LOCUS       NZ_CP125114             9294 bp    DNA     circular CON 05-APR-2024
DEFINITION  Klebsiella pneumoniae strain 327 plasmid unnamed3, complete
            sequence.
ACCESSION   NZ_CP125114
VERSION     NZ_CP125114.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN33790406
            Assembly: GCF_037477725.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 9294)
  AUTHORS   Konanov,D.N.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-MAR-2023) Laboratory of mathematical biology and
            bioinformatics, Research Institute for Systems Biology and Medicine,
            Nauchniy proezd, Moscow 117246, Russia
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. 0.4.8
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 63x
            Sequencing Technology             :: Illumina; Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_037477725.1-RS_2024_04_05
            Annotation Date                   :: 04/05/2024 19:52:28
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,953
            CDSs (total)                      :: 5,829
            Genes (coding)                    :: 5,673
            CDSs (with protein)               :: 5,673
            Genes (RNA)                       :: 124
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 86
            ncRNAs                            :: 13
            Pseudo Genes (total)              :: 156
            CDSs (without protein)            :: 156
            Pseudo Genes (ambiguous residues) :: 0 of 156
            Pseudo Genes (frameshifted)       :: 64 of 156
            Pseudo Genes (incomplete)         :: 94 of 156
            Pseudo Genes (internal stop)      :: 24 of 156
            Pseudo Genes (multiple problems)  :: 21 of 156
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP125114.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..9294
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="327"
                     /db_xref="taxon:573"
                     /plasmid="unnamed3"
                     /geo_loc_name="Russia"
                     /collection_date="2022"
     gene            complement(join(8123..9294,1..793))
                     /locus_tag="P4G13_RS29715"
                     /old_locus_tag="P4G13_29650"
     CDS             complement(join(8123..9294,1..793))
                     /locus_tag="P4G13_RS29715"
                     /old_locus_tag="P4G13_29650"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004178196.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TraM recognition domain-containing protein"
                     /protein_id="WP_004178196.1"
                     /translation="MFNTDSLAWKWHIPELARQIYPWVSWLYQEYYGLAGAFLVIGLFF
                     GLAELWAGRMRFVGLSHKERREYADRYKRDNKRPAPFSVLASLDSPGRMVRARRHVWNY
                     AYWLTGAAGLALLGGLVVAVFIESWGETVLRPDLYANADYYLLQPANLFGIAWCAGGLA
                     VGIVLARLLAFLLLDGHFAAADEAVNAKLNQESRRSSQRTGEMTDVRHLHFGEPVPVNA
                     LADFSSEQARQEQAVFLGKDEQGKPVLVPRDTWRKTNIQILGLPGSGKSVMATNALIRC
                     VRDFGDAVVYFDPKGDAWAPHVFRAHCPDFTLLDLRPGKPAQLNLFRDLDQYALKNLLI
                     AGLNLGETGDVADHYRISEQKAAKLIAEQFPQGANIQQVLAAAYALPEALKKDVKGLIT
                     RLENVADLSVLQTDSGIDVAGIINGGGCLYVIGSMDDEAVIRVQKMLFARCAQIIIARD
                     EFREWPHVSVMLDEIKYLLSKYVLNALGTLRSRDCNLLLAHQSLGDFGQCGQDLPAEFV
                     KTTVLDNTPIRWFYRAASLESAQWAAGQTGEIRVDVERRRASREAGNVEHISGDSFIQK
                     EARPLFDVNTLQHLPDGFAVMTGLGVARMAFSSPLRVERREIPLQRFPVLAKTDPLAEF
                     RPPADGGGPKADDDFAGIY"
                     /name="TraM recognition domain-containing protein"
     gene            complement(2274..2423)
                     /locus_tag="P4G13_RS29720"
                     /old_locus_tag="P4G13_29655"
     CDS             complement(2274..2423)
                     /locus_tag="P4G13_RS29720"
                     /old_locus_tag="P4G13_29655"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891188.1"
                     /GO_component="GO:0019867 - outer membrane [Evidence IEA]"
                     /GO_process="GO:0019835 - cytolysis [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin release lysis protein"
                     /protein_id="WP_004152552.1"
                     /translation="MKKVKVVFLFILIFSGFLLVACQANYIRDVQGGTVAPSSSSELTG
                     IAVQ"
                     /name="colicin release lysis protein"
     gene            complement(2508..2765)
                     /locus_tag="P4G13_RS29725"
                     /old_locus_tag="P4G13_29660"
     CDS             complement(2508..2765)
                     /locus_tag="P4G13_RS29725"
                     /old_locus_tag="P4G13_29660"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin immunity family protein"
                     /protein_id="WP_004152553.1"
                     /translation="MGLKLHIHWFDKKTEEFKGGEYSKDFGDDGSVIESLGMPLKDNIN
                     NGWFDVEKSWVSILQPHFKNVIDISKFDYFVSFVYRDGNW"
                     /name="cloacin immunity family protein"
     gene            complement(2775..4460)
                     /locus_tag="P4G13_RS29730"
                     /old_locus_tag="P4G13_29665"
     CDS             complement(2775..4460)
                     /locus_tag="P4G13_RS29730"
                     /old_locus_tag="P4G13_29665"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin-like bacteriocin tRNase domain-containing
                     protein"
                     /protein_id="WP_004178188.1"
                     /translation="MSGGDGRGPGNSGLGHNGGQASGNVNGTSGKGGPSSGGGTDPNSG
                     PGWGTTHTPNGDIHNYNPGEFGNGGSKPGGNGGNSGNHSGSSGGGQSSATAMAFGLPAL
                     ATPGAEGLALSVSGDALSAAVADVLAALKGPFKFGLWGIAIYGVLPSEIAKDDPKMMSK
                     IVTSLPADTVTETPVSSLPLDQATVSVTKRVADIVKDERQHIAVVTGRPMSVPVVDAKP
                     TKRPGVFSVSIPGLPSLQVSVPKGVPAAKAPPKGIIAEKGDSRPAGFTAGGNSREAVIR
                     FPKESGQKPVYVSVTDVLTPAQVKQRLEEEKRRQQAWDAAHPEEGLKREYDKAKAELDA
                     EDKNIATLNSRIASTEKAIPGARAAVQEADKKVKEAEANKDDFVTYNPPHEYGSGWQDQ
                     VRYLDKDIQNQNEKLKAAQTSLNEMNESLSRDKAALSGAMESRKQKEKKAKDAENKLNE
                     EKKKPRKGTKDYGHDYFPDPKTEDIKGLGELKEGKPKTPKQGGGGKRARWYGDKKRKIY
                     EWDSQHGELEGYRASDGEHLGAFDPKTGKQVKGPDPKRNIKKYL"
                     /name="colicin-like bacteriocin tRNase domain-containing
                     protein"
     gene            4863..5282
                     /locus_tag="P4G13_RS29735"
                     /old_locus_tag="P4G13_29670"
     CDS             4863..5282
                     /locus_tag="P4G13_RS29735"
                     /old_locus_tag="P4G13_29670"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016247941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Exc2 family lipoprotein"
                     /protein_id="WP_001254601.1"
                     /translation="MRRSGSKLCLIAMITATATLTACAPKGSVEQHTRHYVYASDDGFD
                     PNFSTQKADTTRMMVPFFRQFWDMGAKDKATGKSRSDVQQRIQQFHSQEFLNSLQGTTQ
                     FAGTDYRSKDLTPKKSRLLADTISAVYLDGYEGRQ"
                     /name="Exc2 family lipoprotein"
     gene            5588..5851
                     /locus_tag="P4G13_RS29740"
                     /old_locus_tag="P4G13_29675"
     CDS             5588..5851
                     /locus_tag="P4G13_RS29740"
                     /old_locus_tag="P4G13_29675"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000072676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000072676.1"
                     /translation="MSNTTHYENANFLRELAESLPRILPEGGPDKAALLQRLANEELAQ
                     AEYEDQVRAKVTAARADTRPGMTTEQLRQRLHGRYQELRDAV"
                     /name="hypothetical protein"
     gene            5841..6140
                     /locus_tag="P4G13_RS29745"
                     /old_locus_tag="P4G13_29680"
     CDS             5841..6140
                     /locus_tag="P4G13_RS29745"
                     /old_locus_tag="P4G13_29680"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001146176.1"
                     /GO_function="GO:0008657 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) inhibitor activity
                     [Evidence IEA]; GO:0042803 - protein homodimerization
                     activity [Evidence IEA]"
                     /GO_process="GO:0030541 - plasmid partitioning [Evidence
                     IEA]; GO:0051290 - protein heterotetramerization [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_001146176.1"
                     /translation="MPYDVEWKQGAIEDVTTLFDYIAENSSLWDAQNVTDRVLAAADKL
                     ADFPRLYEVDSRYGEDVRRISLMGQHVLYDVDDQTRKVRVLAVVGQRQNPHIVL"
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            complement(6202..6579)
                     /locus_tag="P4G13_RS29750"
                     /old_locus_tag="P4G13_29685"
     CDS             complement(6202..6579)
                     /locus_tag="P4G13_RS29750"
                     /old_locus_tag="P4G13_29685"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000312627.1"
                     /translation="MAWVTVRQATELTGKARSSLYRDMAKGRVSYRTEADGGRVVDTSE
                     LIRVYGELRQDETHERDELRLSGETEKMASDALIAEIKALREEVAGLRQEMQSMRLLEH
                     KPETAETPAGTPRRWWPWGKR"
                     /name="hypothetical protein"
     gene            6648..6827
                     /locus_tag="P4G13_RS29755"
                     /old_locus_tag="P4G13_29690"
     CDS             6648..6827
                     /locus_tag="P4G13_RS29755"
                     /old_locus_tag="P4G13_29690"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rop family plasmid primer RNA-binding protein"
                     /protein_id="WP_000165971.1"
                     /translation="MTKQEKTALNMAKFIKEQSLLLLDKLNELDMDTPADMCERLHEDA
                     ETLWQVMRDKLGEE"
                     /name="Rop family plasmid primer RNA-binding protein"
     gene            complement(6855..7385)
                     /locus_tag="P4G13_RS29760"
                     /old_locus_tag="P4G13_29695"
     CDS             complement(6855..7385)
                     /locus_tag="P4G13_RS29760"
                     /old_locus_tag="P4G13_29695"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_004153058.1"
                     /translation="MALYMVFIEDAEDRNGERCIMPTSEHLEDMVVLAWQTGAYVFCFV
                     DRAQHLAMMKSIGMYDERLNSDEKATYFFTGKNPQWERNKPTGMKLCDYLYRKVERFAI
                     ENGVQVVDAGKCSPEQINAMIDVVSERHGESAVNEKLKAELMREYNSRYFNVPVPELPE
                     DKPARRWWPFGKK"
                     /name="hypothetical protein"
     gene            complement(7392..8123)
                     /locus_tag="P4G13_RS29765"
                     /old_locus_tag="P4G13_29700"
     CDS             complement(7392..8123)
                     /locus_tag="P4G13_RS29765"
                     /old_locus_tag="P4G13_29700"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobC family replication-relaxation protein"
                     /protein_id="WP_004152551.1"
                     /translation="MALELYNVSHAKRQARNAEKTRLTLRWLREELCSTAELVARRLGI
                     AAVQPVYRFLDSLVAKGLLVRTKYPVDGRQVSVWGLTPHGVAFSFDEDEPLADVIPFQP
                     SRVSAAHLPHRLAVQSLRLDMEARGATGWRILHRLSLKGMKVPDALAELDGKTVAFEVE
                     RTVKSRRRYQEVVSGYLFNRKANGIDEIWYICPDRATQVRVQRAILSVDEIVNPQTGEA
                     RKTAELDRERLFACFKFMTTE"
                     /name="MobC family replication-relaxation protein"
     BGC             1..9294
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          1593..2171
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="95.361"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(7396..8123)
                     /name="MOBC"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="1.32e-150"
ORIGIN
        1 ggccgaggat ctgaatgttg gtcttgcgcc aggtatcacg cggaaccagc accggcttgc
       61 cctgctcatc cttacccaga aacaccgcct gctcctgccg ggcctgctcc gaggaaaaat
      121 cggccagcgc attaaccggt accggctccc cgaaatgcag gtggcgcacg tcggtcatct
      181 ctcctgtccg ctggctgctg cgccggctct cctgattcag tttcgcgttc accgcctcgt
      241 cagcagccgc aaaatgaccg tcaagcagca ggaacgccag cagccgcgcc aacacaatcc
      301 cgacagccag cccgcccgcg caccaggcaa tcccgaacag gttagccggc tgcagcaggt
      361 aataatctgc gtttgcgtag aggtccggac gcaggacggt ttctccccag ctctcgataa
      421 acacggcgac aaccagcccc cccagaaggg ccagaccggc cgcgccggtc agccagtacg
      481 cgtagttcca gacatgtcga cgtgccctga ccatccgccc gggcgaatcc agcgaggcca
      541 gcaccgaaaa tggcgctggc cgtttattat cgcgcttata gcgatcggca tactcccgtc
      601 gctccttatg actcagcccc acaaaacgca tccgtccggc ccaaagttca gccagaccga
      661 aaaacaggcc gataactagg aaagccccgg ccagaccgta atactcctgg tacagccagc
      721 tgacccacgg ataaatctgc cgggccagct ccggaatgtg ccacttccag gcaagcgaat
      781 ccgtattaaa catgttctct ctccttcaga cgatggtttg ccggcgtgat gtgcagcccc
      841 cgctgcacaa gccgcggaca tgccccaagg catggcggcg gcggtcacgt ccgtggtgat
      901 tgcgttcagc tttcaccacg gaggccagcc tctttccgcc ccatgcggaa aaggcgcagc
      961 cccggaggaa caacgagcac gccccagcgt gtgagaggaa aaggcggcac cccagtgcgg
     1021 tcttttccgg tgttccggcc cccgtcagag ttcgccatag cgagcggctg accacccgca
     1081 aaatcaggag cagctttgct gcttcgccag gtgcgtccag caccgtggat ttttgtgggt
     1141 ggtcaggcgt gagcctgacg ggggccgggt gaatttctgg cgtggccggc gtccagccgg
     1201 acggagccag aaagaggggg agagaccgtg cgtcggtggc gtccagccag cgtaagcagg
     1261 ggatatcccc ctgaggtcag ccacgccctc gcggggatga cctgtatttc tccgtaagga
     1321 gaaaaaagca acagagatag gttaacgtaa aatgttcagc gaaaaaccga tatgattcac
     1381 ctatcctggt aatttattat cagggaatat aaagacttaa tcaggggaca atatgccaca
     1441 tcagcgcgtc cggtgtccgt cttgtaggtg ccggggaaat tgcgcctcct cgctcactcg
     1501 gtcgctacgc tccggccgtg agactgcggc gggcgctgcg gacacatgca aagttaccca
     1561 cagattccgt gaataagcag gggactaaca tgtgaggcaa aacggcaagg ccacgcaggt
     1621 ggcgtttttc cataggctcc gccctcctga ctgagttcac ataaacagac gctttttcgg
     1681 tgcatctgtg ggagccggtg gctcaaccat gaatcagtca ggagtggcga aacccgacag
     1741 gacttaaaga tcatcaccgt ttccgatgaa tcgctccctc ttgcgctctc ctgttccaac
     1801 cctgccgttt cccggatacc tgttccgcct ttctcccttg cgggaagtgt ggcgctttct
     1861 catagctcac actctggtat ctcggctcgg tgtaggtcgt tcgctccaag ctgggctgta
     1921 agcaagaacc ccccgttcag cccgactgct gcgccttatc cggtaactgt tcacttgagt
     1981 ccaacccgga aaagcacgca aaacgccact ggcagcagcc attggtaact gggagttcgc
     2041 agaggatttg tttagctaaa cacgcggttg ctcttgaagt gtgcgccaaa gtccggctac
     2101 actggaagga cagatttggt tgctgtgctc tgcgaaagcc agttaccacg gttaagcagt
     2161 tccccaactg acttaacctt cgatcaaacc acctccccag gtggtttttt cgtttacagg
     2221 gcaaaagatt acgcgcagaa aaaaaggatc tcaagaagat cctttgatct tttctactga
     2281 accgcgatcc ccgtcagttc agaggaggac gatggtgcca ccgttccacc ctgaacatcc
     2341 cggatatagt ttgcctgaca tgcgaccaga agaaagcctg aaaaaatcaa tataaaaaga
     2401 aaaacaacct ttaccttttt catatacctt ccctgtattt aaaaaccccg gtattcatcc
     2461 ctgaacaccg gaagtctgta tttcaaatca tccttgataa cttttgctta ccagttacca
     2521 tcccggtaaa caaaggatac aaagtaatca aatttactaa tatcgattac atttttaaag
     2581 tgtggctgta atatcgaaac ccatgatttt tcaacatcaa accaaccatt attaatatta
     2641 tcctttaaag gcatccccag actttcaatg acagaaccat catcaccgaa gtcttttgag
     2701 tattcaccac ctttaaactc ttcggttttc ttatcaaacc aatgaatatg taatttaagc
     2761 cccatattta cctcttaaag atatttttta atgtttcgtt ttggatccgg ccctttaacc
     2821 tgcttacccg tttttggatc gaatgccccg aggtgttcgc catcactggc gcggtaccct
     2881 tcaagctcac cgtgctggga atcccattca taaattttac gctttttatc accataccat
     2941 cgggcccgct taccaccacc accttgttta ggggttttag gtttaccctc tttcaactct
     3001 cccaacccct taatatcttc agtcttggga tcaggaaaat aatcatggcc gtaatcttta
     3061 gttcccttac gaggtttttt cttttcctca tttaatttat tttctgcatc cttcgctttt
     3121 ttctcctttt gtttccggct ctccatcgcc ccggaaagcg cagccttatc cctggataag
     3181 gattcattca tttcgtttaa agatgtctgg gcagctttta atttctcatt ctgattctga
     3241 atatccttat caagatagcg aacctgatcc tgccacccgg agccatattc atgaggcggg
     3301 ttataagtca caaaatcatc tttatttgcc tctgcctctt ttaccttttt atcggcttcc
     3361 tgaacagcag cccttgcacc ggggatcgcc ttctctgtcg atgcaatgcg actgtttaag
     3421 gtcgcaatat ttttatcttc agcatccagc tcagctttcg ctttatcata ctctcttttc
     3481 agcccctctt ccgggtgagc agcgtcccat gcctgctggc gacgcttttc ttcctccaga
     3541 cgctgtttta cctgtgccgg agtaagaaca tccgtcaccg acacatagac cggtttctgt
     3601 ccgctctctt tcgggaaacg aataacggct tcacgggagt taccaccggc cgtaaaacca
     3661 gccggacgtg aatcaccttt ttcagcaata atgccttttg gcggggcttt cgcggccgga
     3721 acacctttag gtacgctcac ctgcagagac gggagacccg gaatcgacac actgaatacc
     3781 cccggacgtt ttgtcggttt cgcatccacc acaggaacac tcattggccg gccggtgaca
     3841 accgcaatat gctgccgctc gtccttcaca atatccgcca cacgtttagt gacgctgacc
     3901 gtcgcctggt ccagcggcag ggagctgacc ggcgtctccg ttaccgtgtc tgccggcaat
     3961 gacgtcacga tttttgacat cattttcgga tcatcttttg ctatctcaga aggcagcact
     4021 ccgtaaatcg caatccccca cagaccaaac ttaaacggac ctttcagggc agccagcaca
     4081 tcagcaacag cggccgacaa cgcatcgccg gaaacggata aagccagtcc ttcagccccc
     4141 ggagtggcca aggccggcag accgaaggcc atcgcggtgg ccgaagactg tccgccacca
     4201 gagctcccgc tatgattgcc gctgttaccg ccattaccac cgggtttact cccgccgtta
     4261 ccaaactccc ccgggttata gttatgaata tccccgttag gtgtatgcgt cgtaccccag
     4321 cccggcccgc tgtttggatc cgtaccacca cctgatgaag ggccaccttt acctgatgta
     4381 ccgttcacat tcccactggc ctgaccacca ttgtgtccca gacctgaatt acccggacct
     4441 cgtccgtctc cgccactcat atacttttcc tctttgactt ttaaaacaat aaactaaaat
     4501 aaaatactgt acacataacc actggtttta tatacagtat aaaaattacg ctgccttgtt
     4561 tttcatgtca agtctgtaaa tttgcgtttt tgtgaaaatg atcaaaaaaa cagccactca
     4621 caccatgcgc aatcccctcc agatgcaaca aaaaccagca caaacggcgc cgttctccgg
     4681 cctcagtatg ttttactgaa atcattatat gagataccag aaagccccct ccgggacagg
     4741 aaaagaaacg gggggtctgg ttcgggttgt tcggtcactg aacacggtca gaaactgatg
     4801 ataagatagc ctgcggatat ataactcaat gagaaaaaag aattaaaggt aaggagacgc
     4861 tcatgagacg ttccggcagc aaactgtgtc ttatcgccat gataacagcg acagcaactc
     4921 tcactgcctg tgctccaaag ggcagcgtgg aacagcatac ccggcattac gtatatgctt
     4981 cagatgacgg ttttgatccc aatttttcca cccagaaagc tgacacaaca cgaatgatgg
     5041 tgcctttttt ccggcagttc tgggatatgg gcgcaaagga taaagcgacc ggaaaatcac
     5101 ggagtgatgt gcagcaacgc attcagcagt ttcacagtca ggaattttta aactcactcc
     5161 aaggcacaac acaatttgcg ggtaccgatt accgcagcaa agacctcaca ccgaaaaaat
     5221 caaggctact ggctgacacc atttcagctg tttatctcga tggctatgaa ggcagacagt
     5281 aagtggattt accataacgc gtcattacgc gcaccgctca gacgggctca gggcgtttcc
     5341 ggcggctacg ggataaaaca ggcaacaacc cccccggaaa actgccggaa acgcgcccga
     5401 taaattttat cctaatgcat gcctatgcac gcaactgcat ggcatatgtt ttgacgtaaa
     5461 atggatgccg taagcccttt tttaccgact ttctgcttca tcagcctgac tgacacgacc
     5521 atattctttc agaccgcccc ctgctaaact tccttcatat tgccgcatta acccgggagg
     5581 ctccgcaatg agcaacacta cacactacga aaacgccaac tttcttcggg aactggctga
     5641 aagcctgccc cgcatactgc cggaaggtgg cccggacaaa gctgcgctgt tgcagcgact
     5701 ggctaacgaa gaactggccc aggcagagta tgaagatcag gttcgcgcca aagtgaccgc
     5761 cgcccgtgct gacacgcgtc cgggtatgac cacggaacaa ctccgccagc gcctgcatgg
     5821 ccgttatcag gaactgcgcg atgccgtatg acgtggaatg gaagcaggga gccatcgagg
     5881 atgtaacgac gctgtttgac tatatcgcgg aaaattcatc cctgtgggat gcgcagaacg
     5941 ttaccgaccg ggttctcgct gcggcggaca aactggccga cttcccgcga ctctatgaag
     6001 tggactcacg ctatggcgag gacgttcgcc ggatcagtct gatgggacag catgtcctct
     6061 atgatgttga tgaccagacc agaaaagtcc gggttctggc cgtggtcggc cagcgccaga
     6121 atccccatat tgttctctaa taaccggtga cggggacgca attcattgcg tggccgtcgc
     6181 cggttggaca agcacagcgc gtcagcgttt tccccacggc caccaccggc gcggtgttcc
     6241 ggccggggtc tctgctgtct ccggtttgtg ttccagcagt ctcatggact gcatttcctg
     6301 ccgtagcccg gccacctcct ccctgagtgc ttttatctcc gcgatcaacg cgtcggaggc
     6361 cattttttca gtctcacccg acagtctcaa ctcgtcccgc tcgtgagtct catcctgtct
     6421 taactcaccg tacacccgga taagctcgct ggtatccacc acccggccgc catcagcttc
     6481 cgtacggtat gatacgcggc ctttcgccat atcccgatac agggaacttc gggctttacc
     6541 cgtcagttcc gtcgcctgtc tcaccgtcac ccacgccatt gtctcacccc gctatttttg
     6601 agacagtata cctgacaggc gcacaccatg cccggaagga aagaatcatg acaaaacagg
     6661 aaaaaacagc cctcaatatg gctaaattta ttaaggagca gtcgctgcta ttgctcgata
     6721 aactgaatga gctggatatg gataccccgg ccgacatgtg cgagcggcta cacgaggatg
     6781 cggaaacact ctggcaggtg atgcgggata agctcgggga ggaataacag caccggcatg
     6841 gccggtgctg gcatttattt tttgccgaac ggccaccacc ggcgggcagg tttgtcctcc
     6901 ggcagttcag gtaccggcac gttaaaatag cggctgttat attcccgcat cagctccgct
     6961 ttcagcttct cgttcaccgc gctttccccg tgccgctcac tcaccacgtc aatcatcgcg
     7021 ttaatctgct ccggtgagca cttcccggca tcaaccacct gcacaccgtt ctcgatggcg
     7081 aaccgctcca ccttgcgata gaggtaatca cacagcttca ttcctgtggg tttgttccgt
     7141 tcccattgcg gatttttacc agtgaaaaag tacgtggctt tttcgtcgct gttgagccgc
     7201 tcgtcataca tcccgatgga tttcatcatc gccagatgct gggcccggtc gacaaaacag
     7261 aaaacatacg ccccggtctg ccaggcgagc accaccatat cttccagatg ctcgctggtc
     7321 ggcatgatgc agcgctcgcc gttccggtcc tccgcgtctt caataaatac catgtacagc
     7381 gccataatcc ctcactccgt tgtcataaat ttaaagcacg caaacaaccg ttcacgatcc
     7441 agctctgccg ttttgcgggc ctcgccggtc tgtgggttca cgatttcatc caccgacagg
     7501 attgcccgct gcaccctgac ctgcgtcgcc cggtccgggc agatgtacca gatttcatcg
     7561 atgccgttag ctttgcggtt gaacagatac ccggacacca cttcctgata ccggcgacgg
     7621 ctcttgacgg tgcgctccac ctcaaacgcc accgttttac cgtccagctc cgccagggcg
     7681 tccggcactt tcatgccttt aagactcaga cggtgcagaa tgcgccagcc ggtggcccct
     7741 ctggcttcca tatcaaggcg cagggattgc acggccagcc ggtgcggcag atgtgctgcc
     7801 gacacccttg acggctgaaa cggaataaca tccgccagcg gttcgtcctc gtcgaacgag
     7861 aacgccacgc catgcggcgt cagcccccac acgctgacct gacggccgtc caccggatat
     7921 ttggtccgga ccagcagccc tttcgccacc aggctgtcga ggaagcggta gaccggctgc
     7981 accgccgcaa tccccagccg ccgcgcaacc agctccgccg tggaacacag ctcttcccgc
     8041 aaccagcgca gggtcagccg ggttttctcc gcgttccgcg cctgtcgttt cgcgtggctg
     8101 acgttgtaca gctccagcgc catcagtaaa tccccgcaaa atcatcatcc gctttcggcc
     8161 cgccgccgtc ggccgggggc cggaactccg ccaggggatc ggttttcgcc agcaccggga
     8221 aacgctgcaa cgggatttcc cggcgctcaa cccgcagcgg actgctgaac gccatccggg
     8281 ccacacccag cccggtcatg accgcgaacc cgtccggcag gtgttgcagg gtgttcacgt
     8341 caaacagcgg ccgcgcctcc ttctggatga agctgtcccc gctgatatgc tccacgttcc
     8401 ccgcctcccg gctggcacgg cggcgctcca cgtccaccct gatttccccg gtctgccccg
     8461 ccgcccactg cgcggactcc aggctggccg cccggtaaaa ccagcggatc ggcgtgttat
     8521 ccagtaccgt ggttttcaca aattcagcgg gcagatcctg cccgcactgc ccgaaatcgc
     8581 ccagcgactg gtgcgcgagc aacagattgc agtcccggct gcgcagcgtc cccagtgcgt
     8641 tcagtacata cttcgacagc agatatttaa tttcatcgag catcacgctg acgtgtggcc
     8701 actcccggaa ctcgtcccgc gcaatgatga tttgcgcgca gcgggcaaac agcatttttt
     8761 gcacacggat caccgcctcg tcgtccatcg agccgataac gtacaggcag ccgccgccgt
     8821 tgataatccc cgccacatcg atgccactgt ccgtctgcag gacgctcagg tcagcgacgt
     8881 tttccagcct agtgatcaac cccttcacgt cctttttcag ggcctccggc agcgcgtacg
     8941 ccgccgccag cacctgctga atgtttgccc cctgcggaaa ctgctccgca atcagcttcg
     9001 ccgctttctg ctcgctgatg cggtagtggt ccgccacgtc gccggtctcg cccaggttaa
     9061 gcccggcaat cagcaggttt ttcagcgcgt actggtcgag atcgcggaac agattcagct
     9121 gcgccggttt ccccggccgc agatccagca gggtgaagtc cggacagtgc gcccggaaga
     9181 cgtgcggcgc ccatgcgtcc cctttggggt cgaagtacac caccgcgtcc ccgaaatcgc
     9241 gtacgcagcg aatgagcgcg ttggtggcca tcacgctctt gccgctcccg ggca
//
