LOCUS       NZ_CP125171             9293 bp    DNA     circular CON 05-APR-2024
DEFINITION  Klebsiella pneumoniae strain 161 plasmid unnamed5, complete
            sequence.
ACCESSION   NZ_CP125171
VERSION     NZ_CP125171.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN33790395
            Assembly: GCF_037477785.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 9293)
  AUTHORS   Konanov,D.N.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-MAR-2023) Laboratory of Mathematical Biology and
            Bioinformatics, Research Institute for Systems Biology and Medicine,
            Nauchniy Proezd, Moscow 117246, Russia
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. 0.4.8
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 103x
            Sequencing Technology             :: Illumina; Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_037477785.1-RS_2024_04_05
            Annotation Date                   :: 04/05/2024 19:33:28
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,463
            CDSs (total)                      :: 5,343
            Genes (coding)                    :: 5,169
            CDSs (with protein)               :: 5,169
            Genes (RNA)                       :: 120
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 83
            ncRNAs                            :: 12
            Pseudo Genes (total)              :: 174
            CDSs (without protein)            :: 174
            Pseudo Genes (ambiguous residues) :: 0 of 174
            Pseudo Genes (frameshifted)       :: 73 of 174
            Pseudo Genes (incomplete)         :: 104 of 174
            Pseudo Genes (internal stop)      :: 32 of 174
            Pseudo Genes (multiple problems)  :: 33 of 174
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP125171.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..9293
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="161"
                     /db_xref="taxon:573"
                     /plasmid="unnamed5"
                     /geo_loc_name="Russia"
                     /collection_date="2022"
     gene            complement(join(7766..9293,1..158))
                     /locus_tag="P4G16_RS27165"
                     /old_locus_tag="P4G16_27160"
     CDS             complement(join(7766..9293,1..158))
                     /locus_tag="P4G16_RS27165"
                     /old_locus_tag="P4G16_27160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin-like bacteriocin tRNase domain-containing
                     protein"
                     /protein_id="WP_004178188.1"
                     /translation="MSGGDGRGPGNSGLGHNGGQASGNVNGTSGKGGPSSGGGTDPNSG
                     PGWGTTHTPNGDIHNYNPGEFGNGGSKPGGNGGNSGNHSGSSGGGQSSATAMAFGLPAL
                     ATPGAEGLALSVSGDALSAAVADVLAALKGPFKFGLWGIAIYGVLPSEIAKDDPKMMSK
                     IVTSLPADTVTETPVSSLPLDQATVSVTKRVADIVKDERQHIAVVTGRPMSVPVVDAKP
                     TKRPGVFSVSIPGLPSLQVSVPKGVPAAKAPPKGIIAEKGDSRPAGFTAGGNSREAVIR
                     FPKESGQKPVYVSVTDVLTPAQVKQRLEEEKRRQQAWDAAHPEEGLKREYDKAKAELDA
                     EDKNIATLNSRIASTEKAIPGARAAVQEADKKVKEAEANKDDFVTYNPPHEYGSGWQDQ
                     VRYLDKDIQNQNEKLKAAQTSLNEMNESLSRDKAALSGAMESRKQKEKKAKDAENKLNE
                     EKKKPRKGTKDYGHDYFPDPKTEDIKGLGELKEGKPKTPKQGGGGKRARWYGDKKRKIY
                     EWDSQHGELEGYRASDGEHLGAFDPKTGKQVKGPDPKRNIKKYL"
                     /name="colicin-like bacteriocin tRNase domain-containing
                     protein"
     gene            560..979
                     /locus_tag="P4G16_RS27170"
                     /old_locus_tag="P4G16_27165"
     CDS             560..979
                     /locus_tag="P4G16_RS27170"
                     /old_locus_tag="P4G16_27165"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016247941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Exc2 family lipoprotein"
                     /protein_id="WP_001254601.1"
                     /translation="MRRSGSKLCLIAMITATATLTACAPKGSVEQHTRHYVYASDDGFD
                     PNFSTQKADTTRMMVPFFRQFWDMGAKDKATGKSRSDVQQRIQQFHSQEFLNSLQGTTQ
                     FAGTDYRSKDLTPKKSRLLADTISAVYLDGYEGRQ"
                     /name="Exc2 family lipoprotein"
     gene            1285..1548
                     /locus_tag="P4G16_RS27175"
                     /old_locus_tag="P4G16_27170"
     CDS             1285..1548
                     /locus_tag="P4G16_RS27175"
                     /old_locus_tag="P4G16_27170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000072676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000072676.1"
                     /translation="MSNTTHYENANFLRELAESLPRILPEGGPDKAALLQRLANEELAQ
                     AEYEDQVRAKVTAARADTRPGMTTEQLRQRLHGRYQELRDAV"
                     /name="hypothetical protein"
     gene            1538..1837
                     /locus_tag="P4G16_RS27180"
                     /old_locus_tag="P4G16_27175"
     CDS             1538..1837
                     /locus_tag="P4G16_RS27180"
                     /old_locus_tag="P4G16_27175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001146176.1"
                     /GO_function="GO:0008657 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) inhibitor activity
                     [Evidence IEA]; GO:0042803 - protein homodimerization
                     activity [Evidence IEA]"
                     /GO_process="GO:0030541 - plasmid partitioning [Evidence
                     IEA]; GO:0051290 - protein heterotetramerization [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_001146176.1"
                     /translation="MPYDVEWKQGAIEDVTTLFDYIAENSSLWDAQNVTDRVLAAADKL
                     ADFPRLYEVDSRYGEDVRRISLMGQHVLYDVDDQTRKVRVLAVVGQRQNPHIVL"
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            complement(1899..2276)
                     /locus_tag="P4G16_RS27185"
                     /old_locus_tag="P4G16_27180"
     CDS             complement(1899..2276)
                     /locus_tag="P4G16_RS27185"
                     /old_locus_tag="P4G16_27180"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000312627.1"
                     /translation="MAWVTVRQATELTGKARSSLYRDMAKGRVSYRTEADGGRVVDTSE
                     LIRVYGELRQDETHERDELRLSGETEKMASDALIAEIKALREEVAGLRQEMQSMRLLEH
                     KPETAETPAGTPRRWWPWGKR"
                     /name="hypothetical protein"
     gene            2345..2524
                     /locus_tag="P4G16_RS27190"
                     /old_locus_tag="P4G16_27185"
     CDS             2345..2524
                     /locus_tag="P4G16_RS27190"
                     /old_locus_tag="P4G16_27185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rop family plasmid primer RNA-binding protein"
                     /protein_id="WP_000165971.1"
                     /translation="MTKQEKTALNMAKFIKEQSLLLLDKLNELDMDTPADMCERLHEDA
                     ETLWQVMRDKLGEE"
                     /name="Rop family plasmid primer RNA-binding protein"
     gene            complement(2552..3082)
                     /locus_tag="P4G16_RS27195"
                     /old_locus_tag="P4G16_27190"
     CDS             complement(2552..3082)
                     /locus_tag="P4G16_RS27195"
                     /old_locus_tag="P4G16_27190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_004153058.1"
                     /translation="MALYMVFIEDAEDRNGERCIMPTSEHLEDMVVLAWQTGAYVFCFV
                     DRAQHLAMMKSIGMYDERLNSDEKATYFFTGKNPQWERNKPTGMKLCDYLYRKVERFAI
                     ENGVQVVDAGKCSPEQINAMIDVVSERHGESAVNEKLKAELMREYNSRYFNVPVPELPE
                     DKPARRWWPFGKK"
                     /name="hypothetical protein"
     gene            complement(3089..3820)
                     /locus_tag="P4G16_RS27200"
                     /old_locus_tag="P4G16_27195"
     CDS             complement(3089..3820)
                     /locus_tag="P4G16_RS27200"
                     /old_locus_tag="P4G16_27195"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobC family replication-relaxation protein"
                     /protein_id="WP_004152551.1"
                     /translation="MALELYNVSHAKRQARNAEKTRLTLRWLREELCSTAELVARRLGI
                     AAVQPVYRFLDSLVAKGLLVRTKYPVDGRQVSVWGLTPHGVAFSFDEDEPLADVIPFQP
                     SRVSAAHLPHRLAVQSLRLDMEARGATGWRILHRLSLKGMKVPDALAELDGKTVAFEVE
                     RTVKSRRRYQEVVSGYLFNRKANGIDEIWYICPDRATQVRVQRAILSVDEIVNPQTGEA
                     RKTAELDRERLFACFKFMTTE"
                     /name="MobC family replication-relaxation protein"
     gene            complement(3820..5784)
                     /locus_tag="P4G16_RS27205"
                     /old_locus_tag="P4G16_27200"
     CDS             complement(3820..5784)
                     /locus_tag="P4G16_RS27205"
                     /old_locus_tag="P4G16_27200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004178196.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TraM recognition domain-containing protein"
                     /protein_id="WP_004178196.1"
                     /translation="MFNTDSLAWKWHIPELARQIYPWVSWLYQEYYGLAGAFLVIGLFF
                     GLAELWAGRMRFVGLSHKERREYADRYKRDNKRPAPFSVLASLDSPGRMVRARRHVWNY
                     AYWLTGAAGLALLGGLVVAVFIESWGETVLRPDLYANADYYLLQPANLFGIAWCAGGLA
                     VGIVLARLLAFLLLDGHFAAADEAVNAKLNQESRRSSQRTGEMTDVRHLHFGEPVPVNA
                     LADFSSEQARQEQAVFLGKDEQGKPVLVPRDTWRKTNIQILGLPGSGKSVMATNALIRC
                     VRDFGDAVVYFDPKGDAWAPHVFRAHCPDFTLLDLRPGKPAQLNLFRDLDQYALKNLLI
                     AGLNLGETGDVADHYRISEQKAAKLIAEQFPQGANIQQVLAAAYALPEALKKDVKGLIT
                     RLENVADLSVLQTDSGIDVAGIINGGGCLYVIGSMDDEAVIRVQKMLFARCAQIIIARD
                     EFREWPHVSVMLDEIKYLLSKYVLNALGTLRSRDCNLLLAHQSLGDFGQCGQDLPAEFV
                     KTTVLDNTPIRWFYRAASLESAQWAAGQTGEIRVDVERRRASREAGNVEHISGDSFIQK
                     EARPLFDVNTLQHLPDGFAVMTGLGVARMAFSSPLRVERREIPLQRFPVLAKTDPLAEF
                     RPPADGGGPKADDDFAGIY"
                     /name="TraM recognition domain-containing protein"
     gene            complement(7265..7414)
                     /locus_tag="P4G16_RS27210"
                     /old_locus_tag="P4G16_27205"
     CDS             complement(7265..7414)
                     /locus_tag="P4G16_RS27210"
                     /old_locus_tag="P4G16_27205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891188.1"
                     /GO_component="GO:0019867 - outer membrane [Evidence IEA]"
                     /GO_process="GO:0019835 - cytolysis [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin release lysis protein"
                     /protein_id="WP_004152552.1"
                     /translation="MKKVKVVFLFILIFSGFLLVACQANYIRDVQGGTVAPSSSSELTG
                     IAVQ"
                     /name="colicin release lysis protein"
     gene            complement(7499..7756)
                     /locus_tag="P4G16_RS27215"
                     /old_locus_tag="P4G16_27210"
     CDS             complement(7499..7756)
                     /locus_tag="P4G16_RS27215"
                     /old_locus_tag="P4G16_27210"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin immunity family protein"
                     /protein_id="WP_004152553.1"
                     /translation="MGLKLHIHWFDKKTEEFKGGEYSKDFGDDGSVIESLGMPLKDNIN
                     NGWFDVEKSWVSILQPHFKNVIDISKFDYFVSFVYRDGNW"
                     /name="cloacin immunity family protein"
     BGC             2766..9293
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          6584..7162
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="95.361"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(3093..3820)
                     /name="MOBC"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="1.32e-150"
ORIGIN
        1 gtatgcgtcg taccccagcc cggcccgctg tttggatccg taccaccacc tgatgaaggg
       61 ccacctttac ctgatgtacc gttcacattc ccactggcct gaccaccatt gtgtcccaga
      121 cctgaattac ccggacctcg tccgtctccg ccactcatat acttttcctc tttgactttt
      181 aaaacaataa actaaaataa aatactgtac atataaccac tggttttata tacagtataa
      241 aaattacgct gccttgtttt tcatgtcaag tctgtaaatt tgcgtttttg tgaaaatgat
      301 caaaaaaaca gccactcaca ccatgcgcaa tcccctccag atgcaacaaa aaccagcaca
      361 aacggcgccg ttctccggcc tcagtatgtt ttactgaaat cattatatga gataccagaa
      421 agccccctcc gggacaggaa aagaaacggg ggtctggttc gggttgttcg gtcactgaac
      481 acggtcagaa actgatgata agatagcctg cggatatata actcaatgag aaaaaagaat
      541 taaaggtaag gagacgctca tgagacgttc cggcagcaaa ctgtgtctta tcgccatgat
      601 aacagcgaca gcaactctca ctgcctgtgc tccaaagggc agcgtggaac agcatacccg
      661 gcattacgta tatgcttcag atgacggttt tgatcccaat ttttccaccc agaaagctga
      721 cacaacacga atgatggtgc cttttttccg gcagttctgg gatatgggcg caaaggataa
      781 agcgaccgga aaatcacgga gtgatgtgca gcaacgcatt cagcagtttc acagtcagga
      841 atttttaaac tcactccaag gcacaacaca atttgcgggt accgattacc gcagcaaaga
      901 cctcacaccg aaaaaatcaa ggctactggc tgacaccatt tcagctgttt atctcgatgg
      961 ctatgaaggc agacagtaag tggatttacc ataacgcgtc attacgcgca ccgctcagac
     1021 gggctcaggg cgtttccggc ggctacggga taaaacaggc aacaaccccc ccggaaaact
     1081 gccggaaacg cgcccgataa attttatcct aatgcatgcc tatgcacgca actgcatggc
     1141 atatgttttg acgtaaaatg gatgccgtaa gccctttttt accgactttc tgcttcatca
     1201 gcctgactga cacgaccata ttctttcaga ccgccccctg ctaaacttcc ttcatattgc
     1261 cgcattaacc cgggaggctc cgcaatgagc aacactacac actacgaaaa cgccaacttt
     1321 cttcgggaac tggctgaaag cctgccccgc atactgccgg aaggtggccc ggacaaagct
     1381 gcgctgttgc agcgactggc taacgaagaa ctggcccagg cagagtatga agatcaggtt
     1441 cgcgccaaag tgaccgccgc ccgtgctgac acgcgtccgg gtatgaccac ggaacaactc
     1501 cgccagcgcc tgcatggccg ttatcaggaa ctgcgcgatg ccgtatgacg tggaatggaa
     1561 gcagggagcc atcgaggatg taacgacgct gtttgactat atcgcggaaa attcatccct
     1621 gtgggatgcg cagaacgtta ccgaccgggt tctcgctgcg gcggacaaac tggccgactt
     1681 cccgcgactc tatgaagtgg actcacgcta tggcgaggac gttcgccgga tcagtctgat
     1741 gggacagcat gtcctctatg atgttgatga ccagaccaga aaagtccggg ttctggccgt
     1801 ggtcggccag cgccagaatc cccatattgt tctctaataa ccggtgacgg ggacgcaatt
     1861 cattgcgtgg ccgtcgccgg ttggacaagc acagcgcgtc agcgttttcc ccacggccac
     1921 caccggcgcg gtgttccggc cggggtctct gctgtctccg gtttgtgttc cagcagtctc
     1981 atggactgca tttcctgccg tagcccggcc acctcctccc tgagtgcttt tatctccgcg
     2041 atcaacgcgt cggaggccat tttttcagtc tcacccgaca gtctcaactc gtcccgctcg
     2101 tgagtctcat cctgtcttaa ctcaccgtac acccggataa gctcgctggt atccaccacc
     2161 cggccgccat cagcttccgt acggtatgat acgcggcctt tcgccatatc ccgatacagg
     2221 gaacttcggg ctttacccgt cagttccgtc gcctgtctca ccgtcaccca cgccattgtc
     2281 tcaccccgct atttttgaga cagtatacct gacaggcgca caccatgccc ggaaggaaag
     2341 aatcatgaca aaacaggaaa aaacagccct caatatggct aaatttatta aggagcagtc
     2401 gctgctattg ctcgataaac tgaacgagct ggatatggat accccggccg acatgtgcga
     2461 gcggctacac gaggatgcgg aaacactctg gcaggtgatg cgggataagc tcggggagga
     2521 ataacagcac cggcatggcc ggtgctggca tttatttttt gccgaacggc caccaccggc
     2581 gggcaggttt gtcctccggc agttcaggta ccggcacgtt aaaatagcgg ctgttatatt
     2641 cccgcatcag ctccgctttc agcttctcgt tcaccgcgct ttccccgtgc cgctcactca
     2701 ccacgtcaat catcgcgtta atctgctccg gtgagcactt cccggcatca accacctgca
     2761 caccgttctc gatggcgaac cgctccacct tgcgatagag gtaatcacac agcttcattc
     2821 ctgtgggttt gttccgttcc cattgcggat ttttaccagt gaaaaagtac gtggcttttt
     2881 cgtcgctgtt gagccgctcg tcatacatcc cgatggattt catcatcgcc agatgctggg
     2941 cccggtcgac aaaacagaaa acatacgccc cggtctgcca ggcgagcacc accatatctt
     3001 ccagatgctc gctggtcggc atgatgcagc gctcgccgtt ccggtcctcc gcgtcttcaa
     3061 taaataccat gtacagcgcc ataatccctc actccgttgt cataaattta aagcacgcaa
     3121 acaaccgttc acgatccagc tctgccgttt tgcgggcctc gccggtctgt gggttcacga
     3181 tttcatccac cgacaggatt gcccgctgca ccctgacctg cgtcgcccgg tccgggcaga
     3241 tgtaccagat ttcatcgatg ccgttagctt tgcggttgaa cagatacccg gacaccactt
     3301 cctgataccg gcgacggctc ttgacggtgc gctccacctc aaacgccacc gttttaccgt
     3361 ccagctccgc cagggcgtcc ggcactttca tgcctttaag actcagacgg tgcagaatgc
     3421 gccagccggt ggcccctctg gcttccatat caaggcgcag ggattgcacg gccagccggt
     3481 gcggcagatg tgctgccgac acccttgacg gctgaaacgg aataacatcc gccagcggtt
     3541 cgtcctcgtc gaacgagaac gccacgccat gcggcgtcag cccccacacg ctgacctgac
     3601 ggccgtccac cggatatttg gtccggacca gcagcccttt cgccaccagg ctgtcgagga
     3661 agcggtagac cggctgcacc gccgcaatcc ccagccgccg cgcaaccagc tccgccgtgg
     3721 aacacagctc ttcccgcaac cagcgcaggg tcagccgggt tttctccgcg ttccgcgcct
     3781 gtcgtttcgc gtggctgacg ttgtacagct ccagcgccat cagtaaatcc ccgcaaaatc
     3841 atcatccgct ttcggcccgc cgccgtcggc cgggggccgg aactccgcca ggggatcggt
     3901 tttcgccagc accgggaaac gctgcaacgg gatttcccgg cgctcaaccc gcagcggact
     3961 gctgaacgcc atccgggcca cacccagccc ggtcatgacc gcgaacccgt ccggcaggtg
     4021 ttgcagggtg ttcacgtcaa acagcggccg cgcctccttc tggatgaagc tgtccccgct
     4081 gatatgctcc acgttccccg cctcccggct ggcacggcgg cgctccacgt ccaccctgat
     4141 ttccccggtc tgccccgccg cccactgcgc ggactccagg ctggccgccc ggtaaaacca
     4201 gcggatcggc gtgttatcca gtaccgtggt tttcacaaat tcagcgggca gatcctgccc
     4261 gcactgcccg aaatcgccca gcgactggtg cgcgagcaac agattgcagt cccggctgcg
     4321 cagcgtcccc agtgcgttca gtacatactt cgacagcaga tatttaattt catcgagcat
     4381 cacgctgacg tgtggccact cccggaactc gtcccgcgca atgatgattt gcgcgcagcg
     4441 ggcaaacagc attttttgca cacggatcac cgcctcgtcg tccatcgagc cgataacgta
     4501 caggcagccg ccgccgttga taatccccgc cacatcgata ccactgtccg tctgcaggac
     4561 gctcaggtca gcgacgtttt ccagcctagt gatcaacccc ttcacgtcct ttttcagggc
     4621 ctccggcagc gcgtacgccg ccgccagcac ctgctgaatg tttgccccct gcggaaactg
     4681 ctccgcaatc agcttcgccg ctttctgctc gctgatgcgg tagtggtccg ccacgtcgcc
     4741 ggtctcgccc aggttaagcc cggcaatcag caggtttttc agcgcgtact ggtcgagatc
     4801 gcggaacaga ttcagctgcg ccggtttccc cggccgcaga tccagcaggg tgaagtccgg
     4861 acagtgcgcc cggaagacgt gcggcgccca tgcgtcccct ttggggtcga agtacaccac
     4921 cgcgtccccg aaatcgcgta cgcagcgaat gagcgcgttg gtggccatca cgctcttgcc
     4981 gctcccgggc aggccgagga tctgaatgtt ggtcttgcgc caggtatcac gcggaaccag
     5041 caccggcttg ccctgctcat ccttacccag aaacaccgcc tgctcctgcc gggcctgctc
     5101 cgaggaaaaa tcggccagcg cattaaccgg taccggctcc ccgaaatgca ggtggcgcac
     5161 gtcggtcatc tctcctgtcc gctggctgct gcgccggctc tcctgattca gtttcgcgtt
     5221 caccgcctcg tcagcagccg caaaatgacc gtcaagcagc aggaacgcca gcagccgcgc
     5281 caacacaatc ccgacagcca gcccgcccgc gcaccaggca atcccgaaca ggttagccgg
     5341 ctgcagcagg taataatctg cgtttgcgta gaggtccgga cgcaggacgg tttctcccca
     5401 gctctcgata aacacggcga caaccagccc ccccagaagg gccagaccgg ccgcgccggt
     5461 cagccagtac gcgtagttcc agacatgtcg acgtgccctg accatccgcc cgggcgaatc
     5521 cagcgaggcc agcaccgaaa atggcgctgg ccgtttatta tcgcgcttat agcgatcggc
     5581 atactcccgt cgctccttat gactcagccc cacaaaacgc atccgtccgg cccaaagttc
     5641 agccagaccg aaaaacaggc cgataactag gaaagccccg gccagaccgt aatactcctg
     5701 gtacagccag ctgacccacg gataaatctg ccgggccagc tccggaatgt gccacttcca
     5761 ggcaagcgaa tccgtattaa acatgttctc tctccttcag acgatggttt gccggcgtga
     5821 tgtgcagccc ccgctgcaca agccgcggac atgccccaag gcatggcggc ggcggtcacg
     5881 tccgtggtga ttgcgttcag ctttcaccac ggaggccagc ctctttccgc cccatgcgga
     5941 aaaggcgcag ccccggagga acaacgagca cgccccagcg tgtgagagga aaaggcggca
     6001 ccccagtgcg gtcttttccg gtgttccggc ccccgtcaga gttcgccata gcgagcggct
     6061 gaccacccgc aaaatcagga gcagctttgc tgcttcgcca ggtgcgtcca gcaccgtgga
     6121 tttttgtggg tggtcaggcg tgagcctgac gggggccggg tgaatttctg gcgtggccgg
     6181 cgtccagccg gacggagcca gaaagagggg gagagaccgt gcgtcggtgg cgtccagcca
     6241 gcgtaagcag gggatatccc cctgaggtca gccacgccct cgcggggatg acctgtattt
     6301 ctccgtaagg agaaaaaagc aacagagata ggttaacgta aaatgttcag cgaaaaaccg
     6361 atatgattca cctatcctgg taatttatta tcagggaata taaagactta atcaggggac
     6421 aatatgccac atcagcgcgt ccggtgtccg tcttgtaggt gccggggaaa ttgcgcctcc
     6481 tcgctcactc ggtcgctacg ctccggccgt gagactgcgg cgggcgctgc ggacacatgc
     6541 aaagttaccc acagattccg tgaataagca ggggactaac atgtgaggca aaacggcaag
     6601 gccacgcagg tggcgttttt ccataggctc cgccctcctg actgagttca cataaacaga
     6661 cgctttttcg gtgcatctgt gggagccggt ggctcaacca tgaatcagtc aggagtggcg
     6721 aaacccgaca ggacttaaag atcatcaccg tttccgatga atcgctccct cttgcgctct
     6781 cctgttccaa ccctgccgtt tcccggatac ctgttccgcc tttctccctt gcgggaagtg
     6841 tggcgctttc tcatagctca cactctggta tctcggctcg gtgtaggtcg ttcgctccaa
     6901 gctgggctgt aagcaagaac cccccgttca gcccgactgc tgcgccttat ccggtaactg
     6961 ttcacttgag tccaacccgg aaaagcacgc aaaacgccac tggcagcagc cattggtaac
     7021 tgggagttcg cagaggattt gtttagctaa acacgcggtt gctcttgaag tgtgcgccaa
     7081 agtccggcta cactggaagg acagatttgg ttgctgtgct ctgcgaaagc cagttaccac
     7141 ggttaagcag ttccccaact gacttaacct tcgatcaaac cacctcccca ggtggttttt
     7201 tcgtttacag ggcaaaagat tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc
     7261 ttttctactg aaccgcgatc cccgtcagtt cagaggagga cgatggtgcc accgttccac
     7321 cctgaacatc ccggatatag tttgcctgac atgcgaccag aagaaagcct gaaaaaatca
     7381 atataaaaag aaaaacaacc tttacctttt tcatatacct tccctgtatt taaaaacccc
     7441 ggcattcatc cctgaacacc ggaagtctgt atttcaaatc atccttgata acttttgctt
     7501 accagttacc atcccggtaa acaaaggata caaagtaatc aaatttacta atatcgatta
     7561 catttttaaa gtgtggctgt aatatcgaaa cccatgattt ttcaacatca aaccaaccat
     7621 tattaatatt atcctttaaa ggcatcccca gactttcaat gacagaacca tcatcaccga
     7681 agtcttttga gtattcacca cctttaaact cttcggtttt cttatcaaac caatgaatat
     7741 gtaatttaag ccccatattt acctcttaaa gatatttttt aatgtttcgt tttggatccg
     7801 gccctttaac ctgcttaccc gtttttggat cgaatgcccc gaggtgttcg ccatcactgg
     7861 cgcggtaccc ttcaagctca ccgtgctggg aatcccattc ataaatttta cgctttttat
     7921 caccatacca tcgggcccgc ttaccaccac caccttgttt aggggtttta ggtttaccct
     7981 ctttcaactc tcccaacccc ttaatatctt cagtcttggg atcaggaaaa taatcatggc
     8041 cgtaatcttt agttccctta cgaggttttt tcttttcctc atttaattta ttttctgcat
     8101 ccttcgcttt tttctccttt tgtttccggc tctccatcgc cccggaaagc gcagccttat
     8161 ccctggataa ggattcattc atttcgttta aagatgtctg ggcagctttt aatttctcat
     8221 tctgattctg aatatcctta tcaagatagc gaacctgatc ctgccacccg gagccatatt
     8281 catgaggcgg gttataagtc acaaaatcat ctttatttgc ctctgcctct tttacctttt
     8341 tatcggcttc ctgaacagca gcccttgcac cggggatcgc cttctctgtc gatgcaatgc
     8401 gactgtttaa ggtcgcaata tttttatctt cagcatccag ctcagctttc gctttatcat
     8461 actctctttt cagcccctct tccgggtgag cagcgtccca tgcctgctgg cgacgctttt
     8521 cttcctccag acgctgtttt acctgtgccg gagtaagaac atccgtcacc gacacataga
     8581 ccggtttctg tccgctctct ttcgggaaac gaataacggc ctcacgggag ttaccaccgg
     8641 ccgtaaaacc agccggacgt gaatcacctt tttcagcaat aatgcctttt ggcggggctt
     8701 tcgcggccgg aacaccttta ggtacgctca cctgcagaga cgggagaccc ggaatcgaca
     8761 cactgaatac ccccggacgt tttgtcggtt tcgcatccac cacaggaaca ctcattggcc
     8821 ggccggtgac aaccgcaata tgctgccgct cgtccttcac aatatccgcc acacgtttag
     8881 tgacgctgac cgtcgcctgg tccagcggca gggagctgac cggcgtctct gttaccgtgt
     8941 ctgccggcaa tgacgtcacg atttttgaca tcattttcgg atcatctttt gctatctcag
     9001 aaggcagcac tccgtaaatc gcaatccccc acagaccaaa cttaaacgga cctttcaggg
     9061 cagccagcac atcagcaaca gcggccgaca acgcatcgcc ggaaacggat aaagccagtc
     9121 cttcagcccc cggagtggcc agggcaggca gaccgaaggc catcgcggtg gccgaagact
     9181 gtccgccacc agagctcccg ctatgattgc cgctgttacc gccattacca ccgggtttac
     9241 tcccgccgtt accaaactcc cccgggttat agttatgaat atccccgtta ggt
//
