LOCUS       NZ_CP125868            20966 bp    DNA     circular CON 01-MAY-2024
DEFINITION  Staphylococcus aureus strain 19-02247 plasmid p19-02247_1, complete
            sequence.
ACCESSION   NZ_CP125868
VERSION     NZ_CP125868.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN35074235
            Assembly: GCF_038789195.1
KEYWORDS    RefSeq.
SOURCE      Staphylococcus aureus
  ORGANISM  Staphylococcus aureus
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 20966)
  AUTHORS   Schuermann,J., Fischer,M.A., Reemtsma,T., Karte,J., Staerk,H.-J.,
            Strommenger,B., Werner,G., Layer-Nicolaou,F. and Schuster,C.F.
  TITLE     The genes mgtE and spoVG are involved in zinc tolerance of
            Staphylococcus aureus
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 20966)
  AUTHORS   Schuermann,J., Layer-Nicolaou,F., Schuster,C.F., Fischer,M.A. and
            Werner,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-MAY-2023) Unit 13: Nosocomial Pathogens and Antibiotic
            Resistances, Robert Koch Institute, Burgstr. 37, Wernigerode 38855,
            Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 23-MAR-2023
            Assembly Method                   :: Unicycler v. 0.5.0
            Assembly Name                     :: 19-02247_RKI_Sau
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 111.0x
            Sequencing Technology :: Oxford Nanopore MinION; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_038789195.1-RS_2024_04_30
            Annotation Date                   :: 04/30/2024 23:48:17
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,885
            CDSs (total)                      :: 2,803
            Genes (coding)                    :: 2,721
            CDSs (with protein)               :: 2,721
            Genes (RNA)                       :: 82
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 82
            CDSs (without protein)            :: 82
            Pseudo Genes (ambiguous residues) :: 0 of 82
            Pseudo Genes (frameshifted)       :: 44 of 82
            Pseudo Genes (incomplete)         :: 41 of 82
            Pseudo Genes (internal stop)      :: 17 of 82
            Pseudo Genes (multiple problems)  :: 19 of 82
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP125868.1.
            Bacteria and source DNA available from Robert Koch Institute, Unit
            13 Nosocomial Pathogens and Antibiotic Resistances, Burgstr. 37,
            Wernigerode 38855, Germany.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..20966
                     /organism="Staphylococcus aureus"
                     /mol_type="genomic DNA"
                     /strain="19-02247"
                     /host="Homo sapiens"
                     /db_xref="taxon:1280"
                     /plasmid="p19-02247_1"
                     /geo_loc_name="Germany"
                     /collection_date="2019"
                     /collected_by="Robert Koch Institute"
                     /genotype="ST3586"
     gene            complement(11..160)
                     /locus_tag="QM318_RS14295"
                     /old_locus_tag="QM318_14295"
     CDS             complement(11..160)
                     /locus_tag="QM318_RS14295"
                     /old_locus_tag="QM318_14295"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000695367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000695366.1"
                     /translation="MKIKTFATFTHRQLDKQVNRFLKNDIHVLEIQTHSNWLYISAIVF
                     YEDK"
                     /name="hypothetical protein"
     gene            complement(707..>996)
                     /locus_tag="QM318_RS14300"
                     /old_locus_tag="QM318_14300"
                     /pseudo=""
     CDS             complement(707..>996)
                     /locus_tag="QM318_RS14300"
                     /old_locus_tag="QM318_14300"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009384749.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="protein rep"
                     /name="protein rep"
     gene            complement(1016..1999)
                     /locus_tag="QM318_RS14305"
                     /old_locus_tag="QM318_14305"
     CDS             complement(1016..1999)
                     /locus_tag="QM318_RS14305"
                     /old_locus_tag="QM318_14305"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /protein_id="WP_001181107.1"
                     /translation="MQNQYFTVQENYKERFYQIPKVFFTSENYKNLTNDMKIAYAILRD
                     RLNLSIKNSWVDEDGNIYFVYSNEKLMEILNCKKEKLTKIKKGLENDGLLIQKRRGLNK
                     PNILYLMKPIVTERDIYKIEKEENDVEPYGEKEVRKSNVQKFENRTSRSSKIERPEVRK
                     SNTNDTDFNDIDFNDTENNDMNDLNDIKYKNEISNHSNHSNQFTHNFDDKEMLLQEFPE
                     QLTNYLLKYDYRDLEIIKAVILKAKKSFNSRHEDMHYMLEDIEDEILTSLKRLKKAIHD
                     RGVKGQKETIKSMQAYLMQTILTELEETHALYMRRKNMKQYNIFNQ"
                     /name="replication initiator protein A"
     gene            2425..3168
                     /locus_tag="QM318_RS14310"
                     /old_locus_tag="QM318_14310"
     CDS             2425..3168
                     /locus_tag="QM318_RS14310"
                     /old_locus_tag="QM318_14310"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000843735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /protein_id="WP_000843732.1"
                     /translation="MKSVKKLSEELGVSKQTIFNNIKRLNIETIKQENTSFIKEDTDIE
                     KIIQRVNENKKKYGFESTTEDKQKKGSDNINFESKSDAQIVEILKNQIDTLNNQIEKQE
                     SRHETTIEFYRKELQERSKLLENQQVLALESNKKIQKLENQLEKEKHLNYPFDTSTNTR
                     QNVDAQEKTYTTNPVNINRDQEETKETEIQYKDISGSQSDESTQGEEAKKEDVPANLND
                     NDSDIEEKSEETEPKKGFWSRLFGS"
                     /name="DUF536 domain-containing protein"
     gene            complement(3395..3580)
                     /locus_tag="QM318_RS14315"
                     /old_locus_tag="QM318_14315"
     CDS             complement(3395..3580)
                     /locus_tag="QM318_RS14315"
                     /old_locus_tag="QM318_14315"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011276570.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_000797248.1"
                     /translation="MKNRIREYRKQKGISQETLSKELKVSRQTINAIENNKYDPTLTLA
                     FKLARLFDTTVDELFS"
                     /name="helix-turn-helix transcriptional regulator"
     gene            complement(3585..3923)
                     /locus_tag="QM318_RS14320"
                     /old_locus_tag="QM318_14320"
     CDS             complement(3585..3923)
                     /locus_tag="QM318_RS14320"
                     /old_locus_tag="QM318_14320"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001049146.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001049146.1"
                     /translation="MNLIPFIIILIFSCLWTAITNKYLPSETLDKKGQQDRYDERQRKM
                     FIEILAKSFIWIVYCMLFTLVLKFTGLSPSIEGSWFSQYPEIFFIIVALFLMLFNYYTT
                     NKKYTSKG"
                     /name="hypothetical protein"
     gene            complement(4169..4777)
                     /locus_tag="QM318_RS14325"
                     /old_locus_tag="QM318_14325"
     CDS             complement(4169..4777)
                     /locus_tag="QM318_RS14325"
                     /old_locus_tag="QM318_14325"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002474535.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_000583528.1"
                     /translation="MIIGYARVSSIDQNLERQLDNLKTFGVEKIFTEKQSGKSVENRPV
                     FQEALNFVRMGDRFVVESIDRLGRNYDEIIETVNYLKEKDVQLMITSLPMMNEVIGNPL
                     LDKFMKDLIIQILAMVSEQERNESKRRQAQGIQVAKEKGVYKGRPLLYSPNAKDPQKRV
                     IYHRVVEMLEEGKAISKIAKEVNITRQTVYRIKHDKGLS"
                     /name="recombinase family protein"
     gene            complement(5263..6162)
                     /locus_tag="QM318_RS14330"
                     /old_locus_tag="QM318_14330"
     CDS             complement(5263..6162)
                     /locus_tag="QM318_RS14330"
                     /old_locus_tag="QM318_14330"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000196697.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Mph(C) family macrolide 2'-phosphotransferase"
                     /protein_id="WP_000196697.1"
                     /translation="MTRHNEIIKCAEKYQLHIQPQTISLNESGLDFQVAFGKDKHGVEW
                     VLRLPRRPDVYKRTKPEKQTVDFLQKNVSFEIPKWKVHAKDLIAYPKLTGKPAATIDPE
                     IQNYVWEIEHKPLPENFINTLAETLVDLHNIPEENINVQHINIKTIQEIKNDFQRRMNK
                     VKETYGVSDELWNRWKQWLENDELWPRHATMIHGDLHPGHIMVDNQANVTGLIDWTEAT
                     HSDPSMDFIGHHRVFDDEGLEQLITAYGKAGGEIWPRMKEHIIELNAVFPMFIAEFAME
                     SGESAYETMALKELGMKE"
                     /name="Mph(C) family macrolide 2'-phosphotransferase"
     gene            complement(6261..7727)
                     /gene="msr(A)"
                     /locus_tag="QM318_RS14335"
                     /old_locus_tag="QM318_14335"
     ARG             complement(6265..7727)
                     /name="msr(A)"
                     /gene="msr(A)"
                     /gene_name="ABC-F type ribosomal protection protein Msr(A)"
                     /tool="amrfinderplus"
                     /drug_class="MACROLIDE/STREPTOGRAMIN"
                     /identity="100.0"
                     /coverage="100.0"
     gene            8201..8875
                     /locus_tag="QM318_RS14340"
                     /old_locus_tag="QM318_14340"
     CDS             8201..8875
                     /locus_tag="QM318_RS14340"
                     /old_locus_tag="QM318_14340"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6 family transposase"
                     /protein_id="WP_001105960.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TIYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDTEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVVTDQAPSTKAAMAKIIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6 family transposase"
     gene            9453..>9928
                     /locus_tag="QM318_RS14345"
                     /pseudo=""
     CDS             9453..>9928
                     /locus_tag="QM318_RS14345"
                     /inference="COORDINATES: protein motif:HMM:NF024676.4"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="WYL domain-containing protein"
                     /name="WYL domain-containing protein"
     gene            complement(9987..10661)
                     /locus_tag="QM318_RS14350"
                     /old_locus_tag="QM318_14350"
     CDS             complement(9987..10661)
                     /locus_tag="QM318_RS14350"
                     /old_locus_tag="QM318_14350"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS257 family transposase"
                     /protein_id="WP_001105991.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TVYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDAEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVITDQAPSTKVAMVKVIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6-like element IS257 family transposase"
     gene            10923..11108
                     /locus_tag="QM318_RS14355"
                     /old_locus_tag="QM318_14355"
     CDS             10923..11108
                     /locus_tag="QM318_RS14355"
                     /old_locus_tag="QM318_14355"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001037130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001037130.1"
                     /translation="MNKLEKWSLVFIIFTFLSSLALLYFKYNFSSVMPVLSLSILTILI
                     LLTSIITVVSVNDEDT"
                     /name="hypothetical protein"
     gene            complement(11331..11909)
                     /locus_tag="QM318_RS14360"
                     /old_locus_tag="QM318_14360"
     CDS             complement(11331..11909)
                     /locus_tag="QM318_RS14360"
                     /old_locus_tag="QM318_14360"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690624.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_000690637.1"
                     /translation="MKIGYARVSTGLQNLNLQEDRLNTYGCEKIFNDHMSGSKSKRPGL
                     DKAIEFARSGDTIVVWRLDRLGRNMEDLITLVNELNERGVSFHSLEENITMDKSSSTGQ
                     LLFHLFAAFAEFERNLILERSSAGRIAARARGRYGGRPEKLNKQDLNLLKTLYDNGTPI
                     KTIAEQWQVSRTTIYRYLNKLEAKENKNK"
                     /name="recombinase family protein"
     gene            complement(12173..12553)
                     /gene="blaI"
                     /locus_tag="QM318_RS14365"
                     /old_locus_tag="QM318_14365"
     ARG             complement(12177..12553)
                     /name="blaI"
                     /gene="blaI"
                     /gene_name="penicillinase repressor BlaI"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="98.41"
                     /coverage="100.0"
     gene            complement(12543..14300)
                     /gene="blaR1"
                     /locus_tag="QM318_RS14370"
                     /old_locus_tag="QM318_14370"
     ARG             complement(12547..14300)
                     /name="blaR1"
                     /gene="blaR1"
                     /gene_name="beta-lactam sensor/signal transducer BlaR1"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="95.38"
                     /coverage="100.0"
     gene            14407..15252
                     /gene="blaZ"
                     /locus_tag="QM318_RS14375"
                     /old_locus_tag="QM318_14375"
     ARG             14408..15249
                     /name="blaZ"
                     /gene="blaZ"
                     /gene_name="penicillin-hydrolyzing class A beta-lactamase
                     BlaZ"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(15778..16197)
                     /locus_tag="QM318_RS14380"
                     /old_locus_tag="QM318_14380"
     CDS             complement(15778..16197)
                     /locus_tag="QM318_RS14380"
                     /old_locus_tag="QM318_14380"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000418034.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_000418035.1"
                     /translation="MELDNCINYLLSTSQNRVFKHFKSLLSPYNITPAEYGVLNCLINS
                     NLNTPKAIGNTLNLEPSTISGILDKMSKKDLITRQTDNENRRTVLINSTNKAKDLWPTL
                     EKKAYQLNNHYFANLTNEETVVFKKILLKINKTTF"
                     /name="MarR family transcriptional regulator"
     gene            16321..17292
                     /locus_tag="QM318_RS14385"
                     /old_locus_tag="QM318_14385"
     CDS             16321..17292
                     /locus_tag="QM318_RS14385"
                     /old_locus_tag="QM318_14385"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000481285.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oxidoreductase"
                     /protein_id="WP_000481279.1"
                     /translation="MFNAVVVRKSASNVSYKVEKVDESHLSKGDVLVKVVYSSINYKDM
                     LALQYKGGVIRDYPMIPGIDFAGIVESSSNDKFKEGDNVLVTGYDVGVTHTGGFSEYAQ
                     VPGEWIVPIPQEMSIKESMVYGTAGFTAALSIFELEKYGMNIKSQPEILVSGATGGVGS
                     VAIQILHKIGYENITAIVRKEKQIEIAKKLGAKQVIIIEDDNKPLKKGIFDYFLDTVGS
                     NVTLYGLKRLNYQGVATVCGNVAGNSLNANILPFILRGIKLIGIDSVYVDHNIREDIWS
                     KLANEWNIGNSLLYNEIGFEEFYKTIDQLLKGQHLGRTILKV"
                     /name="oxidoreductase"
     gene            complement(17464..17556)
                     /locus_tag="QM318_RS14390"
                     /old_locus_tag="QM318_14390"
     CDS             complement(17464..17556)
                     /locus_tag="QM318_RS14390"
                     /old_locus_tag="QM318_14390"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002495832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="WP_001791613.1"
                     /translation="MLIIFVHIIAPVISGCAVAYYTYWLSKRNK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            complement(17713..18060)
                     /locus_tag="QM318_RS14395"
                     /old_locus_tag="QM318_14395"
     CDS             complement(17713..18060)
                     /locus_tag="QM318_RS14395"
                     /old_locus_tag="QM318_14395"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020366422.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_000119690.1"
                     /translation="MSYENTCDVICVHEDKVNNALSFLEDDKSKKLLNILEKICDEKKL
                     KIILSLIKEDELCVCDISLILKMSVASTSHHLRLLYKNEVLDFYKDGKMAYYFIKDDEI
                     REFFSKNHEGF"
                     /name="metalloregulator ArsR/SmtB family transcription
                     factor"
     gene            complement(18079..18696)
                     /gene="cadD"
                     /locus_tag="QM318_RS14400"
                     /old_locus_tag="QM318_14400"
     ARG             complement(18083..18696)
                     /name="cadD"
                     /gene="cadD"
                     /gene_name="cadmium resistance transporter CadD"
                     /tool="amrfinderplus"
                     /drug_class="CADMIUM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(19813..20007)
                     /locus_tag="QM318_RS14405"
                     /old_locus_tag="QM318_14405"
     CDS             complement(19813..20007)
                     /locus_tag="QM318_RS14405"
                     /old_locus_tag="QM318_14405"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001004925.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001004925.1"
                     /translation="MNENLEKYIKSLPLLGLLISILLIVLFFFILDVDEDLFVVFLYCL
                     LPLIVNLSIYGFYVFVKRK"
                     /name="hypothetical protein"
     gene            20117..20809
                     /locus_tag="QM318_RS14410"
                     /old_locus_tag="QM318_14410"
     CDS             20117..20809
                     /locus_tag="QM318_RS14410"
                     /old_locus_tag="QM318_14410"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000691527.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative immunity/bacteriocin fusion bifunctional
                     protein"
                     /protein_id="WP_000691527.1"
                     /translation="MKIIKLFSIISLFLLVFSANFSNAYANEEQKSSLLENQKEKLKSK
                     NIEVSQMTKKEISFLEQLQNKNEDMQKFEKQMKKEGFKKIKLEDKNSKLKYLATEANDK
                     NAYGYIANNAYKNEKTKEIVVSETIYDNYNKKITKFIAEKRSMTENKEGKILINKNYVE
                     YKAEKVDKNRPVTYAGFKWNGKAFACSMAGLYACAHYCGVWAIVNPIAGGVCEAVCGTA
                     FAAGCSVG"
                     /name="putative immunity/bacteriocin fusion bifunctional
                     protein"
     ARG             complement(5267..6162)
                     /name="mph(C)"
                     /gene="mph(C)"
                     /gene_name="Mph(C) family macrolide 2'-phosphotransferase"
                     /tool="amrfinderplus"
                     /drug_class="MACROLIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             complement(6262..7727)
                     /name="msrA"
                     /gene="msrA"
                     /gene_name="msr-type ABC-F protein"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic; streptogramin
                     antibiotic; streptogramin B antibiotic"
                     /identity="98.36"
                     /coverage="100.0"
     ARG             complement(5264..6162)
                     /name="mphC"
                     /gene="mphC"
                     /gene_name="macrolide phosphotransferase (MPH)"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic"
                     /identity="98.66"
                     /coverage="100.0"
     ARG             14408..15252
                     /name="PC1 beta-lactamase (blaZ)"
                     /gene="PC1 beta-lactamase (blaZ)"
                     /gene_name="BlaZ beta-lactamase"
                     /tool="rgi"
                     /drug_class="penam"
                     /identity="96.8"
                     /coverage="100.0"
     Typing          complement(504..651)
                     /name="MOBQ"
                     /typing="oriT"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="5.980000000000001e-72"
     Typing          complement(710..885)
                     /name="rep_cluster_1017"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="92.697"
                     /coverage="94.0"
                     /evalue="1.04e-65"
     Typing          complement(1017..1999)
                     /name="rep_cluster_2100"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.593"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          2426..3168
                     /name="rep_cluster_1733"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 acgatgttcc ttatttatcc tcataaaaaa caatagctga aatatataac caattactgt
       61 gtgtttgaat ttctaataca tgaatatcat tctttaaaaa cctattaact tgtttatcta
      121 attgacgatg agtaaaagta gcgaaagttt taatcttcat gatatctctc cttttataaa
      181 aatagcaatc cttattacaa tattaaacac ttttattttg gattttaaga ggcattttga
      241 agacttagag gcaaatcata taggttttgt acttaaaaat ctatacagtc tcttaaaacg
      301 caaatatgag ccaaataaat atatgctaat ttcacaaaca aaaatttcag caaaatcagt
      361 gactaatttt ttagatactg cccatttaca tgcaaattta aaaattagca taaaatactt
      421 taaaacttcc ccatgttttt ctaaattcct gcagggcttt tcttatcaaa aacttagaaa
      481 ttttaattta actctaaaat ctccgtaaga gcataaggga aatttgctat cattcaaaaa
      541 tgatagatct ggcaaggcca gacattccaa gggttttaag ttattttaaa gtgatatcat
      601 acaaagctgt agtgtcacac ttttgtgaca ctacatacag catttgtcac aaaaataaga
      661 cagcactttt ttacagaaaa acaataaaaa aagacatcag ttatcactaa tgtcttaaat
      721 aataattttg cttttcgaaa ttccaaattg cggtaattga atgtgctttt tttcttcgtc
      781 tgtcgtttta tcttcatcac ttgtattaat caaattacca tcttcggcat cgtctaagtt
      841 taaaatttta tgcttttgtt taagcaatcc accataactt aacatacgtt ttcgatacaa
      901 acctttttct aaatcactta caatttcttg atttttttcg tcgtcatcag ttaaaaagtc
      961 agatgattta acggaatatt ttgatgtctc ttcgagtgtt ataaaatcat ttgaattatt
     1021 gattaaagat attatattgt ttcatgtttt tacggcgcat ataaagggca tgtgtttctt
     1081 caagttcagt tagaattgtt tgcattaaat aagcttgcat tgacttgatt gtttcctttt
     1141 ggcctttaac tcccctatca tgtatagctt ttttaagtct ttttaaagaa gttaatattt
     1201 catcctcaat gtcctctaac atgtaatgca tatcttcatg ccttgaatta aatgattttt
     1261 ttgctttaag aataacagcc tttatgattt ctaaatctct ataatcatat tttaataaat
     1321 aattagttag ttgttctggg aattcttgca atagcatttc tttatcatca aaattatgtg
     1381 taaattgatt tgaatgattt gaatgattac taatttcatt tttgtacttt atatcattca
     1441 agtcattcat atcattattc tcagtatcat taaagtcaat gtcattaaag tcagtatcat
     1501 tagtgttcga ttttcgaact tctggacgtt cgattttcga acttctggac gttcgatttt
     1561 cgaacttctg gacgttcgat tttcgaactt ccttctcgcc gtaaggttca acatcgtttt
     1621 cttctttttc tattttgtaa atatcacgtt ctgtgacaat aggtttcatt aaatatagaa
     1681 tatttggttt atttaaacca cgtcgttttt gaatgagtag accatcgttt tctaaccctt
     1741 tttttatttt tgttaacttt tcttttttac aatttaagat ttccattagc ttttcatttg
     1801 aataaacaaa gtaaatgtta ccatcttcat caacccagct atttttaata gataaattta
     1861 agcgatcacg taagatagca taggctattt tcatatcatt agttagattt ttataatttt
     1921 cactggtaaa gaatacttta gggatttgat aaaatctttc tttgtaattt tcttgcactg
     1981 taaaatattg attttgcatg acaaaaaacc tctttccata ttttagtttg gtaagaggta
     2041 ataaaacgtt tttatttagc tttacattta tttaatgatt taggtgcttg cactaagata
     2101 ttattcatta tataatacaa gtatcgaaaa ttatataaat aaacagtttc taaacgtttt
     2161 attaccaaac cccgactatt accagtagtt ggggtttttg ttatattaag tttattatag
     2221 cactttaaat aaacttataa aagggaaaat atagctttat caagggttta taaacccttg
     2281 ataaatatca taaacctttc ataaaccctt gataaaaagg ttgatggatg tttattttta
     2341 tttattaatc actttattat taagcattat aagcttataa tattttatca agggtttata
     2401 aacattttat aaagggttga tgatatgaaa agtgtgaaaa agttgagtga agaattaggg
     2461 gttagtaagc aaacgatttt taataatatt aagcgattga atatagagac aataaaacag
     2521 gaaaacactt cgtttattaa agaagatacc gatatagaaa aaatcattca aagagtaaat
     2581 gaaaataaaa agaaatatgg ttttgaaagt actactgaag acaaacaaaa aaaagggtcg
     2641 gataatatta attttgaatc gaaaagcgat gctcaaatag tagaaatcct taaaaatcag
     2701 attgatactt taaataatca aattgaaaaa caagaaagtc gtcatgaaac aacaattgaa
     2761 ttttacagaa aagagttgca agaaagatca aaattgcttg aaaatcagca agttctggca
     2821 ttagagagta ataaaaagat tcaaaaatta gaaaatcaat tagaaaaaga aaaacacctt
     2881 aattatccct ttgatacatc tactaacact agacaaaacg ttgatgcaca agaaaaaaca
     2941 tatactacta atcctgtaaa tattaacaga gatcaggaag aaactaaaga aacagagatt
     3001 caatataagg atatatctgg aagtcaaagc gacgaaagta cacaaggtga agaagcaaaa
     3061 aaagaagacg ttccagctaa tctaaatgac aatgatagtg atatagaaga aaagagtgaa
     3121 gaaacggaac ctaaaaaggg gttttggagt cgtttgtttg gtagctaaaa taattgatta
     3181 ggcactaaaa gttataaaat tttagtgtct tttatatagt gagaacttct ggtaatcatc
     3241 gattatgtaa actaaagtat ttcaaataat taactgtatt aatactctca tcatgattgc
     3301 gttataaacg ttcgttattg agacaaaatt taatagtact actacacaaa aagagagtgc
     3361 gaattcgcac tctctttttg tgataaatga atggttaaga aaataattca tccacagttg
     3421 tatcaaacaa tcttgccaac ttaaatgcta atgtcaatgt aggatcatat ttattgtttt
     3481 ctattgcatt aatagtttgc ctagacactt ttaattcttt acttaaagtt tcttgagaaa
     3541 ttcctttttg ttttctatat tctctaattc tatttttcat taatttaacc tttagatgta
     3601 tattttttat ttgtagtata gtaattaaac agcataagaa atagtgctac aattataaag
     3661 aaaatttctg gatattgaga aaaccaagat ccttcaatac ttggtgacaa acctgtaaat
     3721 ttaagcacta gtgtaaataa catacaatat acaatccaaa taaaactttt agccagtatt
     3781 tcaataaaca ttttacgttg tctttcatcg tatcgatctt gttgtccttt tttatctaat
     3841 gtttctgaag gtaaatattt gttagttata gccgtccata aacaagaaaa aattaaaata
     3901 ataataaaag gaattaaatt cattataaca cctcataaat gtaaaaagta tttgacattt
     3961 atgagtgtaa atatttttga tacaaatgtc aaatactttt tacattataa tatattttaa
     4021 aacaccttat tagtaaaaca attactatat agaaagctgc gaactcgtac tcttttttct
     4081 tgtataatta ttaaaatctc aattcaataa tatgttatgg aatttgagac actgtgagag
     4141 acgctcattt gcattgacaa tcaatttatc aagataatcc cttatcatgt ttaattctat
     4201 aaactgtttg tcttgtgata ttaacttctt tcgcaatctt actaatcgct ttgccttctt
     4261 ctaacatttc caccacgcga tgataaataa cacgtttctg tgggtcttta gcatttggtg
     4321 aataaagtaa agggcgccct ttatatacgc ctttttcctt cgcaacttga atcccttgcg
     4381 cttgtcgacg tttactttca tttctctctt gttctgaaac cattgctaat atttgaatga
     4441 ttaaatcttt cataaactta tccagtaatg gattgccaat tacttcattc atcataggta
     4501 agctggtaat cattaactga acgtcttttt cttttaaata attcacagtt tcaataattt
     4561 catcatagtt acgtcctaaa cgatcaatag attccacaac gaatcgatct cccattctga
     4621 caaaattgag tgcttcttga aatacaggtc tattttccac tgactttccc gactgtttct
     4681 ctgtaaagat tttctccaca ccaaacgtct ttaaattatc caattgtctt tctaaatttt
     4741 gatctatcga tgatactctc gcataaccta taatcattca tcttcactcc ataataaata
     4801 tacaccctaa tcatacgttt taattgttat aatttcaaca attctttttg tatggttagg
     4861 gtgtactcaa agtgtacata tctataatta aaacttacta aaaataaata tagatttttt
     4921 ctttgtaaca gaaccgttca tttgaaggtc atctctatca taaatattta aattaactaa
     4981 aaattttaat catctgttta atacttatga aatgtattta cggtaggtat taaaattgat
     5041 gaaatttata taagtgcttt caatgaaaat gaccgtttat ttatcctcct gatttaagga
     5101 gttagaaatt tcgaaaacga ttctttccat ttgttgcatt tgttccatgt ccagatattt
     5161 aatacattat agaaaaccaa agaccatcac taattaaacg cagttttaaa atttcatcag
     5221 gattgccttc gtctttaaaa tgggcctctt ttaatataag ttctactctt tcatacctaa
     5281 ctctttcaat gccatcgttt catacgccga ttctcctgat tccatagcaa actcagcgat
     5341 aaacattggg aatactgcat tgagttctat tatatgctct ttcattcgtg gccatatttc
     5401 acctccagct ttaccgtatg ctgttataag ttgctctaat ccttcgtcgt cgaatacacg
     5461 atggtgtcct ataaagtcca ttgatgggtc ggagtgggtt gcttcagtcc agtctatgag
     5521 acctgtgacg tttgcttggt tatctaccat tatatgtcct ggatgtaagt ccccatgtat
     5581 catggtcgca tgtcgaggcc atagttcgtc gttttctaac cattgtttcc atctgttcca
     5641 taattcatct gatacgccat aagtttcttt aactttattc attcttcttt gaaagtcatt
     5701 ttttatttct tgtatggttt tgatatttat atgctgaacg ttaatgtttt cttctggtat
     5761 gttgtgtaaa tctacgagtg tttcagctaa tgtgttaata aagttttctg gtaatggttt
     5821 gtgttcaatt tcccatacat aattttgtat ttctggatct attgtggctg cgggtttacc
     5881 tgtaagtttt gggtaagcaa taaggtcttt tgcatgtact ttccacttcg gtatttcaaa
     5941 tgaaacattc ttctgtaaga agtctaccgt ttgtttttcg ggttttgttc gtttataaac
     6001 gtcaggtctt cttggtagtc tcaaaaccca ttctactcca tgtttatctt ttccaaatgc
     6061 aacttgaaaa tcaagtcccg attcattcaa tgagattgtt tgaggttgga tgtgtaattg
     6121 atatttttct gcacatttaa taatttcatt atgtcgagtc attttattgg atccttattt
     6181 ctattatatt tttcttgtga acgtattttt tatattgata taaatgaacc taatattcaa
     6241 tataaattag tgtatagttt ttaagttata tcatgaagag attgtcctgt taattcccat
     6301 tttttatctg atacatgttt aacaaacctt gtatcatgtg atgtaaacaa aatgattcca
     6361 ggatatttat tcataaacat ttctaatgct tctaatgttt taatatctaa aaaattagtt
     6421 ggttcatcca aaattaacat attcgctttc gttgaaaata atactgctaa cgataatttc
     6481 gttctttccc caccactcaa aacattacaa gaacgatcaa gtgcttcatt taaacccaag
     6541 ttatttaaaa tagctctact gaatgattct gatgaatccg tttcatccat taaatattgc
     6601 aataatgaaa cgtcacgcat gtcttcataa gcaagttgac gatagtatgc catttgcact
     6661 ttaggagaac aatcaattcc ctctatttgg tggtaaatag cttcaagtaa agttgtctta
     6721 cctacaccat ttgcacctac gagcgctata tttttgccat atggtatttg gaatcgtact
     6781 tgtgttagca gtttttgact tcctttaacc aatgttagat tttgtgcaat gattggataa
     6841 ttattatgga tatcataaat tttattttgt gggaaattga attcatgata actttgtggt
     6901 ttttcaactt cttccaaatg ttccattctt ttttcaatat gcttagcttg tttttgagca
     6961 gccttctcaa ccgtgccttt ttgttttgat gcacttaaac gatctggtgc tatacttttg
     7021 tttttttgtt ttgatgatgc ttgtgccatt tgttgcgctt gatttcgttt agctttactg
     7081 gcttgggaca atctttgttt ttcacttata tactgttcat attgacgttg ttgttctaac
     7141 tgttcttgtt catattgatt ttgatactgt gtgtaattac ctttaaacac tcttattgtg
     7201 ccatcttctt gtatatccca aattgtgtca gcaatttggt ctataagtgc tctatcatga
     7261 cttactataa ttaaagtacc atagtaatat tttaaaatat ttttcagata atctttacca
     7321 attttatcca agtgatttgt aggttcatct aaaagtaata tcggactata atttgatatg
     7381 acattagcta atttatattt tgctttttca ccaccactca tactgtcggt tgtatgcata
     7441 ggtatatgga gttcactcat taaactaccg tctaacgtgt taaaatcatt ttccacatcc
     7501 atgttaagct gttcaaaata ttgaatttcg ccaaccgttt caactgttcc agattctggt
     7561 tttgtttttt gagcaatcat atttagtaat gtggttttgc cagtaccatt acccccaata
     7621 agtgctattt tttcaaattg gtaagcgtaa agatgaccga tgttaagtga tcgtaaatct
     7681 gtcaatttat gattgatttg gttaaattta attgtatatt gttccatatt tatacactcc
     7741 ttgtatattt aaaggacgtg tacgcaaaaa aatgagacag gctactcccg tctcattcac
     7801 attacacttt caaacactta aaaatttatt atgatgtttt agtatttgaa agcgtttatt
     7861 attcctatcg aaggataaaa aatgacataa gtcatcctat gagtgtgtat tgcggacaag
     7921 cctttttgaa ttaatttagt tttgtattca aaaaggttta tttgagtctc atagaagctg
     7981 tcattttaat cctccttcat cgataaaata gtaatgttaa tataacattt tgttggtttt
     8041 tttacaatat atctctaagt agaaagatta tataacaaaa gtataaaaat acaattttag
     8101 attgattata catctcctta atttagagtg tactcataaa atacggttct gttgcaaagt
     8161 tgaatttata atataatttt aacaaaaagg agtcttctgt atgaactatt tcagatataa
     8221 acaatttaac aaggatgtta tcactgtagc cgttggctac tatctaagat atgcattgag
     8281 ctatcgtgat atatctgaaa tattaagaga acgtggtgta aacgttcatc attcaacgat
     8341 ctaccgttgg gttcaagaat atgccccaat tttatatcaa atttggaaga aaaagcataa
     8401 aaaagcttat tacaaatggc gtattgatga gacgtatatc aaaataaaag gaaaatggag
     8461 ctatttatat cgtgccattg atacagaggg acatacatta gatatttggt tgcgtaagca
     8521 acgagataat cattcagcat atgcgtttat caaacgtctc attaaacaat ttggtaagcc
     8581 tcaaaaggta gttacagatc aggcaccttc aacgaaggca gcaatggcta aaataattaa
     8641 agcttttaaa cttaaacctg actgtcattg tacatcgaaa tatctgaata acctcattga
     8701 gcaagatcac cgtcatatta aagtaagaaa gacaagatat caaagtatca atacggcaaa
     8761 gaatacttta aaaggtattg aatgtattta cgctctatat aaaaagaacc gtaggtctct
     8821 tcagatctac ggattttccc catgccacga aattagcatc atgctagcaa gttaaacgaa
     8881 cactgacatg atatattagt gattagctat attttttact ttgcaacaga accaaataaa
     8941 atattatatt ttactggatg aattgtttta gtacctagat ttagatgtct aaaaagcttt
     9001 aactacaagc tttttagaca tctaatcttt tctgaagtac atccgcaact gtccatactc
     9061 tgatgtttta tatcttttct aaaagttcgc tagatagagt tctatattag agatgtaaag
     9121 agttttggtg aagaggtttg tgagtatggc ttttataacc agggtgcaat gagaagcact
     9181 aacagcagct agcttaagaa cgcataggat atacttttta tggaagtcac agaggaggaa
     9241 taaaatttga acaggattaa cagagtaacc tctattctta ttcagctgca atcaaaaaaa
     9301 taattcctgc caaagaaatt gcacagcgat ttaatataag cttaaggaca gtttacagag
     9361 atatccggac acttgaagaa gccggaatac caattggatc tgaggccgga aaaggatatt
     9421 ttcttgtaga gggcttccta cttctgccgg taatgtttac agcggcggaa gtgggtgcat
     9481 tgattacagc agggaaattt ttaaattgcc atggagatga atcatttata aaggattttg
     9541 attcagctat gtataaaatc aaatctattt tgaagcatgg tgaaaaaaac tatgcacagg
     9601 agttggagaa cagtattaac gtgtacagca catctggaca gaaaaataca ttggcggata
     9661 acgttattgc agcaattcag actgcaatct gcaataaaag ggtaatatca attcaatatc
     9721 ctgcatcagg agggcaagaa ccggaaagca gaatgataga gcctatatca ctggggtttt
     9781 atgaacagaa ctggtactta atcggttttg caggctaaga aatgaatata ggaattttcg
     9841 tgtggatcgg attaaaagca tttgcataga agaagagctc tgtcaaagcc atgatggctc
     9901 tttggaacaa atattaaaac aaatgctggt tctgttgcaa agtaaaaaaa tatagctaac
     9961 cactaattta tcatgtcagt gttcgcttaa cttgctagca tgatgctaat ttcgtggcat
    10021 ggcgaaaatc cgtagatctg aagagacctg cggttctttt tatatagagc gtaaatacac
    10081 tcaatacctt ttaaagtatt ctttgctgta ttgatacttt gataccttgt ctttcttact
    10141 ttaatatgac ggtgatcttg ctcaatgagg ttattcagat atttcgatgt acaatggcag
    10201 tcaggtttaa gtttaaaagc tttaattact ttaaccattg ctaccttcgt tgaaggtgcc
    10261 tgatctgtaa ttaccttttg aggtttacca aattgtttaa tgagacgttt gataaacgca
    10321 tatgctgaat gattatctcg ttgcttacgc aaccaaatat ctaatgtatg tccctctgca
    10381 tcaatggcac gatataaata gctccatttt ccttttattt tgatgtacgt ctcatcaata
    10441 cgccatttgt aataagcttt tttatgcttt ttcttccaaa tttgatataa aattggggca
    10501 tattcttgaa cccaacggta gaccgttgaa tgatgaacgt ttacaccacg ttcccttaat
    10561 atttcagata tatcacgata actcaatgca tatcttagat agtagccaac agctacagtg
    10621 ataacatcct tgttaaattg tttatatctg aaatagttca tacagaagac tcctttttgt
    10681 taaaattata ctataaattc aactttgcaa cagaacctca tttactatat gggcatctct
    10741 ttcattatta atacaaagct ttgtatctcc gatattaggc aaaggtgtaa acgaattagg
    10801 tgatactata ggattcaaca ttatattaat cgtttcttta ataatgatta tcttcttatt
    10861 ttttataaat cgtagtaaaa atatctccta tgattatata aaagttcaaa gaggtgaagc
    10921 caatgaataa attagaaaaa tggtctttgg tatttattat ttttacattt ctctcttcat
    10981 tagcactttt atatttcaaa tataatttta gttcggttat gccagtccta agtctttcta
    11041 ttttaactat actaatattg ttgacgagta ttattactgt agtttcagtt aatgatgaag
    11101 atacttaaaa cgttcattag tgaaacaggt attatattaa aaaagcgtac gaatttgtac
    11161 gcttttttct tgtgttatta ttaaaatctc ataacaggaa aatattatga gattttagac
    11221 gctgtcagaa cgtctctttt acatcgagtg acattgaatc aaagtctttg tatgttaatg
    11281 atatataaaa ttatttagta gattcattat agtaagctag attagttgct ctacttgttt
    11341 ttattctctt ttgcctctaa tttattgaga taacgataaa tagttgtacg tgaaacttgc
    11401 cactgctctg caattgtttt aattggcgta ccattatcat aaagtgtctt aagtaagttt
    11461 aaatcttgtt tatttaattt ttcaggtcta cctccatatc ggcctctagc acgtgctgca
    11521 attcgaccgg ctgatgatcg ctctaaaatt aaattacgtt caaactctgc aaatgctgcg
    11581 aataaatgaa ataataattg tcctgtagaa cttgatttat ccatcgttat attttcttct
    11641 aaactatgaa aactcacacc tcgttcgtta agttcattaa ctaacgtgat taaatcctcc
    11701 atgttccgtc ctagtctatc taatctccaa acaacaatcg tatctcctga cctcgcaaat
    11761 tcaattgctt tatctaaacc aggtcgctta ctttttgaac cactcatatg gtcattaaat
    11821 atcttttcac aaccatatgt atttaatcga tcctcctgta aattcaaatt ttgtaatcca
    11881 gttgaaactc ttgcataacc tattttcaaa atacagacct cctatataca cctttagtgt
    11941 accataactt gattacgagg tcttttgtga acatagattt tttgttgggt ttttgaacac
    12001 ataattctat gtaatactta cttatttaga caaaaaacaa gagtgtacag aaaatggtta
    12061 ttttctggac actctcatct ttaataatat attttaaatg tcattaacaa aactaattta
    12121 ataagagtca agtatggttt acatatgtat tatgtttgaa acatacctct aattactttt
    12181 tactaatatc atttaaaatg tctcgcaatt cttcaatttc tttgttattt aattcttcat
    12241 ttttcgcaaa attcagcact aaacttttca tatcccctcc atacagttta ttaagaaagg
    12301 ttttagcagt tttcatttta atatcgtctt ctttaatatt tgatgagtaa aaataaatat
    12361 tttctgattt gtatcgtttt ataatctctt ttttatatag tcttgtgatt aatgttctaa
    12421 tcgttttatc actaacttct ttatattttt gaatttcaac tacaatttca ttagctgata
    12481 ctgatttttt atcccatatt atattcataa catcccattc agccatagat atttcaactt
    12541 gcttattggt catttaaaac acccattcct tttaatattt tttcacttat taattcagca
    12601 tttttcccag acgggtttcc atctgataaa tgtgtagcaa aataatactt atcatgattt
    12661 gtaattacgt aacctacaaa ccacccatta ttatacttcc cgtttactat acctgtacct
    12721 gttttcccat acagttcata cttttcattt ttcttaatca ataatgaaga agataattga
    12781 ttctttgctt ttttactaaa atggttattt tgttccatca tatttttaaa aactattact
    12841 tgttcaagat tagatatttt caaactatct tccatccaat agcttttata acttcccaaa
    12901 ttttcattac cataatttaa ttgcttgagt tgagccgcag tatagttctt tggtatttga
    12961 ttactaatac gttcgaagta ccaattaact gaattttgca ttgctgtatt taaatcttgt
    13021 tccttattcc aagactcgaa aagataatgt ttatgattcc atgacatacg tgaattttta
    13081 tcacttataa tatgacggtc aagtccaaac agtgctaaat aaattttgta agttgaatca
    13141 ggagaatatc tttttctact ttctttttca ttataaatat agtatttgtc tttcttcatg
    13201 ctgtacataa cgaaagatcc actatttgaa ccaaaatttt tactttcatc taaaatttgg
    13261 taatcgcttt gtaagggctt tttataatta taatcagtta aggattgccc cattaaaaac
    13321 tggctttgaa ttatcatgat aaaaaaagta aaaatacaaa taaaaattag aattaatttt
    13381 gactgctttt tcagatcggc ttcttttata ttaattaatc tacttttgag taatgatttt
    13441 ttaccattaa atgaatggct taatatattt ttgttggaaa atggggtttt taatacggag
    13501 tccataatag attccgcata agttttaaat tcatttttgt taatattatt aaggacaaat
    13561 ctatcggctt ctacttcatt gtcatgaatt atctttcttt ttacaatatg tactaatgga
    13621 ttgtaactca taataataga gaagatatta aagataatta aatgtaaagt atctctattt
    13681 ttagcatgag catattcatg cagtattata tattttagtc ttttgtcaat tacactttta
    13741 aaatatgaac taggaatcaa aataatatat ttcccatacc aaaaagttat tggagattga
    13801 atagcctctg cttttcgaat cacaatattt tttttatatt gatggttgaa aagtatcgta
    13861 tctattttat ttttttcatt ttcgtttaga taaagtgact gtttctttaa atatttaaga
    13921 tataataagg ctttcaaaaa tttaaaactt aaaataataa ctaaaactat ccaaataact
    13981 gtgcagatat tatcaattga atcccaatta aacttatgga tatctgttgt gaactcttga
    14041 ataggtttgg tggtatttat gttatggttc aaatcgtgtg acttactttc aactgtgggc
    14101 gcttgattat tcacattatt aaattttata aaagagaatt taattgggat aaaaggaatt
    14161 aatccagcaa gcatagttag ataccaaact ttataattta aactataatt aaaatagcgt
    14221 tttaatatgt acctaaaaaa tactaacaat agaaatataa aacaaaagct tactacgctc
    14281 attattagta atttagccat tttgacacct tctttcaaat atttataata aacaattgac
    14341 atcaatatta caattgtaat attattgatt tataaaaatt acaactgtaa tatcggaggg
    14401 tttattttga aaaagttaat atttttaatt gtaattgctt tagttttaag tgcatgtaat
    14461 tcaaacagtt cacatgccaa agagttaaat gatttagaaa aaaaatataa tgctcatatt
    14521 ggtgtttatg ctttaaatac taaaagtggt aaggaagtaa aatttaattc agataagaga
    14581 tttgcctatg cttcgacttc aaaagcgata aatagtgcta ttttgttaga acaagtacct
    14641 tataataagt taaataaaaa agtacatatt aacaaagatg atatagttgc ttattctcct
    14701 attttagaaa aatatgtagg aaaagatatc actttaaaag aacttattga ggcttcaatg
    14761 acatatagtg ataatacagc aaacaataaa attataaaag aaatcggtgg aatcaaaaaa
    14821 gttaaacaac gtctaaaaga actaggagat aaagtaacaa atccagttag atatgagata
    14881 gaattaaatt actattcacc aaagagcaaa aaagatactt caacgcctgc tgctttcggc
    14941 aagactttaa ataaacttat cgcaaatgga aaattaagca aaaaaaataa aaatttctta
    15001 cttgatttaa tgtttaataa taaaaacgga gacactttaa ttaaagatgg tgttccaaaa
    15061 gactataagg ttgctgataa aagtggtcaa gcaataacat atgcttctag aaatgatgtt
    15121 gcttttgttt atcctaaggg ccaatctgaa cctattgttt tagtcatttt tacgaataaa
    15181 gacaataaaa gtgataagcc aaatgataag ttgataagtg aaaccgccaa gagtgtaatg
    15241 aaggaatttt aatattctaa atgcataata aatactgata acatcttata gtttgtatta
    15301 tattttgtat tatcgttgac atgtataatt ttgatatcaa aaactgattt tccctttatt
    15361 attttcgaga tttattttct taattctctt taacaaacta gaaatattgt atatacaaaa
    15421 aatcataaat aatagatgaa tagtttaatt ataggtgttc atcaatcgaa aaagcaacgt
    15481 atcttattta aagtgcgttg cttttttctc atttataagg ttaaataatt ctcatatatc
    15541 aagcaaagtg acaatagcat tttacaagta ttttttattg ttcgattagg gtaaacctaa
    15601 ataatacata aattatatta caatatgttt attatagagg ctaaagtatc ttagaaattt
    15661 ggatagtagg tttttcggga ataaaagtat agttggcttt aatatataat taagctaagc
    15721 tatcatttat atttactcga ttataattcg cacttcaact tttttataac gtaaaaatta
    15781 aaacgtagtt ttatttatct ttagtaatat ctttttaaac actacagttt cttcattagt
    15841 taaattagcg aagtaatgat tattaagttg ataggctttc ttttctaatg ttggccataa
    15901 gtcttttgct ttatttgtac tgtttattag cacagttctt ctattttcat tatcagtttg
    15961 acgtgttatt agatcctttt tggacatctt atctaatatt ccagatattg ttgaaggttc
    16021 taaatttaaa gtattaccaa tcgctttagg tgtattcaaa ttactattaa tcaagcaatt
    16081 caaaacacca tattctgctg gagtaatatt atagggactt aataaacttt taaaatgttt
    16141 aaaaactcta ttctgagaag tactcaacaa ataatttata caattatcta attccacaac
    16201 taaaacctct cttaaatcat tagtattgac tcgcttatca tatcatgata agttttgtag
    16261 gaaaatagtt ttgcaacaaa aacatacttc tacaaaacaa ttgtgaaaga aggctaataa
    16321 atgttcaatg cggtagtagt gagaaaaagt gcatcaaatg ttagttataa agtagaaaaa
    16381 gttgatgaat ctcatttatc gaagggtgat gtattagtaa aagtggtata ctcttcaata
    16441 aattataagg atatgctagc tttacaatat aaaggcggtg taattagaga ttatcctatg
    16501 attcctggta tagattttgc aggtattgtt gaatcaagtt cgaatgataa gtttaaagaa
    16561 ggcgataatg tattagttac tggttatgat gttggcgtga cacatacagg tggattttca
    16621 gaatatgcac aagtgcctgg agagtggatt gttcctattc cccaagaaat gtctattaaa
    16681 gagtctatgg tatatggcac agccggtttt acggcagcat tatcaatttt tgaactagaa
    16741 aaatatggaa tgaatatcaa atcacaacct gaaattttag tgtctggggc tacaggtggt
    16801 gtgggcagtg ttgctataca aattttacat aaaattggat atgaaaatat cactgctatc
    16861 gtaagaaaag aaaagcaaat agaaatcgca aaaaaattag gtgcaaaaca agtaataata
    16921 attgaagatg ataataaacc gcttaaaaaa ggtatttttg attatttctt agatacagtg
    16981 gggagtaatg taacattata cggtttaaaa cgtctaaatt atcaaggtgt tgctactgta
    17041 tgtggaaatg tagcaggaaa ttcacttaac gctaatatat taccgtttat tcttagaggt
    17101 attaaattaa ttggcattga ttctgtatat gttgatcata atatccgtga agatatatgg
    17161 agtaagttag caaatgaatg gaatatagga aattcacttc tatacaatga aattggattt
    17221 gaagaattct ataaaacgat agatcagctt ttaaaaggac aacatttagg aagaactatt
    17281 ttaaaagtat aagtgtgagt attcattaat acatttacta ttaattcaat cattttgcat
    17341 ttctctacta accagtgtta taatttatat aacgaaaatg attaacaatt aatgcaccaa
    17401 tccccacact attgcagtag tgtggggatt ttttcgatgc tggcttataa agtcgcctat
    17461 taattatttg ttgcgtttac taagccaata agtataatac gcaacagcac agccactgat
    17521 gactggtgct atgatgtgaa cgaaaatgat tagcaaagta atgcacctcc tctcttcgtc
    17581 aattgacgcc tgagagatag gcgactctat tattatacca tctgtgaata tacaagcata
    17641 tctacttccg ataagtcgtc ttatgttata taactttgtt ttttatagta tcaagacaag
    17701 aagaaactcg tttcaaaaac cctcatgatt tttagagaaa aactctctta tttcatcgtc
    17761 tttaataaaa taatatgcca tctttccatc tttataaaaa tcaagtacct catttttata
    17821 taaaagcctt aaatgatgtg aagttgaagc aacactcatt ttcaatatca aagaaatatc
    17881 acaaacacac aactcatctt ctttaatcaa agataatatg attttcaatt tcttctcatc
    17941 acaaattttt tctaaaatgt taagtaattt cttagattta tcatcttcta aaaaacttaa
    18001 agcattgtta actttatcct catgtacaca gatcacatca caagtatttt cataactcat
    18061 ataaaatcac accctaaatt aaaatataaa tcctaaaatt gtttgaatag tgtcattttc
    18121 aataataata aataaaccta aagctatata aataatagcc ataatccaac gactaaattt
    18181 ctcaacaatt tctccaattc ctggaatatt agctaatttt tgtgcagtaa acaccaagaa
    18241 gaaaattaaa attaaaaaga caaacagagt aagtaataaa ttagtaacac ttaatgtcac
    18301 aaaatacgga acaaataaac caatattatc ggcgccacaa cttgctatcg taacaattgc
    18361 aaccgtacca actaatttag acaatccttt ttcattcaat tcttttttag ctctcttttc
    18421 tccttcacaa tcatcataaa tagccacttt aattccaaga taaattggta ttaaacccaa
    18481 taaacctaat atccactttt ctggaacata atttaataca aaagctaaaa acaaactaac
    18541 taatattaaa ataatagacc ctaaatattg accaacataa atatctctat attcttttct
    18601 agtctttgct ctagcaaaaa atattaataa aattactaat aaatcaactg ctgtagcaat
    18661 ataaagaaca gcagcagcaa caaccgtttg aatcataata cacctcattc aaaaatattt
    18721 ttgaatgtat tataacttat atttttaaat aatcataggt gctttattcc aattgcttta
    18781 ttgacgttga gcctcggaac ccttaacaat cccaaaactt gtcgaatggt cggcttaata
    18841 gctcacgcta tgccgacatt cgtctgcaag tttagttaag ggttcttctc aacatcaata
    18901 aattttttcg gcataaatgc gtgtctatgc gtagacatgg agacacttca gaattatgga
    18961 gtgattacat gagtttaact atttttcttt attcagtttt aggaagttta ttagcaaatt
    19021 atatctacga aaaatcttca aaataaataa ctttttcggt tctactttgt acactttatc
    19081 tacctggtag acctaattgt tattgcttta caggtctaaa attcgtcgtt ataatctagt
    19141 taaatcccgt aagggcgcac ttatacgtcg gataaatcga catgtgcaaa aacgtaatcg
    19201 accttcgtcg atttttttat ttcaaaatta aagaaacggc ttgagatatt ccgagcagtt
    19261 ataaaaatta atttgcgttg aatattgcta ctacattctt gaaaaagtga tgtagattta
    19321 tagcccataa cttttttgaa ttacatcgac gatacggcgt cgaaagaaaa ataaatagac
    19381 cgtatgaaag aaaaagctac ctcactttat ctggggtagc ttttattttt tatgccctta
    19441 ttttgaattt taagagggca ttttaaagat ttaggggtga ttcatatagt tttatatcta
    19501 aaacttatat atgcttttaa aacgcaaata tgagccaaat aaatatatgc tattttcaaa
    19561 aacaaaaatt tgagcaaaaa caataactat ttttagacac tgcccattta catgcaaatt
    19621 aaaaattagc ataaaattct ttaaaacttc cccacgtttt tctaaattcc tgtagggcgt
    19681 ttttatcaaa aatcaagaca agaagaaact cgttcacact cgtttcaaaa aaaacaagaa
    19741 atctaatcta tacacctacc gttttccaac cccctcaaag catacaaatt aaaaacaaaa
    19801 ttattcataa tcttactttc ttttaacaaa aacataaaaa ccataaatag acaaattaac
    19861 tatcaaaggc aataaacagt ataaaaaaac cacgaataaa tcttcatcaa catctaaaat
    19921 aaaaaagaat aaaacaatta acaaaatact aattaacaaa cctaaaagtg gcaaactttt
    19981 tatatatttt tctaaatttt cattcataaa atagactcct ttcaaaaata tgtttataaa
    20041 tatattaaaa taaatattga ttttataaag cgcttactta tacaattaaa atatcttatt
    20101 atcttggagg tatcaaatga aaattataaa attattttca ataatttcct tgttcctact
    20161 ggtatttagc gcgaattttt ctaatgctta cgcaaatgaa gaacaaaaaa gttctttact
    20221 agaaaatcaa aaagaaaaat tgaaaagcaa aaacatcgaa gtatcacaaa tgaccaagaa
    20281 agaaataagt tttctagaac aattgcaaaa taaaaatgaa gatatgcaaa aattcgaaaa
    20341 gcaaatgaaa aaagaaggat ttaaaaaaat aaagctagaa gacaaaaatt ctaaattaaa
    20401 atatctagct acagaagcaa atgataaaaa tgcatatggc tacatagcta ataacgctta
    20461 taaaaatgaa aaaacaaaag aaattgtagt ttctgaaaca atatatgata actacaacaa
    20521 aaaaatcaca aaattcattg ccgaaaaaag aagtatgact gaaaacaaag agggaaaaat
    20581 acttattaac aaaaattacg ttgaatataa ggctgaaaaa gttgataaaa acagaccggt
    20641 aacatatgca ggattcaaat ggaacggcaa agcattcgct tgtagtatgg ctggacttta
    20701 tgcatgtgct cactactgtg gagtatgggc aatcgtaaat ccaatagccg gcggtgtatg
    20761 tgaagcagtt tgcggaactg catttgcagc tggatgctct gtaggttgat tttattccaa
    20821 ttgttttatt gacgttgagc ctcggaaccc ttaacaatcc caaaacttgt cgaatggtcg
    20881 gcttaatagc tcacgctatg ccgacattcg tctgcaagtt tagttaaggg ttcttctcaa
    20941 catcaataaa ttttttcggc ataaat
//
