LOCUS       NZ_CP148388            18207 bp    DNA     circular CON 05-APR-2024
DEFINITION  Escherichia coli strain Z1323HEC0011 plasmid pZ1323HEC0011-4,
            complete sequence.
ACCESSION   NZ_CP148388
VERSION     NZ_CP148388.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN40441589
            Assembly: GCF_037553955.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Escherichia.
REFERENCE   1  (bases 1 to 18207)
  AUTHORS   Chae,J.-C., Oh,J.Y., Jeong,J.H. and Kwak,S.M.
  TITLE     Complete genome sequence of Escherichia coli isolated from humans,
            companion animals, industrial animals and wild animals
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 18207)
  AUTHORS   Chae,J.-C., Oh,J.Y., Jeong,J.H. and Kwak,S.M.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-MAR-2024) Division of biotechnology, Jeonbuk National
            University, kobongro, Iksan 54596, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. v0.4.9
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 124X
            Sequencing Technology :: Illumina NovaSeq; Oxford Nanopore MinION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_037553955.1-RS_2024_04_05
            Annotation Date                   :: 04/05/2024 20:13:52
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,747
            CDSs (total)                      :: 4,628
            Genes (coding)                    :: 4,409
            CDSs (with protein)               :: 4,409
            Genes (RNA)                       :: 119
            rRNAs                             :: 8, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 86
            ncRNAs                            :: 11
            Pseudo Genes (total)              :: 219
            CDSs (without protein)            :: 219
            Pseudo Genes (ambiguous residues) :: 0 of 219
            Pseudo Genes (frameshifted)       :: 64 of 219
            Pseudo Genes (incomplete)         :: 157 of 219
            Pseudo Genes (internal stop)      :: 39 of 219
            Pseudo Genes (multiple problems)  :: 38 of 219
            Pseudo Genes (short protein)      :: 4 of 219
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP148388.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..18207
                     /organism="Escherichia coli"
                     /mol_type="genomic DNA"
                     /strain="Z1323HEC0011"
                     /host="Homo sapiens"
                     /db_xref="taxon:562"
                     /plasmid="pZ1323HEC0011-4"
                     /geo_loc_name="South Korea"
                     /collection_date="2023-04-12"
     gene            complement(185..829)
                     /locus_tag="WHU55_RS23565"
                     /old_locus_tag="WHU55_23565"
     CDS             complement(185..829)
                     /locus_tag="WHU55_RS23565"
                     /old_locus_tag="WHU55_23565"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017900990.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="quinolone resistance pentapeptide repeat protein
                     QnrB4"
                     /protein_id="WP_017900990.1"
                     /translation="MTLALVGEKIDRNRFTGEKVENSTFFNCDFSGADLSGTEFIGCQF
                     YDRESQKGCNFSRANLKDAIFKSCDLSMADFRNINALGIEIRHCRAQGSDFRGASFMNM
                     ITTRTWFCSAYITNTNLSYANFSKVVLEKCELWENRWMGTQVLGATFSGSDLSGGEFSS
                     FDWRAANVTHCDLTNSELGDLDIRGVDLQGVKLDSYQASLLLERLGIAVMG"
                     /name="quinolone resistance pentapeptide repeat protein
                     QnrB4"
     gene            complement(912..1886)
                     /gene="pspF"
                     /locus_tag="WHU55_RS23570"
                     /old_locus_tag="WHU55_23570"
     CDS             complement(912..1886)
                     /gene="pspF"
                     /locus_tag="WHU55_RS23570"
                     /old_locus_tag="WHU55_23570"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_309907.2"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage shock protein operon transcriptional
                     activator"
                     /protein_id="WP_004193248.1"
                     /translation="MAGYKDNLLGEANSFIEVLEQVSRLAPLDKPVLVIGERGTGKELI
                     ANRLHYLSTRWQGPFISLNCAALNENLLDSELFGHEAGAFTGAQKRHPGRFERADGGTL
                     FLDELATAPMLVQEKLLRVIEYGELERVGGSQPLQVNVRLVCATNADLPRMVSEGTFRA
                     DLLDRLAFDVVQLPPLRERQSDIMLMAEHFAIQMCREIGLPLFPGFTDEAKETLLHYRW
                     PGNIRELKNVVERSVYRHGTSDYPLNEIVIDPFRRHAAPPLAQETRHTSVTLPLDLREF
                     QQQQEKEFLQTSLQQAKFNQKKAAELLGLTYHQLRALLKKHQI"
                     /name="pspF"
     gene            2057..2725
                     /gene="pspA"
                     /locus_tag="WHU55_RS23575"
                     /old_locus_tag="WHU55_23575"
     CDS             2057..2725
                     /gene="pspA"
                     /locus_tag="WHU55_RS23575"
                     /old_locus_tag="WHU55_23575"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_460648.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage shock protein PspA"
                     /protein_id="WP_003020532.1"
                     /translation="MGIFSRFADIVNANINALLEKAEDPQKLVRLMIQEMEDTLVEVRS
                     NSARALAEKKQLSRRIEQASAQQAEWQEKAELALRKEKEDLARSALIEKQKLTDLIASL
                     EHEVTLVDDTLARMKKEIGELENKLSETRARQQALMLRHQAASSSRDVRRQLDSGKLDE
                     AMARFESFERRIDQMEAEAESHNFGKQKSLDQQFADLKADDEISEQLAQLKAKMQQDKQ
                     "
                     /name="pspA"
     gene            2780..3004
                     /gene="pspB"
                     /locus_tag="WHU55_RS23580"
                     /old_locus_tag="WHU55_23580"
     CDS             2780..3004
                     /gene="pspB"
                     /locus_tag="WHU55_RS23580"
                     /old_locus_tag="WHU55_23580"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_460647.1"
                     /GO_process="GO:0009271 - phage shock [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="envelope stress response membrane protein PspB"
                     /protein_id="WP_004193245.1"
                     /translation="MSALFLAIPLTIFVLFVLPIWLWLHYSNRSSRGELAQSEQQRLVE
                     LNQDAQRMRERIQALEDILDAEHPNWRDR"
                     /name="pspB"
     gene            3004..3363
                     /gene="pspC"
                     /locus_tag="WHU55_RS23585"
                     /old_locus_tag="WHU55_23585"
     CDS             3004..3363
                     /gene="pspC"
                     /locus_tag="WHU55_RS23585"
                     /old_locus_tag="WHU55_23585"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_460646.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="envelope stress response membrane protein PspC"
                     /protein_id="WP_004193243.1"
                     /translation="MGGVNLNKKLWRIPQQGMVKGVCAGIAHYLDVPVKLVRILVVLSI
                     FFGLAFFTFVAYIVLTFVLDPMPDNVVSGEQQPSSGELLDAVDRELAASEKRLREMERY
                     VTSDTFTLRSRFRQL"
                     /name="pspC"
     gene            3372..3602
                     /gene="pspD"
                     /locus_tag="WHU55_RS23590"
                     /old_locus_tag="WHU55_23590"
     CDS             3372..3602
                     /gene="pspD"
                     /locus_tag="WHU55_RS23590"
                     /old_locus_tag="WHU55_23590"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003833267.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage shock protein PspD"
                     /protein_id="WP_004193241.1"
                     /translation="MNNRWQRAGQRVKPGIKIAGKLVLLTALRYGPAGVAGWAVKSVAR
                     RPLKMLLALVLEPLLSRAATKLSKRYSGNQP"
                     /name="pspD"
     gene            complement(3791..>3979)
                     /locus_tag="WHU55_RS23595"
                     /old_locus_tag="WHU55_23595"
                     /pseudo=""
     CDS             complement(3791..>3979)
                     /locus_tag="WHU55_RS23595"
                     /old_locus_tag="WHU55_23595"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000075350.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family transcriptional regulator"
                     /name="LacI family transcriptional regulator"
     gene            complement(3937..4758)
                     /locus_tag="WHU55_RS23600"
                     /old_locus_tag="WHU55_23600"
     CDS             complement(3937..4758)
                     /locus_tag="WHU55_RS23600"
                     /old_locus_tag="WHU55_23600"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_013214003.1"
                     /translation="MDVLRFILRLPFILLRLAARSLVYLFTLLGFLLRPFTGRIRWAVP
                     GWVTFAGNQLARLERGGNRYPKTISALLLLTAAVAAGSYYTWHWYQNKPKPVDVAPLVV
                     QDISASVQRPSAVNYNRDDNSAQIVVVTFSRSAAPVTLIGKPVTAGITLTPAMEGEWQW
                     RNDRKLVFTAKKTFPMGKTYTVDMDAKTLLAPQVALTEKQKTFTTPEFYYRGGRAEFYQ
                     DPQDPMKKHAIIGLTFNAPADVKNLESRLSMTRDGKPVPYTVTVMNCCHLC"
                     /name="hypothetical protein"
     gene            complement(4953..6092)
                     /locus_tag="WHU55_RS23605"
                     /old_locus_tag="WHU55_23605"
     CDS             complement(4953..6092)
                     /locus_tag="WHU55_RS23605"
                     /old_locus_tag="WHU55_23605"
                     /EC_number="3.5.2.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032097955.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="extended-spectrum class C beta-lactamase DHA-1"
                     /protein_id="WP_004236386.1"
                     /translation="MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIP
                     GMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMAL
                     NDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKP
                     GDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY
                     KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKT
                     AAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGF
                     GAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE"
                     /name="extended-spectrum class C beta-lactamase DHA-1"
     gene            6203..7078
                     /gene="ampR"
                     /locus_tag="WHU55_RS23610"
                     /old_locus_tag="WHU55_23610"
     CDS             6203..7078
                     /gene="ampR"
                     /locus_tag="WHU55_RS23610"
                     /old_locus_tag="WHU55_23610"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004236384.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator AmpR"
                     /protein_id="WP_004193231.1"
                     /translation="MVRRYLPLNPLRAFEAAARHLSFTRAAIELNVTHAAVSQQVRALE
                     EQLGCVLFTRVSRGLVLTHEGEGLLPVLNEAFDRIADTLECFSHGQFRERVKVGAVGTF
                     AAGWLLPRLAGFYDSHPHIDLHISTHNNHVDPAAEGHDYTIRFGNGAWHESDAELIFSA
                     PHAPLCSPAIAEQLQQPDDVHRFTLLRSFRRDEWSRWLDCAGGTPPSPSQPVMVFDTSL
                     AMAEAAQLGAGVAIAPVCMFSRLLQSGALVQPFAAEITLGGYWLTRLQSRTETPAMQQF
                     ARWLLNTAAA"
                     /name="ampR"
     gene            complement(7082..7447)
                     /gene="hypA"
                     /locus_tag="WHU55_RS23615"
                     /old_locus_tag="WHU55_23615"
     CDS             complement(7082..7447)
                     /gene="hypA"
                     /locus_tag="WHU55_RS23615"
                     /old_locus_tag="WHU55_23615"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004193196.1"
                     /GO_function="GO:0008901 - ferredoxin hydrogenase activity
                     [Evidence IEA]"
                     /GO_process="GO:0036211 - protein modification process
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydrogenase maturation nickel metallochaperone
                     HypA"
                     /protein_id="WP_025999322.1"
                     /translation="MTDYDNGGRGKLSKALGAADIIREQAEQHGIARVTDVWLEVGALA
                     DVEESALHFCFDIACRDTVAQGCTLHIDVIPAQAWCWDCSREAEIMQHAGCCPHCGSER
                     LRISEGDDLRVKSLEGE"
                     /name="hypA"
     gene            7340..7675
                     /locus_tag="WHU55_RS23620"
                     /old_locus_tag="WHU55_23620"
     CDS             7340..7675
                     /locus_tag="WHU55_RS23620"
                     /old_locus_tag="WHU55_23620"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000679428.1"
                     /GO_component="GO:0016020 - membrane [Evidence IEA];
                     GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SMR family transporter"
                     /protein_id="WP_052238321.1"
                     /translation="MRYPRNAVLFSLFADNVRRTEGFTKLAPSAVVIIGYGIAFYFLSL
                     VLKSIPVGVAYAVWSGLGVVIITAIAWLLHGQKLDAWGFVGMGLIIAAFLLARSPSWKS
                     LRRPTPW"
                     /name="SMR family transporter"
     gene            7669..8508
                     /gene="sul1"
                     /locus_tag="WHU55_RS23625"
                     /old_locus_tag="WHU55_23625"
     ARG             7670..8505
                     /name="sul1"
                     /gene="sul1"
                     /gene_name="sulfonamide-resistant dihydropteroate synthase
                     Sul1"
                     /tool="amrfinderplus"
                     /drug_class="SULFONAMIDE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            8636..8839
                     /locus_tag="WHU55_RS23630"
                     /old_locus_tag="WHU55_23630"
     CDS             8636..8839
                     /locus_tag="WHU55_RS23630"
                     /old_locus_tag="WHU55_23630"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000376616.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000376616.1"
                     /translation="MDSEEPPNVRVACSGDIDEVVRLMHDAAAWMSAKGTPAWDVARID
                     RTFAETFVLRSELLGIASENGK"
                     /name="hypothetical protein"
     gene            8995..10200
                     /gene="chrA"
                     /locus_tag="WHU55_RS23635"
                     /old_locus_tag="WHU55_23635"
     CDS             8995..10200
                     /gene="chrA"
                     /locus_tag="WHU55_RS23635"
                     /old_locus_tag="WHU55_23635"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004896675.1"
                     /GO_function="GO:0015109 - chromate transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0015703 - chromate transport [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chromate efflux transporter"
                     /protein_id="WP_000184001.1"
                     /translation="MTNNPTDDSRPWSVFLIFLRLGLTSFGGPIAHLGYFRAEFVTRRR
                     WLSERSYADLVALCQFLPGPASSQVGIAVGLSRAGYSGALAAWAGFTLPSAIALILFAL
                     GISSYGDYVSQGALHGLKVVAVAVVAQAVWGMARNLCTDGLRVTIMAIATCVVLLVPSA
                     WGQVGVIAIAGIAGRLLFKPAKVVEHDPLPITVSHRAGVLWLSLFFVLLIGLPVLAELM
                     PSQTMAMVDSFYRVGSLVFGGGHVVLPLLQAEVVPSGWVNNESFLAGYGAAQAVPGPLF
                     TFAAFLGASMNTAPSGWIGGIVCLLAIFAPSFLLVVGSMPFWERLRRNTGIQAALAGIN
                     AAVVGLLLAALYQPVWTSAIFQPQDFGLALVALVALMFWKLPPWLVVLGSGAAGWLLSV
                     AL"
                     /name="chrA"
     gene            10211..10516
                     /locus_tag="WHU55_RS23640"
                     /old_locus_tag="WHU55_23640"
     CDS             10211..10516
                     /locus_tag="WHU55_RS23640"
                     /old_locus_tag="WHU55_23640"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000130000.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PadR family transcriptional regulator"
                     /protein_id="WP_000130000.1"
                     /translation="MTDKDLYGGLIRLHILHHAAEEPVFGLGIIEELRRHGYEMSAGTV
                     YPMLHGLEKKGYLTSRHERTGRRERRVYDITEQGRTALADAKTKVKELFGELVEGG"
                     /name="PadR family transcriptional regulator"
     gene            <10560..10625
                     /locus_tag="WHU55_RS23645"
                     /old_locus_tag="WHU55_23645"
                     /pseudo=""
     CDS             <10560..10625
                     /locus_tag="WHU55_RS23645"
                     /old_locus_tag="WHU55_23645"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_005229646.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="EAL domain-containing protein"
                     /name="EAL domain-containing protein"
     gene            10743..11507
                     /locus_tag="WHU55_RS23650"
                     /old_locus_tag="WHU55_23650"
     CDS             10743..11507
                     /locus_tag="WHU55_RS23650"
                     /old_locus_tag="WHU55_23650"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001389365.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS6100 family transposase"
                     /protein_id="WP_001389365.1"
                     /translation="MTDFKWRHFQGDVILWAVRWYCRYPISYRDLEEMLAERGISVDHT
                     TIYRWVQCYAPEMEKRLRWFWRRGFDPSWRLDETYVKVRGKWTYLYRAVDKRGDTIDFY
                     LSPTRSAKAAKRFLGKALRGLKHWEKPATLNTDKAPSYGAAITELKREGKLDRETAHRQ
                     VKYLNNVIEADHGKLKILIKPVRGFKSIPTAYATIKGFEVMRALRKGQARPWCLQPGIR
                     GEVRLVERAFGIGPSALTEAMGMLNHHFAAAA"
                     /name="IS6-like element IS6100 family transposase"
     gene            complement(12000..12584)
                     /gene="mphR(A)"
                     /locus_tag="WHU55_RS23655"
                     /old_locus_tag="WHU55_23655"
     CDS             complement(12000..12584)
                     /gene="mphR(A)"
                     /locus_tag="WHU55_RS23655"
                     /old_locus_tag="WHU55_23655"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001137892.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="macrolide-binding transcriptional repressor
                     MphR(A)"
                     /protein_id="WP_001137892.1"
                     /translation="MPRPKLKSDDEVLEAATVVLKRCGPIEFTLSGVAKEVGLSRAALI
                     QRFTNRDTLLVRMMERGVEQVRHYLNAIPIGAGPQGLWEFLQVLVRSMNTRNDFSVNYL
                     ISWYELQVPELRTLAIQRNRAVVEGIRKRLPPGAPAAAELLLHSVIAGATMQWAVDPDG
                     ELADHVLAQIAAILCLMFPEHDDFQLLQAHA"
                     /name="mphR(A)"
     gene            complement(12584..13822)
                     /gene="mrx(A)"
                     /locus_tag="WHU55_RS23660"
                     /old_locus_tag="WHU55_23660"
                     /gene_synonym="mrx"
     CDS             complement(12584..13822)
                     /gene="mrx(A)"
                     /locus_tag="WHU55_RS23660"
                     /old_locus_tag="WHU55_23660"
                     /gene_synonym="mrx"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000004159.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="macrolide resistance MFS transporter Mrx(A)"
                     /protein_id="WP_000004159.1"
                     /translation="MSERRYSPLATLFAATFLFRIGNAVAALALPWFVLSHTKSAAWAG
                     ATAASSVIATIIGAWVGGGLVDRFGRAPVALISGVVGGVAMASIPLLDAVGALSNTGLI
                     ACVVLGAAFDAPGMAAQDSELPKLGHVAGLSVERVSSLKAVIGNVAILGGPALGGAAIG
                     LLGAAPTLGLTAFCSVLAGLLGAWVLPARAARTMTTTATLSMRAGVAFLWSEPLLRPLF
                     GIVMIFVGIVGANGSVIMPALFVDAGRQVAELGLFSSMMGAGGLLGIAIHASVGARISA
                     QNWLAVAFCGSAVGSLLLSQLPGVPVLMLLGALVGLLTGSVSPILNAAIYNRTPPELLG
                     RVLGTVSAVMLSASPMVMLAAGAFVDLAGPLPGLVVSAVFAGLVALLSLRLQFATMAAA
                     ATASAPTHTEGEH"
                     /name="mrx(A)"
     gene            complement(13819..14724)
                     /locus_tag="WHU55_RS23665"
                     /old_locus_tag="WHU55_23665"
     CDS             complement(13819..14724)
                     /locus_tag="WHU55_RS23665"
                     /old_locus_tag="WHU55_23665"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000219391.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Mph(A) family macrolide 2'-phosphotransferase"
                     /protein_id="WP_000219391.1"
                     /translation="MTVVTTADTSQLYALAARHGLKLHGPLTVNELGLDYRIVIATVDD
                     GRRWVLRIPRRAEVSAKVEPEARVLAMLKNRLPFAVPDWRVANAELVAYPMLEDSTAMV
                     IQPGSSTPDWVVPQDSEVFAESFATALAALHAVPISAAVDAGMLIRTPTQARQKVADDV
                     DRVRREFVVNDKRLHRWQRWLDDDSSWPDFSVVVHGDLYVGHVLIDNTERVSGMIDWSE
                     ARVDDPAIDMAAHLMVFGEEGLAKLLLTYEAAGGRVWPRLAHHIAERLAFGAVTYALFA
                     LDSGNEEYLAAAKAQLAAAE"
                     /name="Mph(A) family macrolide 2'-phosphotransferase"
     gene            complement(14846..15550)
                     /locus_tag="WHU55_RS23670"
                     /old_locus_tag="WHU55_23670"
     CDS             complement(14846..15550)
                     /locus_tag="WHU55_RS23670"
                     /old_locus_tag="WHU55_23670"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_005221000.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS26 family transposase"
                     /protein_id="WP_001067855.1"
                     /translation="MNPFKGRHFQRDIILWAVRWYCKYGISYRELQEMLAERGVNVDHS
                     TIYRWVQRYAPEMEKRLRWYWRNPSDLCPWHMDETYVKVNGRWAYLYRAVDSRGRTVDF
                     YLSSRRNSKAAYRFLGKILNNVKKWQIPRFINTDKAPAYGRALALLKREGRCPSDVEHR
                     QIKYRNNVIECDHGKLKRIIGATLGFKSMKTAYATIKGIEVMRALRKGQASAFYYGDPL
                     GEMRLVSRVFEM"
                     /name="IS6-like element IS26 family transposase"
     gene            complement(<15618..15944)
                     /locus_tag="WHU55_RS23675"
                     /old_locus_tag="WHU55_23675"
                     /pseudo=""
     CDS             complement(<15618..15944)
                     /locus_tag="WHU55_RS23675"
                     /old_locus_tag="WHU55_23675"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000503573.1"
                     /GO_function="GO:0016779 - nucleotidyltransferase activity
                     [Evidence IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotidyltransferase domain-containing protein"
                     /name="nucleotidyltransferase domain-containing protein"
     ARG             complement(16076..16674)
                     /name="dfrA17"
                     /gene="dfrA17"
                     /gene_name="trimethoprim resistant dihydrofolate reductase
                     dfr"
                     /tool="rgi"
                     /drug_class="diaminopyrimidine antibiotic"
                     /identity="99.36"
                     /coverage="126.75"
     ARG             complement(16079..16548)
                     /name="dfrA17"
                     /gene="dfrA17"
                     /gene_name="trimethoprim-resistant dihydrofolate reductase
                     DfrA17"
                     /tool="amrfinderplus"
                     /drug_class="TRIMETHOPRIM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            16706..>17386
                     /gene="intI1"
                     /locus_tag="WHU55_RS23685"
                     /old_locus_tag="WHU55_23685"
                     /pseudo=""
     CDS             16706..>17386
                     /gene="intI1"
                     /locus_tag="WHU55_RS23685"
                     /old_locus_tag="WHU55_23685"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_005221021.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="class 1 integron integrase IntI1"
                     /name="intI1"
     gene            17451..18155
                     /locus_tag="WHU55_RS23690"
                     /old_locus_tag="WHU55_23690"
     CDS             17451..18155
                     /locus_tag="WHU55_RS23690"
                     /old_locus_tag="WHU55_23690"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_005221000.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS26 family transposase"
                     /protein_id="WP_001067855.1"
                     /translation="MNPFKGRHFQRDIILWAVRWYCKYGISYRELQEMLAERGVNVDHS
                     TIYRWVQRYAPEMEKRLRWYWRNPSDLCPWHMDETYVKVNGRWAYLYRAVDSRGRTVDF
                     YLSSRRNSKAAYRFLGKILNNVKKWQIPRFINTDKAPAYGRALALLKREGRCPSDVEHR
                     QIKYRNNVIECDHGKLKRIIGATLGFKSMKTAYATIKGIEVMRALRKGQASAFYYGDPL
                     GEMRLVSRVFEM"
                     /name="IS6-like element IS26 family transposase"
     ARG             complement(189..829)
                     /name="qnrB4"
                     /gene="qnrB4"
                     /gene_name="quinolone resistance pentapeptide repeat
                     protein QnrB4"
                     /tool="amrfinderplus"
                     /drug_class="QUINOLONE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             complement(13823..14724)
                     /name="mph(A)"
                     /gene="mph(A)"
                     /gene_name="Mph(A) family macrolide 2'-phosphotransferase"
                     /tool="amrfinderplus"
                     /drug_class="MACROLIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             complement(4957..6092)
                     /name="blaDHA-1"
                     /gene="blaDHA-1"
                     /gene_name="extended-spectrum class C beta-lactamase DHA-1"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             complement(13820..14724)
                     /name="mphA"
                     /gene="mphA"
                     /gene_name="macrolide phosphotransferase (MPH)"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             complement(15598..15944)
                     /name="aadA5"
                     /gene="aadA5"
                     /gene_name="ANT(3'')"
                     /tool="rgi"
                     /drug_class="aminoglycoside antibiotic"
                     /identity="100.0"
                     /coverage="43.89"
     ARG             complement(12585..13822)
                     /name="Mrx"
                     /gene="Mrx"
                     /gene_name="macrolide phosphotransferase (MPH)"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic"
                     /identity="100.0"
                     /coverage="100.0"
ORIGIN
        1 ctccgctgta tgtcacttta gcggctgaag agaacagcta tacatccggt caggtatggt
       61 gttctgacgg ggggaccgga accctctgac gtttatgccc ccgaagtcga aacgtctgag
      121 ggggaaagcc agcccggaca atattgtata agggcagggg gcggcatata ccgctccctg
      181 aacattaacc catgacagcg ataccaagac gttccaggag caacgatgcc tggtagctgt
      241 ccagtttgac gccttgcaaa tcaaccccgc ggatatctaa atcgcccagt tccgaattgg
      301 tcaaatcaca gtgcgtaacg tttgctgctc gccagtcgaa ggatgaaaac tcgccgccag
      361 agaggtctga tccactgaac gttgcgccca gcacctgagt acccatccag cggttttccc
      421 acagctcgca cttttccagt acgacttttg aaaagttggc gtagcttaag ttggtattgg
      481 tgatataggc gctacaaaac caggtgcggg tggtgatcat attcataaaa cttgcgccgc
      541 gaaaatctga cccttgtgcc cggcagtggc gaatttcgat tcccagcgca ttgatattcc
      601 tgaaatcagc catggagaga tcacaacttt tgaaaatggc atctttcagg ttagcgcgac
      661 taaaattaca tcctttctga ctttctcgat cataaaactg gcagccaata aattcagtgc
      721 cgctaaggtc ggcacccgaa aaatcacagt tgaaaaatgt gctattttca actttttcac
      781 cggtgaacct gtttctgtca attttttcgc caactaacgc cagagtcatc atgattaacc
      841 tgttttttta tacagtgatt gcaacatggt aaactgtttt aactctcgcg tccaacgtct
      901 gcccctgcac gctaaatttg gtgtttcttc agtaatgcgc ggagttgatg gtaggtcaga
      961 cctaataatt cagcggcttt tttctgatta aatttcgcct gctgtaagct ggtttgcaaa
     1021 aattccttct cctgctgctg ttggaattca cgcagatcca gcggtagggt tactgatgta
     1081 tgtctggttt cttgcgccag cggcggtgcg gcgtgacgcc tgaacgggtc aatcacaatc
     1141 tcattcagtg ggtaatcgct ggtcccgtgt cggtataccg aacgctccac gacgtttttc
     1201 agttcacgaa tattgcccgg ccaacggtag tggaggagcg tttctttggc ctcatcggtg
     1261 aacccaggaa acaacggtaa cccgatctca cggcacatct gaatggcaaa atgttcagcc
     1321 attaacatga tatcgctttg acgttcgcgt aacgggggaa gttgcaccac gtcaaaggcc
     1381 agacgatcca gcaggtcggc gcggaacgtg ccttcactca ccatgcgtgg caggtcggcg
     1441 ttggttgcgc aaaccagtct tacattgacc tgcagaggtt ggctaccgcc tacgcgttcc
     1501 agctctccgt actcaataac gcgcagcagt ttttcctgta ccagcatcgg ggcggttgcc
     1561 agttcatcaa gaaacagtgt gccgccatcg gcgcgctcga accgacctgg gtgacgtttc
     1621 tgcgcgccgg taaaggcgcc cgcttcgtgc ccaaagagtt cggaatcaag taaattttcg
     1681 ttgagcgcgg cgcagttaag tgaaataaac gggccttgcc aacgggttga gaggtagtgc
     1741 aggcggttgg cgataagctc tttccctgtt cctcgttccc caatgaccag cacaggttta
     1801 tccagcggcg cgagacgaga aacctgctcc agcacttcaa taaagctgtt cgcttcgccc
     1861 agcagattat ctttgtatcc tgccatgatg aaattcacca tttgttagtg ttattcacca
     1921 atttacccta tttatcccga caggtaaaat tagttatttt caaatatttc aatgaattaa
     1981 aaagttggca tgcgaagtgc attagaacag cagcagggca ttgcccgata tcagaacagt
     2041 aagtgaggat tacattatgg gtattttttc tcgttttgcc gacatcgtga acgccaacat
     2101 taatgcgttg ctggaaaagg ctgaagatcc gcagaagctg gtgcggttga tgatccagga
     2161 aatggaagac acgctggttg aggtgcgctc caactccgca cgcgcgctgg cagaaaagaa
     2221 acagttatcg cgtcgtattg aacaggccag cgcccaacag gcagagtggc aggaaaaagc
     2281 agagctggcg ctgcgtaaag aaaaagaaga tttggcgcgt tctgcgttaa tcgaaaagca
     2341 gaaactgact gacctgattg cctccctgga gcatgaggtg acgctggttg acgatacgct
     2401 ggcgcgtatg aaaaaagaga tcggtgaact ggaaaacaaa ctcagtgaaa cccgtgctcg
     2461 tcagcaggca ttgatgttgc gccatcaggc ggcgagttct tcccgtgatg ttcgtcgtca
     2521 actggacagc ggcaaactgg atgaagcgat ggctcgcttt gaatcttttg agcgtcgtat
     2581 cgatcaaatg gaagctgaag ctgaaagcca taacttcggt aagcagaagt ctttggatca
     2641 gcaatttgct gacctgaaag cagatgatga aatcagcgag cagttggcgc aattgaaagc
     2701 caaaatgcag caagacaagc aataataata tctggcggtg cccgaacgcg ccgccgctca
     2761 tcacctgtaa ggagtactca tgagcgcgct atttctggcc atcccgttaa ccatctttgt
     2821 gctgttcgtc ttaccgattt ggctctggct gcattacagc aatcgttcca gtcgcggcga
     2881 gctggcgcaa agtgaacaac agcgtctggt agaacttaac caggacgcac agcggatgcg
     2941 tgagcgcatt caagcgctgg aagacatcct tgatgctgaa catccaaact ggagggaccg
     3001 ctaatggggg gcgttaatct gaataaaaaa ctgtggcgta taccgcagca gggcatggtg
     3061 aaaggggttt gcgcgggtat tgcgcattat ctcgatgttc ctgtgaaact ggtgcggatc
     3121 ctggtggtgc tgtccatctt ttttggtctg gcctttttca cctttgtcgc ctacatcgta
     3181 ctgacgtttg tgttggatcc gatgccagac aacgtggttt ccggagaaca gcagccatca
     3241 agcggtgagc tattggatgc tgtcgatcgt gaactggctg caagtgaaaa gcgtttgcgt
     3301 gagatggagc gttatgtaac gtctgatact tttacattac gcagccgctt ccgccaattg
     3361 tgaggttaga aatgaataat cgctggcaac gtgccgggca aagggttaag ccgggcatta
     3421 aaatagcagg taagctggtg ctactgactg cgctgcgcta tggcccggct ggggtagcag
     3481 ggtgggcggt gaagtccgtg gcccgacgtc cgctaaaaat gttgctggcg ttagtattgg
     3541 aacctttgtt gagccgggca gcgacaaaat tgtcgaaacg ctattcaggt aatcaaccct
     3601 gatatccgaa acaacaaaag caagcaacat ttagtcaaca ttcccccagt taatttgcgg
     3661 cagagtagtc tcttgtgtca tgggatcgct accaatagaa atgaaggtga aagcgacaga
     3721 ctccattatg caggtatcgg tgtgaattac gcattctaaa atgcactggg gcattgttat
     3781 gccccagttt ttataccagt gagtcggcta acgatatttg tgtacccacg gtgatatttt
     3841 gtaaaccttt ctcaccggca atcaggctaa ataataaatt acagctttgt tcgccgagct
     3901 gctgggttgg gacatcaatg cctcccggca cgggcgtcag cataaatgac aacagttcat
     3961 tacagtgacg gtatacggca ccggcttgcc gtcacgggtc atagacagac gcgattccag
     4021 atttttgaca tcagcggggg cattgaaggt caggccgata atggcgtgtt ttttcatcgg
     4081 atcttgcgga tcctgataga actccgcccg gccgccgcga taataaaact caggggtggt
     4141 aaaggttttt tgtttctctg ttaacgccac ctgcggagcc agcagtgttt tggcatccat
     4201 atcgacggtg taggttttcc ccatcgggaa ggtttttttc gccgtgaata ccagcttacg
     4261 gtcattacgc cactgccact caccttccat tgcgggggtc agggtaatac cggcggtgac
     4321 cggtttaccg atcagcgtta ccggtgcggc agagcgggag aatgtcacca ccacaatctg
     4381 cgctgaatta tcatcacggt tataattaac cgccgaaggg cgctgcacag acgcggaaat
     4441 atcctgcacc accagcggcg caacatccac cggcttcggt ttgttctgat accagtgcca
     4501 ggtgtaataa ctgcccgctg ccaccgcagc agtcagtaat aataaggcag atatggtttt
     4561 cggatagcgg ttgccccccc gctccagccg ggcaagctga ttaccggcaa aggtcaccca
     4621 gcccggcacc gcccagcgga tccgtccggt gaacgggcgc agcagaaaac ccagcagagt
     4681 aaagagataa acaagactgc gagccgccag acgcagcaaa ataaaaggta agcggaggat
     4741 aaaacgcaga acgtccatga caacattttc ctctgtgtgt tgagactgac atcagtttgc
     4801 cgcagcacac agtgaaatcc ggttcagccg gaagctgtca gtgcccgata ctctcatcct
     4861 ccataaaaca gcccataaag caaattattg cataaggaat aatcttaaat tacggccccg
     4921 gcgtatccgc aggggcctgt tcaggaaaaa aattattcca gtgcactcaa aatagcctgt
     4981 gcagctttga ctctttcggt attcgggtag tttttattcg ccagaatcac aatcgccacc
     5041 tgtttttccg gaataaaggc gacataggcg ccgaaaccag ttgttgcgcc cgttttatgc
     5101 acccaggaag cacggttata cggctgaacc tggttgtctg ttaccggatg cggctgcaat
     5161 gcgacctcgt tggtcacacc gttaatgatc atatctttct gctgcggcca gtcatacatt
     5221 tcccagccca gcccctggtt aatcgcggcg gttttatagt agcgggtctg ggcgagatac
     5281 attgccattt ccagatccgc attaccggcc cgtgacggct ccatattcat ttccgcccag
     5341 cgcagcatat cttttgaggc ggatttcacg ccgtaagatt ccgcatcaag ctgtcccggc
     5401 gacacgcgga ccggtttttt gtttttataa ccgtacgcat actggctttg cgcactttcc
     5461 ggcacagtaa taaaggtgtg agataacccc agcggtgcca ggatccgtgc agtcagcaac
     5521 tgctcatacg gcatccccgc cgcgtttgcg gtcagagcac caaacaggcc gatactgctg
     5581 tttgcataca gacgcatatc gcccggtttc cgggacggct gccactgctg atagaaattc
     5641 agcagatccg cacggctttt taccgcatcc ggcacctgta acggcagtcc gcctgcggta
     5701 taggtagcca gatccagcaa tgtgatcccc ttccactgcg gcagagccag ctccggctgg
     5761 tattttgccg ccggatcatt cagcgccatc tcttttttcg ccacagaaac cgcacccagc
     5821 acacctgtga aagttttact tacagatccg agctcaaata gtgtattttc agtgaccggc
     5881 tgttttgcct gaatatcggc aaaaccataa ttgaaataat agggcttacc ctttacggag
     5941 acggcaaccg ccatcccggg aatatcctgc tgtgccatca gcggtttaat ggtgctgtcc
     6001 accaccgccg cgacattatc agcggcagaa aaccccgggg cggaaaacgc cagcagagcg
     6061 gaaatcagtg ttgcagataa cgattttttc atcagaatta accttccgtg tgtgagtaac
     6121 ggcggcaatt atcgtcagat tcaccggaca gaacaaacgg ttatttataa caagagccta
     6181 aagaaaaact tacaggtgga ttatggtcag acgttatctc ccccttaacc cgctgcgcgc
     6241 ctttgaggcc gccgcccgtc atctcagttt tacccgcgcg gcgattgagc tgaatgtcac
     6301 ccatgccgcc gtcagccagc aggtcagggc gctggaagaa caactcggct gtgtgctgtt
     6361 tacccgcgtc tcgcgcgggc tggtgctgac ccatgaaggt gagggattac tgccggtgct
     6421 caatgaggcg tttgaccgga ttgcggatac tctggagtgt ttttctcacg ggcagttccg
     6481 tgagcgggtg aaagtcggtg cggtgggaac atttgccgca ggctggctgc tgccgcgtct
     6541 ggccggattc tatgacagcc atccgcatat tgatctgcat atctccaccc ataacaatca
     6601 tgtggacccg gcggcggaag ggcatgatta tacgatccgt ttcggtaacg gcgcgtggca
     6661 tgagtcagat gcggaactga ttttcagtgc accacacgct ccgctgtgct caccggccat
     6721 tgcagaacag ttacagcagc cggatgatgt tcaccgcttt accctgctgc gctcattccg
     6781 ccgggatgaa tggagccgct ggctggattg tgcgggcggc acaccgcctt ccccgtcaca
     6841 gccggtaatg gtgttcgata cctcactggc catggccgag gcggcacaac tgggtgccgg
     6901 ggtagcgatc gcaccggtat gtatgttcag ccgcctgtta cagtcaggcg cactggtaca
     6961 gccgtttgcc gcagaaatca ccctcggcgg ctactggctg acgcggttac agtcccgtac
     7021 ggaaaccccg gccatgcagc aattcgcccg ctggctgctg aatacggcgg cggcgtaaaa
     7081 ctcactcacc ttccaggctt tttacccgca aatcatcacc ttcactgatg cgcagccgtt
     7141 cactgccgca gtgcggacag catccggcgt gctgcatgat ttcggcctca cggctgcaat
     7201 cccagcacca tgcctgtgcc gggataacat caatatgcag tgtgcagccc tgcgccacgg
     7261 tatcacggca ggcgatatca aaacagaaat gcagtgcact ctcctcaaca tccgccagtg
     7321 cgccgacttc cagccagaca tccgttaccc gcgcaatgcc gtgctgttca gcctgttcgc
     7381 ggataatgtc cgccgcaccg agggctttac taagcttgcc ccttccgccg ttgtcataat
     7441 cggttatggc atcgcatttt attttctttc tctggttctg aaatccatcc ctgtcggtgt
     7501 tgcttatgca gtctggtcgg gactcggcgt cgtcataatt acagccattg cctggttgct
     7561 tcatgggcaa aagcttgatg cgtggggctt tgtaggtatg gggctcataa ttgctgcctt
     7621 tttgctcgcc cgatccccat cgtggaagtc gctgcggagg ccgacgccat ggtgacggtg
     7681 ttcggcattc tgaatctcac cgaggactcc ttcttcgatg agagccggcg gctagacccc
     7741 gccggcgctg tcaccgcggc gatcgaaatg ctgcgagtcg gatcagacgt cgtggatgtc
     7801 ggaccggccg ccagccatcc ggacgcgagg cctgtatcgc cggccgatga gatcagacgt
     7861 attgcgccgc tcttagacgc cctgtccgat cagatgcacc gtgtttcaat cgacagcttc
     7921 caaccggaaa cccagcgcta tgcgctcaag cgcggcgtgg gctacctgaa cgatatccaa
     7981 ggatttcctg accctgcgct ctatcccgat attgctgagg cggactgcag gctggtggtt
     8041 atgcactcag cgcagcggga tggcatcgcc acccgcaccg gtcaccttcg acccgaagac
     8101 gcgctcgacg agattgtgcg gttcttcgag gcgcgggttt ccgccttgcg acggagcggg
     8161 gtcgctgccg accggctcat cctcgatccg gggatgggat ttttcttgag ccccgcaccg
     8221 gaaacatcgc tgcacgtgct gtcgaacctt caaaagctga agtcggcgtt ggggcttccg
     8281 ctattggtct cggtgtcgcg gaaatccttc ttgggcgcca ccgttggcct tcctgtaaag
     8341 gatctgggtc cagcgagcct tgcggcggaa cttcacgcga tcggcaatgg cgctgactac
     8401 gtccgcaccc acgcgcctgg agatctgcga agcgcaatca ccttctcgga aaccctcgcg
     8461 aaatttcgca gtcgcgacgc cagagaccga gggttagatc atgcctagca ttcaccttcc
     8521 ggccgcccgc tagcggaccc tggtcaggtt ccgcgaaggt gggcgcagac atgctgggct
     8581 cgtcaggatc aaactgcact atgaggcggc ggttcatacc gcgccagggg agcgaatgga
     8641 cagcgaggag cctccgaacg ttcgggtcgc ctgctcgggt gatatcgacg aggttgtgcg
     8701 gctgatgcac gacgctgcgg cgtggatgtc cgccaaggga acgcccgcct gggacgtcgc
     8761 gcggatcgac cggacattcg cggagacctt cgtcctgaga tccgagctcc tagggatcgc
     8821 ctcagaaaac ggaaaataaa gcacgctaag ccgtaagtaa gcgtgctcct gtgaaagcca
     8881 cagctaaaac tgcgtagtac acatagaggt atttttttct agatttatat cgaatttcgt
     8941 tatcgaattt cgcttattat tgatcaactc gttgcagatc atgaaggcga aagtatgacg
     9001 aataacccta ccgatgacag cagaccatgg tcggtctttc ttatttttct gcggcttgga
     9061 ttgacatctt ttggcggccc cattgcgcac ttgggctact tccgcgccga atttgtcaca
     9121 cggcggcgct ggctctccga acggagctat gctgacttgg tcgcgctttg tcagttcttg
     9181 ccagggcctg caagcagcca ggtcggcata gcggtaggac tgtctcgggc tggatacagc
     9241 ggggcgctgg ctgcttgggc tggcttcacg ctgccgtctg ccatagcctt gatccttttt
     9301 gcgctcggca tctccagcta tggcgattac gtctcgcagg gcgcgttgca tggcttaaaa
     9361 gtggtggctg tggccgtggt cgctcaagca gtatggggca tggcgcgtaa cctatgcacg
     9421 gatgggctgc gagtcaccat catggcaatt gctacctgcg tcgttttact tgtgccgtcc
     9481 gcgtggggac aggttggcgt gattgctatc gcaggcatcg caggccggtt attgttcaag
     9541 ccagcgaaag ttgttgagca tgacccccta cctatcacgg tcagtcaccg ggccggcgtg
     9601 ctttggctct cgctgttctt tgtcttgctg attggcctgc cggtgttggc cgaactgatg
     9661 ccaagtcaaa ccatggcaat ggtggattcc ttctatcgtg tcggatcact ggtgttcggc
     9721 ggtggtcacg ttgtgctgcc attactgcaa gccgaagtgg tgccctccgg ctgggtcaac
     9781 aatgaatcct ttctcgcggg gtacggggca gctcaagcgg tgcccggccc tttgttcacg
     9841 ttcgccgcgt ttcttggtgc ctcgatgaac accgccccgt cgggctggat cggcggcatt
     9901 gtgtgtctgc tggctatctt cgcgccctcg ttcttgctgg tcgtcggatc aatgccattt
     9961 tgggagcgtt tgcgccgcaa tacaggcatc caagctgcgc tggccgggat caatgccgct
    10021 gtagtcggct tgctgctggc cgcgctgtat cagcctgtat ggactagcgc catctttcag
    10081 ccgcaagact tcggcttggc attagttgcc cttgtcgcac ttatgttctg gaagctcccg
    10141 ccgtggctgg ttgtcctcgg tagcggtgca gctgggtggc tgttgagcgt cgctctgtga
    10201 ggcacaaaaa atgactgaca aagacctcta cggcggtttg atccgcctgc acatccttca
    10261 ccatgcagcc gaggaacctg tctttgggct ggggatcatc gaagagctac gccgacacgg
    10321 ctacgagatg agcgctggca ccgtgtaccc gatgctgcac ggcctggaaa aaaaaggcta
    10381 tctgacctca cgccacgaac gcaccgggcg acgtgaacgg cgtgtttatg acatcactga
    10441 acaaggcaga actgcacttg ctgatgcgaa aacaaaggtc aaggagctgt tcggagagtt
    10501 ggtagaaggt ggttgagttt ttgcttctat gtcaggttga gctataccct aactggattg
    10561 tcattttcag aagacgactg caccagttga ttgggcgtaa tggctgttgt gcagccagct
    10621 cctgacagtt caatatcaga agtgatctgc accaatctcg actatgctca atactcgtgt
    10681 gggctctgtt gcaaaaatcg tgaagcttga gcatgcttgg cggagattgg acggacggaa
    10741 cgatgacgga tttcaagtgg cgccatttcc agggtgatgt gatcctgtgg gcggtgcgct
    10801 ggtattgtcg ctatccgatc agctatcgcg accttgagga aatgctggcg gaacgcggca
    10861 tttcggtcga ccatacgacg atctatcgct gggtccagtg ctacgccccg gagatggaga
    10921 agcggctgcg ctggttctgg cggcgtggct ttgatccgag ctggcgcctg gatgaaacct
    10981 acgtcaaggt gcggggcaag tggacctacc tgtaccgggc agtcgacaag cggggcgaca
    11041 cgatcgattt ctacctgtcg ccgacccgca gcgccaaggc agcgaagcgg ttcctgggca
    11101 aggccctgcg aggcctgaag cactgggaaa agcctgccac gctcaatacc gacaaagcgc
    11161 cgagctatgg tgcagcgatc accgaattga agcgcgaagg aaagctggac cgggagacgg
    11221 cccaccggca ggtgaagtat ctcaataacg tgatcgaggc cgatcacgga aagctcaaga
    11281 tactgatcaa gccggtgcgc ggtttcaaat cgatccccac ggcctatgcc acgatcaagg
    11341 gattcgaagt catgcgagcc ctgcgcaaag gacaggctcg cccctggtgc ctgcagcccg
    11401 gcatcagggg cgaggtgcgc cttgtggaga gagcttttgg cattgggccc tcggcgctga
    11461 cggaggccat gggcatgctc aaccaccatt tcgcagcagc cgcctgatcg gcgcagagcg
    11521 acagcctacc tctgactgcc gccaatcttt gcaacagagc ccgccgtgct agtctgctcg
    11581 gtgatggtgg agtgaagcca acccgcaatc gggttatgaa tctgcatcgc gattcgcaat
    11641 cagctgtctc ttgagcatgt cgaactcctg cgatgttatc tcgccgtgct cgtgctgcta
    11701 caccaacttg tccaactcat ccgccacacc gctccccacc acctgcgatg gccaggttgt
    11761 ttgctgggcg cattggcgga gtatcgtctc gacccgggac acccacaccg gcacaacctt
    11821 acgggagtga ttcactgtca aagaatcggc ccggtgctct gacgcaagta tcgggatggt
    11881 caccatttgt aagccgtaga cctgagtggt gatcaagact tcgataccac cgaccgtacc
    11941 ggtactaatc gacgacggtc gtgttcgtcg cctgccgcag ggactctgca cacctccgtt
    12001 tacgcatgtg cctggaggag ttggaaatcg tcgtgttcgg gaaacattaa acacaggatg
    12061 gcagcgatct gagccagcac atgatcagct agctcaccat ccggatcgac ggcccactgc
    12121 atcgtcgcgc cagcgatgac cgagtgcagg agcaactcag ctgccgcagg agcacctggg
    12181 ggcagtcgct tgcggatccc ctccaccacc gcgcggttcc gctggatcgc aagcgtgcgt
    12241 agctccggca cctggagctc gtaccaggag atgagatagt tcaccgagaa gtcgttgcga
    12301 gtgttcatgc tccgaacgag cacctgcaaa aattcccaga gcccttgcgg ccctgcgcct
    12361 atcggtatcg cattcaggta atgccgcacc tgctcgacgc cgcgctccat catcctcacc
    12421 agcagcgtat cgcggttggt gaagcgctgg attaacgctg cgcgggagag ccccacctcc
    12481 tttgctactc cgctgagcgt gaactctatg ggaccgcaac gcttcagcac tacggtggcg
    12541 gcctcgagta cctcgtcatc ggacttgagc ttggggcggg gcatcagtgt tcaccttctg
    12601 tatgggttgg ggcggaggct gtggctgccg ccgccattgt agcaaattga agacggagcg
    12661 agagtagagc cacgagcccc gcaaacacgg ccgatacaac gaggccaggg agcggaccag
    12721 caaggtcgac aaacgcgccg gccgcaagca taaccatggg cgaggctgac agcatcaccg
    12781 ccgagaccgt gccgagtacc cggccgagaa gttctggcgg cgtgcggttg tagatggcag
    12841 cgttgagaat gggagagact gagccggtca gcagtcccac gagcgcgccc aacaacatca
    12901 gcaccggcac gcctggcaac tgtgaaagca gaagcgagcc caccgcagag ccacaaaatg
    12961 ccaccgccag ccagttctgc gctgatatcc gggcgccgac cgacgcatga atggcaatgc
    13021 caaggagacc accagccccc atcattgagg agaacagccc gagctctgct acttggcgtc
    13081 ctgcatctac aaacagcgca ggcatgatga cgctgccgtt ggcgccaacg atgcccacga
    13141 agatcatcac tataccaaag agagggcgca gcaggggttc gctccagaga aaagcgacgc
    13201 cggcgcgcat ggagagagtc gccgtcgtgg tcatcgtccg agcggcacgc gcgggaagca
    13261 cccacgcgcc gagcagacct gcaaggacgg agcagaacgc cgtcagcccg agcgttggcg
    13321 cagcgccaag caggccgatt gcggcccccc caagggccgg gccacctaga atcgcgacgt
    13381 tcccgatcac cgctttcagt gacgagacgc gctcaacgga gagcccggcg acgtggccga
    13441 gtttgggcag ctcactgtcc tgcgcggcca taccgggtgc gtcgaacgcg gcaccgagca
    13501 ccacgcaagc gatcagccca gtgttcgaga gggcgccaac ggcatcgagc agtgggatgc
    13561 tcgccatggc cacgccgccc accacacccg agatcaatgc gacgggcgcg cgcccgaacc
    13621 gatcgacgag gccaccacca acccacgcgc cgatgatggt cgcgatgacg ctgctagcgg
    13681 ccgtggcgcc cgcccaggcc gcgctctttg tatgagacag gacgaaccat ggaagcgcga
    13741 gggccgccac cgcgttgccg atccggaaga gaaaggtcgc cgcgaacagc gtcgcgagcg
    13801 ggctatatcg acgttcgctc attccgctgc ggcgagctgc gccttcgccg cagcgaggta
    13861 ctcttcgtta cccgagtcga gggcgaagag tgcgtaggtg accgccccga acgcaaggcg
    13921 ctccgcgatg tggtgggcga gccgcggcca cacccggcca ccggccgctt catacgtgag
    13981 gaggagcttc gcgagcccct cttcaccaaa gaccataagg tgcgcggcca tgtcgatggc
    14041 agggtcatca acgcgggcct cgctccagtc gatcatcccg ctgacgcgct ccgtgttgtc
    14101 gatgagcaca tggcccacgt agagatcgcc atgcaccacc acggagaaat ctggccacga
    14161 cgaatcgtcg tcgagccagc gctgccaccg gtggaggcgc ttgtcgttca ccacgaactc
    14221 gcgtcggacg cggtcaacgt cgtcggccac cttctgacgg gcctgcgtcg gtgtacggat
    14281 gagcatcccc gcatccacgg cggcggaaat ggggacggca tgcagggcgg cgagcgcggt
    14341 cgcgaagctc tccgcgaaga cctccgagtc ctgcggcacg acccagtcgg gcgtggacga
    14401 accaggctgg atgaccatcg cagtcgagtc ttcgagcatg ggataggcaa cgagctcggc
    14461 gttggccacg cgccagtccg gcaccgcgaa cggcaggcga ttcttgagca ttgccagcac
    14521 ccgcgcctct ggttcgacct tcgcgcttac ctcggctcgg cgcgggatgc gcagcaccca
    14581 ccgacgtcca tcgtcgacgg tggcgatcac gatcctatag tcgagcccaa gctcattgac
    14641 agtcagcggg ccatggagct tgagcccatg tcgggctgca agtgcgtaca gttgggaggt
    14701 atcggcggtc gtgactacgg tcatgattca ctcctgaggg cttgacgggt ttagccacct
    14761 aaatgtaaca gtcacgtcgg ttatattcaa tccggcactg ttgcaaagtt agcgatgagg
    14821 cagccttttg tcttattcaa aggccttaca tttcaaaaac tctgcttacc aggcgcattt
    14881 cgcccagggg atcaccataa taaaatgctg aggcctggcc tttgcgtagt gcacgcatca
    14941 cctcaatacc tttgatggtg gcgtaagccg tcttcatgga tttaaatccc agcgtggcgc
    15001 cgattatccg tttcagtttg ccatgatcgc attcaatcac gttgttccgg tacttaatct
    15061 gtcggtgttc aacgtcagac gggcaccggc cttcgcgttt gagcagagca agcgcgcgac
    15121 cataggcggg cgctttatcc gtgttgatga atcgcgggat ctgccacttc ttcacgttgt
    15181 tgaggatttt acccagaaac cggtatgcag ctttgctgtt acgacgggag gagagataaa
    15241 aatcgacagt gcggccccgg ctgtcgacgg cccggtacag atacgcccag cggccattga
    15301 ccttcacgta ggtttcatcc atgtgccacg ggcaaagatc ggaagggtta cgccagtacc
    15361 agcgcagccg tttttccatt tcaggcgcat aacgctgaac ccagcggtaa atcgtggagt
    15421 gatcgacatt cactccgcgt tcagccagca tctcctgcag ctcacggtaa ctgatgccgt
    15481 atttgcagta ccagcgtacg gcccacagaa tgatgtcacg ctgaaaatgc cggcctttga
    15541 atgggttcat gtgcagctcc atcagcaaaa ggggatgata agtttatcac caccgactat
    15601 ttgcaacagt gcccaccgaa ctgaagctca cgccgcgccg gatagcgcca aggcactact
    15661 tcgcttcgag cgacaacagt tagctccagc ggtcgccatg ttccgccatc gcctggcggt
    15721 gatgagactt tcagcaaatc gagcattagc gcctgccgga gcgaatcgtt aggtgcggcg
    15781 ctgacggtca cgagcaagtc tatgtcgctg tccggcttca gccctccatc gatcgcagat
    15841 ccgaacaggt ggattgtgtc cagtgtcgca gccagatggc gctcgatcac cgcgcgagcg
    15901 tgggacagct gcttgaaaac ttgtgcaggg aaaaattcac ccatgatgcc taacgttaag
    15961 ttcagcggca gcttttaagt tgcggctttg tggaatactt ttgcgcagca aaaccacaaa
    16021 gacgcgactt aaaagctgtc caaggagcga agcgactggt gctgcaacgc attgttagcc
    16081 ttttttccaa atctggtatg tataatttat attagacata aaaaactgtt caaaaaccaa
    16141 attgaaattc tcaggcatta tagggaattt gatatcacct tcgacttcaa cgtgaacagt
    16201 agacaaatga attatatctg ctttttcaat aaggctatta tagatttgac ccccgccaga
    16261 gacatataca tgatctgtaa cttttgatag ctctttcaaa gcattttcta ttgaaggaaa
    16321 aactaggacg ttttcatttg agcttgaaat tccgttcttt gacactactg catatttgcg
    16381 atttggaaga acacccatag agtcaaatgt ttttcttccg acaaggagcc attgattata
    16441 tgtgagcgct ttaaagagta gttgctcacc ttttactgac cacgggatat caggaccact
    16501 accgattacg ccattttctg acactgcaga aatcaatgat attttcaatt taactccctt
    16561 aatggctaac tttgttttag ggcgactgcc ctgctgcgta acatcgttgc tgctccataa
    16621 catcaaacat cgacccacgg cgtaacgcgc ttgctgcttg gatgcccgag gcatagactg
    16681 tacaaaaaaa cagtcataac aagccatgaa aaccgccact gcgccgttac caccgctgcg
    16741 ttcggtcaag gttctggacc agttgcgtga gcgcatacgc tacttgcatt acagtttacg
    16801 aaccgaacag gcttatgtcc actgggttcg tgccttcatc cgtttccacg gtgtgcgtca
    16861 cccggcaacc ttgggcagca gcgaagtcga ggcatttctg tcctggctgg cgaacgagcg
    16921 caaggtttcg gtctccacgc atcgtcaggc attggcggcc ttgctgttct tctacggcaa
    16981 ggtgctgtgc acggatctgc cctggcttca ggagatcgga agacctcggc cgtcgcggcg
    17041 cttgccggtg gtgctgaccc cggatgaagt ggttcgcatc ctcggttttc tggaaggcga
    17101 gcatcgtttg ttcgcccagc ttctgtatgg aacgggcatg cggatcagtg agggtttgca
    17161 actgcgggtc aaggatctgg atttcgatca cggcacgatc atcgtgcggg agggcaaggg
    17221 ctccaaggat cgggccttga tgttacccga gagcttggca cccagcctgc gcgagcagct
    17281 gtcgcgtgca cgggcatggt ggctgaagga ccaggccgag ggccgcagcg gcgttgcgct
    17341 tcccgacgcc cttgagcgga agtatccgcg cgccgggcat tcctggcggc actgttgcaa
    17401 atagtcggtg gtgataaact tatcatcccc ttttgctgat ggagctgcac atgaacccat
    17461 tcaaaggccg gcattttcag cgtgacatca ttctgtgggc cgtacgctgg tactgcaaat
    17521 acggcatcag ttaccgtgag ctgcaggaga tgctggctga acgcggagtg aatgtcgatc
    17581 actccacgat ttaccgctgg gttcagcgtt atgcgcctga aatggaaaaa cggctgcgct
    17641 ggtactggcg taacccttcc gatctttgcc cgtggcacat ggatgaaacc tacgtgaagg
    17701 tcaatggccg ctgggcgtat ctgtaccggg ccgtcgacag ccggggccgc actgtcgatt
    17761 tttatctctc ctcccgtcgt aacagcaaag ctgcataccg gtttctgggt aaaatcctca
    17821 acaacgtgaa gaagtggcag atcccgcgat tcatcaacac ggataaagcg cccgcctatg
    17881 gtcgcgcgct tgctctgctc aaacgcgaag gccggtgccc gtctgacgtt gaacaccgac
    17941 agattaagta ccggaacaac gtgattgaat gcgatcatgg caaactgaaa cggataatcg
    18001 gcgccacgct gggatttaaa tccatgaaga cggcttacgc caccatcaaa ggtattgagg
    18061 tgatgcgtgc actacgcaaa ggccaggcat cagcatttta ttatggtgat cccctgggcg
    18121 aaatgcgcct ggtaagcaga gtttttgaaa tgtaaggcct ttgaataaga caaaaggctg
    18181 cctcatcgct aactttgcaa cagtgcc
//
