LOCUS       NZ_LR135282            19928 bp    DNA     linear   CON 13-FEB-2024
DEFINITION  Enterococcus faecium isolate E6975 plasmid 5.
ACCESSION   NZ_LR135282
VERSION     NZ_LR135282.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMEA4884860
            Assembly: GCF_900639395.1
KEYWORDS    RefSeq.
SOURCE      Enterococcus faecium
  ORGANISM  Enterococcus faecium
            Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
            Enterococcus.
REFERENCE   1  (bases 1 to 19928)
  AUTHORS   Arredondo-Alonso,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-DEC-2018) UNIVERSITY MEDICAL CENTER UTRECHT,
            Heidelberglaan 100, 3584 CX Utrecht, Netherlands
COMMENT     ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/13/2024 03:06:26
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,323
            CDSs (total)                      :: 3,230
            Genes (coding)                    :: 3,091
            CDSs (with protein)               :: 3,091
            Genes (RNA)                       :: 93
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 71
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 139
            CDSs (without protein)            :: 139
            Pseudo Genes (ambiguous residues) :: 0 of 139
            Pseudo Genes (frameshifted)       :: 54 of 139
            Pseudo Genes (incomplete)         :: 84 of 139
            Pseudo Genes (internal stop)      :: 31 of 139
            Pseudo Genes (multiple problems)  :: 25 of 139
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            LR135282.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..19928
                     /organism="Enterococcus faecium"
                     /mol_type="genomic DNA"
                     /isolate="E6975"
                     /db_xref="taxon:1352"
                     /plasmid="5"
     gene            102..314
                     /locus_tag="EQB65_RS17065"
     CDS             102..314
                     /locus_tag="EQB65_RS17065"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014834536.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002349227.1"
                     /translation="MAVWQIQLKERGAYGLISLSDVLCRKEMPDLFSLDQIIAIIGAAA
                     VVITAVAKASDSILAWLKFKKEQKK"
                     /name="hypothetical protein"
     gene            476..994
                     /locus_tag="EQB65_RS17070"
     CDS             476..994
                     /locus_tag="EQB65_RS17070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000357244.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YfbU family protein"
                     /protein_id="WP_000357244.1"
                     /translation="MDKFNRLTLINQFEILKALNPNEEKYYAEKIEILTEGYEYHYSEI
                     FENISDPLPEEDSRFVLDILNMYRDITFSKNKLKDINSIDNYYIQFKGFDFNSSTEFKL
                     ALYAQFFIEKLNRFQEIVEDSDFNTFNSHKPMRGTYIKFLENYNDLKSTNNYQFGNLSY
                     EMISKVLSL"
                     /name="YfbU family protein"
     gene            1001..1513
                     /locus_tag="EQB65_RS17075"
     CDS             1001..1513
                     /locus_tag="EQB65_RS17075"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000774078.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000774078.1"
                     /translation="MKLNSINDLFAIIGVIANILFSCLNFRFTQKNKKNKLSIEQMKKD
                     IETDLKNDHKERRKIEEYTSLMEKCKATDAIFSFLRKSDEIITRENIDLENEISKLESI
                     FSDINSLKYLIVEENSDSFLEFEKYLTDLIDNRNNELMRQNIARFLTKLVSEWKSIISQ
                     NMDKLRY"
                     /name="hypothetical protein"
     gene            1784..2332
                     /locus_tag="EQB65_RS17080"
     CDS             1784..2332
                     /locus_tag="EQB65_RS17080"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016620180.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_010729662.1"
                     /translation="MYLAYLRVSSDDQSLARQHKLIENWSVKNNIAEDDLKIFEEKVSG
                     KNIENRPELQELISFIRERDTIIIPSLDRLARNSKDTKDLLQLFRSKGASIEILDLPSF
                     NGVTDPALRDLLTNLVIEVFSYVAENERKKIKERQKQGIEIAKKNGRYTGKKIQYHANA
                     TGKNKLIYDEIVDGSVAKF"
                     /name="recombinase family protein"
     gene            2386..3066
                     /locus_tag="EQB65_RS17085"
     CDS             2386..3066
                     /locus_tag="EQB65_RS17085"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="WP_001015311.1"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            3264..3869
                     /locus_tag="EQB65_RS17090"
     CDS             3264..3869
                     /locus_tag="EQB65_RS17090"
                     /EC_number="2.7.7.108"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016176895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protein adenylyltransferase Fic"
                     /protein_id="WP_000599739.1"
                     /translation="MILENKLGLTNQVELAKVEEKLSKQKAKELYDCGKINEIEVGTFK
                     GLSEIHEFLFSDIYDFAGKIRSVNIAKGNFRFAPVMYLEHSLQHIDQMPQTSFEEIIKK
                     YVEMNIAHPFREGNGRSTRIWLDLILKEELQKVVDWNLIDKADYLSAMERSPINDLEIR
                     YLISNALTDKIDDRELYMKGIDVSYFYEGYSEYTIDDL"
                     /name="protein adenylyltransferase Fic"
     gene            3885..4457
                     /locus_tag="EQB65_RS17095"
     CDS             3885..4457
                     /locus_tag="EQB65_RS17095"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000170424.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_002303206.1"
                     /translation="MTKYGYARVSTASQSTKEQIQQLLENCVEKKNIFSEKFTGTKRDR
                     PKFNQLLAGLKPGDEIVVTKLDRFARNTREALEIIEPLLDDNVTIKVLNLGTIENTSMG
                     RMVTRTLLSVAEMERDMIVERTQEGKMFARKNNPNFREGRPKATITPKKRHAYELLTSG
                     KSYKEVEAITGFSRSTLFRIKKKIEES"
                     /name="recombinase family protein"
     gene            complement(4930..5502)
                     /locus_tag="EQB65_RS17105"
     CDS             complement(4930..5502)
                     /locus_tag="EQB65_RS17105"
                     /inference="COORDINATES: protein motif:HMM:NF033516.0"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
                     /protein_id="WP_073120187.1"
                     /translation="MCQKNCCHSIISKENLLNQDFSTETICEKWAADITYIPTKKNGWC
                     YLSSIMDLHTKRIISYTFSKRMTVDCVIQTLNKAKIHYHIPEGMILHTDLGSQYTAREV
                     EQWLKTNKIRHSYSRKGTPYDNAGIESFHASLKKEEVYTTSYSDFEEANRALFSYIEGF
                     YNRNRIHSSIHYLTPQEFEELAKEKMA"
                     /name="IS3 family transposase"
     gene            complement(5603..6765)
                     /locus_tag="EQB65_RS17110"
     CDS             complement(join(5603..6489,6489..6765))
                     /locus_tag="EQB65_RS17110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611768.1"
                     /ribosomal_slippage=""
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS3 family transposase"
                     /protein_id="WP_086953888.1"
                     /translation="MSKRTRRTFSQEFKQQIVNLYLAGKPRVEIIREYELTASAFDKWV
                     KQFKTSGSFKEKDNLTPEQKELLELRKRNQQLEMENDILKQAALIFGPKRQVIDANKHL
                     YPISAMCRILGLSRQSYYYQSKPKKDESELEEVVAEEFIRSRKAYGSRKIKKALSKRGI
                     QISRRKISRIMKNRGLKSSYTVAYFKVHHSTCNEAKTTNVLNRKFLRDNPLEAIVTDLT
                     YVRVGKKWNYVCFILDLFNREILGYSCGEHKDAVLVKKAFSRIKQPLTEVEIFHTDRGK
                     EFDNQAIDELLTTFDINRSLSHKGCPFDNAVAESTYKSLKVEFVYQYTFETLQQLDLEL
                     FDYVNWWNHLRLHGTLGYETPVGYRNQRLAQRILDNELGCANASEAV"
                     /name="IS3 family transposase"
     gene            complement(7171..7425)
                     /locus_tag="EQB65_RS17120"
     CDS             complement(7171..7425)
                     /locus_tag="EQB65_RS17120"
                     /inference="COORDINATES: protein motif:HMM:NF013677.4"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0004803 - transposase activity [Evidence IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="WP_000199136.1"
                     /translation="MTRYEENFKQMIVELNQTGRSVRGLAKEYGLSEATIYKWKNLYLP
                     DQSTGLTGKEVAELRKENARLNEELEILKKAAAIFSRKT"
                     /name="transposase"
     gene            complement(7618..7893)
                     /gene="prgO"
                     /locus_tag="EQB65_RS17125"
     CDS             complement(7618..7893)
                     /gene="prgO"
                     /locus_tag="EQB65_RS17125"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001196543.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA segregation protein PrgO"
                     /protein_id="WP_001196543.1"
                     /translation="MALLPTNKDKKKIGAEDISIKDDINVELGERKYTAKERKPVQVDP
                     PVLKTIRDLSYAKDIPMYEIVKLAMDAYVDTLNDEERIIYNRRSKD"
                     /name="prgO"
     gene            complement(7865..8818)
                     /locus_tag="EQB65_RS17130"
     CDS             complement(7865..8818)
                     /locus_tag="EQB65_RS17130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016623100.1"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ParA family protein"
                     /protein_id="WP_000429439.1"
                     /translation="MENLRTAFKTSDKLGKVVMLTGRKGGIGKTTDNDLLAIVSSQLFE
                     KDVLLIDYDQQRNTTSNIGSTYQITSFDRSMSAAIKKGDWVSGITQVSPHLYIMAGSPG
                     SEELNEYLSEKYPDRRKRSLAFIKPLEELRKNFDYIFIDCPPSTDNVVRAFLTAADYII
                     AMQELKRYAMEGTEDFINKVLVPIVTNFEESHLQIIGILPVLFSVRRSSQHANYQKTID
                     KYGESNIFKSIVKGSDRLEMYGENGIQLNDYVDRRWWAIFADIFTELEERIEYYEQHGD
                     IEGFDYTPKYADSMANHILPLGKEIKLNGIITNEQR"
                     /name="ParA family protein"
     gene            9430..10923
                     /locus_tag="EQB65_RS17135"
     CDS             9430..10923
                     /locus_tag="EQB65_RS17135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000947690.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="primase C-terminal domain-containing protein"
                     /protein_id="WP_000947691.1"
                     /translation="MLSEIYSAILKNGLRTYKYRNSTMKPAGHIDSSRSGAIFAYRSKQ
                     LMNVGRGMVITSEEAILENEKKLTHWTPNTYRFGTYADDYRTVVKGHSEKNLSQINTFV
                     VDIDSKENHQGEIILACLDQVGYMPTLILESDHGYQVYFVLKTPGYVTKKSNFKVIDVA
                     KKISKTIRLQLAEKLSGVDLGCNHFGIARFPQENNIVFKEMNYQYSFADWIQWSMKLES
                     DQKTKEDRERKLIVFPEKKEIRQVDEPWFDMLLHKANIVGGEGRLGRNNVIFTLSLAYY
                     SSGYALDTCEYNMFTFNERLQEPLSEAELVKIVRSAYSGNYQAASREFIIELCQQWVSP
                     TLKNNDLFIQRRGWWKFKKPRDQRKYSHKNEWKEDLLAYLSEKSLASEPYLNLSKKELA
                     SQLTMPKRTLDKILNELREENKVFYKVTRGRNGGMIIASVKTLFARVIQLSKEKRLDYS
                     TRITEVFGLNESLVEETFRQLSTPLNPLKEVNLFEVDTG"
                     /name="primase C-terminal domain-containing protein"
     gene            11058..11354
                     /locus_tag="EQB65_RS17140"
     CDS             11058..11354
                     /locus_tag="EQB65_RS17140"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000053907.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication control protein PrgN"
                     /protein_id="WP_000053907.1"
                     /translation="MSLKNYVYSHPVNVFIIGRLGLSVEVFCELYGFKQGTLSSWVTRE
                     KTVASLPIEFLHGLSLASGETMDQVYDCLCVLEQEYIEYKIANELRKRKKYIQ"
                     /name="replication control protein PrgN"
     gene            complement(11378..12337)
                     /locus_tag="EQB65_RS17145"
     CDS             complement(11378..12337)
                     /locus_tag="EQB65_RS17145"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002339652.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS30 family transposase"
                     /protein_id="WP_002287225.1"
                     /translation="MTYTHLTTDELVMIESYFKINQSVAKTAHFLNRSRQTIHKVYLFF
                     KQGKSALEYYQQYKKNKSNCGRRPLVLPEEQSEYIQRKVVQGWTPDVIVGRAAFPIRCS
                     ARTIYRMFKKGLFNPSDLPMKGKRKPNGHQERRGKQAFRRSIHEREKDYSQFSNEFGHL
                     EGDTIVGLKHKSAVITLVERLSKVIITLKPCGRQAIDIENKLNHWFESVPKNLFKSITF
                     DCGKEFSNWKQISNANDIAIYFADPGTPSQRGLNENSNGLLRRDGLLKSMDFNSVDESF
                     IQSVASKRNNIPRKSLNYRTPLEVFLSYVSIDDLSNLI"
                     /name="IS30 family transposase"
     gene            12520..13371
                     /locus_tag="EQB65_RS17150"
     CDS             12520..13371
                     /locus_tag="EQB65_RS17150"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002338002.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002287227.1"
                     /translation="MKSDDWIEHTWLPLKRNSKRKKFWVLQLWPLGKLCSYGARLILDL
                     TVYSIGVFGTAYYLINDPNRIAASDIFTVLMTLIFVMLLSIFTQLVMQFTRQKLTAGKL
                     FKSLFDLIVVNAILATLIKQIEQSGRTTKGVKDFLLTFIHFVNGHMYLFEVGIILFFVG
                     YVSTKLIKRSIEKEIEIDLIPTLLGYEYNVDFGRYDELINTDIVHTSIHESTVKGIRSI
                     LKNGQEMKAIDRRKEIYNFYEVEASLRYGIGKLWLDGSNIRQNKPYIFWNSSDLELPMK
                     DK"
                     /name="hypothetical protein"
     gene            13392..13604
                     /locus_tag="EQB65_RS17155"
     CDS             13392..13604
                     /locus_tag="EQB65_RS17155"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002324171.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002324171.1"
                     /translation="MIPLYRIVLIVGMELKTLKKEQLFKVKERHNQLLCSKTGTMNIEY
                     RTEYLELTNQTDFLLIRKQQEQEKN"
                     /name="hypothetical protein"
     gene            14037..14717
                     /locus_tag="EQB65_RS17160"
     CDS             14037..14717
                     /locus_tag="EQB65_RS17160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="WP_001015311.1"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            complement(14740..15639)
                     /locus_tag="EQB65_RS17165"
     CDS             complement(14740..15639)
                     /locus_tag="EQB65_RS17165"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002352499.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protein rep"
                     /protein_id="WP_127840797.1"
                     /translation="MCPNSSIYSDEKSRVLVDKTKSGKVRPWREKKIANVDYFELLHIL
                     EFKKAERVKDCAEILEYKQNRETGERKLYRVWFCKSRLCPMCNWRRAMKHGIQSQKVVA
                     EVIKQKPTVRWLFLTLTVKNVYDGEELNKSLSDMAQGFRRMMQYKKINKNLVGFMRATE
                     VTINNKDNSYNQHMHVLVCVEPTYFKNTENYVNQKQWIQFWKKAMKLDYDPNVKVQMIR
                     PKNKYKSDIQSAIDETAKYPVKDTDFMTDDEEKNLKRLSDLEEGLHRKRLISYGGSLKE
                     IHKKLNLDGFCCKVLNKE"
                     /name="protein rep"
     gene            complement(15884..>16336)
                     /locus_tag="EQB65_RS17170"
                     /pseudo=""
     CDS             complement(15884..>16336)
                     /locus_tag="EQB65_RS17170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001619005.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid recombination protein"
                     /name="plasmid recombination protein"
     gene            complement(16392..17072)
                     /locus_tag="EQB65_RS17175"
     CDS             complement(16392..17072)
                     /locus_tag="EQB65_RS17175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="WP_001015311.1"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            complement(<17745..17927)
                     /locus_tag="EQB65_RS17185"
                     /pseudo=""
     CDS             complement(<17745..17927)
                     /locus_tag="EQB65_RS17185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002313295.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /name="hypothetical protein"
     gene            complement(18127..19116)
                     /locus_tag="EQB65_RS17190"
     CDS             complement(18127..19116)
                     /locus_tag="EQB65_RS17190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002364959.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003916 - DNA topoisomerase activity [Evidence IEA]"
                     /GO_process="GO:0006270 - DNA replication initiation
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation factor domain-containing
                     protein"
                     /protein_id="WP_127840798.1"
                     /translation="MLYLKLCNRTKKGIIVNEWEKLNRISNRRLSVDDKVHPLKLSWSI
                     DRITIVGKLNDTIAYWTQNGVVFVDFEQLMRLNENQGYLKSVGTNGWQLFDQYGEDIAY
                     IEMLKFHPDKGRIDFNPNKIGEFLKGSMKQFIHDLFLDAHFSRADIACDILGVPDDFIT
                     QYRIVDPVSFKPIYGRSGKLETAYWGSRASERQVRMYNKKLEQERKKQIVPKEIETWWR
                     IEMQLRRGKATDWHAMVRESLDSFASPHYLPGDVKPVDRIMIKGLNQDHSEWAYISRNL
                     KYRLRKLLKEESQNDELTNHLRETFKESANDLKIELDTWLLGLDVTEK"
                     /name="replication initiation factor domain-containing
                     protein"
     gene            complement(19141..19821)
                     /locus_tag="EQB65_RS17195"
     CDS             complement(19141..19821)
                     /locus_tag="EQB65_RS17195"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="WP_001015311.1"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     Typing          9431..10923
                     /name="rep_cluster_185"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.866"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(14773..15660)
                     /name="rep_cluster_1018"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.888"
                     /coverage="88.0"
                     /evalue="0.0"
     Typing          complement(18128..18894)
                     /name="rep_cluster_1968"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 ctccattcat aaaataatca acatatttaa aaaatctaat tagctttttt agtcaatcta
       61 aagttcttta ttctatgata taatgttact gtagaaagtt tgtggcggtt tggcaaatcc
      121 aattgaagga gcgtggtgcc tatgggctta ttagcttatc ggacgtactc tgtagaaagg
      181 aaatgcctga tttgttctca ttggatcaaa tcattgctat tatcggagca gcagcagtag
      241 ttattactgc cgtagcgaaa gctagcgatt cgattttagc ttggttaaag ttcaaaaaag
      301 aacaaaaaaa atagagccgt ctcaactttt ggcgaggtag acgagctcta aagctttatt
      361 tacatgccat ccgctttgaa cggactacac tgggcatgtg acagcatgcc ctttcattta
      421 tattatatct cattctttta tataatgaaa gtaaataaat catggaggat aaaatatgga
      481 taaatttaat agattaacat taataaatca gtttgaaatt ttaaaagctt taaatcctaa
      541 cgaagaaaaa tactatgctg aaaaaataga aatactaaca gaaggttacg aatatcacta
      601 tagtgaaata tttgaaaata tttctgatcc attgccagaa gaagattcgc ggtttgttct
      661 agacatatta aatatgtata gagatattac ttttagtaaa aataaattaa aagatataaa
      721 ttcaattgat aattattata tacaatttaa aggttttgac tttaatagct ctaccgaatt
      781 taagttagca ctttatgcac aattttttat tgaaaaatta aataggtttc aagaaatagt
      841 tgaagatagt gattttaaca cttttaatag ccataaaccg atgagaggta cttatataaa
      901 atttctcgaa aattataatg atttaaaatc taccaataat tatcaatttg gaaacttgtc
      961 ttatgagatg ataagtaaag ttctaagttt gtgatgataa atgaaattaa atagtataaa
     1021 tgatttattt gctattatag gtgttattgc taacatactt ttttcgtgtt tgaattttag
     1081 atttactcaa aagaacaaaa agaacaaact cagtatagaa caaatgaaaa aagacattga
     1141 aactgattta aaaaatgacc ataaagaaag aagaaaaatt gaagaatata cttctttaat
     1201 ggaaaagtgt aaagcaactg atgcaatttt tagcttttta agaaaaagtg atgagataat
     1261 cacacgtgaa aatatagatt tagaaaatga gattagtaaa cttgaatcta tcttttccga
     1321 tataaattct cttaagtatt taatcgtcga agaaaattcg gatagctttt tagaatttga
     1381 aaaatatcta acagatctta tagataatag aaataatgaa ttaatgagac aaaacattgc
     1441 aagattcctt actaaattag tttctgaatg gaaaagtatt atttctcaaa atatggataa
     1501 attaagatat taaggatgtt agttttaaaa taaactaatg tccttatttt tgtgttcaca
     1561 tttctgttac ctaagaaata cttaaaggag gtgatgtagc cagcaacgac tacaacttga
     1621 acccgctatc tacagtttat ttgttgtttc ttttgggtat actctaatgg tacaaatcca
     1681 tatttgctta aagcgttgat ttttcagcgg tttttcttta ttgcaaagtg taccctaaga
     1741 cctgtatact aatagtaaat agattggata ggaatgatgg caaatgtatt tagcttattt
     1801 aagagtttct tccgacgatc aaagtttagc tcggcaacat aagctaattg aaaattggtc
     1861 agtcaaaaat aatattgctg aagacgattt aaaaattttc gaggaaaaag tctctggaaa
     1921 aaatattgaa aacagaccag agctgcaaga gcttatttct ttcatacgtg aacgagatac
     1981 gattattatt cctagtcttg atcgattagc aagaaatagt aaagatacaa aagacttact
     2041 tcaattgttt cgtagtaaag gtgcttctat tgaaatatta gacctaccgt cgtttaatgg
     2101 ggtaactgac cctgcattaa gagacttgct aacaaattta gtcatagaag tgtttagcta
     2161 tgttgctgaa aacgaacgga aaaaaatcaa agagcgtcaa aaacaaggca ttgaaattgc
     2221 aaagaaaaat ggtcgttata ctggtaaaaa gattcaatac catgccaatg caacaggaaa
     2281 aaacaaattg atttacgatg aaattgttga tggttctgtt gcaaagtttt aaatctacta
     2341 tcaaataagg tagaataata gaaaaagata gcaggaggaa tgacgatgaa tcattttaaa
     2401 ggaaagcaat ttcagcagga tgtgattatt gtagccgtgg gctactatct tcgttataac
     2461 cttagctatc gtgaagttca agaaatctta tatgatcgtg gcattaacgt ttctcatacg
     2521 acgatttatc gttgggtgca agaatatggc aaactactct atcaaatttg gaaaaagaaa
     2581 aataaaaaat ccttttattc atggaaaatg gatgaaacgt acatcaaaat taaaggaaaa
     2641 tggcattatt tgtatcgagc catcgatgca gatggtttaa ccttggatat ttggttacgt
     2701 aaaaaacggg acacacaagc agcctatgct tttcttaagc ggttagtgaa gcagtttgat
     2761 gaaccgaagg ttgtagtcac agataaagcc ccctctatta caagtgcctt taagaaacta
     2821 aaagaatacg gcttttatca agggacagaa catcgtacca ttaaatacct gaataatttg
     2881 attgaacaag accatcgtcc agtaaagaga cgcaataaat tctatcgaag tttacgcact
     2941 gcctctacca cgattaaagg catggaagcc attcgaggat tatataagaa aacccgaaaa
     3001 gaaggcactc tcttcgggtt ttcggtctgt actgaaatca aggtattatt gggaatccca
     3061 gcttaaatca tagataccgt aagggatttt attctttatt taaaactttg caacagaacc
     3121 aactagactg tgcaaaatag agacacttga aaaatctatc gggggtcaga aacttaatag
     3181 tttttgacac ataaacaaaa tcgcgatata atggggttga gagtgtttca taaacttatg
     3241 tcataaagtt aaggagattt cgcatgattt tagagaataa attgggatta accaatcaag
     3301 ttgagttggc taaggttgaa gaaaaactca gtaaacaaaa agcgaaagaa ttgtacgatt
     3361 gtggaaaaat aaatgaaatc gaagttggta catttaaagg tttatctgaa attcatgaat
     3421 ttctattttc ggatatttac gattttgccg gaaaaatccg atcggtcaat attgcaaaag
     3481 gaaattttcg atttgcacca gttatgtatt tagaacattc gttacagcat attgatcaga
     3541 tgccacaaac ttcttttgaa gagattatca agaaatatgt ggagatgaat atcgctcacc
     3601 catttcgaga aggaaatggc cgaagtacta gaatttggct ggatctcatt ttaaaggaag
     3661 aattgcaaaa agttgtagat tggaacttaa tcgataaagc agactatctt tctgcaatgg
     3721 agcgaagtcc cataaacgat ttggaaatac gctatctaat ttccaatgct ctgactgata
     3781 aaattgacga tcgcgagtta tatatgaaag gaatcgatgt cagctatttc tatgaagggt
     3841 attctgagta tacgatagat gatttgtaaa agtaggtgga ccaaatgacg aaatatggat
     3901 atgcacgtgt ctcaaccgct tctcaaagta caaaagaaca aattcaacag ttgcttgaga
     3961 actgcgtaga gaagaagaat attttttcag aaaaatttac gggtacaaaa cgggatcggc
     4021 caaaattcaa tcagctgttg gctggtctga agcctggaga tgaaatagtt gttacgaagc
     4081 ttgatcgatt tgctcgtaac acgagagaag cattagagat cattgaacct ttactcgatg
     4141 ataacgtaac gatcaaggtt ttgaatctag gaacgattga aaatacgtcc atggggcgaa
     4201 tggtgacacg gacgttgttg agtgtagcag aaatggaacg tgatatgatt gtggaacgta
     4261 cccaagaagg aaaaatgttt gcaagaaaga ataatcctaa tttcagagaa ggacgtccga
     4321 aagcaacaat cacaccgaag aagaggcacg catatgaact gcttacttca ggtaaatcgt
     4381 ataaggaagt tgaagctata accggtttca gtcgcagtac gctttttaga ataaagaaga
     4441 aaattgaaga aagttaaaaa agaagtctca gcgaaccaga caggtaaata cttaatgcgt
     4501 tctagatatg agtctattag catgttgtga aatataatat ttttttattt acttgatttc
     4561 tgctcaaaaa atgtgtatgg taactgtaaa aggtaaagta attaaaggta tgctagccac
     4621 gcttactata ttaggatacc atcatatatt tataatgaac gatttgttcg tctaccaaac
     4681 aacacatatc gttcagcgta agtcacgttt aggaacgtgg cttttttagt gttattatcg
     4741 ataaataatc tattgactct attgatttta tctccatatc cctacggtgt tgattgtctt
     4801 tagatctttc atttaagaac caaataacta tcataaaaat cagcactgct gctaatataa
     4861 taaacagcat tcctattgtg atattactgg atttgagtca atatcttgga cacattttag
     4921 tagagacggt taagccattt tttcttttgc taattcttca aattcctgtg gggttagata
     4981 gtgaatcgag ctatggattc gatttcggtt ataaaatcct tcaatgtagc taaatagcgc
     5041 tcgatttgct tcttcaaaat ctgagtagct agtcgtgtag acttcttctt ttttcaatga
     5101 ggcatggaaa gattcgattc cagcattatc ataaggtgtt ccttttctac tataagaatg
     5161 ccttattttg ttggttttaa gccattgttc cacttctctt gctgtgtatt ggctgcccaa
     5221 gtcagtgtgt agaatcattc cttctggaat gtgataatgt atttttgctt tattcaatgt
     5281 ttgaatgaca caatccacag tcattcgttt tgaaaatgta taactaataa ttcttttcgt
     5341 gtgtaaatcc atgattgaag ataagtaaca ccaaccattt ttcttagtag gaatgtacgt
     5401 aatgtcagct gcccatttct cacagatcgt ttcagtagaa aagtcctgat ttaagagatt
     5461 ctcttttgaa atgatggaat ggcaacagtt tttttgacaa attttataag gtgcagaact
     5521 tctttccgta tgctattccg attgtccttg acaatgagcc tcctcggatg tgacgatctt
     5581 cggcaggagc taacagttaa agttagactg cctcgctagc gttagcacat ccgagctcat
     5641 tatcaaggat tcgctgcgcc aatctctggt tacggtaacc aaccggtgtc tcgtagccaa
     5701 gtgtaccgtg caaccgaagg tggttccacc aattgacata gtcaaataac tccaaatcca
     5761 attgttgtaa ggtttcaaat gtgtattgat agacaaattc tactttcaac gacttataag
     5821 ttgattcagc tacggcatta tcaaaaggac agcctttatg actcaatgat cgattgatgt
     5881 caaaagttgt taataattca tcaatagctt ggttatcaaa ctcttttcca cgatcagtat
     5941 gaaaaatctc aacctctgtc agaggttgtt tgatacggct aaatgctttt tttactagaa
     6001 cggcatcttt atgttctcca caagaatagc cgagaatttc tcgattgaac agatccaaaa
     6061 tgaaacagac ataattccat tttttcccga ctcgtacata agtcaagtct gttacgatcg
     6121 cttctaatgg gttgtctctt aagaatttac gattcaatac gtttgtcgtt ttggcttcat
     6181 tgcaagtaga atgatgtact ttaaaataag caacagtata gctcgatttt aatcctctat
     6241 ttttcatgat tctactaatt tttcgtcggc tgatctgaat gcctcgtttt gataaggctt
     6301 tttttatttt tcttgagccg taggcctttc ggctgcggat aaattcttca gcgactactt
     6361 cttcaagttc tgattcgtct ttctttggtt ttgattgata ataataggac tgacgtgata
     6421 gacctaatat tctgcacatc gctgatatag ggtaaagatg cttattcgca tcgattactt
     6481 gtctcttcgt ccgaatatca gcgctgcttg ctttaaaata tcattttcca tttctaattg
     6541 ctggtttctt ttacgtagtt ctaacaattc tttttgttca ggcgtaagat tatctttttc
     6601 tttgaatgaa ccactcgttt taaattgctt tacccatttg tcaaatgctg aagccgttag
     6661 ttcatattct cgaatgattt ctacacgtgg ctttccagct aagtaaagat tgacgatttg
     6721 ttgcttgaat tcttgtgaaa aagttcttcg tgttctctta gacataaaaa ttcctcctgg
     6781 tatgttttct tctagtctac acaccttaat ttttctgtct agttaattgt agcctatcca
     6841 tgatcggttt attagacctt tgaggtctat attttttaac tacaatcgac cttaaattta
     6901 attgtttcat tagcttttgg acatgtttaa gagatactga aatcccttct tttaataaaa
     6961 cttgatggat ctttgtggca ccatagcgtt gtttattcgt aaaaaaaatt gttgaaatct
     7021 tctttttcaa cttattattt ctgatttctg tagctgtcaa cggtttattc ttataaaaat
     7081 aatagacact tctagggatt tctaataacc gacacaacaa agaaacagtg taatccttac
     7141 accatttttc aataaattga acaagcgaat ttaggttttc cgagagaata tggctgcggc
     7201 tttttttaag atttcaagtt cctcatttaa acgagcattt tcttttctca gttcagctac
     7261 ttcttttcca gtcagtcctg tggactgatc aggtaaatat aaattcttcc atttgtaaat
     7321 cgttgcttca gataagccat attctttcgc taaccctcga acagaacgtc cagtttgatt
     7381 cagttcaaca atcatttgtt taaaattttc ttcatatcgg gtcataaaaa ttcatcctct
     7441 cgtagataag tttaatttat tcttgtctct acgaaaagct gtctaagatt tgatactaac
     7501 accaaatgtt gtataccccc aaacaataca catattttga aggattagga ttaataaagc
     7561 taaaaatata gtaagtatac taaatatatt tactatatct agtatactta ctatatttta
     7621 atcttttgat cgtctattat atataatccg ttcctcgtcg tttaaagtat caacataggc
     7681 gtccattgca agtttgacta tttcatacat aggaatatct tttgcataac taagatcccg
     7741 aatggttttt agtacgggag gatctacttg aactggtttt ctttctttcg cagtgtactt
     7801 tcgttcccct aactcgacat taatatcatc tttaattgaa atatcttcag caccaatttt
     7861 cttcttatct ttgttcgttg gtaataatgc catttagttt aatctccttt ccaagaggta
     7921 ggatatgatt ggccattgag tcagcatatt taggtgtata atcaaatcct tcaatatcac
     7981 catgttgttc atagtattca attctttctt ctaattctgt aaagatgtct gcaaaaatag
     8041 cccaccatct tcgatctaca taatcattta attggatacc attctcacca tacatttcta
     8101 accgatccga gcctttaaca atgcttttaa aaatgtttga ttcaccatac ttatcaattg
     8161 ttttttgata gtttgcgtgt tgagaggaac gtcgcactga gaaaagaaca ggcaaaattc
     8221 caatgatttg aagatgagac tcttcaaaat tcgtgacaat cggaactaaa actttattaa
     8281 taaaatcttc tgttccttcc attgcgtacc gttttaattc ttgcattgca ataatataat
     8341 ctgcagcagt taagaatgca cgaaccacat tatctgttga tggtgggcag tcgataaaga
     8401 tataatcgaa attttttctc aattcttcta aaggtttaat gaaggccaat gatctcttac
     8461 gacgatcagg atatttttcg gacaagtatt cattaagttc ttcagatcca ggagagccag
     8521 ccataatata taaatgtgga cttacttgag taatacctga aacccagtcc ccttttttga
     8581 ttgctgcaga catggatcga tcaaagctag taatttgata cgttgatcca atgttggaag
     8641 tagtatttct ttgttggtca taatcaatta gcaacacgtc tttttcaaaa agttgactag
     8701 aaacaatcgc taataaatca ttgtctgtag tcttaccaat gccgcctttt ctacctgtaa
     8761 gcattacaac ttttcctagt ttatctgatg ttttaaatgc agtccgtaag ttttccatag
     8821 ttccctccaa tttcctatac taaatatatt tagtatactt catatactta atatattcga
     8881 tatatctaat atactccaaa ttgataagaa ttcagacttt ataaggaata tagtggatat
     8941 actaaatata tttgctatat tcagtatatc agatatattc aaaatgtcaa aatatatttg
     9001 tgcgttttgc gttgacaatt tagagtgaaa agaggtaaac ttaattctat agaaaccaca
     9061 gataattcac tatttacaaa gtagcaaaag cagtggtact ctttaaacag aaaaattaca
     9121 taaaaaaaag agacggaaat aattgatttt agcagaatca attatttctg aatcacatgg
     9181 ttaggacatg tgttcacgct cgtctcaaga atatgtaagt agctaccaac tacttatatt
     9241 aaaagttgat cggatacctt ttccgattgc ctttattcta ccaaaaaaag gcgagcaact
     9301 caacagaaga acgtttattt agtgtactta aattaaatat tcttaaacac tgaagagaga
     9361 acacatacta tggctgagat taaagctaaa ctgtgttctc tttttgtttg agaaaggacg
     9421 ttacaatcga tgttgagcga aatttattca gctattctta aaaacggctt acgtacatac
     9481 aaatatcgaa acagcaccat gaaacctgca ggtcatattg attccagtag gagtggtgct
     9541 atctttgcgt accgtagcaa gcaattaatg aatgttgggc gtggtatggt cattacttcg
     9601 gaagaagcta ttttagagaa cgaaaagaaa ctaacgcatt ggacacctaa tacctatcgc
     9661 tttggtactt atgcggatga ttatcgaaca gtggttaaag gtcattctga gaaaaactta
     9721 agtcaaatca acacatttgt agttgatatc gattcaaaag agaaccatca aggcgaaatt
     9781 attttagcct gtttagatca agtgggctac atgccaacgc taattttaga atcagatcat
     9841 ggttatcaag tttattttgt actaaagaca ccaggctatg tcacaaagaa aagcaatttc
     9901 aaggtgatcg atgtagcaaa aaaaatttca aaaacaattc gtctacagtt ggctgaaaaa
     9961 ttgtccggag tggatctagg atgtaaccac ttcggaattg ctcgattccc acaagaaaat
    10021 aatattgttt ttaaagaaat gaactatcag tattcttttg ctgactggat tcaatggtcg
    10081 atgaagcttg aatcagatca aaaaacaaaa gaagatcgag aacgaaaact aattgtcttt
    10141 cctgagaaaa aagaaattcg tcaagtagat gaaccgtggt tcgatatgtt acttcataaa
    10201 gcaaacatcg tcggcggaga aggacgtctt ggtcgaaata atgtgatttt cacgctttct
    10261 ttagcttatt actcttcagg ttatgcattg gatacttgcg aatacaatat gttcacattc
    10321 aacgaacggt tacaggaacc gctatctgaa gcagaattag taaagattgt acgtagtgct
    10381 tattctggta attatcaagc agcaagcaga gaattcatta ttgaattgtg ccagcaatgg
    10441 gtttcaccaa ccttaaaaaa taatgatctg ttcattcaac gacgtggctg gtggaaattt
    10501 aaaaagccac gagatcaaag aaaatatagt cataaaaatg aatggaaaga agatctattg
    10561 gcttatctaa gcgaaaaaag tcttgctagt gagccttatt tgaacctgtc aaaaaaagaa
    10621 ttggcttcac aactaacgat gcccaagcga acacttgata agatcttaaa tgagttacga
    10681 gaggagaata aagtcttcta caaggtaaca cgaggaagaa atggcggaat gatcattgct
    10741 tcagtcaaaa cgttgttcgc gagggttatt caactaagta aagaaaagag actagattat
    10801 tcaacaagga tcacagaggt atttggactc aacgagagct tagtagaaga gacatttaga
    10861 caattatcaa cccccttgaa ccctcttaaa gaagtgaatc tttttgaagt agatacaggt
    10921 tgaaaaataa aaggtgcaaa ttgccttata caatatatct atgatacttc tgtaggtgtt
    10981 gctccctttg cctagctacg tgtaggtggt atacttataa ctgcgtatgc agtcttatgt
    11041 atcatggagg aagttgtatg tcgttaaaaa attatgtcta ttcacatcct gttaatgtgt
    11101 ttatcattgg tcgtttggga ttatctgtgg aagtgttctg tgagctttat ggttttaagc
    11161 aggggacttt gtcttcttgg gttaccaggg aaaaaacagt tgcttctttg ccgattgagt
    11221 ttcttcatgg gttgtcctta gcttctgggg agactatgga tcaggtatat gattgtttgt
    11281 gtgtgttaga gcaggagtat attgagtata aaatagctaa cgagttaaga aaaaggaaga
    11341 agtatatcca gtagtagttt ttatttactc ttaattgtca aattaagtta gacaaatcat
    11401 caatacttac gtaactcaaa aatacttcca aaggtgttcg ataattcagt gattttctag
    11461 gaatattatt tcgtttcgat gcgacagatt gaataaaaga ttcatctact gaattgaaat
    11521 ccatagattt caataaacca tctctacgta acaatccgtt agaattctcg tttaggcctc
    11581 tttgagacgg cgttcctgga tcagcgaaat aaatggcaat atcattggca ttactgatct
    11641 gtttccaatt tgaaaattcc tttccacaat caaaagtgat ggatttgaat agatttttcg
    11701 gtacagattc aaaccaatga tttaatttgt tttcaatatc aatcgcttgt ctaccacacg
    11761 gtttcaatgt gatgataact tttgataatc gctcaactaa ggtaattaca gcacttttat
    11821 gtttcaaacc tacgatagtg tcaccttcaa ggtgaccaaa ctcatttgag aattggctat
    11881 aatctttttc acgttcatga atagagcgac ggaaagcttg ttttccacgt ctttcttgat
    11941 gtccatttgg tttacgcttg cctttcatcg gtaagtcaga aggattaaat agcccctttt
    12001 tgaacatacg ataaatggta cgagcagaac aacgaatagg aaacgctgca cgaccaacaa
    12061 tcacatcggg tgtccatcct tgaacaacct ttctttgaat atattctgat tgttcctcag
    12121 gtaaaacaag cgggcgtcta ccacagtttg atttgttttt cttatactgt tgatagtact
    12181 ctaaggctga ttttccttgc ttgaagaaca ggtatacttt atggatcgtt tgtcttgaac
    12241 gattcaagaa atgcgcagtt ttcgcaacag attgatttat tttgaaataa gactctatca
    12301 ttacaagttc atccgttgta agatgggtat aggtcatttg tactcactcc ttataattct
    12361 ttggacggaa ctattttgag tgtagcacaa atgacttttt tagttgtcta gcttaatttt
    12421 acaatcggcg tacttaaaaa attggttcat tgagcaacct atcgctgcta aagtagcaaa
    12481 ggaaaacgtt aaaggaaaga atttagggaa gaaatcgaaa tgaaatcgga cgactggatt
    12541 gaacacacct ggcttcctct gaaaagaaat agcaaacgaa agaaattttg ggtattgcaa
    12601 ttatggccat taggaaaact ttgtagttac ggggcacgac ttattcttga tttaaccgtt
    12661 tactcgattg gagtatttgg aacggcttat tacttgataa atgatcccaa taggattgca
    12721 gcatcagaca tttttacagt gctaatgacg ttgatttttg tcatgctatt gtctattttt
    12781 actcaattag tcatgcaatt taccaggcaa aaattaacag caggaaaact tttcaaaagc
    12841 ctattcgatt taattgttgt aaatgcaatt ctagcgactt taataaaaca aattgaacaa
    12901 tctggaagaa caacaaaagg agtgaaggat tttttattga cgtttattca ctttgtaaat
    12961 ggacacatgt atttgtttga agtgggtatt attctctttt ttgtcgggta tgtatccacg
    13021 aaacttatta aacgttcaat tgaaaaagaa attgaaattg acctgattcc gacacttctt
    13081 ggttatgagt acaatgttga ttttggaaga tatgacgaat tgatcaatac ggatatcgtt
    13141 cacacgagta tccatgaatc tactgttaag ggcatcagat ctattttaaa aaatggccag
    13201 gaaatgaaag caatagatcg aagaaaagag atctacaatt tttatgaagt cgaagcaagc
    13261 ctacgatatg gcatcggaaa attgtggtta gatggaagta atattcgtca aaacaaacca
    13321 tacatttttt ggaacagtag tgatttagaa cttccaatga aagataaata attatggaga
    13381 atcgtttgaa aatgattcct ctatacagga ttgtgcttat agttggcatg gagttaaaaa
    13441 ccttaaagaa ggagcagtta ttcaaagtga aagaacgtca taatcagtta ctatgtagta
    13501 aaacgggtac gatgaacatt gaataccgaa cagaatattt agaattaacg aatcaaactg
    13561 attttttgtt gattcgaaag caacaagagc aagaaaaaaa ttaatggcta cttatagcca
    13621 attgattgat gaatgggaac aattcaagga atctaaaatt ccagaacgtc tctaaaagcc
    13681 tttatttgta aagagcataa ggaaacgtgg gaacactttt taaaaaaagt gttccaatag
    13741 gctgtgccta ttacgtttct caaaaataaa tgtgggaaca aaatatttaa aaataggata
    13801 gtgaaaggat agtgaaggat agtaaaagga gggtagtagg atagcaaaaa ggataggctc
    13861 cttttcgcta tcctttttaa attggaggaa ttaatatgga agtaagaata agaaatgtgg
    13921 atgagaaaat cgtaagagaa attgatcgaa gatgtgacga acggttctgt tgcaaagttt
    13981 taaatctact atcaaataag gtagaataat agaaaaagat ggcaggagga atgacgatga
    14041 atcattttaa aggaaagcaa tttcagcagg atgtgattat tgtagccgtg ggctactatc
    14101 ttcgttataa ccttagctat cgtgaagttc aagaaatctt atatgatcgt ggcattaacg
    14161 tttctcatac gacgatttat cgttgggtgc aagaatatgg caaactactc tatcaaattt
    14221 ggaaaaagaa aaataaaaaa tccttttatt catggaaaat ggatgaaacg tacatcaaaa
    14281 ttaaaggaaa atggcattat ttgtatcgag ccatcgatgc agatggttta accttggata
    14341 tttggttacg taaaaaacgg gacacacaag cagcctatgc ttttcttaag cggttagtga
    14401 agcagtttga tgaaccgaag gttgtagtca cagataaagc cccctctatt acaagtgcct
    14461 ttaagaaact aaaagaatac ggcttttatc aagggacaga acatcgtacc attaaatacc
    14521 tgaataattt gattgaacaa gaccatcgtc cagtaaagag acgcaataaa ttctatcgaa
    14581 gtttacgcac tgcctctacc acgattaaag gcatggaagc cattcgagga ttatataaga
    14641 aaacccgaaa agaaggcact ctcttcgggt tttcggtctg tactgaaatc aaggtattat
    14701 tgggaatccc agcttaaatc atagataccg taagggattt tattctttat ttaaaacttt
    14761 gcaacagaac ccatcaaggt ttaatttttt atgtatttct tttaacgaac caccatagga
    14821 gattaacctt ttacggtgta aaccttcctc caaatcagac aaacgtttca aattcttttc
    14881 ttcatcatcg gtcataaaat ccgtatcctt tacaggatat tttgcagttt cgtcaattgc
    14941 cgattgtata tccgatttat atttattttt cggtcgaatc atttgaactt ttacatttgg
    15001 atcatagtct aatttcattg cctttttcca aaattgaatc cattgttttt gattcacgta
    15061 gttttctgta ttcttaaaat aagttggttc cacacatacc aatacatgca tgtgctgatt
    15121 ataagaatta tctttattat ttattgtcac ttccgttgca cgcataaaac caacaagatt
    15181 tttattaatt tttttatatt gcatcattcg gcgaaatcct tgagccatat ctgacaaact
    15241 cttatttaat tcttcgccat cataaacatt tttaactgtt aatgtgagaa acaaccaacg
    15301 aactgttggc ttttgtttaa taacttcagc aacaaccttt tgtgactgaa tgccatgttt
    15361 cattgctctc ctccagttgc acattggaca aagcctggat ttacaaaacc acactcgata
    15421 caactttctt tcgcctgttt cacgattttg tttatactct aatatttcag cacaatcttt
    15481 tactctttca gcctttttaa attcaagaat atgcagaagt tcaaagtaat caacattagc
    15541 gattttcttt tctctccatg gtctcacttt tccacttttt gtcttgtcca ctaaaaccct
    15601 tgatttttca tctgaataaa tgctactatt aggacacata atattaaaag aaacccccat
    15661 ctatttagtt atttgtttgg tcacttataa ctttaacaga tggggttttt ctgtgcaacc
    15721 aattttaagg gttttcaata ctttaaaaca catacatacc aacacttcaa cgcacctttc
    15781 agcaactaaa ataaaaatga cgttatttct atatgtatca agataagaaa gaacaagttc
    15841 aaaaccatca aaaaaagaca ccttttcagg tgcttttttt attttataaa ctcattccct
    15901 gatctcgact tcgttctttt tttacctctc ggttatgagt tagttcaaat tcgttctttt
    15961 taggttctaa atcgtgtttt tcttggaatt gtgctgtttt atcctttacc ttgtctacaa
    16021 accccttaaa aacgttttta aaggctttta agccgtctgt acgttcctta aggaattcct
    16081 tagtgctttc atagattaaa ctcacatcac gctttaaatc gcttatttta gactttaaag
    16141 acttgttttc ttcaagcaac tcattataat catttacatt ttcattaaat cgctctacaa
    16201 gaccactata tttttcttta acttgcccat gttctttact taatttttta tattctctcg
    16261 ccatatcagt actcatgaga tttctaacat gctgttttaa cctatcgtta tctctcgcag
    16321 cagtcactaa gtttttaggt tctgttgcaa agttttaaat aaagaataaa atcccttacg
    16381 gtatctatga tttaagctgg gattcccaat aataccttga tttcagtaca gaccgaaaac
    16441 ccgaagagag tgccttcttt tcgggttttc ttatataatc ctcgaatggc ttccatgcct
    16501 ttaatcgtgg tagaggcagt gcgtaaactt cgatagaatt tattgcgtct ctttactgga
    16561 cgatggtctt gttcaatcaa attattcagg tatttaatgg tacgatgttc tgtcccttga
    16621 taaaagccgt attcttttag tttcttaaag gcacttgtaa tagagggggc tttatctgtg
    16681 actacaacct tcggttcatc aaactgcttc actaaccgct taagaaaagc ataggctgct
    16741 tgtgtgtccc gttttttacg taaccaaata tccaaggtta aaccatctgc atcgatggct
    16801 cgatacaaat aatgccattt tcctttaatt ttgatgtacg tttcatccat tttccatgaa
    16861 taaaaggatt ttttattttt ctttttccaa atttgataga gtagtttgcc atattcttgc
    16921 acccaacgat aaatcgtcgt atgagaaacg ttaatgccac gatcatataa gatttcttga
    16981 acttcacgat agctaaggtt ataacgaaga tagtagccca cggctacaat aatcacatcc
    17041 tgctgaaatt gctttccttt aaaatgattc atcgtcattc ctcctgctat ctttttctat
    17101 tattctacct tatttgatag tagatttaaa actttgcaac agaacccctt ttttactcaa
    17161 atttagttcc tcctcaaaga aaaaagagat tgttggaaag aatttccaga gttcacgtaa
    17221 ctctaaaaat tcataaccag caatctctag tcttgaagaa acctaaaaat attcgtataa
    17281 tgaatttgag ttacggaact agtgtgatta gtttccgtaa aggtcgagaa cgtgtccagc
    17341 gttgctcgac tttatttttt tgctcttttt tctcattttc tttgattata gcactcctct
    17401 agaaaaaata aaaagacctc agggaatttc attccccgaa ccccttgagc ctcctcctgc
    17461 cgaaatagaa tggcgctgcc agcatttatt tcgttcagct atcggctaca caatctaaca
    17521 cgaccgttcc gctaccagtc gccttacagg ctccattttc gctcctctaa cgtgtttcac
    17581 cgattgtgcc gataactaaa cgaaataaac gctaaaaccg ctcagaacgc aaaatatgcc
    17641 attttagagc tattgtagaa aatgtagttt gaaatgcaat tttcttcttt cagcttttta
    17701 tttcccactt gtaaatctgc taattatttt ctaccagaca aaccattgat tttttggcta
    17761 tcagttaact cacgattatt atgagaaatg cttgtattct ttgttccctt tttgaacgaa
    17821 atactaaacc ccaagttaaa cccctccttc gcgctgtcgc taataaaaag agtgtaaacc
    17881 tttctgttac tctttgtcaa agagtaacat tttcctaatt gtgacatggc tgtcacaatt
    17941 ccaaatgctc tccgagggta ttcgctgtca caagtgacaa cgaaaaaagg agccgaaagc
    18001 gtgtcacgct ctcaactcct tttacgcttt attttgcttc acgcaaaata atcgcttatc
    18061 gtaaactcac gtcattaaac attgacgtaa atttactctc actcatctga cttttcttat
    18121 tcggtatcac ttctctgtca cgtccaaacc caaaagccac gtgtctaatt ctattttcaa
    18181 gtcgtttgca gattccttaa acgtctctcg taaatgattc gtcaactcat cgttttggct
    18241 ttcttctttc aacaatttgc gcaatctata tttcaaattt ctgctaatat acgcccactc
    18301 tgaatgatct tgattcagcc cttttatcat aattctatca acaggtttta catctccagg
    18361 caagtaatga ggacttgcaa agctatctaa actttcccga accatcgcat gccaatctgt
    18421 tgctttgcca cgtcttagct gcatttctat acgccaccat gtttcgattt cttttggtac
    18481 aatctgtttt tttcgttcct gttcaagctt tttgttgtac atccgcactt gtcgctcgct
    18541 ggcacgacta ccccagtacg ctgtttctaa tttgccagaa cggccataaa ttggcttaaa
    18601 agacacaggg tcaacgattc gatactgggt aataaaatca tcaggaacac cgagaatatc
    18661 gcaagcaata tctgcacgtg agaaatgcgc atccagaaac aaatcatgaa tgaattgttt
    18721 catcgacccc tttaaaaact cgccaatttt atttggatta aaatcaatac gacctttgtc
    18781 agggtgaaat tttaacattt cgatataggc gatatcttct ccatattggt caaataattg
    18841 ccaaccattt gtaccaaccg acttcaaata cccttgattt tcattcaaac gcattaattg
    18901 ctcaaaatcg acaaacacaa ctccattttg cgtccaataa gctatggtat cattcagttt
    18961 tccgacgatt gtaattcgat cgattgacca acttaatttt agggggtgta ccttatcgtc
    19021 aacacttaac cgcctgttag aaatacggtt aagtttttcc cactcattta cgattatgcc
    19081 ttttttggtt ctgttgcaaa gttttaaata aagaataaaa tcccttacgg tatctatgat
    19141 ttaagctggg attcccaata ataccttgat ttcagtacag accgaaaacc cgaagagagt
    19201 gccttctttt cgggttttct tatataatcc tcgaatggct tccatgcctt taatcgtggt
    19261 agaggcagtg cgtaaacttc gatagaattt attgcgtctc tttactggac gatggtcttg
    19321 ttcaatcaaa ttattcaggt atttaatggt acgatgttct gtcccttgat aaaagccgta
    19381 ttcttttagt ttcttaaagg cacttgtaat agagggggct ttatctgtga ctacaacctt
    19441 cggttcatca aactgcttca ctaaccgctt aagaaaagca taggctgctt gtgtgtcccg
    19501 ttttttacgt aaccaaatat ccaaggttaa accatctgca tcgatggctc gatacaaata
    19561 atgccatttt cctttaattt tgatgtacgt ttcatccatt ttccatgaat aaaaggattt
    19621 tttatttttc tttttccaaa tttgatagag tagtttgcca tattcttgca cccaacgata
    19681 aatcgtcgta tgagaaacgt taatgccacg atcatataag atttcttgaa cttcacgata
    19741 gctaaggtta taacgaagat agtagcccac ggctacaata atcacatcct gctgaaattg
    19801 ctttccttta aaatgattca tcgtcattcc tcctgctatc tttttctatt attctacctt
    19861 atttgatagt agatttaaaa ctttgcaaca gaaccctaaa aacactatat attccgaaaa
    19921 gtgagtat
//
