgctgtat ttggtgtttg
    20521 gttagtgttt tccatgttgg ttatagctcc tttattttgc ttggtttggt ataggactag
    20581 aaggctctaa aaggagccct cgcgccttac aagtactttg gtttattgga ttagattgct
    20641 gacaggtgtt accattccac gttggaaagg tcgatctctg gagttggatc gttgacagct
    20701 ttttcctctc cttccatatt ttccaactct tgttggtact ctactaaaga agctccctcg
    20761 ctgcttctta ggcgttcttg catatcggtt attgttagct tatcaaactt caatcttaca
    20821 tgagtgatct ttctggagtc gctagaattc ttttccactg ttaggcttag ctctggaaag
    20881 tactctttga gagcagcgat agcaggcttt agaacgttgt ttataaaatc tctgttattt
    20941 ctcgttggat tgactcctaa aatttctctt aaatcattaa tccttttata atacattcct
    21001 gtattccaaa aggtagaaag ctctaagaaa aggatcatgg agtacttact ttttaacttc
    21061 acaaagtctc ttagattaaa taaaatgtat tggttaacca cttctgaaaa ccactctaaa
    21121 tattctggat tgatccgcgc tgttacttct agcgtatgct tatttattac ccaccttgct
    21181 atagcgggcg cggttatgat ctcattttca ttttcatcta ccatataaat agagtgtaaa
    21241 tttatccccg tttggagtaa ttccatttgc tcgttaattg tcagaggttc tggctggttt
    21301 gaaaagtaac gatcaactat ttgtttgttg ctttcgtttc ctaagcttgc taggtgccgt
    21361 aggcgctgaa tactcaaagt aaccgagtta tctatcggca tttttactac ctttttcggc
    21421 tttccatatt tgtttaagat aggcttgccg ttactatcta ccatagttac aagggttctg
    21481 ttgcaaagtt ttaaatctac tatcaaataa ggtagaataa tagaaaaaga tagcaggagt
    21541 aatgacgatg aatcatttta aaggaaagca atttcagcag gatgtgatta ttgtagccgt
    21601 gggctactat cttcgttata accttagcta tcgtgaagtt caagaaatct tatatgatcg
    21661 tggcattaac gtttctcata cgacgattta tcgttgggtg caagaatatg gcaaactact
    21721 ctatcaaatt tggaaaaaga aaaataaaaa atccttttat tcatggaaaa tggatgaaac
    21781 gtacatcaaa attaaaggaa aatggcatta tttgtatcga gccatcgatg cagatggttt
    21841 aaccttggat atttggttac gtaaaaaacg ggacacacaa gcagcctatg cttttcttaa
    21901 gcggttagtg aagcagtttg atgaaccgaa ggttgtagtc acagataaag ccccctctat
    21961 tacaagtgcc tttaagaaac taaaagaata cggcttttat caagggacag aacatcgtac
    22021 cattaaatac ctgaataatt tgattgaaca agaccatcgt ccagtaaaga gacgcaataa
    22081 attctatcga agtttacgca ctgcctctac cacgattaaa ggcatggaag ccattcgagg
    22141 attatataag aaaacccgaa aagaaggcac tctcttcggg ttttcggtct gtactgaaat
    22201 caaggtatta ttgggaatcc cagcttaaat catagatacc gtaagggatt ttattcttta
    22261 tttaaaactt tgcaacagaa ccgaatgaac attatccagc aatatgagct aaagtatata
    22321 acctttgatc agctatcaga agagatttgg ggttatggcc aacgtttgat aaatgaggtt
    22381 ggtgttgagc gcttctcttt ctatgtagaa gctgcagcag gttatcataa ttttaggttt
    22441 tatattttcc cgttatatat ataaggtatt ttacggattc tatagagtta tctctatgaa
    22501 tccttttttg tttttacaaa taggagtaga tactagaata atgcgtgtgt taaactatta
    22561 ttgcaaacgc aataataaaa gaaagtaggc ttacgcacca tgtctatcaa tacatttgtt
    22621 tactcgcacc cgatcaatgt ttacattatc aagaatttag gaatcactgt agaacaattt
    22681 tgtgagttat atgcctaccc acaaggaacg gttgcaagct ggataacccg acaacgtaga
    22741 ataaaatcat tacctgcttc attcgtttat gatttaagcc tggcctctag tttaaacatg
    22801 tctgatgttt atgaaaagct cctgtcttta gaaaaagaat atgattcctt caagattaaa
    22861 catgataaaa aaataaaaaa acatatataa tatcaatcac aattgtataa tattacgata
    22921 tcttaatatc atgatatcgt aatattgttt ttttctaaga aaatgcacta taagaaggga
    22981 attattagta acaatataga cagtttaata atgtttaaat tattctagtt gctgctcgca
    23041 aagggagcgt caataatttt gtgtaaataa attgtcctcc tgcaaaataa ttagttactc
    23101 agtaaacatt gaaactaatg tatcggttac ctgttgaaaa cctttatggc ttctgtttag
    23161 aaatttttga ttgtatgtat caaaaatgct gactagaaag cgttctagtg attcttcatt
    23221 ttgaaactgc tcttttctac ggctgtatct tttaatttgc ttattgaaag actcgattag
    23281 attggttgag taaatggttc tacgaatgct aggtggaaaa tcataaaaag ttaataagtc
    23341 ttggttttct atgagtgact gcgtcacttt aggatagttt ttcttccatt tctcaatcat
    23401 gccggataag aaggtattcg cttcttcttt tgagttagct tgataaacag ccttaaagtc
    23461 atcacagatt tcttttcggt ctttgacacg tactttatga gcgatgttac gagatacatg
    23521 gatacaacaa tgctgatatt ttgctttagg ataaatttga tggatagtat ctttcatgcc
    23581 ttttaagccg tccgtaataa aaagcaagac ttcttgaact cctctggagt taatatcctg
    23641 tagcagctca ttccaaacgt atgttgattc agttggagca atcgcataac tcagtacttc
    23701 tttagtgccg tcttctcgta taccaatggc aatataaatc gcttctttgg atacggtttg
    23761 acgttttagt ggaatgtaag tagcgtccat aaaaatagcg acatacttat catttaaggc
    23821 tctggattta aaggcattta cttcttcagt cagaacttta gtcatgttgg acatggtttg
    23881 tggagtatag tgatgaccgt acattttttc gatcaaatca gcaatttcag acatcgtaac
    23941 acctttttcg aataaatgga taatagtggt ttccaatgta tcgtttgttc ttttgtaggc
    24001 tggtaaagtt tgttgtttaa actcaccatt acgatctcta ggtatttcca atgttaattc
    24061 accatattcg gttttgattg atcgaaagta agaaccgttt ctcgaattac ctgaattaaa
    24121 accagtgcga tcatattttt cgtaatctaa aaaagccgtt aattcagtcc gtaggagtgt
    24181 gtttatcgct ttttctaagt gcgaacggaa taattcattt aaatcgcctt tagtgactag
    24241 agtttgcaca atttctgtag taaaatcatt catagggaag tcctcttttc tgtgaattgg
    24301 ttgtcgttaa ctttattcta cagaagcgac ttcctttttt gtatggattt tttcatttac
    24361 acaaaatatt ttacactctc ctcgcaaaac atatttctta tgattaataa aaaattttaa
    24421 agtaataaaa agtgattatt ttactttcga ataacatatg aataatcttt atatccgaac
    24481 cgatatatat ctttaaaaca aaataatcac acaatattac aatataatgc atatacgata
    24541 ttgcaatatc acaatattat gatataatta tattataata taagatgaat gggggatatt
    24601 ttaatggcaa gaatattgtc agtagccaat caaaaaggtg gagtttctaa aactacgact
    24661 agcgttaatt tagcagcatg tttgaaattt gtttacggta aaaatgtact tttagtggac
    24721 attgatcctc agggaaatgc tacagataat gtaggtttcg atatagatgg aacaaaccaa
    24781 cctacaattt atgaagtatt aaaaggggag gctgacatta cagatgctat tctggactat
    24841 aaaggaattg atgttttgcc agccgacata gccctttctt ctgcagagag ggaatttact
    24901 caagtaggaa gtgaacacag gcttaaaaga gtacttcaac caatcaagga caactatgat
    24961 tatattataa ttgattgtcc accaagttta ggaatgctta cagtcaacgc atttactgtt
    25021 tctgatgaaa ttatcattcc agttgaagct gcgtatttct cattaaaagg actaataaag
    25081 ttaagtgaaa ctattgaaac ggtaaaagaa tatacgaacg acaagcttga agtacgagga
    25141 gtcctattta ctaagtataa taagcgttat aacatttcta aagaaatgac gactgcagca
    25201 accgaaattt ctagagtcat tggtgcaaaa attttcaaaa cttatattcg tagaacaata
    25261 accgttgacg aagcgcaagc tgctggatca gatctaatca attttaataa accctcaaca
    25321 gctgaagatg actataaagc atttacagaa gaatatttaa aagaagttgg tgattttgat
    25381 ggcagaagat aatcgcagtc aagctgcagt aagtagacta ctaggaaata aaaataaaaa
    25441 gaactacaaa ccaaaagaag tagaagaaat cgaattaacc aagaaaaata taagtaaagt
    25501 cataaaagat caaggaagta gtgtaagaac agcagatagc attcgtataa atccaattct
    25561 aatgtcagca ctcaaatatt ggacgactat tgctgaatca gacaaaagta aaccagacgt
    25621 tatagaagat gcgctattaa aatccatacc tgaagaatac ttgattgaag gatataaact
    25681 agcaaagaaa caaaataaaa tttaatttac attcaatatc acgatatcat aatatcgtga
    25741 tatttttttt ataaaaatca gtagtatcaa agctgataag tcgcttatct tcatattgta
    25801 atattacgat atcgtgatat aatgttattg taatatcgtg atatagttac catgagctta
    25861 aaccctgaaa tagagcggtt tgctttaatt tattttttaa ggtaaactaa aaaaagataa
    25921 aaaaagacta ctgctttaac aaagtttggc gacttatcag cagtagaaaa atatatagtg
    25981 gatagatata tttgtttaat tcattgtaac atagttttga acaaaacgct atcctacaga
    26041 aagaggattg gct
//
