LOCUS       NZ_CP104376             9294 bp    DNA     circular CON 02-OCT-2023
DEFINITION  Klebsiella pneumoniae strain 2021CK-01815 plasmid unnamed3, complete
            sequence.
ACCESSION   NZ_CP104376
VERSION     NZ_CP104376.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN24523856
            Assembly: GCF_025259665.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 9294)
  AUTHORS   Hergert,J., Casey,R., Wagner,J., Young,E.L. and Oakeson,K.F.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-SEP-2022) Utah Public Health Laboratory, Utah Public
            Health Laboratory Infectious Disease submission group, 4431 S 2700
            W, Salt Lake City, UT 84129, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. 0.5.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 243.0x
            Sequencing Technology :: Illumina MiSeq; Oxford Nanopore GridION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 10/02/2023 03:36:13
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,383
            CDSs (total)                      :: 5,262
            Genes (coding)                    :: 5,149
            CDSs (with protein)               :: 5,149
            Genes (RNA)                       :: 121
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 87
            ncRNAs                            :: 9
            Pseudo Genes (total)              :: 113
            CDSs (without protein)            :: 113
            Pseudo Genes (ambiguous residues) :: 0 of 113
            Pseudo Genes (frameshifted)       :: 45 of 113
            Pseudo Genes (incomplete)         :: 65 of 113
            Pseudo Genes (internal stop)      :: 24 of 113
            Pseudo Genes (multiple problems)  :: 18 of 113
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP104376.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..9294
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="2021CK-01815"
                     /isolation_source="Wound/Abscess"
                     /host="Homo sapiens"
                     /db_xref="taxon:573"
                     /plasmid="unnamed3"
                     /geo_loc_name="USA"
                     /collection_date="2021-12-07"
     gene            complement(1063..1212)
                     /locus_tag="N4558_RS26835"
                     /old_locus_tag="N4558_26830"
     CDS             complement(1063..1212)
                     /locus_tag="N4558_RS26835"
                     /old_locus_tag="N4558_26830"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891188.1"
                     /GO_component="GO:0019867 - outer membrane [Evidence IEA]"
                     /GO_process="GO:0019835 - cytolysis [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin release lysis protein"
                     /protein_id="WP_004152552.1"
                     /translation="MKKVKVVFLFILIFSGFLLVACQANYIRDVQGGTVAPSSSSELTG
                     IAVQ"
                     /name="colicin release lysis protein"
     gene            complement(1297..1554)
                     /locus_tag="N4558_RS26840"
                     /old_locus_tag="N4558_26835"
     CDS             complement(1297..1554)
                     /locus_tag="N4558_RS26840"
                     /old_locus_tag="N4558_26835"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin immunity family protein"
                     /protein_id="WP_004152553.1"
                     /translation="MGLKLHIHWFDKKTEEFKGGEYSKDFGDDGSVIESLGMPLKDNIN
                     NGWFDVEKSWVSILQPHFKNVIDISKFDYFVSFVYRDGNW"
                     /name="cloacin immunity family protein"
     gene            complement(1564..3249)
                     /locus_tag="N4558_RS26845"
                     /old_locus_tag="N4558_26840"
     CDS             complement(1564..3249)
                     /locus_tag="N4558_RS26845"
                     /old_locus_tag="N4558_26840"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin-like bacteriocin tRNase domain-containing
                     protein"
                     /protein_id="WP_004178188.1"
                     /translation="MSGGDGRGPGNSGLGHNGGQASGNVNGTSGKGGPSSGGGTDPNSG
                     PGWGTTHTPNGDIHNYNPGEFGNGGSKPGGNGGNSGNHSGSSGGGQSSATAMAFGLPAL
                     ATPGAEGLALSVSGDALSAAVADVLAALKGPFKFGLWGIAIYGVLPSEIAKDDPKMMSK
                     IVTSLPADTVTETPVSSLPLDQATVSVTKRVADIVKDERQHIAVVTGRPMSVPVVDAKP
                     TKRPGVFSVSIPGLPSLQVSVPKGVPAAKAPPKGIIAEKGDSRPAGFTAGGNSREAVIR
                     FPKESGQKPVYVSVTDVLTPAQVKQRLEEEKRRQQAWDAAHPEEGLKREYDKAKAELDA
                     EDKNIATLNSRIASTEKAIPGARAAVQEADKKVKEAEANKDDFVTYNPPHEYGSGWQDQ
                     VRYLDKDIQNQNEKLKAAQTSLNEMNESLSRDKAALSGAMESRKQKEKKAKDAENKLNE
                     EKKKPRKGTKDYGHDYFPDPKTEDIKGLGELKEGKPKTPKQGGGGKRARWYGDKKRKIY
                     EWDSQHGELEGYRASDGEHLGAFDPKTGKQVKGPDPKRNIKKYL"
                     /name="colicin-like bacteriocin tRNase domain-containing
                     protein"
     gene            3652..4071
                     /locus_tag="N4558_RS26850"
                     /old_locus_tag="N4558_26845"
     CDS             3652..4071
                     /locus_tag="N4558_RS26850"
                     /old_locus_tag="N4558_26845"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016247941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Exc2 family lipoprotein"
                     /protein_id="WP_001254601.1"
                     /translation="MRRSGSKLCLIAMITATATLTACAPKGSVEQHTRHYVYASDDGFD
                     PNFSTQKADTTRMMVPFFRQFWDMGAKDKATGKSRSDVQQRIQQFHSQEFLNSLQGTTQ
                     FAGTDYRSKDLTPKKSRLLADTISAVYLDGYEGRQ"
                     /name="Exc2 family lipoprotein"
     gene            4377..4640
                     /locus_tag="N4558_RS26855"
                     /old_locus_tag="N4558_26850"
     CDS             4377..4640
                     /locus_tag="N4558_RS26855"
                     /old_locus_tag="N4558_26850"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000072676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000072676.1"
                     /translation="MSNTTHYENANFLRELAESLPRILPEGGPDKAALLQRLANEELAQ
                     AEYEDQVRAKVTAARADTRPGMTTEQLRQRLHGRYQELRDAV"
                     /name="hypothetical protein"
     gene            4630..4929
                     /locus_tag="N4558_RS26860"
                     /old_locus_tag="N4558_26855"
     CDS             4630..4929
                     /locus_tag="N4558_RS26860"
                     /old_locus_tag="N4558_26855"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001146176.1"
                     /GO_function="GO:0008657 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) inhibitor activity
                     [Evidence IEA]; GO:0042803 - protein homodimerization
                     activity [Evidence IEA]"
                     /GO_process="GO:0030541 - plasmid partitioning [Evidence
                     IEA]; GO:0051290 - protein heterotetramerization [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_001146176.1"
                     /translation="MPYDVEWKQGAIEDVTTLFDYIAENSSLWDAQNVTDRVLAAADKL
                     ADFPRLYEVDSRYGEDVRRISLMGQHVLYDVDDQTRKVRVLAVVGQRQNPHIVL"
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            complement(4991..5368)
                     /locus_tag="N4558_RS26865"
                     /old_locus_tag="N4558_26860"
     CDS             complement(4991..5368)
                     /locus_tag="N4558_RS26865"
                     /old_locus_tag="N4558_26860"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000312627.1"
                     /translation="MAWVTVRQATELTGKARSSLYRDMAKGRVSYRTEADGGRVVDTSE
                     LIRVYGELRQDETHERDELRLSGETEKMASDALIAEIKALREEVAGLRQEMQSMRLLEH
                     KPETAETPAGTPRRWWPWGKR"
                     /name="hypothetical protein"
     gene            5437..5616
                     /locus_tag="N4558_RS26870"
                     /old_locus_tag="N4558_26865"
     CDS             5437..5616
                     /locus_tag="N4558_RS26870"
                     /old_locus_tag="N4558_26865"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rop family plasmid primer RNA-binding protein"
                     /protein_id="WP_000165971.1"
                     /translation="MTKQEKTALNMAKFIKEQSLLLLDKLNELDMDTPADMCERLHEDA
                     ETLWQVMRDKLGEE"
                     /name="Rop family plasmid primer RNA-binding protein"
     gene            complement(5644..6174)
                     /locus_tag="N4558_RS26875"
                     /old_locus_tag="N4558_26870"
     CDS             complement(5644..6174)
                     /locus_tag="N4558_RS26875"
                     /old_locus_tag="N4558_26870"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_004153058.1"
                     /translation="MALYMVFIEDAEDRNGERCIMPTSEHLEDMVVLAWQTGAYVFCFV
                     DRAQHLAMMKSIGMYDERLNSDEKATYFFTGKNPQWERNKPTGMKLCDYLYRKVERFAI
                     ENGVQVVDAGKCSPEQINAMIDVVSERHGESAVNEKLKAELMREYNSRYFNVPVPELPE
                     DKPARRWWPFGKK"
                     /name="hypothetical protein"
     gene            complement(6181..6912)
                     /locus_tag="N4558_RS26880"
                     /old_locus_tag="N4558_26875"
     CDS             complement(6181..6912)
                     /locus_tag="N4558_RS26880"
                     /old_locus_tag="N4558_26875"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobC family replication-relaxation protein"
                     /protein_id="WP_004152551.1"
                     /translation="MALELYNVSHAKRQARNAEKTRLTLRWLREELCSTAELVARRLGI
                     AAVQPVYRFLDSLVAKGLLVRTKYPVDGRQVSVWGLTPHGVAFSFDEDEPLADVIPFQP
                     SRVSAAHLPHRLAVQSLRLDMEARGATGWRILHRLSLKGMKVPDALAELDGKTVAFEVE
                     RTVKSRRRYQEVVSGYLFNRKANGIDEIWYICPDRATQVRVQRAILSVDEIVNPQTGEA
                     RKTAELDRERLFACFKFMTTE"
                     /name="MobC family replication-relaxation protein"
     gene            complement(6912..8876)
                     /locus_tag="N4558_RS26885"
                     /old_locus_tag="N4558_26880"
     CDS             complement(6912..8876)
                     /locus_tag="N4558_RS26885"
                     /old_locus_tag="N4558_26880"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004178196.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TraM recognition domain-containing protein"
                     /protein_id="WP_004178196.1"
                     /translation="MFNTDSLAWKWHIPELARQIYPWVSWLYQEYYGLAGAFLVIGLFF
                     GLAELWAGRMRFVGLSHKERREYADRYKRDNKRPAPFSVLASLDSPGRMVRARRHVWNY
                     AYWLTGAAGLALLGGLVVAVFIESWGETVLRPDLYANADYYLLQPANLFGIAWCAGGLA
                     VGIVLARLLAFLLLDGHFAAADEAVNAKLNQESRRSSQRTGEMTDVRHLHFGEPVPVNA
                     LADFSSEQARQEQAVFLGKDEQGKPVLVPRDTWRKTNIQILGLPGSGKSVMATNALIRC
                     VRDFGDAVVYFDPKGDAWAPHVFRAHCPDFTLLDLRPGKPAQLNLFRDLDQYALKNLLI
                     AGLNLGETGDVADHYRISEQKAAKLIAEQFPQGANIQQVLAAAYALPEALKKDVKGLIT
                     RLENVADLSVLQTDSGIDVAGIINGGGCLYVIGSMDDEAVIRVQKMLFARCAQIIIARD
                     EFREWPHVSVMLDEIKYLLSKYVLNALGTLRSRDCNLLLAHQSLGDFGQCGQDLPAEFV
                     KTTVLDNTPIRWFYRAASLESAQWAAGQTGEIRVDVERRRASREAGNVEHISGDSFIQK
                     EARPLFDVNTLQHLPDGFAVMTGLGVARMAFSSPLRVERREIPLQRFPVLAKTDPLAEF
                     RPPADGGGPKADDDFAGIY"
                     /name="TraM recognition domain-containing protein"
     BGC             1..8249
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          382..960
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="95.361"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(6185..6912)
                     /name="MOBC"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="1.32e-150"
ORIGIN
        1 aagaggggga gagaccgtgc gtcggtggcg tccagccagc gtaagcaggg gatatccccc
       61 tgaggtcagc cacgccctcg cggggatgac ctgtatttct ccgtaaggag aaaaaagcaa
      121 cagagatagg ttaacgtaaa atgttcagcg aaaaaccgat atgattcacc tatcctggta
      181 atttattatc agggaatata aagacttaat caggggacaa tatgccacat cagcgcgtcc
      241 ggtgtccgtc ttgtaggtgc cggggaaatt gcgcctcctc gctcactcgg tcgctacgct
      301 ccggccgtga gactgcggcg ggcgctgcgg acacatgcaa agttacccac agattccgtg
      361 aataagcagg ggactaacat gtgaggcaaa acggcaaggc cacgcaggtg gcgtttttcc
      421 ataggctccg ccctcctgac tgagttcaca taaacagacg ctttttcggt gcatctgtgg
      481 gagccggtgg ctcaaccatg aatcagtcag gagtggcgaa acccgacagg acttaaagat
      541 catcaccgtt tccgatgaat cgctccctct tgcgctctcc tgttccaacc ctgccgtttc
      601 ccggatacct gttccgcctt tctcccttgc gggaagtgtg gcgctttctc atagctcaca
      661 ctctggtatc tcggctcggt gtaggtcgtt cgctccaagc tgggctgtaa gcaagaaccc
      721 cccgttcagc ccgactgctg cgccttatcc ggtaactgtt cacttgagtc caacccggaa
      781 aagcacgcaa aacgccactg gcagcagcca ttggtaactg ggagttcgca gaggatttgt
      841 ttagctaaac acgcggttgc tcttgaagtg tgcgccaaag tccggctaca ctggaaggac
      901 agatttggtt gctgtgctct gcgaaagcca gttaccacgg ttaagcagtt ccccaactga
      961 cttaaccttc gatcaaacca cctccccagg tggttttttc gtttacaggg caaaagatta
     1021 cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctactgaa ccgcgatccc
     1081 cgtcagttca gaggaggacg atggtgccac cgttccaccc tgaacatccc ggatatagtt
     1141 tgcctgacat gcgaccagaa gaaagcctga aaaaatcaat ataaaaagaa aaacaacctt
     1201 tacctttttc atataccttc cctgtattta aaaaccccgg tattcatccc tgaacaccgg
     1261 aagtctgtat ttcaaatcat ccttgataac ttttgcttac cagttaccat cccggtaaac
     1321 aaaggataca aagtaatcaa atttactaat atcgattaca tttttaaagt gtggctgtaa
     1381 tatcgaaacc catgattttt caacatcaaa ccaaccatta ttaatattat cctttaaagg
     1441 catccccaga ctttcaatga cagaaccatc atcaccgaag tcttttgagt attcaccacc
     1501 tttaaactct tcggttttct tatcaaacca atgaatatgt aatttaagcc ccatatttac
     1561 ctcttaaaga tattttttaa tgtttcgttt tggatccggc cctttaacct gcttacccgt
     1621 ttttggatcg aatgccccga ggtgttcgcc atcactggcg cggtaccctt caagctcacc
     1681 gtgctgggaa tcccattcat aaattttacg ctttttatca ccataccatc gggcccgctt
     1741 accaccacca ccttgtttag gggttttagg tttaccctct ttcaactctc ccaacccctt
     1801 aatatcttca gtcttgggat caggaaaata atcatggccg taatctttag ttcccttacg
     1861 aggttttttc ttttcctcat ttaatttatt ttctgcatcc ttcgcttttt tctccttttg
     1921 tttccggctc tccatcgccc cggaaagcgc agccttatcc ctggataagg attcattcat
     1981 ttcgtttaaa gatgtctggg cagcttttaa tttctcattc tgattctgaa tatccttatc
     2041 aagatagcga acctgatcct gccacccgga gccatattca tgaggcgggt tataagtcac
     2101 aaaatcatct ttatttgcct ctgcctcttt taccttttta tcggcttcct gaacagcagc
     2161 ccttgcaccg gggatcgcct tctctgtcga tgcaatgcga ctgtttaagg tcgcaatatt
     2221 tttatcttca gcatccagct cagctttcgc tttatcatac tctcttttca gcccctcttc
     2281 cgggtgagca gcgtcccatg cctgctggcg acgcttttct tcctccagac gctgttttac
     2341 ctgtgccgga gtaagaacat ccgtcaccga cacatagacc ggtttctgtc cgctctcttt
     2401 cgggaaacga ataacggctt cacgggagtt accaccggcc gtaaaaccag ccggacgtga
     2461 atcacctttt tcagcaataa tgccttttgg cggggctttc gcggccggaa cacctttagg
     2521 tacgctcacc tgcagagacg ggagacccgg aatcgacaca ctgaataccc ccggacgttt
     2581 tgtcggtttc gcatccacca caggaacact cattggccgg ccggtgacaa ccgcaatatg
     2641 ctgccgctcg tccttcacaa tatccgccac acgtttagtg acgctgaccg tcgcctggtc
     2701 cagcggcagg gagctgaccg gcgtctccgt taccgtgtct gccggcaatg acgtcacgat
     2761 ttttgacatc attttcggat catcttttgc tatctcagaa ggcagcactc cgtaaatcgc
     2821 aatcccccac agaccaaact taaacggacc tttcagggca gccagcacat cagcaacagc
     2881 ggccgacaac gcatcgccgg aaacggataa agccagtcct tcagcccccg gagtggccaa
     2941 ggcaggcaga ccgaaggcca tcgcggtggc cgaagactgt ccgccaccag agctcccgct
     3001 atgattgccg ctgttaccgc cattaccacc gggtttactc ccgccgttac caaactcccc
     3061 cgggttatag ttatgaatat ccccgttagg tgtatgcgtc gtaccccagc ccggcccgct
     3121 gtttggatcc gtaccaccac ctgatgaagg gccaccttta cctgatgtac cgttcacatt
     3181 cccactggcc tgaccaccat tgtgtcccag acctgaatta cccggacctc gtccgtctcc
     3241 gccactcata tacttttcct ctttgacttt taaaacaata aactaaaata aaatactgta
     3301 catataacca ctggttttat atacagtata aaaattacgc tgccttgttt ttcatgtcaa
     3361 gtctgtaaat ttgcgttttt gtgaaaatga tcaaaaaaac agccactcac accatgcgca
     3421 atcccctcca gatgcaacaa aaaccagcac aaacggcgcc gttctccggc ctcagtatgt
     3481 tttactgaaa tcattatatg agataccaga aagccccctc cgggacagga aaagaaacgg
     3541 ggggtctggt tcgggttgtt cggtcactga acacggtcag aaactgatga taagatagcc
     3601 tgcggatata taactcaatg agaaaaaaga attaaaggta aggagacgct catgagacgt
     3661 tccggcagca aactgtgtct tatcgccatg ataacagcga cagcaactct cactgcctgt
     3721 gctccaaagg gcagcgtgga acagcatacc cggcattacg tatatgcttc agatgacggt
     3781 tttgatccca atttttccac ccagaaagct gacacaacac gaatgatggt gccttttttc
     3841 cggcagttct gggatatggg cgcaaaggat aaagcgaccg gaaaatcacg gagtgatgtg
     3901 cagcaacgca ttcagcagtt tcacagtcag gaatttttaa actcactcca aggcacaaca
     3961 caatttgcgg gtaccgatta ccgcagcaaa gacctcacac cgaaaaaatc aaggctactg
     4021 gctgacacca tttcagctgt ttatctcgat ggctatgaag gcagacagta agtggattta
     4081 ccataacgcg tcattacgcg caccgctcag acgggctcag ggcgtttccg gcggctacgg
     4141 gataaaacag gcaacaaccc ccccggaaaa ctgccggaaa cgcgcccgat aaattttatc
     4201 ctaatgcatg cctatgcacg caactgcatg gcatatgttt tgacgtaaaa tggatgccgt
     4261 aagccctttt ttaccgactt tctgcttcat cagcctgact gacacgacca tattctttca
     4321 gaccgccccc tgctaaactt ccttcatatt gccgcattaa cccgggaggc tccgcaatga
     4381 gcaacactac acactacgaa aacgccaact ttcttcggga actggctgaa agcctgcccc
     4441 gcatactgcc ggaaggtggc ccggacaaag ctgcgctgtt gcagcgactg gctaacgaag
     4501 aactggccca ggcagagtat gaagatcagg ttcgcgccaa agtgaccgcc gcccgtgctg
     4561 acacgcgtcc gggtatgacc acggaacaac tccgccagcg cctgcatggc cgttatcagg
     4621 aactgcgcga tgccgtatga cgtggaatgg aagcagggag ccatcgagga tgtaacgacg
     4681 ctgtttgact atatcgcgga aaattcatcc ctgtgggatg cgcagaacgt taccgaccgg
     4741 gttctcgctg cggcggacaa actggccgac ttcccgcgac tctatgaagt ggactcacgc
     4801 tatggcgagg acgttcgccg gatcagtctg atgggacagc atgtcctcta tgatgttgat
     4861 gaccagacca gaaaagtccg ggttctggcc gtggtcggcc agcgccagaa tccccatatt
     4921 gttctctaat aaccggtgac ggggacgcaa ttcattgcgt ggccgtcgcc ggttggacaa
     4981 gcacagcgcg tcagcgtttt ccccacggcc accaccggcg cggtgttccg gccggggtct
     5041 ctgctgtctc cggtttgtgt tccagcagtc tcatggactg catttcctgc cgtagcccgg
     5101 ccacctcctc cctgagtgct tttatctccg cgatcaacgc gtcggaggcc attttttcag
     5161 tctcacccga cagtctcaac tcgtcccgct cgtgagtctc atcctgtctt aactcaccgt
     5221 acacccggat aagctcgctg gtatccacca cccggccgcc atcagcttcc gtacggtatg
     5281 atacgcggcc tttcgccata tcccgataca gggaacttcg ggctttaccc gtcagttccg
     5341 tcgcctgtct caccgtcacc cacgccattg tctcaccccg ctatttttga gacagtatac
     5401 ctgacaggcg cacaccatgc ccggaaggaa agaatcatga caaaacagga aaaaacagcc
     5461 ctcaatatgg ctaaatttat taaggagcag tcgctgctat tgctcgataa actgaatgag
     5521 ctggatatgg ataccccggc cgacatgtgc gagcggctac acgaggatgc ggaaacactc
     5581 tggcaggtga tgcgggataa gctcggggag gaataacagc accggcatgg ccggtgctgg
     5641 catttatttt ttgccgaacg gccaccaccg gcgggcaggt ttgtcctccg gcagttcagg
     5701 taccggcacg ttaaaatagc ggctgttata ttcccgcatc agctccgctt tcagcttctc
     5761 gttcaccgcg ctttccccgt gccgctcact caccacgtca atcatcgcgt taatctgctc
     5821 cggtgagcac ttcccggcat caaccacctg cacaccgttc tcgatggcga accgctccac
     5881 cttgcgatag aggtaatcac acagcttcat tcctgtgggt ttgttccgtt cccattgcgg
     5941 atttttacca gtgaaaaagt acgtggcttt ttcgtcgctg ttgagccgct cgtcatacat
     6001 cccgatggat ttcatcatcg ccagatgctg ggcccggtcg acaaaacaga aaacatacgc
     6061 cccggtctgc caggcgagca ccaccatatc ttccagatgc tcgctggtcg gcatgatgca
     6121 gcgctcgccg ttccggtcct ccgcgtcttc aataaatacc atgtacagcg ccataatccc
     6181 tcactccgtt gtcataaatt taaagcacgc aaacaaccgt tcacgatcca gctctgccgt
     6241 tttgcgggcc tcgccggtct gtgggttcac gatttcatcc accgacagga ttgcccgctg
     6301 caccctgacc tgcgtcgccc ggtccgggca gatgtaccag atttcatcga tgccgttagc
     6361 tttgcggttg aacagatacc cggacaccac ttcctgatac cggcgacggc tcttgacggt
     6421 gcgctccacc tcaaacgcca ccgttttacc gtccagctcc gccagggcgt ccggcacttt
     6481 catgccttta agactcagac ggtgcagaat gcgccagccg gtggcccctc tggcttccat
     6541 atcaaggcgc agggattgca cggccagccg gtgcggcaga tgtgctgccg acacccttga
     6601 cggctgaaac ggaataacat ccgccagcgg ttcgtcctcg tcgaacgaga acgccacgcc
     6661 atgcggcgtc agcccccaca cgctgacctg acggccgtcc accggatatt tggtccggac
     6721 cagcagccct ttcgccacca ggctgtcgag gaagcggtag accggctgca ccgccgcaat
     6781 ccccagccgc cgcgcaacca gctccgccgt ggaacacagc tcttcccgca accagcgcag
     6841 ggtcagccgg gttttctccg cgttccgcgc ctgtcgtttc gcgtggctga cgttgtacag
     6901 ctccagcgcc atcagtaaat ccccgcaaaa tcatcatccg ctttcggccc gccgccgtcg
     6961 gccgggggcc ggaactccgc caggggatcg gttttcgcca gcaccgggaa acgctgcaac
     7021 gggatttccc ggcgctcaac ccgcagcgga ctgctgaacg ccatccgggc cacacccagc
     7081 ccggtcatga ccgcgaaccc gtccggcagg tgttgcaggg tgttcacgtc aaacagcggc
     7141 cgcgcctcct tctggatgaa gctgtccccg ctgatatgct ccacgttccc cgcctcccgg
     7201 ctggcacggc ggcgctccac gtccaccctg atttccccgg tctgccccgc cgcccactgc
     7261 gcggactcca ggctggccgc ccggtaaaac cagcggatcg gcgtgttatc cagtaccgtg
     7321 gttttcacaa attcagcggg cagatcctgc ccgcactgcc cgaaatcgcc cagcgactgg
     7381 tgcgcgagca acagattgca gtcccggctg cgcagcgtcc ccagtgcgtt cagtacatac
     7441 ttcgacagca gatatttaat ttcatcgagc atcacgctga cgtgtggcca ctcccggaac
     7501 tcgtcccgcg caatgatgat ttgcgcgcag cgggcaaaca gcattttttg cacacggatc
     7561 accgcctcgt cgtccatcga gccgataacg tacaggcagc cgccgccgtt gataatcccc
     7621 gccacatcga tgccactgtc cgtctgcagg acgctcaggt cagcgacgtt ttccagccta
     7681 gtgatcaacc ccttcacgtc ctttttcagg gcctccggca gcgcgtacgc cgccgccagc
     7741 acctgctgaa tgtttgcccc ctgcggaaac tgctccgcaa tcagcttcgc cgctttctgc
     7801 tcgctgatgc ggtagtggtc cgccacgtcg ccggtctcgc ccaggttaag cccggcaatc
     7861 agcaggtttt tcagcgcgta ctggtcgaga tcgcggaaca gattcagctg cgccggtttc
     7921 cccggccgca gatccagcag ggtgaagtcc ggacagtgcg cccggaagac gtgcggcgcc
     7981 catgcgtccc ctttggggtc gaagtacacc accgcgtccc cgaaatcgcg tacgcagcga
     8041 atgagcgcgt tggtggccat cacgctcttg ccgctcccgg gcaggccgag gatctgaatg
     8101 ttggtcttgc gccaggtatc acgcggaacc agcaccggct tgccctgctc atccttaccc
     8161 agaaacaccg cctgctcctg ccgggcctgc tccgaggaaa aatcggccag cgcattaacc
     8221 ggtaccggct ccccgaaatg caggtggcgc acgtcggtca tctctcctgt ccgctggctg
     8281 ctgcgccggc tctcctgatt cagtttcgcg ttcaccgcct cgtcagcagc cgcaaaatga
     8341 ccgtcaagca gcaggaacgc cagcagccgc gccaacacaa tcccgacagc cagcccgccc
     8401 gcgcaccagg caatcccgaa caggttagcc ggctgcagca ggtaataatc tgcgtttgcg
     8461 tagaggtccg gacgcaggac ggtttctccc cagctctcga taaacacggc gacaaccagc
     8521 ccccccagaa gggccagacc ggccgcgccg gtcagccagt acgcgtagtt ccagacatgt
     8581 cgacgtgccc tgaccatccg cccgggcgaa tccagcgagg ccagcaccga aaatggcgct
     8641 ggccgtttat tatcgcgctt atagcgatcg gcatactccc gtcgctcctt atgactcagc
     8701 cccacaaaac gcatccgtcc ggcccaaagt tcagccagac cgaaaaacag gccgataact
     8761 aggaaagccc cggccagacc gtaatactcc tggtacagcc agctgaccca cggataaatc
     8821 tgccgggcca gctccggaat gtgccacttc caggcaagcg aatccgtatt aaacatgttc
     8881 tctctccttc agacgatggt ttgccggcgt gatgtgcagc ccccgctgca caagccgcgg
     8941 acatgcccca aggcatggcg gcggcggtca cgtccgtggt gattgcgttc agctttcacc
     9001 acggaggcca gcctctttcc gccccatgcg gaaaaggcgc agccccggag gaacaacgag
     9061 cacgccccag cgtgtgagag gaaaaggcgg caccccagtg cggtcttttc cggtgttccg
     9121 gcccccgtca gagttcgcca tagcgagcgg ctgaccaccc gcaaaatcag gagcagcttt
     9181 gctgcttcgc caggtgcgtc cagcaccgtg gatttttgtg ggtggtcagg cgtgagcctg
     9241 acgggggccg ggtgaatttc tggcgtggcc ggcgtccagc cggacggagc caga
//
