LOCUS       NZ_CP116078            42640 bp    DNA     circular CON 25-FEB-2024
DEFINITION  Escherichia coli strain DETEC-S586 plasmid pDETEC49, complete
            sequence.
ACCESSION   NZ_CP116078
VERSION     NZ_CP116078.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN31988516
            Assembly: GCF_027944615.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Escherichia.
REFERENCE   1  (bases 1 to 42640)
  AUTHORS   Moran,R.A., Baomo,L., Doughty,E.L., Guo,Y., Ba,X., van Schaik,W.,
            Zhuo,C. and McNally,A.
  TITLE     Extended-spectrum beta-lactamase genes traverse the Escherichia coli
            populations of ICU patients, staff and environment
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 42640)
  AUTHORS   Moran,R.A., Baomo,L., Doughty,E.L., Guo,Y., Ba,X., van Schaik,W.,
            Zhuo,C. and McNally,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-JAN-2023) Institute of Microbiology and Infection,
            University of Birmingham, Institute of Microbiology and Infection,
            Birmingham B15 2TT, United Kingdom
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. 0.4.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 10x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/25/2024 01:50:10
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,261
            CDSs (total)                      :: 5,142
            Genes (coding)                    :: 4,937
            CDSs (with protein)               :: 4,937
            Genes (RNA)                       :: 119
            rRNAs                             :: 8, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 88
            ncRNAs                            :: 9
            Pseudo Genes (total)              :: 205
            CDSs (without protein)            :: 205
            Pseudo Genes (ambiguous residues) :: 0 of 205
            Pseudo Genes (frameshifted)       :: 65 of 205
            Pseudo Genes (incomplete)         :: 145 of 205
            Pseudo Genes (internal stop)      :: 38 of 205
            Pseudo Genes (multiple problems)  :: 43 of 205
            Pseudo Genes (short protein)      :: 5 of 205
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP116078.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..42640
                     /organism="Escherichia coli"
                     /mol_type="genomic DNA"
                     /strain="DETEC-S586"
                     /isolation_source="ICU staff rectal swab"
                     /db_xref="taxon:562"
                     /plasmid="pDETEC49"
                     /geo_loc_name="China: Guangzhou"
                     /collection_date="2019-09-01"
     gene            join(42331..42640,1..347)
                     /locus_tag="PIC49_RS25515"
                     /old_locus_tag="PIC49_25520"
     CDS             join(42331..42640,1..347)
                     /locus_tag="PIC49_RS25515"
                     /old_locus_tag="PIC49_25520"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001478769.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001419803.1"
                     /translation="MMIKSKKVVVIFVALSSFLLAGCDSPKDANKQNFEKAINTRLEKE
                     CITISPLGMFDSKPYPVQVAVAQANRYTSQERADEINSRQFSALDVLVKANLLTVKDTL
                     VDDVIGFTKTGKKVPGREYALTDEGKKYLKSPERPDFCVGHYKVDEIVDFTEPGDAMGM
                     KITQVNYTFSPTSIAEWAKRDDVRAAFLGLESDLKEKQTKRITLVLKNDGWSAER"
                     /name="hypothetical protein"
     gene            430..780
                     /locus_tag="PIC49_RS25520"
                     /old_locus_tag="PIC49_25525"
     CDS             430..780
                     /locus_tag="PIC49_RS25520"
                     /old_locus_tag="PIC49_25525"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001419804.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001419804.1"
                     /translation="MTLSKILTDIFRTANNLTHCKTTNQLCAGDASIALASAILSCDRY
                     SIFEQDYPRSGLIRQAVRHTGHSVQRQQFTATGCADSSKSAGKSEWRQLLQCNYLLAQS
                     GIDAAPRSHNCW"
                     /name="hypothetical protein"
     gene            923..1597
                     /locus_tag="PIC49_RS25525"
                     /old_locus_tag="PIC49_25530"
     CDS             923..1597
                     /locus_tag="PIC49_RS25525"
                     /old_locus_tag="PIC49_25530"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001419805.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SLATT domain-containing protein"
                     /protein_id="WP_228295637.1"
                     /translation="MMDKISNLFKWIFSLNPVEAVVNDPTQKLLNSMRVTSKCRYNASI
                     RLKRQSQLSFFSTTVLSLGLILIPLLQNADIHLHLPLKVLNMLQIFLAVSVLVYSVIIG
                     TAHYEIRSKQLNECGDKIKDLIRKLRLGNNKEELSTYIQMYDSVSTESENHARVDFLLA
                     SLEMKTDYKYTGLLRFWLYIRSIFLYIFPWLIPLTLVLSEIIFICDMLGVTYISTPFLT
                     GE"
                     /name="SLATT domain-containing protein"
     gene            complement(1749..2522)
                     /locus_tag="PIC49_RS25530"
                     /old_locus_tag="PIC49_25535"
     CDS             complement(1749..2522)
                     /locus_tag="PIC49_RS25530"
                     /old_locus_tag="PIC49_25535"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000418056.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_106668251.1"
                     /translation="MELDTEFRYPNVIDFFGTTLFHLCHFTTIDLHNYATYNKYSENNI
                     AKSNKRLCEEIEQRIKESDKKYHEDIIDSYHQEMQEFGDIYPPMHRKAMVITLYNFFEH
                     QIKTLCAEINMLLPKNMSESYSLSNACIKEYRKFLRREAIFDMNPGGELWKRWEDMLKV
                     EQIRHVLVHSEGEIEKHRAERLADIESYCKQKKGIRLIRHRIIIDEGYVAGLITELISL
                     FELLDRQVKVFIRRYESEHGSYEVPLPQGASRTPL"
                     /name="hypothetical protein"
     gene            2691..3116
                     /locus_tag="PIC49_RS25535"
                     /old_locus_tag="PIC49_25540"
     CDS             2691..3116
                     /locus_tag="PIC49_RS25535"
                     /old_locus_tag="PIC49_25540"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000238252.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_012300440.1"
                     /translation="MSSSAAVTVITGVLVFVGGQLIVKSAIEPYIEFKKQLGKISNLLL
                     ANQAKLANPCAVEMSEIIHELKDAAAQLMSKHSALPFYIKKFHIGFRFVPSTPEIISSA
                     QKLNLIASIHEGKSKESTYEHIAEIGRMLKIPTTYSL"
                     /name="hypothetical protein"
     gene            complement(3237..3494)
                     /locus_tag="PIC49_RS25540"
                     /old_locus_tag="PIC49_25545"
     CDS             complement(3237..3494)
                     /locus_tag="PIC49_RS25540"
                     /old_locus_tag="PIC49_25545"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000527006.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000527006.1"
                     /translation="MGNKHISASEAKKISSSVIPDADKTLDMIFGEIKLQARLGQTSFI
                     YPVHENILEQVVKVLRESGYRINSSKANENNKFIIEISWQ"
                     /name="hypothetical protein"
     gene            4051..4353
                     /locus_tag="PIC49_RS25545"
                     /old_locus_tag="PIC49_25550"
     CDS             4051..4353
                     /locus_tag="PIC49_RS25545"
                     /old_locus_tag="PIC49_25550"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004142601.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system HigB family toxin"
                     /protein_id="WP_000691019.1"
                     /translation="MKIIAIKTLRDFWTANPDAEQPLKAWVDEASKAEWKSPAEIKEQY
                     RSASILKNRRVVFNIKGNDYRLIVAIAYQRGWMFIKFIGTHKEYDKIDAETVSLE"
                     /name="type II toxin-antitoxin system HigB family toxin"
     gene            4359..4718
                     /locus_tag="PIC49_RS25550"
                     /old_locus_tag="PIC49_25555"
     CDS             4359..4718
                     /locus_tag="PIC49_RS25550"
                     /old_locus_tag="PIC49_25555"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001166027.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transcriptional regulator"
                     /protein_id="WP_001716067.1"
                     /translation="MQIKPIKTEQDYEAALRAVEPMFDNEPPADTPEGDFFEIMCVLIN
                     EYEKKHYPIEAPDPVEAIKFRMEQQGLTVKDLEPAIGKSNRVYEVLNRKRNLTLPMIRK
                     LHTMFGIPLKSLVGG"
                     /name="transcriptional regulator"
     gene            complement(5252..5500)
                     /locus_tag="PIC49_RS25555"
                     /old_locus_tag="PIC49_25560"
     CDS             complement(5252..5500)
                     /locus_tag="PIC49_RS25555"
                     /old_locus_tag="PIC49_25560"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000312658.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000312658.1"
                     /translation="MAWYIDSKNVKKNTNEKANAKYEKIWKPGEKPDHAGIYRCQACGY
                     EDLINRQCNKLPPCSNCEKKAHKNNTWKLLVRAVDAE"
                     /name="hypothetical protein"
     gene            6422..7246
                     /locus_tag="PIC49_RS25560"
                     /old_locus_tag="PIC49_25565"
     CDS             6422..7246
                     /locus_tag="PIC49_RS25560"
                     /old_locus_tag="PIC49_25565"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001487124.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA];
                     GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="tyrosine-type recombinase/integrase"
                     /protein_id="WP_106668252.1"
                     /translation="MSHLPANIFQISRSDAWNLTLSPDAARNMRDLAAQIGAGMPKYLI
                     APEVSLLLSYIDDLSIRMYFETLWNTGARLNEALALKPADFMLTPTRQYPQPVVILKTL
                     KQRIKEAERRPGRPTTRHPPLHPDPRYRKPPEPAVRLVPVLDAGYALRMREYLATWKKR
                     IKHQPVWDITSRQTPLNWINTAVARAERDGVTFSVPVTPHTFRHSYAMHLTMSGVPPRV
                     LQSLLGHRYARSTEIYTRVFSLDVLTGSGLSFTCDPQRAKQLLGYPERINDE"
                     /name="tyrosine-type recombinase/integrase"
     gene            7351..8010
                     /locus_tag="PIC49_RS25565"
                     /old_locus_tag="PIC49_25570"
     CDS             7351..8010
                     /locus_tag="PIC49_RS25565"
                     /old_locus_tag="PIC49_25570"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000516228.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="division plane positioning ATPase MipZ"
                     /protein_id="WP_000516222.1"
                     /translation="MGKIITVAGHKGGIGKSTVLCSLCVCAIRKGKTACFLETDSQGSI
                     KDFIEERKTNERLSEIPYFECYTDIPAMARKLAARFDYVFVDTPGMKSPAFVKALSCAD
                     ILFTFIEPGAGIEINTLGRLVFDIKTAQAGVNPSMKAWIVLNKCSTNPSDSEASELRRQ
                     LNDDPDWLPVPRQRIYMRTAHKKAYNSGMGVHEYDDKRGNKARGEIELLLKETDVL"
                     /name="division plane positioning ATPase MipZ"
     gene            8102..8404
                     /locus_tag="PIC49_RS25570"
                     /old_locus_tag="PIC49_25575"
     CDS             8102..8404
                     /locus_tag="PIC49_RS25570"
                     /old_locus_tag="PIC49_25575"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001096506.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001096507.1"
                     /translation="MAKLPKKIDQEIKPLDLRQFVSSAAQKPASASAVTRINLTMTDDD
                     LDTAQVFQNKYGASRAEVIRAALAALRLVSAEERRRLFDDIRKNSPKAGRPTVNK"
                     /name="hypothetical protein"
     gene            8643..9876
                     /locus_tag="PIC49_RS25575"
                     /old_locus_tag="PIC49_25580"
                     /pseudo=""
     CDS             8643..9876
                     /locus_tag="PIC49_RS25575"
                     /old_locus_tag="PIC49_25580"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_031587700.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="IS1380 family transposase"
                     /name="IS1380 family transposase"
     gene            10126..11001
                     /locus_tag="PIC49_RS25580"
                     /old_locus_tag="PIC49_25585"
     CDS             10126..11001
                     /locus_tag="PIC49_RS25580"
                     /old_locus_tag="PIC49_25585"
                     /EC_number="3.5.2.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032492044.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="extended-spectrum class A beta-lactamase
                     CTX-M-24"
                     /protein_id="WP_012579082.1"
                     /translation="MVTKRVQRMMFAAAACIPLLLGSAPLYAQTSAVQQKLAALEKSSG
                     GRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPAD
                     LVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETF
                     RLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAA
                     SIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAERRRDVLA
                     SAARIIAEGL"
                     /name="extended-spectrum class A beta-lactamase CTX-M-24"
     gene            11036..>11728
                     /locus_tag="PIC49_RS25585"
                     /old_locus_tag="PIC49_25590"
                     /pseudo=""
     CDS             11036..>11728
                     /locus_tag="PIC49_RS25585"
                     /old_locus_tag="PIC49_25590"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_005224844.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="IS5 family transposase"
                     /name="IS5 family transposase"
     gene            11858..12073
                     /locus_tag="PIC49_RS26320"
     CDS             11858..12073
                     /locus_tag="PIC49_RS26320"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000399458.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000399458.1"
                     /translation="MEHCIFDLGIIDYNPVITWTVPVAFFFLVVLAGIVFNIGRKSNLI
                     VFILAMLLPVTTVFIFMLLGGKIDMC"
                     /name="hypothetical protein"
     gene            complement(12380..12907)
                     /locus_tag="PIC49_RS25590"
                     /old_locus_tag="PIC49_25595"
     CDS             complement(12380..12907)
                     /locus_tag="PIC49_RS25590"
                     /old_locus_tag="PIC49_25595"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001473365.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF2726 domain-containing protein"
                     /protein_id="WP_000577045.1"
                     /translation="MIFNRNKKRDEQQNFSVVLPSAENVFSDFIKNNPALTTNAFTAIG
                     EVGCFTKVPLLSNKESEFLGILSRNIIPDYSVFPKIRLIEFVRPHGSEDAVKDLIREVQ
                     NITCDFVLKSYDETVLAVIQFGETATVRQQKKKLIIQRVCAMTGISFFEFKNTVDMMGS
                     EDFCQFLRDDEE"
                     /name="DUF2726 domain-containing protein"
     gene            complement(13043..13447)
                     /locus_tag="PIC49_RS25595"
                     /old_locus_tag="PIC49_25600"
     CDS             complement(13043..13447)
                     /locus_tag="PIC49_RS25595"
                     /old_locus_tag="PIC49_25600"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012421203.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001541973.1"
                     /translation="MKDNIVDFQRIRRDLGAHSTDVANDAVYSDKKKTSRFFYLLTPVR
                     YLLAASLYLVVVIPLGILAGFRFLLQFLGGIAVMGLTIAWYMGADVSGYVVLAAWIALT
                     VCGCAEQIFEWWIESRFAFRLFGIGRTPEE"
                     /name="hypothetical protein"
     gene            complement(13513..14520)
                     /locus_tag="PIC49_RS25600"
                     /old_locus_tag="PIC49_25605"
     CDS             complement(13513..14520)
                     /locus_tag="PIC49_RS25600"
                     /old_locus_tag="PIC49_25605"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000243325.1"
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006270 - DNA replication initiation
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /protein_id="WP_000243324.1"
                     /translation="MVLKNNKNSDCNDVQSLLAQGNQLLEGAYDITLIEMRLLYLALTK
                     IDSRKPQPANEYTLFAKEYRDTFSLDSKNCYEQLKSAASSLGSKPIVTYEWNEAKKRID
                     AVKRFWFSSIRYGVGNSESDITLRFSDSVSQYLYELKSEFTQMNLEHMVKLDTPFSFRL
                     YSWLYKYKNLNRNKKHSGVISTDPITIEWMKERTGLTGKYPVYKDFKKRVLDPAVDIIN
                     ANTNLSVTYEGIKSGRKIESVVFTYLVENETHDGKKIATKPLRPRLPSRPRVIKGSSAE
                     VAWAKKCIDVMKNYLISLREYDDKLKLSRPDLQKVKLWHEITGWDFEESFWFSD"
                     /name="replication initiation protein"
     gene            16063..16392
                     /locus_tag="PIC49_RS25605"
                     /old_locus_tag="PIC49_25610"
     CDS             16063..16392
                     /locus_tag="PIC49_RS25605"
                     /old_locus_tag="PIC49_25610"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001647051.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_001541974.1"
                     /translation="MFSVVYHPEAREEATALPLKIRVKFDRLIGKLEYDARLLREPDTK
                     PLGDGLFEIRTMGTDIARGIWVYHKGNTIIMLRVFIKKSQKTPVKEIDLARKRLAEVLN
                     ETGKP"
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            16373..16654
                     /locus_tag="PIC49_RS25610"
                     /old_locus_tag="PIC49_25615"
     CDS             16373..16654
                     /locus_tag="PIC49_RS25610"
                     /old_locus_tag="PIC49_25615"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019077272.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_000780222.1"
                     /translation="MKLVSHKELHNEWMQDDEYRAAWQEEERKEKLRELLAEWRKHDNL
                     TKAQVAERMGVTPPVISRLENNITKASIDTLTRYAHACGIKKPVIALY"
                     /name="helix-turn-helix transcriptional regulator"
     gene            16669..16995
                     /locus_tag="PIC49_RS25615"
                     /old_locus_tag="PIC49_25620"
     CDS             16669..16995
                     /locus_tag="PIC49_RS25615"
                     /old_locus_tag="PIC49_25620"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001541975.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein"
                     /protein_id="WP_129914608.1"
                     /translation="MSKTDYPASVDHNAAMIEELRADPDYANAYLANALEEINEPGGLG
                     GFLVALRQVIEARGGISEAVRKSGLARQSIYRALSPNGNPTITTLAQLTSVAGLQFTLS
                     KSSH"
                     /name="DNA-binding protein"
     gene            17632..18147
                     /locus_tag="PIC49_RS25620"
                     /old_locus_tag="PIC49_25625"
     CDS             17632..18147
                     /locus_tag="PIC49_RS25620"
                     /old_locus_tag="PIC49_25625"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001025391.1"
                     /GO_process="GO:0006457 - protein folding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="J domain-containing protein"
                     /protein_id="WP_129914607.1"
                     /translation="MNIQEALNVFGLSGELTEKDIKAAYRKAALKYHPDRNPLGAELMK
                     AVNAAFDFLMANIDKINQFQSTDEHARYHYGDDLERVLNVLSGLSGLVFEVIGNWVWIS
                     GETITHKETLKEIGCKWAAKKKQWFYRPEEHKSYWNREEHTIEEIRAKYGTTGQRRATG
                     WQRVETRA"
                     /name="J domain-containing protein"
     gene            18253..18795
                     /locus_tag="PIC49_RS25625"
                     /old_locus_tag="PIC49_25630"
     CDS             18253..18795
                     /locus_tag="PIC49_RS25625"
                     /old_locus_tag="PIC49_25630"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001401654.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_129914606.1"
                     /translation="MNSFFEQYHPVFEVVCRILGNGWRVNKLDDCSSRIKLTSPQFKNY
                     SVHIRMEKERFSVVGSVDSRSWRSPHHVCTLSRKRNPVDIAADIERKILVNASQEVLQA
                     IEYEKNQVAKKDEILILKGMLSQLVQLESWYGALTGFKAENGLNGKVTEQGDRYDLQIR
                     GLSIDQLVKITGYLKQL"
                     /name="hypothetical protein"
     gene            18792..19046
                     /locus_tag="PIC49_RS25630"
                     /old_locus_tag="PIC49_25635"
     CDS             18792..19046
                     /locus_tag="PIC49_RS25630"
                     /old_locus_tag="PIC49_25635"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001230709.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_129914605.1"
                     /translation="MRKNKGRLTYYLEVIDKKYHFVKKISSYSKEFTEGKTKTTKITLS
                     ELVFNDNEVEAIDFTKNGLRPVDKNVLLTMMKEYKESDA"
                     /name="hypothetical protein"
     gene            19043..19273
                     /locus_tag="PIC49_RS25635"
                     /old_locus_tag="PIC49_25640"
     CDS             19043..19273
                     /locus_tag="PIC49_RS25635"
                     /old_locus_tag="PIC49_25640"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001132407.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="XRE family transcriptional regulator"
                     /protein_id="WP_129914604.1"
                     /translation="MTIENTPENIKKLRKKIGLTQTECGEIFGVGLSTWQKKEAKTHNQ
                     LNLSKGEFEYLLLLAGEHPEYVLCKRRKNDL"
                     /name="XRE family transcriptional regulator"
     gene            19875..20147
                     /locus_tag="PIC49_RS25640"
                     /old_locus_tag="PIC49_25645"
     CDS             19875..20147
                     /locus_tag="PIC49_RS25640"
                     /old_locus_tag="PIC49_25645"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001272119.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_106668253.1"
                     /translation="MSAFAFRTTFKPTGDQQKDAITHIEVMQERAVKAFVSWMSSQEGT
                     EFLSTLQEITTELDSLIYAVESHTPVFRKKASELETLLAHYKTLL"
                     /name="hypothetical protein"
     gene            20220..20519
                     /locus_tag="PIC49_RS25645"
                     /old_locus_tag="PIC49_25650"
     CDS             20220..20519
                     /locus_tag="PIC49_RS25645"
                     /old_locus_tag="PIC49_25650"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001615573.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_129914603.1"
                     /translation="MTRLPFIESTTQQIFIFNTVTLCTIGLIHIETGKEYVVVFTDNNK
                     IRDYKTGIVPQFGEMKPSDIDLILFYRAEYEKYFDSLKIGDEALNINEYIKCMQ"
                     /name="hypothetical protein"
     gene            20831..21079
                     /locus_tag="PIC49_RS25650"
                     /old_locus_tag="PIC49_25655"
     CDS             20831..21079
                     /locus_tag="PIC49_RS25650"
                     /old_locus_tag="PIC49_25655"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005653200.1"
                     /GO_function="GO:0003729 - mRNA binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system HicA family toxin"
                     /protein_id="WP_000520549.1"
                     /translation="MGKTDKLLAKFLNSKKTFEWDELVVLFSSLGYVKKEMQGSRVRFF
                     NAEINHTILMHRPHPESYIKGGTLKAIKQNLKEAGLL"
                     /name="type II toxin-antitoxin system HicA family toxin"
     gene            21076..21423
                     /locus_tag="PIC49_RS25655"
                     /old_locus_tag="PIC49_25660"
     CDS             21076..21423
                     /locus_tag="PIC49_RS25655"
                     /old_locus_tag="PIC49_25660"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000681609.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system HicB family
                     antitoxin"
                     /protein_id="WP_000681613.1"
                     /translation="MKHLKYKGYLGTVEPDFENNVLYGKLAFIRDLVTYEASTLAELEQ
                     EFKTSVDLYLQSCVEDGKEPDTPFKGVFNVRLDPELHRRVAEMAMEEDLSLNAFVNKAL
                     EKEVSNHRAGA"
                     /name="type II toxin-antitoxin system HicB family
                     antitoxin"
     gene            21787..22290
                     /gene="ddp1"
                     /locus_tag="PIC49_RS25660"
                     /old_locus_tag="PIC49_25665"
     CDS             21787..22290
                     /gene="ddp1"
                     /locus_tag="PIC49_RS25660"
                     /old_locus_tag="PIC49_25665"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000781813.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA distortion polypeptide 1"
                     /protein_id="WP_000781817.1"
                     /translation="MKMIAFRLSDDELKLAEHNAISSGFTSINTFARHNVLNVDVQPSN
                     IPVSNESSKAVKTCLYPHEIELVKRNAALHGMSMSREIAIRVRQSLLKNEVCLYPDEVK
                     ELKKLSTAVDRVGRNIHFIIKGERFCTVNDPDFRKDVIEVIELCKQIDSKLETLTKSVV
                     NRFG"
                     /name="ddp1"
     gene            22294..23523
                     /gene="taxC"
                     /locus_tag="PIC49_RS25665"
                     /old_locus_tag="PIC49_25670"
     CDS             22294..23523
                     /gene="taxC"
                     /locus_tag="PIC49_RS25665"
                     /old_locus_tag="PIC49_25670"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001329504.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA relaxase/nickase TaxC"
                     /protein_id="WP_001329504.1"
                     /translation="MGVYVEQEYRIKRAKGTGRDPKSPKLSGRHIHASKSAFNHKVRHG
                     ADKKAYTWTPTKEVTFKITGSGKTAAGIKNGIDYITRNGELEAYCYDGKGSEQTGKGED
                     FNREFTSTLSKGNDYSRTYRGENIDHVKNMVFSPPPEAGVSREDALKATVEFLKETYPN
                     HAFVAVYHDDKEDHPHVHVNIKLRDEETGRRLRLTKSETRKFRNGFHRKLKGMGYDVTA
                     TWKKDPERKREIERLQAENPKRLRNVYKVVDFGETSYQNKAGEKRTPFLTYETLKGGKQ
                     VTIWGKDLKNHFESEKLQPGTLIKVKKLAPTLVRSPMFNDDGTVAGYRETHRNNWQIEN
                     IALERNRERQVHERETRQPEESDVKKQLSRKHEQGHNIGFALEHGFTKDSEEHKKLRIQ
                     QERNWKGLGF"
                     /name="taxC"
     gene            23600..23866
                     /locus_tag="PIC49_RS25670"
                     /old_locus_tag="PIC49_25675"
     CDS             23600..23866
                     /locus_tag="PIC49_RS25670"
                     /old_locus_tag="PIC49_25675"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000134734.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000134734.1"
                     /translation="MTEHDAIRISQLHQIFPEVQLTERQKDIAVMYVIGCTVEEIASEK
                     GITTDGVMYHLNLVKRAVGSATLAGVRTIAFLRMMAIVLTRES"
                     /name="hypothetical protein"
     gene            23871..24104
                     /locus_tag="PIC49_RS25675"
                     /old_locus_tag="PIC49_25680"
     CDS             23871..24104
                     /locus_tag="PIC49_RS25675"
                     /old_locus_tag="PIC49_25680"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000121161.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="EexN family lipoprotein"
                     /protein_id="WP_000120384.1"
                     /translation="MSYIKKVKILSLVLFSIALSGCGEEIKTVDWWRNHPEEAISKVEE
                     CKKSGDASDNCKNAKTALYKNQQQDAPVPQIN"
                     /name="EexN family lipoprotein"
     gene            24464..25084
                     /locus_tag="PIC49_RS25680"
                     /old_locus_tag="PIC49_25685"
     CDS             24464..25084
                     /locus_tag="PIC49_RS25680"
                     /old_locus_tag="PIC49_25685"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012908959.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lytic transglycosylase domain-containing protein"
                     /protein_id="WP_000157548.1"
                     /translation="MASLFPALLLCAASVHPDTINDIARVESGFNPYAVAEIIPERERG
                     SYGKSVISHMPKSKEEALTVIREIENRKRRYSVGLMQITSSNFSFYSTSAEKLLDPCEN
                     LSVFEKIIVDCYKRGRSLENALSCYYTGNFSNGKRKEKEFNNTSYVERIGYTGNEKKYV
                     VPGTRSNGGEQRKNRSHNASVIWPETILKSAFVDNSHPTKVIN"
                     /name="lytic transglycosylase domain-containing protein"
     gene            25098..25424
                     /locus_tag="PIC49_RS25685"
                     /old_locus_tag="PIC49_25690"
     CDS             25098..25424
                     /locus_tag="PIC49_RS25685"
                     /old_locus_tag="PIC49_25690"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000008644.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TrbC/VirB2 family protein"
                     /protein_id="WP_000008645.1"
                     /translation="MSFKKSVCNRISSSVTAVMQRKNKVVMAVAGATVASPAFADGFSK
                     AETLLEKVKTGLGGLSLVTVTIACLWVGYKILFGGSTLRECAPIIIGAVVIASAAEVAS
                     MMVN"
                     /name="TrbC/VirB2 family protein"
     gene            25443..28190
                     /locus_tag="PIC49_RS25690"
                     /old_locus_tag="PIC49_25695"
     CDS             25443..28190
                     /locus_tag="PIC49_RS25690"
                     /old_locus_tag="PIC49_25695"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016231857.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VirB4 family type IV secretion/conjugal transfer
                     ATPase"
                     /protein_id="WP_000105982.1"
                     /translation="MSTLYKAMTRPAMYVGVPVVPLTVVAGALFLAGVYISKLIWLAIP
                     VAVFILRMITKQDDHIFNLYFLKLKMLGNSVCNRFFGARAFLSGQYEAVEIDEFVNAMK
                     LNERITTGKYIPYSSHVDKNIVKTKNGDYVATWQLMGINFESISVEMLETIDSQVATLV
                     RSFSGLPVSFYNHSCRASFYDAFTTKSGNKYADIISDCYYGSMKKNKFKGNTLYFTLIY
                     RPDGRVEKLEKRKKSIKEKKDDINIHVKRMNEMINTFSGALDKFTCKLLGMYEENGKVF
                     SSQLSFYNYLLTGKLQKIRVTDSPVYNVLGGVDVFFNHDTGQICRIDGNRFFRSIEIKD
                     FCSETASGVFDVLQYSDADYIITHSYTSMSKSEALSTIKRAEKQLKSTEDDAVTQLQEL
                     EKAKNDIVSGDISFGYYHFTLMVMADSIRELDESVSKITADFTDLGIIPALSTMSLPAA
                     YFAQLPAVFHLRPRLSPVSNVNFVELASFHNFYQGKRDKNCWTEAVAILKTPSKQAYYL
                     NLHNSVLFKDETGEKNLANTKVIGTAGSGKTMFLSYLACSLQKYNNPETFADSAKNKKL
                     TCVFLDKDRGAELCIRMLGGEYYTVKSGEPTGWNPFALEATKRNRIFVKQLMEILCTRN
                     GERLSTRERLLISESVDAVMDFPPGEMREYGITRMLEHLMQRDDRDEQENGIILRLSQW
                     ANGQAHGWVFDNAKDTFNIQHVNNFGIDGTEFLDDPMVCAPITFYLLYRITQLLDGRRL
                     VIFLDEFWKWLQDEAFSDFVYNKLKTIRKLNGLVIPATQSPDEILKNKISRAVVEVCST
                     SIYLANPDADYNDYVEGLKLTPEEFNIVKNLDPMSRQFLIKKSSLKKGDGKSFSALATL
                     DLSGLGGYLKILSASADNLEIFESIYHEGMEPDDWVPEYLERAI"
                     /name="VirB4 family type IV secretion/conjugal transfer
                     ATPase"
     gene            28202..28918
                     /locus_tag="PIC49_RS25695"
                     /old_locus_tag="PIC49_25700"
     CDS             28202..28918
                     /locus_tag="PIC49_RS25695"
                     /old_locus_tag="PIC49_25700"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001401674.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type IV secretion system protein"
                     /protein_id="WP_129914601.1"
                     /translation="MKRIKTFLLISLLTASFYSSAGIPVAVDASPEWAVEAARWTERLK
                     QWSETAQHYQSQIQAYKDQLATATGIRNITAFTNELSNLQSELTNIYKQGNSYISDFTS
                     NPEGALSSQAKNLFSKYGAFDMCNTGYERNDNLCKARIVSTAASIEQGNEINKQLSSAM
                     SQIQSLSTRIEASKDMKESQDLANALQAQSLKMQAIKMQYDVWNSKNQADTAMLKEQQR
                     AEYKQQQMNAPIPTIQ"
                     /name="type IV secretion system protein"
     gene            28929..30008
                     /locus_tag="PIC49_RS25700"
                     /old_locus_tag="PIC49_25705"
     CDS             28929..30008
                     /locus_tag="PIC49_RS25700"
                     /old_locus_tag="PIC49_25705"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000007790.1"
                     /GO_process="GO:0030255 - protein secretion by the type IV
                     secretion system [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type IV secretion system protein"
                     /protein_id="WP_000007790.1"
                     /translation="MSFFVKYNTTVMEAIDKVGATYQSQFTQDIMSLVTVSVTLYVLWK
                     GYQILASKTQTPMQDLVWDLSKFAIIIMFITNADGYLTAATNALQGMKDGLSGGVSAWQ
                     TLDNLWEKTQNLAEKVYQKDTDFIPLAGALGMTLVWAGSLILMTISAVVFLTADITMKF
                     LIITAPIFIFCLMFGFIRVMFNNWLQSLFSSILTVLFASLVIRIAMDFQGDILQQVSNA
                     TPNSNVMTVSAMGFLAGLLGALLVLIAKSFAVQLAGAGVEGAVQGAAMMGLGAAGMATG
                     KSLMLGGRAGLGFGLGMAGRTGMNSLSGKAGNLMGRGARTAAEWAGEKGYQALAPTGAL
                     GMKARRLASLEKARARNAA"
                     /name="type IV secretion system protein"
     gene            30505..31191
                     /locus_tag="PIC49_RS25705"
                     /old_locus_tag="PIC49_25710"
     CDS             30505..31191
                     /locus_tag="PIC49_RS25705"
                     /old_locus_tag="PIC49_25710"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001290765.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type IV secretion system protein"
                     /protein_id="WP_001290765.1"
                     /translation="MSEKIEKKIETAKSFERQLYAENERSKKNAWRVAVAASLLSLCLG
                     AAICVLVPLKEKELAIVAVGEKTGRTELITQVKQEKILQSEALGRYFVNTYITLREGYN
                     YPSLQYDYETVQLYSSNTVKDDYLRLYNSDMAPDKIYHNNGSYVAVEVISNIISDATAP
                     DKLASVRFKKTTRNFTTGQVSVSYWTARVTYRFEPEKSVKSSSRELNPLGFTVTSYQTD
                     REVRGE"
                     /name="type IV secretion system protein"
     gene            31188..32096
                     /gene="virB9"
                     /locus_tag="PIC49_RS25710"
                     /old_locus_tag="PIC49_25715"
     CDS             31188..32096
                     /gene="virB9"
                     /locus_tag="PIC49_RS25710"
                     /old_locus_tag="PIC49_25715"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001299943.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="P-type conjugative transfer protein VirB9"
                     /protein_id="WP_001329500.1"
                     /translation="MMKKLFIATCLLLPGLVYSAATPLPSGFDARMQTVSYNGANTTVI
                     RSKTGFLTSVVFDEGEAVISAKAGFPAGWEITTDDNVVYINPRPVVQEQEGDEGEKLKK
                     VFQPTEKEWDTNLFVRTTKRIYSLDLILLSEEKQAQPAYVVQFRYPSEIAKKNAEEVRL
                     AKEKQEKLRQKKLISESFEKADAPKNWNYFMRVNEKYDSRRIAPDFAYDNGIFTFLGFN
                     SGKVFPAPFAVRDGQEQTLAFNVETKGKYKIMVIHNVNDKFVLRYGNSVVGVVNKSFGK
                     VLTDQRNTSSPAVERVEVNND"
                     /name="virB9"
     gene            32089..33207
                     /gene="virB10"
                     /locus_tag="PIC49_RS25715"
                     /old_locus_tag="PIC49_25720"
     CDS             32089..33207
                     /gene="virB10"
                     /locus_tag="PIC49_RS25715"
                     /old_locus_tag="PIC49_25720"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016231855.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VirB10/TraB/TrbI family type IV secretion system
                     protein"
                     /protein_id="WP_000131271.1"
                     /translation="MTDMKKTDDLVDDANQSKLESKPVHDIGDIRNKNNRMRSGFLFGL
                     MAVLVIGIFALKTYKNYFADDQQKASESTGDTSISQVSKIRTGLGQNFDPVENKAIINP
                     GATGSGNTVSDGHKEVPQEGFRKYLSIPVAGQGGSQTGASGSSRTSQTSEPQEERKESK
                     ENVPGKSGMKVTAINLDPDLYIEENRLIPCALTTRFVSDVAGRISCVFTEDVWSANHHT
                     KLLEQGTKAFGRYQTGTLNHGQGRMFVMWEQLRTPDNKRIDMVNTAAAGPLGEAGIDGW
                     IDSHFWERFGGSLMLSMVQDVAAAAADNAPGKDRNVDYTENSRQAMAEMAKVALENSIN
                     IPPTMYKNQGDIITIMVGEDIDFSDIYELKVK"
                     /name="virB10"
     gene            33209..34237
                     /gene="virB11"
                     /locus_tag="PIC49_RS25720"
                     /old_locus_tag="PIC49_25725"
     CDS             33209..34237
                     /gene="virB11"
                     /locus_tag="PIC49_RS25720"
                     /old_locus_tag="PIC49_25725"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001401678.1"
                     /GO_component="GO:0043684 - type IV secretion system
                     complex [Evidence IEA]"
                     /GO_process="GO:0044097 - secretion by the type IV
                     secretion system [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="P-type DNA transfer ATPase VirB11"
                     /protein_id="WP_000017225.1"
                     /translation="MSGVIPVSISNKSLDFYKNQVFQSFLDIEGLTEIAVNRPGEIWTE
                     INGDWTFHNNDSVTFDFCKRFSHTLASFRGDEIGDTKPLLSATLESGERVQVVFPPACE
                     RNTISITIRKPSTRQITHKEYVANGFYDYVQSGKKHRTYDDELLDLFRARNIAAFMELA
                     VAAGKTIVFAGATGSGKTTYMKSLIDFIPLNTRLITIEDAEEIKFFIHKNYVHLFYPSE
                     SGSDSGSIITAAKLIKSCLRMKPDRILLAEIKGGDAWDFVKVAGSGHSGSMTSIHAASA
                     KDAIIQMVTKCYQNRECQNLPFDVLRKIIMDSIDIVVHVGRDGVVRHMSDIYYKGAECE
                     NF"
                     /name="virB11"
     gene            34224..36086
                     /gene="taxB"
                     /locus_tag="PIC49_RS25725"
                     /old_locus_tag="PIC49_25730"
     CDS             34224..36086
                     /gene="taxB"
                     /locus_tag="PIC49_RS25725"
                     /old_locus_tag="PIC49_25730"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000847106.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="relaxosome-coupling protein TaxB"
                     /protein_id="WP_000847106.1"
                     /translation="MKTFNKSQSVFIFAVMLVAAWFAGSFIFFVLYFSQIKNLKPLKAV
                     FRSIDAYRMDIFTDSLTLSVVTTDIRVLAFVALGAGFVVSLIIPVAALIKLNEKKENIF
                     GDARFATINDIRESNSFTLDGDEKDGIIVGIKDKKIIRYVGAAFSAMGAGTRAGKGAGI
                     VITNLMKYWWSVIILDPKRECFNITSLIRKVILGHEVYKFDPFSPVTHRFNPLYYVSMG
                     TSEGFNQLENLSLIIYPYKTDGADAGSYLNKTAGGVFKSYAVALWFMIKNDKAGLKTLD
                     IEPVFSMSKINQLFERAEPEHLLSFMNDIRSELRGKDKTLADIGVAGLKAFIEMEDKTK
                     AQLKSNFLNGLSPFANPNVANATDGNDFDLRQVRKKRMTIYFCISGDNARLAEKITNIF
                     FQLAIQVNLEKMPTDDPEIKHDCLFLLDEFPSIGAVDYIKSKSGLIAGYKLKLLIVYQV
                     GSQLEEIYSYAGSKTLLASAPCKIVYSASDVKDARELSEAMGTRTVTIGSKSKSRSRGG
                     TSRSESESLIERPLVTTNELLTLKFSEEILAMKGENPIRCEKAFYYLNEYFFGDFVKVA
                     PELANIFPRKKGKLVMPPQKVFENEIVAKGYLVVKDVPDLDKAA"
                     /name="taxB"
     gene            36095..36517
                     /locus_tag="PIC49_RS25730"
                     /old_locus_tag="PIC49_25735"
     CDS             36095..36517
                     /locus_tag="PIC49_RS25730"
                     /old_locus_tag="PIC49_25735"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001353737.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cag pathogenicity island Cag12 family protein"
                     /protein_id="WP_015059903.1"
                     /translation="MMKKLVFLLISILAGCSSPPEPTPVQFEKANEVINPSLPYVPDFH
                     GVIKSDVSGKGWVYEITSLSGVQARTPTFYYALAHADRIVVTTHDAGLWFRIRDLLKME
                     GATAVVEWRNEKSFLPEQVKIVFIKAQNEVKNDWKK"
                     /name="cag pathogenicity island Cag12 family protein"
     gene            36501..36806
                     /locus_tag="PIC49_RS25735"
                     /old_locus_tag="PIC49_25740"
     CDS             36501..36806
                     /locus_tag="PIC49_RS25735"
                     /old_locus_tag="PIC49_25740"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000147044.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TrbM/KikA/MpfK family conjugal transfer protein"
                     /protein_id="WP_000147044.1"
                     /translation="MTGKNRVVLPALLALGLISTNANASDPCASVLCLYGKAVGQGGGS
                     ECRSAEKDFFNILKKKKGSIRWSKTFDARKAFLNQCSTADPAAISKIMSKFGKVKG"
                     /name="TrbM/KikA/MpfK family conjugal transfer protein"
     gene            36812..37066
                     /locus_tag="PIC49_RS25740"
                     /old_locus_tag="PIC49_25745"
     CDS             36812..37066
                     /locus_tag="PIC49_RS25740"
                     /old_locus_tag="PIC49_25745"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000415096.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000415096.1"
                     /translation="MEKQTTDLLNVIKTGHSGSIAGNPAHALDDKTMNAIIHNYVATIV
                     LGKAGNCKETPLTKYCSRTMPERISVEEINEFKIYPELF"
                     /name="hypothetical protein"
     gene            37169..37477
                     /locus_tag="PIC49_RS25745"
                     /old_locus_tag="PIC49_25750"
     CDS             37169..37477
                     /locus_tag="PIC49_RS25745"
                     /old_locus_tag="PIC49_25750"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000647576.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000647576.1"
                     /translation="MKARSVRVAGIEIIDSVKTVAFVFTETLLFMVWFSAIVYGLYRVV
                     IVLWDDPLKPQSLMEFLNFIVELYSYVLPSLAVIAVALIAVLSICKILSAIWEGRKQ"
                     /name="hypothetical protein"
     gene            37474..37968
                     /locus_tag="PIC49_RS25750"
                     /old_locus_tag="PIC49_25755"
     CDS             37474..37968
                     /locus_tag="PIC49_RS25750"
                     /old_locus_tag="PIC49_25755"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001215543.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="thermonuclease family protein"
                     /protein_id="WP_001215682.1"
                     /translation="MRHFLKALSFVVSLLPATLCAAEIQGKVIRVLDGDTIEVKTLPAK
                     IVVYEVPIRVRLINIDAPEKKQPFGRWSTNQLKTLLAGQSVTVSYTQTDRYGRIIGRVF
                     TTNGTDASRFMVQSGAAWVYERYNEDESLPALQREAQEQKRGLWADANPVPPWEWRYKH
                     N"
                     /name="thermonuclease family protein"
     gene            37984..38388
                     /locus_tag="PIC49_RS25755"
                     /old_locus_tag="PIC49_25760"
     CDS             37984..38388
                     /locus_tag="PIC49_RS25755"
                     /old_locus_tag="PIC49_25760"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001576899.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_021548625.1"
                     /translation="MALSPKEKKELQQRFEKQLLPDLDLSFELNGEVYKFNFDKNESGD
                     YIDSFTQAVWGGYQDAEEWEKYGKHQEIELPECPGPVEGWCDCDKCKSMFFHKEKNIYV
                     CLSCHKQTEPFLPIDWNSNDYDWLPYEDEY"
                     /name="hypothetical protein"
     gene            38448..38771
                     /locus_tag="PIC49_RS25760"
                     /old_locus_tag="PIC49_25765"
     CDS             38448..38771
                     /locus_tag="PIC49_RS25760"
                     /old_locus_tag="PIC49_25765"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001020836.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_106668249.1"
                     /translation="MNIHLFSEVLFCVWVIALIVILFIVVKYYRRVHYRLNSLSETIKR
                     TQGGVNKRISENRELLELIKNQHPEILDEYPWVSGWLDSQEKFLVALADKSGIDIYRMK
                     VKE"
                     /name="hypothetical protein"
     gene            38776..39015
                     /locus_tag="PIC49_RS25765"
                     /old_locus_tag="PIC49_25770"
     CDS             38776..39015
                     /locus_tag="PIC49_RS25765"
                     /old_locus_tag="PIC49_25770"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020315430.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_241389068.1"
                     /translation="MLGLPYPAGHWMYSLYDLLDNSVFVVCFFAFWVATGQFLLRTVHR
                     KFNISETVEMAIIALLGILMTLSFYLCAILKASL"
                     /name="hypothetical protein"
     gene            <39126..39386
                     /locus_tag="PIC49_RS25770"
                     /old_locus_tag="PIC49_25775"
                     /pseudo=""
     CDS             <39126..39386
                     /locus_tag="PIC49_RS25770"
                     /old_locus_tag="PIC49_25775"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012908955.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="DNA topoisomerase III"
                     /name="DNA topoisomerase III"
     gene            39391..41544
                     /locus_tag="PIC49_RS25775"
                     /old_locus_tag="PIC49_25780"
     CDS             39391..41544
                     /locus_tag="PIC49_RS25775"
                     /old_locus_tag="PIC49_25780"
                     /EC_number="5.6.2.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016247728.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003916 - DNA topoisomerase activity [Evidence IEA]"
                     /GO_process="GO:0006265 - DNA topological change [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type IA DNA topoisomerase"
                     /protein_id="WP_106668250.1"
                     /translation="MRLFIAEKPAVANDIVKALGGNFTRHDGWFESDNAIVTNCFGHII
                     QSQPPENYNPEYKAWKVETLPLRLYPVKYQPVESAAKQVKTILELIRRGDVTEIVHAGD
                     PDDEGQLLVDEVLEYAGNTKPVKRVLINDNTLPAVKKALANLKDNRDFKGLYLKALARS
                     VADAVYGFSMTRAYTIPAKARGYQGVLSVGRVQTPVLGLIVNRTRANQNHKSSFYYTMT
                     GVFQRGADVLRANWKPGEFAPLTDRKLLDKAWANETAASLAGKPATVEAAATDDKKTAA
                     PLPFNLVRLQQYMNKKFKMTAQKTLDVTQQLREKYKAITYNRSDCSYLSDEQFSEAPQV
                     IDALKSVFPQSLDIDSARKSKAFNSAKVTAHTAIIPTASVPDVNALSTDERNVYLAIAQ
                     HYLVQFMPEKAYQEVSVAIQCGDESFYARARKTTDSGFEAFLGAETTDEGESEDNDDSA
                     FELLCKIRTGETLTTKEVVVNEKKTTPPPLFTEASLLAALVRVADFVTDPTIKKLLKDK
                     DKDKKDEHGGIGTPATRAAILETLKKRNYITLEKGKLIPTDTGCALIDTLPGIAVNPDM
                     TALWSEKQTAIENGELTVEQFINELYSELTGMISDVDLGEMKIEPAAPAGQSQRLNAPC
                     PSCGKQIAIRPKGYFCTGCEFKIWSEFSGKKITQAQAEKLVKSGKTDLIKGFKKKSGGT
                     YDTVLVLEDKKTGKLGFPARTKK"
                     /name="type IA DNA topoisomerase"
     gene            41541..41747
                     /gene="hha"
                     /locus_tag="PIC49_RS25780"
                     /old_locus_tag="PIC49_25785"
     CDS             41541..41747
                     /gene="hha"
                     /locus_tag="PIC49_RS25780"
                     /old_locus_tag="PIC49_25785"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000850858.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hemolysin expression modulator Hha"
                     /protein_id="WP_000850859.1"
                     /translation="MKTKQEWLFQLRKCTSRDTLEKVIEINRYKLPLSESEAFYSAADH
                     RRAELVMNKLYDKVPSGVWKYVH"
                     /name="hha"
     gene            41763..42227
                     /locus_tag="PIC49_RS25785"
                     /old_locus_tag="PIC49_25790"
     CDS             41763..42227
                     /locus_tag="PIC49_RS25785"
                     /old_locus_tag="PIC49_25790"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001293133.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0030527 - structural constituent of chromatin [Evidence
                     IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="H-NS family nucleoid-associated regulatory
                     protein"
                     /protein_id="WP_001419802.1"
                     /translation="MSELTKEDEYGIISRTMMNIRSLRVFAREVDFEQLLEMQEKLNVV
                     IEERREDAEREAAERQELEAKRQQAIEYIISLGLDPESLLAPVTADTVKTRRKAKGGVR
                     KAKYRFKDENGEIREWSGNGKRPLALQKLLDEGHFMEDFLIDKLQPGQVE"
                     /name="H-NS family nucleoid-associated regulatory protein"
     ARG             10127..10998
                     /name="blaCTX-M-24"
                     /gene="blaCTX-M-24"
                     /gene_name="extended-spectrum class A beta-lactamase
                     CTX-M-24"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     Typing          complement(13514..14520)
                     /name="IncX4"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.702"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          22295..23520
                     /name="MOBP"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="99.511"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          28930..29981
                     /name="MPF_T"
                     /typing="mate-pair-formation"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="98.0"
                     /evalue="2.79e-168"
     Typing          30506..31188
                     /name="MPF_T"
                     /typing="mate-pair-formation"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="1.45e-137"
     Typing          31189..32093
                     /name="MPF_T"
                     /typing="mate-pair-formation"
                     /tool="MOB-suite"
                     /identity="99.669"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          34225..36083
                     /name="MPF_T"
                     /typing="mate-pair-formation"
                     /tool="MOB-suite"
                     /identity="98.871"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 tggttgatga cgttattggt tttactaaga cgggtaaaaa agtgcctggt cgtgaatatg
       61 ctctgacgga tgaggggaaa aaatatctga agtctccgga acgacctgat ttttgcgtcg
      121 gtcattataa ggtggatgag atagttgatt ttaccgaacc tggtgatgct atgggaatga
      181 agatcacgca ggtgaattac acattcagtc ccaccagtat cgctgaatgg gcgaaacgcg
      241 atgatgttcg ggctgcattt ttaggacttg agtctgattt gaaagagaaa caaacaaaac
      301 gtattacact ggttttgaaa aatgatggat ggtctgctga acggtaggct gtaatggtgt
      361 tgctacgtga aaaatacccc acgtatatcc cctacttttt cacggatttc acgtagcgca
      421 ccgccgttaa tgactctatc aaaaatactc accgatattt ttcgcactgc aaacaaccta
      481 actcactgta aaacaacaaa tcagctttgc gccggtgacg catcgatcgc gctggccagc
      541 gcgatcctca gctgcgatcg ctacagtatt tttgaacaag attaccctcg ctccggttta
      601 attcgccagg cagttagaca tacaggtcat tctgtccagc gccagcaatt caccgccacc
      661 gggtgcgcgg acagctcgaa atctgctggc aaatcagaat ggcgccagtt gctgcagtgt
      721 aattatttgc tggcacaatc cggtatcgat gcggcgccac ggtcgcataa ctgctggtaa
      781 atccccctgt tacataatcc ccgcgccagc ctgaacattg cagtcattct tggcagtggg
      841 gaaatcagac cagagtcatg agtagattta ttatgttaga agtattatgc tgactgcaag
      901 attcttatat tataggattg caatgatgga taaaatatcg aatcttttta aatggatatt
      961 tagcttgaat cctgttgaag cggtggttaa cgatcctact cagaagctat taaatagcat
     1021 gcgggttacg tcaaaatgca ggtataacgc gtcgatacga ttaaaaagac aaagtcaatt
     1081 atcttttttt tcaacaacag tactatcttt ggggctgatt ttaattcctt tactccaaaa
     1141 tgccgatata catttacacc tcccattaaa agttttgaat atgcttcaga tattccttgc
     1201 tgtttctgtt ctggtttact ctgtgattat aggaactgca cattatgaaa ttaggtcaaa
     1261 acaacttaac gaatgtggtg ataagatcaa agatcttata agaaaattaa gattgggaaa
     1321 taacaaggaa gaattatcaa catatataca aatgtatgat tctgtcagta ctgaatcgga
     1381 aaaccatgct agagttgatt ttttgcttgc ttcgttagag atgaaaactg attataaata
     1441 caccggcctt cttcgatttt ggctctatat tcgttctatt tttctttaca tattcccgtg
     1501 gttaatacct ttgacactag tattgtcaga aataatattt atttgtgaca tgcttggagt
     1561 aacttatata tctactccgt tccttacagg agagtgaata gcgttttgct ctttgtagcc
     1621 atgccataag ttgctgagtc gtagaaggcg attcagccat aagccatttc aaatattcga
     1681 tgcgatccat atgtaactct caataagaac aattaattac gaacgtattg ggcttcctgt
     1741 cccgcgaatc acagtggtgt tcgtgatgct ccctgcggaa gcggaacttc gtagctacca
     1801 tgctcgcttt cgtatctacg gatgaagacc ttcacctgcc tgtctaatag ctcaaacagt
     1861 gagataagtt cggtgataag ccctgccaca taaccttcat caatgatgat acggtgtcga
     1921 attagcctaa tccctttttt ttgtttacag tagctttcta tatcagcaag ccgctccgcc
     1981 ctgtgtttct ctatctcacc ttcggagtga accagcacat gcctgatttg ttccactttc
     2041 agcatatcct cccagcgttt ccacaattcc ccgcccggat tcatatcaaa aatagcttct
     2101 cgtcgcagaa atttacgata ctctttaata catgcgttac tcaatgaata agattcactc
     2161 atattttttg gaagcagcat gtttatttcg gcgcacaacg ttttgatttg atgttcgaag
     2221 aagttataca gcgtgataac catcgcctta cggtgcatag ggggataaat atcaccaaat
     2281 tcctgcatct cctgatggta gctatcgata atatcctcgt ggtatttctt atcactttcc
     2341 tttattcgct gttcaatttc ttcacacagc cttttattac ttttcgcaat attattctca
     2401 gaatatttat tatatgtagc gtaattatgg agatctatag ttgtgaaatg acaaaggtga
     2461 aaaagggttg taccgaagaa atctataaca ttggggtaac gaaattcagt atccagttcc
     2521 atacacatcc ttaatcgcat gacagcctta agctgttgcc agtcgcatct ctaaagtaag
     2581 catttatcat aattccagca cagactggac gtacagcatt ttctgtccag tagacagact
     2641 gttacactca ggataggata gcttctatgg ttaaatttcc aggtgaagtt atgagttcgt
     2701 ccgctgctgt aaccgttata actggtgttc ttgtttttgt tggtggtcag ctcattgtaa
     2761 agagcgcgat tgaaccttat atagaattca agaaacaatt gggaaaaata tcaaatctgt
     2821 tattagctaa ccaagctaaa ttagctaatc cttgtgctgt tgaaatgtct gagatcatcc
     2881 atgagttgaa agatgccgca gctcagttaa tgtcgaagca ttcagcttta cctttctata
     2941 tcaaaaaatt tcatatcgga ttccgctttg ttccatcaac gcctgaaatt attagttcgg
     3001 cgcaaaaatt gaatttgata gcatcaatac atgaaggtaa aagcaaggaa agtacatatg
     3061 agcacatagc cgagattgga cgtatgctca aaatcccaac cacctattct ctttaatctt
     3121 cacgccgatc agattgcata atccacgcgc cacctggaca ttcaggtaat cttgtcaaaa
     3181 aaagccacac taatgggtgg cttcaagggt aaaataaaga caaagcggat tctatttcac
     3241 tgccagctaa tttcaataat aaatttgtta ttctcattag ccttcgatga gttaatccta
     3301 taaccagatt cccttagaac cttgaccact tgctcaagaa tgttttcatg gacaggataa
     3361 ataaaggatg tctggcccaa tcttgcttgg agctttattt ctccaaatat catatcaagt
     3421 gttttgtctg catcaggtat cactgaagaa ctaatctttt tagcttcact ggcgctgata
     3481 tgtttatttc ccataaataa tacctctttt ccttaatgac atcgcaacag aattaaaaga
     3541 aattatagaa gattatctgc attatagaaa ggttgacact ggttgtagta cgatcacaat
     3601 tccttgcaaa cttggacatt caggttattt cgtctggtta tactggatgc gcgggatctg
     3661 gcttggtatt atttaaccag ttaattcaac agcggtggtg tcttatgaac gtcaagaaca
     3721 tgttttacgg tgccattctg gtaagtgctg tatgggcggt tattttgctc tcatggtttg
     3781 aatccagcct taccttaagc gattacctcc ggtacgaatc ggtaatcctg atcccatgcc
     3841 tgctgtgggt tgctgtttat ggattaggta aacgttacct ccaaagaaca tcaaactagg
     3901 ccgcgtcagc ggcttttttt acgcccttcg tttaattccc tagtcacctg gacatacagg
     3961 tgattctgtt cagctatgct ggagattgta aagtcccata gaggaataaa aatcttgtgt
     4021 tagtcctaaa atgggactat tattcattac atgaagataa tcgctatcaa gacgcttagg
     4081 gatttttgga cggcgaatcc tgatgcagaa cagccgctaa aggcttgggt agatgaagcc
     4141 agtaaagctg agtggaaatc tccagcagaa attaaggagc aataccgcag cgccagtatt
     4201 cttaagaaca ggcgagtggt atttaacatt aaaggaaatg actatcggtt aattgttgct
     4261 attgcatacc agcgcgggtg gatgtttatt aaattcatcg gtacgcacaa agagtatgac
     4321 aaaatagatg ctgagacagt tagcctggag taaaccatat gcagattaaa ccaattaaaa
     4381 ctgaacagga ctatgaagcg gcactgcgtg ccgtagagcc tatgtttgat aatgagcctc
     4441 cagctgatac accggagggg gatttttttg aaattatgtg cgtactgatt aatgagtacg
     4501 agaaaaaaca ctatccaatt gaagctcctg atcctgttga agctattaaa ttcagaatgg
     4561 agcagcaggg tttaacagtg aaagatctgg agcctgcaat tggcaaatct aaccgtgtct
     4621 atgaagtgct taatcgtaaa cgcaacctga cccttccgat gattagaaaa ttacatacaa
     4681 tgtttggtat cccgttaaaa agtcttgtcg gagggtaatc atgatggaat atatagaggg
     4741 ggataaatga aaaaaaattt ttttaaaaac gacactgttt tccctgttaa caatttcttt
     4801 gtcgctttaa ctcttgtgtc ttctctgctt aactctgtcg gaatattttt tcccatgata
     4861 tctcattctg gtaatgttat tgagatgtgt tttttcgtga tgttttcagt attactggct
     4921 gcattcagtt ttgtaagtac aatggggctt gcgaacgcaa tagcacccat taaaaatgcg
     4981 tttccgcttt tattgttggt tattgtcttt attactaatt ataatattta cctccgataa
     5041 gtaacgaggt gtggcagcgg ccttttttac gcctctcgat taattccccg cgtcgcctgg
     5101 acagttaggt aatttcgttc acttccgctg gaagtgcggg agctgggtcc cgcacatacc
     5161 tctatccaga gttactaaat atgataatat cagtgataga cttgttatat tgaagtgtgt
     5221 tgtaaagcaa cacacttcaa tattttaatt gttattctgc atcaaccgct cttacgagta
     5281 gcttccacgt attgttcttg tgtgctttct tctcacagtt gctacatggt ggaagtttgt
     5341 tacattggcg attaattaaa tcttcataac cacatgcctg gcatctataa atgccagcat
     5401 gatcaggttt ttctcctggt ttccaaattt tttcgtattt tgcattagcc ttttcatttg
     5461 tatttttctt aacgttctta ctatctatat accatgccat acggttgctc cttaaaagtt
     5521 tattctgacg tagaatcatt aattagttta tttgccagtt ttttgacgta ataataaaga
     5581 tctgcccctg atctctgcga tgttatctaa atttatatct ctctcctcat aataaccagt
     5641 tcccttatct ttcacaactc tgattagctt cgcaagtgaa tcattatttt ttctattact
     5701 attcttgcac tcgaatcctc aaactgattt ctggttatat ctacatagtg ttcaccaatt
     5761 tgcaaaaaaa cgtgcgcatg gatactctgg ctatgttatc tcactgcgct actactgtct
     5821 tctctcaggg ggcgtatttg tctctggcct cgtttaaggg gtttgaagcc caatggagcg
     5881 gaaacgtacg ctaagaagct aactatatga ttttaagtca ataaagtcgt ggcgttgtta
     5941 ggcaggttta cgttgatttg attaccgagt ttattaacac tgaaagtccc tgaaaccgca
     6001 tggctactgg catcgacggg aagagtaaac aaaaccctcg ttttctttac tcacctcttc
     6061 tgctcaaaaa atgaacttag cgtacgatct cgtacggttg ggcctcaaac cccttttaat
     6121 tctctgtgta tctggacatt taggtgtttc tgtccagacc aaattagtta caacatacac
     6181 taaattcatt tcctttatct ggtgctctgc tccggcatac gcgcccatat cctggataat
     6241 tcaggataac ttccagattt cgtcctgccc tgccgttcat atccgcctgg acaaaaatgc
     6301 attatcggaa aaaatgtcca aaattttttt tggtgatcgg aatttttgtt gtcggacgca
     6361 cctctgcttc aggtcataat tgctgacaca tcccaaaaaa acaggtgcgg agatttaaaa
     6421 attgagtcac ttacccgcca acattttcca gatttcacgt agcgacgcct ggaatttaac
     6481 cctctctccc gatgcagccc gtaatatgcg ggatctggcg gcacagattg gcgcaggaat
     6541 gccaaaatat ctgatagcac cggaagtctc actgcttctc tcctacattg atgatctgag
     6601 catccgtatg tactttgaga cgctctggaa taccggagca cgactgaatg aagctctggc
     6661 gctgaaacct gctgatttta tgctgactcc gacgcgccag tacccgcaac ccgtggtgat
     6721 cctgaaaaca ctcaagcagc gtataaaaga agcagaaaga agaccaggac gcccgaccac
     6781 caggcatcca ccattgcatc ctgatccgcg atacagaaaa ccaccggagc ctgctgtaag
     6841 gctggttcct gttctggatg caggatacgc attgcgtatg cgggaatacc tggcgacctg
     6901 gaaaaagcgg atcaaacatc agcctgtgtg ggacataaca tcgagacaga caccgctgaa
     6961 ctggattaat accgcagtgg cacgggcaga acgtgacggc gtaacatttt cggttccggt
     7021 tacgcctcac acgtttcgcc acagttacgc catgcacctg acaatgagtg gcgttcctcc
     7081 gcgcgtcctg caatccctgc tgggacaccg ttatgcaaga agcaccgaga tttacacccg
     7141 cgttttttcg ctggacgtcc tgacaggaag tggcctgtcc tttacctgcg atccacagcg
     7201 tgcaaaacag cttctcggat accctgaacg cattaatgat gagtaataat acacaccaat
     7261 aaactattgc cagcacgcaa tagtacggtt atactttcac cacgaaagat tgtgtattaa
     7321 tacacactat ttaaccgaga gggttttgtg atgggaaaaa tcattacagt tgcagggcat
     7381 aaaggcggca taggcaaaag caccgtgctt tgttccttat gtgtctgtgc catcaggaaa
     7441 gggaaaacag cctgtttcct ggaaacagac tcgcagggaa gcatcaagga cttcatcgag
     7501 gagcgtaaaa ccaacgagcg gctgtctgaa ataccgtatt tcgagtgcta cacagatatt
     7561 ccggcgatgg cacgaaaact ggctgcccgc tttgattatg tgtttgttga tacgccagga
     7621 atgaaatctc cggccttcgt taaggcactg agttgtgctg acattctgtt cacattcatt
     7681 gagccaggag caggcatcga gatcaacacg ctgggacgac tggttttcga cattaaaaca
     7741 gcacaggccg gagtcaatcc gtcaatgaaa gcatggattg tcctgaataa gtgttcaact
     7801 aacccgtcag acagcgaagc gtcagaactg cgccgacaac tcaatgatga tcctgactgg
     7861 cttccggttc cccgccagcg tatctatatg cgtaccgcgc ataaaaaagc ctataacagc
     7921 ggtatgggcg tacatgaata cgatgataaa cggggaaaca aagcccgtgg agagattgaa
     7981 ttactgttaa aagaaacgga tgttctgtga tgtgtattat tacacactat aagaggtggt
     8041 atactcacat ctgaatagtg tgtataatta cacactttac taaaaacagg ataccgatct
     8101 aatggcaaag ctcccaaaga aaattgatca ggaaattaaa ccgctggatt tacgccagtt
     8161 tgtaagttct gctgcacaaa aaccagcatc ggcatccgca gtaacgcgta taaatctgac
     8221 tatgacagat gatgatctgg atacagcgca ggtgttccag aacaagtacg gagcaagccg
     8281 tgctgaagtt atcagagcag cactggcagc gttacgtctg gtatcagcag aagaacgtcg
     8341 gaggctgttt gatgatataa ggaaaaacag cccgaaagcc ggaagaccaa ccgtaaataa
     8401 atagtgtatt ttattacaca ctattaaaga ggataaaaat atgcttataa aaatcaccta
     8461 gattctacgt cagtacttca aaaagcataa tcaaagcctt gataaatatg cattccttcg
     8521 aaattcagct ttcacccatt gggtgaaaga aaagtgctca aaaatatgtt aaattatcag
     8581 cttttatgac tcgatatatg gtaaaataat agtaagaaaa gtagtaaaaa ggggttctaa
     8641 ttatgattaa taaaattgat ttcaaagcta agaatctaac atcaaatgca ggtctttttc
     8701 tgctccttga gaatgcaaaa agcaatggga tttttgattt tattgaaaat gacctcgtat
     8761 ttgataatga ctcaacaaat aaaatcaaga tgaatcatat aaagaccatg ctctgcggtc
     8821 acttcattgg cattgataag ttagaacgtc taaagctact tcaaaatgat cccctcgtca
     8881 acgagtttga tatttccgta aaagaacctg aaacagtgtc acggtttcta ggaaacttca
     8941 acttcaagac aacccaaatg tttagagaca ttaattttaa agtctttaaa aaactgctca
     9001 ctaaaagtaa attgacatcc attacgattg atattgatag tagtgtaatt aacgtagaag
     9061 gtcatcaaga aggtgcgtca aaaggatata atcctaagaa actgggaaac cgatgctaca
     9121 atatccaatt tgcattttgc gacgaattaa aagcatatgt taccggattt gtaagaagtg
     9181 gcaatactta cactgcaaac ggtgctgcgg aaatgatcaa agaaattgtt gctaacatca
     9241 aatcagacga tttagaaatt ttatttcgaa tggatagtgg ctactttgat gaaaaaatta
     9301 tcgaaacgat agaatctctt ggatgcaaat atttaattaa agccaaaagt tattctacac
     9361 tcacctcaca agcaacgaat tcatcaattg tattcgttaa aggagaagaa ggtagagaaa
     9421 ctacagaact gtatacaaaa ttagttaaat gggaaaaaga cagaagattt gtcgtatctc
     9481 gcgtactgaa accagaaaaa gaaagagcac aattatcact tttagaaggt tccgaatacg
     9541 actacttttt ctttgtaaca aatactacct tgctttctga aaaagtagtt atatactatg
     9601 aaaagcgtgg taatgctgaa aactatatca aagaagccaa atacgacatg gcggtgggtc
     9661 atctcttgct aaagtcattt tgggcgaatg aagccgtgtt tcaaatgatg atgctttcat
     9721 ataacctatt cttcagaata cagacagcaa ataaagacct ttcgtttgaa gtatgtattt
     9781 cttgcagcaa aaataatcaa aaccgcaaga tatgtaatca tgaagttgtc ggaaaactat
     9841 ccgtacaagg gagtgtatga aaaatgtctg gtataataag aatatcatca ataaaattga
     9901 gtgttgctct gtggataact tgcagagttt attaagtatc attgcagcaa agatgaaatc
     9961 aatgatttat caaaaatgat tgaaaggtgg ttgtaaataa tgttacaatg tgtgagaagc
    10021 agtctaaatt cttcgtgaaa tagtgatttt tgaagctaat aaaaaacaca cgtggaattt
    10081 agggaatact gatgtaacac ggattgaccg tattgggagt ttgagatggt gacaaagaga
    10141 gtgcaacgga tgatgttcgc ggcggcggcg tgcattccgc tgctgctggg cagcgcgccg
    10201 ctttatgcgc agacgagtgc ggtgcagcaa aagctggcgg cgctggagaa aagcagcgga
    10261 gggcggctgg gcgtcgcgct catcgatacc gcagataata cgcaggtgct ttatcgcggt
    10321 gatgaacgct ttccaatgtg cagtaccagt aaagttatgg cggccgcggc ggtgcttaag
    10381 cagagtgaaa cgcaaaagca gctgcttaat cagcctgtcg agatcaagcc tgccgatctg
    10441 gttaactaca atccgattgc cgaaaaacac gtcaacggca caatgacgct ggcagaactg
    10501 agcgcggccg cgttgcagta cagcgacaat accgccatga acaaattgat tgcccagctc
    10561 ggtggcccgg gaggcgtgac ggcttttgcc cgcgcgatcg gcgatgagac gtttcgtctg
    10621 gatcgcactg aacctacgct gaataccgcc attcccggcg acccgagaga caccaccacg
    10681 ccgcgggcga tggcgcagac gttgcgtcag cttacgctgg gtcatgcgct gggcgaaacc
    10741 cagcgggcgc agttggtgac gtggctcaaa ggcaatacga ccggcgcagc cagcattcgg
    10801 gccggcttac cgacgtcgtg gactgtgggt gataagaccg gcagcggcga ctacggcacc
    10861 accaatgata ttgcggtgat ctggccgcag ggtcgtgcgc cgctggttct ggtgacctat
    10921 tttacccagc cgcaacagaa cgcagagcgc cgccgcgatg tgctggcttc agcggcgaga
    10981 atcatcgccg aagggctgta actggttttg ttgaataaat cgaacttttg ctgagttgaa
    11041 ggatcagatc acgtatcttc ccgacaacgc agaccgttcc gtggcaaagc aaaagttcaa
    11101 aatcaccaac tggcccacct acaataaagc cctcatcaac cgtggctcca taactttctg
    11161 gctggatgat gaagctattc aggcctggta tgagtcagca acaccttctt cacgaggcag
    11221 acctcagcgc tattctgacc ttgccatcac gactgtgctg gtcattaaac gcgtattcag
    11281 gctgaccctg cgcgctgcgc agggctttat tgattccatt ttttctctga tgaacgttcc
    11341 gctacgctgc ccggattaca gctgtgtcag caggcgggca aagtcggtta atatcagttt
    11401 caaaacgccc acccggggtg aaatcgcaca cctggtaatt gattccaccg ggctgaaggt
    11461 cttcggtgaa ggcgagtgga aagtcaaaaa gcatggccag gaacgccgtc gtatatggcg
    11521 taagctgcat ctggcagttg acagtaaaac acatgaaatc atctgcgctg acctgtcgct
    11581 gaacaacgtt acggactcag aggccttccc cgggttaatc cggcaaaccc accggaaaat
    11641 caggtcagcc gccgccgatg gagcttacga tacccggctc tgtcacgatg aactgcggcg
    11701 taagaaaatc agcgcgctta tcccgccaat cattaaatat gtattcaatt tttacatgcc
    11761 tgtgtgcagc ctttacttgg attatttctc gtgggttaca gtatatggcg cttctcaggt
    11821 aaccagacat tagggcactt taggggattt tcaatctatg gaacactgca tctttgattt
    11881 aggcattata gactataatc ctgtcattac atggacagta cctgttgcat ttttcttttt
    11941 agtagtgctg gctggtatag tattcaatat tggcaggaaa agtaatctaa tcgttttcat
    12001 cctggcaatg ttgctcccag taacaacggt tttcattttt atgttactgg gcggtaagat
    12061 cgatatgtgc tgatcaatta aaagaggatt aaacaatgat aaattcaatc gcgtttagtc
    12121 ttatagcgtt atgtataata tatatatcat cactacttaa aaaaagtaac ttcagaatat
    12181 tttatataac tgtatctacg tgctctttat tattatcatg tgtaccaaac aagtacggta
    12241 tgattggtat agcagcattg gtatttacaa ctatgttagg accatcatta attattttag
    12301 aggataacag acaataaatt atgacaatgc gtttgttaag cccgcaaata tgtgggctta
    12361 tttttaattt ctaatatttt tactcttcat catcccgcag gaactgacaa aaatcttcgc
    12421 tccccatcat atcgacagtg tttttaaatt cgaaaaaaga aattcctgtc atagcacaca
    12481 cgcgctggat aatcagtttt ttcttttgct gtctgacggt tgcggtttca ccaaactgga
    12541 taacagccag gactgtttca tcatatgatt tcaggacaaa atcacaggtt atattctgca
    12601 cttcacggat taaatctttt acagcgtcct cgctaccatg aggacgaaca aattcaatga
    12661 gccgtatttt gggaaaaacg gaataatcag gtataatatt acgtgaaaga atgcctaaaa
    12721 actctgattc cttatttgag agtaagggta ctttagtaaa acaaccaacc tccccaatgg
    12781 ctgtaaaagc attggttgtc aaagctggat tgttcttaat aaaatcagag aatacatttt
    12841 cagctgatgg caaaacaaca gaaaaattct gttgttcatc tcgtttttta ttacggttaa
    12901 atatcatttc atattccttt taaaagagcc tgcggcaggc acaggcaaaa acatcgtttt
    12961 tggacaatca tggataaaat gttaacattt tgaccatgat tgtctatcct gcattgttct
    13021 ttactgtctg taagatcggc actcattctt ccggcgttct cccgatacca aaaagacgga
    13081 acgcaaaacg actttcgatc caccattcaa aaatctgctc tgcgcaacca caaacagtta
    13141 aggcgatcca tgcagcaaga acaacgtaac cactgacatc tgcgcccata taccaggcga
    13201 tagttaaacc catcactgcg ataccgccta aaaactgcaa caagaaacga aatcccgcaa
    13261 gaatccccaa tggaataaca acaaccagat aaagggaagc agccagaagg tatctgacag
    13321 gtgtcagcag ataaaagaac ctggatgttt tctttttgtc agaataaacg gcatcatttg
    13381 caacatctgt tgaatgagcg cccaggtctc tcctgatacg ttgaaaatcc acgatgttat
    13441 ctttcatatc atcctctctt ttaagtgagt tataaaaaga gaaaaaacgg gtaacgtaaa
    13501 cagcagcatt ctttaatcac taaaccagaa cgactcttcg aaatcccatc cggttatttc
    13561 atgccataac ttaaccttct gaagatctgg ccttgataat tttaacttat catcatattc
    13621 ccttaaagag ataagataat ttttcataac atcgatacat ttttttgccc aggctacctc
    13681 cgcagagctt cctttaataa ctcttggtct tgatggcaat cgagggcgta acggtttagt
    13741 tgctattttt tttccatcat gtgtttcatt ctctacaaga tatgtgaaca caacagactc
    13801 gatctttctg ccggacttga taccttcata ggtaacactc agattcgtat ttgcattgat
    13861 aatatcaaca gcaggatcaa gcacccgttt cttaaaatcc ttatatactg gatatttccc
    13921 tgtaagcccg gttcgctcct tcatccattc aatggttata ggatctgtcg agatcactcc
    13981 actatgtttc ttatttctgt tcagattctt atatttatac aaccatgaat aaagtcgaaa
    14041 tgaaaatggc gtatccagtt tcaccatatg ttcaagattc atttgtgtaa attcgctttt
    14101 cagttcataa agatattgac taaccgaatc tgaaaaacgc aaagttatgt cactttcact
    14161 attcccaaca ccatatctta ttgaagaaaa ccagaatcgt ttgactgcat cgatcctttt
    14221 ttttgcctcg ttccattcat acgtaacaat tggctttgag cctaaagaac tcgcagcaga
    14281 ttttaactgt tcataacaat ttttcgaatc taaagaaaaa gtgtccctgt attccttcgc
    14341 aaacaatgta tattcatttg caggctgtgg tttacggcta tcaatcttag tcaatgccag
    14401 atacagaaga cgcatttcaa ttagcgttat atcgtatgca ccttccagca attgatttcc
    14461 ctgtgccaac aaactttgaa catcattaca gtcgctattt ttattattct ttaagaccat
    14521 acagctcccc ttcccgtgag ttaaaaatca aaagaagttt ctcacaccca aactagggac
    14581 gcaatttttt tttgtcccta tataactaat aaaccataaa tctgtccccc gtttgaaggg
    14641 tcaaacctgg ctgaacggcg cattttcacc ctcagtcaga ggcagtcaat acagcaaacc
    14701 aggagggaat gcatcatcaa aaacccatag agccaaacat cttaaatgtg atctaagtca
    14761 ctaattaaat tcagattcat agagaatcca taacgaatcc gagttgaatc taaaaaaagt
    14821 tatccacaac ctgtggataa aaaagttatc cacactaaat ctgtccctag ttgaccataa
    14881 atctgtcccc ttttaaccat aaatctgtcc cctgataaaa acgcaaataa ccataaatct
    14941 gtcccctttt aaccataaat ctgtccctag ttagcattgc aatcaattga aaaacaaaag
    15001 aaaaaacacc cctgaaaaag gaaatattat atgtaacata ggagtgatct atcttttaga
    15061 aaaaagaaat tagaaaaaaa gaatagagcg cattgtgaat tttttgagtt ggaatcagca
    15121 aaatcacaag atgaggtcag accagagcgt acggattcat atgctgcatc gaagacattc
    15181 cgcttcctcg ctcactaact cgctccgctc ggtcgttcga ctgcggcgag cggagtcatt
    15241 tctcacatat cgctggtaat tctgttgttg ttccttcggt gatgagtcgc ttgatagcct
    15301 ataaaacacg ctcagaagct ctcagacgca cgaaacgggt ttaaataccc cttagggcat
    15361 gggaggcgcg aaaaacgctt acagaggctt tctattcatc agaatctgat cctgtgaaga
    15421 ccgagaaagt tctcatgttt agtcacaacc tgaatatttc attccgaggg cggtttaata
    15481 taactaactg attttattgg aatagttcgt ttaattatga tcctcatttt gctaaccgag
    15541 gatcttctca tgtttcaatt aaataccttt aatatcaaca tgatatgttc ttttgccaat
    15601 tgatttatgt gaccacatca tttcaacgat acataaatca acagattcag caatgccccc
    15661 tccccaaagt gtcacagaga agccctgaat cgctctctgc cgcttcgttc gatacaacca
    15721 tgaggaaaac catgcgaaat gaaaaaaatc gctcagaatg cgatacagcg cgttttagag
    15781 ggtatttaca aaacagtcgt tgccttgagg aaattttgat caagattgaa ctcctgtccg
    15841 gatcatgccg acagatcaca gcaacaaggc cgctaaaaat tgttgagctg cgttaaaagc
    15901 tgttaaaccg tggctgacta caacgaaacg ggaaaaaccg ctcagaatgc gttacagagc
    15961 gttgcatatc tcattgtggc gcaaccctat attagcctac aagttaattc aatcttgcag
    16021 aaaattagcc tgtaggttaa tataagcgaa aatggaggtc acatgtttag cgttgtttat
    16081 cacccggaag ccagggaaga agccacagca ttacccttaa aaatcagggt gaagtttgac
    16141 cgtctcattg gcaaactgga gtatgatgct cgattactgc gggagccgga cacaaagcct
    16201 ctcggcgatg gactttttga gatccgcaca atggggacag acattgccag gggcatctgg
    16261 gtataccaca aaggcaacac tatcatcatg ctccgggttt tcatcaaaaa gtcacagaaa
    16321 acgccagtga aagaaatcga tctcgccaga aagcggttag cggaggtact taatgaaact
    16381 ggtaagccat aaagaactgc ataacgagtg gatgcaggac gatgaatatc gtgctgcgtg
    16441 gcaggaggaa gaacgcaaag agaaactcag ggagcttctc gcggaatggc gtaagcatga
    16501 caacctgaca aaagcacagg ttgctgaacg catgggggtt acacctccgg tcatttcccg
    16561 tctggaaaat aacatcacta aagccagcat cgacacactg acgcgctacg ctcacgcctg
    16621 cggtattaaa aaaccagtca ttgccctgta ctgaggaatc agccgcagat gagtaaaact
    16681 gattatccgg catccgttga tcacaatgcc gccatgattg aagaattgcg cgcagatcct
    16741 gattatgcaa acgcttatct tgctaatgcc ctggaagaaa taaacgagcc tggtggttta
    16801 ggtggttttc ttgttgcgct acgtcaggta atcgaggcgc gaggggggat ttccgaagct
    16861 gtcaggaaat ctggccttgc ccgtcagagt atttaccgcg cattatcccc caacggtaac
    16921 ccgaccatca caacgcttgc acaacttaca tcggtagccg gattacagtt cactctcagt
    16981 aaatccagcc actaatctct ccagttcccc ctaagcgggg gaatttccat gccatcaaaa
    17041 ccgcagttat cccgcccgac gttcaccggt atttaatcgg caaatcgtac aattgcgtac
    17101 tggcaatagt ttaacggtgt gtattaatac acatttaaag gcgatgtgat agatgcgtgt
    17161 gttaatgcta atgtatgcat acattagcat taacatagag caaattctgg cgcgttgcgc
    17221 ccgtagttcg ctgacgctca cacgcgcagt acagcgcccc gtccagggaa accctggacg
    17281 gcgtaaactc gctggcgctc gcgctaactg cggcattctg cggcgcaaat cagcgtcata
    17341 gttgtctgtg agtcagtcgg gcttagcagg gcgggagggt gtccctggtt ccggttgata
    17401 acagtagcgg ctgcgccgcg cttcggggcg atgtggctcc tgtgctgccc tggtattttc
    17461 tttcgcccct tccatccgct tacgcggatt aaaaaacgca ctaattctca aataattcgc
    17521 tgatatcagg aaaaaagatc ttgataatac atctaaatag atgcattatt gtttcatcga
    17581 aaggggactg gctcctttcc ttcttaagtc caaacggaca ggagatttaa aatgaatatc
    17641 caggaagcgt taaatgtttt tggtttatcc ggtgaattaa ctgaaaaaga tatcaaagca
    17701 gcatacagaa aagccgcttt aaaatatcat cctgatcgca atcctttagg ggctgaactg
    17761 atgaaagcgg taaatgcagc ttttgatttt ctcatggcta acatcgataa aattaatcag
    17821 ttccagagta ctgatgaaca tgcgcgatat cattacggtg acgatctgga aagagtatta
    17881 aacgttcttt ctggtttatc tggactggta tttgaagtga ttggtaactg ggtctggatt
    17941 agtggagaaa ccattacaca taaggaaact ttaaaagaaa tcgggtgtaa atgggcagca
    18001 aagaaaaaac aatggtttta tcgtccagaa gaacataaaa gttactggaa tcgtgaagag
    18061 cacacgatag aagaaatccg agcaaaatac ggtacgaccg gacagcgcag ggcgacaggg
    18121 tggcaacgcg tggaaaccag agcttaatca gaaggggggc gagaagcccc cagatttcat
    18181 agccagcccg tcttttgggg catcgaaccc aaaaagacgg gaacagcagc cacgtagcaa
    18241 aaagggaaac agatgaactc tttttttgaa caatatcacc ctgtctttga agttgtctgc
    18301 cgtatcctgg ggaacggctg gcgcgtgaac aaacttgatg attgttcgtc tcgtataaaa
    18361 ctgacgtcac cgcagtttaa aaattactct gtgcatattc ggatggaaaa agagcgattt
    18421 tctgttgtgg ggagcgtgga tagtcgttcc tggcgtagtc cgcatcatgt ttgcacgtta
    18481 tccagaaaac ggaatcccgt tgatattgca gccgatatcg agcgaaaaat tctggtaaat
    18541 gcttcgcagg aggtgttaca ggcgattgag tatgagaaaa atcaggtggc aaaaaaggac
    18601 gaaattctga tcctgaaagg tatgttatcg caacttgtcc agcttgaaag ctggtatggg
    18661 gcattgacag gctttaaagc tgaaaacgga ttaaacggta aagtcaccga acagggcgac
    18721 cgttatgatt tgcagattcg gggcttgagt atagatcaac ttgttaaaat tacagggtat
    18781 ttgaaacagt tatgagaaaa aacaaagggc gattgactta ttatcttgaa gtgattgaca
    18841 aaaaatacca ttttgtaaaa aaaataagca gttattcaaa ggagttcact gaaggaaaaa
    18901 ctaaaacaac aaagataacg ttaagtgagc tggtttttaa tgataatgag gtcgaggcca
    18961 tagattttac aaaaaatggt ttaagacctg ttgataagaa tgttctctta acaatgatga
    19021 aagaatataa ggagagtgat gcatgactat tgaaaataca ccggaaaaca taaagaaatt
    19081 acgtaaaaaa attggcctta ctcagacgga gtgcggtgaa atttttggtg taggtttaag
    19141 tacatggcaa aaaaaggaag ctaaaaccca caaccaacta aatttgtcga aaggtgaatt
    19201 tgagtacctg ttattacttg caggggaaca tcctgaatac gtcctttgta aaaggaggaa
    19261 aaatgacctt tgatgatttt atttttgctt gtgtgtttgt atttgccatg attcatagct
    19321 tttttacgct aaagtatttt aggtttctta tgaaatctaa attaatttta ggaggagtta
    19381 caataattca tatgttaact tttttctatt tttttatgct gctctatgaa taaccaactg
    19441 caattagtac caggagttgc gcccgtagtt cgctgacgct cacacgcgca gtacagcgcc
    19501 ccgtccaggg aaaccctgga cggcgtaaac tcgctggcgc tcgcgctaac tgcggcattc
    19561 tgcggcgcaa atcagcgtca tagttgtctg tgagtcagtc gggcttagca gggcgggagg
    19621 gtgtccctgg ttccggttga taacagtagc ggctgcgccg cgcttcgggg cgatgtggct
    19681 cctgtgctgc cctggtattt tctttcgccc cttccatccg cttacgcgga ttaaaaaacg
    19741 cactaattct caaataattc gctgatatca ggaaaaaaga tcttgataat acatctaaat
    19801 agatgtatta ttgtttcatc gaaaggggac tggctccttt ccttcttaag tccaaacgga
    19861 caggagattt aaaaatgagt gcatttgctt tcagaaccac ctttaaaccg actggcgacc
    19921 agcaaaaaga cgctattact catatcgaag ttatgcagga acgagcagta aaagcctttg
    19981 tttcctggat gagcagccag gagggtacag aatttttaag cactttgcag gaaatcacaa
    20041 cagaacttga ttcacttatt tatgcggtag agtcccacac ccctgttttc agaaagaaag
    20101 ctagtgaact ggaaacgctt ttagctcatt acaaaacatt gctgtaagtc ttcaacgggg
    20161 catttgcccc gttatacgac tattttttaa tccaaatcta aaacaggtgg agtttaaaaa
    20221 tgactcgctt accttttatt gaatcaacca cgcaacagat ttttattttt aatactgtga
    20281 cgctttgtac tattgggtta atccatatag agactggtaa agaatatgtt gtagtattta
    20341 cagataataa taagattcgg gattacaaaa ccggaattgt tcctcagttt ggcgaaatga
    20401 agccgagtga tattgattta atacttttct acagggccga atatgaaaaa tactttgata
    20461 gtttaaaaat aggtgatgaa gccttaaata ttaatgaata tataaaatgt atgcaatagc
    20521 catatattct ttaaaggtgt gatcaggttg ttccaccaac ctgatcacgt tatcgacaat
    20581 caaaacgaaa cgaggttttt aaatgtcaac gcggcagatc gtacagcttg ctgattccct
    20641 tgtcaaaggc tgggaaacca gaattccggc aatgaaattt agtgaatggg atcaatttcg
    20701 atggtggtta aactatctgc aaggatatga aatgttttaa ataaaaaagg ggcttccagc
    20761 ccctttatat cttttgacaa aaatgccgaa tgtaactata attagttgca tggctatagg
    20821 ggatggcgtt atggggaaaa cagataagct actggcaaag tttttaaaca gtaaaaaaac
    20881 gtttgaatgg gatgaactgg tcgttttgtt ttcttctttg gggtatgtca aaaaggaaat
    20941 gcaagggtca agagtgcggt ttttcaatgc tgaaatcaac cacaccatat taatgcatcg
    21001 tccacatccg gaaagttata tcaaaggtgg tacgctgaaa gcaattaaac agaatctgaa
    21061 agaggctgga ttattatgaa acatttaaaa tataaaggat atttaggcac tgttgaacca
    21121 gattttgaaa acaatgtcct gtatggaaaa ctggcattta ttcgtgacct ggtaacttat
    21181 gaggcttcta cattagctga actggaacag gagtttaaaa catcggttga tctgtattta
    21241 cagtcttgtg tggaggatgg aaaggaacct gataccccgt ttaaaggcgt gtttaacgtc
    21301 aggcttgatc cagaactgca tcgtcgggta gcagaaatgg cgatggaaga agatttatcg
    21361 ttgaatgcct ttgttaataa ggctctggaa aaagaagtca gtaatcatcg cgcaggggct
    21421 taattgccct tgttttttat gccctgtaag ggcatgggag gcgctttgcg ccggaagccc
    21481 cgcagcgcag cgaggactta aaaagcgtta cggcgtcagc cgtaacaatt cccagccctg
    21541 ccaggcctgt tttttctttc acaaatcttt cagctatacg ttttccagat ggtcgaagac
    21601 gaaagaacct ttcagcaacg aaatctggac atatgcagag gcgattttat agccaggcac
    21661 agtgcaacat atggtacaat caatgcagga tagacaatca tggtcaaaat gttaacattt
    21721 tatccatgat tgtccaaaaa acgatgtttt tgcctgtgcc tgccgcaggc tctgttgggg
    21781 tgagttatga agatgatagc gttcagactt agtgatgatg agttaaaact tgcagagcat
    21841 aacgctatat caagtgggtt taccagcatc aatacatttg ccaggcataa tgtgcttaat
    21901 gttgatgttc aaccatcaaa tatacctgtc agcaatgaat catcaaaggc tgttaaaacc
    21961 tgtttatacc ctcatgaaat agaacttgtt aaacgtaatg ctgcccttca cggcatgagc
    22021 atgagcagag aaattgctat tcgtgtgcgt cagtctttgt taaagaatga agtctgtctt
    22081 taccctgatg aagttaagga acttaaaaaa ctatcaactg ctgtagatcg tgttggtcgc
    22141 aacattcatt ttatcataaa aggtgaaaga ttctgtacgg ttaacgatcc agatttcaga
    22201 aaagacgtta ttgaagtgat tgaactgtgt aagcaaattg attcaaaact tgaaacgtta
    22261 accaagagtg ttgttaacag atttgggtga tttatgggtg tgtatgtaga acaggaatac
    22321 cgtattaaac gcgctaaagg gactgggcgt gatccgaaat ctcctaagtt atcgggaaga
    22381 catatacatg ccagtaaatc ggcttttaat cataaagtca gacatggtgc ggacaagaaa
    22441 gcatatacct ggacacctac aaaagaagtc acttttaaaa tcactggctc aggtaaaaca
    22501 gccgcaggca tcaaaaacgg tattgattac attacccgta atggtgaact tgaggcttac
    22561 tgttatgatg gaaaaggttc agagcaaaca gggaaaggag aagactttaa cagggagttt
    22621 acttcaactt tatctaaagg aaatgattac tcccggacat atcgtggaga aaacatcgat
    22681 catgtgaaaa acatggtctt ttcaccacca ccagaagctg gagtaagcag ggaagacgct
    22741 ctgaaagcta cggtagaatt tcttaaagag acttatccaa accatgcttt cgttgccgta
    22801 taccatgatg ataaagaaga tcatcctcat gtacatgtta atattaaact tcgtgatgaa
    22861 gaaacaggaa gaagattaag acttactaaa tctgaaacca ggaagttcag aaacggtttt
    22921 catagaaaac tgaaaggtat gggatatgat gttactgcta cctggaaaaa agatcccgaa
    22981 cgtaaacggg agattgagcg attacaggct gaaaatccga aaagactccg gaatgtttac
    23041 aaggttgtgg attttgggga gacttcatat cagaataagg ctggggaaaa acgaacacct
    23101 ttcctcactt atgaaacttt aaaaggtgga aaacaggtta cgatttgggg taaagacctg
    23161 aaaaatcatt tcgagtctga aaagctccag ccaggaacgc ttatcaaagt taaaaaactg
    23221 gctcctacgc ttgtacgtag tccgatgttt aatgatgatg gaactgttgc aggctacagg
    23281 gaaacgcatc gcaataactg gcagattgaa aatattgccc ttgagcggaa cagagaacgt
    23341 caggttcatg agcgtgaaac caggcagccg gaagagagcg acgttaaaaa gcagctatcc
    23401 agaaaacatg agcaaggtca caatatcggg tttgctcttg aacacgggtt tacaaaggat
    23461 tcagaagaac ataaaaaact aagaatacag caagagagga actggaaagg cctgggattt
    23521 taatttgatt tcggcgcagg tgaacaaagc ggctactttg ctcacctgct aatcacaaca
    23581 acctacatgg gaggttatca tgactgagca tgatgctata cgcatttcgc aacttcatca
    23641 aatctttccg gaggttcagt taactgaacg acagaaagat attgcagtga tgtatgtaat
    23701 tggttgcaca gtcgaagaaa ttgcgtcaga aaaagggata acgactgatg gtgttatgta
    23761 tcatctgaat ttggtaaaaa gagctgtagg tagtgcaact ctggcaggag tccgcacaat
    23821 tgcgtttctt aggatgatgg caatcgtctt aacaagggag tcataacatt atgagttata
    23881 taaaaaaagt aaaaattctt tctttggttt tgttctcaat tgcattgagt ggatgtggtg
    23941 aggaaatcaa gaccgttgat tggtggcgaa atcatccgga ggaagcgatc tcgaaggttg
    24001 aagagtgtaa gaagtccggc gatgcgtcgg ataattgtaa aaacgccaag accgcgttgt
    24061 acaagaatca gcaacaagat gcgcctgtgc ctcaaattaa ttaaaagata caacccagac
    24121 aggtgttgat actaaattat agccgaccac taggtcggct tttttgtcat catgatttgt
    24181 aatatatgtc tactaaagtt tttgtagttg tataacctcc ttgttttgat aatcctattc
    24241 gcatctaaaa caaatccaaa acacacttat agtggattga ttaaatgaag gagaaaccag
    24301 ataagtcatc ggaaaaaggg gtttatgtca caataaaact cgatcccagg ttgaatgcat
    24361 ttatcgaaga gaaaacgaaa acatctttgc ttagtaagag gaagcaaatt atttacttat
    24421 taatgcagag tatgcgtatt gatggatata tggagcgtta gctatggcgt ctttattccc
    24481 agccttgttg ctgtgtgcgg cgtcagttca tccggatacg ataaatgata ttgcacgggt
    24541 cgagagtggc ttcaatcctt atgctgtggc tgaaattatt cctgaaaggg aacgcggtag
    24601 ctatggcaaa agtgttatca gtcatatgcc caaaagtaag gaggaagctc ttacagttat
    24661 cagagaaatt gaaaacagaa aaagacgtta ttctgtcgga ttgatgcaga ttaccagcag
    24721 taatttttct ttttattcca cgtccgcaga aaaactcctt gatccgtgtg aaaacttgtc
    24781 tgttttcgaa aagattatcg tggattgtta taaacgaggg aggagcctgg agaatgcgct
    24841 tagttgttac tatacaggaa attttagtaa cggtaagcga aaagaaaaag aatttaataa
    24901 tacaagttat gttgagcgaa ttggttatac agggaacgaa aaaaaatatg ttgtaccagg
    24961 tacaagaagc aacgggggag aacagagaaa aaatcgttca cacaatgcgt cagttatctg
    25021 gcccgaaacc attctgaaat ctgcttttgt tgataactca catccaacaa aagttattaa
    25081 ttaacaggac ttataaaatg tcatttaaga aatcagtatg taatcgtatc agttcatctg
    25141 tcactgctgt aatgcagcgt aaaaataagg tagttatggc agtcgccggg gcaacagttg
    25201 catcaccagc ttttgcagat ggattttcaa aagcggaaac gctgctggaa aaggtcaaaa
    25261 cagggcttgg tggcctttca ctggtaacag tgactattgc ctgtctgtgg gtgggctaca
    25321 agattctgtt cggtggaagc acacttcgtg aatgtgctcc cattatcatc ggtgcggttg
    25381 ttattgccag tgcggctgaa gttgcatcaa tgatggttaa ctaataaagc ggggacgata
    25441 gtatgtctac actttataaa gcgatgacac gccctgctat gtatgtgggt gttcctgtcg
    25501 tccctcttac tgtggttgca ggggcgttat ttctggcggg ggtttatatc agcaagctga
    25561 tctggctggc tattcctgtc gcagttttta ttctcagaat gataactaag caggacgacc
    25621 acatttttaa tctttacttt cttaagctga aaatgctcgg aaactcagtg tgtaatcgtt
    25681 tttttggcgc acgagcgttc ctctccggac aatatgaagc tgttgaaatt gatgagtttg
    25741 ttaatgccat gaaactgaat gagcgaatca ctactggtaa atatatccca tattcaagcc
    25801 acgttgataa aaacatcgtc aaaacaaaaa acggtgatta tgtagcgaca tggcaactga
    25861 tggggattaa ctttgagtca atctctgtgg agatgttaga aactattgac tcacaggttg
    25921 ccactcttgt tcgttcattt tccggactgc ccgtttcatt ttataaccat tcatgcaggg
    25981 cgagttttta tgatgccttt accacaaaat caggtaataa atatgctgat ataatatcag
    26041 attgttatta tggttcgatg aagaaaaata aattcaaggg gaacactctt tactttacgc
    26101 tgatctacag accagacggg cgtgtagaaa aactggaaaa acgcaaaaaa agtattaaag
    26161 aaaagaaaga tgatattaac attcatgtga agagaatgaa tgaaatgatt aatacattct
    26221 ctggcgctct tgataaattt acctgtaaac ttcttggtat gtatgaggag aacggaaagg
    26281 tattttcttc tcaactgtca ttctataatt atcttctgac agggaagttg caaaaaatca
    26341 gagtaactga ttctccggtg tataacgttc ttggtggagt ggatgtattt tttaatcatg
    26401 ataccggaca gatatgccgc attgatggaa atagattctt tcgttctatt gaaattaaag
    26461 atttctgtag cgagactgca tccggtgttt ttgatgtgct ccagtattct gatgctgact
    26521 atattattac gcattcatat acatccatga gcaaatcaga agcattgagt accattaaac
    26581 gtgcggaaaa acagttaaag agcacagaag atgatgcggt tactcaattg caggaactgg
    26641 aaaaggcaaa aaatgatatt gtgtccggtg atatatcctt tggttactac catttcacgc
    26701 taatggtaat ggcggacagt atcagggagc ttgacgaatc tgtaagtaaa attacggcag
    26761 actttactga cctgggtatt attccggcat tgtcaaccat gtcactgcca gcggcatatt
    26821 ttgcccagct tccggcggtt tttcatttaa ggccgcgttt atctccggta tcgaatgtaa
    26881 attttgtcga actggcatca ttccataatt tctaccaggg gaaacgcgat aaaaactgct
    26941 ggacagaagc ggttgctatt ctcaaaacac caagcaaaca ggcgtattat ctgaatttac
    27001 ataactcagt actgtttaaa gatgaaacag gtgaaaagaa tcttgctaat actaaagtta
    27061 taggaacggc gggttcaggt aagacaatgt ttctgtcata tcttgcctgt tcattacaga
    27121 aatacaataa ccccgaaaca tttgccgatt ctgcaaaaaa taaaaagtta acgtgtgtct
    27181 ttcttgataa ggacagaggg gctgaattat gtatccgaat gcttggtggg gaatattaca
    27241 ccgtaaaaag cggtgagccg acaggatgga atccttttgc tctggaggca acaaagcgta
    27301 accgtatttt tgtcaagcaa ctaatggaga ttctgtgtac cagaaatggt gaaagattat
    27361 cgacaagaga aagattgctt attagcgaaa gtgttgatgc tgtgatggat tttcctcctg
    27421 gcgaaatgcg ggaatatggt attacccgaa tgcttgagca tcttatgcag agagatgatc
    27481 gggatgagca ggagaacggg attatccttc gtttgtccca atgggctaat ggtcaggctc
    27541 atggctgggt ttttgataat gctaaagaca cattcaatat tcagcatgtc aataattttg
    27601 gcattgatgg cactgagttt cttgatgatc cgatggtttg tgcaccaatt actttctatc
    27661 tgctgtatcg cattacgcag cttcttgacg gtcggcgtct tgttattttc ctggatgagt
    27721 tctggaaatg gctacaggat gaagcattca gcgattttgt ctataacaag ctgaaaacaa
    27781 ttcgtaagct gaacgggctg gttattccgg caactcagtc tccggatgaa atactgaaga
    27841 ataagatttc acgggctgtg gttgaagtat gcagcaccag tatttatctg gctaaccctg
    27901 atgccgatta caatgattat gtggaagggc ttaagctgac accagaagaa tttaatattg
    27961 ttaaaaatct tgatccaatg tcgagacagt tcctgattaa aaagagcagt cttaaaaagg
    28021 gggatggaaa atcattttca gcacttgcga cactcgattt atcgggactt ggtggatatc
    28081 tgaaaatatt gtctgccagt gcagataatc tggaaatttt tgaaagtatt tatcatgaag
    28141 gaatggagcc tgatgactgg gttcctgaat atctcgaacg ggcaatctga caggtgaatt
    28201 tatgaaacgt ataaaaacat ttctgctgat atcattattg acggcttcat tttatagcag
    28261 cgcaggtatt ccggttgctg ttgatgccag tccggaatgg gctgttgaag ccgcaagatg
    28321 gacagaacga ctcaaacaat ggtctgaaac tgcgcaacat tatcagagtc agattcaggc
    28381 atataaagac cagttagcca cggcaacagg tataaggaat attacggcat tcacaaatga
    28441 actaagtaat ctgcaatcag aactgacaaa tatttataag caggggaaca gttatatttc
    28501 tgattttacc agtaatcccg aaggcgcatt aagcagccag gccaaaaatc tgttcagcaa
    28561 gtatggagcc ttcgatatgt gcaatacagg ctatgaacgc aatgataatc tctgtaaagc
    28621 acggattgtg tcaacggctg ccagtattga acaaggaaat gagatcaata agcagttatc
    28681 aagtgcaatg tctcagattc agagtttaag tacccgaatt gaggcttcaa aggatatgaa
    28741 agaatcccag gatttggcta acgcattaca ggcgcagtcg ttaaaaatgc aggcgataaa
    28801 aatgcagtat gatgtctgga atagcaaaaa tcaggctgac acggcgatgt tgaaagaaca
    28861 acaaagggct gaatataagc aacaacagat gaacgcacca atacctacga ttcaatgaag
    28921 gaaaaggtat gtcattcttt gttaaatata acacaaccgt tatggaagca attgataagg
    28981 ttggagctac ttatcaaagt caattcactc aagatataat gtcattagtg acagtatctg
    29041 ttacgttata tgtactatgg aaaggctatc aaatactcgc cagtaaaact cagactccga
    29101 tgcaggattt agtttgggat ttatcaaaat ttgcaatcat aatcatgttt ataacaaatg
    29161 cagatggata tttgactgcg gcaaccaatg cattgcaagg catgaaagat gggctttctg
    29221 gcggagttag cgcatggcaa accttagata acttatggga gaaaacacaa aatcttgcgg
    29281 aaaaggtata tcaaaaagat actgatttca ttcctttggc tggcgcatta ggtatgacgc
    29341 ttgtttgggc tggatcactt attttaatga caattagtgc tgttgtgttt ttaactgccg
    29401 atattactat gaaattcctt attataacag cgccaatatt tattttctgt ctgatgtttg
    29461 gttttattag agttatgttt aataactggt tgcaatctct attttctagc atcctgactg
    29521 tgctatttgc cagtttagta attcggatag ctatggattt tcagggggat atattgcaac
    29581 aagtatctaa tgcaaccccc aatagtaatg ttatgaccgt aagtgcaatg ggatttttag
    29641 ccggattgtt gggcgcttta ttggttctta tagctaaaag ttttgctgtc cagttagcgg
    29701 gtgcaggtgt tgaaggtgct gttcagggcg ccgccatgat ggggctgggc gctgctggta
    29761 tggctactgg taagtctctg atgcttggcg gtcgtgctgg tttaggtttt ggcttaggga
    29821 tggccggaag aacgggcatg aattctttat cagggaaagc agggaatctg atggggcgtg
    29881 gtgcgcgaac agccgctgaa tgggcgggtg aaaagggata tcaggcgctg gctccgacag
    29941 gtgctttggg gatgaaggcg agaagacttg catccctgga aaaagcacga gcgaggaacg
    30001 ccgcatgaaa ataatgaaac gtttttttta tgtgatgtcc ctgaactgga tactggtgtt
    30061 cgttgataaa catatcacct ccggatggag caggaagaga aagctaataa cccagcttgt
    30121 tattttaatc acgggaatta ccttatttaa ggtcttaggt ggaatcagtc agagctggtt
    30181 gtgacatgct tcattatttt gtcctaatcc ttcttttagg agtgtttacc tgcttcgcag
    30241 gaataagact tggtttaggg cttgcgggga aatggagaaa gggtatggat cttcgctttt
    30301 tgcttcttat tggtgggatt ctttttcttc atcttggcct ttatctctta aaggtgttcg
    30361 tgaacgctta ataaggtgaa tttatgcgat gtgtgattct tttgtttttc ctgtttcaga
    30421 tttccggatg taccacaagg aataaccttc cttctgatgt ttccggcgaa ctggaaccca
    30481 ttaaccacag ccaggtaatc agttatgagt gaaaaaatcg aaaagaagat tgagacagct
    30541 aaatccttcg aaagacaact ctatgcagaa aatgaacggt ctaagaaaaa tgcatggcgt
    30601 gttgcagtgg cagcatcatt actgtcctta tgtcttgggg ctgcaatttg tgttcttgtg
    30661 ccattaaaag aaaaagagct tgctattgtg gctgttggcg aaaaaacagg ccgtacagaa
    30721 ctgattactc aggttaaaca ggaaaagatc ctgcaatctg aagcacttgg gcggtatttt
    30781 gtaaacacgt atattacttt acgtgaaggt tataattatc cgtctcttca gtatgattat
    30841 gagactgtac agctatatag ctcgaataca gtaaaggacg attatcttcg tctgtataac
    30901 agcgatatgg ctcctgataa aatttatcat aataacggtt cttacgttgc ggttgaggtc
    30961 atctccaata ttatttctga cgcaaccgcg ccagataaac tggcctctgt gcgctttaaa
    31021 aaaacgacga gaaacttcac gaccggacag gtttcagttt catactggac ggctcgtgtg
    31081 acatatcgtt ttgaaccaga aaagtcggtt aaaagttcca gtcgtgagct taatcctctc
    31141 ggttttactg taaccagtta ccagacagat cgggaagtca ggggggaatg atgaagaaat
    31201 tatttattgc tacatgttta ttgcttcctg ggcttgtgta ttcagcagcg actccgttac
    31261 cttctggatt tgatgcaagg atgcagactg tgagttataa cggtgcgaat acgaccgtta
    31321 tccggtcaaa gacaggattt ctcacatcag ttgtttttga tgaaggtgag gctgttatca
    31381 gtgcaaaggc tggttttcct gccggatggg aaatcacaac cgatgataat gttgtttaca
    31441 tcaatccgcg tcccgttgtt caggaacagg aaggcgatga aggcgaaaaa ctgaaaaagg
    31501 ttttccagcc aacagaaaag gaatgggata cgaatctttt tgtcagaaca acaaagcgga
    31561 tttacagtct ggatctaatc cttctgtcag aagaaaaaca agcgcaacct gcttatgttg
    31621 tacaattccg ctatccatca gaaatagcga aaaagaatgc agaagaagta aggctggcaa
    31681 aagaaaaaca ggaaaaactc agacagaaga aactgatttc tgaaagtttt gaaaaagccg
    31741 atgcgcctaa aaactggaat tatttcatgc gagtcaatga aaaatatgac agtcgtcgta
    31801 tcgcccctga ttttgcttat gataatggca tatttacctt tttaggtttt aactcaggga
    31861 aagtattccc agctccattt gctgtaagag atggtcagga acagacactt gcttttaatg
    31921 tggaaacaaa aggcaagtat aaaattatgg ttatccacaa cgttaatgac aaatttgttt
    31981 tacgctatgg aaacagcgtt gttggtgttg tgaataaatc tttcggaaaa gtattaaccg
    32041 accagaggaa tacatcttct cctgcggtag aacgtgttga ggtgaataat gactgatatg
    32101 aaaaaaacag atgatttagt tgatgatgcg aatcagtcaa agctggaaag taaacccgtt
    32161 catgatatcg gtgatatcag gaacaaaaat aatcgtatgc gttctggctt tctgtttggt
    32221 ctgatggctg tattagttat tggtattttt gcgctgaaaa catataaaaa ttattttgca
    32281 gatgaccagc agaaagcatc agaatcaaca ggcgatacca gcatttctca ggtaagtaaa
    32341 atccgtactg gtcttggtca gaattttgac cctgttgaga acaaagcaat tatcaatcca
    32401 ggcgctactg gttctggtaa tactgtttct gacggtcata aagaagtgcc acaggagggg
    32461 ttcaggaaat atttgtcaat acctgttgct ggtcagggag ggagtcagac tggcgcgagt
    32521 ggcagcagca ggacatcgca gacatcagag ccacaggaag aaaggaaaga atcaaaagaa
    32581 aatgtgcctg gtaaatcagg aatgaaagta actgcgatta atctcgatcc tgatctctat
    32641 attgaggaaa acaggcttat accgtgtgct ttaaccacac gctttgtttc tgatgttgca
    32701 ggtcgtatca gttgtgtttt tacagaagat gtatggagtg ctaatcacca cacaaaatta
    32761 ctggaacagg gaactaaggc ttttggtcgt taccagaccg gaacgctgaa tcatggacag
    32821 ggcagaatgt tcgttatgtg ggagcagttg cggacgcctg ataataaacg aatcgatatg
    32881 gtaaatacag cagcagctgg tcccctggga gaagcgggca ttgatggatg gatcgattct
    32941 cacttctggg agcgttttgg tggttctctt atgctcagta tggttcagga tgtagcggcg
    33001 gcggcggcgg ataatgcacc tggtaaagat cgtaatgtgg attataccga aaactcacga
    33061 caggcaatgg ctgaaatggc taaagtcgca cttgagaatt cgataaatat tcctccaaca
    33121 atgtataaaa accagggtga cataatcact attatggtcg gggaagacat tgatttttct
    33181 gatatctatg agttaaaggt aaaatagtat gagtggcgtt attcctgtca gcattagcaa
    33241 taaatcgctc gatttttata aaaatcaagt attccagtct tttcttgata ttgaagggct
    33301 aacagaaatt gctgtcaacc gtcctggtga aatctggacg gaaattaatg gtgactggac
    33361 attccataat aatgacagtg tgacctttga tttttgtaaa cgtttttctc atacgctggc
    33421 atcatttcgg ggagatgaaa tcggcgatac caagccatta ctttcagcaa cactggaatc
    33481 aggagaacgt gtacaggtcg tttttcctcc tgcatgtgag agaaatacta tttcaatcac
    33541 tatacgtaaa ccatcgacac ggcagataac acataaagaa tatgtggcga acggttttta
    33601 tgattatgtc cagtcaggaa aaaaacacag gacatacgat gatgagcttc ttgatttatt
    33661 cagagcgaga aatatcgctg cttttatgga gcttgccgta gcagcaggga aaaccattgt
    33721 atttgccgga gcaacgggtt ccggtaaaac aacttatatg aagagtctta tcgatttcat
    33781 accattgaat acacggctga ttacgattga agatgcagag gaaatcaaat tttttatcca
    33841 taaaaattat gtgcatcttt tttacccttc ggaatccggc agtgattccg gctctatcat
    33901 aacagcagcg aaattaatca aatcctgttt gaggatgaaa cctgacagaa ttttactggc
    33961 ggaaattaaa ggtggcgatg cctgggattt tgtgaaagtt gcaggttctg gtcacagtgg
    34021 aagcatgacg tccattcacg cggcctcggc aaaagatgcc atcattcaga tggtgacaaa
    34081 atgttatcag aacagagaat gtcagaatct tccttttgat gttcttcgta aaatcattat
    34141 ggacagtatt gatattgttg ttcatgtagg cagggatggt gttgtcaggc atatgagcga
    34201 catctattac aaaggggctg aatgtgaaaa cttttaataa gtcgcaatct gtttttatat
    34261 tcgctgttat gcttgttgcg gcatggtttg caggttcatt tattttcttt gtgctttact
    34321 tcagccagat aaagaatctg aaaccattga aggctgtgtt cagatccatt gatgcgtaca
    34381 ggatggatat ttttacagac agccttactt tatctgttgt gactacggat atcagagttt
    34441 tagcctttgt tgcacttgga gcaggatttg tcgtgtctct tatcatccct gttgcggcgt
    34501 tgataaaact gaacgagaag aaagaaaata ttttcggtga tgcgcgattt gcaacaatta
    34561 atgatattcg tgagtctaac agtttcacgc ttgacggtga cgaaaaagac gggattatcg
    34621 ttggtataaa agacaagaaa atcatacgct atgtgggagc agcattcagt gctatgggag
    34681 ccggaacaag ggctggtaaa ggtgctggta tagtcatcac taatcttatg aagtactggt
    34741 ggagtgttat tattctcgat ccaaaaaggg agtgttttaa tatcaccagt cttatcagga
    34801 aggtgatttt aggtcatgag gtttataaat ttgatccctt tagtccggta acgcaccgct
    34861 ttaacccttt gtattatgtc agcatgggaa cgagtgaagg ttttaatcag cttgaaaatc
    34921 tttcgttgat tatttacccc tataagacag atggtgcgga tgctggtagc tatcttaata
    34981 agacggcggg tggtgttttt aaatcttatg ctgtcgcttt atggtttatg attaagaatg
    35041 ataaggctgg actaaaaacg cttgatattg agcctgtctt ctcaatgtct aaaattaatc
    35101 agctttttga gcgtgcagaa cccgaacatc ttctttcatt catgaatgat attcgttcag
    35161 aattaagggg gaaagacaaa acgcttgctg atattggtgt cgctggcctt aaggcattca
    35221 ttgagatgga ggataaaaca aaagcacaac tcaaaagcaa ctttcttaat ggattatcac
    35281 cgtttgctaa ccccaatgtg gcaaatgcta ctgatggaaa tgattttgat ttgcggcagg
    35341 tgcggaaaaa gcggatgaca atttatttct gtatttctgg tgataatgcc aggttggctg
    35401 aaaaaataac aaatattttc tttcagcttg ctatacaggt gaatcttgaa aagatgccaa
    35461 cggatgatcc ggaaataaag catgactgcc tttttctact ggatgaattc ccgtcaattg
    35521 gtgctgtaga ttacatcaag agtaaatctg gtctcattgc tggttacaag ctgaaattgt
    35581 tgattgttta ccaggtcggc tctcagcttg aggaaatcta cagttatgca ggcagtaaaa
    35641 cattactggc aagtgcaccc tgcaaaattg tttattccgc ttctgatgtt aaagatgcgc
    35701 gggagttatc agaagcgatg gggacacgaa cagtaactat cggttcgaaa agcaaaagtc
    35761 gtagccgtgg aggaacatcg agatctgaat cagaaagcct tattgagcgt ccactggtaa
    35821 caacaaatga actacttaca ctgaaattta gtgaagaaat cctggcaatg aagggagaaa
    35881 acccgattcg ttgtgaaaag gcattctact atctcaatga gtatttcttt ggtgactttg
    35941 tgaaggttgc tccggaactt gcaaacattt tccccaggaa gaaaggaaag ctggttatgc
    36001 ctccacagaa agtatttgaa aatgaaatcg tcgcaaaagg gtatctggta gtaaaagatg
    36061 ttcctgatct cgataaagcg gcataaagga gaacatgatg aagaagttag tgtttttatt
    36121 gatttccatt cttgctggtt gttcatcacc gccagagcca acacccgtgc agtttgaaaa
    36181 ggcaaatgaa gtgatcaatc cctcattgcc atatgtcccc gattttcacg gtgtcataaa
    36241 gtcagacgtt agcggtaaag gatgggttta tgagatcact tccttatccg gagtacaggc
    36301 cagaacgccg acgttttatt acgctctggc tcatgcggac aggattgtag tgacaacaca
    36361 tgatgctggg ctgtggtttc gaatcagaga tctgttgaag atggaagggg caacagcagt
    36421 cgtggaatgg cgaaacgaga aaagtttttt acctgaacag gtaaaaatag ttttcattaa
    36481 agcacaaaat gaggtgaaaa atgactggaa aaaatagagt ggttttacca gccttgctgg
    36541 cgttaggatt aatatcaaca aatgctaatg catctgaccc ttgcgcttcg gtactttgct
    36601 tatatggaaa agcagtcggg caaggtggag ggagtgaatg cagaagtgct gaaaaggatt
    36661 tttttaatat tctgaaaaag aaaaaaggaa gcattcgctg gagtaaaact tttgatgccc
    36721 gtaaagcatt tctgaatcag tgttcaacgg ctgatcctgc tgctatatca aaaatcatga
    36781 gtaagttcgg caaggttaaa gggtagatga tatggaaaag caaactactg atttactgaa
    36841 tgtaatcaag acaggacact ctggctcaat agctggtaat cctgctcatg cactggatga
    36901 taagactatg aacgccatca ttcataacta cgtggcaacg attgtgctcg gtaaagcagg
    36961 taactgcaaa gaaactcctc tcacaaagta ttgttcgagg actatgccag agcgtatttc
    37021 agttgaagaa attaatgagt ttaaaattta tccagagtta ttctgaacgg agataacggc
    37081 aaacgccgca gattccggat tttaatccgg gatttgcggg gttgaacaac cgaagggcgt
    37141 tagtttcctc gtaatccatg aggtgtatat gaaagcaaga agtgtgagag ttgccggaat
    37201 tgaaattatc gatagtgtta aaacggtcgc ttttgttttt actgaaacct tactgtttat
    37261 ggtctggttt tcggcaattg tctatgggct ttatcgtgtt gttatcgttt tatgggatga
    37321 tcctttaaag ccgcaatcgc tcatggaatt tcttaatttc atagttgagt tgtatagcta
    37381 tgtacttcct tcgttggctg ttatcgcagt ggctttaatc gccgttttat ccatttgtaa
    37441 aatactctca gcaatatggg agggaagaaa gcaatgagac attttcttaa ggctctttcc
    37501 tttgttgttt ccctgttacc agctacattg tgtgcggctg aaatccaggg gaaagttatt
    37561 cgcgttctcg atggcgacac catagaagtt aaaacactac ccgcaaaaat tgttgtgtat
    37621 gaagttccga ttcgagtccg attgataaat attgatgccc ctgaaaagaa acaacctttt
    37681 ggacgctggt caacaaatca acttaaaacc ctgctcgcag gccaatccgt taccgtctct
    37741 tatacgcaga cagaccgcta cggacgcatt atcggtcgtg tgttcacgac gaacggcacg
    37801 gatgccagcc gctttatggt tcagtctggc gctgcatggg tatatgaacg ttacaacgag
    37861 gatgagtcat taccggctct gcaacgggaa gcgcaggaac aaaaacgcgg tttgtgggcc
    37921 gacgcaaatc cggttccacc gtgggagtgg cgatacaaac ataactaact gatagaggtt
    37981 tttatggctt tatcccccaa agaaaagaaa gagttacaac aacgcttcga aaagcaatta
    38041 ctacctgacc ttgatctgtc atttgaacta aatggcgaag tatataaatt taattttgat
    38101 aaaaatgagt caggtgacta tatcgacagt tttacacaag cagtatgggg aggttatcag
    38161 gatgccgagg aatgggaaaa atatggtaaa catcaggaga tagaattacc tgaatgccct
    38221 ggaccagtcg agggttggtg cgactgtgat aaatgtaagt cgatgttttt tcataaagag
    38281 aaaaatattt atgtttgcct ctcctgccat aaacaaacag agccatttct tccaattgac
    38341 tggaactcaa acgattacga ttggctacct tatgaagatg aatactaatg ctgaatactt
    38401 cacagtcata atggatgaaa tggcggcata aaattaagga ggcttaaatg aatatccatt
    38461 tattttcaga agtattgttc tgcgtatggg ttatagcttt gattgtgatt ttatttatag
    38521 ttgttaaata ttacaggcgt gtccattaca gactcaattc actgtctgaa acgataaagc
    38581 gcacacaggg cggtgttaat aagcgaatat ctgaaaacag agaactgctt gaacttataa
    38641 agaatcaaca tcctgaaatt ctggatgaat atccgtgggt aagtggttgg cttgattcac
    38701 aggaaaagtt tttggtcgct cttgctgata agtctggtat cgatatatac agaatgaaag
    38761 ttaaggagta acagaatgtt gggtttaccc tatccggcag gtcactggat gtattcgtta
    38821 tacgatttac tcgataattc agtgttcgtg gtttgtttct ttgccttctg ggtggcaacg
    38881 ggtcaatttt tattaagaac tgtacacaga aaatttaata tatctgaaac agttgagatg
    38941 gctatcatcg ctttattagg gatactaatg actctgtctt tttatctttg tgcaatttta
    39001 aaggcttctc tttaaatcag aggataaaaa caatgatgac aaaacatgat aaagaacgat
    39061 tcaataaaag aatcggtggt gaagtgcaga ttagtgctga tatccgtgtc aatgacttaa
    39121 tgacagttcc ttttgccgcg ttaataaaag ctgacagatg catcatttca aaaattgcat
    39181 catattcagg ttttgcagta acggcttttt taaggattaa agagtgggat atcgcaacga
    39241 atatacttaa ccgtgagggg atttttgctt ttaatagcga tgaacgcagg ttcagacatc
    39301 cagtaagtga agataactgg caacaggcag tgtcagaaga acgagctatt cgctgtgcaa
    39361 acagactaat tcagtgtaaa ggataacaaa atgagacttt ttatcgcaga aaaacccgca
    39421 gtagcaaatg atattgttaa ggcgcttggg ggtaatttca cccgtcatga tggctggttt
    39481 gaaagtgata acgcaattgt gactaactgt tttggtcata ttatccagtc acaaccgccg
    39541 gaaaactata atcctgaata caaagcctgg aaggttgaaa cgcttccttt acgtctttat
    39601 cccgtgaagt atcagcctgt tgaaagtgcc gcaaaacagg ttaaaacgat tctcgaactt
    39661 atcagacgtg gagacgtgac tgaaattgtt cacgctggcg atcctgatga tgagggacag
    39721 ctacttgttg atgaagtcct ggaatatgca ggaaacacaa aacccgtgaa gcgcgttctg
    39781 ataaacgaca acacgcttcc ggcagtgaaa aaggcactgg caaatcttaa agataatcgt
    39841 gatttcaaag ggctttacct taaggcgctg gcgcgttcag ttgccgatgc cgtctatggc
    39901 ttctccatga cgcgtgctta caccattcct gcaaaagcca gaggatatca gggcgttctg
    39961 tctgtcgggc gcgtccagac gcccgttctt ggcctgattg tgaatcgtac ccgtgctaac
    40021 cagaaccata aatccagttt ttactacacc atgaccggag tctttcagcg tggtgctgat
    40081 gttctcaggg cgaactggaa accaggggaa tttgctccgc tgacagatcg taaattgctt
    40141 gataaggcat gggcaaacga aacggcggca tctcttgcgg gaaaaccagc caccgttgaa
    40201 gcagcagcaa ctgatgataa aaaaactgcc gcaccgttgc cgtttaatct ggtcaggctc
    40261 cagcaataca tgaacaaaaa gttcaaaatg acagcgcaaa aaacgctgga tgttacgcaa
    40321 caactacgcg aaaaatacaa agcgatcact tataaccgct ctgattgctc atatctttct
    40381 gatgaacaat tcagcgaagc gccacaggtt atcgatgccc tgaaatcagt atttcctcag
    40441 tcgctggata ttgattccgc acgtaaaagc aaggcgttta acagtgcaaa ggtgactgca
    40501 catactgcga taatcccgac agccagtgtg cctgatgtta atgcactcag caccgacgag
    40561 cgcaatgttt accttgcgat cgcacaacac tatcttgttc agttcatgcc tgaaaaagca
    40621 taccaggaag tatcggttgc cattcagtgt ggtgatgagt cgttctatgc ccgtgccaga
    40681 aaaacaactg acagcggatt tgaggcattt cttggtgcgg aaaccacaga cgaaggtgaa
    40741 tcagaagata acgatgattc cgcttttgaa ctgctctgta aaattcgcac aggagaaaca
    40801 ctgacgacaa aagaagttgt agttaatgag aagaaaacga caccgccgcc gttattcacc
    40861 gaagcctcct tgcttgctgc gcttgttcgc gtcgcggatt ttgtcactga cccaacgatt
    40921 aaaaaattgc tgaaggataa agataaagac aaaaaagatg aacatggcgg tattggtaca
    40981 ccagctaccc gagcagccat tctggaaact ctgaagaaaa gaaactatat cacactcgaa
    41041 aaagggaaac ttattccgac tgataccgga tgtgcgctta ttgataccct gccaggtata
    41101 gcggttaatc ctgatatgac ggcattatgg tctgaaaagc agacagccat tgaaaatggc
    41161 gagctgacgg ttgaacagtt tattaatgaa ctgtacagtg aactgacagg catgatttct
    41221 gatgttgacc tgggcgagat gaagattgaa cccgcagcgc cagcaggaca atctcaacgc
    41281 ctgaatgctc cctgcccttc ctgtggtaag cagattgcta tcagaccaaa aggttatttc
    41341 tgtacaggat gtgaatttaa aatctggagt gagttttctg gtaagaaaat cacccaggca
    41401 caggcagaaa aacttgttaa atcaggaaaa accgatttga ttaagggatt taaaaagaaa
    41461 agtggtggaa cgtatgatac agttcttgtt cttgaggata agaaaacagg gaagctgggt
    41521 tttccggcaa ggactaagaa gtgaaaacaa agcaggaatg gctttttcag ttaagaaaat
    41581 gtacatcaag agatactctt gaaaaagtta ttgagataaa ccgttacaaa ctgcctttat
    41641 cagaatcaga ggcattttat tctgccgcag atcatcgtcg cgcagaactg gttatgaata
    41701 aactgtatga taaggttcct tccggcgtct ggaagtacgt ccactaaaca agaggattaa
    41761 ttatgagcga actgactaaa gaagatgaat acggcattat cagccggact atgatgaata
    41821 ttcgttcatt gcgtgttttt gcccgtgaag ttgattttga gcagttgctt gaaatgcagg
    41881 aaaaactgaa cgttgtcatt gaagaacgtc gtgaagatgc tgaacgtgaa gcggctgaac
    41941 gccaggaact tgaagccaaa cgtcagcagg ccattgaata catcatatct ttaggtcttg
    42001 atcccgaatc actccttgct cctgtaacag cagatacagt aaaaaccagg cggaaagcca
    42061 aaggaggagt aagaaaggct aaataccgct ttaaggatga aaatggcgag atcagagaat
    42121 ggtctggtaa tggcaagcgt ccgcttgctt tacagaagct gcttgatgag ggccatttca
    42181 tggaagattt cctcattgac aaactgcaac ctgggcaggt tgaataaaat aatcgtgatg
    42241 ccgtcgcaaa cttgtttgcg acggcaaatg gaggggacag aacagccagc ggcgctggca
    42301 agaaatttta tcgtttgata aagagggaaa atgatgatca aatcaaaaaa agtagtggtt
    42361 atttttgttg ctttgagttc attcttgctg gcagggtgtg attcaccaaa agatgctaat
    42421 aagcaaaact ttgaaaaagc tattaatact cgactagaga aggaatgcat tactattagt
    42481 ccgctgggaa tgtttgatag taagccttat ccggttcagg tagctgtggc tcaggctaat
    42541 cgatatacat ctcaggaacg ggcagatgaa ataaattctc gacagttttc tgcgctggat
    42601 gtactggtca aagccaattt attaacagta aaagataccc
//
