LOCUS       NZ_CP131804            28012 bp    DNA     circular CON 25-APR-2024
DEFINITION  Enterococcus faecium strain 2016N21-233 plasmid p2016N21-233-3,
            complete sequence.
ACCESSION   NZ_CP131804
VERSION     NZ_CP131804.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN36766204
            Assembly: GCF_038437885.1
KEYWORDS    RefSeq.
SOURCE      Enterococcus faecium
  ORGANISM  Enterococcus faecium
            Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
            Enterococcus.
REFERENCE   1  (bases 1 to 28012)
  AUTHORS   Chen,F.-J., Liao,Y.-C. and Chiu,Y.-T.
  TITLE     Rapid Diagnostics and Real-time Genomic Surveillance System for
            Pathogens from Culture
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 28012)
  AUTHORS   Chen,F.-J., Liao,Y.-C. and Chiu,Y.-T.
  TITLE     Direct Submission
  JOURNAL   Submitted (31-JUL-2023) National Institute of Infectious Diseases
            and Vaccinology, National Health Research Institutes, No. 35, Keyan
            Road, Zhunan Town, Miaoli County 350, Taiwan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 28-SEP-2022
            Assembly Method                   :: CCBGpipe v. 1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 80x
            Sequencing Technology :: Oxford Nanopore MinION and Illumina iSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_038437885.1-RS_2024_04_24
            Annotation Date                   :: 04/24/2024 14:04:14
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,196
            CDSs (total)                      :: 3,103
            Genes (coding)                    :: 2,933
            CDSs (with protein)               :: 2,933
            Genes (RNA)                       :: 93
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 71
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 170
            CDSs (without protein)            :: 170
            Pseudo Genes (ambiguous residues) :: 0 of 170
            Pseudo Genes (frameshifted)       :: 63 of 170
            Pseudo Genes (incomplete)         :: 101 of 170
            Pseudo Genes (internal stop)      :: 39 of 170
            Pseudo Genes (multiple problems)  :: 31 of 170
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP131804.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..28012
                     /organism="Enterococcus faecium"
                     /mol_type="genomic DNA"
                     /strain="2016N21-233"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1352"
                     /plasmid="p2016N21-233-3"
                     /geo_loc_name="Taiwan"
                     /collection_date="2016"
                     /collected_by="NHRI"
     gene            join(27983..28012,1..1056)
                     /locus_tag="Q7583_RS15710"
                     /old_locus_tag="Q7583_15635"
     CDS             join(27983..28012,1..1056)
                     /locus_tag="Q7583_RS15710"
                     /old_locus_tag="Q7583_15635"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002352763.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /protein_id="WP_002326891.1"
                     /translation="MSTEFQSQKMIIKNWGYKATNVYIEKYYKFPSFLIQNSKYSKMKD
                     SSKIAYMLFKNEFRRALHEKWIDDDGLLYLEFTQADLMDKLNCYQGKVKTILNELETYN
                     LISVVKGEFNPKTKKNEKNKYYLLQPEISADDLFIQNSFDDDLSETIDKSTSSRNAEIA
                     RREETAKTLDNTGNAEIARREKTAETLDNTGNAEIAQDYYINKSLDTKRHLKDTETDQL
                     QNQVLLDNFVEIMKEDSINTFVPEKVLSLIKTFSNTYEEAQQTVTTIHNAKHKAEELEK
                     TVVVYEELESYGIDADKGLYMTLLKAYQKQKTEKVNNLQNLIFVYVKNWFVEKAIAAKL
                     ANEQRETFNELPTVSTENWLE"
                     /name="replication initiator protein A"
     gene            complement(1672..2352)
                     /locus_tag="Q7583_RS15715"
                     /old_locus_tag="Q7583_15640"
     CDS             complement(1672..2352)
                     /locus_tag="Q7583_RS15715"
                     /old_locus_tag="Q7583_15640"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="WP_002343844.1"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIGADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKLYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            complement(<2857..5007)
                     /locus_tag="Q7583_RS15720"
                     /old_locus_tag="Q7583_15645"
                     /pseudo=""
     CDS             complement(<2857..5007)
                     /locus_tag="Q7583_RS15720"
                     /old_locus_tag="Q7583_15645"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000684984.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="Tn3 family transposase"
                     /name="Tn3 family transposase"
     gene            5153..5728
                     /locus_tag="Q7583_RS15725"
                     /old_locus_tag="Q7583_15650"
     CDS             5153..5728
                     /locus_tag="Q7583_RS15725"
                     /old_locus_tag="Q7583_15650"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001226076.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_001226076.1"
                     /translation="MRKIGYIRVSSTNQNPSRQFQQLNEIGMDIIYEEKVSGATKDREQ
                     LQKVLDDLQEDDIIYVTDLTRITRSTQDLFELIDNIRDKKASLKSLKDTWLDLSEDNPY
                     SQFLITVMAGVNQLERDLIRMRQREGIELAKKEGKFKGRLKKYHKNHAGMNYAVKLYKE
                     GNMTVNQICEITNVSRASLYRKLSEVNN"
                     /name="recombinase family protein"
     gene            6016..7335
                     /locus_tag="Q7583_RS15730"
                     /old_locus_tag="Q7583_15655"
     CDS             6016..7335
                     /locus_tag="Q7583_RS15730"
                     /old_locus_tag="Q7583_15655"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002338419.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS1380-like element IS1678 family transposase"
                     /protein_id="WP_000202380.1"
                     /translation="MTSLHKNQVKFNSNITISHTGGQLSSDSGLVLVKELMNIFGFSEL
                     AKQHIHIEDERAYFTHDNLSILEQFIMQLIAGYSADSAANLLRQDPVFKAVLDRKELAS
                     QSSLSRFLDRLSEENIHELQALNQELIDKARLIRNDTELIIDLDSTHSDTFGHQEQTNY
                     NTHYQTYGYHPLVAFDGLTGDFLKAELRSGNQYTSKGVKEFLTPLLEHYNHSLPNTDIL
                     VRGDSGFATPGVYDSCESKKSHYVIRLKNNRRLGQIAEKSVLYGDNQKWEEREVQYFST
                     TYQAQSWSQSRRVCIRSTREAGELLFRHEFIVTNLSENVSPDTIFSIYAKRGTMENFIK
                     EAKAGFYFDKTDSPRFLENHVRMMLSLIAYNLVNFLRTIGFEEVQKGMTIHSIRLKFLK
                     VAGKLVQTGRRVYLKLSSYHVYQNEFYRVFARLRRASQWI"
                     /name="IS1380-like element IS1678 family transposase"
     gene            7625..8320
                     /gene="vanR-A"
                     /locus_tag="Q7583_RS15735"
                     /old_locus_tag="Q7583_15660"
     ARG             7626..8317
                     /name="vanR-A"
                     /gene="vanR-A"
                     /gene_name="vancomycin resistance response regulator
                     transcription factor VanR-A"
                     /tool="amrfinderplus"
                     /drug_class="GLYCOPEPTIDE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            8298..9452
                     /locus_tag="Q7583_RS15740"
                     /old_locus_tag="Q7583_15665"
     CDS             8298..9452
                     /locus_tag="Q7583_RS15740"
                     /old_locus_tag="Q7583_15665"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002305818.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="vancomycin resistance histidine kinase VanS-A"
                     /protein_id="WP_002305818.1"
                     /translation="MVIKLKNKKNDYSKLERKLYMYIVAIVVVAIVFVLYIRSMIRGKL
                     GDWILSILENKYDLNHLDAMKLYQYSIRNNIDIFIYVAIVISILILCRVMLSKFAKYFD
                     EINTGIDVLIQNEDKQIELSAEMDVMEQKLNTLKRTLEKREQDAKLAEQRKNDVVMYLA
                     HDIKTPLTSIIGYLSLLDEAPDMPVDQKAKYVHITLDKAYRLEQLIDEFFEITRYNLQT
                     ITLTKTHIDLYYMLVQMTDEFYPQLSAHGKQAVIHAPEDLTVSGDPDKLARVFNNILKN
                     AAAYSEDNSIIDITAGLSGDVVSIEFKNTGSIPKDKLAAIFEKFYRLDNARSSDTGGAG
                     LGLAIAKEIIVQHGGQIYAESNDNYTTFRVELPAMPDLVDKRRS"
                     /name="vancomycin resistance histidine kinase VanS-A"
     gene            complement(9550..10842)
                     /locus_tag="Q7583_RS15745"
                     /old_locus_tag="Q7583_15670"
     CDS             complement(9550..10842)
                     /locus_tag="Q7583_RS15745"
                     /old_locus_tag="Q7583_15670"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016628567.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ISL3-like element IS1251 family transposase"
                     /protein_id="WP_000122610.1"
                     /translation="MSYTHLIKETLDILDLSVTFNENCLTKEKYKGQICHIYRGNLIYT
                     AQECIHCKHQIASDIVRWGTTTVRLLMNDVSEYRTYLELKKQRFKCKACQRTFVADTSV
                     AKKHCFISEKVRWSVVTRLKKNTSMTEIAAQKNLSVSSVYRIMKRFYRPLNPFRTPLPK
                     VLCFDEFKSVRGVSGAMSFIMMDGQTQRLLDIVENRQLPFLKRYFSHFSREIREAVEWI
                     VIDMYAPYVSLVKKLFPKAQLIIDRFHIVQHIGRTFRNHRIKETNQLLKSKEQKHYQLG
                     KQLKRYWKLLQKDERKLDYTRRLWRPGFKAHLTETDIVDRLLKGSPALRVGYQLYQDFL
                     YAVKERDYVSFEELLTNNIMLPEGYQTTLRTFQKFLPQIKNALQQSYSNGPLECLNNHI
                     KVLKRNAYGFRSFYNFKLRIMIRHGNALIFN"
                     /name="ISL3-like element IS1251 family transposase"
     gene            11174..12142
                     /locus_tag="Q7583_RS15750"
                     /old_locus_tag="Q7583_15675"
     CDS             11174..12142
                     /locus_tag="Q7583_RS15750"
                     /old_locus_tag="Q7583_15675"
                     /EC_number="1.1.1.28"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001059542.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-lactate dehydrogenase VanH-A"
                     /protein_id="WP_001059542.1"
                     /translation="MNNIGITVYGCEQDEADAFHALSPRFGVMATIINANVSESNAKSA
                     PFNQCISVGHKSEISASILLALKRAGVKYISTRSIGCNHIDTTAAKRMGITVDNVAYSP
                     DSVADYTMMLILMAVRNVKSIVRSVEKHDFRLDSDRGKVLSDMTVGVVGTGQIGKAVIE
                     RLRGFGCKVLAYSRSRSIEVNYVPFDELLQNSDIVTLHVPLNTDTHYIISHEQIQRMKQ
                     GAFLINTGRGPLVDTYELVKALENGKLGGAALDVLEGEEEFFYSDCTQKPIDNQFLLKL
                     QRMPNVIITPHTAYYTEQALRDTVEKTIKNCLDFERRQEHE"
                     /name="D-lactate dehydrogenase VanH-A"
     gene            12135..13166
                     /gene="vanA"
                     /locus_tag="Q7583_RS15755"
                     /old_locus_tag="Q7583_15680"
     ARG             12136..13163
                     /name="vanA"
                     /gene="vanA"
                     /gene_name="D-alanine--(R)-lactate ligase VanA"
                     /tool="amrfinderplus"
                     /drug_class="GLYCOPEPTIDE"
                     /identity="99.71"
                     /coverage="100.0"
     gene            13172..13780
                     /locus_tag="Q7583_RS15760"
                     /old_locus_tag="Q7583_15685"
     CDS             13172..13780
                     /locus_tag="Q7583_RS15760"
                     /old_locus_tag="Q7583_15685"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000402347.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="D-Ala-D-Ala dipeptidase VanX-A"
                     /protein_id="WP_000402348.1"
                     /translation="MEIGFTFLDEIVHGVRWDAKYATWDNFTGKPVDGYEVNRIVGTYE
                     LAESLLKAKELAATQGYGLLLWDGYRPNRAVNCFMQWAAQPENNLTKESYYPNIDRTEM
                     ISKGYVASKSSHSRGSAIDLTLYRLDTGELVPMGSRFDFMDERSHHAANGISCNEAQNR
                     RRLRSIMENSGFEAYSLEWWHYVLRDEPYPNSYFDFPVK"
                     /name="D-Ala-D-Ala dipeptidase VanX-A"
     gene            14208..15119
                     /gene="vanY"
                     /locus_tag="Q7583_RS15765"
                     /old_locus_tag="Q7583_15690"
     CDS             14208..15119
                     /gene="vanY"
                     /locus_tag="Q7583_RS15765"
                     /old_locus_tag="Q7583_15690"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001812592.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VanY-A/VanY-F/VanY-M family D-Ala-D-Ala
                     carboxypeptidase"
                     /protein_id="WP_000732308.1"
                     /translation="MKKLFFLLLLLFLIYLGYDYVNEALFSQEKVEFQNYDQNPKEHLE
                     NSGTSENTQEKTITEEQVYQGNLLLINSKYPVRQESVKSDIVNLSKHDELINGYGLLDS
                     NIYMSKEIAQKFSEMVNDAVKGGVSHFIINSGYRDFDEQSVLYQEMGAEYALPAGYSEH
                     NSGLSLDVGSSLTKMERAPEGKWIEENAWKYGFILRYPEDKTELTGIQYELWHIRYVGL
                     PHSAIMKEKNFVLEEYMDYLKEEKTISVSVNGEKYEIFYYPVTKNTTIHVPTNLRYEIS
                     GNNIDGVIVTVFPGSTHTNSRR"
                     /name="vanY"
     gene            15272..15757
                     /gene="vanZ-A"
                     /locus_tag="Q7583_RS15770"
                     /old_locus_tag="Q7583_15695"
     ARG             15273..15754
                     /name="vanZ-A"
                     /gene="vanZ-A"
                     /gene_name="glycopeptide resistance protein VanZ-A"
                     /tool="amrfinderplus"
                     /drug_class="GLYCOPEPTIDE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(16044..16373)
                     /locus_tag="Q7583_RS15775"
                     /old_locus_tag="Q7583_15700"
     CDS             complement(16044..16373)
                     /locus_tag="Q7583_RS15775"
                     /old_locus_tag="Q7583_15700"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000754864.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_000754864.1"
                     /translation="MKKVCQVTVVHKEKVNGIKNKLDQKDFSNLLVLGKCFSDFSRIKI
                     FYALETYKEMCVCDLAEILTASVATTSHHLRFLKKHGMAKSRQDGKVVYYSLANEDILS
                     AIRVF"
                     /name="metalloregulator ArsR/SmtB family transcription
                     factor"
     gene            16678..17007
                     /locus_tag="Q7583_RS15780"
                     /old_locus_tag="Q7583_15705"
     CDS             16678..17007
                     /locus_tag="Q7583_RS15780"
                     /old_locus_tag="Q7583_15705"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005877489.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000629052.1"
                     /translation="MITKTRKQGNSIMLTVPKEFDVPNGVEVEAKLVENGILYEFVEPK
                     KEFFDFSEDILADILSEGYSKQEILKEFRNRKNALTSAFKSIAEDTVANSKPMTKEELA
                     AEIGL"
                     /name="hypothetical protein"
     gene            16997..17262
                     /locus_tag="Q7583_RS15785"
                     /old_locus_tag="Q7583_15710"
                     /pseudo=""
     CDS             16997..17262
                     /locus_tag="Q7583_RS15785"
                     /old_locus_tag="Q7583_15710"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002292679.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            17246..17584
                     /locus_tag="Q7583_RS15790"
                     /old_locus_tag="Q7583_15715"
     CDS             17246..17584
                     /locus_tag="Q7583_RS15790"
                     /old_locus_tag="Q7583_15715"
                     /inference="COORDINATES: protein motif:HMM:NF020419.4"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="nucleotidyl transferase AbiEii/AbiGii toxin
                     family protein"
                     /protein_id="WP_342080287.1"
                     /translation="MKDFYDLYMIPKLERIDEKNLYKSVQGTFKERNNQSVFKHLYDQE
                     MPQLVKDEGLREKWKRYQQENYFAKDISFESTLTSVDSLMQSIVEQEKAERKQNFKRSQ
                     QMNQEMER"
                     /name="nucleotidyl transferase AbiEii/AbiGii toxin family
                     protein"
     gene            17587..18072
                     /gene="ssb"
                     /locus_tag="Q7583_RS15795"
                     /old_locus_tag="Q7583_15720"
     CDS             17587..18072
                     /gene="ssb"
                     /locus_tag="Q7583_RS15795"
                     /old_locus_tag="Q7583_15720"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002339775.1"
                     /GO_function="GO:0003697 - single-stranded DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA];
                     GO:0006281 - DNA repair [Evidence IEA]; GO:0006260 - DNA
                     replication [Evidence IEA]; GO:0006351 - DNA-templated
                     transcription [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="single-stranded DNA-binding protein"
                     /protein_id="WP_002296241.1"
                     /translation="MINNVTLVGRLTKDPDLRYTASGTAVATFSLAVNRNFTNQNGNRE
                     ADFINCVIWRKPAETMATLAKKGSLIGVVGRIQTRTYDNQQGQRVYVTEVVADNFQLLE
                     SKAATESRMHADQSSSSPSPTTFEQRDTATPNNNGLNASQNPFGGQSIDISDDDLPF"
                     /name="ssb"
     gene            18438..18698
                     /locus_tag="Q7583_RS15800"
                     /old_locus_tag="Q7583_15725"
     CDS             18438..18698
                     /locus_tag="Q7583_RS15800"
                     /old_locus_tag="Q7583_15725"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002339774.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002296240.1"
                     /translation="MNKYVGLLDKIRVIKTQPLLVRFTLQTIHESINCVVADIEIIDKL
                     LIMDDGKYNIAVTGHFNKRNQLVIASMYVRNPDHFTRSMGI"
                     /name="hypothetical protein"
     gene            19139..19345
                     /locus_tag="Q7583_RS15805"
                     /old_locus_tag="Q7583_15730"
     CDS             19139..19345
                     /locus_tag="Q7583_RS15805"
                     /old_locus_tag="Q7583_15730"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016853414.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002296239.1"
                     /translation="MRKKFDYWGVPFSELFPNYHAPHTVECDCGERAKCIKSYRLYQCP
                     TCGKKYTLSYGDYILIDEKGKKR"
                     /name="hypothetical protein"
     gene            19345..19596
                     /locus_tag="Q7583_RS15810"
                     /old_locus_tag="Q7583_15735"
     CDS             19345..19596
                     /locus_tag="Q7583_RS15810"
                     /old_locus_tag="Q7583_15735"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002314430.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002296238.1"
                     /translation="MKTQHKLLTVKEVVQILVDKEVISEKVAEALLIPRYWTIETPLVE
                     DAPTMLFEDLVKIAGYELHYQENMETYEIEYWLTKLEN"
                     /name="hypothetical protein"
     gene            19611..20048
                     /locus_tag="Q7583_RS15815"
                     /old_locus_tag="Q7583_15740"
     CDS             19611..20048
                     /locus_tag="Q7583_RS15815"
                     /old_locus_tag="Q7583_15740"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016922517.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002296237.1"
                     /translation="MAQNYYDEFVKLPLDKMAQKMEDMTFLYHETRVPKKHYKEKLSVA
                     VEEMIESGVEMNLIATYYRTLEELKKQNGKWFFQALLCLEVGVKPSTIKPSEYQALELT
                     YAKFAQIKKAKAMASDWLDTFESIEKNGAFYTIESEEKDNE"
                     /name="hypothetical protein"
     gene            20041..20748
                     /locus_tag="Q7583_RS15820"
                     /old_locus_tag="Q7583_15745"
     CDS             20041..20748
                     /locus_tag="Q7583_RS15820"
                     /old_locus_tag="Q7583_15745"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002318326.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_098379831.1"
                     /translation="MNKVVYQLTTEDVSQFLTDKEHLNEVIRRIQKDFSCMEEMKYFIQ
                     RVEEQLYMESETSQTKVTVSHNHLDVYKRRPETVKKGTELLRLETEKYIMNVYLERSEL
                     VENFVSYTICRKHYYSESEYYSIFESMELMEEEMEELNSKNATVDDYYLVFTRFLTCGT
                     ESIVLMGMDYELAVPEAFLREYVEEVDNPGDDWYTTLTDFLDTYTYDDTEEIQNELDRK
                     RMPYQRFERKKGK"
                     /name="hypothetical protein"
     gene            20913..21113
                     /locus_tag="Q7583_RS15825"
                     /old_locus_tag="Q7583_15750"
     CDS             20913..21113
                     /locus_tag="Q7583_RS15825"
                     /old_locus_tag="Q7583_15750"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002341525.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002330566.1"
                     /translation="MNKIIPLLFVLFVGEILMRHAAAVHLNFVVFLGILVFCLIFWRFV
                     LALVSLLFKMIAAIFFIGLFR"
                     /name="hypothetical protein"
     gene            21129..21308
                     /locus_tag="Q7583_RS15830"
                     /old_locus_tag="Q7583_15755"
     CDS             21129..21308
                     /locus_tag="Q7583_RS15830"
                     /old_locus_tag="Q7583_15755"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002295613.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002305761.1"
                     /translation="MPIAIGNKRLPVTLDEKRQKELQQLKQKYGKSESKIMCIALDLLI
                     AQEKAGFDIPALKK"
                     /name="hypothetical protein"
     gene            21649..21912
                     /locus_tag="Q7583_RS15835"
                     /old_locus_tag="Q7583_15760"
     CDS             21649..21912
                     /locus_tag="Q7583_RS15835"
                     /old_locus_tag="Q7583_15760"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002329851.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002287514.1"
                     /translation="MEMLPIKKWGNSNGLRLPKYIMEYLGIHTEDKVKIIQEEVNGQKR
                     LIIEAANIENELTIEQLFENYTDERNHVTIQNLGEAVGNEKW"
                     /name="hypothetical protein"
     gene            21906..22256
                     /locus_tag="Q7583_RS15840"
                     /old_locus_tag="Q7583_15765"
     CDS             21906..22256
                     /locus_tag="Q7583_RS15840"
                     /old_locus_tag="Q7583_15765"
                     /EC_number="3.1.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016610020.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003723 - RNA binding [Evidence IEA]; GO:0004521 - RNA
                     endonuclease activity [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system PemK/MazF family
                     toxin"
                     /protein_id="WP_002321032.1"
                     /translation="MVRKPRQGDILLLNTAPRSGHEQTGKRPYIVLSHDIIADYSNVVT
                     VAPISSTTRNYPLYVNINSEYEMKTTGKVLLDQLTTIDYEARECIFLEKAHDSLVEELL
                     MKVRTVFQKVSK"
                     /name="type II toxin-antitoxin system PemK/MazF family
                     toxin"
     gene            complement(22280..22894)
                     /locus_tag="Q7583_RS15845"
                     /old_locus_tag="Q7583_15770"
     CDS             complement(22280..22894)
                     /locus_tag="Q7583_RS15845"
                     /old_locus_tag="Q7583_15770"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001261742.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_342080289.1"
                     /translation="MRVAYIRVSSIDQNEQRQIEEMKKFGAERIFIEKQSGATITHRPV
                     FQEALDYVRDQDIFIVEAIDRLGRNYDEIIASVNYLKKKNVKLIITSLPIMAEAIGNPL
                     LDKFIKDLIIQILAMIAEQERTESKRRQAQGIKIAKANGVYKGRPKLYSANAKDPQRRL
                     VYKNIVEDLKKGVAIAKIAKDYNVTRQTVYRIKKDSMVNHE"
                     /name="recombinase family protein"
     gene            23344..24669
                     /locus_tag="Q7583_RS15850"
                     /old_locus_tag="Q7583_15775"
     CDS             23344..24669
                     /locus_tag="Q7583_RS15850"
                     /old_locus_tag="Q7583_15775"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002335330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Y-family DNA polymerase"
                     /protein_id="WP_000969590.1"
                     /translation="MMDYSKEPVNDYFLIDMKSFYASVECIERNLDPLTTELVVMSRAD
                     NTGSGLILASSPEAKKRYGITNVSRPRDLPQPFPKTLHVVPPRMNLYIKRNMQVNNIFR
                     RYVADEDLLIYSIDESILKVTRSLNLFTTEGTRSQRRKKLAQMIQENIKEELGLIATVG
                     VGDNPLLAKLALDNEAKHNEGFVAEWTYENVPEKVWNIPEMTDFWGIGSRMKKRLNQMG
                     IMSIRDLANWNPYTIKNRLGVIGLQLYFHANGIDRTDIAIPPEPTKEKSYGNSQVLPRD
                     YTRRNEIELVVKEMAEQVAIRIRQHNCKTGCVHLHIGTSILETRPGFSHQMKIPITDNT
                     KELQNYCLFLFDKYYEGQEVRHVGITYSKLVYTDSLQLDLFSDPQKQIDEENLDKIIDK
                     IRQKYGFTSIVHASSMLEGARSITRSTLVGGHAGGNGGIKND"
                     /name="Y-family DNA polymerase"
     gene            24662..25012
                     /locus_tag="Q7583_RS15855"
                     /old_locus_tag="Q7583_15780"
     CDS             24662..25012
                     /locus_tag="Q7583_RS15855"
                     /old_locus_tag="Q7583_15780"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002359653.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_342080290.1"
                     /translation="MIDYNDRGRLKWAGFYLSDHTEEIDADNEQRANHNLAKEQMTTEE
                     IAEVLNAAVIKNRSVSIQKEERNAEGYYPEDIIGKILGSDELGIYVGKDKIHYDEIRHI
                     EFYQDNKWSRLE"
                     /name="hypothetical protein"
     gene            25009..25188
                     /locus_tag="Q7583_RS15860"
                     /old_locus_tag="Q7583_15785"
     CDS             25009..25188
                     /locus_tag="Q7583_RS15860"
                     /old_locus_tag="Q7583_15785"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001021554.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001021554.1"
                     /translation="MNIIQQYELKYITFDQLSEEIWGYGQRLINEVGVERFSFYVEAAA
                     GYHNFRFYIFPLYI"
                     /name="hypothetical protein"
     gene            25324..25617
                     /locus_tag="Q7583_RS15865"
                     /old_locus_tag="Q7583_15790"
     CDS             25324..25617
                     /locus_tag="Q7583_RS15865"
                     /old_locus_tag="Q7583_15790"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002352765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002326890.1"
                     /translation="MSINTFVYSHPINVYIIKNLGITVEQFCELYAYPQGTVASWITRQ
                     RRIKSLPASFIYDLSLASSCNMSDVYEKLLILENEYDQFNSNQKKKKKKHID"
                     /name="hypothetical protein"
     gene            25936..26778
                     /locus_tag="Q7583_RS15870"
                     /old_locus_tag="Q7583_15795"
     CDS             25936..26778
                     /locus_tag="Q7583_RS15870"
                     /old_locus_tag="Q7583_15795"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002323027.1"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ParA family protein"
                     /protein_id="WP_002323027.1"
                     /translation="MNANSIVVGNFKGGTGKSTSTQMLGFVNAFYKKRKTLLIDLDPQA
                     NASEVMSFTADNLGNHFYQENGFPKTIWNVLYDGSLDGAVLPLIENLDLIAGNIAMSDY
                     SDFMSAKFPNDKLAQFEYFANILAPLKEEYDEIFIDVPPSLGTIVQSAMYFAEYVAIML
                     QTQPKSIRGAADYIDYMEFFTERYNTQLGIAGIIPFMLDTKTSTESYMYNEAKKLYGDN
                     LINTIVFRSARLIRYDETGITLETKKNGELKKVDANPQNTFISILDELNEHISWFEEE"
                     /name="ParA family protein"
     gene            26781..27335
                     /locus_tag="Q7583_RS15875"
                     /old_locus_tag="Q7583_15800"
     CDS             26781..27335
                     /locus_tag="Q7583_RS15875"
                     /old_locus_tag="Q7583_15800"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002323026.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002323026.1"
                     /translation="MAERQSKLFPNKKARPRTNGMKDMEEFTKSLSISSADNSAPKVNT
                     TEKHSDDNKNLKNPNKSHKGKAGRKAEYKDPRLKKDLNTKISLSTKLRIQRLISRKFDN
                     KSEGDVIDIALDYLVSSFDRDDRDSLYKAYKEDMESMIPIIQEKNEKAKKQGKLTLDIT
                     DEINQQTLKEQKEKWVSAKFE"
                     /name="hypothetical protein"
     ARG             11175..12139
                     /name="vanH-A"
                     /gene="vanH-A"
                     /gene_name="D-lactate dehydrogenase VanH-A"
                     /tool="amrfinderplus"
                     /drug_class="GLYCOPEPTIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             13173..13777
                     /name="vanX-A"
                     /gene="vanX-A"
                     /gene_name="D-Ala-D-Ala dipeptidase VanX-A"
                     /tool="amrfinderplus"
                     /drug_class="GLYCOPEPTIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             8299..9449
                     /name="vanS-A"
                     /gene="vanS-A"
                     /gene_name="vancomycin resistance histidine kinase VanS-A"
                     /tool="amrfinderplus"
                     /drug_class="GLYCOPEPTIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             14209..15116
                     /name="vanY-A"
                     /gene="vanY-A"
                     /gene_name="D-Ala-D-Ala carboxypeptidase VanY-A"
                     /tool="amrfinderplus"
                     /drug_class="GLYCOPEPTIDE"
                     /identity="99.67"
                     /coverage="100.0"
     ARG             11175..12142
                     /name="vanH gene in vanA cluster"
                     /gene="vanH gene in vanA cluster"
                     /gene_name="vanH; glycopeptide resistance gene cluster"
                     /tool="rgi"
                     /drug_class="glycopeptide antibiotic"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             7626..8320
                     /name="vanR gene in vanA cluster"
                     /gene="vanR gene in vanA cluster"
                     /gene_name="glycopeptide resistance gene cluster; vanR"
                     /tool="rgi"
                     /drug_class="glycopeptide antibiotic"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             14209..15119
                     /name="vanY gene in vanA cluster"
                     /gene="vanY gene in vanA cluster"
                     /gene_name="vanY; glycopeptide resistance gene cluster"
                     /tool="rgi"
                     /drug_class="glycopeptide antibiotic"
                     /identity="99.67"
                     /coverage="100.0"
     ARG             15273..15757
                     /name="vanZ gene in vanA cluster"
                     /gene="vanZ gene in vanA cluster"
                     /gene_name="vanZ; glycopeptide resistance gene cluster"
                     /tool="rgi"
                     /drug_class="glycopeptide antibiotic"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             8311..9452
                     /name="vanS gene in vanA cluster"
                     /gene="vanS gene in vanA cluster"
                     /gene_name="vanS; glycopeptide resistance gene cluster"
                     /tool="rgi"
                     /drug_class="glycopeptide antibiotic"
                     /identity="99.74"
                     /coverage="98.96"
     ARG             13173..13780
                     /name="vanX gene in vanA cluster"
                     /gene="vanX gene in vanA cluster"
                     /gene_name="vanX; glycopeptide resistance gene cluster"
                     /tool="rgi"
                     /drug_class="glycopeptide antibiotic"
                     /identity="99.5"
                     /coverage="100.0"
     Typing          650..1056
                     /name="rep_cluster_889"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="95.588"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 attattaaaa attggggata taaagcaaca aatgtttata ttgaaaaata ttataaattt
       61 cctagttttt taattcagaa ttctaaatat tcaaaaatga aagacagctc aaaaatagct
      121 tatatgcttt ttaaaaatga atttcgtaga gctttgcatg aaaaatggat cgacgatgat
      181 ggactattat atttggaatt tacacaagcc gatctaatgg ataaattaaa ttgctatcaa
      241 ggcaaagtaa aaaccatttt aaacgagtta gaaacatata atttgatttc tgtcgtaaaa
      301 ggagaattta acccaaaaac gaaaaaaaat gaaaaaaata aatactattt acttcaacct
      361 gaaataagtg ccgatgatct ttttattcaa aattctttcg atgacgattt aagcgaaact
      421 attgataaat caacctcttc tcggaatgcg gaaatcgcac gtcgagagga aactgctaaa
      481 acccttgata atactggaaa tgcggaaatc gcacgtcgag aaaaaacagc tgaaaccctt
      541 gataacactg gaaatgcgga aatcgcacaa gattattata ttaataaatc tttagacact
      601 aaaagacact taaaagacac tgaaacagac caattacaaa atcaagtttt gctagataac
      661 ttcgttgaaa tcatgaaaga agacagcata aacacatttg taccagaaaa ggtattaagc
      721 ttgataaaaa cattttctaa cacttacgaa gaagcccaac aaactgtcac cacaatacac
      781 aacgcaaaac ataaagccga ggaacttgag aagacggtag ttgtgtatga agaactggaa
      841 tcttatggaa ttgatgctga caaaggatta tatatgactt tactgaaagc ttatcaaaaa
      901 caaaaaactg aaaaagtaaa caatttgcag aatctaattt tcgtttatgt aaaaaattgg
      961 tttgtcgaaa aagctattgc ggcaaagctt gcaaacgaac aaagagaaac atttaacgaa
     1021 ttaccaacag ttagtacgga aaattggtta gagtagttga taaaaagcga tcactataaa
     1081 aatgatcaat tttaaattag aactttttta tgattttaat tttattacaa atgttacaaa
     1141 taaatagtta ttattccgga gtttttagat taaaagttta tgaaaacaat cacaaacgta
     1201 ggttttaaag tcataatcgt tagatatttt agttattttt cattcaaaaa aatagggaac
     1261 tagtgtttgc atatgtgctt ttttgagtta taataattca tgaagagagg taattcactt
     1321 atttccccaa gctgaaaagc ctgatattac ttcttttcag gcagtgctgc taatattcaa
     1381 ttacactttt ttgtatattt ttagttgttt taaatttaat tgtctgatat gcttgtgatg
     1441 aattgatttt cgttctgcac ttttggacga taaattgtga taattgaaaa tacaaaaaaa
     1501 agaaaggccc ctgtaaggct cgggagactg gtaatctccg tcagtgtcct acaggaaagc
     1561 attaagatga cgccttaatg cgtgcccttc agtgttacgg tattacccgc aacggacggt
     1621 tctgttgcaa agttttaaat aaagaataaa atcccttacg gtatctatga tttaagctgg
     1681 gattcccaat aataccttga tttcagtaca gaccgaaaac ccgaagagag tgccttcttt
     1741 tcgggttttc ttatataatc ctcgaatggc ttccatgcct ttaatcgtgg tagaggcagt
     1801 gcgtaaactt cgatataatt tattgcgtct ctttactgga cgatggtctt gttcaatcaa
     1861 attattcagg tatttaatgg tacgatgttc tgtcccttga taaaagccgt attcttttag
     1921 tttcttaaag gcacttgtaa tagagggggc tttatctgtg actacaacct tcggttcatc
     1981 aaactgcttc actaaccgct taagaaaagc ataggctgct tgtgtgtccc gttttttacg
     2041 taaccaaata tccaaggtta aaccatctgc accgatggct cgatacaaat aatgccattt
     2101 tcctttaatt ttgatgtacg tttcatccat tttccatgaa taaaaggatt ttttattttt
     2161 ctttttccaa atttgataga gtagtttgcc atattcttgc acccaacgat aaatcgtcgt
     2221 atgagaaacg ttaatgccac gatcatataa gatttcttga acttcacgat agctaaggtt
     2281 ataacgaaga tagtagccca cggctacaat aatcacatcc tgctgaaatt gctttccttt
     2341 aaaatgattc atcgtcattc ctcctgctat ctttttctat tattctacct tatttgatag
     2401 tagatttaaa actttgcaac agaacccgta taatgaactt gagttacgga actaggtgaa
     2461 gtagtttccg taaaggtcga gagtgcgtca acactgctcg actatttttt tactcttttt
     2521 tctcattttc tttgattata gcactcctct agaaaaaata aaaagacctc agggaatttc
     2581 attccccgaa ccccttgagc ctcctcctgc cgaaatagaa tggcgctgcc agcatttatt
     2641 tcgttcagct atcggctaca caatctaaca cgaccgttcc gctaccagtc gccttacagg
     2701 ctccattttc gctcctctaa cgtgtttcac cgattgtgcc gataactaaa cgaaataaac
     2761 gctaaaaccg ctcagaacgc aaaatatgcc attttagagc tattgtagaa aatatagttt
     2821 gaaatgcaat tttcttcttt cagcttttta tttcccactt gtaaatcggt agatggtggc
     2881 tccttttcca gttccataat gtggatttgc atctgcatgt agtgatgaaa cacctagctg
     2941 cattctcata ccatctgacg aagatgttgt accgtcgccc caatagaaag gcaattgtaa
     3001 tttatgatga aagtttacta atatggcttg ggctttattc atggcatctt catacatgcg
     3061 ccattgagat acattggcta gttgcttata tgtaagtccg ggtgtggctt cggccatctt
     3121 gctcaagcca atattcattc ccattcctaa aagggcagcc atgataatga ttgtttcttc
     3181 cttatctggt tttcgattat tggaagcatg agtgaattgc tcatgaaatc ctgttatatg
     3241 ggccacatcc atgagtaaat cagttaattt tattcttggt agcatctgat aaaggcttgc
     3301 actaaatttt tttgcttctt ctggaacatc tttttctaag cgtgcaagtg atagctttcc
     3361 tttttcaaga gaaaccccat ctaacttatt ggaattggca gctaaccact ttaacctttc
     3421 attaaagctg ctggttctct ccgttatata atcttcgaat gataaactaa ctgataatct
     3481 cgtattcccc ttcgattgat tccatgtatc ttccgaaaac aaatattcct caaaatccct
     3541 atattgtctg ctgccaacaa tggaaacatc tcctgcccga acatgctccc gaagttctgt
     3601 taaaacagcc atttcatagt aatgacgatt aattgttgta ccatcatcct cgtataaatg
     3661 tcttttccat cgttttgaaa taaaatccac aggtgagtca tcaggcactt ttcgctttcc
     3721 agattcgttc attcctcgga taatctcaac agcttgtaaa agtggctcat ttgcctttgt
     3781 agaatgaaat tccaatactc ttaatagcgt tggcgtatat tttcttagtg aataaaaccg
     3841 tttttgcagt aagtctaaat aatcatagtc ggcaggacgt gcaagttcct gagcctcttc
     3901 tactgaagag acaaaggtat tccattcaat aaccgattct aaaaccttaa aaacgtctaa
     3961 tttttcctct cttgctttaa ttaatgcttg tccgatgttc gtaaagtgta taactttctc
     4021 atttagcttt ttaccgtttt gtttctggat ttcctcttga gccttacgac cttttgataa
     4081 caaactaagt atttgcctat catgaatttc aaacgcttta tccgttagct cctgagtaag
     4141 ttgtaataaa tagatggtta atatcgaata acgtttattt tcttgaaagt cacggaatgc
     4201 atacggctcg tatcttgagc ctaagcgaga cagctgcaac aggcggttac ggtgcaaatg
     4261 actaatttgc actgtttcta aatccattcc tcgtatgtat tcgagtcgtt ctattatttt
     4321 tagaaaagtt tcgggtgaag gatgacccgg tggctctttt aaccaaccca atatcgtttt
     4381 attggattcg gatggatgct gcgaggtaat aatcccttca agcttttctt tttgctcatt
     4441 tgttagagat ttactaaccg tattaaatag cttcttttca gccattgccc ttgcttccca
     4501 caccattctt tcaagtgtag tgatagcagg cagtataatt ttgttttttc ttagaaaatc
     4561 tatgcattca tgcagtagat gaatggcatc accattttcc aaagctaatt gatgaaggta
     4621 cttaaatgtc attcgatatt cactcagggt aaaagttaca aagtcgtatt cacttcgaat
     4681 ttctttcaaa tgatcccaaa gtgtattttc cctttgagga taatgatcaa gcgaggatgg
     4741 actaacacca atctgtttcg atatatattg tatgaccgaa tctgggatgc ttttgatatg
     4801 agtgtatggc caaccgggat accgaagaac agctaattga acagcaaatc ctaaacggtt
     4861 ttcttccctc cttcgcttat taactatttc taaatcccgt ttggaaaaag tgaagtaggt
     4921 ccccagtatc cattcatctt cagggatttg cataaaagcc tgtctctgtt ccggtgtaag
     4981 caattctcta cctctcgcaa ttttcattca gtatcattcc atttctgtat tttcaattta
     5041 ttagttcaat tatatatcaa tagagtgtac tctattgata caaatgtagt agactgataa
     5101 aatcatagtt aagagcgtct cataagactt gtctcaaaaa tgaggtgata ttttgcggaa
     5161 aatcggttat attcgtgtca gttcgactaa ccagaatcct tcaagacaat ttcagcagtt
     5221 gaacgagatc ggaatggata ttatatatga agagaaagtt tcaggagcaa caaaggatcg
     5281 cgagcaactt caaaaagtgt tagacgattt acaggaagat gacatcattt atgttacaga
     5341 cttaactcga atcactcgta gtacacaaga tctatttgaa ttaatcgata acatacgaga
     5401 taaaaaggca agtttaaaat cactaaaaga tacatggctt gatttatcag aagataatcc
     5461 atacagccaa ttcttaatta ctgtaatggc tggtgttaac caattagagc gagatcttat
     5521 tcggatgaga caacgtgaag ggattgaatt ggctaagaaa gaaggaaagt ttaaaggtcg
     5581 attaaagaag tatcataaaa atcacgcagg aatgaattat gcggtaaagc tatataaaga
     5641 aggaaatatg actgtaaatc aaatttgtga aattactaat gtatctaggg cttcattata
     5701 caggaaatta tcagaagtga ataattagcc attctgtatt ccgctaatgg gcaatatttt
     5761 taaagaagaa aaggaaacta taaaatatta acagcctcct agcgatgccg aaaagccctt
     5821 tgataaaaaa agaatcatca tcttaagaaa ttcttagtca cctgaataat tcatactttt
     5881 aattaaaacc atgtgaaact gcctcacggc agcttacaat tactttttca tcttcacccg
     5941 ttaagtgatg aaaaaagaac ccctttctgc tatggttaaa gtgactaaac caaccaaaag
     6001 aaaggagttc ttttcatgac tagcttacac aaaaaccaag taaaattcaa ttcaaatatc
     6061 actatttctc atacaggtgg tcaattatcg agtgattcgg gtctcgtcct agtgaaagag
     6121 ctgatgaaca tctttggttt ttctgaactg gctaagcaac acattcacat tgaagacgaa
     6181 cgagcgtatt ttactcatga caacttatcc atacttgagc agttcattat gcaattaatt
     6241 gctggttact cagctgattc tgcagctaat ctcctgagac aagatcctgt gtttaaagct
     6301 gttttagata ggaaagaact cgcttctcaa tcttcacttt cccgattttt agatcgacta
     6361 tctgaggaga atatccatga acttcaagct ttgaaccaag aacttatcga taaagcacgc
     6421 ctcatccgta atgatacgga attaatcatt gatttagatt cgacccattc agatacattt
     6481 ggtcaccaag aacaaacgaa ttataataca cactaccaaa cctatggtta ccatccattg
     6541 gtagcttttg acggattgac tggtgacttc ttaaaagctg aactacgttc aggaaatcaa
     6601 tatacatcaa aaggcgtaaa ggagtttctc acacctttat tagagcacta taatcactct
     6661 ctaccaaaca ctgacatctt ggttcgtgga gacagcgggt tcgctacacc tggtgtgtat
     6721 gattcgtgtg aatcaaaaaa gagtcattat gttattcgac tgaagaataa tcgtagacta
     6781 ggtcaaatag ctgagaaatc agtactttat ggcgataatc aaaagtggga agaacgagaa
     6841 gttcagtact tctcgaccac ttatcaagca caatcctggt cacaaagtcg tcgcgtgtgt
     6901 atacgctcaa cacgtgaagc gggcgaacta ctctttcgac atgaatttat cgtgacgaat
     6961 ctatcagaaa atgtttctcc tgataccatc ttttctatct atgccaaacg tggcacaatg
     7021 gagaacttca ttaaagaagc gaaagctggc ttttactttg acaaaacaga cagtcctcgc
     7081 tttttggaga atcatgtccg aatgatgctc agcttgatag cttacaactt agtcaacttc
     7141 ttaagaacga ttggctttga agaagtccaa aagggaatga ccattcattc tattcgattg
     7201 aagtttctga aagttgctgg gaaattagtc caaacgggta gacgagtcta tctcaaatta
     7261 tctagttatc atgtgtatca gaatgaattc tacagggtct ttgctcgcct gaggcgagcc
     7321 agtcaatgga tctaatccaa caatctaacg atttttttac tgggaagtta tccagggaga
     7381 agtatgctca aaatgcctta cacccaaaat ttattcctca atatttttga acagtgaatg
     7441 tttgaagtaa ctttttagtc aaaatcagtt gatagggata ttagtgatac atatttcaat
     7501 aaaatgtgcc aaagaattaa agctatgaat tattcaggag tcatttatta tgtaaatgct
     7561 tataaattcg gccctataat ctgataaatt attaagggca aacttatgtg aaagggtgat
     7621 aactatgagc gataaaatac ttattgtgga tgatgaacat gaaattgccg atttggttga
     7681 attatactta aaaaacgaga attatacggt tttcaaatac tataccgcca aagaagcatt
     7741 ggaatgtata gacaagtctg agattgacct tgccatattg gacatcatgc ttcccggcac
     7801 aagcggcctt actatctgtc aaaaaataag ggacaagcac acctatccga ttatcatgct
     7861 gaccgggaaa gatacagagg tagataaaat tacagggtta acaatcggcg cggatgatta
     7921 tataacgaag ccctttcgcc cactggagtt aattgctcgg gtaaaggccc agttgcgccg
     7981 atacaaaaaa ttcagtggag taaaggagca gaacgaaaat gttatcgtcc actccggcct
     8041 tgtcattaat gttaacaccc atgagtgtta tctgaacgag aagcagttat cccttactcc
     8101 caccgagttt tcaatactgc gaatcctctg tgaaaacaag gggaatgtgg ttagctccga
     8161 gctgctattt catgagatat ggggcgacga atatttcagc aagagcaaca acaccatcac
     8221 cgtgcatatc cggcatttgc gcgaaaaaat gaacgacacc attgataatc cgaaatatat
     8281 aaaaacggta tggggggttg gttataaaat tgaaaaataa aaaaaacgac tattccaaac
     8341 tagaacgaaa actttacatg tatatcgttg caattgttgt ggtagcaatt gtattcgtgt
     8401 tgtatattcg ttcaatgatc cgagggaaac ttggggattg gatcttaagt attttggaaa
     8461 acaaatatga cttaaatcac ctggacgcga tgaaattata tcaatattcc atacggaaca
     8521 atatagatat ctttatttat gtggcgattg tcattagtat tcttattcta tgtcgcgtca
     8581 tgctttcaaa attcgcaaaa tactttgacg agataaatac cggcattgat gtacttattc
     8641 agaacgaaga taaacaaatt gagctttctg cggaaatgga tgttatggaa caaaagctca
     8701 acacattaaa acggactctg gaaaagcgag agcaggatgc aaagctggcc gaacaaagaa
     8761 aaaatgacgt tgttatgtac ttggcgcacg atattaaaac gccccttaca tccattatcg
     8821 gttatttgag cctgcttgac gaggctccag acatgccggt agatcaaaag gcaaagtatg
     8881 tgcatatcac gttggacaaa gcgtatcgac tcgaacagct aatcgacgag ttttttgaga
     8941 ttacacggta taacctacaa acgataacgc taacaaaaac gcacatagac ctatactata
     9001 tgctggtgca gatgaccgat gaattttatc ctcagctttc cgcacatgga aaacaggcgg
     9061 ttattcacgc ccccgaggat ctgaccgtgt ccggcgaccc tgataaactc gcgagagtct
     9121 ttaacaacat tttgaaaaac gccgctgcat acagtgagga taacagcatc attgacatta
     9181 ccgcgggcct ctccggggat gtggtgtcaa tcgaattcaa gaacactgga agcatcccaa
     9241 aagataagct agctgccata tttgaaaagt tctataggct ggacaatgct cgttcttccg
     9301 atacgggtgg cgcgggactt ggattggcga ttgcaaaaga aattattgtt cagcatggag
     9361 ggcagattta cgcggaaagc aatgataact atacgacgtt tagggtagag cttccagcga
     9421 tgccagactt ggttgataaa aggaggtcct aagagatgta tataattttg gctctttgtc
     9481 aaatgatgtt ggtaaagaga aatcttagaa taattggaga tcaagtggat cagttcctct
     9541 tgatcttttt tagttgaaaa tcaatgcgtt gccatgacga atcatgatgc gcaatttgaa
     9601 attataaaag ctacgaaagc catatgcatt tcgttttaac actttgatat ggttgttcag
     9661 acattcaagt gggccatttg aataactttg ttgtaaagca tttttgattt gtggcagaaa
     9721 tttctggaac gttctcaagg tcgtctgata gccttcggga agcatgatat tattggtaag
     9781 tagttcttca aacgatacgt agtctcgttc ctttacagcg taaagaaagt cttgatataa
     9841 ctgatagcct acacgcaaag cagggctccc tttcagtaag cgatccacaa tatcggtctc
     9901 tgttaaatga gctttgaagc caggtcgcca aaggcgtcga gtataatcaa gcttgcgttc
     9961 atctttttga agaagtttcc agtatctttt taattgctta cctaattgat agtgtttttg
    10021 ttctttgctt tttaatagtt ggttcgtttc tttgattcga tgattgcgaa aggtacgacc
    10081 aatatgttgg acgatgtgaa accggtcaat aatcagctgt gcttttggaa acagcttttt
    10141 aacgagcgat acataaggag cgtacatatc aatcacgatc cattcgaccg cttcacgaat
    10201 ttctcgtgaa aaatgactaa aataacgttt taaaaaaggc agttgtcggt tctcgacaat
    10261 gtccaataag cgctgtgttt gtccatccat catgatgaaa ctcatagcac ctgaaacacc
    10321 ccgaactgat ttgaattcat caaaacaaag taccttaggt aacggtgtcc gaaaaggatt
    10381 caacggacga taaaatcgct tcataatacg gtaaacagaa gagaccgata gatttttctg
    10441 agcggcgatc tctgtcattg aggtattttt tttcagacga gtcacgacag accagcggac
    10501 tttctcactg atgaaacaat gttttttcgc aacagaagta tctgcgacaa aggtccgctg
    10561 acaagctttg catttgaagc gttgcttttt caattcgagg taggtacggt attcagaaac
    10621 atcgttcatt aacaaccgga cggttgttgt accccaacgc acaatatctg aagcaatctg
    10681 gtgtttacag tggatgcatt cttgggctgt ataaatcaag tttccacgat aaatatgaca
    10741 gatttgccct ttgtattttt cttttgtgag acaattttcg ttaaaagtaa ctgataagtc
    10801 tagaatatct aatgtttctt tgataaggtg agtgtaagac atcttgattc ctccttttgg
    10861 gttggttcgc caaattaatt ctaaaggatt tcaaggtgtc ttttctatat gttttggaaa
    10921 ataaaaaaga tgctggtgtc atccaccaac atcaaaaagt atagagccat aattttttag
    10981 gaaaatctca aggttatctt tactttttct taggaaatta acaatttaat attaagaaac
    11041 ggctcgttct tacacggtag acttaatacc gtaagaacga gccgttttcg ttcttcagag
    11101 aaagatttga caagattacc attggcatcc ccgttttatt tggtgccttt cacagaaagg
    11161 gttggtctta attatgaata acatcggcat tactgtttat ggatgtgagc aggatgaggc
    11221 agatgcattc catgctcttt cgcctcgctt tggcgttatg gcaacgataa ttaacgccaa
    11281 cgtgtcggaa tccaacgcca aatccgcgcc tttcaatcaa tgtatcagtg tgggacataa
    11341 atcagagatt tccgcctcta ttcttcttgc gctgaagaga gccggtgtga aatatatttc
    11401 tacccgaagc atcggctgca atcatataga tacaactgct gctaagagaa tgggcatcac
    11461 tgtcgacaat gtggcgtact cgccggatag cgttgccgat tatactatga tgctaattct
    11521 tatggcagta cgcaacgtaa aatcgattgt gcgctctgtg gaaaaacatg atttcaggtt
    11581 ggacagcgac cgtggcaagg tactcagcga catgacagtt ggtgtggtgg gaacgggcca
    11641 gataggcaaa gcggttattg agcggctgcg aggatttgga tgtaaagtgt tggcttatag
    11701 tcgcagccga agtatagagg taaactatgt accgtttgat gagttgctgc aaaatagcga
    11761 tatcgttacg cttcatgtgc cgctcaatac ggatacgcac tatattatca gccacgaaca
    11821 aatacagaga atgaagcaag gagcatttct tatcaatact gggcgcggtc cacttgtaga
    11881 tacctatgag ttggttaaag cattagaaaa cgggaaactg ggcggtgccg cattggatgt
    11941 attggaagga gaggaagagt ttttctactc tgattgcacc caaaaaccaa ttgataatca
    12001 atttttactt aaacttcaaa gaatgcctaa cgtgataatc acaccgcata cggcctatta
    12061 taccgagcaa gcgttgcgtg ataccgttga aaaaaccatt aaaaactgtt tggattttga
    12121 aaggagacag gagcatgaat agaataaaag ttgcaatact gtttgggggt tgctcagagg
    12181 agcatgacgt atcggtaaaa tctgcaatag agatagccgc taacattaat aaagaaaaat
    12241 acgagccgtt atacattgga attacgaaat ctggtgtatg gaaaatgtgc gaaaaacctt
    12301 gcgcggaatg ggaaaacgac aattgctatt cagctgtact ctcgccggat aaaaaaatgc
    12361 acggattact tgttaaaaag aaccatgaat atgaaatcaa ccatgttgat gtagcatttt
    12421 cagctttgca tggcaagtca ggtgaagatg gatccataca aggtctgttt gaattgtccg
    12481 gtatcccttt tgtaggctgc gatattcaaa gctcagcaat ttgtatggac aaatcgttga
    12541 catacatcgt tgcgaaaaat gctgggatag ctactcccgc cttttgggtt attaataaag
    12601 atgataggcc ggtggcagct acgtttacct atcctgtttt tgttaagccg gcgcgttcag
    12661 gctcatcctt cggtgtgaaa aaagtcaata gcgcggacga attggactac gcaattgaat
    12721 cggcaagaca atatgacagc aaaatcttaa ttgagcaggc tgtttcgggc tgtgaggtcg
    12781 gttgtgcggt attgggaaac agtgccgcgt tagctgttgg cgaggtggac caaatcaggc
    12841 tgcagtacgg aatctttcgt attcatcagg aagtcgagcc ggaaaaaggc tctgaaaacg
    12901 cagttataac cgttcccgca gacctttcag cagaggagcg aggacggata caggaaacgg
    12961 caaaaaaaat atataaagcg ctcggctgta gaggtctagc ccgtgtggat atgtttttac
    13021 aagataacgg ccgcattgta ctgaacgaag tcaatactct gcccggtttc acgtcataca
    13081 gtcgttatcc ccgtatgatg gccgctgcag gtattgcact tcccgaactg attgaccgct
    13141 tgatcgtatt agcgttaaag gggtgataag catggaaata ggatttactt ttttagatga
    13201 aatagtacac ggtgttcgtt gggacgctaa atatgccact tgggataatt tcaccggaaa
    13261 accggttgac ggttatgaag taaatcgcat tgtagggaca tacgagttgg ctgaatcgct
    13321 tttgaaggca aaagaactgg ctgctaccca agggtacgga ttgcttctat gggacggtta
    13381 ccgtcctaat cgtgctgtaa actgttttat gcaatgggct gcacagccgg aaaataacct
    13441 gacaaaggaa agttattatc ccaatattga ccgaactgag atgatttcaa aaggatacgt
    13501 ggcttcaaaa tcaagccata gccgcggcag tgccattgat cttacgcttt atcgattaga
    13561 cacgggtgag cttgtaccaa tggggagccg atttgatttt atggatgaac gctctcatca
    13621 tgcggcaaat ggaatatcat gcaatgaagc gcaaaatcgc agacgtttgc gctccatcat
    13681 ggaaaacagt gggtttgaag catatagcct cgaatggtgg cactatgtat taagagacga
    13741 accatacccc aatagctatt ttgatttccc cgttaaataa acttttaacc gttgcacgga
    13801 caaactatat aagctaactc tttcggcagg aaacccgacg tatgtaactg gttcttaggg
    13861 aatttatata tagtagatag tattgaagat gtaaggcaga gcgatattgc ggtcattatc
    13921 tgcgtgcgct gcggcaagat agcctgataa taagactgat cgcatagagg ggtggtattt
    13981 cacaccgccc attgtcaaca ggcagttcag cctcgttaaa ttcagcatgg gtatcactta
    14041 tgaaaattca tctacattgg tgataatagt aaatccagta gggcgaaata attgactgta
    14101 atttacgggg caaaacggca caatctcaaa cgagattgtg ccgtttaagg ggaagattct
    14161 agaaatattt catacttcca actatatagt taaggaggag actgaaaatg aagaagttgt
    14221 tttttttatt gttattgtta ttcttaatat acttaggtta tgactacgtt aatgaagcac
    14281 tgttttctca ggaaaaagtc gaatttcaaa attatgatca aaatcccaaa gaacatttag
    14341 aaaatagtgg gacttctgaa aatacccaag agaaaacaat tacagaagaa caggtttatc
    14401 aaggaaatct gctattaatc aatagtaaat atcctgttcg ccaagaaagt gtgaagtcag
    14461 atatcgtgaa tttatctaaa catgacgaat taataaatgg atacgggttg cttgatagta
    14521 atatttatat gtcaaaagaa atagcacaaa aattttcaga gatggtcaat gatgctgtaa
    14581 agggtggcgt tagtcatttt attattaata gtggctatcg agactttgat gagcaaagtg
    14641 tgctttacca agaaatgggg gctgagtatg ccttaccagc aggttatagt gagcataatt
    14701 caggtttatc actagatgta ggatcaagct tgacgaaaat ggaacgagcc cctgaaggaa
    14761 agtggataga agaaaatgct tggaaatacg ggttcatttt acgttatcca gaggacaaaa
    14821 cagagttaac aggaattcaa tatgaactat ggcatattcg ctatgttggt ttaccacata
    14881 gtgcgattat gaaagaaaag aatttcgttc tcgaggaata tatggattac ctaaaagaag
    14941 aaaaaaccat ttctgttagt gtaaatgggg aaaaatatga gatcttttat tatcctgtta
    15001 ctaaaaatac caccattcat gtgccgacta atcttcgtta tgagatatca ggaaacaata
    15061 tagacggtgt aattgtgaca gtgtttcccg gatcaacaca tactaattca aggaggtaag
    15121 gatggcggaa tgaaaccaac gaaattaatg aacagcatta ttgtactagc acttttgggg
    15181 taacgttagc tttttaattt aaaacccacg ttaactagga cattgctata ctaatgatac
    15241 aacttaaaca aaagaattag aggaaattat attgggaaaa atattatcta gaggattgct
    15301 agctttatat ttagtgacac taatctggtt agtgttattc aaattacaat acaatatttt
    15361 atcagtattt aattatcatc aaagaagtct taacttgact ccatttactg ctactgggaa
    15421 tttcagagag atgatagata atgttataat ctttattcca tttggcttgc ttttgaatgt
    15481 caattttaaa gaaatcggat ttttacctaa gtttgctttt gtactggttt taagtcttac
    15541 ttttgaaata attcaattta tcttcgctat tggagcgaca gacataacag atgtaattac
    15601 aaatactgtt ggaggctttc ttggactgaa attatatggt ttaagcaata agcatatgaa
    15661 tcaaaaaaaa ttagacagag ttattatttt tgtaggtata cttttgctcg tattattgct
    15721 cgtttaccgt acccatttaa gaataaatta cgtgtaagat gtctaaatca agcaatctga
    15781 tctttcatac acataaagat attgaatgaa ttggattaga tggaaaacgg gatgtgggga
    15841 aactcgcccg taggtgtgaa gtgaggggaa aaccggtgat aaagtaaaaa gcttacctaa
    15901 cactatagta acaaagaaag cccaattatc aattttagtg ctgaggaatt ggtctcttta
    15961 ataaatttcc ttaacgttgt aaatccgcat tttcctgacg gtacccccaa actaagattt
    16021 catagataga ttttctgata actttaaaaa acacgaatag cggaaaggat gtcttcattc
    16081 gctaaagagt aataaactac ttttccatct tgacgtgatt ttgccattcc atgttttttt
    16141 aaaaaacgta aatggtgtga cgttgtagcg acactagcag taagtatttc tgctaaatca
    16201 cagacgcaca tttccttata ggtttctaaa gcatagaaaa ttttaattct agaaaaatcg
    16261 ctgaaacatt tccctaacac aagtaagttt gaaaaatctt tttgatccaa tttatttttt
    16321 attccattta ctttttcttt atgtacgaca gtcacttggc aaactttttt cattcatctc
    16381 acctcacatt caaacgatta tttgaatgaa gtatacctat ttgatcactc ttttgtcaat
    16441 ctaccttaat tccaatacac tattataagc aatttcatgt attgaagtaa acttacttgc
    16501 aagtgcgttt ttgattccaa gttaaaaaca tattattatt ctacataatt tcctaatcaa
    16561 ataaaactcc tttgaaaatt gttctaaagg agttttatta ttttgtattt ctactaaaaa
    16621 tagcgtacaa tgtaattact aagtaattac gaaatgtaaa ataatggagg aaataatatg
    16681 attacaaaaa caagaaaaca aggaaattct attatgttaa cggtccctaa agaattcgat
    16741 gtgcccaatg gtgttgaagt agaagctaag cttgtagaga atggtatcct ttatgagttt
    16801 gtagagccta aaaaagaatt ttttgatttt agtgaagata ttttggctga tattctttca
    16861 gaaggttata gcaaacaaga gatcttaaaa gaatttagaa atagaaaaaa tgcgttaact
    16921 tctgcattta aatctattgc tgaagatact gttgcaaatt ctaaaccgat gacaaaagag
    16981 gagttggcag cagaaattgg cttatgagat tctaccttct aaacacgtaa taaagtatct
    17041 aaaaaaatta aaagagaaaa cattaaaaga acaattttta acgataattt atgatgagat
    17101 agcagttcgt cctcattcgg gagaacaaaa acgggtgatt tatcaggaat ttgggctatt
    17161 ggattcaagt atgcaggtac gacatatcgc gttgcatatg aaattaaaga taatgcagtg
    17221 atacctatct tactatgtgg aacgcatgaa agatttttat gacctgtata tgattccgaa
    17281 attagaacgt atcgatgaga aaaatttgta taagagtgtt caaggaacat tcaaggaaag
    17341 aaataatcaa tcggtgttta agcatttgta tgatcaggaa atgcctcaat tggtgaaaga
    17401 tgagggcttg agagaaaagt ggaaaagata ccaacaagaa aactattttg ccaaagacat
    17461 ttctttcgaa tctacactaa cttccgttga ttccctgatg caatcaattg tagagcaaga
    17521 gaaggcagaa cgaaaacaaa attttaagag atcacaacaa atgaatcaag aaatggagag
    17581 ataaagatga tcaataatgt aactttagta gggcgattaa ctaaagatcc agatttacgt
    17641 tataccgcaa gtggcacagc agtggcgact ttttccctag ccgttaatcg taatttcacg
    17701 aatcaaaacg gcaatcgaga agctgatttt atcaattgcg tgatttggcg caaaccagca
    17761 gaaacgatgg cgacattagc taaaaaaggc agcttgatcg gcgttgtcgg acgaattcaa
    17821 acacggactt atgacaacca gcaaggacaa cgtgtgtatg tgacagaagt tgtggccgat
    17881 aacttccaac tattagaaag taaagcagcg acagaaagcc gtatgcacgc tgatcaatcg
    17941 tccagcagtc caagccctac cacctttgaa caacgggata cagcgacgcc taacaacaat
    18001 ggattgaacg cttcacagaa tccatttggt ggacaatcaa tcgatattag cgatgatgat
    18061 ctaccgttct aagtagcatt ttctattggt tgcatttgct acggtttatg ttataattta
    18121 gacaacaaaa agaattttca atctataacc aaaaaccact agctggcggg ctagtggctt
    18181 tcttttacgt ttctattata agaattaacg ggtaggctta ctgtctttct tggcaaattt
    18241 acaatcaagc catttgcaga tatagtgcgc ggctacttct gccatgattg caaaaacaaa
    18301 atcaaaaaga attttcaaac ctataacctc ctccccttgc cagattaggc cggggtagca
    18361 gacagcaaga ctattatagc ataattgaaa tatccaaatg attggatttt tgctataatt
    18421 ttagcgaggt gattgtgatg aacaaatatg ttggtttgct tgataaaatc cgagtaataa
    18481 aaacgcaacc gttattggtt cgctttactt tacaaacgat tcatgaatcg attaattgtg
    18541 tagttgcaga tattgaaatt atcgataaat tgctaattat ggatgatgga aaatacaata
    18601 ttgccgtcac aggtcacttc aataaacgaa atcagctagt tattgctagc atgtatgtta
    18661 gaaatcccga tcattttacg cgatcgatgg gcatataaat aaaagaagag ttgtagtcct
    18721 aaatgaggat tgcagctctt tttgttttac atagaaacag gaaaagacct ttttaggaag
    18781 acacaagtgc cttctcaatt gaaaaacctt tctctcactc caaccgccac cgccgttcga
    18841 gaagaaagga agtgaacgct gcacgttcac taagatatgg tgtcttgcaa agcaagacaa
    18901 aatagacaaa acttcctctc accaaaaggt tcgttcctgt tcgttatctc tttattgatt
    18961 tgccagaccg gcaacaagtt gccttttatc accaaaaagc gacaaggaca agggtaaatg
    19021 gcacgctgcg cgcccttgtc cttgtcgctt ttcgttgatt tattctggcc aacaaatcaa
    19081 taaagaaaga actaacgaaa ggaagtaaaa cctttcctaa gaggaggcag aatcaaacat
    19141 gcgaaagaaa tttgattatt ggggtgttcc cttcagcgaa ttattcccaa actatcatgc
    19201 accacatact gttgaatgcg attgtggaga aagagcgaaa tgtatcaaaa gctatcgttt
    19261 gtatcaatgt ccaacatgcg ggaaaaaata taccttgtct tatggcgatt acattttgat
    19321 tgatgagaaa ggaaagaaac gctgatgaaa acacaacaca aattattgac tgtaaaagaa
    19381 gtcgttcaaa ttttggtgga caaagaagtc atttctgaaa aagtagcaga agctttactt
    19441 attccgcggt actggacgat agaaacccct ttagtagagg atgcaccgac tatgctattt
    19501 gaagacctag tgaagattgc aggatatgaa ctgcattatc aagaaaacat ggaaacttat
    19561 gaaatcgaat attggttaac caaattagag aactaaaaag gagaaaaaat atggctcaaa
    19621 attactatga cgaatttgtc aaattacctt tggataaaat ggcacaaaaa atggaggata
    19681 tgacgttcct ataccatgaa acacgtgtac ccaaaaaaca ttacaaggaa aaattgtcag
    19741 tcgcagtgga agaaatgatt gaatcaggtg tcgaaatgaa tctcattgcg acgtactatc
    19801 gaacactgga agaactgaaa aaacaaaatg gaaaatggtt tttccaagcc ttactatgct
    19861 tggaagtagg tgtcaaacca agcactatca aaccttccga atatcaagcc ttagaactga
    19921 cttatgcaaa attcgcacag attaagaaag ctaaagcaat ggctagcgac tggctagata
    19981 cttttgaaag tatcgaaaaa aatggtgcat tttatacgat tgaatcggag gagaaagata
    20041 atgaataagg tggtttatca gctaacaaca gaagatgttt cgcaattttt aacagacaaa
    20101 gaacacttga atgaagtaat cagacggatt caaaaagact ttagttgtat ggaagaaatg
    20161 aagtacttta ttcaaagagt ggaagaacag ttgtatatgg aaagcgaaac aagtcaaacg
    20221 aaggtcacag tcagccataa tcatttagac gtgtataaac gtcgtcctga aacggtaaaa
    20281 aaaggaacag agcttctacg actagaaaca gaaaaataca tcatgaatgt gtacctagaa
    20341 aggagtgagc tggtcgaaaa ctttgtcagc tacacgattt gtaggaaaca ctattactca
    20401 gaatcagaat attattcaat tttcgagagc atggaattaa tggaagaaga aatggaagag
    20461 ctaaacagca aaaatgcgac ggtagacgat tattaccttg tatttactag gtttttgacg
    20521 tgtgggacgg aatctatcgt gttaatggga atggattatg aactcgctgt acccgaagca
    20581 tttttgaggg aatatgtaga agaagtagat aacccaggcg acgactggta cacgacttta
    20641 actgattttt tagacaccta cacttacgac gatacagaag aaatccaaaa tgaacttgac
    20701 cgtaaacgaa tgccatatca acgatttgaa aggaaaaaag gtaaataacc atttataccg
    20761 aaaagtgagg atgtgtgaaa taagaacaaa aaaccttgaa attaagggaa tggttcttat
    20821 ttcgcaccaa tcgctccaac cgcccccgcc gcttaggtgg tgcgaaataa gcgggcaaag
    20881 cccgataacc taagagaaag aaggagatcc atatgaataa aatcattcct ctattgttcg
    20941 tactgtttgt tggcgagata cttatgcgtc atgctgcagc tgtacattta aacttcgtag
    21001 tattcttagg aatactggta ttttgtttga tcttttggcg atttgtatta gcccttgtga
    21061 gtctactatt caagatgatt gcagccatat ttttcatagg gttatttcga tgaaaggaga
    21121 gagtactaat gccaattgca ataggaaata aacggttacc cgtgacatta gatgaaaaga
    21181 gacaaaaaga attgcagcaa ctaaagcaga agtacggaaa aagtgaatct aagattatgt
    21241 gtattgcgtt agatctattg atcgcgcaag aaaaagcagg atttgatata ccagcactaa
    21301 aaaagtgacg tcacttttca tttgaagaaa caaaagtgat agcacttaat tgttcctact
    21361 atttagaata ttttctatgt cctttttatt ccattttgta tcaataacta tgaaatcttt
    21421 aaagtatcca gaagagatta tttttagatc aatttttttc ttacctgatt ctaaagattt
    21481 tgttttctta aacatattat gatttccttt cgactatttt catataaatg ttaacatagt
    21541 ttatggattc atggaatgtt aatctaattt aatagaaaag gataattaag tatatacgtt
    21601 ttttcttatg tatgttatac tatgtatata cagaaagagg tgtctactat ggaaatgtta
    21661 cctataaaaa aatggggaaa tagtaatggc cttagattgc caaagtatat tatggaatat
    21721 cttggaattc atacagaaga caaagtgaag ataatacaag aagaagtaaa cggtcagaag
    21781 cggctaatta tcgaagcggc taatatagaa aatgaattaa caattgaaca gttatttgaa
    21841 aattacactg atgaaagaaa tcatgtgacg attcaaaatt taggtgaagc agtaggtaat
    21901 gaaaaatggt gagaaaacct agacaaggcg atattctatt attgaataca gcacctcgat
    21961 ctggacacga acagacaggt aaaagacctt atattgtttt aagtcatgat attattgcgg
    22021 attatagtaa cgttgttaca gttgctccaa tttctagtac aactagaaac tatccgctat
    22081 atgtaaatat aaactcagaa tatgaaatga agacaacagg aaaagtatta ttagatcaac
    22141 taacgacaat tgattatgaa gccagagagt gtattttttt ggaaaaagcg catgatagtt
    22201 tagttgagga gttattgatg aaagttagaa cagtttttca aaaagtaagc aaataaaata
    22261 gaaacagcag catgatcaac tattcgtgat tgaccatgct gtcttttttt attctataca
    22321 cggtttgtct cgtaacattg tagtcttttg caatcttagc gatcgcaaca ccttttttta
    22381 gatcctcaac gatgttttta taaacaagac gacgttgggg atcttttgca ttggcactgt
    22441 atagcttagg acgtccttta taaacaccgt tcgcttttgc aatcttaatg ccttgtgcct
    22501 ggcgacgttt cgattcggta cgttcttgtt cagcgatcat ggccaaaatt tggatgatca
    22561 gatccttaat gaatttatcc aggagaggat tgccaattgc ttcagccatg atcggtaaac
    22621 tagtaatgat cagcttcaca tttttcttct tcaagtaatt gactgaagcg atgatctcgt
    22681 cataatttct tccaagtcga tcaatagctt ccacaataaa aatatcttga tctcggacgt
    22741 aatctaatgc ttcttggaaa acaggtcgat gagtaatcgt tgcgccagat tgtttctcga
    22801 tgaaaattct ctctgcaccg aattttttca tttcttcaat ctggcgttgt tcattttgat
    22861 cgatggatga gacacgtatg tatgcaactc tcaaaacttt tacctacttt ctgcaactat
    22921 ttaaaataca ccctaatcat acacgaggaa gccatatttt tcaatgttat accagtgtct
    22981 atttagggta aaccttatat agacaaaaac taatgatgga ggaaatagta tgagaatttt
    23041 ttgtaagtgt ctactgataa cttattctca aatgttgtaa ggattttatt catttgttaa
    23101 tattaaagaa cggaactcca aaaaagtccg tactctaatt tgcagtctct cactctttta
    23161 gagtgagagt ttttattaga ttttcaaatt aattagtaaa gtgatagaat aaattgatca
    23221 tacaaatcaa aagaagaagc agggtgatag catacctatg cttctttttt tatgtattta
    23281 gctatttctt ctttacaata tcgaacatat gtttgtataa tgtgaaagaa tggagtgtta
    23341 tttatgatgg attattcaaa agagccagta aatgattact ttttaatcga tatgaaaagc
    23401 ttttacgcaa gtgtcgaatg tatagaaaga aatttagatc cattaacaac agaacttgtt
    23461 gttatgagtc gagctgataa tactggttca ggattgatat tagcttcttc tcctgaagca
    23521 aaaaagcggt atggtattac aaatgtgagt agaccacgtg acttaccaca accatttcct
    23581 aaaacactac acgttgttcc accacgtatg aacctatata tcaagcgaaa tatgcaggta
    23641 aataatattt tcagaagata tgtggctgat gaagatctac tgatttactc gatcgatgaa
    23701 tcaatcttaa aagtgacccg atcactgaat ctttttacga ctgaaggaac acgaagtcaa
    23761 cggagaaaga agctggctca aatgatccag gagaatatta aagaagagct aggattgatt
    23821 gctacagtag gtgtcggaga taatcccctt ttggctaaac tagccttaga caacgaagca
    23881 aagcataatg aaggatttgt tgcggaatgg acgtacgaaa acgttcctga aaaagtatgg
    23941 aatattcctg aaatgacgga cttttgggga attggctctc gaatgaaaaa aagactcaat
    24001 cagatgggga ttatgagcat tagagatctt gctaactgga atccttatac gattaagaat
    24061 agactaggtg tgattggctt acagctgtac ttccatgcta atgggatcga tcgaacagat
    24121 atagcaatcc caccagaacc gacaaaggaa aaatcatatg gaaattcaca agtgttacca
    24181 cgagattata ctagaagaaa tgaaatcgag ctggtggtaa aagaaatggc ggaacaagta
    24241 gcgatacgca ttaggcagca taactgtaaa acaggttgtg tccatttaca cattggcacg
    24301 tcgatcttag aaacgagacc agggttttca caccagatga agatccctat cacagataat
    24361 acaaaggaat tgcagaatta ttgtcttttc ttgtttgata agtattatga aggacaagaa
    24421 gtaaggcatg ttggaataac ctatagcaag cttgtgtaca ccgattcgct tcagctggat
    24481 ttatttagtg atccacaaaa gcaaattgac gaagaaaatt tagataaaat tattgacaag
    24541 attcggcaaa aatatggttt tacgtcgatt gtacatgctt cttcaatgtt agaaggcgct
    24601 agaagcatta ctagaagcac acttgttggt ggtcatgcgg gcggaaatgg gggaattaaa
    24661 aatgattgat tacaatgatc gtggacgttt aaagtgggca gggttttatt tatctgatca
    24721 tactgaagaa attgatgccg acaatgaaca acgtgcaaat cataatttgg caaaagaaca
    24781 aatgacgact gaagagattg cggaagtatt gaacgctgca gtcataaaaa atagatcagt
    24841 atctattcaa aaagaagaac gaaacgctga aggatactat ccagaagata tcattggcaa
    24901 gatcttaggt agtgatgagc tggggatcta cgttggaaaa gacaaaattc actacgacga
    24961 aatacgtcat atcgaatttt accaggataa taaatggagt cgattagaat gaacattatc
    25021 cagcaatatg agctaaagta tataaccttt gatcagctat cagaagagat ttggggttat
    25081 ggccaacgtt tgataaatga ggttggtgtt gagcgcttct ctttctatgt agaagctgca
    25141 gcaggttatc ataattttag gttttatatc ttcccgttat atatataagg tattttacgg
    25201 attctataga gttatctcta tgaatccttt tttgttttta caaataggag tagatactag
    25261 aataatgcgt gtgttaaact attattgcaa acgcaataat aaaagaaagt aggcttacgc
    25321 accatgtcta tcaatacatt tgtttactcg cacccgatca atgtttacat tatcaagaat
    25381 ttaggaatca ctgtagaaca attttgtgag ttatatgcct acccacaagg aacggttgca
    25441 agctggataa cccgacaacg tagaatcaaa tcactacctg cttcatttat atatgatctg
    25501 agtcttgctt ctagttgcaa catgtctgat gtctatgaaa aattattgat actagagaat
    25561 gagtacgatc aatttaattc caatcaaaaa aagaaaaaga aaaaacacat agattaatat
    25621 tgaaacgaaa aatagtattt attttaaaaa aagagaaagt agaaaaagat atttttccat
    25681 tatttgatta aagttacttt taatcaaaac tattgtaaaa tagtacttgt tttatgtatc
    25741 ttaaaatcaa aaaactttga ttaaagattc ttcaatcaaa aaaacttaaa aacattgata
    25801 taatagcatt taataaaaat aagtatctcg taatcaaaaa aataatttga ttacgagata
    25861 cttatttaca tttacaacag caagttgtat acttaatttg aataaaagat acttaatcaa
    25921 aaggagcgta ataatatgaa tgcaaattca atagtagttg gtaattttaa aggaggaaca
    25981 ggaaaatcta cttctactca aatgctaggc tttgtaaatg cattttacaa aaaaagaaaa
    26041 acattgctta tagatcttga tccacaagca aatgcttcag aagttatgag tttcactgct
    26101 gacaacttag ggaatcattt ttatcaagaa aatgggtttc ctaaaactat atggaatgtt
    26161 ctttacgacg gtagtttaga cggcgctgtc cttcccctaa ttgaaaattt agatttaatt
    26221 gccggtaata ttgctatgag tgactactct gattttatga gcgctaaatt tccaaacgat
    26281 aaattagctc aatttgagta ctttgcgaac attctagcac ctttaaaaga agaatatgac
    26341 gaaattttca ttgatgtacc accttcactc ggaactattg tacagagtgc aatgtacttt
    26401 gctgaatatg tagctattat gcttcaaaca cagccaaaat caattagagg ggctgctgat
    26461 tatatagatt atatggaatt tttcactgaa agatataata cacaactagg tattgctgga
    26521 attattccat ttatgttaga cacaaaaaca agtacagaaa gctatatgta caatgaagct
    26581 aaaaagttat atggcgataa ccttatcaac acaatcgttt tcagaagtgc tagattgatt
    26641 agatacgatg aaactggtat tacattagaa acaaagaaaa atggggagct taaaaaagta
    26701 gacgcaaatc cacagaatac tttcatatct attttagacg aactaaatga acatattagt
    26761 tggtttgagg aggaataaag atggctgaaa gacaatcaaa actatttcct aacaagaaag
    26821 cacgtccaag aacgaatggt atgaaagata tggaagaatt tacaaaatct ttatctatat
    26881 cttcagctga taattccgct cctaaagtta atacaacaga aaaacattct gatgataaca
    26941 agaatctaaa aaatccaaat aaaagtcata aaggtaaagc tggcagaaaa gctgaataca
    27001 aagatccaag actaaaaaag gatttgaata caaaaatctc tttaagtacc aaattaagaa
    27061 tccaacgcct tatttcaagg aaatttgata ataaatctga aggtgatgta attgatattg
    27121 ctcttgatta tttggtatct tcatttgata gagacgatag agattcattg tataaagcat
    27181 acaaggaaga catggagtca atgataccaa ttattcaaga aaaaaatgaa aaagctaaaa
    27241 aacaaggtaa actaacacta gatatcaccg atgaaataaa tcaacaaact ttaaaagaac
    27301 aaaaagaaaa atgggtatca gctaagtttg aatagaagat acttaaaaca acataaacta
    27361 ttgattgaag tatctggtaa tattgatttt aagatacctc aatcaatagt tttttcttta
    27421 aaataagcat ttatgtttga ataagagata ctaaaatcaa ataaaagtat cttttaatca
    27481 acaaactagt ttgaataaag ttactcataa tcaaattata aatgattttt agatactaca
    27541 atcagataga aaccctatta aattaacttt cttaattgat taaaagatac taaaatgaga
    27601 ttattttgat tttagtgcca aaaaacaaac taaaattttt gattttagta tccttaaatc
    27661 aaattaaatg tatattacga gtcactataa tcaaaggtaa tttattacga atattgtctt
    27721 ctcaataaaa agttcttgat tataagatct ttcaatcaga tttatttttg aataaggtgt
    27781 cttccaatca aaagtaataa ctgatttaag tatctcttat tcaaaatata gttgtctgaa
    27841 aataataaac tgttaaactt attttgaagc ctatattatt cctgatttgt atatcgaaat
    27901 tcattagcta tatacattta aagaaatcta attatatttt tgataataaa aattgtacgg
    27961 atactagaaa agagggagtt taatgtctac agaatttcaa tctcaaaaaa tg
//
