LOCUS       NZ_CP117240            30891 bp    DNA     circular CON 23-MAR-2024
DEFINITION  Staphylococcus aureus strain ATCC 14458 plasmid pATCC14458_3,
            complete sequence.
ACCESSION   NZ_CP117240
VERSION     NZ_CP117240.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN32977647
            Assembly: GCF_028596165.1
KEYWORDS    RefSeq.
SOURCE      Staphylococcus aureus
  ORGANISM  Staphylococcus aureus
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 30891)
  AUTHORS   Johnson,J.D., Blankenship,H. and Soehnlen,M.
  TITLE     Long read genome assemblers struggle with small plasmids
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 30891)
  AUTHORS   Johnson,J.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (31-JAN-2023) Bureau of Laboratories, Michigan Department
            of Health and Human Services, 3350 N Martin Luther King Blvd.,
            Lansing, MI 48906, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2022
            Assembly Method                   :: Trycycler v. v0.5.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 108x
            Sequencing Technology             :: Oxford Nanopore, Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_028596165.1-RS_2024_03_23
            Annotation Date                   :: 03/23/2024 03:22:04
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,977
            CDSs (total)                      :: 2,895
            Genes (coding)                    :: 2,826
            CDSs (with protein)               :: 2,826
            Genes (RNA)                       :: 82
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 69
            CDSs (without protein)            :: 69
            Pseudo Genes (ambiguous residues) :: 0 of 69
            Pseudo Genes (frameshifted)       :: 33 of 69
            Pseudo Genes (incomplete)         :: 41 of 69
            Pseudo Genes (internal stop)      :: 11 of 69
            Pseudo Genes (multiple problems)  :: 16 of 69
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP117240.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..30891
                     /organism="Staphylococcus aureus"
                     /mol_type="genomic DNA"
                     /strain="ATCC 14458"
                     /db_xref="taxon:1280"
                     /plasmid="pATCC14458_3"
                     /geo_loc_name="USA"
                     /collection_date="2022"
     gene            1..945
                     /locus_tag="PQQ25_RS00100"
                     /old_locus_tag="PQQ25_00100"
     CDS             1..945
                     /locus_tag="PQQ25_RS00100"
                     /old_locus_tag="PQQ25_00100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001829877.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /protein_id="WP_001132442.1"
                     /translation="MPNFEKYNLSQVKTERFYQLPKYLFEDAYFKKMSAEAKIMYALLK
                     DRFELSIQNEWVDRNNNIYFIFSNKHLCEYLGYGEQKIIKLKKELVNFNLLTQERVGLN
                     KPNRLYLLKPNYDIEASLTKELPNSQFQNNEFGSSRTVNLSGQELPNSQSNDTELNNTN
                     YIENEDNDTYDMNDIISNTLINNNHHSNHTNHQKTEFNNDALKFQVLEELPQQLQDYLS
                     KFEIREIRIIKSVLLKGKKSFNTSHDTYYRLEDVEFEIVSVLKRFKAMLLQKNETVEAM
                     QGYLMQSIKAELEETHALYMRRKNMKQYNIFNQ"
                     /name="replication initiator protein A"
     gene            1075..1263
                     /locus_tag="PQQ25_RS00105"
                     /old_locus_tag="PQQ25_00105"
     CDS             1075..1263
                     /locus_tag="PQQ25_RS00105"
                     /old_locus_tag="PQQ25_00105"
                     /inference="COORDINATES: protein motif:HMM:NF013603.4"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001559000.1"
                     /translation="MLSYGGLLKEKHKILNLDDAEDGNLINTSDEDKTTDEEEKAHSIT
                     AIWNFEKQNYYLKNLRS"
                     /name="hypothetical protein"
     gene            1268..1414
                     /locus_tag="PQQ25_RS00110"
                     /old_locus_tag="PQQ25_00110"
     CDS             1268..1414
                     /locus_tag="PQQ25_RS00110"
                     /old_locus_tag="PQQ25_00110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001092934.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001092935.1"
                     /translation="MNTKILTGMTGSSLERKINNFINDNQIEVIDIKFSSSVFYFGVMI
                     IYK"
                     /name="hypothetical protein"
     gene            1994..2182
                     /locus_tag="PQQ25_RS00115"
                     /old_locus_tag="PQQ25_00115"
     CDS             1994..2182
                     /locus_tag="PQQ25_RS00115"
                     /old_locus_tag="PQQ25_00115"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001030810.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001030803.1"
                     /translation="MNKDTMLDKGYVIATILNVFFLLGLIFISHLENLYILIPYVILMG
                     INAIYLVVKVMNFKKNN"
                     /name="hypothetical protein"
     gene            2566..3182
                     /gene="cadD"
                     /locus_tag="PQQ25_RS00120"
                     /old_locus_tag="PQQ25_00120"
                     /pseudo=""
     CDS             2566..3182
                     /gene="cadD"
                     /locus_tag="PQQ25_RS00120"
                     /old_locus_tag="PQQ25_00120"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017465246.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="cadmium resistance transporter CadD"
                     /name="cadD"
     gene            3201..3548
                     /locus_tag="PQQ25_RS00125"
                     /old_locus_tag="PQQ25_00125"
     CDS             3201..3548
                     /locus_tag="PQQ25_RS00125"
                     /old_locus_tag="PQQ25_00125"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020366422.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_000119692.1"
                     /translation="MSYENTCDVICVHEDKVNNALSFLEDDKSKKLLNILEKICDEKKL
                     KIILSLIKEDELCVCDISLILKMSVASTSHHLRLLYKNEVLDFYKDGKMAYYFIKDDGI
                     REFFSKNHEGF"
                     /name="metalloregulator ArsR/SmtB family transcription
                     factor"
     gene            3739..3879
                     /locus_tag="PQQ25_RS00130"
                     /old_locus_tag="PQQ25_00130"
     CDS             3739..3879
                     /locus_tag="PQQ25_RS00130"
                     /old_locus_tag="PQQ25_00130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001199886.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001199886.1"
                     /translation="MQYNTTRSITENQDNKTLKDMTKSGKQRPWREKKIDNVRFCCKVK
                     K"
                     /name="hypothetical protein"
     gene            complement(3914..>4015)
                     /locus_tag="PQQ25_RS00135"
                     /old_locus_tag="PQQ25_00135"
                     /pseudo=""
     CDS             complement(3914..>4015)
                     /locus_tag="PQQ25_RS00135"
                     /old_locus_tag="PQQ25_00135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="IS6 family transposase"
                     /name="IS6 family transposase"
     gene            complement(4897..5808)
                     /locus_tag="PQQ25_RS00140"
                     /old_locus_tag="PQQ25_00140"
     CDS             complement(4897..5808)
                     /locus_tag="PQQ25_RS00140"
                     /old_locus_tag="PQQ25_00140"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001838132.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protein rep"
                     /protein_id="WP_078065292.1"
                     /translation="MSNFATEPNVSYADILEILKIKKAYNVKQCGNVLEFKPTDEGYLK
                     LHKTWFCKSKLCPVCNWRRAMKNSYQAQKVIEEVIKEKPKARWLFLTLSTKNAIDGDTL
                     EQSLKHLTKAFDRLSRYKKVKQNLVGFMRSTEVTVNKNDGSYNQHMHVLLCVENAYFRK
                     KENYITQEEWVNLWQKALQVDYRPVVNIKAIKPNQKGDKDIESAIKETSKYSVKSSDFL
                     TDDDEKNQEIVSDLEKGLYRKRMLSYGGLLKQKHKILNLDDAEDGNLINTSDEDKITDE
                     EAKAHSITAIWNFEKQNYYLRH"
                     /name="protein rep"
     gene            5845..6519
                     /locus_tag="PQQ25_RS00145"
                     /old_locus_tag="PQQ25_00145"
     CDS             5845..6519
                     /locus_tag="PQQ25_RS00145"
                     /old_locus_tag="PQQ25_00145"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element ISSau6 family transposase"
                     /protein_id="WP_012816671.1"
                     /translation="MNYFRYKQFDKDVITVAVGYYLRYALSYRDISEILRERGIYVYHS
                     TIYRWVQEYAPILYQIWKKKNKQAYYKWHIDETYIKIKGQWNYLYRAIDADGHTLDISL
                     RKKRDNHSAYTFIKRLIKQFGKPQMIITNQAPSTKVAMSKVIKDFKLTPNCHCNSKYLN
                     NLIEQDHRHIKVRKISYQSINTAKNTIKGIECIYGLYKKNRRFLQIYGFSPCRVISIML
                     AS"
                     /name="IS6-like element ISSau6 family transposase"
     gene            <6579..6683
                     /locus_tag="PQQ25_RS14890"
                     /pseudo=""
     CDS             <6579..6683
                     /locus_tag="PQQ25_RS14890"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011109600.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="replication protein"
                     /name="replication protein"
     gene            8184..8792
                     /locus_tag="PQQ25_RS00150"
                     /old_locus_tag="PQQ25_00150"
     CDS             8184..8792
                     /locus_tag="PQQ25_RS00150"
                     /old_locus_tag="PQQ25_00150"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017432088.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000793183.1"
                     /translation="MKNLKSFFIKNTLVLTSTALLFSSFEPVVHAAENKEVVKTVENDN
                     VEFNELLEGQEYIWEVLSRDDEGFKMFLDEQRAFNPNFDNDVLLAKQEGALNSSVFANN
                     SMTLNSNKPTPRGPIGATLKAIKALSPSLRHGGTAISWIIKPLSRKHAVLVKKYSRKMS
                     NAIDRLDKSTKSAVENAFVKAGIPRSDAKTLTYIVFLVI"
                     /name="hypothetical protein"
     gene            9270..9365
                     /locus_tag="PQQ25_RS00155"
                     /old_locus_tag="PQQ25_00155"
     CDS             9270..9365
                     /locus_tag="PQQ25_RS00155"
                     /old_locus_tag="PQQ25_00155"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000889978.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="WP_000889979.1"
                     /translation="MLEILVHITTTVISGCIVALFTHWLRNRNDK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            9602..10276
                     /locus_tag="PQQ25_RS00160"
                     /old_locus_tag="PQQ25_00160"
     CDS             9602..10276
                     /locus_tag="PQQ25_RS00160"
                     /old_locus_tag="PQQ25_00160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS257 family transposase"
                     /protein_id="WP_001105988.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TVYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDAEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVITDQAPSTKVAMAKVIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYTLYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6-like element IS257 family transposase"
     gene            10395..10910
                     /locus_tag="PQQ25_RS00165"
                     /old_locus_tag="PQQ25_00165"
     CDS             10395..10910
                     /locus_tag="PQQ25_RS00165"
                     /old_locus_tag="PQQ25_00165"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000377078.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000377078.1"
                     /translation="MDSHLNHILSYWQGPPLEGAKTIISKYGYPQEATMSRLIWYNSGP
                     WKRTIVYKDPVPHNFPTPHLDFLKQTIDYKVPVHLYDAIAAFDGSVYLDRTTGEASAKC
                     HEEAMNFLSLNLLNDIVTGKRDVQGAKAFYAQTAEQFTKYHITSPYTEGFLFPMQYNTA
                     DLGVTYFK"
                     /name="hypothetical protein"
     gene            complement(11105..11755)
                     /gene="merB"
                     /locus_tag="PQQ25_RS00170"
                     /old_locus_tag="PQQ25_00170"
     ARG             complement(11109..11755)
                     /name="merB"
                     /gene="merB"
                     /gene_name="organomercurial lyase MerB"
                     /tool="amrfinderplus"
                     /drug_class="MERCURY"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(11837..13480)
                     /gene="merA"
                     /locus_tag="PQQ25_RS00175"
                     /old_locus_tag="PQQ25_00175"
     ARG             complement(11841..13480)
                     /name="merA"
                     /gene="merA"
                     /gene_name="mercury(II) reductase"
                     /tool="amrfinderplus"
                     /drug_class="MERCURY"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(13538..13924)
                     /gene="merT"
                     /locus_tag="PQQ25_RS00180"
                     /old_locus_tag="PQQ25_00180"
     ARG             complement(13542..13924)
                     /name="merT"
                     /gene="merT"
                     /gene_name="mercuric transport protein MerT"
                     /tool="amrfinderplus"
                     /drug_class="MERCURY"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(14012..14692)
                     /locus_tag="PQQ25_RS00185"
                     /old_locus_tag="PQQ25_00185"
     CDS             complement(14012..14692)
                     /locus_tag="PQQ25_RS00185"
                     /old_locus_tag="PQQ25_00185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000010351.1"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0017004 - cytochrome complex assembly
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cytochrome c biogenesis protein CcdA"
                     /protein_id="WP_044556615.1"
                     /translation="MSFSFLFILTAGMVAAFNPCGIALLPSYISYLIGGETKNHSFRYA
                     IFKGLGLGGAMTTGFLTIFVLAGLLIGGLGSALTGIFPILSLVMGILIALLGLGMLFGK
                     HLPIKIGSFQVKPGKWSIYFYGIAYAVTSLGCTLPAFMLVVSASLNDNSVTAVIIKFII
                     YSLGMGIVVTAITMVSLISRQLVQKFLHNYMGSIQKIAAVVIFLSVLYMAYYWYFGSGG
                     ICTF"
                     /name="cytochrome c biogenesis protein CcdA"
     gene            complement(14689..15174)
                     /locus_tag="PQQ25_RS00190"
                     /old_locus_tag="PQQ25_00190"
     CDS             complement(14689..15174)
                     /locus_tag="PQQ25_RS00190"
                     /old_locus_tag="PQQ25_00190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000746200.1"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TlpA disulfide reductase family protein"
                     /protein_id="WP_000746202.1"
                     /translation="MKKRISFTAIMTVLLIGLTACGAESDTANESKVQDIQGNPVSLPN
                     EKPTLIYFMATWCPSCIYNEEIFKEMHQLNPNDVQLITVSLDPNTDTKESLAKFKQDYG
                     GDWPHVLKNGKEIADTYGVKQLEEIVLVNSENEVFYRSVRPSFDDLKEALTQIGVEL"
                     /name="TlpA disulfide reductase family protein"
     gene            complement(15191..15598)
                     /gene="merR"
                     /locus_tag="PQQ25_RS00195"
                     /old_locus_tag="PQQ25_00195"
     CDS             complement(15191..15598)
                     /gene="merR"
                     /locus_tag="PQQ25_RS00195"
                     /old_locus_tag="PQQ25_00195"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000525462.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Hg(II)-responsive transcriptional regulator MerR"
                     /protein_id="WP_000525462.1"
                     /translation="MGMKISELAKACDVNKETVRYYERKGLIAGPPRNESGYRIYSEET
                     ADRVRFIKRMKELDFSLKEIHLLFGVVDQDGERCKDMYAFTVQKTKEIERKVQGLLRIQ
                     RLLEELKEKCPDEKAMYTCPIIETLMGGPDK"
                     /name="merR"
     gene            complement(15898..>16641)
                     /locus_tag="PQQ25_RS00200"
                     /old_locus_tag="PQQ25_00200"
                     /pseudo=""
     CDS             complement(15898..>16641)
                     /locus_tag="PQQ25_RS00200"
                     /old_locus_tag="PQQ25_00200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000163428.1"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-dependent oxidoreductase"
                     /name="FAD-dependent oxidoreductase"
     gene            16697..17371
                     /locus_tag="PQQ25_RS00205"
                     /old_locus_tag="PQQ25_00205"
     CDS             16697..17371
                     /locus_tag="PQQ25_RS00205"
                     /old_locus_tag="PQQ25_00205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS257 family transposase"
                     /protein_id="WP_001105968.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TVYRWVQEYAPILYQIWKKKHKKAYYKWHIDETYIKIKGKWSYLYRAIDAEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVITDQAPSTKVAMAKVIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYTLYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6-like element IS257 family transposase"
     gene            complement(17606..19789)
                     /gene="cadA"
                     /locus_tag="PQQ25_RS00210"
                     /old_locus_tag="PQQ25_00210"
     CDS             complement(17606..19789)
                     /gene="cadA"
                     /locus_tag="PQQ25_RS00210"
                     /old_locus_tag="PQQ25_00210"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000003267.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cadmium-translocating P-type ATPase CadA"
                     /protein_id="WP_000003264.1"
                     /translation="MSEQKVKLMEEEMNVYRVQGFTCANCAGKFEKNVKKIPGVQDAKV
                     NFGASKIDVYGNASVEELEKAGAFENLKVSPEKLANQTIQRVKDDTKAHKEEKTPFYKK
                     HSTLLFATLLIAFGYLSHFVNGEDNLVTSMLFVGSIVIGGYSLFKVGFQNLIRFDFDMK
                     TLMTVAVIGAAIIGEWAEASIVVVLFAISEALERFSMDRARQSIRSLMDIAPKEALVMR
                     NGQEIMIHVDDIAVGDIMIVKPGEKIAMDGIIINGVSAVNQAAITGESVPVAKTVDDEV
                     FAGTLNEEGLLEVKITKYVEDTTISKIIHLVEEAQGERAPAQAFVDKFAKYYTPIIMVI
                     AALVAVVPPLFFGGSWDTWVYQGLAVLVVGCPCALVISTPISIVSAIGNAAKKGVLIKG
                     GVYLEELGAIKAIAFDKTGTLTKGVPVVTDFEVLNDQVEEKELFSIITALEYRSQHPLA
                     SAIMKKAEQDNIPYSNVQVEEFTSITGRGIKGIVNGTTYYIGSPKLFKELNVSDFSLGF
                     ENNVKILQNQGKTAMIIGTEKTILGVIAVADEVRETSKNVIQKLHQLGIKQTIMLTGDN
                     QGTANAIGTHVGVSDIQSELMPQDKLDYIKKMQSEYDNVAMIGDGVNDAPALAASTVGI
                     AMGGAGTDTAIETADIALMGDDLSKLPFAVRLSRKTLNIIKANITFAIGIKIIALLLVI
                     PGWLTLWIAILSDMGATILVALNSLRLMRVKDK"
                     /name="cadA"
     gene            complement(19782..20150)
                     /gene="cadC"
                     /locus_tag="PQQ25_RS00215"
                     /old_locus_tag="PQQ25_00215"
     ARG             complement(19786..20150)
                     /name="cadC"
                     /gene="cadC"
                     /gene_name="Cd(II)/Pb(II)/Zn(II)-sensing metalloregulatory
                     transcriptional repressor CadC"
                     /tool="amrfinderplus"
                     /drug_class="CADMIUM/LEAD/ZINC"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(20713..21558)
                     /locus_tag="PQQ25_RS00220"
                     /old_locus_tag="PQQ25_00220"
     CDS             complement(20713..21558)
                     /locus_tag="PQQ25_RS00220"
                     /old_locus_tag="PQQ25_00220"
                     /EC_number="3.5.2.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000733274.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BlaZ family penicillin-hydrolyzing class A
                     beta-lactamase PC1"
                     /protein_id="WP_000733283.1"
                     /translation="MKKLIFLIVIALVLSACNSNSSHAKELNDLEKKYNAHIGVYALDT
                     KSGKEVKFNSDKRFAYASTSKAINSAILLEQVPYNKLNKKVHINKDDIVAYSPILEKYV
                     GKDITLKALIEASMTYSDNTANNKIIKEIGGIKKVKQRLKELGDKVTNPVRYEIELNYY
                     SPKSKKDTSTPAAFGKTLNKLIANGKLSKENKKFLLDLMLNNKSGDTLIKDGVPKDYKV
                     ADKSGQAITYASRNDVAFVYPKGQSEPIVLVIFTNKDNKSDKPNDKLISETAKSVMKEF
                     "
                     /name="BlaZ family penicillin-hydrolyzing class A
                     beta-lactamase PC1"
     gene            21665..23422
                     /gene="blaR1"
                     /locus_tag="PQQ25_RS00225"
                     /old_locus_tag="PQQ25_00225"
     ARG             21666..23419
                     /name="blaR1"
                     /gene="blaR1"
                     /gene_name="beta-lactam sensor/signal transducer BlaR1"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="99.83"
                     /coverage="100.0"
     gene            23412..23792
                     /gene="blaI"
                     /locus_tag="PQQ25_RS00230"
                     /old_locus_tag="PQQ25_00230"
     ARG             23413..23789
                     /name="blaI"
                     /gene="blaI"
                     /gene_name="penicillinase repressor BlaI"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            24054..24632
                     /locus_tag="PQQ25_RS00235"
                     /old_locus_tag="PQQ25_00235"
     CDS             24054..24632
                     /locus_tag="PQQ25_RS00235"
                     /old_locus_tag="PQQ25_00235"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690624.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_000690630.1"
                     /translation="MKIGYARVSTGLQNLNLQEDRLNQYGCEKIFSDHISGAKSKRPGL
                     DRAIEFARSGDTIVVWRLDRLGRNMADLITLVNELNNRGVSFHSLEENITMDKSSSTGQ
                     LLFHLFAAFAEFERNLILERSSAGRIAARARGRYGGRPEKLNKQDLTLLKTLYDNGTPI
                     KTIAEQWKVSRTTIYRYLNKLNNQENKDK"
                     /name="recombinase family protein"
     gene            24763..25371
                     /locus_tag="PQQ25_RS00240"
                     /old_locus_tag="PQQ25_00240"
     CDS             24763..25371
                     /locus_tag="PQQ25_RS00240"
                     /old_locus_tag="PQQ25_00240"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002474535.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_000635267.1"
                     /translation="MIVGYARVSSIDQNLERQLDNLKTFGVEKIFTEKQSGKSITNRPV
                     FQEALNFVRMGDRFVVESIDRLGRNYDEVINTVNYLKDKEVQLMITSLPMMNEVIGNPL
                     LDKFMKDLIIQILAMVSEQERNESKRRQAQGIQVAKEKGVYKGRPLLYSPNAKDPQKRV
                     IYHRVVEMLEEGQAISKIAKEVNITRQTVYRIKHDNGLS"
                     /name="recombinase family protein"
     gene            complement(25562..25957)
                     /locus_tag="PQQ25_RS00245"
                     /old_locus_tag="PQQ25_00245"
     CDS             complement(25562..25957)
                     /locus_tag="PQQ25_RS00245"
                     /old_locus_tag="PQQ25_00245"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_500395.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thioredoxin-dependent arsenate reductase"
                     /protein_id="WP_000358995.1"
                     /translation="MDKKTIYFICTGNSCRSQMAEGWGKEILGEGWNVYSAGIETHGVN
                     PKAIEAMKEVDIDISNHTSDLIDNDILKQSDLVVTLCSDADNNCPILPPNVKKEHWGFD
                     DPAGKEWSEFQRVRDEIKLAIEKFKLR"
                     /name="thioredoxin-dependent arsenate reductase"
     gene            complement(25975..27267)
                     /gene="arsB"
                     /locus_tag="PQQ25_RS00250"
                     /old_locus_tag="PQQ25_00250"
     ARG             complement(25979..27264)
                     /name="arsB"
                     /gene="arsB"
                     /gene_name="arsenite efflux transporter membrane subunit
                     ArsB"
                     /tool="amrfinderplus"
                     /drug_class="ARSENIC"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(27264..27578)
                     /gene="arsR"
                     /locus_tag="PQQ25_RS00255"
                     /old_locus_tag="PQQ25_00255"
     ARG             complement(27268..27578)
                     /name="arsR"
                     /gene="arsR"
                     /gene_name="As(III)-sensing metalloregulatory
                     transcriptional repressor ArsR"
                     /tool="amrfinderplus"
                     /drug_class="ARSENIC"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(27639..>27989)
                     /locus_tag="PQQ25_RS00260"
                     /old_locus_tag="PQQ25_00260"
                     /pseudo=""
     CDS             complement(27639..>27989)
                     /locus_tag="PQQ25_RS00260"
                     /old_locus_tag="PQQ25_00260"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019169163.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /name="recombinase family protein"
     gene            28304..28759
                     /locus_tag="PQQ25_RS00265"
                     /old_locus_tag="PQQ25_00265"
     CDS             28304..28759
                     /locus_tag="PQQ25_RS00265"
                     /old_locus_tag="PQQ25_00265"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_223223644.1"
                     /translation="MYIEDKLIKKKVDFYRYTLGYLFQNFALLENQTISQNLDLALKFK
                     KNKKDNMNLKKEVLKKVSLDLDIKRIVNSLSGGEQQRVALARLILKDPKIILADEPTGS
                     LDTKNGKIVIDLLLNLLDENKTMIVVTHDLDLAKRFDVIVNISELRN"
                     /name="ATP-binding cassette domain-containing protein"
     gene            <28791..28877
                     /locus_tag="PQQ25_RS14895"
                     /pseudo=""
     CDS             <28791..28877
                     /locus_tag="PQQ25_RS14895"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000145511.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="replication protein Rep"
                     /name="replication protein Rep"
     gene            28941..29283
                     /locus_tag="PQQ25_RS14900"
                     /pseudo=""
     CDS             28941..29283
                     /locus_tag="PQQ25_RS14900"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000761342.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /name="helix-turn-helix transcriptional regulator"
     gene            complement(29678..30448)
                     /locus_tag="PQQ25_RS00275"
                     /old_locus_tag="PQQ25_00275"
     CDS             complement(29678..30448)
                     /locus_tag="PQQ25_RS00275"
                     /old_locus_tag="PQQ25_00275"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001813127.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /protein_id="WP_000848988.1"
                     /translation="MKTIKMVADELNVTKQTIVNNAKNLNISFKKENGINYINDNDCLK
                     IIEKITKKERTMQNKESIKKERFNENTAEFEKHIYNNSNGFESLKTKVNELEKQIEIFE
                     TRAKNDEKYIENLTKQLDQQNSNVNTLNKLLENQQILALESNKKIQKLENQLEEERQLN
                     YSFDTATNDRQSINPQEATFTEEYQNSNQQQKKIQPIEAELNHKGITKAKKDDSSNEDV
                     LKRDDKLSEEIESGPEDREVETPKKGFWSRLFGS"
                     /name="DUF536 domain-containing protein"
     ARG             complement(25566..25957)
                     /name="arsC"
                     /gene="arsC"
                     /gene_name="thioredoxin-dependent arsenate reductase"
                     /tool="amrfinderplus"
                     /drug_class="ARSENIC"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             complement(20717..21558)
                     /name="blaPC1"
                     /gene="blaPC1"
                     /gene_name="BlaZ family penicillin-hydrolyzing class A
                     beta-lactamase PC1"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             complement(20714..21558)
                     /name="PC1 beta-lactamase (blaZ)"
                     /gene="PC1 beta-lactamase (blaZ)"
                     /gene_name="BlaZ beta-lactamase"
                     /tool="rgi"
                     /drug_class="penam"
                     /identity="96.09"
                     /coverage="100.0"
     Typing          1492..1594
                     /name="MOBQ"
                     /typing="oriT"
                     /tool="MOB-suite"
                     /identity="83.81"
                     /coverage="100.0"
                     /evalue="1.39e-18"
     Typing          complement(4695..4842)
                     /name="MOBV"
                     /typing="oriT"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="5.980000000000001e-72"
     Typing          2..945
                     /name="rep_cluster_1215"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.577"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          1076..1253
                     /name="rep_cluster_1017"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="92.179"
                     /coverage="95.0"
                     /evalue="3.73e-65"
     Typing          complement(4898..5785)
                     /name="rep_cluster_1017"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="96.738"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 atgcccaatt ttgagaaata caatttatca caagtaaaaa ctgaaagatt ttaccaactt
       61 cctaaatatt tgttcgaaga tgcatatttt aagaaaatgt cagcagaagc caaaattatg
      121 tatgcattat taaaagatcg tttcgaatta tccatccaaa atgaatgggt agatagaaat
      181 aataacattt actttatttt cagtaataaa catttgtgcg agtacttagg ttatggagaa
      241 caaaaaatca taaaattgaa aaaagagtta gtaaatttta atttattaac tcaagagcgt
      301 gttggcctta ataaaccaaa tagattatat ttattaaaac caaattatga tattgaagca
      361 agtcttacca aggaacttcc aaattcacag ttccagaaca atgaatttgg aagttctaga
      421 actgtgaatt taagtggtca agaacttcca aattcacagt ctaatgatac tgagttaaat
      481 aatactaatt atatagaaaa tgaggataat gatacgtatg atatgaatga tattatatct
      541 aatactttaa taaataataa tcatcattcg aatcatacaa atcatcaaaa aactgaattt
      601 aataatgacg cccttaagtt ccaagtactc gaagaattgc cacaacaact tcaagactat
      661 ttaagtaaat ttgaaattag agaaattcgg attattaaaa gcgtattact caaagggaaa
      721 aagtcattta atacttcaca tgatacttat tatcgtttag aagatgttga gtttgaaatt
      781 gtaagtgtat tgaaacgttt taaagcgatg ttgctacaaa agaatgaaac cgttgaagct
      841 atgcaaggtt atttaatgca atccattaaa gctgaacttg aagaaacaca tgccctttat
      901 atgcgccgta aaaacatgaa acaatataat atctttaatc aataattcaa atgattttat
      961 aacaatcaaa gagacatcaa aatattccgt taaatcatct gactttttaa ctgatgacga
     1021 cgaaaaaaat caagaaattt taagtgatct agaaaaggtt tgtatcgaaa acgtatgtta
     1081 agttatggtg gattacttaa agaaaagcat aaaattttaa acttagacga tgccgaagat
     1141 ggtaatttga ttaatacaag tgatgaagat aaaacgacag acgaagaaga aaaagcacat
     1201 tcgattacag caatttggaa tttcgaaaag caaaattatt atttaaaaaa tttaaggagt
     1261 taaaaatatg aacactaaaa ttttaactgg aatgactgga agttctttag aacgaaaaat
     1321 caataatttt attaatgata accaaatcga agtcattgat attaagtttt caagttctgt
     1381 attttatttt ggggtaatga ttatttataa ataattaaag agtttaagac attagtgatg
     1441 actgatgtct ttttttactg tttttttata aaaaagtact ggcttatttt tgtgacaaat
     1501 gcaatatatt gtgtcacaaa agtgtgacac ttaagctttt tatgacccca cataaaaata
     1561 ttgttgaagc tttgaattgt ctggctttgc cagatacccc atgtatacat ggggtcaaat
     1621 ttcccttatg ctcttacgga gttacggagt tcttagagaa aaaataaaaa ttctcgattt
     1681 tgataaaaaa tgtcttgcag gaatttagaa aaacatgggg gaagttttaa aggattttat
     1741 gctaactttt aatttgcatg taaatgggca gtgtttaaaa aaatagtcat tggttttatt
     1801 taaaattttg tttttgaaaa tagcatatat gtatttggtt catatttgcg ttttaagaga
     1861 ttatgtaggt tttagataga aaactatatg atttacccct aaatctttaa aataccccct
     1921 taaaattcaa aataaaggta tttataattt gagtaagtct tgtgataaag ttttttaaaa
     1981 aggagttttt attttgaata aagacacaat gttagataaa ggttacgtta tagcaactat
     2041 tttaaatgtt ttctttttac ttggattaat ttttatatct catttggaaa atttatatat
     2101 attaattccg tatgttattt tgatgggaat aaatgctatt tatttggttg ttaaagttat
     2161 gaatttcaaa aagaataatt agaatatttg aggggatttt gaaacgagtt tcttcttgtt
     2221 ttcacactat tttttattcc tattggtgtt gttgcttact ttttgttttt ctatgaagat
     2281 gatgattttg acgagatgga agaaaaatat gattatcatg aagataaaaa aatagacgac
     2341 gcatttatgc cgagaaaatt tattgatgtt gagaagaacc cttaactaaa cttgaagacg
     2401 aatgtcggca tagcgtgagc tattaagccg accattcgac aagttttggg attgttaggg
     2461 gttccgaggc tcaacgtcaa taaagcaatt ggaataaagc acctatgatt atttaaaaat
     2521 attagttata atacattcaa aaatattttt gaatgaggtg tatgtatgat tcaaacggtt
     2581 gtcactgctg ctattcttta tattgctaca gcatttgatt tattagtaat tttattaata
     2641 ttttttgcta gagcaaagac taaaaaagaa tatagagata tttatattgg tcaatattta
     2701 gggtctatta ttttaatatt agttagtttg tttttagctt ttgtattaaa ttatgtttca
     2761 gagaagtgga tattaggttt attgggttta ataccaattt atcttggaat taaagtggct
     2821 atttatgtga ttgtgaagga gaaaagagag ctaaaaaaga actgaatgaa aaaggattgt
     2881 ctaaattagt tggtacggtt gcaattgtta cgatagcaag ttgtggcgcc gataatattg
     2941 gtttatttgt tccgtatttt gtgacattaa gtgttactaa tttattactt actctgtttg
     3001 tctttttaat tttaattttc ttcttggtgt ttactgcaca aaaattagct aatatcccag
     3061 gaattggaga aattgttgag aaatttagtc gttggattat ggctattatt tatatagctt
     3121 taggtttatt tattattatt gaaaatgaca ctattcaaac aattttagga tttatatttt
     3181 aatttagggt gtgattttat atgagttatg aaaatacttg tgatgtgatc tgtgtacatg
     3241 aggataaagt taacaatgct ttaagttttt tagaagatga taaatctaag aaattactta
     3301 acattttaga aaaaatttgt gatgagaaga aattgaaaat catattatct ttgattaaag
     3361 aagatgagtt gtgtgtttgt gatatttctt tgatattgaa aatgagtgtt gcttcaactt
     3421 cacatcattt aaggctttta tataaaaatg aggtacttga tttttataaa gatggaaaga
     3481 tggcatatta ttttattaaa gacgatggaa taagagagtt tttctctaaa aatcatgagg
     3541 gtttttgaaa cgagtgaaac gagtttcttc ttgtcttgat actatataga aataacgttc
     3601 ttttctaaaa tccttttgaa gcgttgatat gacggcgttt catactgttt tgcttgggga
     3661 aaataaaatt tgacataaaa aaactccagt aatatgatta aggtgtctaa tctaaatcaa
     3721 tactggagtt ctttttatat gcaatataat actactagaa gtataaccga aaatcaagat
     3781 aataaaacgt taaaagatat gacgaaaagt ggaaaacaac gcccatggag agaaaagaaa
     3841 atagataatg taaggttctg ttgcaaagtt aaaaaataag tgtctaacct tatgtttaaa
     3901 gtaatacttt gtattaacta gctagcatga tgctaattac acggcatggc gaaaacccgt
     3961 agatctgaag agatctgcgg ttctttttat atagtccata aatacattca atgcctgtgt
     4021 attttattcc aattgcttta ttgtcgttga gcctcggaac ccttaacaat cccaaaactt
     4081 gtcgaatggt cggcttaata gctcacgcta tgccgacatt cgtctgcaag tttagttaag
     4141 ggttcttctc aacatcaata aattttctcg gcataaatgc gtcgtctaac tttttttata
     4201 atgtttatca aaccacgatg aaaaaaatat aaaaaagact gtataaagaa taaaccaagt
     4261 atctaaatga ttttgattca tttgcttata aataaaaaac aataaaaaaa taccaagaat
     4321 aatttgtaaa ataaataaag acctcttcaa aaaaccactc cttttaaaaa actttatctc
     4381 aggacttatt caaattataa acacctttat tttgaatttt aagagggtat tttaaagatt
     4441 tagaggtaaa tcttatagtc ttctacttaa aaatctatac aagctcttaa aacgcaaata
     4501 tgagtcaaat aaatatatgg taatttcaca aacaaaaatt tcagcaaaac cagtgactaa
     4561 ttttttaaca ctgcccattt aaatgcaaat taaaaatgag cataaaatct tttaaaactt
     4621 ccccatgttt ttctaaattc ctgcagggcg tttttatcaa aaatcaagaa atttcaattt
     4681 ttctctaaga actccgtaag agcataagga gaatttgcta tcattcaaaa ataataggtc
     4741 tggcaaagcc agacattcca agggttttaa gtaattttaa agtgatatca taaaaagctg
     4801 tagtgtcaca cttttgtgac actacataca gcatttgtca caaaaataag acagtacttt
     4861 tttacaaaaa atcaataaaa aagacatcag tcatcactaa tgtcttaaat aataattttg
     4921 cttttcaaaa ttccaaattg ccgtaattga atgtgctttt gcttcttcat ctgttatttt
     4981 atcttcatca cttgtattaa ttaaattacc atcttcggca tcgtctaagt ttaaaatttt
     5041 atgcttttgt ttaagcaatc caccataact taacatacgt tttcgatata aacctttttc
     5101 taaatcactt acaatttctt gatttttttc gtcatcgtca gttaaaaaat cagatgactt
     5161 aaccgaatat tttgatgtct ctttgattgc cgattcaata tctttatcgc ctttttgatt
     5221 aggtttaatt gctttaatat ttacaacagg tcgataatca acttgtaatg ctttttgcca
     5281 taaattaacc cattcttctt gagttatata attctctttt tttctaaaat atgcattttc
     5341 aacacataac aaaacgtgca tatgctgatt ataactaccg tcatttttat taacggtaac
     5401 ttctgttgaa cgcataaatc caacaagatt ttgtttaacc tttttatatc tactcaacct
     5461 atcaaatgct ttagttagat gcttcaaact ttgttctaaa gtatctccat ctatcgcatt
     5521 ttttgttgaa agtgttaaaa acaaccaacg tgcttttggc ttttccttaa ttacttcttc
     5581 aatcactttt tgagcttgat aactattttt catagcacgc ctccaattac aaactggaca
     5641 tagctttgat ttacaaaacc acgtcttatg taatttcaaa taaccttcat cggtcggctt
     5701 gaattctaag acgttaccac attgttttac gttataagcc ttttttattt ttaaaatttc
     5761 aagtatatct gcatagctta cattaggttc tgttgcaaag ttagaaatat agtataatag
     5821 tcaacaaaaa atgaggtgca gaggatgaat tatttcagat ataagcaatt tgacaaagat
     5881 gtcattactg tagccgttgg ctactatcta agatatgcat taagttatcg tgatatatct
     5941 gaaatattga gagaacgagg catctatgtt tatcattcaa caatttatcg atgggtacag
     6001 gaatatgctc ctattttgta tcaaatttgg aagaaaaaaa ataagcaagc ttattataaa
     6061 tggcatatag atgagacgta tatcaaaatt aaagggcaat ggaattattt atatcgcgct
     6121 attgatgcag atggccatac actagatatt tcgttacgta agaaacgaga taatcactca
     6181 gcatatacgt ttattaaacg tcttattaaa caatttggca aacctcaaat gataattaca
     6241 aaccaagccc cttcaacgaa ggtggcaatg tccaaagtga ttaaagattt taaacttacc
     6301 cccaactgtc attgtaactc taaatattta aataatctca ttgaacaaga tcatcgtcat
     6361 atcaaagtaa ggaaaataag ttatcaaagt atcaatacgg caaagaatac gatcaaaggc
     6421 attgaatgta tttatggact atataaaaag aaccgcagat ttcttcagat ctacgggttt
     6481 tcgccatgcc gtgtaattag catcatgcta gctagttaat acgaagtatt attttaaaca
     6541 taaggttaga cacttatttt ttaactttgc aacagaacca agaaatcgat ccaactgaat
     6601 acctttacca aatttattat atttggaatc agaaagagta cctggcaagt gaacttcacg
     6661 aacttaccga agaagaacaa taaaaaaata taaaaatatt ttgagagttg accacccaca
     6721 tttgtagttt acggagaacg tgggtggtca actctcaaaa tttatttctt aaaaatttat
     6781 ttgttgttct gatgagcgat gaacgactaa aaaagtataa tgctattttc tatcattaca
     6841 ctttttttat acgcttatta tactttcgtt atactctttt tgtcgctaca cgaactatgt
     6901 gatcaaacgg cacgtttgcc catttaaaat gcaaattcgg aacgatttat tgctaatttt
     6961 taaatttgca tgtaaatggg cagtacgtaa aaatcgcccg tcctggtgtc gaaaaaacga
     7021 acagaaaaaa taaaattaaa atatagtaat ctttttattt tttacaggta ggtttcccca
     7081 taatttagta ctgcatcaga aatttatctg tacttagaaa tgacgacgta ttttttctat
     7141 acgtttatga catttattct acattgatcc aaatcataaa aatgtgttta aaatgtccta
     7201 aaaaggtttt aaaaggacga tttttttata ttacgtattt ttgtactcaa aattagagaa
     7261 tgctctaaat gacctcttaa aacgcaaaaa aaaaatatat atcaaaaaga catgtatttt
     7321 taaaaaaatt gatgtgtatg atgcatgtct tttgtgtatg ttttatatac ataaagtata
     7381 tgtatacgta acctgtatgt atacataacg ttatggtttt tatacatatg agttaaaaaa
     7441 gtgatgtcac tttttttcta ggaaaaataa ctcggcactg ccgagttcac cacgttatgg
     7501 gtctgccaaa atataaaagt ggtggcactt tcccttatgc tcatgacttt atgtataaaa
     7561 gttagaggta cttttatgcc gagaaaactt tttgagagat taattttttt atttttttat
     7621 tttttacttt tattttcttc aaatattttg taaatctctt tatgagtaaa taaaagatag
     7681 aagcataaag aataaatgaa aatttgaaaa tataagttta tatgaatgtt gtagaaaatc
     7741 ttcaaaatta ttaagtttaa tacgatcata ttagcagtta taaagaatat gaataagata
     7801 atattattaa atttcttttt gtattttata tgtaaaaata ttataaaaag ttcaagaaaa
     7861 ataaatatta gataagttac tataaagaat aatgcaatat agccaatgtt ataaaacata
     7921 ttatttgaat accaatttat tgttattaaa gaacttatat ttaaattatc tgctaatgat
     7981 tggaaaccta ttatgctaaa aaatggtatt gagaatacta atacggatat aggtatgatt
     8041 attattccga gtaagaacgt tacaattata aagttcaata agtactcttt gtttactttt
     8101 ttcataataa tttaattcct tttatgtata taatatttaa taataaaaaa ttttaacatt
     8161 tataattgga ggataaaagt catatgaaga atttaaaaag tttttttatt aaaaatactt
     8221 tggtactaac atctactgca ttattatttt ctagttttga acctgtagtt catgctgcag
     8281 aaaataagga agttgttaaa acagtagaaa atgataatgt agaattcaat gaattgttag
     8341 aaggacaaga atatatttgg gaagttttat ctagagatga tgaaggattt aaaatgtttc
     8401 tagatgagca aagagctttt aatcctaatt ttgataatga tgttttacta gcaaaacaag
     8461 aaggtgcttt aaattcttca gtatttgcta ataattctat gactttaaac tcaaataagc
     8521 ctactcctag aggtcctatc ggtgcaactt taaaagctat taaggctcta tcaccttctt
     8581 tgagacatgg tggaactgct atatcttgga tcattaaacc attaagtaga aaacatgctg
     8641 ttctagtaaa aaaatattca agaaagatgt ctaatgcaat tgataggtta gataagtcta
     8701 cgaaatcagc tgttgaaaat gcttttgtta aagcaggtat accaagaagt gatgcgaaaa
     8761 ctttaactta tattgtattt ttagttattt agatattgag ctgacttgcc ctaagatttt
     8821 ataaaatctt agggcaagtt tttttctttt ttcttatctt gataaagtag tattttcaat
     8881 ttgtgattgg ggtgatgatt ttctagatac agttaaaatt aataatcata gataatgaga
     8941 gaacctacaa ttatcataag ttttcaccta aaaaggatat attaaagttt tacaaatctt
     9001 taatgcacct tttagagtgt ttttaaatct attctttaat agactataat attcactatt
     9061 tattacaccg ttttttcttt agattaatga atttaggtga tgattttgaa ctgcgtttct
     9121 tcttttgtct tgatactata aaaaacgaag ttatataaca taagacgact tatcggaagt
     9181 agatatgctt gtatattcac agatggtata ataatagagt cgcctatctc tcaggcgtca
     9241 aatttagacg cagagaggag gtgttattca tgctagaaat tcttgttcac atcacgacca
     9301 cagtcatcag tggttgtatt gttgcgttat ttacgcattg gctacgcaat cgcaacgata
     9361 aataggcgac tatagtcaca cctaaaaaat cccctcacta cggcaatagt gaggggattg
     9421 gtgtattcac gctagaattc ttgttaatca tattataaca ctggttagta gaggaatgca
     9481 aaaacataag aaacgtaagt gtaactctat aattagaatt attaattttc tttgatacta
     9541 taaaagattc tgttgcaaag ttgaatttat agtataattt taacaaaaag gagtcttctg
     9601 tatgaactat ttcagatata aacaatttaa caaggatgtt atcactgtag ccgttggcta
     9661 ctatctaaga tatgcattga gttatcgtga tatatctgaa atattaaggg aacgtggtgt
     9721 aaacgttcat cattcaacgg tctaccgttg ggttcaagaa tatgccccaa ttttgtatca
     9781 aatttggaag aaaaagcata aaaaagctta ttacaaatgg cgtattgatg agacgtacat
     9841 caaaataaaa ggaaaatgga gctatttata tcgtgccatt gatgcagagg gacatacatt
     9901 agatatttgg ttgcgtaagc aacgagataa tcattcagca tatgcgttta tcaaacgtct
     9961 cattaaacaa tttggtaaac ctcaaaaggt aattacagat caggcacctt caacgaaggt
    10021 agcaatggct aaagtaatta aagcttttaa acttaaacct gactgtcatt gtacatcgaa
    10081 atatctgaat aacctcattg agcaagatca ccgtcatatt aaagtaagaa agacaaggta
    10141 tcaaagtatc aatacagcaa agaatacttt aaaaggtatt gaatgtattt acactctata
    10201 taaaaagaac cgcaggtctc ttcagatcta cggattttcg ccatgccacg aaattagcat
    10261 catgctagca agttaagcga acactgacat gataaattag tggttagcta tattttttta
    10321 ctttgcaaca gaacccctaa aattcattta ttgggcatac aatgctttta ggcaaatgtt
    10381 taggaggtat ggcaatggat agtcatttaa atcacatttt gtcctattgg cagggaccac
    10441 cgttggaagg ggcaaaaacc ataattagta agtatggata tccccaggaa gcaacaatga
    10501 gtcgattaat ttggtacaat agcgggccat ggaaacgcac gatagtatat aaggatccag
    10561 tccctcataa cttccctacc cctcaccttg atttccttaa gcagaccatc gattataaag
    10621 tgcccgtaca cttatatgat gcgattgccg cttttgatgg aagtgtctac ttagatcgaa
    10681 ctacaggtga ggcatcagca aagtgtcatg aggaagcgat gaatttttta tctttaaact
    10741 tgttaaatga cattgtaact ggcaaacgtg atgttcaagg agcaaaagct ttctacgccc
    10801 aaactgccga acagtttacc aaatatcata taacatctcc ttatacagaa ggttttcttt
    10861 ttccaatgca atataatacg gcagaccttg gcgttacata ttttaaataa ggtgccattt
    10921 tggcacctta tttactccta tattcaagaa tccactttct cgctttatta actccccgat
    10981 ataggcacaa gcaattgatc tttttattta tttggtttcc cataaaattg gtttcactag
    11041 atagagcttc ggttacagga catcatcgta aggccaagat tgacgcaggc gtaattgcct
    11101 aagattaaat gttacaacag gacccattag taggtcctga ctcctcataa cgcgctccca
    11161 aatggcgacc cagttcaaag gcatcttcaa cgggcaaaac gctcgactca gggtgttggt
    11221 taagccagtc ttgggctgca ctcggtgaac tgaaaaagtg aacgtcgtta cagaaggccg
    11281 accgaaccga ggccatttca tctggtgtaa caatcgagac aacggctgtt gaaggctcga
    11341 cgcttacaac gcggtccggt tccaccgtca accggacgga cttaccggtg ccgtgacaag
    11401 gcgaagcgat gtggaccgtc cggccgatga gtgctgggaa cataagtgtg tcaagggcgc
    11461 accatgcata tagttgcttc ccatcaacct cgaagcgatg gggggtaggg aacagtgtga
    11521 ggccataacc gacgacacgg ccctgctcat caagttccac actaggtaga gtctgtagga
    11581 cttgcttaac ttcctcgacg ggcttcccgg tctccgccgc gatgtcctca acggggactg
    11641 gatcgccctc cgccagcatt tttagcaacg gacggaataa ccactccata gagacggctt
    11701 ccccttgatc aaaagtttga tcaagttggg ctgagaattc tgaaatattt ttcataagct
    11761 tattcctcct tatattttct ccacttcatt gttttaagtg cctcctgcaa catagcatta
    11821 gaatcaaaag gaaccattag cctgcacaac aagataattt cgatacgtct ttatcaaacg
    11881 tcaaggctgc aagctttaat ccttcagcca tcgttaaata aggcgcaaag ctatccgtaa
    11941 ggtcttcaat ggtcaatcca aattgaaccg ctaacgttgc cgcataaatc acatctccag
    12001 cattttcact cacaatgtgc gctccgatca atttctgggt ttgggcgttg actacaagtt
    12061 tatagacccc tgttgtttcg tgattgacta aggcccgcgg tacagcgtcc aacggaagga
    12121 ccgatgtttt gacatcgtaa cctttttctt ttgcctgttg ttcagtcaag ccgactgtgg
    12181 cgatcgatgg attggtgaag gttacgccgg gaacaaagcg aagatcgatt ttgcgtttcg
    12241 ctagacccaa cgcattattt gccacaatcc cgccttcata agctgcaaca taaacgaatt
    12301 gcggaccgag ggtcacatcg cccgcggcat atattcggtt attcgacgtt tgcaaatatt
    12361 cattggtcag cacttcgcct tttttccctg ttttcacacc tgctgattca aggtttaaag
    12421 tctctgtgtt cggctttctt cctgttgcca cgaggacttg atcggcttcg atgacttgtt
    12481 cttgaccgtt cacttcaata taaatgcttg tcgacttacc gttttgctca accttttgat
    12541 aagtgacccc agtgatcagg ttaagtcctt gctcagttaa ggattcatcg atggcttcgg
    12601 aaatttcagg atcgtaggtt ttaaacagac gctcgcttct ttgcatgaga gtcacttctg
    12661 ttccgaggtt gtgaaacatt tgacctaatt ccgctgcgat atagccagaa ccgatcactg
    12721 ccaatcgttg tggaacctct tttaattcga gtgcggatgt acttgttaaa taatcaacct
    12781 cattcattcc cgggatttcc ggaacagccg gagaagcccc cgttgcgatt aaaaagcttt
    12841 tagacgtgat gttttgtcca ttcacttgta tcgtcttatc gtcgataaac gaggcctcgc
    12901 cacgaatgag atcaaatcca tattcttcga tcaagtctat atatttttct tgacgcattt
    12961 gactgactaa tccatctttt tgttcggtca attgggcaag gtccgcagca ccggtactcg
    13021 tttgaagtcc ggtaaacgga ttgttttggg cgagaccgtt tatttcaccg gcacgaagca
    13081 tggtttttga cggtacacaa ccgatgttaa cgcaggtccc cccgacggtt ccccgttcta
    13141 ccatggccac tttcgccccg ttttcattgg ccttgatagc tgcagaaaac gccgcaccgc
    13201 cggaaccaat aatcagaaga tcgtaatcgc catcccgatt gaaatctaca ctgttttcag
    13261 agggctggct ttcttcctct ccgggttgat agccggctgc cgaaatattt tgcttagcct
    13321 tttcgatctg atcatcgctg agttcaaaaa tggcctcacc gcgtcggaaa tcggccgaaa
    13381 catctttagc tccggcttgt tccaatgctt cggttacatg ttcttcacag cctgtgcatg
    13441 tcatgccttg aatgggtatt ttatatgaat tttgagtcat ttgaatccct ctttctattt
    13501 aaagtttgat agacagttct gtacatttat ctcatattta tcttgtctca tgtttccgat
    13561 ccacgctctc tggaggcgta cagcaatccg ttttattttt tgtttttcca ttgccttcag
    13621 gagaattgta tttgttcttc aacaacttgc tgaggatcag agcaatcata acaatggcca
    13681 atgctgcaaa aatgccggtc aaccaccaat ttcctgtcgc accagcaaag agggcaccaa
    13741 tacctgtgct ccctaatgca acaaggagaa tcggtcctgc gcaacaaagt aaaggaacca
    13801 ataaaggaac caataatatt ccgaaaaagg cccaaacacc ccagcggtta cctttcgagc
    13861 gattctcatc catcattctc accactcttt ctaaaaaaaa ttttattctt tggttaaggt
    13921 acatacatgg cctatagcct aacttgaaat ttgttcgttt agctttttta catctttcat
    13981 ctattttttg ttacacctga tcggttggat tttaaaatgt acaaatgcca ccagaaccga
    14041 aataccagta ataagccatg tacaaaacgg agaggaaaat cacaacagct gctatttttt
    14101 ggatagaacc catatagttg tgcagaaact tctgtaccaa ttgtcgtgaa atcaatgaga
    14161 ccatcgtgat cgctgtcacc acaattccca taccaaggga gtagatgatg aacttgatga
    14221 tcacggccgt tacgctattg tcattcagcg atgcagagac caccaacata aaggctggca
    14281 aggtacaacc aagtgatgtc acggcatagg ctattccgta aaaatagata gaccatttcc
    14341 ctggcttgac ttgaaaagat cctattttaa tcggcaaatg cttcccgaat agcatgccca
    14401 accccaataa agcaatgagt atacccataa ccaatgaaag aatcggaaaa atccctgtta
    14461 gtgcgcttcc caatcctcct atcaataaac cagccaatac aaaaatcgtt aaaaaccccg
    14521 tggtcatcgc tccaccaagc cctaatcctt taaaaattgc atagcggaac gaatgattct
    14581 ttgtttcgcc tccaattaaa taggagatat aagaaggaag caaggcgata ccacaaggat
    14641 taaaggccgc aaccattcca gcggtcagaa tgaagagaaa cgaaaaactc ataattccac
    14701 tcctatttga gtcaacgctt cttttaaatc atcaaaggac ggtcgaacag aacgatagaa
    14761 tacctcattt tcagaattga ccagtacgat ctcttccaat tgtttgacgc cataggtatc
    14821 cgcaatttct ttaccattct ttaaaacatg gggccaatcc ccgccataat cctgtttaaa
    14881 tttcgcaagg ctttcttttg tatctgtgtt agggtctaaa ctaactgtga tcaattgaac
    14941 atcgttcggg tttagttgat gcatttcctt aaagatttcc tcattgtata tacaagatgg
    15001 acaccaggtt gccataaaat aaatgagtgt gggtttctca ttaggtaggc tgactggatt
    15061 tccttgaatg tcttgaacct ttgattcatt cgcggtatca gattctgctc cacaagctgt
    15121 taaaccgatt aacaacaccg tcattatagc ggtgaaggaa atgcgttttt tcattcaaat
    15181 cttcccccat ttatttatca ggccctccca ttaacgtttc aataatagga caggtataca
    15241 tcgccttttc atctggacac ttttctttta attcctctaa taaccgttgg attcgtaaca
    15301 aaccctgcac tttccgctcg atttctttgg ttttttgaac ggtaaaggcg tacatatctt
    15361 tacatctctc cccatcttga tcaaccacac caaacaacag gtggatttcc tttagcgaga
    15421 aatccaattc cttcattcgt ttaataaacc gtacccgatc tgctgtttcc tctgaatata
    15481 ttcgataccc tgattcgttt ctgggaggcc cggctatcaa tcctttccgc tcgtaatacc
    15541 gaacggtttc tttattcaca tcacacgctt tagccaattc actgattttc atccccatat
    15601 tgtcacctca ataaaaagta taaaccctgt accatagtac acggtcaagt catacattat
    15661 tttttctttt atagaataat cttataaaat aggtcagata aaaaacctta tttatcaagt
    15721 gttcacataa gcttttttag aagtttaaga ataaagatat ctgctcttca cgccaagaag
    15781 ccacattctt ccgttgaaaa atgcggctgt caaaaaagtt attttctttt tgattctaag
    15841 atcatataac aagattagac gataaagtgg tttataaaca tctcacaaaa cgcaaactta
    15901 caacatgtgt gcaatgtccg aagctgccgt tggataggca aatatcattt gtttcaattc
    15961 tttggttgaa atcccaaaac gaatggctgt tgcaaaatga ttaatcagtt catcggcttc
    16021 attactaatc aaatgagcac caacaatttg atcatgatct tcgtcaatca gcactttaaa
    16081 cgcagcaaag tcctcatttg tccgtttata cgtaaaccag tcggagatgt ttttctgctt
    16141 tactttaata ttccggccag agtttttggc ttcctcctcg ctcataccta ccgatgccat
    16201 tttaggtacg gtaaatacag cagatggaat cacgggatat tcaatttttt tgctgttccc
    16261 tttcaataaa ttagatgcta cgacatgaga atctgcactg gctacaggtg tgaggggcaa
    16321 gccatccgtt gctgcagcat ctccagctgc atagacattc gggttactta cactttgcaa
    16381 atactcatta acatggacac catgtttttt cctttctata ttcccttttt caagattcat
    16441 atctaaggca gggccccgtc cagcaccatg aataacaatg tctgcttcaa accgcgttat
    16501 atcctctttt tttcgagcgt acacatgaaa ctttccttgt tctttttcaa tggattcaac
    16561 ggaatgttga agatgtacct gtatgccaat ctctttcgac ttttctaaaa ggatatctac
    16621 aagatctata tcaaaattct ggttctgttg caaagttgaa tttatagtat aattttaaca
    16681 aaaaggaatc ttctgtatga actatttcag atataaacaa tttaacaagg atgttatcac
    16741 tgtagccgtt ggctactatc taagatatgc attgagttat cgtgatatat ctgaaatatt
    16801 aagggaacgt ggtgtaaacg ttcatcattc aacggtctac cgttgggttc aagaatatgc
    16861 cccaattttg tatcaaattt ggaagaaaaa gcataaaaaa gcttattaca aatggcatat
    16921 tgatgagacg tacatcaaaa taaaaggaaa atggagctat ttatatcgtg ccattgatgc
    16981 agagggacat acattagata tttggttgcg taagcaacga gataatcatt cagcatatgc
    17041 gtttatcaaa cgtctcatta aacaatttgg taaacctcaa aaggtaatta cagatcaggc
    17101 accttcaacg aaggtagcaa tggctaaagt aattaaagct tttaaactta aacctgactg
    17161 tcattgtaca tcgaaatatc tgaataacct cattgagcaa gatcaccgtc atattaaagt
    17221 aagaaagaca aggtatcaaa gtatcaatac agcaaagaat actttaaaag gtattgaatg
    17281 tatttacact ctatataaaa agaaccgcag gtctcttcag atctacggat tttcgccatg
    17341 ccacgaaatt agcatcatgc tagcaagtta agcgaacact gacatgataa attagtggtt
    17401 agctatattt ttactttgca acagaaccag aattaatata acgagatatc aattcctgtt
    17461 gctacatata ccgcagctgc tgtaagtatc gttgcgatca tttttccatc tccaatattt
    17521 tatattttag gggtaggact tttcttcaaa ttgaaaagcc ccccttgaat tgcgcacagc
    17581 gtgaccttac tattctgttt tctacctatt tatccttcac tctcatcagt cgtaaactat
    17641 ttaatgctac caaaatagta gctcccatat cggaaagaat cgctatccaa agggttaacc
    17701 atcccgggat aactaatagt aaggcaatta ttttaattcc gatagcaaaa gtgatgttag
    17761 ctttaatgat atttaaagtt tttcgactga gtcttactgc aaatggaagc ttacttaaat
    17821 catctcccat taatgcaata tcagctgttt caattgcagt atccgttcca gcaccgccca
    17881 ttgcaattcc aacagtagat gcagcaagtg ctggagcatc attaacgcca tcgccaatca
    17941 tagctacatt atcatactcc gattgcattt ttttaatata atctaattta tcctgtggca
    18001 tcaattcaga ctgaatatca gaaacgccta catgtgtacc gattgcattt gcagtacctt
    18061 gattatcacc tgtcagcata attgtttgct tgatacctaa ctgatgaagt ttttgaatca
    18121 catttttact tgtttcacga acctcatctg caacggcaat tacgccgaga attgtttttt
    18181 ccgttccaat aatcatggct gtttttcctt ggttttgtag gattttcaca ttgttttcaa
    18241 acccaaggct aaaatcggaa acatttaatt ccttgaaaag ttttgggctt ccaatatagt
    18301 aagtagttcc gtttacaatc ccttttatac ctcgcccagt aatcgaagtg aattcttcca
    18361 cttgtacatt agaataaggg atattatctt gctctgcctt tttcattatt gctgaagcaa
    18421 gtggatgttg tgaacgatat tctaaagctg taatgataga gaatagctct ttttcttcca
    18481 cttggtcatt taatacttca aaatctgtta ccactggtac accttttgtc agtgttcctg
    18541 ttttatcaaa tgcgattgcc ttaatggctc ctaattcttc tagatagaca ccgcctttaa
    18601 tcaacacacc ttttttagct gcatttccaa ttgccgagac aatcgagatt ggagtagaaa
    18661 taactaatgc acacggacat ccaactacaa gtaccgctaa tccttgataa acccaagtat
    18721 cccaacttcc accaaagaat aaaggtggaa cgactgcaac gagcgccgca ataaccataa
    18781 tgatcggcgt ataatatttc gcaaatttat ctacgaatgc ttgcgctgga gcgcgctccc
    18841 cttgtgcttc ctcaaccaga tgaataatct tggagatagt tgtatcctct acgtatttgg
    18901 tgatttttac ttcaagtagt ccctcttcgt taagcgtacc tgcaaatact tcatcatcta
    18961 ccgttttggc aacagggaca gattctcctg ttatagcagc ctggttgaca gccgacacac
    19021 catttataat gatcccatcc atggcaattt tctcccctgg tttgacgatc ataatatcac
    19081 ccacggcaat atcgtccaca tggatcatta tttcctgacc attccgcata acaagtgctt
    19141 cttttggggc aatatccatc aatgaacgaa tggactgtct tgctctatcc atagaaaaac
    19201 gttcaagtgc ttcactgatt gcaaagagaa cgacaacaat ggatgcctct gcccattcac
    19261 caatgatggc agctccaata actgctacgg tcatcagggt tttcatgtcg aaatcaaagc
    19321 gtatcaaatt ttgaaaacca actttaaata gtgaatatcc gccaattaca atcgaaccta
    19381 caaataacat ggaagttacg aggttatctt ctccatttac aaagtgagaa aggtaaccaa
    19441 aagcaattag tagtgtggca aacagcaatg tactatgttt tttataaaat ggtgttttct
    19501 cttctttatg agccttagtg tcatctttaa ccctttgtat cgtttgattc gctagttttt
    19561 caggagatac ttttagattc tcaaaagcac ctgctttttc aagttcttca accgatgcat
    19621 ttccatatac atcaatttta gaagcgccaa agtttacttt tgcgtcctga acgcctggaa
    19681 tctttttaac atttttctca aactttcctg cacaatttgc acatgtaaat ccttggaccc
    19741 gatagacgtt catttcttct tccattagtt taaccttttg ttcagacatt gaccttcact
    19801 tctttcttat gtgctagggc gatcatcatt atctgcctga tatgttcatc acctaaagaa
    19861 tataaagcta gttttccttc ttttctaaag ttgaccaccc cttgcttata aagcgtacgt
    19921 aaatgatgag atgcatttgc tatcgtaaca cctaagatat ttgctatatc acaaacacac
    19981 aactcttcat cctgacacag agcgtaagta atttttgctc tattttcatc ggcaatagcc
    20041 tttaaaattt ggctaacacc agaaatatca actgtttgta aatccccttg tattcgatta
    20101 accttttctt cgtcataaca aaaaatttca caagtatctt tctttttcat attatcatcc
    20161 catcttcatt caaatattta tttgagtgta ttataaccat tttcgactca tcatgcaagc
    20221 aaatatttga atgaaaataa aagaagtaag tagggcataa aattctagtc tcaaaaacga
    20281 acggttttga ccagggtatg acattagaaa ataatacatt tcaataagta aaataattta
    20341 ttaaaaaata cacttgaata agtgctattt ataaaggtta aaggcttgta gaactaaata
    20401 aattctataa gtgtcacttt gcttgatata tgagaattat ttaaccttat aaatgagaaa
    20461 aaagcaacgc actttaaata agatacgttg ctttttcgat tgatgaacac ctataattaa
    20521 actattcatc tattatttat aattttttgt atatacaata tttctagttt gttaaagaga
    20581 attaagaaaa taaatctcga aaataataga gggaaaatca gtttttgata tcaaaattat
    20641 acatgtcaac gataatacaa aatataatac aaaatataag atgttatcag tatttattat
    20701 gcatttagaa tattaaaatt ccttcattac actcttggcg gtttcactta tcaacttatc
    20761 atttggctta tcacttttat tgtctttatt cgtaaaaatg actaaaacaa taggttcaga
    20821 ttggccctta ggataaacaa aagcaacatc atttctagaa gcatatgtta ttgcttgacc
    20881 acttttatca gcaaccttat agtcttttgg aacaccgtct ttaattaaag tatctccgct
    20941 tttattattt aacattaaat caagtaagaa ttttttgttt tctttgctta attttccatt
    21001 tgcgataagt ttatttaaag tcttaccgaa agcagcaggt gttgaagtat cttttttgct
    21061 ctttggtgaa tagtaattta attctatctc atatctaact ggatttgtta ctttatctcc
    21121 tagttctttt agacgttgtt taactttttt gattccaccg atttctttta taattttatt
    21181 gtttgctgta ttatcactat atgtcattga agcctcaata agtgctttta aagtgatatc
    21241 ttttcctaca tatttttcta aaataggaga ataagcaact atatcatctt tgttaatatg
    21301 tactttttta tttaacttat tataaggtac ttgttctaac aaaatagcac tatttatcgc
    21361 ttttgaagtt gaagcatagg caaatctctt atctgaatta aattttactt ccttaccact
    21421 tttagtatct aaagcataaa caccaatatg agcattatat tttttttcta aatcatttaa
    21481 ctctttggca tgtgaactgt ttgaattaca tgcacttaaa actaaagcaa ttacaattaa
    21541 aaatattaac tttttcaaaa taaaccctcc gatattacag ttgtaatttt tataaatcaa
    21601 taatattaca attgtaatat cggtgtcaat agtttattat aaatatttga aagaaggtgt
    21661 tgaaatggct aagttattaa taatgagcat agtaagcttt tgttttatat ttctattgtt
    21721 attatttttt aggtacatat taaaacgcta ttttaattat atgttaaatt ataaagtttg
    21781 gtatctaact cttcttgcag gattaattcc tttcattcct attaaattct ctctttttaa
    21841 atttaataat gtgaataatc aagcgcccac agttgaaagt aagtcacacg acttgaacca
    21901 taacataaat accaccaaac ctattcaaga gttcgcaaca gatatccata agtttaattg
    21961 ggattcaatt gataatatct gcacagttat ttggatagtt ttagttatta ttttaagttt
    22021 taaatttttg aaagccttat tatatcttaa atatttaaag aaacagtcac tttatctaaa
    22081 cgaaaatgaa aaaaataaaa tagatacgat acttttcaac catcaatata aaaaaaatat
    22141 tgtgattcga aaagcagaga ctattcaatc tccaataact ttttggtatg ggaaatatat
    22201 tattttgatt cctagttcat attttaaaag tgtaattgac aaaagactaa aatatataat
    22261 attgcatgaa tatgctcatg ctaaaaatag agatacttta catttaatta tctttaatat
    22321 cttctctatt attatgagtt acaatccatt agtacatatt gtaaaaagaa agataattca
    22381 tgacaatgaa gtagaagccg atagatttgt ccttaataat attaacaaaa atgaatttaa
    22441 aacttatgcg gaatctatta tggactccgt attaaatgtt ccatttttta ataaaaatat
    22501 attaagccat tcatttaatg gtaaaaagtc attactcaaa agaagattaa ttaatataaa
    22561 agaagccaat ctgaaaaaac agtccaaatt aattctaatt tttatttgta tttttacttt
    22621 tttgctcatg gtaattcaaa gccagttttt gatggggcaa tccataactg attataatta
    22681 taaaaagccc ttacacaacg attaccaaat tttagataaa agtaaaattt ttggttcaaa
    22741 tagtggatct ttcgtcatgt acagcatgaa gaaagacaaa tactatattt ataacgaaaa
    22801 agaaagtaga aaaaggtatt ctcctaattc aacttataaa atttatttag ctatgtttgg
    22861 acttgaccga catattataa atgatgaaaa ttcacgtatg tcatggaatc ataagcatta
    22921 cccttttgat gcttggaata aggaacaaga tttaaataca gcaatgcaaa attcagttaa
    22981 ttggtacttc gaacgtatta gcgatcaaat accaaagaac tatactgcga ctcaactcaa
    23041 gcaattaaat tatggtaata aaaatttggg aagttataaa agctattgga tggaagatag
    23101 tttgaaaata tctaatcttg aacaagtaat agtttttaaa aatatgatgg aacaaaataa
    23161 ccattttagt aaaaaagcaa agaatcaatt atcttcttca ttattgatta agaaaaatga
    23221 aaagtatgaa ctgtatggga aaacaggtac aggtatagta aacgggaagt ataataatgg
    23281 gtggtttgta ggttacgtaa ttacaaatca tgataagtat tattttgcta cacatttatc
    23341 agatggaaag ccatctggga aaaatgctga attaatcagt gaaaaaatat taaaagaaat
    23401 gggtgtttta aatggccaat aagcaagttg aaatatctat ggctgaatgg gatgttatga
    23461 atataatatg gggtaaaaaa tcagtatcag ctaatgaaat tgtagttgaa attcaaaaat
    23521 ataaagaagt tagcgataaa acgattagaa cattaatcac aagactatat aaaaaagaga
    23581 ttataaaacg atacaaatca gagaatattt atttttactc atcaaatatt aaagaagacg
    23641 atattaaaat gaaaactgct aaaacctttc ttaataaact gtatggaggg gacatgaaaa
    23701 gtttagtgct gaattttgcg aaaaatgaag aattaaataa caaagaaatt gaagaattgc
    23761 gagacatttt aaatgatatt agtaaaaagt aattagagat atgtttcaaa cataatacat
    23821 atgtaaacta tgcttgactc ttattaaatt agttttgtta ataacattta aaatatatta
    23881 ttaaagatga gagtgtacag aaaataacca ttttctgtac actctatttt tgtgtctata
    23941 tatagctagt atacatattt taatgttcaa taacccaaca caaaatctat gttcataaat
    24001 atagttagaa ttaagttatg atacaatgaa aatacatata ggaggttcgt attttgaaaa
    24061 taggttatgc aagagtttca actggtttgc aaaatttgaa tttacaggaa gatcgattaa
    24121 atcaatatgg ttgtgaaaaa atatttagcg atcacataag tggagcaaaa agtaaacgtc
    24181 ctggtttaga tagagccatt gaatttgcga ggtcaggaga tacgattgtt gtttggagac
    24241 tagatagact aggacgtaac atggcagatt taatcacatt agttaatgaa cttaataatc
    24301 gaggcgtgag ttttcatagt ttagaagaaa atataacaat ggataaatca agttctacag
    24361 gacaattgtt atttcattta ttcgcagcat ttgcagagtt tgaacgtaat ttaattttag
    24421 aacgttcttc agcaggtcga attgcagctc gtgctagagg acgctatgga ggtcgacccg
    24481 aaaaattaaa taaacaagat ttgactttac tcaaaacact ttatgataat ggaaccccaa
    24541 ttaaaactat tgcagagcaa tggaaagttt cacgtacaac aatctatcgt tatctcaata
    24601 agttaaataa ccaagaaaat aaagataaat aaaaatatta ctaagtttta agaaagctaa
    24661 aaaactagac aggatacacc ctaatcatac aaagagattt attgaattta tagtagctta
    24721 aacgtatgat tagggtgtat attaattatg aggtgaaact aaatgattgt aggatatgct
    24781 agggtctctt ctatcgatca aaatttagaa agacagttag ataatttgaa aacgtttggc
    24841 gtggagaaaa tatttacaga aaagcaatca ggcaaatcaa ttacaaatag acctgtattt
    24901 caagaggccc taaattttgt gagaatggga gatcgattcg ttgtggagtc tattgatcgt
    24961 ttaggtcgta attatgatga agtcattaat accgttaatt atctaaagga taaagaagta
    25021 caattgatga ttaccagcct cccaatgatg aatgaagtga ttggcaatcc tttattagat
    25081 aaatttatga aagatttaat tatacagata ttagcaatgg tttcagaaca agaaagaaat
    25141 gaaagtaaac gtcgacaagc tcaagggatt caagttgcga aagaaaaagg cgtatataaa
    25201 gggcgtcctt tgctttattc accgaacgcg aaagatcccc aaaaacgtgt tatctatcat
    25261 cgagttgtcg aaatgttaga agaagggcaa gcaattagta agattgcgaa agaggttaat
    25321 attacaagac agacagttta tagaattaaa catgataatg gattatcttg ataaatggat
    25381 tgtcaatgca aatgagcgtt tctcacagcg tcccaaaata tatgttaatc atgtattatg
    25441 agattttaat aataagagag gaaaaaaaga aagcgtttgt cagttttgga tttatatggc
    25501 acaaattttg ttctttaaat ggcaaaacac ctcttattaa ctaaataaga ggtgtttatg
    25561 attatctcaa tttaaacttt tctatagcta atttaatctc gtctctaaca cgttggaatt
    25621 ctgaccattc tttacctgct ggatcatcaa aaccccaatg ctctttttta acgtttggtg
    25681 gtaaaatagg acaattattg tctgcatcac tacataacgt tacgaccaaa tctgattgtt
    25741 ttaaaatatc attatcaatc aagtctgacg tatggtttga tatatcaata tctacttctt
    25801 tcatagcttc tattgcttta ggattaacac catgtgtttc aataccagca gaatagacat
    25861 tccaaccttc acccaatatt tcctttcccc aaccttcagc catttggcta cgacaagagt
    25921 ttcctgtaca tataaaataa attgttttct tatccataat taaagcccct tttcttaaaa
    25981 tatgattagt gtaaggtata aacctaagag tgttacaaat aggactggaa tagtgatgat
    26041 aattccagtt ttaaagtatg ttccccacga aatcttcaca cctttttgtg ttaagacatg
    26101 tagccacaat aatgttgcta aagaaccaat tggcgtaatt ttaggtccta aatcagaacc
    26161 tatgacattc gcataaacca tgccttcttt taatattcct gtagcactgg attggccaat
    26221 cgctattgca tctattaaaa cagttggcat gttgttcata atcgaagata agaaagcagc
    26281 tataaagccc atacccatga tgctgctaaa taacccataa tttgaaatgt ttgttaaaac
    26341 atccccaagg atcgttgtaa tacctacatt ttttagtcca aacacaacaa gatacatacc
    26401 aatagagaat acaacgatat tccatggtgc acctttaatc acttgttttg tatgaactgc
    26461 tttagattta cgagctaata ttacaaagat aaaagcaata ataccagcaa taattgatac
    26521 aggaatttgg ataaactcgc taacaagata tccaacgagt agtactgcta atactatcca
    26581 tgaaagctta aataacttag aatctttaat tgcactttta ggatctgata gattttctgt
    26641 atcgaacgtt ttaggtatgg attttctgaa atataaccat aaaacgagaa tactagcaat
    26701 cagagagaat atattaggaa tgatcattcg gctaaaatat tcaataaatc caatatcgaa
    26761 gtaatctgca gaaacgatat taactaagtt acttacaatt aagggaagtg atgtagtatc
    26821 agcaataaaa ccactggcaa taataaaggg gaaaatcact ttttgattaa atcctagatt
    26881 ccttaccatc gctaatacaa taggcgttaa gattaaagct gcaccatcat ttgcgaaaaa
    26941 tgctgctaca attgccccaa gtaacataat aaaaacaaac atttttaagc cattaccgtt
    27001 tgaagccttg accatatgta tcgcagacca ttcaaaaaaa ccaatttcat ctaatattaa
    27061 tgaaataaga ataacagcca caaaagttaa agttgcattc caaacaatac ctgttacttc
    27121 taatacatca gaaagactta cgactcctgt aatgatagca acaacagctc caattaaagc
    27181 tgtaatacca atatctaaac cttttggttg ccaaatcaca aaggttaaag ttaaaagaaa
    27241 aattacaatt gctaaaatag tcatcaacag tcacctgatt tcacattttt acatacacat
    27301 ctttgattag atgtattaat gatgttcaag ttttggataa tatcatctaa aatagcatga
    27361 ttaagttgat accaatgttt attgccgtct tttcgtgttg taactaattc attatctact
    27421 aatgacttca tatgatgact tagtgtaggt tgtgagaatt gaaagtgttc taataagtca
    27481 caagcgcata gctcaccaca agaaagtaaa tctaatattt ctaacctact tgaatctgat
    27541 aaaattttta atattgttga tagttcttta taagacatga ataaacctcc tagatgttaa
    27601 atagattaac atctatatag attattgtct atgttatttt atttactatt ttttattcta
    27661 tatatagttt gacgtgtaat accaacttct ttagctatag tacttataga tttaccctgt
    27721 tcaagtaatt caacaactcg gtaataaact aaacgctttt gtgggtcttt agcattggga
    27781 gaatacagaa caggtctccc tttatatata cctttttctt tggcgacttg aatcccttga
    27841 gcttgtcgac gtttactttc atttctttct tgttctgaaa tcattgctaa aatttgaata
    27901 attaaatctt tcataaattt atctagtagt ggatttccaa tgacttcatt catcataggt
    27961 aaactcgtta tcatgagctg aacttctttt cgaagatttt tcgtagatat aatttgctaa
    28021 taaacttcct aaaacttaat aaagaaaaat agttaaactc atgtaatcac tccataattc
    28081 tgaagtgtct ccatgtctac gcatagacac gcatttatgc cgagaaaatt tattgtgcgt
    28141 tgagaagaac ccttaactaa acttgcagac gaatgtcggc atagcgtgag ctattaagcc
    28201 gaccattcga caagttttgg gattgttaag gggtccgcgt ctcaacatca ataaagcaat
    28261 tggaataaag caactatggt aaaattttaa aaaagaagga agcatatata ttgaagataa
    28321 gttaataaaa aagaaagtcg atttttatag atatacgtta gggtatttgt ttcaaaattt
    28381 tgctttactt gaaaatcaaa caatcagtca aaatttagat ttagccctaa agttcaaaaa
    28441 gaataaaaaa gataatatga acttaaagaa agaagtatta aaaaaggtca gcctagattt
    28501 agatatcaag agaattgtta attctctaag tggtggtgaa cagcaaagag ttgcgttggc
    28561 gagacttata ttaaaagatc cgaaaatcat tttagctgat gaacctactg ggtcattaga
    28621 tacgaaaaac ggaaaaatag tcattgattt attattaaat ctacttgatg aaaataaaac
    28681 tatgattgtc gtaacacatg atttagatct tgcgaaacga tttgatgtca tagtcaatat
    28741 ttctgagctt agaaattaag aaatattgat agatatagtt acacatagag aaaaagcaac
    28801 atcaaagaga ttacgatcca caattagaga aagaacgaga ggctttttta aaacatcttg
    28861 aactgaattg ggaataatag aaacttatta agtagtgtta gtagctttaa tttttatagt
    28921 ttgagttaag gagtgatttt atgaaattag ctgaagatat aaaagaacag agagaattaa
    28981 aaggatggtc tcaagaggaa ttaaccaata tattaaaggt ttccagacaa agtgtttcta
    29041 aatgggaaag tgctaaaaat tacccttcct tagatatttt gattgctatg agtgacttat
    29101 ttggaattac tttagatcat ttaattaaag gataagcatg ttttaaaaaa agtaatttta
    29161 gagggaaatt atagagagaa caaccgggta ccttccatag ttgattttct ttatgatttt
    29221 tggtggcttt tctttcctgt tgccgtattc ttagtttggg ctattcattc gttctttgat
    29281 tgattttgaa attgaaattt aaggaatgtc agtcataatt aaaaaaggaa aacattttta
    29341 tgacaccttg aaatgaattg ataagaatag aaaagtttaa aaaaggcaat atggaatata
    29401 tactaaaagt aacaagaatt tcgtttgtaa acgcaccaaa ccccgaacta ttggccgtag
    29461 ttcgggcttt ttatgtggtt aacataatgt ttcaatatca gatattggat acctaacttc
    29521 ttttatatat aaatcttggt tacattttgg acatttcagt ggacctgttt tcataatact
    29581 cctcctttta ttagtttaca taatcgatga ttaccagaag ttctcactat ataaaaggca
    29641 ctaaaagtta taaactttta gtgcctaatt aattatttta gctaccaaac aaacgactcc
    29701 aaaacccctt tttaggtgtt tctacttccc tgtcctcagg tccactctct atttcttcag
    29761 atagtttatc atctctcttt aatacgtctt cgtttgaact gtcatccttt ttcgctttag
    29821 ttatgccctt atgatttaat tctgcttcta ttggttgtat tttcttttgt tgttggttgc
    29881 tattttgata ttcttcagta aaagttgctt cttgcggatt aatgctttgt ctatcattag
    29941 tcgctgtatc aaaagagtaa ttaagctgtc tttcttcttc taattggttt tctagttttt
    30001 gaatcttttt attactttct aaagctaata tttgttgatt ctccaacagt ttatttaatg
    30061 tattaacatt gctattttgt tgatctagtt gtttagttaa attctcaata tatttttcgt
    30121 catttttagc tctagtttca aagatttcta tttgcttttc taattcattt acttttgttt
    30181 ttaatgactc aaaaccattt gaattattgt atatatgctt ttcaaactct gcagtatttt
    30241 cattaaatct ttcttttttt attgattctt tattttgcat tgtcctttct ttcttagtga
    30301 tcttttctat aatttttaaa caatcattat cattaatata attaattcca ttttcttttt
    30361 taaaagatat atttaagttt ttagcattat taacaatagt ttgtttagtt acattcaatt
    30421 catcagcaac cattttaata gttttcataa cattcatcct taggtacata aattggtacc
    30481 taaattttac cacctaacaa atattttttc atctttcgac atctaaattt actacctatt
    30541 tcactacttt agtacctaat tagccgttaa aaccttctat aggtgactaa ttaggtacta
    30601 aagtggtgaa tttttatcat tttaaagtta caatgttctt tcaactaaac ttaaaaagct
    30661 ttatatacaa tcttaaaagt gttaatatta ctttgtgaat attaaaagag tcgatactat
    30721 tggcgtagca tcgactctcg gtaataaaac gattcgcatt cgtctgttta tataattttt
    30781 tgatacttgt attatatata tctaatcata taagtgcaag tacaaaacat ataacctacg
    30841 taaaaattgt tttattacct ctatccaaaa agtggaaatg aggtttttat t
//
