LOCUS       NZ_KX946994             8300 bp    DNA     circular CON 09-JAN-2024
DEFINITION  Klebsiella oxytoca strain H143640707 plasmid pJF-707, complete
            sequence.
ACCESSION   NZ_KX946994
VERSION     NZ_KX946994.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN14226951
KEYWORDS    RefSeq.
SOURCE      Klebsiella oxytoca
  ORGANISM  Klebsiella oxytoca
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 8300)
  AUTHORS   Findlay,J., Hopkins,K.L. and Woodford,N.
  TITLE     Complete sequence of a GES-5 plasmid from a clinical Klebsiella
            oxytoca isolate in the UK
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8300)
  AUTHORS   Findlay,J., Hopkins,K.L. and Woodford,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-OCT-2016) Antimicrobial Resistance and Healthcare
            Associated Infections Reference Unit, Public Health England, 61
            Colindale Avenue, London NW95EQ, United Kingdom
COMMENT     ##Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.5.0
            Sequencing Technology             :: Illumina
            ##Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/09/2024 01:47:53
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9
            CDSs (total)                      :: 9
            Genes (coding)                    :: 8
            CDSs (with protein)               :: 8
            Genes (RNA)                       :: 0
            tRNAs                             :: 0
            ncRNAs                            :: 0
            Pseudo Genes (total)              :: 1
            CDSs (without protein)            :: 1
            Pseudo Genes (ambiguous residues) :: 0 of 1
            Pseudo Genes (frameshifted)       :: 1 of 1
            Pseudo Genes (incomplete)         :: 0 of 1
            Pseudo Genes (internal stop)      :: 0 of 1
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KX946994.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..8300
                     /organism="Klebsiella oxytoca"
                     /mol_type="genomic DNA"
                     /strain="H143640707"
                     /host="Homo sapiens"
                     /db_xref="taxon:571"
                     /plasmid="pJF-707"
     gene            complement(490..1525)
                     /locus_tag="HTK62_RS00005"
                     /pseudo=""
     CDS             complement(490..1525)
                     /locus_tag="HTK62_RS00005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019139446.1"
                     /GO_function="GO:0009009 - site-specific recombinase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA];
                     GO:0009294 - DNA-mediated transformation [Evidence IEA]"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="integron integrase"
                     /name="integron integrase"
     gene            1684..2547
                     /locus_tag="HTK62_RS00010"
     CDS             1684..2547
                     /locus_tag="HTK62_RS00010"
                     /EC_number="3.5.2.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032490683.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="carbapenem-hydrolyzing class A beta-lactamase
                     GES-5"
                     /protein_id="WP_012658785.1"
                     /translation="MRFIHALLLAGIAHSAYASEKLTFKTDLEKLEREKAAQIGVAIVD
                     PQGEIVAGHRMAQRFAMCSTFKFPLAALVFERIDSGTERGDRKLSYGPDMIVEWSPATE
                     RFLASGHMTVLEAAQAAVQLSDNGATNLLLREIGGPAAMTQYFRKIGDSVSRLDRKEPE
                     MSDNTPGDLRDTTTPIAMARTVAKVLYGGALTSTSTHTIERWLIGNQTGDATLRAGFPK
                     DWVVGEKTGTCANGGRNDIGFFKAQERDYAVAVYTTAPKLSAVERDELVASVGQVITQL
                     ILSTDK"
                     /name="carbapenem-hydrolyzing class A beta-lactamase GES-5"
     gene            complement(2884..3351)
                     /locus_tag="HTK62_RS00015"
     CDS             complement(2884..3351)
                     /locus_tag="HTK62_RS00015"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_172689985.1"
                     /translation="MQFKRQGRRVQVLAYRGYDKEKRRAIVKMMGSIDVYSFEPSDGLI
                     ENLTDEEKTELQSYIETERQAAEKRTRQYFANSAASRIKEVADTIQGGDFEPSEAWAAD
                     TWAAIEALTKVMRKAGYPKPRKATQKAADAPMADQAGLPLGDAPEAPERGR"
                     /name="hypothetical protein"
     gene            3809..4195
                     /locus_tag="HTK62_RS00020"
     CDS             3809..4195
                     /locus_tag="HTK62_RS00020"
                     /function="plasmid mobilization"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013123520.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid mobilization relaxosome protein MobC"
                     /protein_id="WP_014454106.1"
                     /translation="MNTDESKRRRRGPAPLDATDKRGHTVSVRLNDAELARLDSQRDAV
                     QMQRGEYLRAAALHRLPPTIPEVNREAWAALARTAANLNQIAHRLNAGDALPLAEVRAT
                     LDAFRRDLIGVKHDSEDVEDESEG"
                     /name="plasmid mobilization relaxosome protein MobC"
     gene            complement(4386..4742)
                     /locus_tag="HTK62_RS00040"
     CDS             complement(4386..4742)
                     /locus_tag="HTK62_RS00040"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_228717227.1"
                     /translation="MQTLARRFVARSHGHIDLLVGQLPALGPCIAQPRRQGQSVGMLKL
                     LGRLDGAAGFPLAQPHFPVQPYPAGHDVNVILVRVLVAHCHPRRIGLVKAHALHEVSRH
                     GFPLLGAQALTGRQ"
                     /name="hypothetical protein"
     gene            4951..5634
                     /locus_tag="HTK62_RS00045"
     CDS             4951..5634
                     /locus_tag="HTK62_RS00045"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_227978814.1"
                     /translation="MTKLETVRALNDSGPQLQIVESVRTLQQSVSLMHEDLKRLPGAVS
                     TETAQTLEPLARLRQDVTQVLEAYDKVTAIQRKTLDELTQQMSASAAQAFEQKAGELDK
                     TISDLSNSLSGLETSISSMKQTAEQVADLPGNLVSAQKDMTQAANKLTEAANETRPRLW
                     RQALGLILAGAVGAMLVATGQVALNRLVPPSDVQQTADWANAIWNKATPKERELLEQIV
                     NRPAN"
                     /name="hypothetical protein"
     gene            5670..6605
                     /locus_tag="HTK62_RS00050"
     CDS             5670..6605
                     /locus_tag="HTK62_RS00050"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_227978815.1"
                     /translation="MKREGRHLSVKAGGDEAYRVTRQQDGRWLWCDRYGNDGGDNIDLV
                     REIEPGTGYAEAVYRLSGAPTVRQQPRPSEPKRQPPQLPAQGLTAREHGRDYLKGRGIT
                     SDTIEHAEKAGMVRYADGGVLFVGYDRAGTAQNATRRAIAPADPVQKRDLRGSDKSYPP
                     ILPGDPAKVWIVEGGPDALALHDIAKRSGQQPPTVIVSGGANVRSFFERDDVQAILKRA
                     ERVTVAGENEKNPDAQAKADAGHQKQAQRVAEITGREVRQWTPKPEQGKDLADMNARQV
                     VEIERKRQAEIEAESAAQAPGGYDGPSFGG"
                     /name="hypothetical protein"
     gene            6676..7557
                     /locus_tag="HTK62_RS00030"
     CDS             6676..7557
                     /locus_tag="HTK62_RS00030"
                     /function="plasmid replication"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019939541.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helicase RepA family protein"
                     /protein_id="WP_014454108.1"
                     /translation="MAINIMEAFQQEPPQLDFIWPGFLAGTVGALVAPGATGKSFWALE
                     AAMSIACSVAGGDVVNLKPQHTGRVVYLAGEDPEPALIRRVHAIGQHLNQSAREAIADN
                     LTLEPIMGKRLNVMDERHLARVVEFCADARLIVLDTLSRIHSLDENSNGDMARLVATLE
                     HVAASTGASVLYLHHVSKGSAREGQTDQQQAARGASALIDNARWCGFVAKMTEDEAKRL
                     SDRAYDRQPIGNDRRGFFVRFGVSKQNYDATPLDQWYERRDGGVLLPVELLEVPNGKKA
                     GSFQKGGDDERW"
                     /name="helicase RepA family protein"
     gene            7544..8290
                     /locus_tag="HTK62_RS00035"
     CDS             7544..8290
                     /locus_tag="HTK62_RS00035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009363660.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATPase"
                     /protein_id="WP_172689986.1"
                     /translation="MSGGNAVTPTSTSAQARVMLYQPSQRPRLRSGDWTETSFGRCRIE
                     GRLGQRHADVVESILYCAEKRRDVSDGGIELLVDPARVRKTLSDSRYSHERLWSILREC
                     MGAVIEVETPTFRVLGHLIDQVVESPMTRRNPLTGDDRPMWRVRLGMALVMLLERDLSL
                     YYDPAPIARLQYGISQAVARHILSHKIEPLGGWYIDTAIMAVAGKSGSQTMRDGRRRLK
                     EDADELKALGLILDGDRIRKKRADDA"
                     /name="ABC transporter ATPase"
     ARG             1685..2544
                     /name="blaGES-5"
                     /gene="blaGES-5"
                     /gene_name="carbapenem-hydrolyzing class A beta-lactamase
                     GES-5"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     Typing          6677..7557
                     /name="IncQ2"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          4180..6599
                     /name="MOBP"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="95.443"
                     /coverage="99.0"
                     /evalue="0.0"
ORIGIN
        1 agcggcccga tagcgtggca cagcggcccg atagcgtggc acagcggccc gaaacgtggc
       61 acagcggccc ggagtaagca ggatattcag gatattcaga tcctgcgcgg cgcagcccgc
      121 gcttggtgcg cggtctggcc ttgccatcgc cccccgcctt cggcgacccc ctccgggggt
      181 aaagggccag cggggagagg gggtggaggc cggtttcccg gcctaaaccc atcaggaggc
      241 gctttctggg ggaaccgcag aattcggaaa aaatcgtacg ctaagctaac ggtgttctcg
      301 tgacagctct ttgactaggc tttctaaggc cattctgggg tcgtctcaga aaacgggaaa
      361 aatagcacgc taaggcgcgc gacggctttt acctagcagc agtgcaagtc tgcacctgcg
      421 aggcatgaca tgcaggaggg cgctatcgac cctgagccgc catccagatg aaagcaccac
      481 aaccgtcatt cagccgggcg acaagtgcaa ggccaaggcg tccagcgggc tggaggtgcc
      541 tccggcagcg actttcagca catgcgtgta gatcatcgtc gtgctcacgt ccgaatgccc
      601 caacaactct tgcaccgttc ggatgtctgt gcctgcttgc agcaagtggg tggcgaatga
      661 gtggcgcagg gtgtggacag atacgtgttt ggcaatgcca gcctgaacta ccgctttttt
      721 tagttgccgg ttcagtcttt cctcaaacaa gtggtggcgg cgctcaacgc cggtttgtgg
      781 gtccacagac agcttggccg atggaaacac ccagaaccag gcccagctct cgcccgccct
      841 ggggtacttg cgctccagtg catgaggcag atacacgcct ccgcgccccg tggcacggtc
      901 ctgcccccac acagcgcgga cctgaatcag ctgcgcccgc aaccgaggta cgagcgccct
      961 gggcagcatc accacgcggt ccttgtcgcc cttgccgctg cgcacaatga tcgcgtggcg
     1021 gtcgaaatcc acatccttga cccgcaggcc cagcgcttcg cgcaggcgca acccactgcc
     1081 gtaaagcagg gcggccaaca gcgcttcggt gcccgccatg tgcgaaagca acgtctgaac
     1141 ctcctgcacc gtcagcacca ccggaatccg cttgcgttct ggcggccgac caatctgctg
     1201 catccacggc aattccatgc ccagcacctg ccgatacaag aacaacagcg cgttgagcgc
     1261 ctgccggtgg gtggccggcg ccacttgctt ctcggtggcg agcatggtca gaaaaccctc
     1321 gacttcagct tgccccattt cgcgcggatg tcgaaaccca ccatggctgc gggccgtcca
     1381 caacacaaat gccttggccc agtagacata agctttctcg gtctgtagaa tgcaggtagc
     1441 gaacccgttc gcgcacctga tcgagcagct tgatggatcg gggagggaac cagtcaggtt
     1501 tgtcatttct gttatacctg ttcatgcatc cagtatgatg ctttacagaa ttgatttcaa
     1561 acactttttt tgggtgccgt gcgacattgt ttaacgacca cggttgtggg tatccggtgt
     1621 ttggtcagat aaaccataag ttagacgggc gtacaaagat aatttccatc tcaagggatc
     1681 accatgcgct tcattcacgc actattactg gcagggatcg ctcactctgc atatgcgtcg
     1741 gaaaaattaa ccttcaagac cgatcttgag aagctagagc gcgaaaaagc agctcagatc
     1801 ggtgttgcga tcgtcgatcc ccaaggagag atcgtcgcgg gccaccgaat ggcgcagcgt
     1861 tttgcaatgt gctcaacgtt caagtttccg ctagccgcgc tggtctttga aagaattgac
     1921 tcaggcaccg agcgggggga tcgaaaactt tcatatgggc cggacatgat cgtcgaatgg
     1981 tctcctgcca cggagcggtt tctagcatcg ggacacatga cggttctcga ggcagcgcaa
     2041 gctgcggtgc agcttagcga caatggggct actaacctct tactgagaga aattggcgga
     2101 cctgctgcaa tgacgcagta ttttcgtaaa attggcgact ctgtgagtcg gctagaccgg
     2161 aaagagccgg agatgagcga caacacacct ggcgacctca gagatacaac tacgcctatt
     2221 gctatggcac gtactgtggc taaagtcctc tatggcggcg cactgacgtc cacctcgacc
     2281 cacaccattg agaggtggct gatcggaaac caaacgggag acgcgacact acgagcgggt
     2341 tttcctaaag attgggttgt tggagagaaa actggtacct gcgccaacgg gggccggaac
     2401 gacattggtt tttttaaagc ccaggagaga gattacgctg tagcggtgta tacaacggcc
     2461 ccgaaactat cggccgtaga acgtgacgaa ttagttgcct ctgtcggtca agttattacg
     2521 caactcatcc tgagcacgga caaatagttg acgcccgtct aacaattcgt tcaagccgac
     2581 gttgcttcgt ggcggcgctt gcgtgctacg ctaagcttcg cacgccgctt gccactgcgc
     2641 accgcggctt aactcaggcg ttgagcgact gcttacccgt ttgacggtcg gccgctcctg
     2701 gccgggagcc gaaacccaga gttggggcgt caacctgatc tatacctcaa ctgggcgtca
     2761 gtcggctcac tggcatcgcg tcagactagg gccgctttct gcattatctg acgcctaaac
     2821 gtcaaactct atggcctcaa cctgacaggc cgcatgctta gcgtacgatt ttgtccgttt
     2881 tctctaccgt cccctttctg gcgcttctgg cgcatccccc aagggcaacc ccgcctgatc
     2941 cgccatcggc gcgtcagcgg ccttctgtgt cgctttgcgg ggcttcggat agcccgcttt
     3001 gcgcatgact ttggtcagcg cctcgattgc cgcccaggta tccgccgccc acgcctcgga
     3061 cggctcgaaa tcgccccctt ggatcgtatc ggcaacctct ttaatccgac tggcggctga
     3121 gttagcgaaa tactgtcggg ttcgtttttc tgctgcctgt cgctccgttt caatatatga
     3181 ctgtagttct gttttttctt cgtctgtcag attttcaatt aagccgtctg acggctcaaa
     3241 tgaatatacg tcaatagacc ccatcatctt aacgatggcg cggcgttttt ccttgtcata
     3301 cccccggtag gcgagcacct gaacccggcg accttggcgc ttaaactgca tggcggtttc
     3361 tccgtttgac tgtgtaattg tattctagtc tgacagtcgt acgctgtcaa gtgtttgcag
     3421 tcggtttctt ttttaatacg actggcattc ttaaatgatc cttcactgtc gtattaaata
     3481 gcgattgaca ctctttcccg attccgatac tatagtggta tggtatcact tcgccccgtc
     3541 gctttgccca ccccctctcc ccgctggccc attaccgccc ttgggcggtc gggacgagag
     3601 cgcagcgagc gggccgggtg ggtggctgtt tggtgcttgc atggagatat gctattatgg
     3661 tatttgcgcg gtggtttggc agggagcaag gtgtaaccag cgcttcgctt ggttctcacc
     3721 ctccggcctt cggcctacgc ccccgctccc ttcggtcggg gggttgctgc gcgtttcgct
     3781 tcgcttcact tgctggaggg cttcgcccat gaacactgac gaatccaagc gccgccgccg
     3841 tgggcctgcg ccgctcgacg ccacggacaa gcgcgggcat accgtttcgg tgcgcctcaa
     3901 cgatgccgag cttgcgcggc tggattcgca gcgtgacgcg gtgcagatgc agcgcggtga
     3961 gtacctacgc gccgccgccc ttcatcgcct gccgcccact atcccggaag tgaaccggga
     4021 agcgtgggcc gcgttggccc gcacggcggc caacctgaac cagatcgcgc accggctgaa
     4081 cgctggtgac gcgctcccgc tggccgaggt gcgggcaacg ctcgacgcct tcaggcgtga
     4141 cctgataggc gtcaagcacg actcggagga cgtggaagat gaaagcgaag gttagccgtg
     4201 gtggcggttt tcgcggtgcg ctgaactacg tttttgacgt tggcaaggaa gccacgcaca
     4261 cgaaaaacgc ggaacgtgtc ggcggcaaca tggccgggaa tgacccccgc gaactgtcgc
     4321 gggagttctc agccgtgcgc cagttgcgcc cggacatcgg caagcccgtc tggcattgct
     4381 cgctgtcact gcctcccggt gagcgcctga gcgccgagaa gtgggaagcc gtgacgactg
     4441 acttcatgca gcgcatgggc tttgaccaga ccaatacgcc gtgggtggca gtgcgccacc
     4501 aggacacgga caaggatcac attcacatcg tggccagccg ggtagggctg gacgggaaag
     4561 tgtggctggg ccagtgggaa gcccgccgcg ccatcgaggc gacccaagag cttgagcata
     4621 cccacggact gaccctgacg ccggggctgg gcgatgcacg ggccgagcgc cggaagctga
     4681 ccgacaagga gatcaatatg gccgtgagaa cgggcgacga accgccgcgc cagcgtctgc
     4741 aacggctgct ggatgaggcg gtgaaggaca agccgaccgc gccagaactg gccgagcgac
     4801 tacaggccgc aggcgtaggc gtccgggcaa acctcgccag cacagggcgc atgaacggct
     4861 tttcctttga agtggccggg gtggcgttca agggcagcga cttgggcaag ggctacacat
     4921 gggcggggct acagaaagca ggggtgactt atgacgaagc tagagaccgt gcgggccttg
     4981 aacgattccg gcccacagtt gcagatcgtg gagagcgtca ggacgttgca gcagtccgtg
     5041 agcctgatgc acgaggactt gaagcgccta ccgggcgcag tctcgaccga gacggcgcag
     5101 accttggagc cgctggcccg actccggcag gacgtgacgc aggtactgga agcctacgac
     5161 aaggtgacgg ccatccagcg caagacgctg gacgagctga cgcagcagat gagcgcgagc
     5221 gcggcgcagg cgttcgagca gaaggccggg gagctggaca agaccatctc cgacctgtcc
     5281 aacagcctgt cagggctgga aacgagcatc agcagcatga agcagaccgc ggagcaggtg
     5341 gcggacttgc cgggcaatct ggtgagcgca cagaaggaca tgacgcaagc cgccaacaaa
     5401 ctgaccgagg cagcgaacga gacgcgcccg cgcctttggc ggcaggcgct ggggctgatt
     5461 ctggccgggg ccgtgggcgc gatgctggta gcgactgggc aagtcgcttt aaacaggcta
     5521 gtgccgccaa gcgacgtgca gcagacggcg gattgggcca acgcgatttg gaacaaggcc
     5581 acgcccaagg agcgcgagtt gctggaacag atcgtcaatc ggcccgcgaa ctagatccga
     5641 ccgcctacct tgaggcgagc ggctacaccg tgaagcgcga agggcgacac ctgtccgtca
     5701 aggctggcgg tgatgaggcg taccgcgtga cccggcagca ggacgggcgc tggctctggt
     5761 gcgaccgcta cggcaacgac ggcggggaca atatcgacct tgtgcgcgag atcgaacctg
     5821 gcaccggcta cgccgaggcc gtctatcggc tttcaggtgc gccgacagtc cggcagcaac
     5881 cgcgcccgag cgagccgaag cgccaaccgc cgcagctacc ggcgcaaggg ctgacagccc
     5941 gcgagcatgg ccgcgactac ctcaagggcc gtggcatcac ctcggacacc atcgagcacg
     6001 ccgaaaaggc gggcatggtg cgctatgcag acggcggggt gctgttcgtc ggctacgacc
     6061 gtgcaggcac cgcgcagaac gccacacgcc gcgccattgc ccccgctgac ccggtgcaaa
     6121 agcgcgacct acgcggcagc gacaagagct atccgccgat cctgccgggc gacccggcaa
     6181 aggtctggat cgtggaaggt ggcccggatg cgctggccct gcacgacatc gcaaagcgca
     6241 gcggccagca gccgcccacc gtcatcgtgt cgggcggggc gaacgtgcgc agcttctttg
     6301 agcgtgacga cgtgcaagcg atcctgaagc gggccgagcg cgtcaccgtg gccggggaga
     6361 acgagaagaa cccagacgct caggccaagg ccgacgccgg gcaccagaag caggcgcagc
     6421 gggtggccga aatcaccggg cgcgaggtgc gccaatggac gccgaagccc gagcaaggca
     6481 aggacttggc cgacatgaac gcccgccagg tggtcgagat cgagcgcaag cgacaggccg
     6541 agatcgaggc cgagagcgca gcgcaagcgc cgggggggta tgatggcccc agcttcggcg
     6601 gataagagcg cctgtcagtc ggtgtgatag accgaccgac aggctgacca tcatcaacct
     6661 gtacaggagg ccgatatggc tatcaacatt atggaggcgt tccagcagga accgccacaa
     6721 ctggacttca tctggccggg ctttctggct ggcaccgtgg gcgcactggt ggcccccggc
     6781 gcgaccggca agagcttctg ggcgctggaa gcggctatgt ccatcgcttg cagcgtggca
     6841 ggcggtgacg tggtgaacct caagccgcag cacaccgggc gcgtggtcta tctggccggt
     6901 gaagatcccg aacccgccct gatccggcgc gttcacgcca tcggccagca cctcaaccag
     6961 tcggcccgcg aagccatcgc cgacaacctg accctagagc cgatcatggg caagcgcctg
     7021 aacgtcatgg acgagcggca ccttgcccgc gtggtggagt tctgcgccga tgcccggctg
     7081 atcgtgctgg acaccctgag ccgcattcac agcctcgacg agaacagcaa cggcgacatg
     7141 gcgcggcttg tcgccacgct ggaacacgtc gcggccagca ccggggcgtc tgtcctgtac
     7201 ctgcaccacg tcagcaaggg cagcgcccgc gaaggccaga ccgaccagca gcaggcggcg
     7261 cggggcgctt cggccttgat cgacaatgcc cgctggtgcg gcttcgttgc caagatgacc
     7321 gaggacgagg ccaagcgcct gagcgaccgc gcctatgacc ggcagcccat cggcaacgac
     7381 cggcgcgggt tcttcgtgcg cttcggcgtg agcaagcaga actacgacgc taccccgctt
     7441 gaccagtggt acgagcgccg agacggcggc gtcctgctgc ctgtggaact gctggaagtg
     7501 ccgaacggca agaaagccgg atcattccag aaggggggcg acgatgagcg gtggtaatgc
     7561 agttacccct acgagcacca gcgcacaagc gcgggtgatg ctctatcagc ccagccagcg
     7621 cccgcgcctg cggtctggcg actggacaga aacatcattt gggcgatgcc gtattgaagg
     7681 acggctcggg caacgtcacg ccgatgttgt ggagtcgatt ctgtattgcg ccgagaagcg
     7741 ccgggatgtt tcggacggtg gaattgaact tctggttgac ccggctcgcg tccgaaaaac
     7801 gctgtcagac agccggtatt cacacgagcg gctatggtcg atattgcgcg agtgcatggg
     7861 cgcagtcatc gaagtcgaga cgcccacttt ccgcgtgctt ggacatttga ttgatcaggt
     7921 ggtcgagtcc ccaatgacgc gccgcaaccc actaacgggg gatgatcgcc caatgtggcg
     7981 ggtgaggctc ggtatggcgc ttgtgatgct gctagagcgc gatctgagcc tgtactacga
     8041 cccagcaccg attgcccggc tacagtacgg catcagccaa gccgtggcta ggcacatctt
     8101 gagccacaaa atcgaaccgc tgggcggctg gtatatcgac acggccatca tggccgtagc
     8161 cgggaagtcc ggcagccaaa ccatgcgcga cggccgtcgg cgactgaaag aggacgccga
     8221 cgaactgaag gcgttggggc tgatcctcga cggcgatcgg atcaggaaaa aacgggccga
     8281 cgacgcctaa agcgtggcac
//
