LOCUS       NZ_CP137429            18588 bp    DNA     circular CON 26-JAN-2024
DEFINITION  Klebsiella pneumoniae strain KP88_L3_06.23_ST147_NDM14 plasmid
            unnamed1, complete sequence.
ACCESSION   NZ_CP137429
VERSION     NZ_CP137429.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN37951969
            Assembly: GCF_033242065.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 18588)
  AUTHORS   Turton,J.F. and Turton,J.A.
  TITLE     Klebsiella pneumoniae ST147 - the rise of a multiresistant and
            hypervirulent type
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 18588)
  AUTHORS   Turton,J.F. and Turton,J.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-OCT-2023) HCAI, Fungal, AMR, AMU & Sepsis Division,
            United Kingdom Health Security Agency, 61 Colindale Avenue, London,
            London NW9 5EQ, United Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: flye v. 2.9.1-b1780
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 63x
            Sequencing Technology             :: Oxford Nanopore GridION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/24/2024 10:55:54
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,848
            CDSs (total)                      :: 5,725
            Genes (coding)                    :: 5,525
            CDSs (with protein)               :: 5,525
            Genes (RNA)                       :: 123
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 87
            ncRNAs                            :: 11
            Pseudo Genes (total)              :: 200
            CDSs (without protein)            :: 200
            Pseudo Genes (ambiguous residues) :: 0 of 200
            Pseudo Genes (frameshifted)       :: 110 of 200
            Pseudo Genes (incomplete)         :: 97 of 200
            Pseudo Genes (internal stop)      :: 27 of 200
            Pseudo Genes (multiple problems)  :: 29 of 200
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP137429.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..18588
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="KP88_L3_06.23_ST147_NDM14"
                     /isolation_source="rectal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:573"
                     /plasmid="unnamed1"
                     /geo_loc_name="United Kingdom: England"
                     /collection_date="2023-01"
                     /genotype="ST147"
     gene            complement(join(18432..18588,1..262))
                     /locus_tag="R5O57_RS29110"
                     /old_locus_tag="R5O57_29110"
                     /pseudo=""
     CDS             complement(join(18432..18588,1..262))
                     /locus_tag="R5O57_RS29110"
                     /old_locus_tag="R5O57_29110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016247941.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="Exc2 family lipoprotein"
                     /name="Exc2 family lipoprotein"
     gene            665..2350
                     /locus_tag="R5O57_RS29115"
                     /old_locus_tag="R5O57_29115"
     CDS             665..2350
                     /locus_tag="R5O57_RS29115"
                     /old_locus_tag="R5O57_29115"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin-like bacteriocin tRNase domain-containing
                     protein"
                     /protein_id="WP_004178188.1"
                     /translation="MSGGDGRGPGNSGLGHNGGQASGNVNGTSGKGGPSSGGGTDPNSG
                     PGWGTTHTPNGDIHNYNPGEFGNGGSKPGGNGGNSGNHSGSSGGGQSSATAMAFGLPAL
                     ATPGAEGLALSVSGDALSAAVADVLAALKGPFKFGLWGIAIYGVLPSEIAKDDPKMMSK
                     IVTSLPADTVTETPVSSLPLDQATVSVTKRVADIVKDERQHIAVVTGRPMSVPVVDAKP
                     TKRPGVFSVSIPGLPSLQVSVPKGVPAAKAPPKGIIAEKGDSRPAGFTAGGNSREAVIR
                     FPKESGQKPVYVSVTDVLTPAQVKQRLEEEKRRQQAWDAAHPEEGLKREYDKAKAELDA
                     EDKNIATLNSRIASTEKAIPGARAAVQEADKKVKEAEANKDDFVTYNPPHEYGSGWQDQ
                     VRYLDKDIQNQNEKLKAAQTSLNEMNESLSRDKAALSGAMESRKQKEKKAKDAENKLNE
                     EKKKPRKGTKDYGHDYFPDPKTEDIKGLGELKEGKPKTPKQGGGGKRARWYGDKKRKIY
                     EWDSQHGELEGYRASDGEHLGAFDPKTGKQVKGPDPKRNIKKYL"
                     /name="colicin-like bacteriocin tRNase domain-containing
                     protein"
     gene            2360..2617
                     /locus_tag="R5O57_RS29120"
                     /old_locus_tag="R5O57_29120"
     CDS             2360..2617
                     /locus_tag="R5O57_RS29120"
                     /old_locus_tag="R5O57_29120"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin immunity family protein"
                     /protein_id="WP_004152553.1"
                     /translation="MGLKLHIHWFDKKTEEFKGGEYSKDFGDDGSVIESLGMPLKDNIN
                     NGWFDVEKSWVSILQPHFKNVIDISKFDYFVSFVYRDGNW"
                     /name="cloacin immunity family protein"
     gene            2702..2851
                     /locus_tag="R5O57_RS29125"
                     /old_locus_tag="R5O57_29125"
     CDS             2702..2851
                     /locus_tag="R5O57_RS29125"
                     /old_locus_tag="R5O57_29125"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891188.1"
                     /GO_component="GO:0019867 - outer membrane [Evidence IEA]"
                     /GO_process="GO:0019835 - cytolysis [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin release lysis protein"
                     /protein_id="WP_004152552.1"
                     /translation="MKKVKVVFLFILIFSGFLLVACQANYIRDVQGGTVAPSSSSELTG
                     IAVQ"
                     /name="colicin release lysis protein"
     gene            4332..6296
                     /locus_tag="R5O57_RS29130"
                     /old_locus_tag="R5O57_29130"
     CDS             4332..6296
                     /locus_tag="R5O57_RS29130"
                     /old_locus_tag="R5O57_29130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004178196.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TraM recognition domain-containing protein"
                     /protein_id="WP_004178196.1"
                     /translation="MFNTDSLAWKWHIPELARQIYPWVSWLYQEYYGLAGAFLVIGLFF
                     GLAELWAGRMRFVGLSHKERREYADRYKRDNKRPAPFSVLASLDSPGRMVRARRHVWNY
                     AYWLTGAAGLALLGGLVVAVFIESWGETVLRPDLYANADYYLLQPANLFGIAWCAGGLA
                     VGIVLARLLAFLLLDGHFAAADEAVNAKLNQESRRSSQRTGEMTDVRHLHFGEPVPVNA
                     LADFSSEQARQEQAVFLGKDEQGKPVLVPRDTWRKTNIQILGLPGSGKSVMATNALIRC
                     VRDFGDAVVYFDPKGDAWAPHVFRAHCPDFTLLDLRPGKPAQLNLFRDLDQYALKNLLI
                     AGLNLGETGDVADHYRISEQKAAKLIAEQFPQGANIQQVLAAAYALPEALKKDVKGLIT
                     RLENVADLSVLQTDSGIDVAGIINGGGCLYVIGSMDDEAVIRVQKMLFARCAQIIIARD
                     EFREWPHVSVMLDEIKYLLSKYVLNALGTLRSRDCNLLLAHQSLGDFGQCGQDLPAEFV
                     KTTVLDNTPIRWFYRAASLESAQWAAGQTGEIRVDVERRRASREAGNVEHISGDSFIQK
                     EARPLFDVNTLQHLPDGFAVMTGLGVARMAFSSPLRVERREIPLQRFPVLAKTDPLAEF
                     RPPADGGGPKADDDFAGIY"
                     /name="TraM recognition domain-containing protein"
     gene            6296..7027
                     /locus_tag="R5O57_RS29135"
                     /old_locus_tag="R5O57_29135"
     CDS             6296..7027
                     /locus_tag="R5O57_RS29135"
                     /old_locus_tag="R5O57_29135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobC family replication-relaxation protein"
                     /protein_id="WP_004152551.1"
                     /translation="MALELYNVSHAKRQARNAEKTRLTLRWLREELCSTAELVARRLGI
                     AAVQPVYRFLDSLVAKGLLVRTKYPVDGRQVSVWGLTPHGVAFSFDEDEPLADVIPFQP
                     SRVSAAHLPHRLAVQSLRLDMEARGATGWRILHRLSLKGMKVPDALAELDGKTVAFEVE
                     RTVKSRRRYQEVVSGYLFNRKANGIDEIWYICPDRATQVRVQRAILSVDEIVNPQTGEA
                     RKTAELDRERLFACFKFMTTE"
                     /name="MobC family replication-relaxation protein"
     gene            7034..7564
                     /locus_tag="R5O57_RS29140"
                     /old_locus_tag="R5O57_29140"
     CDS             7034..7564
                     /locus_tag="R5O57_RS29140"
                     /old_locus_tag="R5O57_29140"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_004153058.1"
                     /translation="MALYMVFIEDAEDRNGERCIMPTSEHLEDMVVLAWQTGAYVFCFV
                     DRAQHLAMMKSIGMYDERLNSDEKATYFFTGKNPQWERNKPTGMKLCDYLYRKVERFAI
                     ENGVQVVDAGKCSPEQINAMIDVVSERHGESAVNEKLKAELMREYNSRYFNVPVPELPE
                     DKPARRWWPFGKK"
                     /name="hypothetical protein"
     gene            complement(7592..7771)
                     /locus_tag="R5O57_RS29145"
                     /old_locus_tag="R5O57_29145"
     CDS             complement(7592..7771)
                     /locus_tag="R5O57_RS29145"
                     /old_locus_tag="R5O57_29145"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rop family plasmid primer RNA-binding protein"
                     /protein_id="WP_000165971.1"
                     /translation="MTKQEKTALNMAKFIKEQSLLLLDKLNELDMDTPADMCERLHEDA
                     ETLWQVMRDKLGEE"
                     /name="Rop family plasmid primer RNA-binding protein"
     gene            7840..8217
                     /locus_tag="R5O57_RS29150"
                     /old_locus_tag="R5O57_29150"
     CDS             7840..8217
                     /locus_tag="R5O57_RS29150"
                     /old_locus_tag="R5O57_29150"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000312627.1"
                     /translation="MAWVTVRQATELTGKARSSLYRDMAKGRVSYRTEADGGRVVDTSE
                     LIRVYGELRQDETHERDELRLSGETEKMASDALIAEIKALREEVAGLRQEMQSMRLLEH
                     KPETAETPAGTPRRWWPWGKR"
                     /name="hypothetical protein"
     gene            complement(8279..8578)
                     /locus_tag="R5O57_RS29155"
                     /old_locus_tag="R5O57_29155"
     CDS             complement(8279..8578)
                     /locus_tag="R5O57_RS29155"
                     /old_locus_tag="R5O57_29155"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001146176.1"
                     /GO_function="GO:0008657 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) inhibitor activity
                     [Evidence IEA]; GO:0042803 - protein homodimerization
                     activity [Evidence IEA]"
                     /GO_process="GO:0030541 - plasmid partitioning [Evidence
                     IEA]; GO:0051290 - protein heterotetramerization [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_001146176.1"
                     /translation="MPYDVEWKQGAIEDVTTLFDYIAENSSLWDAQNVTDRVLAAADKL
                     ADFPRLYEVDSRYGEDVRRISLMGQHVLYDVDDQTRKVRVLAVVGQRQNPHIVL"
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            complement(8568..8831)
                     /locus_tag="R5O57_RS29160"
                     /old_locus_tag="R5O57_29160"
     CDS             complement(8568..8831)
                     /locus_tag="R5O57_RS29160"
                     /old_locus_tag="R5O57_29160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000072676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000072676.1"
                     /translation="MSNTTHYENANFLRELAESLPRILPEGGPDKAALLQRLANEELAQ
                     AEYEDQVRAKVTAARADTRPGMTTEQLRQRLHGRYQELRDAV"
                     /name="hypothetical protein"
     gene            complement(9137..9556)
                     /locus_tag="R5O57_RS29165"
                     /old_locus_tag="R5O57_29165"
     CDS             complement(9137..9556)
                     /locus_tag="R5O57_RS29165"
                     /old_locus_tag="R5O57_29165"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016247941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Exc2 family lipoprotein"
                     /protein_id="WP_001254601.1"
                     /translation="MRRSGSKLCLIAMITATATLTACAPKGSVEQHTRHYVYASDDGFD
                     PNFSTQKADTTRMMVPFFRQFWDMGAKDKATGKSRSDVQQRIQQFHSQEFLNSLQGTTQ
                     FAGTDYRSKDLTPKKSRLLADTISAVYLDGYEGRQ"
                     /name="Exc2 family lipoprotein"
     gene            9959..11644
                     /locus_tag="R5O57_RS29170"
                     /old_locus_tag="R5O57_29170"
     CDS             9959..11644
                     /locus_tag="R5O57_RS29170"
                     /old_locus_tag="R5O57_29170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin-like bacteriocin tRNase domain-containing
                     protein"
                     /protein_id="WP_004178188.1"
                     /translation="MSGGDGRGPGNSGLGHNGGQASGNVNGTSGKGGPSSGGGTDPNSG
                     PGWGTTHTPNGDIHNYNPGEFGNGGSKPGGNGGNSGNHSGSSGGGQSSATAMAFGLPAL
                     ATPGAEGLALSVSGDALSAAVADVLAALKGPFKFGLWGIAIYGVLPSEIAKDDPKMMSK
                     IVTSLPADTVTETPVSSLPLDQATVSVTKRVADIVKDERQHIAVVTGRPMSVPVVDAKP
                     TKRPGVFSVSIPGLPSLQVSVPKGVPAAKAPPKGIIAEKGDSRPAGFTAGGNSREAVIR
                     FPKESGQKPVYVSVTDVLTPAQVKQRLEEEKRRQQAWDAAHPEEGLKREYDKAKAELDA
                     EDKNIATLNSRIASTEKAIPGARAAVQEADKKVKEAEANKDDFVTYNPPHEYGSGWQDQ
                     VRYLDKDIQNQNEKLKAAQTSLNEMNESLSRDKAALSGAMESRKQKEKKAKDAENKLNE
                     EKKKPRKGTKDYGHDYFPDPKTEDIKGLGELKEGKPKTPKQGGGGKRARWYGDKKRKIY
                     EWDSQHGELEGYRASDGEHLGAFDPKTGKQVKGPDPKRNIKKYL"
                     /name="colicin-like bacteriocin tRNase domain-containing
                     protein"
     gene            11654..11911
                     /locus_tag="R5O57_RS29175"
                     /old_locus_tag="R5O57_29175"
     CDS             11654..11911
                     /locus_tag="R5O57_RS29175"
                     /old_locus_tag="R5O57_29175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin immunity family protein"
                     /protein_id="WP_004152553.1"
                     /translation="MGLKLHIHWFDKKTEEFKGGEYSKDFGDDGSVIESLGMPLKDNIN
                     NGWFDVEKSWVSILQPHFKNVIDISKFDYFVSFVYRDGNW"
                     /name="cloacin immunity family protein"
     gene            11996..12145
                     /locus_tag="R5O57_RS29180"
                     /old_locus_tag="R5O57_29180"
     CDS             11996..12145
                     /locus_tag="R5O57_RS29180"
                     /old_locus_tag="R5O57_29180"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891188.1"
                     /GO_component="GO:0019867 - outer membrane [Evidence IEA]"
                     /GO_process="GO:0019835 - cytolysis [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin release lysis protein"
                     /protein_id="WP_004152552.1"
                     /translation="MKKVKVVFLFILIFSGFLLVACQANYIRDVQGGTVAPSSSSELTG
                     IAVQ"
                     /name="colicin release lysis protein"
     gene            13626..15590
                     /locus_tag="R5O57_RS29185"
                     /old_locus_tag="R5O57_29185"
     CDS             13626..15590
                     /locus_tag="R5O57_RS29185"
                     /old_locus_tag="R5O57_29185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004178196.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TraM recognition domain-containing protein"
                     /protein_id="WP_004178196.1"
                     /translation="MFNTDSLAWKWHIPELARQIYPWVSWLYQEYYGLAGAFLVIGLFF
                     GLAELWAGRMRFVGLSHKERREYADRYKRDNKRPAPFSVLASLDSPGRMVRARRHVWNY
                     AYWLTGAAGLALLGGLVVAVFIESWGETVLRPDLYANADYYLLQPANLFGIAWCAGGLA
                     VGIVLARLLAFLLLDGHFAAADEAVNAKLNQESRRSSQRTGEMTDVRHLHFGEPVPVNA
                     LADFSSEQARQEQAVFLGKDEQGKPVLVPRDTWRKTNIQILGLPGSGKSVMATNALIRC
                     VRDFGDAVVYFDPKGDAWAPHVFRAHCPDFTLLDLRPGKPAQLNLFRDLDQYALKNLLI
                     AGLNLGETGDVADHYRISEQKAAKLIAEQFPQGANIQQVLAAAYALPEALKKDVKGLIT
                     RLENVADLSVLQTDSGIDVAGIINGGGCLYVIGSMDDEAVIRVQKMLFARCAQIIIARD
                     EFREWPHVSVMLDEIKYLLSKYVLNALGTLRSRDCNLLLAHQSLGDFGQCGQDLPAEFV
                     KTTVLDNTPIRWFYRAASLESAQWAAGQTGEIRVDVERRRASREAGNVEHISGDSFIQK
                     EARPLFDVNTLQHLPDGFAVMTGLGVARMAFSSPLRVERREIPLQRFPVLAKTDPLAEF
                     RPPADGGGPKADDDFAGIY"
                     /name="TraM recognition domain-containing protein"
     gene            15590..16321
                     /locus_tag="R5O57_RS29190"
                     /old_locus_tag="R5O57_29190"
     CDS             15590..16321
                     /locus_tag="R5O57_RS29190"
                     /old_locus_tag="R5O57_29190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobC family replication-relaxation protein"
                     /protein_id="WP_004152551.1"
                     /translation="MALELYNVSHAKRQARNAEKTRLTLRWLREELCSTAELVARRLGI
                     AAVQPVYRFLDSLVAKGLLVRTKYPVDGRQVSVWGLTPHGVAFSFDEDEPLADVIPFQP
                     SRVSAAHLPHRLAVQSLRLDMEARGATGWRILHRLSLKGMKVPDALAELDGKTVAFEVE
                     RTVKSRRRYQEVVSGYLFNRKANGIDEIWYICPDRATQVRVQRAILSVDEIVNPQTGEA
                     RKTAELDRERLFACFKFMTTE"
                     /name="MobC family replication-relaxation protein"
     gene            16328..16858
                     /locus_tag="R5O57_RS29195"
                     /old_locus_tag="R5O57_29195"
     CDS             16328..16858
                     /locus_tag="R5O57_RS29195"
                     /old_locus_tag="R5O57_29195"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_004153058.1"
                     /translation="MALYMVFIEDAEDRNGERCIMPTSEHLEDMVVLAWQTGAYVFCFV
                     DRAQHLAMMKSIGMYDERLNSDEKATYFFTGKNPQWERNKPTGMKLCDYLYRKVERFAI
                     ENGVQVVDAGKCSPEQINAMIDVVSERHGESAVNEKLKAELMREYNSRYFNVPVPELPE
                     DKPARRWWPFGKK"
                     /name="hypothetical protein"
     gene            complement(16886..17065)
                     /locus_tag="R5O57_RS29200"
                     /old_locus_tag="R5O57_29200"
     CDS             complement(16886..17065)
                     /locus_tag="R5O57_RS29200"
                     /old_locus_tag="R5O57_29200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rop family plasmid primer RNA-binding protein"
                     /protein_id="WP_000165971.1"
                     /translation="MTKQEKTALNMAKFIKEQSLLLLDKLNELDMDTPADMCERLHEDA
                     ETLWQVMRDKLGEE"
                     /name="Rop family plasmid primer RNA-binding protein"
     gene            17134..17511
                     /locus_tag="R5O57_RS29205"
                     /old_locus_tag="R5O57_29205"
     CDS             17134..17511
                     /locus_tag="R5O57_RS29205"
                     /old_locus_tag="R5O57_29205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000312627.1"
                     /translation="MAWVTVRQATELTGKARSSLYRDMAKGRVSYRTEADGGRVVDTSE
                     LIRVYGELRQDETHERDELRLSGETEKMASDALIAEIKALREEVAGLRQEMQSMRLLEH
                     KPETAETPAGTPRRWWPWGKR"
                     /name="hypothetical protein"
     gene            complement(17573..17872)
                     /locus_tag="R5O57_RS29210"
                     /old_locus_tag="R5O57_29210"
     CDS             complement(17573..17872)
                     /locus_tag="R5O57_RS29210"
                     /old_locus_tag="R5O57_29210"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001146176.1"
                     /GO_function="GO:0008657 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) inhibitor activity
                     [Evidence IEA]; GO:0042803 - protein homodimerization
                     activity [Evidence IEA]"
                     /GO_process="GO:0030541 - plasmid partitioning [Evidence
                     IEA]; GO:0051290 - protein heterotetramerization [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_001146176.1"
                     /translation="MPYDVEWKQGAIEDVTTLFDYIAENSSLWDAQNVTDRVLAAADKL
                     ADFPRLYEVDSRYGEDVRRISLMGQHVLYDVDDQTRKVRVLAVVGQRQNPHIVL"
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            complement(17862..18125)
                     /locus_tag="R5O57_RS29215"
                     /old_locus_tag="R5O57_29215"
     CDS             complement(17862..18125)
                     /locus_tag="R5O57_RS29215"
                     /old_locus_tag="R5O57_29215"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000072676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000072676.1"
                     /translation="MSNTTHYENANFLRELAESLPRILPEGGPDKAALLQRLANEELAQ
                     AEYEDQVRAKVTAARADTRPGMTTEQLRQRLHGRYQELRDAV"
                     /name="hypothetical protein"
     BGC             1..16644
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          complement(2955..3533)
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="95.361"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(12249..12827)
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="95.361"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          6297..7024
                     /name="MOBC"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="1.35e-150"
     Typing          15591..16318
                     /name="MOBC"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="1.35e-150"
ORIGIN
        1 tgaatgcgtt gctgcacatc actccgtgat tttccggtcg ctttatcctt tgcgcccata
       61 tcccagaact gccgaaaaaa ggcaccatca ttcgtgttgt gtcagctttc tgggtggaaa
      121 aattgggatc aaaaccgtca tctgaagcat atacgtaatg ccgggtatgc tgttccacgc
      181 tgccctttgg agcacaggca gtgagagttg ctgtcgctgt tatcatggcg ataagacaca
      241 gtttgctgcc ggaacgtctc atgagcgtct ccttaccttt aattcttttt tctcattgag
      301 ttatatatcc gcaggctatc ttatcatcag tttctgaccg tgttcagtga ccgaacaacc
      361 cgaaccagac cccccgtttc ttttcctgtc ccggaggggg ctttctggta tctcatataa
      421 tgatttcagt aaaacatact gaggccggag aacggcgccg tttgtgctgg tttttgttgc
      481 atctggaggg gattgcgcat ggtgtgagtg gctgtttttt tgatcatttt cacaaaaacg
      541 caaatttaca gacttgacat gaaaaacaag gcagcgtaat ttttatactg tatataaaac
      601 cagtggttat atgtacagta ttttatttta gtttattgtt ttaaaagtca aagaggaaaa
      661 gtatatgagt ggcggagacg gacgaggtcc gggtaattca ggtctgggac acaatggtgg
      721 tcaggccagt gggaatgtga acggtacatc aggtaaaggt ggcccttcat caggtggtgg
      781 tacggatcca aacagcgggc cgggctgggg tacgacgcat acacctaacg gggatattca
      841 taactataac ccgggggagt ttggtaacgg cgggagtaaa cccggtggta atggcggtaa
      901 cagcggcaat catagcggga gctctggtgg cggacagtct tcggccaccg cgatggcctt
      961 cggtctgcct gccttggcca ctccgggggc tgaaggactg gctttatccg tttccggcga
     1021 tgcgttgtcg gccgctgttg ctgatgtgct ggctgccctg aaaggtccgt ttaagtttgg
     1081 tctgtggggg attgcgattt acggagtgct gccttctgag atagcaaaag atgatccgaa
     1141 aatgatgtca aaaatcgtga cgtcattgcc ggcagacacg gtaacggaga cgccggtcag
     1201 ctccctgccg ctggaccagg cgacggtcag cgtcactaaa cgtgtggcgg atattgtgaa
     1261 ggacgagcgg cagcatattg cggttgtcac cggccggcca atgagtgttc ctgtggtgga
     1321 tgcgaaaccg acaaaacgtc cgggggtatt cagtgtgtcg attccgggtc tcccgtctct
     1381 gcaggtgagc gtacctaaag gtgttccggc cgcgaaagcc ccgccaaaag gcattattgc
     1441 tgaaaaaggt gattcacgtc cggctggttt tacggccggt ggtaactccc gtgaagccgt
     1501 tattcgtttc ccgaaagaga gcggacagaa accggtctat gtgtcggtga cggatgttct
     1561 tactccggca caggtaaaac agcgtctgga ggaagaaaag cgtcgccagc aggcatggga
     1621 cgctgctcac ccggaagagg ggctgaaaag agagtatgat aaagcgaaag ctgagctgga
     1681 tgctgaagat aaaaatattg cgaccttaaa cagtcgcatt gcatcgacag agaaggcgat
     1741 ccccggtgca agggctgctg ttcaggaagc cgataaaaag gtaaaagagg cagaggcaaa
     1801 taaagatgat tttgtgactt ataacccgcc tcatgaatat ggctccgggt ggcaggatca
     1861 ggttcgctat cttgataagg atattcagaa tcagaatgag aaattaaaag ctgcccagac
     1921 atctttaaac gaaatgaatg aatccttatc cagggataag gctgcgcttt ccggggcgat
     1981 ggagagccgg aaacaaaagg agaaaaaagc gaaggatgca gaaaataaat taaatgagga
     2041 aaagaaaaaa cctcgtaagg gaactaaaga ttacggccat gattattttc ctgatcccaa
     2101 gactgaagat attaaggggt tgggagagtt gaaagagggt aaacctaaaa cccctaaaca
     2161 aggtggtggt ggtaagcggg cccgatggta tggtgataaa aagcgtaaaa tttatgaatg
     2221 ggattcccag cacggtgagc ttgaagggta ccgcgccagt gatggcgaac acctcggggc
     2281 attcgatcca aaaacgggta agcaggttaa agggccggat ccaaaacgaa acattaaaaa
     2341 atatctttaa gaggtaaata tggggcttaa attacatatt cattggtttg ataagaaaac
     2401 cgaagagttt aaaggtggtg aatactcaaa agacttcggt gatgatggtt ctgtcattga
     2461 aagtctgggg atgcctttaa aggataatat taataatggt tggtttgatg ttgaaaaatc
     2521 atgggtttcg atattacagc cacactttaa aaatgtaatc gatattagta aatttgatta
     2581 ctttgtatcc tttgtttacc gggatggtaa ctggtaagca aaagttatca aggatgattt
     2641 gaaatacaga cttccggtgt tcagggatga ataccggggt ttttaaatac agggaaggta
     2701 tatgaaaaag gtaaaggttg tttttctttt tatattgatt ttttcaggct ttcttctggt
     2761 cgcatgtcag gcaaactata tccgggatgt tcagggtgga acggtggcac catcgtcctc
     2821 ctctgaactg acggggatcg cggttcagta gaaaagatca aaggatcttc ttgagatcct
     2881 ttttttctgc gcgtaatctt ttgccctgta aacgaaaaaa ccacctgggg aggtggtttg
     2941 atcgaaggtt aagtcagttg gggaactgct taaccgtggt aactggcttt cgcagagcac
     3001 agcaaccaaa tctgtccttc cagtgtagcc ggactttggc gcacacttca agagcaaccg
     3061 cgtgtttagc taaacaaatc ctctgcgaac tcccagttac caatggctgc tgccagtggc
     3121 gttttgcgtg cttttccggg ttggactcaa gtgaacagtt accggataag gcgcagcagt
     3181 cgggctgaac ggggggttct tgcttacagc ccagcttgga gcgaacgacc tacaccgagc
     3241 cgagatacca gagtgtgagc tatgagaaag cgccacactt cccgcaaggg agaaaggcgg
     3301 aacaggtatc cgggaaacgg cagggttgga acaggagagc gcaagaggga gcgattcatc
     3361 ggaaacggtg atgatcttta agtcctgtcg ggtttcgcca ctcctgactg attcatggtt
     3421 gagccaccgg ctcccacaga tgcaccgaaa aagcgtctgt ttatgtgaac tcagtcagga
     3481 gggcggagcc tatggaaaaa cgccacctgc gtggccttgc cgttttgcct cacatgttag
     3541 tcccctgctt attcacggaa tctgtgggta actttgcatg tgtccgcagc gcccgccgca
     3601 gtctcacggc cggagcgtag cgaccgagtg agcgaggagg cgcaatttcc ccggcaccta
     3661 caagacggac accggacgcg ctgatgtggc atattgtccc ctgattaagt ctttatattc
     3721 cctgataata aattaccagg ataggtgaat catatcggtt tttcgctgaa cattttacgt
     3781 taacctatct ctgttgcttt tttctcctta cggagaaata caggtcatcc ccgcgagggc
     3841 gtggctgacc tcagggggat atcccctgct tacgctggct ggacgccacc gacgcacggt
     3901 ctctccccct ctttctggct ccgtccggct ggacgccggc cacgccagaa attcacccgg
     3961 cccccgtcag gctcacgcct gaccacccac aaaaatccac ggtgctggac gcacctggcg
     4021 aagcagcaaa gctgctcctg attttgcggg tggtcagccg ctcgctatgg cgaactctga
     4081 cgggggccgg aacaccggaa aagaccgcac tggggtgccg ccttttcctc tcacacgctg
     4141 gggcgtgctc gttgttcctc cggggctgcg ccttttccgc atggggcgga aagaggctgg
     4201 cctccgtggt gaaagctgaa cgcaatcacc acggacgtga ccgccgccgc catgccttgg
     4261 ggcatgtccg cggcttgtgc agcgggggct gcacatcacg ccggcaaacc atcgtctgaa
     4321 ggagagagaa catgtttaat acggattcgc ttgcctggaa gtggcacatt ccggagctgg
     4381 cccggcagat ttatccgtgg gtcagctggc tgtaccagga gtattacggt ctggccgggg
     4441 ctttcctagt tatcggcctg tttttcggtc tggctgaact ttgggccgga cggatgcgtt
     4501 ttgtggggct gagtcataag gagcgacggg agtatgccga tcgctataag cgcgataata
     4561 aacggccagc gccattttcg gtgctggcct cgctggattc gcccgggcgg atggtcaggg
     4621 cacgtcgaca tgtctggaac tacgcgtact ggctgaccgg cgcggccggt ctggcccttc
     4681 tgggggggct ggttgtcgcc gtgtttatcg agagctgggg agaaaccgtc ctgcgtccgg
     4741 acctctacgc aaacgcagat tattacctgc tgcagccggc taacctgttc gggattgcct
     4801 ggtgcgcggg cgggctggct gtcgggattg tgttggcgcg gctgctggcg ttcctgctgc
     4861 ttgacggtca ttttgcggct gctgacgagg cggtgaacgc gaaactgaat caggagagcc
     4921 ggcgcagcag ccagcggaca ggagagatga ccgacgtgcg ccacctgcat ttcggggagc
     4981 cggtaccggt taatgcgctg gccgattttt cctcggagca ggcccggcag gagcaggcgg
     5041 tgtttctggg taaggatgag cagggcaagc cggtgctggt tccgcgtgat acctggcgca
     5101 agaccaacat tcagatcctc ggcctgcccg ggagcggcaa gagcgtgatg gccaccaacg
     5161 cgctcattcg ctgcgtacgc gatttcgggg acgcggtggt gtacttcgac cccaaagggg
     5221 acgcatgggc gccgcacgtc ttccgggcgc actgtccgga cttcaccctg ctggatctgc
     5281 ggccggggaa accggcgcag ctgaatctgt tccgcgatct cgaccagtac gcgctgaaaa
     5341 acctgctgat tgccgggctt aacctgggcg agaccggcga cgtggcggac cactaccgca
     5401 tcagcgagca gaaagcggcg aagctgattg cggagcagtt tccgcagggg gcaaacattc
     5461 agcaggtgct ggcggcggcg tacgcgctgc cggaggccct gaaaaaggac gtgaaggggt
     5521 tgatcactag gctggaaaac gtcgctgacc tgagcgtcct gcagacggac agtggcatcg
     5581 atgtggcggg gattatcaac ggcggcggct gcctgtacgt tatcggctcg atggacgacg
     5641 aggcggtgat ccgtgtgcaa aaaatgctgt ttgcccgctg cgcgcaaatc atcattgcgc
     5701 gggacgagtt ccgggagtgg ccacacgtca gcgtgatgct cgatgaaatt aaatatctgc
     5761 tgtcgaagta tgtactgaac gcactgggga cgctgcgcag ccgggactgc aatctgttgc
     5821 tcgcgcacca gtcgctgggc gatttcgggc agtgcgggca ggatctgccc gctgaatttg
     5881 tgaaaaccac ggtactggat aacacgccga tccgctggtt ttaccgggcg gccagcctgg
     5941 agtccgcgca gtgggcggcg gggcagaccg gggaaatcag ggtggacgtg gagcgccgcc
     6001 gtgccagccg ggaggcgggg aacgtggagc atatcagcgg ggacagcttc atccagaagg
     6061 aggcgcggcc gctgtttgac gtgaacaccc tgcaacacct gccggacggg ttcgcggtca
     6121 tgaccgggct gggtgtggcc cggatggcgt tcagcagtcc gctgcgggtt gagcgccggg
     6181 aaatcccgtt gcagcgtttc ccggtgctgg cgaaaaccga tcccctggcg gagttccggc
     6241 ccccggccga cggcggcggg ccgaaagcgg atgatgattt tgcggggatt tactgatggc
     6301 gctggagctg tacaacgtca gccacgcgaa acgacaggcg cggaacgcgg agaaaacccg
     6361 gctgaccctg cgctggttgc gggaagagct gtgttccacg gcggagctgg ttgcgcggcg
     6421 gctggggatt gcggcggtgc agccggtcta ccgcttcctc gacagcctgg tggcgaaagg
     6481 gctgctggtc cggaccaaat atccggtgga cggccgtcag gtcagcgtgt gggggctgac
     6541 gccgcatggc gtggcgttct cgttcgacga ggacgaaccg ctggcggatg ttattccgtt
     6601 tcagccgtca agggtgtcgg cagcacatct gccgcaccgg ctggccgtgc aatccctgcg
     6661 ccttgatatg gaagccagag gggccaccgg ctggcgcatt ctgcaccgtc tgagtcttaa
     6721 aggcatgaaa gtgccggacg ccctggcgga gctggacggt aaaacggtgg cgtttgaggt
     6781 ggagcgcacc gtcaagagcc gtcgccggta tcaggaagtg gtgtccgggt atctgttcaa
     6841 ccgcaaagct aacggcatcg atgaaatctg gtacatctgc ccggaccggg cgacgcaggt
     6901 cagggtgcag cgggcaatcc tgtcggtgga tgaaatcgtg aacccacaga ccggcgaggc
     6961 ccgcaaaacg gcagagctgg atcgtgaacg gttgtttgcg tgctttaaat ttatgacaac
     7021 ggagtgaggg attatggcgc tgtacatggt atttattgaa gacgcggagg accggaacgg
     7081 cgagcgctgc atcatgccga ccagcgagca tctggaagat atggtggtgc tcgcctggca
     7141 gaccggggcg tatgttttct gttttgtcga ccgggcccag catctggcga tgatgaaatc
     7201 catcgggatg tatgacgagc ggctcaacag cgacgaaaaa gccacgtact ttttcactgg
     7261 taaaaatccg caatgggaac ggaacaaacc cacaggaatg aagctgtgtg attacctcta
     7321 tcgcaaggtg gagcggttcg ccatcgagaa cggtgtgcag gtggttgatg ccgggaagtg
     7381 ctcaccggag cagattaacg cgatgattga cgtggtgagt gagcggcacg gggaaagcgc
     7441 ggtgaacgag aagctgaaag cggagctgat gcgggaatat aacagccgct attttaacgt
     7501 gccggtacct gaactgccgg aggacaaacc tgcccgccgg tggtggccgt tcggcaaaaa
     7561 ataaatgcca gcaccggcca tgccggtgct gttattcctc cccgagctta tcccgcatca
     7621 cctgccagag tgtttccgca tcctcgtgta gccgctcgca catgtcggcc ggggtatcca
     7681 tatccagctc attcagttta tcgagcaata gcagcgactg ctccttaata aatttagcca
     7741 tattgagggc tgttttttcc tgttttgtca tgattctttc cttccgggca tggtgtgcgc
     7801 ctgtcaggta tactgtctca aaaatagcgg ggtgagacaa tggcgtgggt gacggtgaga
     7861 caggcgacgg aactgacggg taaagcccga agttccctgt atcgggatat ggcgaaaggc
     7921 cgcgtatcat accgtacgga agctgatggc ggccgggtgg tggataccag cgagcttatc
     7981 cgggtgtacg gtgagttaag acaggatgag actcacgagc gggacgagtt gagactgtcg
     8041 ggtgagactg aaaaaatggc ctccgacgcg ttgatcgcgg agataaaagc actcagggag
     8101 gaggtggccg ggctacggca ggaaatgcag tccatgagac tgctggaaca caaaccggag
     8161 acagcagaga ccccggccgg aacaccgcgc cggtggtggc cgtggggaaa acgctgacgc
     8221 gctgtgcttg tccaaccggc gacggccacg caatgaattg cgtccccgtc accggttatt
     8281 agagaacaat atggggattc tggcgctggc cgaccacggc cagaacccgg acttttctgg
     8341 tctggtcatc aacatcatag aggacatgct gtcccatcag actgatccgg cgaacgtcct
     8401 cgccatagcg tgagtccact tcatagagtc gcgggaagtc ggccagtttg tccgccgcag
     8461 cgagaacccg gtcggtaacg ttctgcgcat cccacaggga tgaattttcc gcgatatagt
     8521 caaacagcgt cgttacatcc tcgatggctc cctgcttcca ttccacgtca tacggcatcg
     8581 cgcagttcct gataacggcc atgcaggcgc tggcggagtt gttccgtggt catacccgga
     8641 cgcgtgtcag cacgggcggc ggtcactttg gcgcgaacct gatcttcata ctctgcctgg
     8701 gccagttctt cgttagccag tcgctgcaac agcgcagctt tgtccgggcc accttccggc
     8761 agtatgcggg gcaggctttc agccagttcc cgaagaaagt tggcgttttc gtagtgtgta
     8821 gtgttgctca ttgcggagcc tcccgggtta atgcggcaat atgaaggaag tttagcaggg
     8881 ggcggtctga aagaatatgg tcgtgtcagt caggctgatg aagcagaaag tcggtaaaaa
     8941 agggcttacg gcatccattt tacgtcaaaa catatgccat gcagttgcgt gcataggcat
     9001 gcattaggat aaaatttatc gggcgcgttt ccggcagttt tccggggggg ttgttgcctg
     9061 ttttatcccg tagccgccgg aaacgccctg agcccgtctg agcggtgcgc gtaatgacgc
     9121 gttatggtaa atccacttac tgtctgcctt catagccatc gagataaaca gctgaaatgg
     9181 tgtcagccag tagccttgat tttttcggtg tgaggtcttt gctgcggtaa tcggtacccg
     9241 caaattgtgt tgtgccttgg agtgagttta aaaattcctg actgtgaaac tgctgaatgc
     9301 gttgctgcac atcactccgt gattttccgg tcgctttatc ctttgcgccc atatcccaga
     9361 actgccggaa aaaaggcacc atcattcgtg ttgtgtcagc tttctgggtg gaaaaattgg
     9421 gatcaaaacc gtcatctgaa gcatatacgt aatgccgggt atgctgttcc acgctgccct
     9481 ttggagcaca ggcagtgaga gttgctgtcg ctgttatcat ggcgataaga cacagtttgc
     9541 tgccggaacg tctcatgagc gtctccttac ctttaattct tttttctcat tgagttatat
     9601 atccgcaggc tatcttatca tcagtttctg accgtgttca gtgaccgaac aacccgaacc
     9661 agaccccccg tttcttttcc tgtcccggag ggggctttct ggtatctcat ataatgattt
     9721 cagtaaaaca tactgaggcc ggagaacggc gccgtttgtg ctggtttttg ttgcatctgg
     9781 aggggattgc gcatggtgtg agtggctgtt tttttgatca ttttcacaaa aacgcaaatt
     9841 tacagacttg acatgaaaaa caaggcagcg taatttttat actgtatata aaaccagtgg
     9901 ttatatgtac agtattttat tttagtttat tgttttaaaa gtcaaagagg aaaagtatat
     9961 gagtggcgga gacggacgag gtccgggtaa ttcaggtctg ggacacaatg gtggtcaggc
    10021 cagtgggaat gtgaacggta catcaggtaa aggtggccct tcatcaggtg gtggtacgga
    10081 tccaaacagc gggccgggct ggggtacgac gcatacacct aacggggata ttcataacta
    10141 taacccgggg gagtttggta acggcgggag taaacccggt ggtaatggcg gtaacagcgg
    10201 caatcatagc gggagctctg gtggcggaca gtcttcggcc accgcgatgg ccttcggtct
    10261 gcctgccttg gccactccgg gggctgaagg actggcttta tccgtttccg gcgatgcgtt
    10321 gtcggccgct gttgctgatg tgctggctgc cctgaaaggt ccgtttaagt ttggtctgtg
    10381 ggggattgcg atttacggag tgctgccttc tgagatagca aaagatgatc cgaaaatgat
    10441 gtcaaaaatc gtgacgtcat tgccggcaga cacggtaacg gagacgccgg tcagctccct
    10501 gccgctggac caggcgacgg tcagcgtcac taaacgtgtg gcggatattg tgaaggacga
    10561 gcggcagcat attgcggttg tcaccggccg gccaatgagt gttcctgtgg tggatgcgaa
    10621 accgacaaaa cgtccggggg tattcagtgt gtcgattccg ggtctcccgt ctctgcaggt
    10681 gagcgtacct aaaggtgttc cggccgcgaa agccccgcca aaaggcatta ttgctgaaaa
    10741 aggtgattca cgtccggctg gttttacggc cggtggtaac tcccgtgaag ccgttattcg
    10801 tttcccgaaa gagagcggac agaaaccggt ctatgtgtcg gtgacggatg ttcttactcc
    10861 ggcacaggta aaacagcgtc tggaggaaga aaagcgtcgc cagcaggcat gggacgctgc
    10921 tcacccggaa gaggggctga aaagagagta tgataaagcg aaagctgagc tggatgctga
    10981 agataaaaat attgcgacct taaacagtcg cattgcatcg acagagaagg cgatccccgg
    11041 tgcaagggct gctgttcagg aagccgataa aaaggtaaaa gaggcagagg caaataaaga
    11101 tgattttgtg acttataacc cgcctcatga atatggctcc gggtggcagg atcaggttcg
    11161 ctatcttgat aaggatattc agaatcagaa tgagaaatta aaagctgccc agacatcttt
    11221 aaacgaaatg aatgaatcct tatccaggga taaggctgcg ctttccgggg cgatggagag
    11281 ccggaaacaa aaggagaaaa aagcgaagga tgcagaaaat aaattaaatg aggaaaagaa
    11341 aaaacctcgt aagggaacta aagattacgg ccatgattat tttcctgatc ccaagactga
    11401 agatattaag gggttgggag agttgaaaga gggtaaacct aaaaccccta aacaaggtgg
    11461 tggtggtaag cgggcccgat ggtatggtga taaaaagcgt aaaatttatg aatgggattc
    11521 ccagcacggt gagcttgaag ggtaccgcgc cagtgatggc gaacacctcg gggcattcga
    11581 tccaaaaacg ggtaagcagg ttaaagggcc ggatccaaaa cgaaacatta aaaaatatct
    11641 ttaagaggta aatatggggc ttaaattaca tattcattgg tttgataaga aaaccgaaga
    11701 gtttaaaggt ggtgaatact caaaagactt cggtgatgat ggttctgtca ttgaaagtct
    11761 ggggatgcct ttaaaggata atattaataa tggttggttt gatgttgaaa aatcatgggt
    11821 ttcgatatta cagccacact ttaaaaatgt aatcgatatt agtaaatttg attactttgt
    11881 atcctttgtt taccgggatg gtaactggta agcaaaagtt atcaaggatg atttgaaata
    11941 cagacttccg gtgttcaggg atgaataccg gggtttttaa atacagggaa ggtatatgaa
    12001 aaaggtaaag gttgtttttc tttttatatt gattttttca ggctttcttc tggtcgcatg
    12061 tcaggcaaac tatatccggg atgttcaggg tggaacggtg gcaccatcgt cctcctctga
    12121 actgacgggg atcgcggttc agtagaaaag atcaaaggat cttcttgaga tccttttttt
    12181 ctgcgcgtaa tcttttgccc tgtaaacgaa aaaaccacct ggggaggtgg tttgatcgaa
    12241 ggttaagtca gttggggaac tgcttaaccg tggtaactgg ctttcgcaga gcacagcaac
    12301 caaatctgtc cttccagtgt agccggactt tggcgcacac ttcaagagca accgcgtgtt
    12361 tagctaaaca aatcctctgc gaactcccag ttaccaatgg ctgctgccag tggcgttttg
    12421 cgtgcttttc cgggttggac tcaagtgaac agttaccgga taaggcgcag cagtcgggct
    12481 gaacgggggg ttcttgctta cagcccagct tggagcgaac gacctacacc gagccgagat
    12541 accagagtgt gagctatgag aaagcgccac acttcccgca agggagaaag gcggaacagg
    12601 tatccgggaa acggcagggt tggaacagga gagcgcaaga gggagcgatt catcggaaac
    12661 ggtgatgatc tttaagtcct gtcgggtttc gccactcctg actgattcat ggttgagcca
    12721 ccggctccca cagatgcacc gaaaaagcgt ctgtttatgt gaactcagtc aggagggcgg
    12781 agcctatgga aaaacgccac ctgcgtggcc ttgccgtttt gcctcacatg ttagtcccct
    12841 gcttattcac ggaatctgtg ggtaactttg catgtgtccg cagcgcccgc cgcagtctca
    12901 cggccggagc gtagcgaccg agtgagcgag gaggcgcaat ttccccggca cctacaagac
    12961 ggacaccgga cgcgctgatg tggcatattg tcccctgatt aagtctttat attccctgat
    13021 aataaattac caggataggt gaatcatatc ggtttttcgc tgaacatttt acgttaacct
    13081 atctctgttg cttttttctc cttacggaga aatacaggtc atccccgcga gggcgtggct
    13141 gacctcaggg ggatatcccc tgcttacgct ggctggacgc caccgacgca cggtctctcc
    13201 ccctctttct ggctccgtcc ggctggacgc cggccacgcc agaaattcac ccggcccccg
    13261 tcaggctcac gcctgaccac ccacaaaaat ccacggtgct ggacgcacct ggcgaagcag
    13321 caaagctgct cctgattttg cgggtggtca gccgctcgct atggcgaact ctgacggggg
    13381 ccggaacacc ggaaaagacc gcactggggt gccgcctttt cctctcacac gctggggcgt
    13441 gctcgttgtt cctccggggc tgcgcctttt ccgcatgggg cggaaagagg ctggcctccg
    13501 tggtgaaagc tgaacgcaat caccacggac gtgaccgccg ccgccatgcc ttggggcatg
    13561 tccgcggctt gtgcagcggg ggctgcacat cacgccggca aaccatcgtc tgaaggagag
    13621 agaacatgtt taatacggat tcgcttgcct ggaagtggca cattccggag ctggcccggc
    13681 agatttatcc gtgggtcagc tggctgtacc aggagtatta cggtctggcc ggggctttcc
    13741 tagttatcgg cctgtttttc ggtctggctg aactttgggc cggacggatg cgttttgtgg
    13801 ggctgagtca taaggagcga cgggagtatg ccgatcgcta taagcgcgat aataaacggc
    13861 cagcgccatt ttcggtgctg gcctcgctgg attcgcccgg gcggatggtc agggcacgtc
    13921 gacatgtctg gaactacgcg tactggctga ccggcgcggc cggtctggcc cttctggggg
    13981 ggctggttgt cgccgtgttt atcgagagct ggggagaaac cgtcctgcgt ccggacctct
    14041 acgcaaacgc agattattac ctgctgcagc cggctaacct gttcgggatt gcctggtgcg
    14101 cgggcgggct ggctgtcggg attgtgttgg cgcggctgct ggcgttcctg ctgcttgacg
    14161 gtcattttgc ggctgctgac gaggcggtga acgcgaaact gaatcaggag agccggcgca
    14221 gcagccagcg gacaggagag atgaccgacg tgcgccacct gcatttcggg gagccggtac
    14281 cggttaatgc gctggccgat ttttcctcgg agcaggcccg gcaggagcag gcggtgtttc
    14341 tgggtaagga tgagcagggc aagccggtgc tggttccgcg tgatacctgg cgcaagacca
    14401 acattcagat cctcggcctg cccgggagcg gcaagagcgt gatggccacc aacgcgctca
    14461 ttcgctgcgt acgcgatttc ggggacgcgg tggtgtactt cgaccccaaa ggggacgcat
    14521 gggcgccgca cgtcttccgg gcgcactgtc cggacttcac cctgctggat ctgcggccgg
    14581 ggaaaccggc gcagctgaat ctgttccgcg atctcgacca gtacgcgctg aaaaacctgc
    14641 tgattgccgg gcttaacctg ggcgagaccg gcgacgtggc ggaccactac cgcatcagcg
    14701 agcagaaagc ggcgaagctg attgcggagc agtttccgca gggggcaaac attcagcagg
    14761 tgctggcggc ggcgtacgcg ctgccggagg ccctgaaaaa ggacgtgaag gggttgatca
    14821 ctaggctgga aaacgtcgct gacctgagcg tcctgcagac ggacagtggc atcgatgtgg
    14881 cggggattat caacggcggc ggctgcctgt acgttatcgg ctcgatggac gacgaggcgg
    14941 tgatccgtgt gcaaaaaatg ctgtttgccc gctgcgcgca aatcatcatt gcgcgggacg
    15001 agttccggga gtggccacac gtcagcgtga tgctcgatga aattaaatat ctgctgtcga
    15061 agtatgtact gaacgcactg gggacgctgc gcagccggga ctgcaatctg ttgctcgcgc
    15121 accagtcgct gggcgatttc gggcagtgcg ggcaggatct gcccgctgaa tttgtgaaaa
    15181 ccacggtact ggataacacg ccgatccgct ggttttaccg ggcggccagc ctggagtccg
    15241 cgcagtgggc ggcggggcag accggggaaa tcagggtgga cgtggagcgc cgccgtgcca
    15301 gccgggaggc ggggaacgtg gagcatatca gcggggacag cttcatccag aaggaggcgc
    15361 ggccgctgtt tgacgtgaac accctgcaac acctgccgga cgggttcgcg gtcatgaccg
    15421 ggctgggtgt ggcccggatg gcgttcagca gtccgctgcg ggttgagcgc cgggaaatcc
    15481 cgttgcagcg tttcccggtg ctggcgaaaa ccgatcccct ggcggagttc cggcccccgg
    15541 ccgacggcgg cgggccgaaa gcggatgatg attttgcggg gatttactga tggcgctgga
    15601 gctgtacaac gtcagccacg cgaaacgaca ggcgcggaac gcggagaaaa cccggctgac
    15661 cctgcgctgg ttgcgggaag agctgtgttc cacggcggag ctggttgcgc ggcggctggg
    15721 gattgcggcg gtgcagccgg tctaccgctt cctcgacagc ctggtggcga aagggctgct
    15781 ggtccggacc aaatatccgg tggacggccg tcaggtcagc gtgtgggggc tgacgccgca
    15841 tggcgtggcg ttctcgttcg acgaggacga accgctggcg gatgttattc cgtttcagcc
    15901 gtcaagggtg tcggcagcac atctgccgca ccggctggcc gtgcaatccc tgcgccttga
    15961 tatggaagcc agaggggcca ccggctggcg cattctgcac cgtctgagtc ttaaaggcat
    16021 gaaagtgccg gacgccctgg cggagctgga cggtaaaacg gtggcgtttg aggtggagcg
    16081 caccgtcaag agccgtcgcc ggtatcagga agtggtgtcc gggtatctgt tcaaccgcaa
    16141 agctaacggc atcgatgaaa tctggtacat ctgcccggac cgggcgacgc aggtcagggt
    16201 gcagcgggca atcctgtcgg tggatgaaat cgtgaaccca cagaccggcg aggcccgcaa
    16261 aacggcagag ctggatcgtg aacggttgtt tgcgtgcttt aaatttatga caacggagtg
    16321 agggattatg gcgctgtaca tggtatttat tgaagacgcg gaggaccgga acggcgagcg
    16381 ctgcatcatg ccgaccagcg agcatctgga agatatggtg gtgctcgcct ggcagaccgg
    16441 ggcgtatgtt ttctgttttg tcgaccgggc ccagcatctg gcgatgatga aatccatcgg
    16501 gatgtatgac gagcggctca acagcgacga aaaagccacg tactttttca ctggtaaaaa
    16561 tccgcaatgg gaacggaaca aacccacagg aatgaagctg tgtgattacc tctatcgcaa
    16621 ggtggagcgg ttcgccatcg agaacggtgt gcaggtggtt gatgccggga agtgctcacc
    16681 ggagcagatt aacgcgatga ttgacgtggt gagtgagcgg cacggggaaa gcgcggtgaa
    16741 cgagaagctg aaagcggagc tgatgcggga atataacagc cgctatttta acgtgccggt
    16801 acctgaactg ccggaggaca aacctgcccg ccggtggtgg ccgttcggca aaaaataaat
    16861 gccagcaccg gccatgccgg tgctgttatt cctccccgag cttatcccgc atcacctgcc
    16921 agagtgtttc cgcatcctcg tgtagccgct cgcacatgtc ggccggggta tccatatcca
    16981 gctcattcag tttatcgagc aatagcagcg actgctcctt aataaattta gccatattga
    17041 gggctgtttt ttcctgtttt gtcatgattc tttccttccg ggcatggtgt gcgcctgtca
    17101 ggtatactgt ctcaaaaata gcggggtgag acaatggcgt gggtgacggt gagacaggcg
    17161 acggaactga cgggtaaagc ccgaagttcc ctgtatcggg atatggcgaa aggccgcgta
    17221 tcataccgta cggaagctga tggcggccgg gtggtggata ccagcgagct tatccgggtg
    17281 tacggtgagt taagacagga tgagactcac gagcgggacg agttgagact gtcgggtgag
    17341 actgaaaaaa tggcctccga cgcgttgatc gcggagataa aagcactcag ggaggaggtg
    17401 gccgggctac ggcaggaaat gcagtccatg agactgctgg aacacaaacc ggagacagca
    17461 gagaccccgg ccggaacacc gcgccggtgg tggccgtggg gaaaacgctg acgcgctgtg
    17521 cttgtccaac cggcgacggc cacgcaatga attgcgtccc cgtcaccggt tattagagaa
    17581 caatatgggg attctggcgc tggccgacca cggccagaac ccggactttt ctggtctggt
    17641 catcaacatc atagaggaca tgctgtccca tcagactgat ccggcgaacg tcctcgccat
    17701 agcgtgagtc cacttcatag agtcgcggga agtcggccag tttgtccgcc gcagcgagaa
    17761 cccggtcggt aacgttctgc gcatcccaca gggatgaatt ttccgcgata tagtcaaaca
    17821 gcgtcgttac atcctcgatg gctccctgct tccattccac gtcatacggc atcgcgcagt
    17881 tcctgataac ggccatgcag gcgctggcgg agttgttccg tggtcatacc cggacgcgtg
    17941 tcagcacggg cggcggtcac tttggcgcga acctgatctt catactctgc ctgggccagt
    18001 tcttcgttag ccagtcgctg caacagcgca gctttgtccg ggccaccttc cggcagtatg
    18061 cggggcaggc tttcagccag ttcccgaaga aagttggcgt tttcgtagtg tgtagtgttg
    18121 ctcattgcgg agcctcccgg gttaatgcgg caatatgaag gaagtttagc agggggcggt
    18181 ctgaaagaat atggtcgtgt cagtcaggct gatgaagcag aaagtcggta aaaaagggct
    18241 tacggcatcc attttacgtc aaaacatatg ccatgcagtt gcgtgcatag gcatgcatta
    18301 ggataaaatt tatcgggcgc gtttccggca gttttccggg ggggttgttg cctgttttat
    18361 cccgtagccc gccggaaacg ccctgagccc gtctgagcgg tgcgcgtaat gacgcgttat
    18421 ggtaaatcca cttactgtct gccttcatag ccatcgagat aaacagctga aatggtgtca
    18481 gccagtagcc ttgatttttt cggtgtgagg tctttgctgc ggtaatcggt acccgcaaat
    18541 tgtgttgtgc cttggagtga gtttaaaaat tcctgactgt gaaactgc
//
