LOCUS       NZ_CP148333            18375 bp    DNA     circular CON 15-APR-2024
DEFINITION  Escherichia coli strain Z1323HEC0462 plasmid pZ1323HEC0462-3,
            complete sequence.
ACCESSION   NZ_CP148333
VERSION     NZ_CP148333.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN40441602
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Escherichia.
REFERENCE   1  (bases 1 to 18375)
  AUTHORS   Chae,J.-C., Oh,J.Y., Jeong,J.H. and Kwak,S.M.
  TITLE     Complete genome sequence of Escherichia coli isolated from humans,
            companion animals, industrial animals and wild animals
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 18375)
  AUTHORS   Chae,J.-C., Oh,J.Y., Jeong,J.H. and Kwak,S.M.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-MAR-2024) Division of biotechnology, Jeonbuk National
            University, kobongro, Iksan 54596, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. v0.4.9
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 106X
            Sequencing Technology :: Illumina NovaSeq; Oxford Nanopore MinION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_038096585.1-RS_2024_04_15
            Annotation Date                   :: 04/15/2024 11:28:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 27
            CDSs (total)                      :: 27
            Genes (coding)                    :: 23
            CDSs (with protein)               :: 23
            Genes (RNA)                       :: 0
            tRNAs                             :: 0
            ncRNAs                            :: 0
            Pseudo Genes (total)              :: 4
            CDSs (without protein)            :: 4
            Pseudo Genes (ambiguous residues) :: 0 of 4
            Pseudo Genes (frameshifted)       :: 0 of 4
            Pseudo Genes (incomplete)         :: 4 of 4
            Pseudo Genes (internal stop)      :: 0 of 4
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP148333.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..18375
                     /organism="Escherichia coli"
                     /mol_type="genomic DNA"
                     /strain="Z1323HEC0462"
                     /host="Homo sapiens"
                     /db_xref="taxon:562"
                     /plasmid="pZ1323HEC0462-3"
                     /geo_loc_name="South Korea"
                     /collection_date="2023-05-20"
     gene            70..975
                     /locus_tag="WHU15_RS00005"
                     /old_locus_tag="WHU15_23670"
     CDS             70..975
                     /locus_tag="WHU15_RS00005"
                     /old_locus_tag="WHU15_23670"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000219391.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Mph(A) family macrolide 2'-phosphotransferase"
                     /protein_id="WP_000219391.1"
                     /translation="MTVVTTADTSQLYALAARHGLKLHGPLTVNELGLDYRIVIATVDD
                     GRRWVLRIPRRAEVSAKVEPEARVLAMLKNRLPFAVPDWRVANAELVAYPMLEDSTAMV
                     IQPGSSTPDWVVPQDSEVFAESFATALAALHAVPISAAVDAGMLIRTPTQARQKVADDV
                     DRVRREFVVNDKRLHRWQRWLDDDSSWPDFSVVVHGDLYVGHVLIDNTERVSGMIDWSE
                     ARVDDPAIDMAAHLMVFGEEGLAKLLLTYEAAGGRVWPRLAHHIAERLAFGAVTYALFA
                     LDSGNEEYLAAAKAQLAAAE"
                     /name="Mph(A) family macrolide 2'-phosphotransferase"
     gene            972..2210
                     /gene="mrx(A)"
                     /locus_tag="WHU15_RS00010"
                     /old_locus_tag="WHU15_23675"
                     /gene_synonym="mrx"
     CDS             972..2210
                     /gene="mrx(A)"
                     /locus_tag="WHU15_RS00010"
                     /old_locus_tag="WHU15_23675"
                     /gene_synonym="mrx"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000004159.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="macrolide resistance MFS transporter Mrx(A)"
                     /protein_id="WP_000004159.1"
                     /translation="MSERRYSPLATLFAATFLFRIGNAVAALALPWFVLSHTKSAAWAG
                     ATAASSVIATIIGAWVGGGLVDRFGRAPVALISGVVGGVAMASIPLLDAVGALSNTGLI
                     ACVVLGAAFDAPGMAAQDSELPKLGHVAGLSVERVSSLKAVIGNVAILGGPALGGAAIG
                     LLGAAPTLGLTAFCSVLAGLLGAWVLPARAARTMTTTATLSMRAGVAFLWSEPLLRPLF
                     GIVMIFVGIVGANGSVIMPALFVDAGRQVAELGLFSSMMGAGGLLGIAIHASVGARISA
                     QNWLAVAFCGSAVGSLLLSQLPGVPVLMLLGALVGLLTGSVSPILNAAIYNRTPPELLG
                     RVLGTVSAVMLSASPMVMLAAGAFVDLAGPLPGLVVSAVFAGLVALLSLRLQFATMAAA
                     ATASAPTHTEGEH"
                     /name="mrx(A)"
     gene            2210..2794
                     /gene="mphR(A)"
                     /locus_tag="WHU15_RS00015"
                     /old_locus_tag="WHU15_23680"
     CDS             2210..2794
                     /gene="mphR(A)"
                     /locus_tag="WHU15_RS00015"
                     /old_locus_tag="WHU15_23680"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001137892.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="macrolide-binding transcriptional repressor
                     MphR(A)"
                     /protein_id="WP_001137892.1"
                     /translation="MPRPKLKSDDEVLEAATVVLKRCGPIEFTLSGVAKEVGLSRAALI
                     QRFTNRDTLLVRMMERGVEQVRHYLNAIPIGAGPQGLWEFLQVLVRSMNTRNDFSVNYL
                     ISWYELQVPELRTLAIQRNRAVVEGIRKRLPPGAPAAAELLLHSVIAGATMQWAVDPDG
                     ELADHVLAQIAAILCLMFPEHDDFQLLQAHA"
                     /name="mphR(A)"
     gene            complement(3287..4051)
                     /locus_tag="WHU15_RS00020"
                     /old_locus_tag="WHU15_23685"
     CDS             complement(3287..4051)
                     /locus_tag="WHU15_RS00020"
                     /old_locus_tag="WHU15_23685"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001389365.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS6100 family transposase"
                     /protein_id="WP_001389365.1"
                     /translation="MTDFKWRHFQGDVILWAVRWYCRYPISYRDLEEMLAERGISVDHT
                     TIYRWVQCYAPEMEKRLRWFWRRGFDPSWRLDETYVKVRGKWTYLYRAVDKRGDTIDFY
                     LSPTRSAKAAKRFLGKALRGLKHWEKPATLNTDKAPSYGAAITELKREGKLDRETAHRQ
                     VKYLNNVIEADHGKLKILIKPVRGFKSIPTAYATIKGFEVMRALRKGQARPWCLQPGIR
                     GEVRLVERAFGIGPSALTEAMGMLNHHFAAAA"
                     /name="IS6-like element IS6100 family transposase"
     gene            complement(4169..>4234)
                     /locus_tag="WHU15_RS00025"
                     /old_locus_tag="WHU15_23690"
                     /pseudo=""
     CDS             complement(4169..>4234)
                     /locus_tag="WHU15_RS00025"
                     /old_locus_tag="WHU15_23690"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_005229646.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="EAL domain-containing protein"
                     /name="EAL domain-containing protein"
     gene            complement(4278..4583)
                     /locus_tag="WHU15_RS00030"
                     /old_locus_tag="WHU15_23695"
     CDS             complement(4278..4583)
                     /locus_tag="WHU15_RS00030"
                     /old_locus_tag="WHU15_23695"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000130000.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PadR family transcriptional regulator"
                     /protein_id="WP_000130000.1"
                     /translation="MTDKDLYGGLIRLHILHHAAEEPVFGLGIIEELRRHGYEMSAGTV
                     YPMLHGLEKKGYLTSRHERTGRRERRVYDITEQGRTALADAKTKVKELFGELVEGG"
                     /name="PadR family transcriptional regulator"
     gene            complement(4594..5799)
                     /gene="chrA"
                     /locus_tag="WHU15_RS00035"
                     /old_locus_tag="WHU15_23700"
     CDS             complement(4594..5799)
                     /gene="chrA"
                     /locus_tag="WHU15_RS00035"
                     /old_locus_tag="WHU15_23700"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004896675.1"
                     /GO_function="GO:0015109 - chromate transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0015703 - chromate transport [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chromate efflux transporter"
                     /protein_id="WP_000184001.1"
                     /translation="MTNNPTDDSRPWSVFLIFLRLGLTSFGGPIAHLGYFRAEFVTRRR
                     WLSERSYADLVALCQFLPGPASSQVGIAVGLSRAGYSGALAAWAGFTLPSAIALILFAL
                     GISSYGDYVSQGALHGLKVVAVAVVAQAVWGMARNLCTDGLRVTIMAIATCVVLLVPSA
                     WGQVGVIAIAGIAGRLLFKPAKVVEHDPLPITVSHRAGVLWLSLFFVLLIGLPVLAELM
                     PSQTMAMVDSFYRVGSLVFGGGHVVLPLLQAEVVPSGWVNNESFLAGYGAAQAVPGPLF
                     TFAAFLGASMNTAPSGWIGGIVCLLAIFAPSFLLVVGSMPFWERLRRNTGIQAALAGIN
                     AAVVGLLLAALYQPVWTSAIFQPQDFGLALVALVALMFWKLPPWLVVLGSGAAGWLLSV
                     AL"
                     /name="chrA"
     gene            complement(5955..6158)
                     /locus_tag="WHU15_RS00040"
                     /old_locus_tag="WHU15_23705"
     CDS             complement(5955..6158)
                     /locus_tag="WHU15_RS00040"
                     /old_locus_tag="WHU15_23705"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000376616.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000376616.1"
                     /translation="MDSEEPPNVRVACSGDIDEVVRLMHDAAAWMSAKGTPAWDVARID
                     RTFAETFVLRSELLGIASENGK"
                     /name="hypothetical protein"
     gene            complement(6286..7125)
                     /gene="sul1"
                     /locus_tag="WHU15_RS00045"
                     /old_locus_tag="WHU15_23710"
     ARG             complement(6290..7125)
                     /name="sul1"
                     /gene="sul1"
                     /gene_name="sulfonamide-resistant dihydropteroate synthase
                     Sul1"
                     /tool="amrfinderplus"
                     /drug_class="SULFONAMIDE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(7119..7454)
                     /locus_tag="WHU15_RS00050"
                     /old_locus_tag="WHU15_23715"
     CDS             complement(7119..7454)
                     /locus_tag="WHU15_RS00050"
                     /old_locus_tag="WHU15_23715"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000679428.1"
                     /GO_component="GO:0016020 - membrane [Evidence IEA];
                     GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SMR family transporter"
                     /protein_id="WP_052238321.1"
                     /translation="MRYPRNAVLFSLFADNVRRTEGFTKLAPSAVVIIGYGIAFYFLSL
                     VLKSIPVGVAYAVWSGLGVVIITAIAWLLHGQKLDAWGFVGMGLIIAAFLLARSPSWKS
                     LRRPTPW"
                     /name="SMR family transporter"
     gene            7347..7712
                     /gene="hypA"
                     /locus_tag="WHU15_RS00055"
                     /old_locus_tag="WHU15_23720"
     CDS             7347..7712
                     /gene="hypA"
                     /locus_tag="WHU15_RS00055"
                     /old_locus_tag="WHU15_23720"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004193196.1"
                     /GO_function="GO:0008901 - ferredoxin hydrogenase activity
                     [Evidence IEA]"
                     /GO_process="GO:0036211 - protein modification process
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydrogenase maturation nickel metallochaperone
                     HypA"
                     /protein_id="WP_025999322.1"
                     /translation="MTDYDNGGRGKLSKALGAADIIREQAEQHGIARVTDVWLEVGALA
                     DVEESALHFCFDIACRDTVAQGCTLHIDVIPAQAWCWDCSREAEIMQHAGCCPHCGSER
                     LRISEGDDLRVKSLEGE"
                     /name="hypA"
     gene            complement(7716..8591)
                     /gene="ampR"
                     /locus_tag="WHU15_RS00060"
                     /old_locus_tag="WHU15_23725"
     CDS             complement(7716..8591)
                     /gene="ampR"
                     /locus_tag="WHU15_RS00060"
                     /old_locus_tag="WHU15_23725"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004236384.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator AmpR"
                     /protein_id="WP_004193231.1"
                     /translation="MVRRYLPLNPLRAFEAAARHLSFTRAAIELNVTHAAVSQQVRALE
                     EQLGCVLFTRVSRGLVLTHEGEGLLPVLNEAFDRIADTLECFSHGQFRERVKVGAVGTF
                     AAGWLLPRLAGFYDSHPHIDLHISTHNNHVDPAAEGHDYTIRFGNGAWHESDAELIFSA
                     PHAPLCSPAIAEQLQQPDDVHRFTLLRSFRRDEWSRWLDCAGGTPPSPSQPVMVFDTSL
                     AMAEAAQLGAGVAIAPVCMFSRLLQSGALVQPFAAEITLGGYWLTRLQSRTETPAMQQF
                     ARWLLNTAAA"
                     /name="ampR"
     gene            8702..9841
                     /locus_tag="WHU15_RS00065"
                     /old_locus_tag="WHU15_23730"
     CDS             8702..9841
                     /locus_tag="WHU15_RS00065"
                     /old_locus_tag="WHU15_23730"
                     /EC_number="3.5.2.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032097955.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="extended-spectrum class C beta-lactamase DHA-1"
                     /protein_id="WP_004236386.1"
                     /translation="MKKSLSATLISALLAFSAPGFSAADNVAAVVDSTIKPLMAQQDIP
                     GMAVAVSVKGKPYYFNYGFADIQAKQPVTENTLFELGSVSKTFTGVLGAVSVAKKEMAL
                     NDPAAKYQPELALPQWKGITLLDLATYTAGGLPLQVPDAVKSRADLLNFYQQWQPSRKP
                     GDMRLYANSSIGLFGALTANAAGMPYEQLLTARILAPLGLSHTFITVPESAQSQYAYGY
                     KNKKPVRVSPGQLDAESYGVKSASKDMLRWAEMNMEPSRAGNADLEMAMYLAQTRYYKT
                     AAINQGLGWEMYDWPQQKDMIINGVTNEVALQPHPVTDNQVQPYNRASWVHKTGATTGF
                     GAYVAFIPEKQVAIVILANKNYPNTERVKAAQAILSALE"
                     /name="extended-spectrum class C beta-lactamase DHA-1"
     gene            10036..10857
                     /locus_tag="WHU15_RS00070"
                     /old_locus_tag="WHU15_23735"
     CDS             10036..10857
                     /locus_tag="WHU15_RS00070"
                     /old_locus_tag="WHU15_23735"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_013214003.1"
                     /translation="MDVLRFILRLPFILLRLAARSLVYLFTLLGFLLRPFTGRIRWAVP
                     GWVTFAGNQLARLERGGNRYPKTISALLLLTAAVAAGSYYTWHWYQNKPKPVDVAPLVV
                     QDISASVQRPSAVNYNRDDNSAQIVVVTFSRSAAPVTLIGKPVTAGITLTPAMEGEWQW
                     RNDRKLVFTAKKTFPMGKTYTVDMDAKTLLAPQVALTEKQKTFTTPEFYYRGGRAEFYQ
                     DPQDPMKKHAIIGLTFNAPADVKNLESRLSMTRDGKPVPYTVTVMNCCHLC"
                     /name="hypothetical protein"
     gene            <10815..11003
                     /locus_tag="WHU15_RS00075"
                     /old_locus_tag="WHU15_23740"
                     /pseudo=""
     CDS             <10815..11003
                     /locus_tag="WHU15_RS00075"
                     /old_locus_tag="WHU15_23740"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000075350.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="LacI family transcriptional regulator"
                     /name="LacI family transcriptional regulator"
     gene            complement(11192..11422)
                     /gene="pspD"
                     /locus_tag="WHU15_RS00080"
                     /old_locus_tag="WHU15_23745"
     CDS             complement(11192..11422)
                     /gene="pspD"
                     /locus_tag="WHU15_RS00080"
                     /old_locus_tag="WHU15_23745"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003833267.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage shock protein PspD"
                     /protein_id="WP_004193241.1"
                     /translation="MNNRWQRAGQRVKPGIKIAGKLVLLTALRYGPAGVAGWAVKSVAR
                     RPLKMLLALVLEPLLSRAATKLSKRYSGNQP"
                     /name="pspD"
     gene            complement(11431..11790)
                     /gene="pspC"
                     /locus_tag="WHU15_RS00085"
                     /old_locus_tag="WHU15_23750"
     CDS             complement(11431..11790)
                     /gene="pspC"
                     /locus_tag="WHU15_RS00085"
                     /old_locus_tag="WHU15_23750"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_460646.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="envelope stress response membrane protein PspC"
                     /protein_id="WP_004193243.1"
                     /translation="MGGVNLNKKLWRIPQQGMVKGVCAGIAHYLDVPVKLVRILVVLSI
                     FFGLAFFTFVAYIVLTFVLDPMPDNVVSGEQQPSSGELLDAVDRELAASEKRLREMERY
                     VTSDTFTLRSRFRQL"
                     /name="pspC"
     gene            complement(11790..12014)
                     /gene="pspB"
                     /locus_tag="WHU15_RS00090"
                     /old_locus_tag="WHU15_23755"
     CDS             complement(11790..12014)
                     /gene="pspB"
                     /locus_tag="WHU15_RS00090"
                     /old_locus_tag="WHU15_23755"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_460647.1"
                     /GO_process="GO:0009271 - phage shock [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="envelope stress response membrane protein PspB"
                     /protein_id="WP_004193245.1"
                     /translation="MSALFLAIPLTIFVLFVLPIWLWLHYSNRSSRGELAQSEQQRLVE
                     LNQDAQRMRERIQALEDILDAEHPNWRDR"
                     /name="pspB"
     gene            complement(12069..12737)
                     /gene="pspA"
                     /locus_tag="WHU15_RS00095"
                     /old_locus_tag="WHU15_23760"
     CDS             complement(12069..12737)
                     /gene="pspA"
                     /locus_tag="WHU15_RS00095"
                     /old_locus_tag="WHU15_23760"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_460648.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage shock protein PspA"
                     /protein_id="WP_003020532.1"
                     /translation="MGIFSRFADIVNANINALLEKAEDPQKLVRLMIQEMEDTLVEVRS
                     NSARALAEKKQLSRRIEQASAQQAEWQEKAELALRKEKEDLARSALIEKQKLTDLIASL
                     EHEVTLVDDTLARMKKEIGELENKLSETRARQQALMLRHQAASSSRDVRRQLDSGKLDE
                     AMARFESFERRIDQMEAEAESHNFGKQKSLDQQFADLKADDEISEQLAQLKAKMQQDKQ
                     "
                     /name="pspA"
     gene            12908..13882
                     /gene="pspF"
                     /locus_tag="WHU15_RS00100"
                     /old_locus_tag="WHU15_23765"
     CDS             12908..13882
                     /gene="pspF"
                     /locus_tag="WHU15_RS00100"
                     /old_locus_tag="WHU15_23765"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_309907.2"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phage shock protein operon transcriptional
                     activator"
                     /protein_id="WP_004193248.1"
                     /translation="MAGYKDNLLGEANSFIEVLEQVSRLAPLDKPVLVIGERGTGKELI
                     ANRLHYLSTRWQGPFISLNCAALNENLLDSELFGHEAGAFTGAQKRHPGRFERADGGTL
                     FLDELATAPMLVQEKLLRVIEYGELERVGGSQPLQVNVRLVCATNADLPRMVSEGTFRA
                     DLLDRLAFDVVQLPPLRERQSDIMLMAEHFAIQMCREIGLPLFPGFTDEAKETLLHYRW
                     PGNIRELKNVVERSVYRHGTSDYPLNEIVIDPFRRHAAPPLAQETRHTSVTLPLDLREF
                     QQQQEKEFLQTSLQQAKFNQKKAAELLGLTYHQLRALLKKHQI"
                     /name="pspF"
     gene            13965..14609
                     /locus_tag="WHU15_RS00105"
                     /old_locus_tag="WHU15_23770"
     CDS             13965..14609
                     /locus_tag="WHU15_RS00105"
                     /old_locus_tag="WHU15_23770"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017900990.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="quinolone resistance pentapeptide repeat protein
                     QnrB4"
                     /protein_id="WP_017900990.1"
                     /translation="MTLALVGEKIDRNRFTGEKVENSTFFNCDFSGADLSGTEFIGCQF
                     YDRESQKGCNFSRANLKDAIFKSCDLSMADFRNINALGIEIRHCRAQGSDFRGASFMNM
                     ITTRTWFCSAYITNTNLSYANFSKVVLEKCELWENRWMGTQVLGATFSGSDLSGGEFSS
                     FDWRAANVTHCDLTNSELGDLDIRGVDLQGVKLDSYQASLLLERLGIAVMG"
                     /name="quinolone resistance pentapeptide repeat protein
                     QnrB4"
     gene            complement(14705..15004)
                     /locus_tag="WHU15_RS00110"
                     /old_locus_tag="WHU15_23775"
     CDS             complement(14705..15004)
                     /locus_tag="WHU15_RS00110"
                     /old_locus_tag="WHU15_23775"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015965699.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_256737713.1"
                     /translation="MRQKAASSLTLQQCPKSLAKQLAPKGIRVNAVAPGPYWTVLQCCG
                     GQPQEKIEKFGANAPLGRPGQPVEIAPLYVTLAAEENSYTSGQVWCSDGGTGTL"
                     /name="SDR family oxidoreductase"
     gene            complement(15014..15718)
                     /locus_tag="WHU15_RS00115"
                     /old_locus_tag="WHU15_23780"
     CDS             complement(15014..15718)
                     /locus_tag="WHU15_RS00115"
                     /old_locus_tag="WHU15_23780"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_005221000.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS26 family transposase"
                     /protein_id="WP_001067855.1"
                     /translation="MNPFKGRHFQRDIILWAVRWYCKYGISYRELQEMLAERGVNVDHS
                     TIYRWVQRYAPEMEKRLRWYWRNPSDLCPWHMDETYVKVNGRWAYLYRAVDSRGRTVDF
                     YLSSRRNSKAAYRFLGKILNNVKKWQIPRFINTDKAPAYGRALALLKREGRCPSDVEHR
                     QIKYRNNVIECDHGKLKRIIGATLGFKSMKTAYATIKGIEVMRALRKGQASAFYYGDPL
                     GEMRLVSRVFEM"
                     /name="IS6-like element IS26 family transposase"
     gene            complement(<15786..16112)
                     /locus_tag="WHU15_RS00120"
                     /old_locus_tag="WHU15_23785"
                     /pseudo=""
     CDS             complement(<15786..16112)
                     /locus_tag="WHU15_RS00120"
                     /old_locus_tag="WHU15_23785"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000503573.1"
                     /GO_function="GO:0016779 - nucleotidyltransferase activity
                     [Evidence IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotidyltransferase domain-containing protein"
                     /name="nucleotidyltransferase domain-containing protein"
     ARG             complement(16244..16842)
                     /name="dfrA17"
                     /gene="dfrA17"
                     /gene_name="trimethoprim resistant dihydrofolate reductase
                     dfr"
                     /tool="rgi"
                     /drug_class="diaminopyrimidine antibiotic"
                     /identity="99.36"
                     /coverage="126.75"
     ARG             complement(16247..16716)
                     /name="dfrA17"
                     /gene="dfrA17"
                     /gene_name="trimethoprim-resistant dihydrofolate reductase
                     DfrA17"
                     /tool="amrfinderplus"
                     /drug_class="TRIMETHOPRIM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            16874..>17554
                     /gene="intI1"
                     /locus_tag="WHU15_RS00130"
                     /old_locus_tag="WHU15_23795"
                     /pseudo=""
     CDS             16874..>17554
                     /gene="intI1"
                     /locus_tag="WHU15_RS00130"
                     /old_locus_tag="WHU15_23795"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_005221021.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="class 1 integron integrase IntI1"
                     /name="intI1"
     gene            17619..18323
                     /locus_tag="WHU15_RS00135"
                     /old_locus_tag="WHU15_23800"
     CDS             17619..18323
                     /locus_tag="WHU15_RS00135"
                     /old_locus_tag="WHU15_23800"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_005221000.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS26 family transposase"
                     /protein_id="WP_001067855.1"
                     /translation="MNPFKGRHFQRDIILWAVRWYCKYGISYRELQEMLAERGVNVDHS
                     TIYRWVQRYAPEMEKRLRWYWRNPSDLCPWHMDETYVKVNGRWAYLYRAVDSRGRTVDF
                     YLSSRRNSKAAYRFLGKILNNVKKWQIPRFINTDKAPAYGRALALLKREGRCPSDVEHR
                     QIKYRNNVIECDHGKLKRIIGATLGFKSMKTAYATIKGIEVMRALRKGQASAFYYGDPL
                     GEMRLVSRVFEM"
                     /name="IS6-like element IS26 family transposase"
     ARG             13966..14606
                     /name="qnrB4"
                     /gene="qnrB4"
                     /gene_name="quinolone resistance pentapeptide repeat
                     protein QnrB4"
                     /tool="amrfinderplus"
                     /drug_class="QUINOLONE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             71..972
                     /name="mph(A)"
                     /gene="mph(A)"
                     /gene_name="Mph(A) family macrolide 2'-phosphotransferase"
                     /tool="amrfinderplus"
                     /drug_class="MACROLIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             8703..9838
                     /name="blaDHA-1"
                     /gene="blaDHA-1"
                     /gene_name="extended-spectrum class C beta-lactamase DHA-1"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             71..975
                     /name="mphA"
                     /gene="mphA"
                     /gene_name="macrolide phosphotransferase (MPH)"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             complement(15766..16112)
                     /name="aadA5"
                     /gene="aadA5"
                     /gene_name="ANT(3'')"
                     /tool="rgi"
                     /drug_class="aminoglycoside antibiotic"
                     /identity="100.0"
                     /coverage="43.89"
     ARG             973..2210
                     /name="Mrx"
                     /gene="Mrx"
                     /gene_name="macrolide phosphotransferase (MPH)"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic"
                     /identity="100.0"
                     /coverage="100.0"
ORIGIN
        1 ggattgaata taaccgacgt gactgttaca tttaggtggc taaacccgtc aagccctcag
       61 gagtgaatca tgaccgtagt cacgaccgcc gatacctccc aactgtacgc acttgcagcc
      121 cgacatgggc tcaagctcca tggcccgctg actgtcaatg agcttgggct cgactatagg
      181 atcgtgatcg ccaccgtcga cgatggacgt cggtgggtgc tgcgcatccc gcgccgagcc
      241 gaggtaagcg cgaaggtcga accagaggcg cgggtgctgg caatgctcaa gaatcgcctg
      301 ccgttcgcgg tgccggactg gcgcgtggcc aacgccgagc tcgttgccta tcccatgctc
      361 gaagactcga ctgcgatggt catccagcct ggttcgtcca cgcccgactg ggtcgtgccg
      421 caggactcgg aggtcttcgc ggagagcttc gcgaccgcgc tcgccgccct gcatgccgtc
      481 cccatttccg ccgccgtgga tgcggggatg ctcatccgta caccgacgca ggcccgtcag
      541 aaggtggccg acgacgttga ccgcgtccga cgcgagttcg tggtgaacga caagcgcctc
      601 caccggtggc agcgctggct cgacgacgat tcgtcgtggc cagatttctc cgtggtggtg
      661 catggcgatc tctacgtggg ccatgtgctc atcgacaaca cggagcgcgt cagcgggatg
      721 atcgactgga gcgaggcccg cgttgatgac cctgccatcg acatggccgc gcaccttatg
      781 gtctttggtg aagaggggct cgcgaagctc ctcctcacgt atgaagcggc cggtggccgg
      841 gtgtggccgc ggctcgccca ccacatcgcg gagcgccttg cgttcggggc ggtcacctac
      901 gcactcttcg ccctcgactc gggtaacgaa gagtacctcg ctgcggcgaa ggcgcagctc
      961 gccgcagcgg aatgagcgaa cgtcgatata gcccgctcgc gacgctgttc gcggcgacct
     1021 ttctcttccg gatcggcaac gcggtggcgg ccctcgcgct tccatggttc gtcctgtctc
     1081 atacaaagag cgcggcctgg gcgggcgcca cggccgctag cagcgtcatc gcgaccatca
     1141 tcggcgcgtg ggttggtggt ggcctcgtcg atcggttcgg gcgcgcgccc gtcgcattga
     1201 tctcgggtgt ggtgggcggc gtggccatgg cgagcatccc actgctcgat gccgttggcg
     1261 ccctctcgaa cactgggctg atcgcttgcg tggtgctcgg tgccgcgttc gacgcacccg
     1321 gtatggccgc gcaggacagt gagctgccca aactcggcca cgtcgccggg ctctccgttg
     1381 agcgcgtctc gtcactgaaa gcggtgatcg ggaacgtcgc gattctaggt ggcccggccc
     1441 ttgggggggc cgcaatcggc ctgcttggcg ctgcgccaac gctcgggctg acggcgttct
     1501 gctccgtcct tgcaggtctg ctcggcgcgt gggtgcttcc cgcgcgtgcc gctcggacga
     1561 tgaccacgac ggcgactctc tccatgcgcg ccggcgtcgc ttttctctgg agcgaacccc
     1621 tgctgcgccc tctctttggt atagtgatga tcttcgtggg catcgttggc gccaacggca
     1681 gcgtcatcat gcctgcgctg tttgtagatg caggacgcca agtagcagag ctcgggctgt
     1741 tctcctcaat gatgggggct ggtggtctcc ttggcattgc cattcatgcg tcggtcggcg
     1801 cccggatatc agcgcagaac tggctggcgg tggcattttg tggctctgcg gtgggctcgc
     1861 ttctgctttc acagttgcca ggcgtgccgg tgctgatgtt gttgggcgcg ctcgtgggac
     1921 tgctgaccgg ctcagtctct cccattctca acgctgccat ctacaaccgc acgccgccag
     1981 aacttctcgg ccgggtactc ggcacggtct cggcggtgat gctgtcagcc tcgcccatgg
     2041 ttatgcttgc ggccggcgcg tttgtcgacc ttgctggtcc gctccctggc ctcgttgtat
     2101 cggccgtgtt tgcggggctc gtggctctac tctcgctccg tcttcaattt gctacaatgg
     2161 cggcggcagc cacagcctcc gccccaaccc atacagaagg tgaacactga tgccccgccc
     2221 caagctcaag tccgatgacg aggtactcga ggccgccacc gtagtgctga agcgttgcgg
     2281 tcccatagag ttcacgctca gcggagtagc aaaggaggtg gggctctccc gcgcagcgtt
     2341 aatccagcgc ttcaccaacc gcgatacgct gctggtgagg atgatggagc gcggcgtcga
     2401 gcaggtgcgg cattacctga atgcgatacc gataggcgca gggccgcaag ggctctggga
     2461 atttttgcag gtgctcgttc ggagcatgaa cactcgcaac gacttctcgg tgaactatct
     2521 catctcctgg tacgagctcc aggtgccgga gctacgcacg cttgcgatcc agcggaaccg
     2581 cgcggtggtg gaggggatcc gcaagcgact gcccccaggt gctcctgcgg cagctgagtt
     2641 gctcctgcac tcggtcatcg ctggcgcgac gatgcagtgg gccgtcgatc cggatggtga
     2701 gctagctgat catgtgctgg ctcagatcgc tgccatcctg tgtttaatgt ttcccgaaca
     2761 cgacgatttc caactcctcc aggcacatgc gtaaacggag gtgtgcagag tccctgcggc
     2821 aggcgacgaa cacgaccgtc gtcgattagt accggtacgg tcggtggtat cgaagtcttg
     2881 atcaccactc aggtctacgg cttacaaatg gtgaccatcc cgatacttgc gtcagagcac
     2941 cgggccgatt ctttgacagt gaatcactcc cgtaaggttg tgccggtgtg ggtgtcccgg
     3001 gtcgagacga tactccgcca atgcgcccag caaacaacct ggccatcgca ggtggtgggg
     3061 agcggtgtgg cggatgagtt ggacaagttg gtgtagcagc acgagcacgg cgagataaca
     3121 tcgcaggagt tcgacatgct caagagacag ctgattgcga atcgcgatgc agattcataa
     3181 cccgattgcg ggttggcttc actccaccat caccgagcag actagcacgg cgggctctgt
     3241 tgcaaagatt ggcggcagtc agaggtaggc tgtcgctctg cgccgatcag gcggctgctg
     3301 cgaaatggtg gttgagcatg cccatggcct ccgtcagcgc cgagggccca atgccaaaag
     3361 ctctctccac aaggcgcacc tcgcccctga tgccgggctg caggcaccag gggcgagcct
     3421 gtcctttgcg cagggctcgc atgacttcga atcccttgat cgtggcatag gccgtgggga
     3481 tcgatttgaa accgcgcacc ggcttgatca gtatcttgag ctttccgtga tcggcctcga
     3541 tcacgttatt gagatacttc acctgccggt gggccgtctc ccggtccagc tttccttcgc
     3601 gcttcaattc ggtgatcgct gcaccatagc tcggcgcttt gtcggtattg agcgtggcag
     3661 gcttttccca gtgcttcagg cctcgcaggg ccttgcccag gaaccgcttc gctgccttgg
     3721 cgctgcgggt cggcgacagg tagaaatcga tcgtgtcgcc ccgcttgtcg actgcccggt
     3781 acaggtaggt ccacttgccc cgcaccttga cgtaggtttc atccaggcgc cagctcggat
     3841 caaagccacg ccgccagaac cagcgcagcc gcttctccat ctccggggcg tagcactgga
     3901 cccagcgata gatcgtcgta tggtcgaccg aaatgccgcg ttccgccagc atttcctcaa
     3961 ggtcgcgata gctgatcgga tagcgacaat accagcgcac cgcccacagg atcacatcac
     4021 cctggaaatg gcgccacttg aaatccgtca tcgttccgtc cgtccaatct ccgccaagca
     4081 tgctcaagct tcacgatttt tgcaacagag cccacacgag tattgagcat agtcgagatt
     4141 ggtgcagatc acttctgata ttgaactgtc aggagctggc tgcacaacag ccattacgcc
     4201 caatcaactg gtgcagtcgt cttctgaaaa tgacaatcca gttagggtat agctcaacct
     4261 gacatagaag caaaaactca accaccttct accaactctc cgaacagctc cttgaccttt
     4321 gttttcgcat cagcaagtgc agttctgcct tgttcagtga tgtcataaac acgccgttca
     4381 cgtcgcccgg tgcgttcgtg gcgtgaggtc agatagcctt ttttttccag gccgtgcagc
     4441 atcgggtaca cggtgccagc gctcatctcg tagccgtgtc ggcgtagctc ttcgatgatc
     4501 cccagcccaa agacaggttc ctcggctgca tggtgaagga tgtgcaggcg gatcaaaccg
     4561 ccgtagaggt ctttgtcagt cattttttgt gcctcacaga gcgacgctca acagccaccc
     4621 agctgcaccg ctaccgagga caaccagcca cggcgggagc ttccagaaca taagtgcgac
     4681 aagggcaact aatgccaagc cgaagtcttg cggctgaaag atggcgctag tccatacagg
     4741 ctgatacagc gcggccagca gcaagccgac tacagcggca ttgatcccgg ccagcgcagc
     4801 ttggatgcct gtattgcggc gcaaacgctc ccaaaatggc attgatccga cgaccagcaa
     4861 gaacgagggc gcgaagatag ccagcagaca cacaatgccg ccgatccagc ccgacggggc
     4921 ggtgttcatc gaggcaccaa gaaacgcggc gaacgtgaac aaagggccgg gcaccgcttg
     4981 agctgccccg taccccgcga gaaaggattc attgttgacc cagccggagg gcaccacttc
     5041 ggcttgcagt aatggcagca caacgtgacc accgccgaac accagtgatc cgacacgata
     5101 gaaggaatcc accattgcca tggtttgact tggcatcagt tcggccaaca ccggcaggcc
     5161 aatcagcaag acaaagaaca gcgagagcca aagcacgccg gcccggtgac tgaccgtgat
     5221 aggtaggggg tcatgctcaa caactttcgc tggcttgaac aataaccggc ctgcgatgcc
     5281 tgcgatagca atcacgccaa cctgtcccca cgcggacggc acaagtaaaa cgacgcaggt
     5341 agcaattgcc atgatggtga ctcgcagccc atccgtgcat aggttacgcg ccatgcccca
     5401 tactgcttga gcgaccacgg ccacagccac cacttttaag ccatgcaacg cgccctgcga
     5461 gacgtaatcg ccatagctgg agatgccgag cgcaaaaagg atcaaggcta tggcagacgg
     5521 cagcgtgaag ccagcccaag cagccagcgc cccgctgtat ccagcccgag acagtcctac
     5581 cgctatgccg acctggctgc ttgcaggccc tggcaagaac tgacaaagcg cgaccaagtc
     5641 agcatagctc cgttcggaga gccagcgccg ccgtgtgaca aattcggcgc ggaagtagcc
     5701 caagtgcgca atggggccgc caaaagatgt caatccaagc cgcagaaaaa taagaaagac
     5761 cgaccatggt ctgctgtcat cggtagggtt attcgtcata ctttcgcctt catgatctgc
     5821 aacgagttga tcaataataa gcgaaattcg ataacgaaat tcgatataaa tctagaaaaa
     5881 aatacctcta tgtgtactac gcagttttag ctgtggcttt cacaggagca cgcttactta
     5941 cggcttagcg tgctttattt tccgttttct gaggcgatcc ctaggagctc ggatctcagg
     6001 acgaaggtct ccgcgaatgt ccggtcgatc cgcgcgacgt cccaggcggg cgttcccttg
     6061 gcggacatcc acgccgcagc gtcgtgcatc agccgcacaa cctcgtcgat atcacccgag
     6121 caggcgaccc gaacgttcgg aggctcctcg ctgtccattc gctcccctgg cgcggtatga
     6181 accgccgcct catagtgcag tttgatcctg acgagcccag catgtctgcg cccaccttcg
     6241 cggaacctga ccagggtccg ctagcgggcg gccggaaggt gaatgctagg catgatctaa
     6301 ccctcggtct ctggcgtcgc gactgcgaaa tttcgcgagg gtttccgaga aggtgattgc
     6361 gcttcgcaga tctccaggcg cgtgggtgcg gacgtagtca gcgccattgc cgatcgcgtg
     6421 aagttccgcc gcaaggctcg ctggacccag atcctttaca ggaaggccaa cggtggcgcc
     6481 caagaaggat ttccgcgaca ccgagaccaa tagcggaagc cccaacgccg acttcagctt
     6541 ttgaaggttc gacagcacgt gcagcgatgt ttccggtgcg gggctcaaga aaaatcccat
     6601 ccccggatcg aggatgagcc ggtcggcagc gaccccgctc cgtcgcaagg cggaaacccg
     6661 cgcctcgaag aaccgcacaa tctcgtcgag cgcgtcttcg ggtcgaaggt gaccggtgcg
     6721 ggtggcgatg ccatcccgct gcgctgagtg cataaccacc agcctgcagt ccgcctcagc
     6781 aatatcggga tagagcgcag ggtcaggaaa tccttggata tcgttcaggt agcccacgcc
     6841 gcgcttgagc gcatagcgct gggtttccgg ttggaagctg tcgattgaaa cacggtgcat
     6901 ctgatcggac agggcgtcta agagcggcgc aatacgtctg atctcatcgg ccggcgatac
     6961 aggcctcgcg tccggatggc tggcggccgg tccgacatcc acgacgtctg atccgactcg
     7021 cagcatttcg atcgccgcgg tgacagcgcc ggcggggtct agccgccggc tctcatcgaa
     7081 gaaggagtcc tcggtgagat tcagaatgcc gaacaccgtc accatggcgt cggcctccgc
     7141 agcgacttcc acgatgggga tcgggcgagc aaaaaggcag caattatgag ccccatacct
     7201 acaaagcccc acgcatcaag cttttgccca tgaagcaacc aggcaatggc tgtaattatg
     7261 acgacgccga gtcccgacca gactgcataa gcaacaccga cagggatgga tttcagaacc
     7321 agagaaagaa aataaaatgc gatgccataa ccgattatga caacggcgga aggggcaagc
     7381 ttagtaaagc cctcggtgcg gcggacatta tccgcgaaca ggctgaacag cacggcattg
     7441 cgcgggtaac ggatgtctgg ctggaagtcg gcgcactggc ggatgttgag gagagtgcac
     7501 tgcatttctg ttttgatatc gcctgccgtg ataccgtggc gcagggctgc acactgcata
     7561 ttgatgttat cccggcacag gcatggtgct gggattgcag ccgtgaggcc gaaatcatgc
     7621 agcacgccgg atgctgtccg cactgcggca gtgaacggct gcgcatcagt gaaggtgatg
     7681 atttgcgggt aaaaagcctg gaaggtgagt gagttttacg ccgccgccgt attcagcagc
     7741 cagcgggcga attgctgcat ggccggggtt tccgtacggg actgtaaccg cgtcagccag
     7801 tagccgccga gggtgatttc tgcggcaaac ggctgtacca gtgcgcctga ctgtaacagg
     7861 cggctgaaca tacataccgg tgcgatcgct accccggcac ccagttgtgc cgcctcggcc
     7921 atggccagtg aggtatcgaa caccattacc ggctgtgacg gggaaggcgg tgtgccgccc
     7981 gcacaatcca gccagcggct ccattcatcc cggcggaatg agcgcagcag ggtaaagcgg
     8041 tgaacatcat ccggctgctg taactgttct gcaatggccg gtgagcacag cggagcgtgt
     8101 ggtgcactga aaatcagttc cgcatctgac tcatgccacg cgccgttacc gaaacggatc
     8161 gtataatcat gcccttccgc cgccgggtcc acatgattgt tatgggtgga gatatgcaga
     8221 tcaatatgcg gatggctgtc atagaatccg gccagacgcg gcagcagcca gcctgcggca
     8281 aatgttccca ccgcaccgac tttcacccgc tcacggaact gcccgtgaga aaaacactcc
     8341 agagtatccg caatccggtc aaacgcctca ttgagcaccg gcagtaatcc ctcaccttca
     8401 tgggtcagca ccagcccgcg cgagacgcgg gtaaacagca cacagccgag ttgttcttcc
     8461 agcgccctga cctgctggct gacggcggca tgggtgacat tcagctcaat cgccgcgcgg
     8521 gtaaaactga gatgacgggc ggcggcctca aaggcgcgca gcgggttaag ggggagataa
     8581 cgtctgacca taatccacct gtaagttttt ctttaggctc ttgttataaa taaccgtttg
     8641 ttctgtccgg tgaatctgac gataattgcc gccgttactc acacacggaa ggttaattct
     8701 gatgaaaaaa tcgttatctg caacactgat ttccgctctg ctggcgtttt ccgccccggg
     8761 gttttctgcc gctgataatg tcgcggcggt ggtggacagc accattaaac cgctgatggc
     8821 acagcaggat attcccggga tggcggttgc cgtctccgta aagggtaagc cctattattt
     8881 caattatggt tttgccgata ttcaggcaaa acagccggtc actgaaaata cactatttga
     8941 gctcggatct gtaagtaaaa ctttcacagg tgtgctgggt gcggtttctg tggcgaaaaa
     9001 agagatggcg ctgaatgatc cggcggcaaa ataccagccg gagctggctc tgccgcagtg
     9061 gaaggggatc acattgctgg atctggctac ctataccgca ggcggactgc cgttacaggt
     9121 gccggatgcg gtaaaaagcc gtgcggatct gctgaatttc tatcagcagt ggcagccgtc
     9181 ccggaaaccg ggcgatatgc gtctgtatgc aaacagcagt atcggcctgt ttggtgctct
     9241 gaccgcaaac gcggcgggga tgccgtatga gcagttgctg actgcacgga tcctggcacc
     9301 gctggggtta tctcacacct ttattactgt gccggaaagt gcgcaaagcc agtatgcgta
     9361 cggttataaa aacaaaaaac cggtccgcgt gtcgccggga cagcttgatg cggaatctta
     9421 cggcgtgaaa tccgcctcaa aagatatgct gcgctgggcg gaaatgaata tggagccgtc
     9481 acgggccggt aatgcggatc tggaaatggc aatgtatctc gcccagaccc gctactataa
     9541 aaccgccgcg attaaccagg ggctgggctg ggaaatgtat gactggccgc agcagaaaga
     9601 tatgatcatt aacggtgtga ccaacgaggt cgcattgcag ccgcatccgg taacagacaa
     9661 ccaggttcag ccgtataacc gtgcttcctg ggtgcataaa acgggcgcaa caactggttt
     9721 cggcgcctat gtcgccttta ttccggaaaa acaggtggcg attgtgattc tggcgaataa
     9781 aaactacccg aataccgaaa gagtcaaagc tgcacaggct attttgagtg cactggaata
     9841 atttttttcc tgaacaggcc cctgcggata cgccggggcc gtaatttaag attattcctt
     9901 atgcaataat ttgctttatg ggctgtttta tggaggatga gagtatcggg cactgacagc
     9961 ttccggctga accggatttc actgtgtgct gcggcaaact gatgtcagtc tcaacacaca
    10021 gaggaaaatg ttgtcatgga cgttctgcgt tttatcctcc gcttaccttt tattttgctg
    10081 cgtctggcgg ctcgcagtct tgtttatctc tttactctgc tgggttttct gctgcgcccg
    10141 ttcaccggac ggatccgctg ggcggtgccg ggctgggtga cctttgccgg taatcagctt
    10201 gcccggctgg agcggggggg caaccgctat ccgaaaacca tatctgcctt attattactg
    10261 actgctgcgg tggcagcggg cagttattac acctggcact ggtatcagaa caaaccgaag
    10321 ccggtggatg ttgcgccgct ggtggtgcag gatatttccg cgtctgtgca gcgcccttcg
    10381 gcggttaatt ataaccgtga tgataattca gcgcagattg tggtggtgac attctcccgc
    10441 tctgccgcac cggtaacgct gatcggtaaa ccggtcaccg ccggtattac cctgaccccc
    10501 gcaatggaag gtgagtggca gtggcgtaat gaccgtaagc tggtattcac ggcgaaaaaa
    10561 accttcccga tggggaaaac ctacaccgtc gatatggatg ccaaaacact gctggctccg
    10621 caggtggcgt taacagagaa acaaaaaacc tttaccaccc ctgagtttta ttatcgcggc
    10681 ggccgggcgg agttctatca ggatccgcaa gatccgatga aaaaacacgc cattatcggc
    10741 ctgaccttca atgcccccgc tgatgtcaaa aatctggaat cgcgtctgtc tatgacccgt
    10801 gacggcaagc cggtgccgta taccgtcact gtaatgaact gttgtcattt atgctgacgc
    10861 ccgtgccggg aggcattgat gtcccaaccc agcagctcgg cgaacaaagc tgtaatttat
    10921 tatttagcct gattgccggt gagaaaggtt tacaaaatat caccgtgggt acacaaatat
    10981 cgttagccga ctcactggta taaaaactgg ggcataacaa tgccccagtg cattttagaa
    11041 tgcgtaattc acaccgatac ctgcataatg gagtctgtcg ctttcacctt catttctatt
    11101 ggtagcgatc ccatgacaca agagactact ctgccgcaaa ttaactgggg gaatgttgac
    11161 taaatgttgc ttgcttttgt tgtttcggat atcagggttg attacctgaa tagcgtttcg
    11221 acaattttgt cgctgcccgg ctcaacaaag gttccaatac taacgccagc aacattttta
    11281 gcggacgtcg ggccacggac ttcaccgccc accctgctac cccagccggg ccatagcgca
    11341 gcgcagtcag tagcaccagc ttacctgcta ttttaatgcc cggcttaacc ctttgcccgg
    11401 cacgttgcca gcgattattc atttctaacc tcacaattgg cggaagcggc tgcgtaatgt
    11461 aaaagtatca gacgttacat aacgctccat ctcacgcaaa cgcttttcac ttgcagccag
    11521 ttcacgatcg acagcatcca atagctcacc gcttgatggc tgctgttctc cggaaaccac
    11581 gttgtctggc atcggatcca acacaaacgt cagtacgatg taggcgacaa aggtgaaaaa
    11641 ggccagacca aaaaagatgg acagcaccac caggatccgc accagtttca caggaacatc
    11701 gagataatgc gcaatacccg cgcaaacccc tttcaccatg ccctgctgcg gtatacgcca
    11761 cagtttttta ttcagattaa cgccccccat tagcggtccc tccagtttgg atgttcagca
    11821 tcaaggatgt cttccagcgc ttgaatgcgc tcacgcatcc gctgtgcgtc ctggttaagt
    11881 tctaccagac gctgttgttc actttgcgcc agctcgccgc gactggaacg attgctgtaa
    11941 tgcagccaga gccaaatcgg taagacgaac agcacaaaga tggttaacgg gatggccaga
    12001 aatagcgcgc tcatgagtac tccttacagg tgatgagcgg cggcgcgttc gggcaccgcc
    12061 agatattatt attgcttgtc ttgctgcatt ttggctttca attgcgccaa ctgctcgctg
    12121 atttcatcat ctgctttcag gtcagcaaat tgctgatcca aagacttctg cttaccgaag
    12181 ttatggcttt cagcttcagc ttccatttga tcgatacgac gctcaaaaga ttcaaagcga
    12241 gccatcgctt catccagttt gccgctgtcc agttgacgac gaacatcacg ggaagaactc
    12301 gccgcctgat ggcgcaacat caatgcctgc tgacgagcac gggtttcact gagtttgttt
    12361 tccagttcac cgatctcttt tttcatacgc gccagcgtat cgtcaaccag cgtcacctca
    12421 tgctccaggg aggcaatcag gtcagtcagt ttctgctttt cgattaacgc agaacgcgcc
    12481 aaatcttctt tttctttacg cagcgccagc tctgcttttt cctgccactc tgcctgttgg
    12541 gcgctggcct gttcaatacg acgcgataac tgtttctttt ctgccagcgc gcgtgcggag
    12601 ttggagcgca cctcaaccag cgtgtcttcc atttcctgga tcatcaaccg caccagcttc
    12661 tgcggatctt cagccttttc cagcaacgca ttaatgttgg cgttcacgat gtcggcaaaa
    12721 cgagaaaaaa tacccataat gtaatcctca cttactgttc tgatatcggg caatgccctg
    12781 ctgctgttct aatgcacttc gcatgccaac tttttaattc attgaaatat ttgaaaataa
    12841 ctaattttac ctgtcgggat aaatagggta aattggtgaa taacactaac aaatggtgaa
    12901 tttcatcatg gcaggataca aagataatct gctgggcgaa gcgaacagct ttattgaagt
    12961 gctggagcag gtttctcgtc tcgcgccgct ggataaacct gtgctggtca ttggggaacg
    13021 aggaacaggg aaagagctta tcgccaaccg cctgcactac ctctcaaccc gttggcaagg
    13081 cccgtttatt tcacttaact gcgccgcgct caacgaaaat ttacttgatt ccgaactctt
    13141 tgggcacgaa gcgggcgcct ttaccggcgc gcagaaacgt cacccaggtc ggttcgagcg
    13201 cgccgatggc ggcacactgt ttcttgatga actggcaacc gccccgatgc tggtacagga
    13261 aaaactgctg cgcgttattg agtacggaga gctggaacgc gtaggcggta gccaacctct
    13321 gcaggtcaat gtaagactgg tttgcgcaac caacgccgac ctgccacgca tggtgagtga
    13381 aggcacgttc cgcgccgacc tgctggatcg tctggccttt gacgtggtgc aacttccccc
    13441 gttacgcgaa cgtcaaagcg atatcatgtt aatggctgaa cattttgcca ttcagatgtg
    13501 ccgtgagatc gggttaccgt tgtttcctgg gttcaccgat gaggccaaag aaacgctcct
    13561 ccactaccgt tggccgggca atattcgtga actgaaaaac gtcgtggagc gttcggtata
    13621 ccgacacggg accagcgatt acccactgaa tgagattgtg attgacccgt tcaggcgtca
    13681 cgccgcaccg ccgctggcgc aagaaaccag acatacatca gtaaccctac cgctggatct
    13741 gcgtgaattc caacagcagc aggagaagga atttttgcaa accagcttac agcaggcgaa
    13801 atttaatcag aaaaaagccg ctgaattatt aggtctgacc taccatcaac tccgcgcatt
    13861 actgaagaaa caccaaattt agcgtgcagg ggcagacgtt ggacgcgaga gttaaaacag
    13921 tttaccatgt tgcaatcact gtataaaaaa acaggttaat catgatgact ctggcgttag
    13981 ttggcgaaaa aattgacaga aacaggttca ccggtgaaaa agttgaaaat agcacatttt
    14041 tcaactgtga tttttcgggt gccgacctta gcggcactga atttattggc tgccagtttt
    14101 atgatcgaga aagtcagaaa ggatgtaatt ttagtcgcgc taacctgaaa gatgccattt
    14161 tcaaaagttg tgatctctcc atggctgatt tcaggaatat caatgcgctg ggaatcgaaa
    14221 ttcgccactg ccgggcacaa gggtcagatt ttcgcggcgc aagttttatg aatatgatca
    14281 ccacccgcac ctggttttgt agcgcctata tcaccaatac caacttaagc tacgccaact
    14341 tttcaaaagt cgtactggaa aagtgcgagc tgtgggaaaa ccgctggatg ggtactcagg
    14401 tgctgggcgc aacgttcagt ggatcagacc tctctggcgg cgagttttca tccttcgact
    14461 ggcgagcagc aaacgttacg cactgtgatt tgaccaattc ggaactgggc gatttagata
    14521 tccgcggggt tgatttgcaa ggcgtcaaac tggacagcta ccaggcatcg ttgctcctgg
    14581 aacgtcttgg tatcgctgtc atgggttaat gttcagggag cggtatatgc cgccccctgc
    14641 ccttatacaa tattgtccgg gctggctttc cccctcagac gtttcgactt cgggggcata
    14701 aacgtcagag ggttccggtc cccccgtcag aacaccatac ctgaccggat gtatagctgt
    14761 tctcttcagc cgctaaagtg acatacagcg gagcaatttc taccggttgg ccagggcgac
    14821 caagcggcgc atttgcacca aatttctcaa ttttttcctg tggttggccg ccgcagcact
    14881 gcaataccgt ccagtacggc ccaggcgcga cagcatttac acggatccct ttaggggcca
    14941 gttgcttcgc cagcgattta gggcactgtt gcaaagttag cgatgaggca gccttttgtc
    15001 ttattcaaag gccttacatt tcaaaaactc tgcttaccag gcgcatttcg cccaggggat
    15061 caccataata aaatgctgat gcctggcctt tgcgtagtgc acgcatcacc tcaatacctt
    15121 tgatggtggc gtaagccgtc ttcatggatt taaatcccag cgtggcgccg attatccgtt
    15181 tcagtttgcc atgatcgcat tcaatcacgt tgttccggta cttaatctgt cggtgttcaa
    15241 cgtcagacgg gcaccggcct tcgcgtttga gcagagcaag cgcgcgacca taggcgggcg
    15301 ctttatccgt gttgatgaat cgcgggatct gccacttctt cacgttgttg aggattttac
    15361 ccagaaaccg gtatgcagct ttgctgttac gacgggagga gagataaaaa tcgacagtgc
    15421 ggccccggct gtcgacggcc cggtacagat acgcccagcg gccattgacc ttcacgtagg
    15481 tttcatccat gtgccacggg caaagatcgg aagggttacg ccagtaccag cgcagccgtt
    15541 tttccatttc aggcgcataa cgctgaaccc agcggtaaat cgtggagtga tcgacattca
    15601 ctccgcgttc agccagcatc tcctgcagct cacggtaact gatgccgtat ttgcagtacc
    15661 agcgtacggc ccacagaatg atgtcacgct gaaaatgccg gcctttgaat gggttcatgt
    15721 gcagctccat cagcaaaagg ggatgataag tttatcacca ccgactattt gcaacagtgc
    15781 ccaccgaact gaagctcacg ccgcgccgga tagcgccaag gcactacttc gcttcgagcg
    15841 acaacagtta gctccagcgg tcgccatgtt ccgccatcgc ctggcggtga tgagactttc
    15901 agcaaatcga gcattagcgc ctgccggagc gaatcgttag gtgcggcgct gacggtcacg
    15961 agcaagtcta tgtcgctgtc cggcttcagc cctccatcga tcgcagatcc gaacaggtgg
    16021 attgtgtcca gtgtcgcagc cagatggcgc tcgatcaccg cgcgagcgtg ggacagctgc
    16081 ttgaaaactt gtgcagggaa aaattcaccc atgatgccta acgttaagtt cagcggcagc
    16141 ttttaagttg cggctttgtg gaatactttt gcgcagcaaa accacaaaga cgcgacttaa
    16201 aagctgtcca aggagcgaag cgactggtgc tgcaacgcat tgttagcctt ttttccaaat
    16261 ctggtatgta taatttatat tagacataaa aaactgttca aaaaccaaat tgaaattctc
    16321 aggcattata gggaatttga tatcaccttc gacttcaacg tgaacagtag acaaatgaat
    16381 tatatctgct ttttcaataa ggctattata gatttgaccc ccgccagaga catatacatg
    16441 atctgtaact tttgatagct ctttcaaagc attttctatt gaaggaaaaa ctaggacgtt
    16501 ttcatttgag cttgaaattc cgttctttga cactactgca tatttgcgat ttggaagaac
    16561 acccatagag tcaaatgttt ttcttccgac aaggagccat tgattatatg tgagcgcttt
    16621 aaagagtagt tgctcacctt ttactgacca cgggatatca ggaccactac cgattacgcc
    16681 attttctgac actgcagaaa tcaatgatat tttcaattta actcccttaa tggctaactt
    16741 tgttttaggg cgactgccct gctgcgtaac atcgttgctg ctccataaca tcaaacatcg
    16801 acccacggcg taacgcgctt gctgcttgga tgcccgaggc atagactgta caaaaaaaca
    16861 gtcataacaa gccatgaaaa ccgccactgc gccgttacca ccgctgcgtt cggtcaaggt
    16921 tctggaccag ttgcgtgagc gcatacgcta cttgcattac agtttacgaa ccgaacaggc
    16981 ttatgtccac tgggttcgtg ccttcatccg tttccacggt gtgcgtcacc cggcaacctt
    17041 gggcagcagc gaagtcgagg catttctgtc ctggctggcg aacgagcgca aggtttcggt
    17101 ctccacgcat cgtcaggcat tggcggcctt gctgttcttc tacggcaagg tgctgtgcac
    17161 ggatctgccc tggcttcagg agatcggaag acctcggccg tcgcggtgct tgccggtggt
    17221 gctgaccccg gatgaagtgg ttcgcatcct cggttttctg gaaggcgagc atcgtttgtt
    17281 cgcccagctt ctgtatggaa cgggcatgcg gatcagtgag ggtttgcaac tgcgggtcaa
    17341 ggatctggat ttcgatcacg gcacgatcat cgtgcgggag ggcaagggct ccaaggatcg
    17401 ggccttgatg ttacccgaga gcttggcacc cagcctgcgc gagcagctgt cgcgtgcacg
    17461 ggcatggtgg ctgaaggacc aggccgaggg ccgcagcggc gttgcgcttc ccgacgccct
    17521 tgagcggaag tatccgcgcg ccgggcattc ctggcggcac tgttgcaaat agtcggtggt
    17581 gataaactta tcatcccctt ttgctgatgg agctgcacat gaacccattc aaaggccggc
    17641 attttcagcg tgacatcatt ctgtgggccg tacgctggta ctgcaaatac ggcatcagtt
    17701 accgtgagct gcaggagatg ctggctgaac gcggagtgaa tgtcgatcac tccacgattt
    17761 accgctgggt tcagcgttat gcgcctgaaa tggaaaaacg gctgcgctgg tactggcgta
    17821 acccttccga tctttgcccg tggcacatgg atgaaaccta cgtgaaggtc aatggccgct
    17881 gggcgtatct gtaccgggcc gtcgacagcc ggggccgcac tgtcgatttt tatctctcct
    17941 cccgtcgtaa cagcaaagct gcataccggt ttctgggtaa aatcctcaac aacgtgaaga
    18001 agtggcagat cccgcgattc atcaacacgg ataaagcgcc cgcctatggt cgcgcgcttg
    18061 ctctgctcaa acgcgaaggc cggtgcccgt ctgacgttga acaccgacag attaagtacc
    18121 ggaacaacgt gattgaatgc gatcatggca aactgaaacg gataatcggc gccacgctgg
    18181 gatttaaatc catgaagacg gcttacgcca ccatcaaagg tattgaggtg atgcgtgcac
    18241 tacgcaaagg ccaggcatca gcattttatt atggtgatcc cctgggcgaa atgcgcctgg
    18301 taagcagagt ttttgaaatg taaggccttt gaataagaca aaaggctgcc tcatcgctaa
    18361 ctttgcaaca gtgcc
//
