LOCUS       NZ_CP139403             9294 bp    DNA     circular CON 08-DEC-2023
DEFINITION  Klebsiella aerogenes strain C222139 plasmid pC222139-2, complete
            sequence.
ACCESSION   NZ_CP139403
VERSION     NZ_CP139403.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN38396698
            Assembly: GCF_034197895.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella aerogenes
  ORGANISM  Klebsiella aerogenes
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 9294)
  AUTHORS   Li,X.
  TITLE     Klebsiella aerogenes C222139 Genome sequencing and assembly
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9294)
  AUTHORS   Li,X.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-NOV-2023) Laboratory Medicine Center, Department of
            Clinical Laboratory, Zhejiang Provincial People's Hospital
            (Affiliated People's Hospital, Hangzhou Medical College), Shangtang
            road, Hangzhou 310014, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. v0.4.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 200.0x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 12/08/2023 13:20:06
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,253
            CDSs (total)                      :: 5,131
            Genes (coding)                    :: 5,037
            CDSs (with protein)               :: 5,037
            Genes (RNA)                       :: 122
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 87
            ncRNAs                            :: 10
            Pseudo Genes (total)              :: 94
            CDSs (without protein)            :: 94
            Pseudo Genes (ambiguous residues) :: 0 of 94
            Pseudo Genes (frameshifted)       :: 42 of 94
            Pseudo Genes (incomplete)         :: 56 of 94
            Pseudo Genes (internal stop)      :: 14 of 94
            Pseudo Genes (multiple problems)  :: 15 of 94
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP139403.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..9294
                     /organism="Klebsiella aerogenes"
                     /mol_type="genomic DNA"
                     /strain="C222139"
                     /isolation_source="sputum"
                     /host="Homo sapiens"
                     /db_xref="taxon:548"
                     /plasmid="pC222139-2"
                     /geo_loc_name="China:Hangzhou"
                     /lat_lon="29.86 N 121.56 E"
                     /collection_date="2021-07-21"
                     /collected_by="Longjie Zhou"
     gene            join(9007..9294,1..12)
                     /locus_tag="SM913_RS26215"
                     /old_locus_tag="SM913_26215"
     CDS             join(9007..9294,1..12)
                     /locus_tag="SM913_RS26215"
                     /old_locus_tag="SM913_26215"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001146176.1"
                     /GO_function="GO:0008657 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) inhibitor activity
                     [Evidence IEA]; GO:0042803 - protein homodimerization
                     activity [Evidence IEA]"
                     /GO_process="GO:0030541 - plasmid partitioning [Evidence
                     IEA]; GO:0051290 - protein heterotetramerization [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_001146176.1"
                     /translation="MPYDVEWKQGAIEDVTTLFDYIAENSSLWDAQNVTDRVLAAADKL
                     ADFPRLYEVDSRYGEDVRRISLMGQHVLYDVDDQTRKVRVLAVVGQRQNPHIVL"
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            complement(74..451)
                     /locus_tag="SM913_RS26220"
                     /old_locus_tag="SM913_26220"
     CDS             complement(74..451)
                     /locus_tag="SM913_RS26220"
                     /old_locus_tag="SM913_26220"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000312627.1"
                     /translation="MAWVTVRQATELTGKARSSLYRDMAKGRVSYRTEADGGRVVDTSE
                     LIRVYGELRQDETHERDELRLSGETEKMASDALIAEIKALREEVAGLRQEMQSMRLLEH
                     KPETAETPAGTPRRWWPWGKR"
                     /name="hypothetical protein"
     gene            520..699
                     /locus_tag="SM913_RS26225"
                     /old_locus_tag="SM913_26225"
     CDS             520..699
                     /locus_tag="SM913_RS26225"
                     /old_locus_tag="SM913_26225"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rop family plasmid primer RNA-binding protein"
                     /protein_id="WP_000165971.1"
                     /translation="MTKQEKTALNMAKFIKEQSLLLLDKLNELDMDTPADMCERLHEDA
                     ETLWQVMRDKLGEE"
                     /name="Rop family plasmid primer RNA-binding protein"
     gene            complement(727..1257)
                     /locus_tag="SM913_RS26230"
                     /old_locus_tag="SM913_26230"
     CDS             complement(727..1257)
                     /locus_tag="SM913_RS26230"
                     /old_locus_tag="SM913_26230"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_004153058.1"
                     /translation="MALYMVFIEDAEDRNGERCIMPTSEHLEDMVVLAWQTGAYVFCFV
                     DRAQHLAMMKSIGMYDERLNSDEKATYFFTGKNPQWERNKPTGMKLCDYLYRKVERFAI
                     ENGVQVVDAGKCSPEQINAMIDVVSERHGESAVNEKLKAELMREYNSRYFNVPVPELPE
                     DKPARRWWPFGKK"
                     /name="hypothetical protein"
     gene            complement(1264..1995)
                     /locus_tag="SM913_RS26235"
                     /old_locus_tag="SM913_26235"
     CDS             complement(1264..1995)
                     /locus_tag="SM913_RS26235"
                     /old_locus_tag="SM913_26235"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobC family replication-relaxation protein"
                     /protein_id="WP_004152551.1"
                     /translation="MALELYNVSHAKRQARNAEKTRLTLRWLREELCSTAELVARRLGI
                     AAVQPVYRFLDSLVAKGLLVRTKYPVDGRQVSVWGLTPHGVAFSFDEDEPLADVIPFQP
                     SRVSAAHLPHRLAVQSLRLDMEARGATGWRILHRLSLKGMKVPDALAELDGKTVAFEVE
                     RTVKSRRRYQEVVSGYLFNRKANGIDEIWYICPDRATQVRVQRAILSVDEIVNPQTGEA
                     RKTAELDRERLFACFKFMTTE"
                     /name="MobC family replication-relaxation protein"
     gene            complement(1995..3959)
                     /locus_tag="SM913_RS26240"
                     /old_locus_tag="SM913_26240"
     CDS             complement(1995..3959)
                     /locus_tag="SM913_RS26240"
                     /old_locus_tag="SM913_26240"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004178196.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TraM recognition domain-containing protein"
                     /protein_id="WP_004178196.1"
                     /translation="MFNTDSLAWKWHIPELARQIYPWVSWLYQEYYGLAGAFLVIGLFF
                     GLAELWAGRMRFVGLSHKERREYADRYKRDNKRPAPFSVLASLDSPGRMVRARRHVWNY
                     AYWLTGAAGLALLGGLVVAVFIESWGETVLRPDLYANADYYLLQPANLFGIAWCAGGLA
                     VGIVLARLLAFLLLDGHFAAADEAVNAKLNQESRRSSQRTGEMTDVRHLHFGEPVPVNA
                     LADFSSEQARQEQAVFLGKDEQGKPVLVPRDTWRKTNIQILGLPGSGKSVMATNALIRC
                     VRDFGDAVVYFDPKGDAWAPHVFRAHCPDFTLLDLRPGKPAQLNLFRDLDQYALKNLLI
                     AGLNLGETGDVADHYRISEQKAAKLIAEQFPQGANIQQVLAAAYALPEALKKDVKGLIT
                     RLENVADLSVLQTDSGIDVAGIINGGGCLYVIGSMDDEAVIRVQKMLFARCAQIIIARD
                     EFREWPHVSVMLDEIKYLLSKYVLNALGTLRSRDCNLLLAHQSLGDFGQCGQDLPAEFV
                     KTTVLDNTPIRWFYRAASLESAQWAAGQTGEIRVDVERRRASREAGNVEHISGDSFIQK
                     EARPLFDVNTLQHLPDGFAVMTGLGVARMAFSSPLRVERREIPLQRFPVLAKTDPLAEF
                     RPPADGGGPKADDDFAGIY"
                     /name="TraM recognition domain-containing protein"
     gene            complement(5440..5589)
                     /locus_tag="SM913_RS26245"
                     /old_locus_tag="SM913_26245"
     CDS             complement(5440..5589)
                     /locus_tag="SM913_RS26245"
                     /old_locus_tag="SM913_26245"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891188.1"
                     /GO_component="GO:0019867 - outer membrane [Evidence IEA]"
                     /GO_process="GO:0019835 - cytolysis [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin release lysis protein"
                     /protein_id="WP_004152552.1"
                     /translation="MKKVKVVFLFILIFSGFLLVACQANYIRDVQGGTVAPSSSSELTG
                     IAVQ"
                     /name="colicin release lysis protein"
     gene            complement(5674..5931)
                     /locus_tag="SM913_RS26250"
                     /old_locus_tag="SM913_26250"
     CDS             complement(5674..5931)
                     /locus_tag="SM913_RS26250"
                     /old_locus_tag="SM913_26250"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin immunity family protein"
                     /protein_id="WP_004152553.1"
                     /translation="MGLKLHIHWFDKKTEEFKGGEYSKDFGDDGSVIESLGMPLKDNIN
                     NGWFDVEKSWVSILQPHFKNVIDISKFDYFVSFVYRDGNW"
                     /name="cloacin immunity family protein"
     gene            complement(5941..7626)
                     /locus_tag="SM913_RS26255"
                     /old_locus_tag="SM913_26255"
     CDS             complement(5941..7626)
                     /locus_tag="SM913_RS26255"
                     /old_locus_tag="SM913_26255"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin-like bacteriocin tRNase domain-containing
                     protein"
                     /protein_id="WP_004178188.1"
                     /translation="MSGGDGRGPGNSGLGHNGGQASGNVNGTSGKGGPSSGGGTDPNSG
                     PGWGTTHTPNGDIHNYNPGEFGNGGSKPGGNGGNSGNHSGSSGGGQSSATAMAFGLPAL
                     ATPGAEGLALSVSGDALSAAVADVLAALKGPFKFGLWGIAIYGVLPSEIAKDDPKMMSK
                     IVTSLPADTVTETPVSSLPLDQATVSVTKRVADIVKDERQHIAVVTGRPMSVPVVDAKP
                     TKRPGVFSVSIPGLPSLQVSVPKGVPAAKAPPKGIIAEKGDSRPAGFTAGGNSREAVIR
                     FPKESGQKPVYVSVTDVLTPAQVKQRLEEEKRRQQAWDAAHPEEGLKREYDKAKAELDA
                     EDKNIATLNSRIASTEKAIPGARAAVQEADKKVKEAEANKDDFVTYNPPHEYGSGWQDQ
                     VRYLDKDIQNQNEKLKAAQTSLNEMNESLSRDKAALSGAMESRKQKEKKAKDAENKLNE
                     EKKKPRKGTKDYGHDYFPDPKTEDIKGLGELKEGKPKTPKQGGGGKRARWYGDKKRKIY
                     EWDSQHGELEGYRASDGEHLGAFDPKTGKQVKGPDPKRNIKKYL"
                     /name="colicin-like bacteriocin tRNase domain-containing
                     protein"
     gene            8029..8448
                     /locus_tag="SM913_RS26260"
                     /old_locus_tag="SM913_26260"
     CDS             8029..8448
                     /locus_tag="SM913_RS26260"
                     /old_locus_tag="SM913_26260"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016247941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Exc2 family lipoprotein"
                     /protein_id="WP_001254601.1"
                     /translation="MRRSGSKLCLIAMITATATLTACAPKGSVEQHTRHYVYASDDGFD
                     PNFSTQKADTTRMMVPFFRQFWDMGAKDKATGKSRSDVQQRIQQFHSQEFLNSLQGTTQ
                     FAGTDYRSKDLTPKKSRLLADTISAVYLDGYEGRQ"
                     /name="Exc2 family lipoprotein"
     gene            8754..9017
                     /locus_tag="SM913_RS26265"
                     /old_locus_tag="SM913_26265"
     CDS             8754..9017
                     /locus_tag="SM913_RS26265"
                     /old_locus_tag="SM913_26265"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000072676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000072676.1"
                     /translation="MSNTTHYENANFLRELAESLPRILPEGGPDKAALLQRLANEELAQ
                     AEYEDQVRAKVTAARADTRPGMTTEQLRQRLHGRYQELRDAV"
                     /name="hypothetical protein"
     BGC             941..9294
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          4759..5337
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="95.361"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(1268..1995)
                     /name="MOBC"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="1.32e-150"
ORIGIN
        1 attgttctct aataaccggt gacggggacg caattcattg cgtggccgtc gccggttgga
       61 caagcacagc gcgtcagcgt tttccccacg gccaccaccg gcgcggtgtt ccggccgggg
      121 tctctgctgt ctccggtttg tgttccagca gtctcatgga ctgcatttcc tgccgtagcc
      181 cggccacctc ctccctgagt gcttttatct ccgcgatcaa cgcgtcggag gccatttttt
      241 cagtctcacc cgacagtctc aactcgtccc gctcgtgagt ctcatcctgt cttaactcac
      301 cgtacacccg gataagctcg ctggtatcca ccacccggcc gccatcagct tccgtacggt
      361 atgatacgcg gcctttcgcc atatcccgat acagggaact tcgggcttta cccgtcagtt
      421 ccgtcgcctg tctcaccgtc acccacgcca ttgtctcacc ccgctatttt tgagacagta
      481 tacctgacag gcgcacacca tgcccggaag gaaagaatca tgacaaaaca ggaaaaaaca
      541 gccctcaata tggctaaatt tattaaggag cagtcgctgc tattgctcga taaactgaat
      601 gagctggata tggatacccc ggccgacatg tgcgagcggc tacacgagga tgcggaaaca
      661 ctctggcagg tgatgcggga taagctcggg gaggaataac agcaccggca tggccggtgc
      721 tggcatttat tttttgccga acggccacca ccggcgggca ggtttgtcct ccggcagttc
      781 aggtaccggc acgttaaaat agcggctgtt atattcccgc atcagctccg ctttcagctt
      841 ctcgttcacc gcgctttccc cgtgccgctc actcaccacg tcaatcatcg cgttaatctg
      901 ctccggtgag cacttcccgg catcaaccac ctgcacaccg ttctcgatgg cgaaccgctc
      961 caccttgcga tagaggtaat cacacagctt cattcctgtg ggtttgttcc gttcccattg
     1021 cggattttta ccagtgaaaa agtacgtggc tttttcgtcg ctgttgagcc gctcgtcata
     1081 catcccgatg gatttcatca tcgccagatg ctgggcccgg tcgacaaaac agaaaacata
     1141 cgccccggtc tgccaggcga gcaccaccat atcttccaga tgctcgctgg tcggcatgat
     1201 gcagcgctcg ccgttccggt cctccgcgtc ttcaataaat accatgtaca gcgccataat
     1261 ccctcactcc gttgtcataa atttaaagca cgcaaacaac cgttcacgat ccagctctgc
     1321 cgttttgcgg gcctcgccgg tctgtgggtt cacgatttca tccaccgaca ggattgcccg
     1381 ctgcaccctg acctgcgtcg cccggtccgg gcagatgtac cagatttcat cgatgccgtt
     1441 agctttgcgg ttgaacagat acccggacac cacttcctga taccggcgac ggctcttgac
     1501 ggtgcgctcc acctcaaacg ccaccgtttt accgtccagc tccgccaggg cgtccggcac
     1561 tttcatgcct ttaagactca gacggtgcag aatgcgccag ccggtggccc ctctggcttc
     1621 catatcaagg cgcagggatt gcacggccag ccggtgcggc agatgtgctg ccgacaccct
     1681 tgacggctga aacggaataa catccgccag cggttcgtcc tcgtcgaacg agaacgccac
     1741 gccatgcggc gtcagccccc acacgctgac ctgacggccg tccaccggat atttggtccg
     1801 gaccagcagc cctttcgcca ccaggctgtc gaggaagcgg tagaccggct gcaccgccgc
     1861 aatccccagc cgccgcgcaa ccagctccgc cgtggaacac agctcttccc gcaaccagcg
     1921 cagggtcagc cgggttttct ccgcgttccg cgcctgtcgt ttcgcgtggc tgacgttgta
     1981 cagctccagc gccatcagta aatccccgca aaatcatcat ccgctttcgg cccgccgccg
     2041 tcggccgggg gccggaactc cgccagggga tcggttttcg ccagcaccgg gaaacgctgc
     2101 aacgggattt cccggcgctc aacccgcagc ggactgctga acgccatccg ggccacaccc
     2161 agcccggtca tgaccgcgaa cccgtccggc aggtgttgca gggtgttcac gtcaaacagc
     2221 ggccgcgcct ccttctggat gaagctgtcc ccgctgatat gctccacgtt ccccgcctcc
     2281 cggctggcac ggcggcgctc cacgtccacc ctgatttccc cggtctgccc cgccgcccac
     2341 tgcgcggact ccaggctggc cgcccggtaa aaccagcgga tcggcgtgtt atccagtacc
     2401 gtggttttca caaattcagc gggcagatcc tgcccgcact gcccgaaatc gcccagcgac
     2461 tggtgcgcga gcaacagatt gcagtcccgg ctgcgcagcg tccccagtgc gttcagtaca
     2521 tacttcgaca gcagatattt aatttcatcg agcatcacgc tgacgtgtgg ccactcccgg
     2581 aactcgtccc gcgcaatgat gatttgcgcg cagcgggcaa acagcatttt ttgcacacgg
     2641 atcaccgcct cgtcgtccat cgagccgata acgtacaggc agccgccgcc gttgataatc
     2701 cccgccacat cgatgccact gtccgtctgc aggacgctca ggtcagcgac gttttccagc
     2761 ctagtgatca accccttcac gtcctttttc agggcctccg gcagcgcgta cgccgccgcc
     2821 agcacctgct gaatgtttgc cccctgcgga aactgctccg caatcagctt cgccgctttc
     2881 tgctcgctga tgcggtagtg gtccgccacg tcgccggtct cgcccaggtt aagcccggca
     2941 atcagcaggt ttttcagcgc gtactggtcg agatcgcgga acagattcag ctgcgccggt
     3001 ttccccggcc gcagatccag cagggtgaag tccggacagt gcgcccggaa gacgtgcggc
     3061 gcccatgcgt cccctttggg gtcgaagtac accaccgcgt ccccgaaatc gcgtacgcag
     3121 cgaatgagcg cgttggtggc catcacgctc ttgccgctcc cgggcaggcc gaggatctga
     3181 atgttggtct tgcgccaggt atcacgcgga accagcaccg gcttgccctg ctcatcctta
     3241 cccagaaaca ccgcctgctc ctgccgggcc tgctccgagg aaaaatcggc cagcgcatta
     3301 accggtaccg gctccccgaa atgcaggtgg cgcacgtcgg tcatctctcc tgtccgctgg
     3361 ctgctgcgcc ggctctcctg attcagtttc gcgttcaccg cctcgtcagc agccgcaaaa
     3421 tgaccgtcaa gcagcaggaa cgccagcagc cgcgccaaca caatcccgac agccagcccg
     3481 cccgcgcacc aggcaatccc gaacaggtta gccggctgca gcaggtaata atctgcgttt
     3541 gcgtagaggt ccggacgcag gacggtttct ccccagctct cgataaacac ggcgacaacc
     3601 agccccccca gaagggccag accggccgcg ccggtcagcc agtacgcgta gttccagaca
     3661 tgtcgacgtg ccctgaccat ccgcccgggc gaatccagcg aggccagcac cgaaaatggc
     3721 gctggccgtt tattatcgcg cttatagcga tcggcatact cccgtcgctc cttatgactc
     3781 agccccacaa aacgcatccg tccggcccaa agttcagcca gaccgaaaaa caggccgata
     3841 actaggaaag ccccggccag accgtaatac tcctggtaca gccagctgac ccacggataa
     3901 atctgccggg ccagctccgg aatgtgccac ttccaggcaa gcgaatccgt attaaacatg
     3961 ttctctctcc ttcagacgat ggtttgccgg cgtgatgtgc agcccccgct gcacaagccg
     4021 cggacatgcc ccaaggcatg gcggcggcgg tcacgtccgt ggtgattgcg ttcagctttc
     4081 accacggagg ccagcctctt tccgccccat gcggaaaagg cgcagccccg gaggaacaac
     4141 gagcacgccc cagcgtgtga gaggaaaagg cggcacccca gtgcggtctt ttccggtgtt
     4201 ccggcccccg tcagagttcg ccatagcgag cggctgacca cccgcaaaat caggagcagc
     4261 tttgctgctt cgccaggtgc gtccagcacc gtggattttt gtgggtggtc aggcgtgagc
     4321 ctgacggggg ccgggtgaat ttctggcgtg gccggcgtcc agccggacgg agccagaaag
     4381 agggggagag accgtgcgtc ggtggcgtcc agccagcgta agcaggggat atccccctga
     4441 ggtcagccac gccctcgcgg ggatgacctg tatttctccg taaggagaaa aaagcaacag
     4501 agataggtta acgtaaaatg ttcagcgaaa aaccgatatg attcacctat cctggtaatt
     4561 tattatcagg gaatataaag acttaatcag gggacaatat gccacatcag cgcgtccggt
     4621 gtccgtcttg taggtgccgg ggaaattgcg cctcctcgct cactcggtcg ctacgctccg
     4681 gccgtgagac tgcggcgggc gctgcggaca catgcaaagt tacccacaga ttccgtgaat
     4741 aagcagggga ctaacatgtg aggcaaaacg gcaaggccac gcaggtggcg tttttccata
     4801 ggctccgccc tcctgactga gttcacataa acagacgctt tttcggtgca tctgtgggag
     4861 ccggtggctc aaccatgaat cagtcaggag tggcgaaacc cgacaggact taaagatcat
     4921 caccgtttcc gatgaatcgc tccctcttgc gctctcctgt tccaaccctg ccgtttcccg
     4981 gatacctgtt ccgcctttct cccttgcggg aagtgtggcg ctttctcata gctcacactc
     5041 tggtatctcg gctcggtgta ggtcgttcgc tccaagctgg gctgtaagca agaacccccc
     5101 gttcagcccg actgctgcgc cttatccggt aactgttcac ttgagtccaa cccggaaaag
     5161 cacgcaaaac gccactggca gcagccattg gtaactggga gttcgcagag gatttgttta
     5221 gctaaacacg cggttgctct tgaagtgtgc gccaaagtcc ggctacactg gaaggacaga
     5281 tttggttgct gtgctctgcg aaagccagtt accacggtta agcagttccc caactgactt
     5341 aaccttcgat caaaccacct ccccaggtgg ttttttcgtt tacagggcaa aagattacgc
     5401 gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc tactgaaccg cgatccccgt
     5461 cagttcagag gaggacgatg gtgccaccgt tccaccctga acatcccgga tatagtttgc
     5521 ctgacatgcg accagaagaa agcctgaaaa aatcaatata aaaagaaaaa caacctttac
     5581 ctttttcata taccttccct gtatttaaaa accccggtat tcatccctga acaccggaag
     5641 tctgtatttc aaatcatcct tgataacttt tgcttaccag ttaccatccc ggtaaacaaa
     5701 ggatacaaag taatcaaatt tactaatatc gattacattt ttaaagtgtg gctgtaatat
     5761 cgaaacccat gatttttcaa catcaaacca accattatta atattatcct ttaaaggcat
     5821 ccccagactt tcaatgacag aaccatcatc accgaagtct tttgagtatt caccaccttt
     5881 aaactcttcg gttttcttat caaaccaatg aatatgtaat ttaagcccca tatttacctc
     5941 ttaaagatat tttttaatgt ttcgttttgg atccggccct ttaacctgct tacccgtttt
     6001 tggatcgaat gccccgaggt gttcgccatc actggcgcgg tacccttcaa gctcaccgtg
     6061 ctgggaatcc cattcataaa ttttacgctt tttatcacca taccatcggg cccgcttacc
     6121 accaccacct tgtttagggg ttttaggttt accctctttc aactctccca accccttaat
     6181 atcttcagtc ttgggatcag gaaaataatc atggccgtaa tctttagttc ccttacgagg
     6241 ttttttcttt tcctcattta atttattttc tgcatccttc gcttttttct ccttttgttt
     6301 ccggctctcc atcgccccgg aaagcgcagc cttatccctg gataaggatt cattcatttc
     6361 gtttaaagat gtctgggcag cttttaattt ctcattctga ttctgaatat ccttatcaag
     6421 atagcgaacc tgatcctgcc acccggagcc atattcatga ggcgggttat aagtcacaaa
     6481 atcatcttta tttgcctctg cctcttttac ctttttatcg gcttcctgaa cagcagccct
     6541 tgcaccgggg atcgccttct ctgtcgatgc aatgcgactg tttaaggtcg caatattttt
     6601 atcttcagca tccagctcag ctttcgcttt atcatactct cttttcagcc cctcttccgg
     6661 gtgagcagcg tcccatgcct gctggcgacg cttttcttcc tccagacgct gttttacctg
     6721 tgccggagta agaacatccg tcaccgacac atagaccggt ttctgtccgc tctctttcgg
     6781 gaaacgaata acggcttcac gggagttacc accggccgta aaaccagccg gacgtgaatc
     6841 acctttttca gcaataatgc cttttggcgg ggctttcgcg gccggaacac ctttaggtac
     6901 gctcacctgc agagacggga gacccggaat cgacacactg aatacccccg gacgttttgt
     6961 cggtttcgca tccaccacag gaacactcat tggccggccg gtgacaaccg caatatgctg
     7021 ccgctcgtcc ttcacaatat ccgccacacg tttagtgacg ctgaccgtcg cctggtccag
     7081 cggcagggag ctgaccggcg tctccgttac cgtgtctgcc ggcaatgacg tcacgatttt
     7141 tgacatcatt ttcggatcat cttttgctat ctcagaaggc agcactccgt aaatcgcaat
     7201 cccccacaga ccaaacttaa acggaccttt cagggcagcc agcacatcag caacagcggc
     7261 cgacaacgca tcgccggaaa cggataaagc cagtccttca gcccccggag tggccaaggc
     7321 aggcagaccg aaggccatcg cggtggccga agactgtccg ccaccagagc tcccgctatg
     7381 attgccgctg ttaccgccat taccaccggg tttactcccg ccgttaccaa actcccccgg
     7441 gttatagtta tgaatatccc cgttaggtgt atgcgtcgta ccccagcccg gcccgctgtt
     7501 tggatccgta ccaccacctg atgaagggcc acctttacct gatgtaccgt tcacattccc
     7561 actggcctga ccaccattgt gtcccagacc tgaattaccc ggacctcgtc cgtctccgcc
     7621 actcatatac ttttcctctt tgacttttaa aacaataaac taaaataaaa tactgtacat
     7681 ataaccactg gttttatata cagtataaaa attacgctgc cttgtttttc atgtcaagtc
     7741 tgtaaatttg cgtttttgtg aaaatgatca aaaaaacagc cactcacacc atgcgcaatc
     7801 ccccccagat gcaacaaaaa ccagcacaaa cggcgccgtt ctccggcctc agtatgtttt
     7861 actgaaatca ttatatgaga taccagaaag ccccctccgg gacaggaaaa gaaacggggg
     7921 gtctggttcg ggttgttcgg tcactgaaca cggtcagaaa ctgatgataa gatagcctgc
     7981 ggatatataa ctcaatgaga aaaaagaatt aaaggtaagg agacgctcat gagacgttcc
     8041 ggcagcaaac tgtgtcttat cgccatgata acagcgacag caactctcac tgcctgtgct
     8101 ccaaagggca gcgtggaaca gcatacccgg cattacgtat atgcttcaga tgacggtttt
     8161 gatcccaatt tttccaccca gaaagctgac acaacacgaa tgatggtgcc ttttttccgg
     8221 cagttctggg atatgggcgc aaaggataaa gcgaccggaa aatcacggag tgatgtgcag
     8281 caacgcattc agcagtttca cagtcaggaa tttttaaact cactccaagg cacaacacaa
     8341 tttgcgggta ccgattaccg cagcaaagac ctcacaccga aaaaatcaag gctactggct
     8401 gacaccattt cagctgttta tctcgatggc tatgaaggca gacagtaagt ggatttacca
     8461 taacgcgtca ttacgcgcac cgctcagacg ggctcagggc gtttccggcg gctacgggat
     8521 aaaacaggca acaacccccc cggaaaactg ccggaaacgc gcccgataaa ttttatccta
     8581 atgcatgcct atgcacgcaa ctgcatggca tatgttttga cgtaaaatgg atgccgtaag
     8641 ccctttttta ccgactttct gcttcatcag cctgactgac acgaccatat tctttcagac
     8701 cgccccctgc taaacttcct tcatattgcc gcattaaccc gggaggctcc gcaatgagca
     8761 acactacaca ctacgaaaac gccaactttc ttcgggaact ggctgaaagc ctgccccgca
     8821 tactgccgga aggtggcccg gacaaagctg cgctgttgca gcgactggct aacgaagaac
     8881 tggcccaggc agagtatgaa gatcaggttc gcgccaaagt gaccgccgcc cgtgctgaca
     8941 cgcgtccggg tatgaccacg gaacaactcc gccagcgcct gcatggccgt tatcaggaac
     9001 tgcgcgatgc cgtatgacgt ggaatggaag cagggagcca tcgaggatgt aacgacgctg
     9061 tttgactata tcgcggaaaa ttcatccctg tgggatgcgc agaacgttac cgaccgggtt
     9121 ctcgctgcgg cggacaaact ggccgacttc ccgcgactct atgaagtgga ctcacgctat
     9181 ggcgaggacg ttcgccggat cagtctgatg ggacagcatg tcctctatga tgttgatgac
     9241 cagaccagaa aagtccgggt tctggccgtg gtcggccagc gccagaatcc ccat
//
