LOCUS       NZ_CP131812            28013 bp    DNA     circular CON 25-APR-2024
DEFINITION  Enterococcus faecium strain 2016C08-243 plasmid p2016C08-243-3,
            complete sequence.
ACCESSION   NZ_CP131812
VERSION     NZ_CP131812.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN36766203
            Assembly: GCF_038439085.1
KEYWORDS    RefSeq.
SOURCE      Enterococcus faecium
  ORGANISM  Enterococcus faecium
            Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
            Enterococcus.
REFERENCE   1  (bases 1 to 28013)
  AUTHORS   Chen,F.-J., Liao,Y.-C. and Chiu,Y.-T.
  TITLE     Rapid Diagnostics and Real-time Genomic Surveillance System for
            Pathogens from Culture
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 28013)
  AUTHORS   Chen,F.-J., Liao,Y.-C. and Chiu,Y.-T.
  TITLE     Direct Submission
  JOURNAL   Submitted (31-JUL-2023) National Institute of Infectious Diseases
            and Vaccinology, National Health Research Institutes, No. 35, Keyan
            Road, Zhunan Town, Miaoli County 350, Taiwan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 28-SEP-2022
            Assembly Method                   :: CCBGpipe v. 1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 80x
            Sequencing Technology :: Oxford Nanopore MinION and Illumina iSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_038439085.1-RS_2024_04_24
            Annotation Date                   :: 04/24/2024 15:05:45
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,281
            CDSs (total)                      :: 3,185
            Genes (coding)                    :: 3,018
            CDSs (with protein)               :: 3,018
            Genes (RNA)                       :: 96
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 74
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 167
            CDSs (without protein)            :: 167
            Pseudo Genes (ambiguous residues) :: 0 of 167
            Pseudo Genes (frameshifted)       :: 59 of 167
            Pseudo Genes (incomplete)         :: 101 of 167
            Pseudo Genes (internal stop)      :: 39 of 167
            Pseudo Genes (multiple problems)  :: 29 of 167
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP131812.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..28013
                     /organism="Enterococcus faecium"
                     /mol_type="genomic DNA"
                     /strain="2016C08-243"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1352"
                     /plasmid="p2016C08-243-3"
                     /geo_loc_name="Taiwan"
                     /collection_date="2016"
                     /collected_by="NHRI"
     gene            join(27984..28013,1..1056)
                     /locus_tag="Q7582_RS16080"
                     /old_locus_tag="Q7582_16015"
     CDS             join(27984..28013,1..1056)
                     /locus_tag="Q7582_RS16080"
                     /old_locus_tag="Q7582_16015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002352763.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /protein_id="WP_002326891.1"
                     /translation="MSTEFQSQKMIIKNWGYKATNVYIEKYYKFPSFLIQNSKYSKMKD
                     SSKIAYMLFKNEFRRALHEKWIDDDGLLYLEFTQADLMDKLNCYQGKVKTILNELETYN
                     LISVVKGEFNPKTKKNEKNKYYLLQPEISADDLFIQNSFDDDLSETIDKSTSSRNAEIA
                     RREETAKTLDNTGNAEIARREKTAETLDNTGNAEIAQDYYINKSLDTKRHLKDTETDQL
                     QNQVLLDNFVEIMKEDSINTFVPEKVLSLIKTFSNTYEEAQQTVTTIHNAKHKAEELEK
                     TVVVYEELESYGIDADKGLYMTLLKAYQKQKTEKVNNLQNLIFVYVKNWFVEKAIAAKL
                     ANEQRETFNELPTVSTENWLE"
                     /name="replication initiator protein A"
     gene            complement(1672..2352)
                     /locus_tag="Q7582_RS16085"
                     /old_locus_tag="Q7582_16020"
     CDS             complement(1672..2352)
                     /locus_tag="Q7582_RS16085"
                     /old_locus_tag="Q7582_16020"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="WP_002343844.1"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIGADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKLYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            complement(<2857..5007)
                     /locus_tag="Q7582_RS16090"
                     /old_locus_tag="Q7582_16025"
                     /pseudo=""
     CDS             complement(<2857..5007)
                     /locus_tag="Q7582_RS16090"
                     /old_locus_tag="Q7582_16025"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000684984.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="Tn3 family transposase"
                     /name="Tn3 family transposase"
     gene            5153..5728
                     /locus_tag="Q7582_RS16095"
                     /old_locus_tag="Q7582_16030"
     CDS             5153..5728
                     /locus_tag="Q7582_RS16095"
                     /old_locus_tag="Q7582_16030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001226076.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_001226076.1"
                     /translation="MRKIGYIRVSSTNQNPSRQFQQLNEIGMDIIYEEKVSGATKDREQ
                     LQKVLDDLQEDDIIYVTDLTRITRSTQDLFELIDNIRDKKASLKSLKDTWLDLSEDNPY
                     SQFLITVMAGVNQLERDLIRMRQREGIELAKKEGKFKGRLKKYHKNHAGMNYAVKLYKE
                     GNMTVNQICEITNVSRASLYRKLSEVNN"
                     /name="recombinase family protein"
     gene            6016..7335
                     /locus_tag="Q7582_RS16100"
                     /old_locus_tag="Q7582_16035"
     CDS             6016..7335
                     /locus_tag="Q7582_RS16100"
                     /old_locus_tag="Q7582_16035"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002338419.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS1380-like element IS1678 family transposase"
                     /protein_id="WP_000202380.1"
                     /translation="MTSLHKNQVKFNSNITISHTGGQLSSDSGLVLVKELMNIFGFSEL
                     AKQHIHIEDERAYFTHDNLSILEQFIMQLIAGYSADSAANLLRQDPVFKAVLDRKELAS
                     QSSLSRFLDRLSEENIHELQALNQELIDKARLIRNDTELIIDLDSTHSDTFGHQEQTNY
                     NTHYQTYGYHPLVAFDGLTGDFLKAELRSGNQYTSKGVKEFLTPLLEHYNHSLPNTDIL
                     VRGDSGFATPGVYDSCESKKSHYVIRLKNNRRLGQIAEKSVLYGDNQKWEEREVQYFST
                     TYQAQSWSQSRRVCIRSTREAGELLFRHEFIVTNLSENVSPDTIFSIYAKRGTMENFIK
                     EAKAGFYFDKTDSPRFLENHVRMMLSLIAYNLVNFLRTIGFEEVQKGMTIHSIRLKFLK
                     VAGKLVQTGRRVYLKLSSYHVYQNEFYRVFARLRRASQWI"
                     /name="IS1380-like element IS1678 family transposase"
     gene            7625..8320
                     /gene="vanR-A"
                     /locus_tag="Q7582_RS16105"
                     /old_locus_tag="Q7582_16040"
     ARG             7626..8317
                     /name="vanR-A"
                     /gene="vanR-A"
                     /gene_name="vancomycin resistance response regulator
                     transcription factor VanR-A"
                     /tool="amrfinderplus"
                     /drug_class="GLYCOPEPTIDE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            8298..9452
                     /locus_tag="Q7582_RS16110"
                     /old_locus_tag="Q7582_16045"
     CDS             8298..9452
                     /locus_tag="Q7582_RS16110"
                     /old_locus_tag="Q7582_16045"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002305818.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="vancomycin resistance histidine kinase VanS-A"
                     /protein_id="WP_002305818.1"
                     /translation="MVIKLKNKKNDYSKLERKLYMYIVAIVVVAIVFVLYIRSMIRGKL
                     GDWILSILENKYDLNHLDAMKLYQYSIRNNIDIFIYVAIVISILILCRVMLSKFAKYFD
                     EINTGIDVLIQNEDKQIELSAEMDVMEQKLNTLKRTLEKREQDAKLAEQRKNDVVMYLA
                     HDIKTPLTSIIGYLSLLDEAPDMPVDQKAKYVHITLDKAYRLEQLIDEFFEITRYNLQT
                     ITLTKTHIDLYYMLVQMTDEFYPQLSAHGKQAVIHAPEDLTVSGDPDKLARVFNNILKN
                     AAAYSEDNSIIDITAGLSGDVVSIEFKNTGSIPKDKLAAIFEKFYRLDNARSSDTGGAG
                     LGLAIAKEIIVQHGGQIYAESNDNYTTFRVELPAMPDLVDKRRS"
                     /name="vancomycin resistance histidine kinase VanS-A"
     gene            complement(9550..10842)
                     /locus_tag="Q7582_RS16115"
                     /old_locus_tag="Q7582_16050"
     CDS             complement(9550..10842)
                     /locus_tag="Q7582_RS16115"
                     /old_locus_tag="Q7582_16050"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016628567.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ISL3-like element IS1251 family transposase"
                     /protein_id="WP_000122610.1"
                     /translation="MSYTHLIKETLDILDLSVTFNENCLTKEKYKGQICHIYRGNLIYT
                     AQECIHCKHQIASDIVRWGTTTVRLLMNDVSEYRTYLELKKQRFKCKACQRTFVADTSV
                     AKKHCFISEKVRWSVVTRLKKNTSMTEIAAQKNLSVSSVYRIMKRFYRPLNPFRTPLPK
                     VLCFDEFKSVRGVSGAMSFIMMDGQTQRLLDIVENRQLPFLKRYFSHFSREIREAVEWI
                     VIDMYAPYVSLVKKLFPKAQLIIDRFHIVQHIGRTFRNHRIKETNQLLKSKEQKHYQLG
                     KQLKRYWKLLQKDERKLDYTRRLWRPGFKAHLTETDIVDRLLKGSPALRVGYQLYQDFL
                     YAVKERDYVSFEELLTNNIMLPEGYQTTLRTFQKFLPQIKNALQQSYSNGPLECLNNHI
                     KVLKRNAYGFRSFYNFKLRIMIRHGNALIFN"
                     /name="ISL3-like element IS1251 family transposase"
     gene            11174..12142
                     /locus_tag="Q7582_RS16120"
                     /old_locus_tag="Q7582_16055"
     CDS             11174..12142
                     /locus_tag="Q7582_RS16120"
                     /old_locus_tag="Q7582_16055"
                     /EC_number="1.1.1.28"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001059542.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-lactate dehydrogenase VanH-A"
                     /protein_id="WP_001059542.1"
                     /translation="MNNIGITVYGCEQDEADAFHALSPRFGVMATIINANVSESNAKSA
                     PFNQCISVGHKSEISASILLALKRAGVKYISTRSIGCNHIDTTAAKRMGITVDNVAYSP
                     DSVADYTMMLILMAVRNVKSIVRSVEKHDFRLDSDRGKVLSDMTVGVVGTGQIGKAVIE
                     RLRGFGCKVLAYSRSRSIEVNYVPFDELLQNSDIVTLHVPLNTDTHYIISHEQIQRMKQ
                     GAFLINTGRGPLVDTYELVKALENGKLGGAALDVLEGEEEFFYSDCTQKPIDNQFLLKL
                     QRMPNVIITPHTAYYTEQALRDTVEKTIKNCLDFERRQEHE"
                     /name="D-lactate dehydrogenase VanH-A"
     gene            12135..13166
                     /gene="vanA"
                     /locus_tag="Q7582_RS16125"
                     /old_locus_tag="Q7582_16060"
     ARG             12136..13163
                     /name="vanA"
                     /gene="vanA"
                     /gene_name="D-alanine--(R)-lactate ligase VanA"
                     /tool="amrfinderplus"
                     /drug_class="GLYCOPEPTIDE"
                     /identity="99.71"
                     /coverage="100.0"
     gene            13172..13780
                     /locus_tag="Q7582_RS16130"
                     /old_locus_tag="Q7582_16065"
     CDS             13172..13780
                     /locus_tag="Q7582_RS16130"
                     /old_locus_tag="Q7582_16065"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000402347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-Ala-D-Ala dipeptidase VanX-A"
                     /protein_id="WP_000402348.1"
                     /translation="MEIGFTFLDEIVHGVRWDAKYATWDNFTGKPVDGYEVNRIVGTYE
                     LAESLLKAKELAATQGYGLLLWDGYRPNRAVNCFMQWAAQPENNLTKESYYPNIDRTEM
                     ISKGYVASKSSHSRGSAIDLTLYRLDTGELVPMGSRFDFMDERSHHAANGISCNEAQNR
                     RRLRSIMENSGFEAYSLEWWHYVLRDEPYPNSYFDFPVK"
                     /name="D-Ala-D-Ala dipeptidase VanX-A"
     gene            14208..15119
                     /gene="vanY"
                     /locus_tag="Q7582_RS16135"
                     /old_locus_tag="Q7582_16070"
     CDS             14208..15119
                     /gene="vanY"
                     /locus_tag="Q7582_RS16135"
                     /old_locus_tag="Q7582_16070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001812592.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VanY-A/VanY-F/VanY-M family D-Ala-D-Ala
                     carboxypeptidase"
                     /protein_id="WP_000732308.1"
                     /translation="MKKLFFLLLLLFLIYLGYDYVNEALFSQEKVEFQNYDQNPKEHLE
                     NSGTSENTQEKTITEEQVYQGNLLLINSKYPVRQESVKSDIVNLSKHDELINGYGLLDS
                     NIYMSKEIAQKFSEMVNDAVKGGVSHFIINSGYRDFDEQSVLYQEMGAEYALPAGYSEH
                     NSGLSLDVGSSLTKMERAPEGKWIEENAWKYGFILRYPEDKTELTGIQYELWHIRYVGL
                     PHSAIMKEKNFVLEEYMDYLKEEKTISVSVNGEKYEIFYYPVTKNTTIHVPTNLRYEIS
                     GNNIDGVIVTVFPGSTHTNSRR"
                     /name="vanY"
     gene            15272..15757
                     /gene="vanZ-A"
                     /locus_tag="Q7582_RS16140"
                     /old_locus_tag="Q7582_16075"
     ARG             15273..15754
                     /name="vanZ-A"
                     /gene="vanZ-A"
                     /gene_name="glycopeptide resistance protein VanZ-A"
                     /tool="amrfinderplus"
                     /drug_class="GLYCOPEPTIDE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(16044..16373)
                     /locus_tag="Q7582_RS16145"
                     /old_locus_tag="Q7582_16080"
     CDS             complement(16044..16373)
                     /locus_tag="Q7582_RS16145"
                     /old_locus_tag="Q7582_16080"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000754864.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_000754864.1"
                     /translation="MKKVCQVTVVHKEKVNGIKNKLDQKDFSNLLVLGKCFSDFSRIKI
                     FYALETYKEMCVCDLAEILTASVATTSHHLRFLKKHGMAKSRQDGKVVYYSLANEDILS
                     AIRVF"
                     /name="metalloregulator ArsR/SmtB family transcription
                     factor"
     gene            16678..17007
                     /locus_tag="Q7582_RS16150"
                     /old_locus_tag="Q7582_16085"
     CDS             16678..17007
                     /locus_tag="Q7582_RS16150"
                     /old_locus_tag="Q7582_16085"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005877489.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000629052.1"
                     /translation="MITKTRKQGNSIMLTVPKEFDVPNGVEVEAKLVENGILYEFVEPK
                     KEFFDFSEDILADILSEGYSKQEILKEFRNRKNALTSAFKSIAEDTVANSKPMTKEELA
                     AEIGL"
                     /name="hypothetical protein"
     gene            16997..17263
                     /locus_tag="Q7582_RS16155"
                     /old_locus_tag="Q7582_16090"
     CDS             16997..17263
                     /locus_tag="Q7582_RS16155"
                     /old_locus_tag="Q7582_16090"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016622822.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_342080286.1"
                     /translation="MAYEILPSKHVIKYLKKLKEKTLKEQFLTIIYDEIAVRPHSGEQK
                     TGDLSGIWAIGFKYAGTTYRVAYEIKDNAVIPILLCGTHERFL"
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            17247..17585
                     /locus_tag="Q7582_RS16160"
                     /old_locus_tag="Q7582_16095"
     CDS             17247..17585
                     /locus_tag="Q7582_RS16160"
                     /old_locus_tag="Q7582_16095"
                     /inference="COORDINATES: protein motif:HMM:NF020419.4"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotidyl transferase AbiEii/AbiGii toxin
                     family protein"
                     /protein_id="WP_342080287.1"
                     /translation="MKDFYDLYMIPKLERIDEKNLYKSVQGTFKERNNQSVFKHLYDQE
                     MPQLVKDEGLREKWKRYQQENYFAKDISFESTLTSVDSLMQSIVEQEKAERKQNFKRSQ
                     QMNQEMER"
                     /name="nucleotidyl transferase AbiEii/AbiGii toxin family
                     protein"
     gene            17588..18073
                     /gene="ssb"
                     /locus_tag="Q7582_RS16165"
                     /old_locus_tag="Q7582_16100"
     CDS             17588..18073
                     /gene="ssb"
                     /locus_tag="Q7582_RS16165"
                     /old_locus_tag="Q7582_16100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002339775.1"
                     /GO_function="GO:0003697 - single-stranded DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA];
                     GO:0006281 - DNA repair [Evidence IEA]; GO:0006260 - DNA
                     replication [Evidence IEA]; GO:0006351 - DNA-templated
                     transcription [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="single-stranded DNA-binding protein"
                     /protein_id="WP_002296241.1"
                     /translation="MINNVTLVGRLTKDPDLRYTASGTAVATFSLAVNRNFTNQNGNRE
                     ADFINCVIWRKPAETMATLAKKGSLIGVVGRIQTRTYDNQQGQRVYVTEVVADNFQLLE
                     SKAATESRMHADQSSSSPSPTTFEQRDTATPNNNGLNASQNPFGGQSIDISDDDLPF"
                     /name="ssb"
     gene            18439..18699
                     /locus_tag="Q7582_RS16170"
                     /old_locus_tag="Q7582_16105"
     CDS             18439..18699
                     /locus_tag="Q7582_RS16170"
                     /old_locus_tag="Q7582_16105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002339774.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002296240.1"
                     /translation="MNKYVGLLDKIRVIKTQPLLVRFTLQTIHESINCVVADIEIIDKL
                     LIMDDGKYNIAVTGHFNKRNQLVIASMYVRNPDHFTRSMGI"
                     /name="hypothetical protein"
     gene            19140..19346
                     /locus_tag="Q7582_RS16175"
                     /old_locus_tag="Q7582_16110"
     CDS             19140..19346
                     /locus_tag="Q7582_RS16175"
                     /old_locus_tag="Q7582_16110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016853414.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002296239.1"
                     /translation="MRKKFDYWGVPFSELFPNYHAPHTVECDCGERAKCIKSYRLYQCP
                     TCGKKYTLSYGDYILIDEKGKKR"
                     /name="hypothetical protein"
     gene            19346..19597
                     /locus_tag="Q7582_RS16180"
                     /old_locus_tag="Q7582_16115"
     CDS             19346..19597
                     /locus_tag="Q7582_RS16180"
                     /old_locus_tag="Q7582_16115"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002314430.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002296238.1"
                     /translation="MKTQHKLLTVKEVVQILVDKEVISEKVAEALLIPRYWTIETPLVE
                     DAPTMLFEDLVKIAGYELHYQENMETYEIEYWLTKLEN"
                     /name="hypothetical protein"
     gene            19612..20049
                     /locus_tag="Q7582_RS16185"
                     /old_locus_tag="Q7582_16120"
     CDS             19612..20049
                     /locus_tag="Q7582_RS16185"
                     /old_locus_tag="Q7582_16120"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016922517.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002296237.1"
                     /translation="MAQNYYDEFVKLPLDKMAQKMEDMTFLYHETRVPKKHYKEKLSVA
                     VEEMIESGVEMNLIATYYRTLEELKKQNGKWFFQALLCLEVGVKPSTIKPSEYQALELT
                     YAKFAQIKKAKAMASDWLDTFESIEKNGAFYTIESEEKDNE"
                     /name="hypothetical protein"
     gene            20042..20749
                     /locus_tag="Q7582_RS16190"
                     /old_locus_tag="Q7582_16125"
     CDS             20042..20749
                     /locus_tag="Q7582_RS16190"
                     /old_locus_tag="Q7582_16125"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002318326.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_098379831.1"
                     /translation="MNKVVYQLTTEDVSQFLTDKEHLNEVIRRIQKDFSCMEEMKYFIQ
                     RVEEQLYMESETSQTKVTVSHNHLDVYKRRPETVKKGTELLRLETEKYIMNVYLERSEL
                     VENFVSYTICRKHYYSESEYYSIFESMELMEEEMEELNSKNATVDDYYLVFTRFLTCGT
                     ESIVLMGMDYELAVPEAFLREYVEEVDNPGDDWYTTLTDFLDTYTYDDTEEIQNELDRK
                     RMPYQRFERKKGK"
                     /name="hypothetical protein"
     gene            20914..21114
                     /locus_tag="Q7582_RS16195"
                     /old_locus_tag="Q7582_16130"
     CDS             20914..21114
                     /locus_tag="Q7582_RS16195"
                     /old_locus_tag="Q7582_16130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002341525.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002330566.1"
                     /translation="MNKIIPLLFVLFVGEILMRHAAAVHLNFVVFLGILVFCLIFWRFV
                     LALVSLLFKMIAAIFFIGLFR"
                     /name="hypothetical protein"
     gene            21130..21309
                     /locus_tag="Q7582_RS16200"
                     /old_locus_tag="Q7582_16135"
     CDS             21130..21309
                     /locus_tag="Q7582_RS16200"
                     /old_locus_tag="Q7582_16135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002295613.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002305761.1"
                     /translation="MPIAIGNKRLPVTLDEKRQKELQQLKQKYGKSESKIMCIALDLLI
                     AQEKAGFDIPALKK"
                     /name="hypothetical protein"
     gene            21650..21913
                     /locus_tag="Q7582_RS16205"
                     /old_locus_tag="Q7582_16140"
     CDS             21650..21913
                     /locus_tag="Q7582_RS16205"
                     /old_locus_tag="Q7582_16140"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002329851.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002287514.1"
                     /translation="MEMLPIKKWGNSNGLRLPKYIMEYLGIHTEDKVKIIQEEVNGQKR
                     LIIEAANIENELTIEQLFENYTDERNHVTIQNLGEAVGNEKW"
                     /name="hypothetical protein"
     gene            21907..22257
                     /locus_tag="Q7582_RS16210"
                     /old_locus_tag="Q7582_16145"
     CDS             21907..22257
                     /locus_tag="Q7582_RS16210"
                     /old_locus_tag="Q7582_16145"
                     /EC_number="3.1.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016610020.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003723 - RNA binding [Evidence IEA]; GO:0004521 - RNA
                     endonuclease activity [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system PemK/MazF family
                     toxin"
                     /protein_id="WP_002321032.1"
                     /translation="MVRKPRQGDILLLNTAPRSGHEQTGKRPYIVLSHDIIADYSNVVT
                     VAPISSTTRNYPLYVNINSEYEMKTTGKVLLDQLTTIDYEARECIFLEKAHDSLVEELL
                     MKVRTVFQKVSK"
                     /name="type II toxin-antitoxin system PemK/MazF family
                     toxin"
     gene            complement(22281..22895)
                     /locus_tag="Q7582_RS16215"
                     /old_locus_tag="Q7582_16150"
     CDS             complement(22281..22895)
                     /locus_tag="Q7582_RS16215"
                     /old_locus_tag="Q7582_16150"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001261742.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_342080289.1"
                     /translation="MRVAYIRVSSIDQNEQRQIEEMKKFGAERIFIEKQSGATITHRPV
                     FQEALDYVRDQDIFIVEAIDRLGRNYDEIIASVNYLKKKNVKLIITSLPIMAEAIGNPL
                     LDKFIKDLIIQILAMIAEQERTESKRRQAQGIKIAKANGVYKGRPKLYSANAKDPQRRL
                     VYKNIVEDLKKGVAIAKIAKDYNVTRQTVYRIKKDSMVNHE"
                     /name="recombinase family protein"
     gene            23345..24670
                     /locus_tag="Q7582_RS16220"
                     /old_locus_tag="Q7582_16155"
     CDS             23345..24670
                     /locus_tag="Q7582_RS16220"
                     /old_locus_tag="Q7582_16155"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002335330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Y-family DNA polymerase"
                     /protein_id="WP_000969590.1"
                     /translation="MMDYSKEPVNDYFLIDMKSFYASVECIERNLDPLTTELVVMSRAD
                     NTGSGLILASSPEAKKRYGITNVSRPRDLPQPFPKTLHVVPPRMNLYIKRNMQVNNIFR
                     RYVADEDLLIYSIDESILKVTRSLNLFTTEGTRSQRRKKLAQMIQENIKEELGLIATVG
                     VGDNPLLAKLALDNEAKHNEGFVAEWTYENVPEKVWNIPEMTDFWGIGSRMKKRLNQMG
                     IMSIRDLANWNPYTIKNRLGVIGLQLYFHANGIDRTDIAIPPEPTKEKSYGNSQVLPRD
                     YTRRNEIELVVKEMAEQVAIRIRQHNCKTGCVHLHIGTSILETRPGFSHQMKIPITDNT
                     KELQNYCLFLFDKYYEGQEVRHVGITYSKLVYTDSLQLDLFSDPQKQIDEENLDKIIDK
                     IRQKYGFTSIVHASSMLEGARSITRSTLVGGHAGGNGGIKND"
                     /name="Y-family DNA polymerase"
     gene            24663..25013
                     /locus_tag="Q7582_RS16225"
                     /old_locus_tag="Q7582_16160"
     CDS             24663..25013
                     /locus_tag="Q7582_RS16225"
                     /old_locus_tag="Q7582_16160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002359653.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_342080290.1"
                     /translation="MIDYNDRGRLKWAGFYLSDHTEEIDADNEQRANHNLAKEQMTTEE
                     IAEVLNAAVIKNRSVSIQKEERNAEGYYPEDIIGKILGSDELGIYVGKDKIHYDEIRHI
                     EFYQDNKWSRLE"
                     /name="hypothetical protein"
     gene            25010..25189
                     /locus_tag="Q7582_RS16230"
                     /old_locus_tag="Q7582_16165"
     CDS             25010..25189
                     /locus_tag="Q7582_RS16230"
                     /old_locus_tag="Q7582_16165"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001021554.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001021554.1"
                     /translation="MNIIQQYELKYITFDQLSEEIWGYGQRLINEVGVERFSFYVEAAA
                     GYHNFRFYIFPLYI"
                     /name="hypothetical protein"
     gene            25325..25618
                     /locus_tag="Q7582_RS16235"
                     /old_locus_tag="Q7582_16170"
     CDS             25325..25618
                     /locus_tag="Q7582_RS16235"
                     /old_locus_tag="Q7582_16170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002352765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002326890.1"
                     /translation="MSINTFVYSHPINVYIIKNLGITVEQFCELYAYPQGTVASWITRQ
                     RRIKSLPASFIYDLSLASSCNMSDVYEKLLILENEYDQFNSNQKKKKKKHID"
                     /name="hypothetical protein"
     gene            25937..26779
                     /locus_tag="Q7582_RS16240"
                     /old_locus_tag="Q7582_16175"
     CDS             25937..26779
                     /locus_tag="Q7582_RS16240"
                     /old_locus_tag="Q7582_16175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002323027.1"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ParA family protein"
                     /protein_id="WP_002323027.1"
                     /translation="MNANSIVVGNFKGGTGKSTSTQMLGFVNAFYKKRKTLLIDLDPQA
                     NASEVMSFTADNLGNHFYQENGFPKTIWNVLYDGSLDGAVLPLIENLDLIAGNIAMSDY
                     SDFMSAKFPNDKLAQFEYFANILAPLKEEYDEIFIDVPPSLGTIVQSAMYFAEYVAIML
                     QTQPKSIRGAADYIDYMEFFTERYNTQLGIAGIIPFMLDTKTSTESYMYNEAKKLYGDN
                     LINTIVFRSARLIRYDETGITLETKKNGELKKVDANPQNTFISILDELNEHISWFEEE"
                     /name="ParA family protein"
     gene            26782..27336
                     /locus_tag="Q7582_RS16245"
                     /old_locus_tag="Q7582_16180"
     CDS             26782..27336
                     /locus_tag="Q7582_RS16245"
                     /old_locus_tag="Q7582_16180"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002323026.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002323026.1"
                     /translation="MAERQSKLFPNKKARPRTNGMKDMEEFTKSLSISSADNSAPKVNT
                     TEKHSDDNKNLKNPNKSHKGKAGRKAEYKDPRLKKDLNTKISLSTKLRIQRLISRKFDN
                     KSEGDVIDIALDYLVSSFDRDDRDSLYKAYKEDMESMIPIIQEKNEKAKKQGKLTLDIT
                     DEINQQTLKEQKEKWVSAKFE"
                     /name="hypothetical protein"
     ARG             11175..12139
                     /name="vanH-A"
                     /gene="vanH-A"
                     /gene_name="D-lactate dehydrogenase VanH-A"
                     /tool="amrfinderplus"
                     /drug_class="GLYCOPEPTIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             13173..13777
                     /name="vanX-A"
                     /gene="vanX-A"
                     /gene_name="D-Ala-D-Ala dipeptidase VanX-A"
                     /tool="amrfinderplus"
                     /drug_class="GLYCOPEPTIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             8299..9449
                     /name="vanS-A"
                     /gene="vanS-A"
                     /gene_name="vancomycin resistance histidine kinase VanS-A"
                     /tool="amrfinderplus"
                     /drug_class="GLYCOPEPTIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             14209..15116
                     /name="vanY-A"
                     /gene="vanY-A"
                     /gene_name="D-Ala-D-Ala carboxypeptidase VanY-A"
                     /tool="amrfinderplus"
                     /drug_class="GLYCOPEPTIDE"
                     /identity="99.67"
                     /coverage="100.0"
     ARG             11175..12142
                     /name="vanH gene in vanA cluster"
                     /gene="vanH gene in vanA cluster"
                     /gene_name="vanH; glycopeptide resistance gene cluster"
                     /tool="rgi"
                     /drug_class="glycopeptide antibiotic"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             7626..8320
                     /name="vanR gene in vanA cluster"
                     /gene="vanR gene in vanA cluster"
                     /gene_name="glycopeptide resistance gene cluster; vanR"
                     /tool="rgi"
                     /drug_class="glycopeptide antibiotic"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             14209..15119
                     /name="vanY gene in vanA cluster"
                     /gene="vanY gene in vanA cluster"
                     /gene_name="vanY; glycopeptide resistance gene cluster"
                     /tool="rgi"
                     /drug_class="glycopeptide antibiotic"
                     /identity="99.67"
                     /coverage="100.0"
     ARG             15273..15757
                     /name="vanZ gene in vanA cluster"
                     /gene="vanZ gene in vanA cluster"
                     /gene_name="vanZ; glycopeptide resistance gene cluster"
                     /tool="rgi"
                     /drug_class="glycopeptide antibiotic"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             8311..9452
                     /name="vanS gene in vanA cluster"
                     /gene="vanS gene in vanA cluster"
                     /gene_name="vanS; glycopeptide resistance gene cluster"
                     /tool="rgi"
                     /drug_class="glycopeptide antibiotic"
                     /identity="99.74"
                     /coverage="98.96"
     ARG             13173..13780
                     /name="vanX gene in vanA cluster"
                     /gene="vanX gene in vanA cluster"
                     /gene_name="vanX; glycopeptide resistance gene cluster"
                     /tool="rgi"
                     /drug_class="glycopeptide antibiotic"
                     /identity="99.5"
                     /coverage="100.0"
     Typing          650..1056
                     /name="rep_cluster_889"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="95.588"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 attattaaaa attggggata taaagcaaca aatgtttata ttgaaaaata ttataaattt
       61 cctagttttt taattcagaa ttctaaatat tcaaaaatga aagacagctc aaaaatagct
      121 tatatgcttt ttaaaaatga atttcgtaga gctttgcatg aaaaatggat cgacgatgat
      181 ggactattat atttggaatt tacacaagcc gatctaatgg ataaattaaa ttgctatcaa
      241 ggcaaagtaa aaaccatttt aaacgagtta gaaacatata atttgatttc tgtcgtaaaa
      301 ggagaattta acccaaaaac gaaaaaaaat gaaaaaaata aatactattt acttcaacct
      361 gaaataagtg ccgatgatct ttttattcaa aattctttcg atgacgattt aagcgaaact
      421 attgataaat caacctcttc tcggaatgcg gaaatcgcac gtcgagagga aactgctaaa
      481 acccttgata atactggaaa tgcggaaatc gcacgtcgag aaaaaacagc tgaaaccctt
      541 gataacactg gaaatgcgga aatcgcacaa gattattata ttaataaatc tttagacact
      601 aaaagacact taaaagacac tgaaacagac caattacaaa atcaagtttt gctagataac
      661 ttcgttgaaa tcatgaaaga agacagcata aacacatttg taccagaaaa ggtattaagc
      721 ttgataaaaa cattttctaa cacttacgaa gaagcccaac aaactgtcac cacaatacac
      781 aacgcaaaac ataaagccga ggaacttgag aagacggtag ttgtgtatga agaactggaa
      841 tcttatggaa ttgatgctga caaaggatta tatatgactt tactgaaagc ttatcaaaaa
      901 caaaaaactg aaaaagtaaa caatttgcag aatctaattt tcgtttatgt aaaaaattgg
      961 tttgtcgaaa aagctattgc ggcaaagctt gcaaacgaac aaagagaaac atttaacgaa
     1021 ttaccaacag ttagtacgga aaattggtta gagtagttga taaaaagcga tcactataaa
     1081 aatgatcaat tttaaattag aactttttta tgattttaat tttattacaa atgttacaaa
     1141 taaatagtta ttattccgga gtttttagat taaaagttta tgaaaacaat cacaaacgta
     1201 ggttttaaag tcataatcgt tagatatttt agttattttt cattcaaaaa aatagggaac
     1261 tagtgtttgc atatgtgctt ttttgagtta taataattca tgaagagagg taattcactt
     1321 atttccccaa gctgaaaagc ctgatattac ttcttttcag gcagtgctgc taatattcaa
     1381 ttacactttt ttgtatattt ttagttgttt taaatttaat tgtctgatat gcttgtgatg
     1441 aattgatttt cgttctgcac ttttggacga taaattgtga taattgaaaa tacaaaaaaa
     1501 agaaaggccc ctgtaaggct cgggagactg gtaatctccg tcagtgtcct acaggaaagc
     1561 attaagatga cgccttaatg cgtgcccttc agtgttacgg tattacccgc aacggacggt
     1621 tctgttgcaa agttttaaat aaagaataaa atcccttacg gtatctatga tttaagctgg
     1681 gattcccaat aataccttga tttcagtaca gaccgaaaac ccgaagagag tgccttcttt
     1741 tcgggttttc ttatataatc ctcgaatggc ttccatgcct ttaatcgtgg tagaggcagt
     1801 gcgtaaactt cgatataatt tattgcgtct ctttactgga cgatggtctt gttcaatcaa
     1861 attattcagg tatttaatgg tacgatgttc tgtcccttga taaaagccgt attcttttag
     1921 tttcttaaag gcacttgtaa tagagggggc tttatctgtg actacaacct tcggttcatc
     1981 aaactgcttc actaaccgct taagaaaagc ataggctgct tgtgtgtccc gttttttacg
     2041 taaccaaata tccaaggtta aaccatctgc accgatggct cgatacaaat aatgccattt
     2101 tcctttaatt ttgatgtacg tttcatccat tttccatgaa taaaaggatt ttttattttt
     2161 ctttttccaa atttgataga gtagtttgcc atattcttgc acccaacgat aaatcgtcgt
     2221 atgagaaacg ttaatgccac gatcatataa gatttcttga acttcacgat agctaaggtt
     2281 ataacgaaga tagtagccca cggctacaat aatcacatcc tgctgaaatt gctttccttt
     2341 aaaatgattc atcgtcattc ctcctgctat ctttttctat tattctacct tatttgatag
     2401 tagatttaaa actttgcaac agaacccgta taatgaactt gagttacgga actaggtgaa
     2461 gtagtttccg taaaggtcga gagtgcgtca acactgctcg actatttttt tactcttttt
     2521 tctcattttc tttgattata gcactcctct agaaaaaata aaaagacctc agggaatttc
     2581 attccccgaa ccccttgagc ctcctcctgc cgaaatagaa tggcgctgcc agcatttatt
     2641 tcgttcagct atcggctaca caatctaaca cgaccgttcc gctaccagtc gccttacagg
     2701 ctccattttc gctcctctaa cgtgtttcac cgattgtgcc gataactaaa cgaaataaac
     2761 gctaaaaccg ctcagaacgc aaaatatgcc attttagagc tattgtagaa aatatagttt
     2821 gaaatgcaat tttcttcttt cagcttttta tttcccactt gtaaatcggt agatggtggc
     2881 tccttttcca gttccataat gtggatttgc atctgcatgt agtgatgaaa cacctagctg
     2941 cattctcata ccatctgacg aagatgttgt accgtcgccc caatagaaag gcaattgtaa
     3001 tttatgatga aagtttacta atatggcttg ggctttattc atggcatctt catacatgcg
     3061 ccattgagat acattggcta gttgcttata tgtaagtccg ggtgtggctt cggccatctt
     3121 gctcaagcca atattcattc ccattcctaa aagggcagcc atgataatga ttgtttcttc
     3181 cttatctggt tttcgattat tggaagcatg agtgaattgc tcatgaaatc ctgttatatg
     3241 ggccacatcc atgagtaaat cagttaattt tattcttggt agcatctgat aaaggcttgc
     3301 actaaatttt tttgcttctt ctggaacatc tttttctaag cgtgcaagtg atagctttcc
     3361 tttttcaaga gaaaccccat ctaacttatt ggaattggca gctaaccact ttaacctttc
     3421 attaaagctg ctggttctct ccgttatata atcttcgaat gataaactaa ctgataatct
     3481 cgtattcccc ttcgattgat tccatgtatc ttccgaaaac aaatattcct caaaatccct
     3541 atattgtctg ctgccaacaa tggaaacatc tcctgcccga acatgctccc gaagttctgt
     3601 taaaacagcc atttcatagt aatgacgatt aattgttgta ccatcatcct cgtataaatg
     3661 tcttttccat cgttttgaaa taaaatccac aggtgagtca tcaggcactt ttcgctttcc
     3721 agattcgttc attcctcgga taatctcaac agcttgtaaa agtggctcat ttgcctttgt
     3781 agaatgaaat tccaatactc ttaatagcgt tggcgtatat tttcttagtg aataaaaccg
     3841 tttttgcagt aagtctaaat aatcatagtc ggcaggacgt gcaagttcct gagcctcttc
     3901 tactgaagag acaaaggtat tccattcaat aaccgattct aaaaccttaa aaacgtctaa
     3961 tttttcctct cttgctttaa ttaatgcttg tccgatgttc gtaaagtgta taactttctc
     4021 atttagcttt ttaccgtttt gtttctggat ttcctcttga gccttacgac cttttgataa
     4081 caaactaagt atttgcctat catgaatttc aaacgcttta tccgttagct cctgagtaag
     4141 ttgtaataaa tagatggtta atatcgaata acgtttattt tcttgaaagt cacggaatgc
     4201 atacggctcg tatcttgagc ctaagcgaga cagctgcaac aggcggttac ggtgcaaatg
     4261 actaatttgc actgtttcta aatccattcc tcgtatgtat tcgagtcgtt ctattatttt
     4321 tagaaaagtt tcgggtgaag gatgacccgg tggctctttt aaccaaccca atatcgtttt
     4381 attggattcg gatggatgct gcgaggtaat aatcccttca agcttttctt tttgctcatt
     4441 tgttagagat ttactaaccg tattaaatag cttcttttca gccattgccc ttgcttccca
     4501 caccattctt tcaagtgtag tgatagcagg cagtataatt ttgttttttc ttagaaaatc
     4561 tatgcattca tgcagtagat gaatggcatc accattttcc aaagctaatt gatgaaggta
     4621 cttaaatgtc attcgatatt cactcagggt aaaagttaca aagtcgtatt cacttcgaat
     4681 ttctttcaaa tgatcccaaa gtgtattttc cctttgagga taatgatcaa gcgaggatgg
     4741 actaacacca atctgtttcg atatatattg tatgaccgaa tctgggatgc ttttgatatg
     4801 agtgtatggc caaccgggat accgaagaac agctaattga acagcaaatc ctaaacggtt
     4861 ttcttccctc cttcgcttat taactatttc taaatcccgt ttggaaaaag tgaagtaggt
     4921 ccccagtatc cattcatctt cagggatttg cataaaagcc tgtctctgtt ccggtgtaag
     4981 caattctcta cctctcgcaa ttttcattca gtatcattcc atttctgtat tttcaattta
     5041 ttagttcaat tatatatcaa tagagtgtac tctattgata caaatgtagt agactgataa
     5101 aatcatagtt aagagcgtct cataagactt gtctcaaaaa tgaggtgata ttttgcggaa
     5161 aatcggttat attcgtgtca gttcgactaa ccagaatcct tcaagacaat ttcagcagtt
     5221 gaacgagatc ggaatggata ttatatatga agagaaagtt tcaggagcaa caaaggatcg
     5281 cgagcaactt caaaaagtgt tagacgattt acaggaagat gacatcattt atgttacaga
     5341 cttaactcga atcactcgta gtacacaaga tctatttgaa ttaatcgata acatacgaga
     5401 taaaaaggca agtttaaaat cactaaaaga tacatggctt gatttatcag aagataatcc
     5461 atacagccaa ttcttaatta ctgtaatggc tggtgttaac caattagagc gagatcttat
     5521 tcggatgaga caacgtgaag ggattgaatt ggctaagaaa gaaggaaagt ttaaaggtcg
     5581 attaaagaag tatcataaaa atcacgcagg aatgaattat gcggtaaagc tatataaaga
     5641 aggaaatatg actgtaaatc aaatttgtga aattactaat gtatctaggg cttcattata
     5701 caggaaatta tcagaagtga ataattagcc attctgtatt ccgctaatgg gcaatatttt
     5761 taaagaagaa aaggaaacta taaaatatta acagcctcct agcgatgccg aaaagccctt
     5821 tgataaaaaa agaatcatca tcttaagaaa ttcttagtca cctgaataat tcatactttt
     5881 aattaaaacc atgtgaaact gcctcacggc agcttacaat tactttttca tcttcacccg
     5941 ttaagtgatg aaaaaagaac ccctttctgc tatggttaaa gtgactaaac caaccaaaag
     6001 aaaggagttc ttttcatgac tagcttacac aaaaaccaag taaaattcaa ttcaaatatc
     6061 actatttctc atacaggtgg tcaattatcg agtgattcgg gtctcgtcct agtgaaagag
     6121 ctgatgaaca tctttggttt ttctgaactg gctaagcaac acattcacat tgaagacgaa
     6181 cgagcgtatt ttactcatga caacttatcc atacttgagc agttcattat gcaattaatt
     6241 gctggttact cagctgattc tgcagctaat ctcctgagac aagatcctgt gtttaaagct
     6301 gttttagata ggaaagaact cgcttctcaa tcttcacttt cccgattttt agatcgacta
     6361 tctgaggaga atatccatga acttcaagct ttgaaccaag aacttatcga taaagcacgc
     6421 ctcatccgta atgatacgga attaatcatt gatttagatt cgacccattc agatacattt
     6481 ggtcaccaag aacaaacgaa ttataataca cactaccaaa cctatggtta ccatccattg
     6541 gtagcttttg acggattgac tggtgacttc ttaaaagctg aactacgttc aggaaatcaa
     6601 tatacatcaa aaggcgtaaa ggagtttctc acacctttat tagagcacta taatcactct
     6661 ctaccaaaca ctgacatctt ggttcgtgga gacagcgggt tcgctacacc tggtgtgtat
     6721 gattcgtgtg aatcaaaaaa gagtcattat gttattcgac tgaagaataa tcgtagacta
     6781 ggtcaaatag ctgagaaatc agtactttat ggcgataatc aaaagtggga agaacgagaa
     6841 gttcagtact tctcgaccac ttatcaagca caatcctggt cacaaagtcg tcgcgtgtgt
     6901 atacgctcaa cacgtgaagc gggcgaacta ctctttcgac atgaatttat cgtgacgaat
     6961 ctatcagaaa atgtttctcc tgataccatc ttttctatct atgccaaacg tggcacaatg
     7021 gagaacttca ttaaagaagc gaaagctggc ttttactttg acaaaacaga cagtcctcgc
     7081 tttttggaga atcatgtccg aatgatgctc agcttgatag cttacaactt agtcaacttc
     7141 ttaagaacga ttggctttga agaagtccaa aagggaatga ccattcattc tattcgattg
     7201 aagtttctga aagttgctgg gaaattagtc caaacgggta gacgagtcta tctcaaatta
     7261 tctagttatc atgtgtatca gaatgaattc tacagggtct ttgctcgcct gaggcgagcc
     7321 agtcaatgga tctaatccaa caatctaacg atttttttac tgggaagtta tccagggaga
     7381 agtatgctca aaatgcctta cacccaaaat ttattcctca atatttttga acagtgaatg
     7441 tttgaagtaa ctttttagtc aaaatcagtt gatagggata ttagtgatac atatttcaat
     7501 aaaatgtgcc aaagaattaa agctatgaat tattcaggag tcatttatta tgtaaatgct
     7561 tataaattcg gccctataat ctgataaatt attaagggca aacttatgtg aaagggtgat
     7621 aactatgagc gataaaatac ttattgtgga tgatgaacat gaaattgccg atttggttga
     7681 attatactta aaaaacgaga attatacggt tttcaaatac tataccgcca aagaagcatt
     7741 ggaatgtata gacaagtctg agattgacct tgccatattg gacatcatgc ttcccggcac
     7801 aagcggcctt actatctgtc aaaaaataag ggacaagcac acctatccga ttatcatgct
     7861 gaccgggaaa gatacagagg tagataaaat tacagggtta acaatcggcg cggatgatta
     7921 tataacgaag ccctttcgcc cactggagtt aattgctcgg gtaaaggccc agttgcgccg
     7981 atacaaaaaa ttcagtggag taaaggagca gaacgaaaat gttatcgtcc actccggcct
     8041 tgtcattaat gttaacaccc atgagtgtta tctgaacgag aagcagttat cccttactcc
     8101 caccgagttt tcaatactgc gaatcctctg tgaaaacaag gggaatgtgg ttagctccga
     8161 gctgctattt catgagatat ggggcgacga atatttcagc aagagcaaca acaccatcac
     8221 cgtgcatatc cggcatttgc gcgaaaaaat gaacgacacc attgataatc cgaaatatat
     8281 aaaaacggta tggggggttg gttataaaat tgaaaaataa aaaaaacgac tattccaaac
     8341 tagaacgaaa actttacatg tatatcgttg caattgttgt ggtagcaatt gtattcgtgt
     8401 tgtatattcg ttcaatgatc cgagggaaac ttggggattg gatcttaagt attttggaaa
     8461 acaaatatga cttaaatcac ctggacgcga tgaaattata tcaatattcc atacggaaca
     8521 atatagatat ctttatttat gtggcgattg tcattagtat tcttattcta tgtcgcgtca
     8581 tgctttcaaa attcgcaaaa tactttgacg agataaatac cggcattgat gtacttattc
     8641 agaacgaaga taaacaaatt gagctttctg cggaaatgga tgttatggaa caaaagctca
     8701 acacattaaa acggactctg gaaaagcgag agcaggatgc aaagctggcc gaacaaagaa
     8761 aaaatgacgt tgttatgtac ttggcgcacg atattaaaac gccccttaca tccattatcg
     8821 gttatttgag cctgcttgac gaggctccag acatgccggt agatcaaaag gcaaagtatg
     8881 tgcatatcac gttggacaaa gcgtatcgac tcgaacagct aatcgacgag ttttttgaga
     8941 ttacacggta taacctacaa acgataacgc taacaaaaac gcacatagac ctatactata
     9001 tgctggtgca gatgaccgat gaattttatc ctcagctttc cgcacatgga aaacaggcgg
     9061 ttattcacgc ccccgaggat ctgaccgtgt ccggcgaccc tgataaactc gcgagagtct
     9121 ttaacaacat tttgaaaaac gccgctgcat acagtgagga taacagcatc attgacatta
     9181 ccgcgggcct ctccggggat gtggtgtcaa tcgaattcaa gaacactgga agcatcccaa
     9241 aagataagct agctgccata tttgaaaagt tctataggct ggacaatgct cgttcttccg
     9301 atacgggtgg cgcgggactt ggattggcga ttgcaaaaga aattattgtt cagcatggag
     9361 ggcagattta cgcggaaagc aatgataact atacgacgtt tagggtagag cttccagcga
     9421 tgccagactt ggttgataaa aggaggtcct aagagatgta tataattttg gctctttgtc
     9481 aaatgatgtt ggtaaagaga aatcttagaa taattggaga tcaagtggat cagttcctct
     9541 tgatcttttt tagttgaaaa tcaatgcgtt gccatgacga atcatgatgc gcaatttgaa
     9601 attataaaag ctacgaaagc catatgcatt tcgttttaac actttgatat ggttgttcag
     9661 acattcaagt gggccatttg aataactttg ttgtaaagca tttttgattt gtggcagaaa
     9721 tttctggaac gttctcaagg tcgtctgata gccttcggga agcatgatat tattggtaag
     9781 tagttcttca aacgatacgt agtctcgttc ctttacagcg taaagaaagt cttgatataa
     9841 ctgatagcct acacgcaaag cagggctccc tttcagtaag cgatccacaa tatcggtctc
     9901 tgttaaatga gctttgaagc caggtcgcca aaggcgtcga gtataatcaa gcttgcgttc
     9961 atctttttga agaagtttcc agtatctttt taattgctta cctaattgat agtgtttttg
    10021 ttctttgctt tttaatagtt ggttcgtttc tttgattcga tgattgcgaa aggtacgacc
    10081 aatatgttgg acgatgtgaa accggtcaat aatcagctgt gcttttggaa acagcttttt
    10141 aacgagcgat acataaggag cgtacatatc aatcacgatc cattcgaccg cttcacgaat
    10201 ttctcgtgaa aaatgactaa aataacgttt taaaaaaggc agttgtcggt tctcgacaat
    10261 gtccaataag cgctgtgttt gtccatccat catgatgaaa ctcatagcac ctgaaacacc
    10321 ccgaactgat ttgaattcat caaaacaaag taccttaggt aacggtgtcc gaaaaggatt
    10381 caacggacga taaaatcgct tcataatacg gtaaacagaa gagaccgata gatttttctg
    10441 agcggcgatc tctgtcattg aggtattttt tttcagacga gtcacgacag accagcggac
    10501 tttctcactg atgaaacaat gttttttcgc aacagaagta tctgcgacaa aggtccgctg
    10561 acaagctttg catttgaagc gttgcttttt caattcgagg taggtacggt attcagaaac
    10621 atcgttcatt aacaaccgga cggttgttgt accccaacgc acaatatctg aagcaatctg
    10681 gtgtttacag tggatgcatt cttgggctgt ataaatcaag tttccacgat aaatatgaca
    10741 gatttgccct ttgtattttt cttttgtgag acaattttcg ttaaaagtaa ctgataagtc
    10801 tagaatatct aatgtttctt tgataaggtg agtgtaagac atcttgattc ctccttttgg
    10861 gttggttcgc caaattaatt ctaaaggatt tcaaggtgtc ttttctatat gttttggaaa
    10921 ataaaaaaga tgctggtgtc atccaccaac atcaaaaagt atagagccat aattttttag
    10981 gaaaatctca aggttatctt tactttttct taggaaatta acaatttaat attaagaaac
    11041 ggctcgttct tacacggtag acttaatacc gtaagaacga gccgttttcg ttcttcagag
    11101 aaagatttga caagattacc attggcatcc ccgttttatt tggtgccttt cacagaaagg
    11161 gttggtctta attatgaata acatcggcat tactgtttat ggatgtgagc aggatgaggc
    11221 agatgcattc catgctcttt cgcctcgctt tggcgttatg gcaacgataa ttaacgccaa
    11281 cgtgtcggaa tccaacgcca aatccgcgcc tttcaatcaa tgtatcagtg tgggacataa
    11341 atcagagatt tccgcctcta ttcttcttgc gctgaagaga gccggtgtga aatatatttc
    11401 tacccgaagc atcggctgca atcatataga tacaactgct gctaagagaa tgggcatcac
    11461 tgtcgacaat gtggcgtact cgccggatag cgttgccgat tatactatga tgctaattct
    11521 tatggcagta cgcaacgtaa aatcgattgt gcgctctgtg gaaaaacatg atttcaggtt
    11581 ggacagcgac cgtggcaagg tactcagcga catgacagtt ggtgtggtgg gaacgggcca
    11641 gataggcaaa gcggttattg agcggctgcg aggatttgga tgtaaagtgt tggcttatag
    11701 tcgcagccga agtatagagg taaactatgt accgtttgat gagttgctgc aaaatagcga
    11761 tatcgttacg cttcatgtgc cgctcaatac ggatacgcac tatattatca gccacgaaca
    11821 aatacagaga atgaagcaag gagcatttct tatcaatact gggcgcggtc cacttgtaga
    11881 tacctatgag ttggttaaag cattagaaaa cgggaaactg ggcggtgccg cattggatgt
    11941 attggaagga gaggaagagt ttttctactc tgattgcacc caaaaaccaa ttgataatca
    12001 atttttactt aaacttcaaa gaatgcctaa cgtgataatc acaccgcata cggcctatta
    12061 taccgagcaa gcgttgcgtg ataccgttga aaaaaccatt aaaaactgtt tggattttga
    12121 aaggagacag gagcatgaat agaataaaag ttgcaatact gtttgggggt tgctcagagg
    12181 agcatgacgt atcggtaaaa tctgcaatag agatagccgc taacattaat aaagaaaaat
    12241 acgagccgtt atacattgga attacgaaat ctggtgtatg gaaaatgtgc gaaaaacctt
    12301 gcgcggaatg ggaaaacgac aattgctatt cagctgtact ctcgccggat aaaaaaatgc
    12361 acggattact tgttaaaaag aaccatgaat atgaaatcaa ccatgttgat gtagcatttt
    12421 cagctttgca tggcaagtca ggtgaagatg gatccataca aggtctgttt gaattgtccg
    12481 gtatcccttt tgtaggctgc gatattcaaa gctcagcaat ttgtatggac aaatcgttga
    12541 catacatcgt tgcgaaaaat gctgggatag ctactcccgc cttttgggtt attaataaag
    12601 atgataggcc ggtggcagct acgtttacct atcctgtttt tgttaagccg gcgcgttcag
    12661 gctcatcctt cggtgtgaaa aaagtcaata gcgcggacga attggactac gcaattgaat
    12721 cggcaagaca atatgacagc aaaatcttaa ttgagcaggc tgtttcgggc tgtgaggtcg
    12781 gttgtgcggt attgggaaac agtgccgcgt tagctgttgg cgaggtggac caaatcaggc
    12841 tgcagtacgg aatctttcgt attcatcagg aagtcgagcc ggaaaaaggc tctgaaaacg
    12901 cagttataac cgttcccgca gacctttcag cagaggagcg aggacggata caggaaacgg
    12961 caaaaaaaat atataaagcg ctcggctgta gaggtctagc ccgtgtggat atgtttttac
    13021 aagataacgg ccgcattgta ctgaacgaag tcaatactct gcccggtttc acgtcataca
    13081 gtcgttatcc ccgtatgatg gccgctgcag gtattgcact tcccgaactg attgaccgct
    13141 tgatcgtatt agcgttaaag gggtgataag catggaaata ggatttactt ttttagatga
    13201 aatagtacac ggtgttcgtt gggacgctaa atatgccact tgggataatt tcaccggaaa
    13261 accggttgac ggttatgaag taaatcgcat tgtagggaca tacgagttgg ctgaatcgct
    13321 tttgaaggca aaagaactgg ctgctaccca agggtacgga ttgcttctat gggacggtta
    13381 ccgtcctaat cgtgctgtaa actgttttat gcaatgggct gcacagccgg aaaataacct
    13441 gacaaaggaa agttattatc ccaatattga ccgaactgag atgatttcaa aaggatacgt
    13501 ggcttcaaaa tcaagccata gccgcggcag tgccattgat cttacgcttt atcgattaga
    13561 cacgggtgag cttgtaccaa tggggagccg atttgatttt atggatgaac gctctcatca
    13621 tgcggcaaat ggaatatcat gcaatgaagc gcaaaatcgc agacgtttgc gctccatcat
    13681 ggaaaacagt gggtttgaag catatagcct cgaatggtgg cactatgtat taagagacga
    13741 accatacccc aatagctatt ttgatttccc cgttaaataa acttttaacc gttgcacgga
    13801 caaactatat aagctaactc tttcggcagg aaacccgacg tatgtaactg gttcttaggg
    13861 aatttatata tagtagatag tattgaagat gtaaggcaga gcgatattgc ggtcattatc
    13921 tgcgtgcgct gcggcaagat agcctgataa taagactgat cgcatagagg ggtggtattt
    13981 cacaccgccc attgtcaaca ggcagttcag cctcgttaaa ttcagcatgg gtatcactta
    14041 tgaaaattca tctacattgg tgataatagt aaatccagta gggcgaaata attgactgta
    14101 atttacgggg caaaacggca caatctcaaa cgagattgtg ccgtttaagg ggaagattct
    14161 agaaatattt catacttcca actatatagt taaggaggag actgaaaatg aagaagttgt
    14221 tttttttatt gttattgtta ttcttaatat acttaggtta tgactacgtt aatgaagcac
    14281 tgttttctca ggaaaaagtc gaatttcaaa attatgatca aaatcccaaa gaacatttag
    14341 aaaatagtgg gacttctgaa aatacccaag agaaaacaat tacagaagaa caggtttatc
    14401 aaggaaatct gctattaatc aatagtaaat atcctgttcg ccaagaaagt gtgaagtcag
    14461 atatcgtgaa tttatctaaa catgacgaat taataaatgg atacgggttg cttgatagta
    14521 atatttatat gtcaaaagaa atagcacaaa aattttcaga gatggtcaat gatgctgtaa
    14581 agggtggcgt tagtcatttt attattaata gtggctatcg agactttgat gagcaaagtg
    14641 tgctttacca agaaatgggg gctgagtatg ccttaccagc aggttatagt gagcataatt
    14701 caggtttatc actagatgta ggatcaagct tgacgaaaat ggaacgagcc cctgaaggaa
    14761 agtggataga agaaaatgct tggaaatacg ggttcatttt acgttatcca gaggacaaaa
    14821 cagagttaac aggaattcaa tatgaactat ggcatattcg ctatgttggt ttaccacata
    14881 gtgcgattat gaaagaaaag aatttcgttc tcgaggaata tatggattac ctaaaagaag
    14941 aaaaaaccat ttctgttagt gtaaatgggg aaaaatatga gatcttttat tatcctgtta
    15001 ctaaaaatac caccattcat gtgccgacta atcttcgtta tgagatatca ggaaacaata
    15061 tagacggtgt aattgtgaca gtgtttcccg gatcaacaca tactaattca aggaggtaag
    15121 gatggcggaa tgaaaccaac gaaattaatg aacagcatta ttgtactagc acttttgggg
    15181 taacgttagc tttttaattt aaaacccacg ttaactagga cattgctata ctaatgatac
    15241 aacttaaaca aaagaattag aggaaattat attgggaaaa atattatcta gaggattgct
    15301 agctttatat ttagtgacac taatctggtt agtgttattc aaattacaat acaatatttt
    15361 atcagtattt aattatcatc aaagaagtct taacttgact ccatttactg ctactgggaa
    15421 tttcagagag atgatagata atgttataat ctttattcca tttggcttgc ttttgaatgt
    15481 caattttaaa gaaatcggat ttttacctaa gtttgctttt gtactggttt taagtcttac
    15541 ttttgaaata attcaattta tcttcgctat tggagcgaca gacataacag atgtaattac
    15601 aaatactgtt ggaggctttc ttggactgaa attatatggt ttaagcaata agcatatgaa
    15661 tcaaaaaaaa ttagacagag ttattatttt tgtaggtata cttttgctcg tattattgct
    15721 cgtttaccgt acccatttaa gaataaatta cgtgtaagat gtctaaatca agcaatctga
    15781 tctttcatac acataaagat attgaatgaa ttggattaga tggaaaacgg gatgtgggga
    15841 aactcgcccg taggtgtgaa gtgaggggaa aaccggtgat aaagtaaaaa gcttacctaa
    15901 cactatagta acaaagaaag cccaattatc aattttagtg ctgaggaatt ggtctcttta
    15961 ataaatttcc ttaacgttgt aaatccgcat tttcctgacg gtacccccaa actaagattt
    16021 catagataga ttttctgata actttaaaaa acacgaatag cggaaaggat gtcttcattc
    16081 gctaaagagt aataaactac ttttccatct tgacgtgatt ttgccattcc atgttttttt
    16141 aaaaaacgta aatggtgtga cgttgtagcg acactagcag taagtatttc tgctaaatca
    16201 cagacgcaca tttccttata ggtttctaaa gcatagaaaa ttttaattct agaaaaatcg
    16261 ctgaaacatt tccctaacac aagtaagttt gaaaaatctt tttgatccaa tttatttttt
    16321 attccattta ctttttcttt atgtacgaca gtcacttggc aaactttttt cattcatctc
    16381 acctcacatt caaacgatta tttgaatgaa gtatacctat ttgatcactc ttttgtcaat
    16441 ctaccttaat tccaatacac tattataagc aatttcatgt attgaagtaa acttacttgc
    16501 aagtgcgttt ttgattccaa gttaaaaaca tattattatt ctacataatt tcctaatcaa
    16561 ataaaactcc tttgaaaatt gttctaaagg agttttatta ttttgtattt ctactaaaaa
    16621 tagcgtacaa tgtaattact aagtaattac gaaatgtaaa ataatggagg aaataatatg
    16681 attacaaaaa caagaaaaca aggaaattct attatgttaa cggtccctaa agaattcgat
    16741 gtgcccaatg gtgttgaagt agaagctaag cttgtagaga atggtatcct ttatgagttt
    16801 gtagagccta aaaaagaatt ttttgatttt agtgaagata ttttggctga tattctttca
    16861 gaaggttata gcaaacaaga gatcttaaaa gaatttagaa atagaaaaaa tgcgttaact
    16921 tctgcattta aatctattgc tgaagatact gttgcaaatt ctaaaccgat gacaaaagag
    16981 gagttggcag cagaaattgg cttatgagat tctaccttct aaacacgtaa taaagtatct
    17041 aaaaaaatta aaagagaaaa cattaaaaga acaattttta acgataattt atgatgagat
    17101 agcagttcgt cctcattcgg gagaacaaaa aacgggtgat ttatcaggaa tttgggctat
    17161 tggattcaag tatgcaggta cgacatatcg cgttgcatat gaaattaaag ataatgcagt
    17221 gatacctatc ttactatgtg gaacgcatga aagattttta tgacctgtat atgattccga
    17281 aattagaacg tatcgatgag aaaaatttgt ataagagtgt tcaaggaaca ttcaaggaaa
    17341 gaaataatca atcggtgttt aagcatttgt atgatcagga aatgcctcaa ttggtgaaag
    17401 atgagggctt gagagaaaag tggaaaagat accaacaaga aaactatttt gccaaagaca
    17461 tttctttcga atctacacta acttccgttg attccctgat gcaatcaatt gtagagcaag
    17521 agaaggcaga acgaaaacaa aattttaaga gatcacaaca aatgaatcaa gaaatggaga
    17581 gataaagatg atcaataatg taactttagt agggcgatta actaaagatc cagatttacg
    17641 ttataccgca agtggcacag cagtggcgac tttttcccta gccgttaatc gtaatttcac
    17701 gaatcaaaac ggcaatcgag aagctgattt tatcaattgc gtgatttggc gcaaaccagc
    17761 agaaacgatg gcgacattag ctaaaaaagg cagcttgatc ggcgttgtcg gacgaattca
    17821 aacacggact tatgacaacc agcaaggaca acgtgtgtat gtgacagaag ttgtggccga
    17881 taacttccaa ctattagaaa gtaaagcagc gacagaaagc cgtatgcacg ctgatcaatc
    17941 gtccagcagt ccaagcccta ccacctttga acaacgggat acagcgacgc ctaacaacaa
    18001 tggattgaac gcttcacaga atccatttgg tggacaatca atcgatatta gcgatgatga
    18061 tctaccgttc taagtagcat tttctattgg ttgcatttgc tacggtttat gttataattt
    18121 agacaacaaa aagaattttc aatctataac caaaaaccac tagctggcgg gctagtggct
    18181 ttcttttacg tttctattat aagaattaac gggtaggctt actgtctttc ttggcaaatt
    18241 tacaatcaag ccatttgcag atatagtgcg cggctacttc tgccatgatt gcaaaaacaa
    18301 aatcaaaaag aattttcaaa cctataacct cctccccttg ccagattagg ccggggtagc
    18361 agacagcaag actattatag cataattgaa atatccaaat gattggattt ttgctataat
    18421 tttagcgagg tgattgtgat gaacaaatat gttggtttgc ttgataaaat ccgagtaata
    18481 aaaacgcaac cgttattggt tcgctttact ttacaaacga ttcatgaatc gattaattgt
    18541 gtagttgcag atattgaaat tatcgataaa ttgctaatta tggatgatgg aaaatacaat
    18601 attgccgtca caggtcactt caataaacga aatcagctag ttattgctag catgtatgtt
    18661 agaaatcccg atcattttac gcgatcgatg ggcatataaa taaaagaaga gttgtagtcc
    18721 taaatgagga ttgcagctct ttttgtttta catagaaaca ggaaaagacc tttttaggaa
    18781 gacacaagtg ccttctcaat tgaaaaacct ttctctcact ccaaccgcca ccgccgttcg
    18841 agaagaaagg aagtgaacgc tgcacgttca ctaagatatg gtgtcttgca aagcaagaca
    18901 aaatagacaa aacttcctct caccaaaagg ttcgttcctg ttcgttatct ctttattgat
    18961 ttgccagacc ggcaacaagt tgccttttat caccaaaaag cgacaaggac aagggtaaat
    19021 ggcacgctgc gcgcccttgt ccttgtcgct tttcgttgat ttattctggc caacaaatca
    19081 ataaagaaag aactaacgaa aggaagtaaa acctttccta agaggaggca gaatcaaaca
    19141 tgcgaaagaa atttgattat tggggtgttc ccttcagcga attattccca aactatcatg
    19201 caccacatac tgttgaatgc gattgtggag aaagagcgaa atgtatcaaa agctatcgtt
    19261 tgtatcaatg tccaacatgc gggaaaaaat ataccttgtc ttatggcgat tacattttga
    19321 ttgatgagaa aggaaagaaa cgctgatgaa aacacaacac aaattattga ctgtaaaaga
    19381 agtcgttcaa attttggtgg acaaagaagt catttctgaa aaagtagcag aagctttact
    19441 tattccgcgg tactggacga tagaaacccc tttagtagag gatgcaccga ctatgctatt
    19501 tgaagaccta gtgaagattg caggatatga actgcattat caagaaaaca tggaaactta
    19561 tgaaatcgaa tattggttaa ccaaattaga gaactaaaaa ggagaaaaaa tatggctcaa
    19621 aattactatg acgaatttgt caaattacct ttggataaaa tggcacaaaa aatggaggat
    19681 atgacgttcc tataccatga aacacgtgta cccaaaaaac attacaagga aaaattgtca
    19741 gtcgcagtgg aagaaatgat tgaatcaggt gtcgaaatga atctcattgc gacgtactat
    19801 cgaacactgg aagaactgaa aaaacaaaat ggaaaatggt ttttccaagc cttactatgc
    19861 ttggaagtag gtgtcaaacc aagcactatc aaaccttccg aatatcaagc cttagaactg
    19921 acttatgcaa aattcgcaca gattaagaaa gctaaagcaa tggctagcga ctggctagat
    19981 acttttgaaa gtatcgaaaa aaatggtgca ttttatacga ttgaatcgga ggagaaagat
    20041 aatgaataag gtggtttatc agctaacaac agaagatgtt tcgcaatttt taacagacaa
    20101 agaacacttg aatgaagtaa tcagacggat tcaaaaagac tttagttgta tggaagaaat
    20161 gaagtacttt attcaaagag tggaagaaca gttgtatatg gaaagcgaaa caagtcaaac
    20221 gaaggtcaca gtcagccata atcatttaga cgtgtataaa cgtcgtcctg aaacggtaaa
    20281 aaaaggaaca gagcttctac gactagaaac agaaaaatac atcatgaatg tgtacctaga
    20341 aaggagtgag ctggtcgaaa actttgtcag ctacacgatt tgtaggaaac actattactc
    20401 agaatcagaa tattattcaa ttttcgagag catggaatta atggaagaag aaatggaaga
    20461 gctaaacagc aaaaatgcga cggtagacga ttattacctt gtatttacta ggtttttgac
    20521 gtgtgggacg gaatctatcg tgttaatggg aatggattat gaactcgctg tacccgaagc
    20581 atttttgagg gaatatgtag aagaagtaga taacccaggc gacgactggt acacgacttt
    20641 aactgatttt ttagacacct acacttacga cgatacagaa gaaatccaaa atgaacttga
    20701 ccgtaaacga atgccatatc aacgatttga aaggaaaaaa ggtaaataac catttatacc
    20761 gaaaagtgag gatgtgtgaa ataagaacaa aaaaccttga aattaaggga atggttctta
    20821 tttcgcacca atcgctccaa ccgcccccgc cgcttaggtg gtgcgaaata agcgggcaaa
    20881 gcccgataac ctaagagaaa gaaggagatc catatgaata aaatcattcc tctattgttc
    20941 gtactgtttg ttggcgagat acttatgcgt catgctgcag ctgtacattt aaacttcgta
    21001 gtattcttag gaatactggt attttgtttg atcttttggc gatttgtatt agcccttgtg
    21061 agtctactat tcaagatgat tgcagccata tttttcatag ggttatttcg atgaaaggag
    21121 agagtactaa tgccaattgc aataggaaat aaacggttac ccgtgacatt agatgaaaag
    21181 agacaaaaag aattgcagca actaaagcag aagtacggaa aaagtgaatc taagattatg
    21241 tgtattgcgt tagatctatt gatcgcgcaa gaaaaagcag gatttgatat accagcacta
    21301 aaaaagtgac gtcacttttc atttgaagaa acaaaagtga tagcacttaa ttgttcctac
    21361 tatttagaat attttctatg tcctttttat tccattttgt atcaataact atgaaatctt
    21421 taaagtatcc agaagagatt atttttagat caattttttt cttacctgat tctaaagatt
    21481 ttgttttctt aaacatatta tgatttcctt tcgactattt tcatataaat gttaacatag
    21541 tttatggatt catggaatgt taatctaatt taatagaaaa ggataattaa gtatatacgt
    21601 tttttcttat gtatgttata ctatgtatat acagaaagag gtgtctacta tggaaatgtt
    21661 acctataaaa aaatggggaa atagtaatgg ccttagattg ccaaagtata ttatggaata
    21721 tcttggaatt catacagaag acaaagtgaa gataatacaa gaagaagtaa acggtcagaa
    21781 gcggctaatt atcgaagcgg ctaatataga aaatgaatta acaattgaac agttatttga
    21841 aaattacact gatgaaagaa atcatgtgac gattcaaaat ttaggtgaag cagtaggtaa
    21901 tgaaaaatgg tgagaaaacc tagacaaggc gatattctat tattgaatac agcacctcga
    21961 tctggacacg aacagacagg taaaagacct tatattgttt taagtcatga tattattgcg
    22021 gattatagta acgttgttac agttgctcca atttctagta caactagaaa ctatccgcta
    22081 tatgtaaata taaactcaga atatgaaatg aagacaacag gaaaagtatt attagatcaa
    22141 ctaacgacaa ttgattatga agccagagag tgtatttttt tggaaaaagc gcatgatagt
    22201 ttagttgagg agttattgat gaaagttaga acagtttttc aaaaagtaag caaataaaat
    22261 agaaacagca gcatgatcaa ctattcgtga ttgaccatgc tgtctttttt tattctatac
    22321 acggtttgtc tcgtaacatt gtagtctttt gcaatcttag cgatcgcaac accttttttt
    22381 agatcctcaa cgatgttttt ataaacaaga cgacgttggg gatcttttgc attggcactg
    22441 tatagcttag gacgtccttt ataaacaccg ttcgcttttg caatcttaat gccttgtgcc
    22501 tggcgacgtt tcgattcggt acgttcttgt tcagcgatca tggccaaaat ttggatgatc
    22561 agatccttaa tgaatttatc caggagagga ttgccaattg cttcagccat gatcggtaaa
    22621 ctagtaatga tcagcttcac atttttcttc ttcaagtaat tgactgaagc gatgatctcg
    22681 tcataatttc ttccaagtcg atcaatagct tccacaataa aaatatcttg atctcggacg
    22741 taatctaatg cttcttggaa aacaggtcga tgagtaatcg ttgcgccaga ttgtttctcg
    22801 atgaaaattc tctctgcacc gaattttttc atttcttcaa tctggcgttg ttcattttga
    22861 tcgatggatg agacacgtat gtatgcaact ctcaaaactt ttacctactt tctgcaacta
    22921 tttaaaatac accctaatca tacacgagga agccatattt ttcaatgtta taccagtgtc
    22981 tatttagggt aaaccttata tagacaaaaa ctaatgatgg aggaaatagt atgagaattt
    23041 tttgtaagtg tctactgata acttattctc aaatgttgta aggattttat tcatttgtta
    23101 atattaaaga acggaactcc aaaaaagtcc gtactctaat ttgcagtctc tcactctttt
    23161 agagtgagag tttttattag attttcaaat taattagtaa agtgatagaa taaattgatc
    23221 atacaaatca aaagaagaag cagggtgata gcatacctat gcttcttttt ttatgtattt
    23281 agctatttct tctttacaat atcgaacata tgtttgtata atgtgaaaga atggagtgtt
    23341 atttatgatg gattattcaa aagagccagt aaatgattac tttttaatcg atatgaaaag
    23401 cttttacgca agtgtcgaat gtatagaaag aaatttagat ccattaacaa cagaacttgt
    23461 tgttatgagt cgagctgata atactggttc aggattgata ttagcttctt ctcctgaagc
    23521 aaaaaagcgg tatggtatta caaatgtgag tagaccacgt gacttaccac aaccatttcc
    23581 taaaacacta cacgttgttc caccacgtat gaacctatat atcaagcgaa atatgcaggt
    23641 aaataatatt ttcagaagat atgtggctga tgaagatcta ctgatttact cgatcgatga
    23701 atcaatctta aaagtgaccc gatcactgaa tctttttacg actgaaggaa cacgaagtca
    23761 acggagaaag aagctggctc aaatgatcca ggagaatatt aaagaagagc taggattgat
    23821 tgctacagta ggtgtcggag ataatcccct tttggctaaa ctagccttag acaacgaagc
    23881 aaagcataat gaaggatttg ttgcggaatg gacgtacgaa aacgttcctg aaaaagtatg
    23941 gaatattcct gaaatgacgg acttttgggg aattggctct cgaatgaaaa aaagactcaa
    24001 tcagatgggg attatgagca ttagagatct tgctaactgg aatccttata cgattaagaa
    24061 tagactaggt gtgattggct tacagctgta cttccatgct aatgggatcg atcgaacaga
    24121 tatagcaatc ccaccagaac cgacaaagga aaaatcatat ggaaattcac aagtgttacc
    24181 acgagattat actagaagaa atgaaatcga gctggtggta aaagaaatgg cggaacaagt
    24241 agcgatacgc attaggcagc ataactgtaa aacaggttgt gtccatttac acattggcac
    24301 gtcgatctta gaaacgagac cagggttttc acaccagatg aagatcccta tcacagataa
    24361 tacaaaggaa ttgcagaatt attgtctttt cttgtttgat aagtattatg aaggacaaga
    24421 agtaaggcat gttggaataa cctatagcaa gcttgtgtac accgattcgc ttcagctgga
    24481 tttatttagt gatccacaaa agcaaattga cgaagaaaat ttagataaaa ttattgacaa
    24541 gattcggcaa aaatatggtt ttacgtcgat tgtacatgct tcttcaatgt tagaaggcgc
    24601 tagaagcatt actagaagca cacttgttgg tggtcatgcg ggcggaaatg ggggaattaa
    24661 aaatgattga ttacaatgat cgtggacgtt taaagtgggc agggttttat ttatctgatc
    24721 atactgaaga aattgatgcc gacaatgaac aacgtgcaaa tcataatttg gcaaaagaac
    24781 aaatgacgac tgaagagatt gcggaagtat tgaacgctgc agtcataaaa aatagatcag
    24841 tatctattca aaaagaagaa cgaaacgctg aaggatacta tccagaagat atcattggca
    24901 agatcttagg tagtgatgag ctggggatct acgttggaaa agacaaaatt cactacgacg
    24961 aaatacgtca tatcgaattt taccaggata ataaatggag tcgattagaa tgaacattat
    25021 ccagcaatat gagctaaagt atataacctt tgatcagcta tcagaagaga tttggggtta
    25081 tggccaacgt ttgataaatg aggttggtgt tgagcgcttc tctttctatg tagaagctgc
    25141 agcaggttat cataatttta ggttttatat cttcccgtta tatatataag gtattttacg
    25201 gattctatag agttatctct atgaatcctt ttttgttttt acaaatagga gtagatacta
    25261 gaataatgcg tgtgttaaac tattattgca aacgcaataa taaaagaaag taggcttacg
    25321 caccatgtct atcaatacat ttgtttactc gcacccgatc aatgtttaca ttatcaagaa
    25381 tttaggaatc actgtagaac aattttgtga gttatatgcc tacccacaag gaacggttgc
    25441 aagctggata acccgacaac gtagaatcaa atcactacct gcttcattta tatatgatct
    25501 gagtcttgct tctagttgca acatgtctga tgtctatgaa aaattattga tactagagaa
    25561 tgagtacgat caatttaatt ccaatcaaaa aaagaaaaag aaaaaacaca tagattaata
    25621 ttgaaacgaa aaatagtatt tattttaaaa aaagagaaag tagaaaaaga tatttttcca
    25681 ttatttgatt aaagttactt ttaatcaaaa ctattgtaaa atagtacttg ttttatgtat
    25741 cttaaaatca aaaaactttg attaaagatt cttcaatcaa aaaaacttaa aaacattgat
    25801 ataatagcat ttaataaaaa taagtatctc gtaatcaaaa aaataatttg attacgagat
    25861 acttatttac atttacaaca gcaagttgta tacttaattt gaataaaaga tacttaatca
    25921 aaaggagcgt aataatatga atgcaaattc aatagtagtt ggtaatttta aaggaggaac
    25981 aggaaaatct acttctactc aaatgctagg ctttgtaaat gcattttaca aaaaaagaaa
    26041 aacattgctt atagatcttg atccacaagc aaatgcttca gaagttatga gtttcactgc
    26101 tgacaactta gggaatcatt tttatcaaga aaatgggttt cctaaaacta tatggaatgt
    26161 tctttacgac ggtagtttag acggcgctgt ccttccccta attgaaaatt tagatttaat
    26221 tgccggtaat attgctatga gtgactactc tgattttatg agcgctaaat ttccaaacga
    26281 taaattagct caatttgagt actttgcgaa cattctagca cctttaaaag aagaatatga
    26341 cgaaattttc attgatgtac caccttcact cggaactatt gtacagagtg caatgtactt
    26401 tgctgaatat gtagctatta tgcttcaaac acagccaaaa tcaattagag gggctgctga
    26461 ttatatagat tatatggaat ttttcactga aagatataat acacaactag gtattgctgg
    26521 aattattcca tttatgttag acacaaaaac aagtacagaa agctatatgt acaatgaagc
    26581 taaaaagtta tatggcgata accttatcaa cacaatcgtt ttcagaagtg ctagattgat
    26641 tagatacgat gaaactggta ttacattaga aacaaagaaa aatggggagc ttaaaaaagt
    26701 agacgcaaat ccacagaata ctttcatatc tattttagac gaactaaatg aacatattag
    26761 ttggtttgag gaggaataaa gatggctgaa agacaatcaa aactatttcc taacaagaaa
    26821 gcacgtccaa gaacgaatgg tatgaaagat atggaagaat ttacaaaatc tttatctata
    26881 tcttcagctg ataattccgc tcctaaagtt aatacaacag aaaaacattc tgatgataac
    26941 aagaatctaa aaaatccaaa taaaagtcat aaaggtaaag ctggcagaaa agctgaatac
    27001 aaagatccaa gactaaaaaa ggatttgaat acaaaaatct ctttaagtac caaattaaga
    27061 atccaacgcc ttatttcaag gaaatttgat aataaatctg aaggtgatgt aattgatatt
    27121 gctcttgatt atttggtatc ttcatttgat agagacgata gagattcatt gtataaagca
    27181 tacaaggaag acatggagtc aatgatacca attattcaag aaaaaaatga aaaagctaaa
    27241 aaacaaggta aactaacact agatatcacc gatgaaataa atcaacaaac tttaaaagaa
    27301 caaaaagaaa aatgggtatc agctaagttt gaatagaaga tacttaaaac aacataaact
    27361 attgattgaa gtatctggta atattgattt taagatacct caatcaatag ttttttcttt
    27421 aaaataagca tttatgtttg aataagagat actaaaatca aataaaagta tcttttaatc
    27481 aacaaactag tttgaataaa gttactcata atcaaattat aaatgatttt tagatactac
    27541 aatcagatag aaaccctatt aaattaactt tcttaattga ttaaaagata ctaaaatgag
    27601 attattttga ttttagtgcc aaaaaacaaa ctaaaatttt tgattttagt atccttaaat
    27661 caaattaaat gtatattacg agtcactata atcaaaggta atttattacg aatattgtct
    27721 tctcaataaa aagttcttga ttataagatc tttcaatcag atttattttt gaataaggtg
    27781 tcttccaatc aaaagtaata actgatttaa gtatctctta ttcaaaatat agttgtctga
    27841 aaataataaa ctgttaaact tattttgaag cctatattat tcctgatttg tatatcgaaa
    27901 ttcattagct atatacattt aaagaaatct aattatattt ttgataataa aaattgtacg
    27961 gatactagaa aagagggagt ttaatgtcta cagaatttca atctcaaaaa atg
//
