LOCUS       NZ_CP103861            27068 bp    DNA     circular CON 29-SEP-2023
DEFINITION  Staphylococcus aureus strain R3-8 plasmid unnamed, complete
            sequence.
ACCESSION   NZ_CP103861
VERSION     NZ_CP103861.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN30550580
            Assembly: GCF_025232045.1
KEYWORDS    RefSeq.
SOURCE      Staphylococcus aureus
  ORGANISM  Staphylococcus aureus
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 27068)
  AUTHORS   Aung,M.S., Urushibara,N. and Kobayashi,N.
  TITLE     Molecular characterization of a USA300-like MRSA clinical isolate in
            Japan
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 27068)
  AUTHORS   Aung,M.S., Urushibara,N. and Kobayashi,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-AUG-2022) Hygiene, Sapporo Medical University, S-1,
            W-17, Chuoku, Sapporo 060-8556, Japan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Flye v. 2.9
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Reference-guided Assembly         :: R3-8
            Genome Coverage                   :: 2898000.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 09/29/2023 07:29:42
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,962
            CDSs (total)                      :: 2,880
            Genes (coding)                    :: 2,792
            CDSs (with protein)               :: 2,792
            Genes (RNA)                       :: 82
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 88
            CDSs (without protein)            :: 88
            Pseudo Genes (ambiguous residues) :: 0 of 88
            Pseudo Genes (frameshifted)       :: 48 of 88
            Pseudo Genes (incomplete)         :: 42 of 88
            Pseudo Genes (internal stop)      :: 18 of 88
            Pseudo Genes (multiple problems)  :: 19 of 88
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP103861.1.
            Bacteria and source DNA available from Meiji Soe Aung.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..27068
                     /organism="Staphylococcus aureus"
                     /mol_type="genomic DNA"
                     /strain="R3-8"
                     /isolation_source="venous blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:1280"
                     /plasmid="unnamed"
                     /geo_loc_name="Japan: Hokkaido"
                     /lat_lon="43.01 N 141.4 E"
                     /collection_date="2021-01-31"
                     /collected_by="Meiji Soe Aung"
                     /genotype="ST8"
     gene            complement(join(26835..27068,1..441))
                     /locus_tag="NYR13_RS14645"
                     /old_locus_tag="NYR13_14645"
     CDS             complement(join(26835..27068,1..441))
                     /locus_tag="NYR13_RS14645"
                     /old_locus_tag="NYR13_14645"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS257 family transposase"
                     /protein_id="WP_001105991.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TVYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDAEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVITDQAPSTKVAMVKVIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6-like element IS257 family transposase"
     gene            703..888
                     /locus_tag="NYR13_RS14650"
                     /old_locus_tag="NYR13_14650"
     CDS             703..888
                     /locus_tag="NYR13_RS14650"
                     /old_locus_tag="NYR13_14650"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001037130.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001037130.1"
                     /translation="MNKLEKWSLVFIIFTFLSSLALLYFKYNFSSVMPVLSLSILTILI
                     LLTSIITVVSVNDEDT"
                     /name="hypothetical protein"
     gene            complement(1111..1689)
                     /locus_tag="NYR13_RS14655"
                     /old_locus_tag="NYR13_14655"
     CDS             complement(1111..1689)
                     /locus_tag="NYR13_RS14655"
                     /old_locus_tag="NYR13_14655"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000690624.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_000690637.1"
                     /translation="MKIGYARVSTGLQNLNLQEDRLNTYGCEKIFNDHMSGSKSKRPGL
                     DKAIEFARSGDTIVVWRLDRLGRNMEDLITLVNELNERGVSFHSLEENITMDKSSSTGQ
                     LLFHLFAAFAEFERNLILERSSAGRIAARARGRYGGRPEKLNKQDLNLLKTLYDNGTPI
                     KTIAEQWQVSRTTIYRYLNKLEAKENKNK"
                     /name="recombinase family protein"
     gene            complement(1953..2333)
                     /gene="blaI"
                     /locus_tag="NYR13_RS14660"
                     /old_locus_tag="NYR13_14660"
     ARG             complement(1957..2333)
                     /name="blaI"
                     /gene="blaI"
                     /gene_name="penicillinase repressor BlaI"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="98.41"
                     /coverage="100.0"
     gene            complement(2323..4080)
                     /gene="blaR1"
                     /locus_tag="NYR13_RS14665"
                     /old_locus_tag="NYR13_14665"
     ARG             complement(2327..4080)
                     /name="blaR1"
                     /gene="blaR1"
                     /gene_name="beta-lactam sensor/signal transducer BlaR1"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="95.38"
                     /coverage="100.0"
     gene            4187..5032
                     /gene="blaZ"
                     /locus_tag="NYR13_RS14670"
                     /old_locus_tag="NYR13_14670"
     ARG             4188..5029
                     /name="blaZ"
                     /gene="blaZ"
                     /gene_name="penicillin-hydrolyzing class A beta-lactamase
                     BlaZ"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(5558..5977)
                     /locus_tag="NYR13_RS14675"
                     /old_locus_tag="NYR13_14675"
     CDS             complement(5558..5977)
                     /locus_tag="NYR13_RS14675"
                     /old_locus_tag="NYR13_14675"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000418034.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_000418035.1"
                     /translation="MELDNCINYLLSTSQNRVFKHFKSLLSPYNITPAEYGVLNCLINS
                     NLNTPKAIGNTLNLEPSTISGILDKMSKKDLITRQTDNENRRTVLINSTNKAKDLWPTL
                     EKKAYQLNNHYFANLTNEETVVFKKILLKINKTTF"
                     /name="MarR family transcriptional regulator"
     gene            6101..7072
                     /locus_tag="NYR13_RS14680"
                     /old_locus_tag="NYR13_14680"
     CDS             6101..7072
                     /locus_tag="NYR13_RS14680"
                     /old_locus_tag="NYR13_14680"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000481285.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="oxidoreductase"
                     /protein_id="WP_000481279.1"
                     /translation="MFNAVVVRKSASNVSYKVEKVDESHLSKGDVLVKVVYSSINYKDM
                     LALQYKGGVIRDYPMIPGIDFAGIVESSSNDKFKEGDNVLVTGYDVGVTHTGGFSEYAQ
                     VPGEWIVPIPQEMSIKESMVYGTAGFTAALSIFELEKYGMNIKSQPEILVSGATGGVGS
                     VAIQILHKIGYENITAIVRKEKQIEIAKKLGAKQVIIIEDDNKPLKKGIFDYFLDTVGS
                     NVTLYGLKRLNYQGVATVCGNVAGNSLNANILPFILRGIKLIGIDSVYVDHNIREDIWS
                     KLANEWNIGNSLLYNEIGFEEFYKTIDQLLKGQHLGRTILKV"
                     /name="oxidoreductase"
     gene            complement(7244..7336)
                     /locus_tag="NYR13_RS14685"
                     /old_locus_tag="NYR13_14685"
     CDS             complement(7244..7336)
                     /locus_tag="NYR13_RS14685"
                     /old_locus_tag="NYR13_14685"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002495832.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="WP_001791613.1"
                     /translation="MLIIFVHIIAPVISGCAVAYYTYWLSKRNK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            complement(7493..7840)
                     /locus_tag="NYR13_RS14690"
                     /old_locus_tag="NYR13_14690"
     CDS             complement(7493..7840)
                     /locus_tag="NYR13_RS14690"
                     /old_locus_tag="NYR13_14690"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020366422.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003700 - DNA-binding transcription factor activity
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_000119690.1"
                     /translation="MSYENTCDVICVHEDKVNNALSFLEDDKSKKLLNILEKICDEKKL
                     KIILSLIKEDELCVCDISLILKMSVASTSHHLRLLYKNEVLDFYKDGKMAYYFIKDDEI
                     REFFSKNHEGF"
                     /name="metalloregulator ArsR/SmtB family transcription
                     factor"
     gene            complement(7859..8476)
                     /gene="cadD"
                     /locus_tag="NYR13_RS14695"
                     /old_locus_tag="NYR13_14695"
     ARG             complement(7863..8476)
                     /name="cadD"
                     /gene="cadD"
                     /gene_name="cadmium resistance transporter CadD"
                     /tool="amrfinderplus"
                     /drug_class="CADMIUM"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(9592..9786)
                     /locus_tag="NYR13_RS14700"
                     /old_locus_tag="NYR13_14700"
     CDS             complement(9592..9786)
                     /locus_tag="NYR13_RS14700"
                     /old_locus_tag="NYR13_14700"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001004925.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001004925.1"
                     /translation="MNENLEKYIKSLPLLGLLISILLIVLFFFILDVDEDLFVVFLYCL
                     LPLIVNLSIYGFYVFVKRK"
                     /name="hypothetical protein"
     gene            9896..10588
                     /locus_tag="NYR13_RS14705"
                     /old_locus_tag="NYR13_14705"
     CDS             9896..10588
                     /locus_tag="NYR13_RS14705"
                     /old_locus_tag="NYR13_14705"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000691527.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="putative immunity/bacteriocin fusion bifunctional
                     protein"
                     /protein_id="WP_000691527.1"
                     /translation="MKIIKLFSIISLFLLVFSANFSNAYANEEQKSSLLENQKEKLKSK
                     NIEVSQMTKKEISFLEQLQNKNEDMQKFEKQMKKEGFKKIKLEDKNSKLKYLATEANDK
                     NAYGYIANNAYKNEKTKEIVVSETIYDNYNKKITKFIAEKRSMTENKEGKILINKNYVE
                     YKAEKVDKNRPVTYAGFKWNGKAFACSMAGLYACAHYCGVWAIVNPIAGGVCEAVCGTA
                     FAAGCSVG"
                     /name="putative immunity/bacteriocin fusion bifunctional
                     protein"
     gene            complement(10756..10905)
                     /locus_tag="NYR13_RS14710"
                     /old_locus_tag="NYR13_14710"
     CDS             complement(10756..10905)
                     /locus_tag="NYR13_RS14710"
                     /old_locus_tag="NYR13_14710"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000695367.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000695366.1"
                     /translation="MKIKTFATFTHRQLDKQVNRFLKNDIHVLEIQTHSNWLYISAIVF
                     YEDK"
                     /name="hypothetical protein"
     gene            complement(11452..>11741)
                     /locus_tag="NYR13_RS14715"
                     /old_locus_tag="NYR13_14715"
                     /pseudo=""
     CDS             complement(11452..>11741)
                     /locus_tag="NYR13_RS14715"
                     /old_locus_tag="NYR13_14715"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009384749.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="protein rep"
                     /name="protein rep"
     gene            complement(11761..12744)
                     /locus_tag="NYR13_RS14720"
                     /old_locus_tag="NYR13_14720"
     CDS             complement(11761..12744)
                     /locus_tag="NYR13_RS14720"
                     /old_locus_tag="NYR13_14720"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001181101.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /protein_id="WP_001181107.1"
                     /translation="MQNQYFTVQENYKERFYQIPKVFFTSENYKNLTNDMKIAYAILRD
                     RLNLSIKNSWVDEDGNIYFVYSNEKLMEILNCKKEKLTKIKKGLENDGLLIQKRRGLNK
                     PNILYLMKPIVTERDIYKIEKEENDVEPYGEKEVRKSNVQKFENRTSRSSKIERPEVRK
                     SNTNDTDFNDIDFNDTENNDMNDLNDIKYKNEISNHSNHSNQFTHNFDDKEMLLQEFPE
                     QLTNYLLKYDYRDLEIIKAVILKAKKSFNSRHEDMHYMLEDIEDEILTSLKRLKKAIHD
                     RGVKGQKETIKSMQAYLMQTILTELEETHALYMRRKNMKQYNIFNQ"
                     /name="replication initiator protein A"
     gene            13170..13913
                     /locus_tag="NYR13_RS14725"
                     /old_locus_tag="NYR13_14725"
     CDS             13170..13913
                     /locus_tag="NYR13_RS14725"
                     /old_locus_tag="NYR13_14725"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000843735.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /protein_id="WP_000843732.1"
                     /translation="MKSVKKLSEELGVSKQTIFNNIKRLNIETIKQENTSFIKEDTDIE
                     KIIQRVNENKKKYGFESTTEDKQKKGSDNINFESKSDAQIVEILKNQIDTLNNQIEKQE
                     SRHETTIEFYRKELQERSKLLENQQVLALESNKKIQKLENQLEKEKHLNYPFDTSTNTR
                     QNVDAQEKTYTTNPVNINRDQEETKETEIQYKDISGSQSDESTQGEEAKKEDVPANLND
                     NDSDIEEKSEETEPKKGFWSRLFGS"
                     /name="DUF536 domain-containing protein"
     gene            complement(14140..14325)
                     /locus_tag="NYR13_RS14730"
                     /old_locus_tag="NYR13_14730"
     CDS             complement(14140..14325)
                     /locus_tag="NYR13_RS14730"
                     /old_locus_tag="NYR13_14730"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011276570.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_000797248.1"
                     /translation="MKNRIREYRKQKGISQETLSKELKVSRQTINAIENNKYDPTLTLA
                     FKLARLFDTTVDELFS"
                     /name="helix-turn-helix transcriptional regulator"
     gene            complement(14330..14668)
                     /locus_tag="NYR13_RS14735"
                     /old_locus_tag="NYR13_14735"
     CDS             complement(14330..14668)
                     /locus_tag="NYR13_RS14735"
                     /old_locus_tag="NYR13_14735"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001049146.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001049146.1"
                     /translation="MNLIPFIIILIFSCLWTAITNKYLPSETLDKKGQQDRYDERQRKM
                     FIEILAKSFIWIVYCMLFTLVLKFTGLSPSIEGSWFSQYPEIFFIIVALFLMLFNYYTT
                     NKKYTSKG"
                     /name="hypothetical protein"
     gene            complement(14914..15522)
                     /locus_tag="NYR13_RS14740"
                     /old_locus_tag="NYR13_14740"
     CDS             complement(14914..15522)
                     /locus_tag="NYR13_RS14740"
                     /old_locus_tag="NYR13_14740"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002474535.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_000583528.1"
                     /translation="MIIGYARVSSIDQNLERQLDNLKTFGVEKIFTEKQSGKSVENRPV
                     FQEALNFVRMGDRFVVESIDRLGRNYDEIIETVNYLKEKDVQLMITSLPMMNEVIGNPL
                     LDKFMKDLIIQILAMVSEQERNESKRRQAQGIQVAKEKGVYKGRPLLYSPNAKDPQKRV
                     IYHRVVEMLEEGKAISKIAKEVNITRQTVYRIKHDKGLS"
                     /name="recombinase family protein"
     gene            complement(16008..16907)
                     /locus_tag="NYR13_RS14745"
                     /old_locus_tag="NYR13_14745"
     CDS             complement(16008..16907)
                     /locus_tag="NYR13_RS14745"
                     /old_locus_tag="NYR13_14745"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000196697.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Mph(C) family macrolide 2'-phosphotransferase"
                     /protein_id="WP_000196697.1"
                     /translation="MTRHNEIIKCAEKYQLHIQPQTISLNESGLDFQVAFGKDKHGVEW
                     VLRLPRRPDVYKRTKPEKQTVDFLQKNVSFEIPKWKVHAKDLIAYPKLTGKPAATIDPE
                     IQNYVWEIEHKPLPENFINTLAETLVDLHNIPEENINVQHINIKTIQEIKNDFQRRMNK
                     VKETYGVSDELWNRWKQWLENDELWPRHATMIHGDLHPGHIMVDNQANVTGLIDWTEAT
                     HSDPSMDFIGHHRVFDDEGLEQLITAYGKAGGEIWPRMKEHIIELNAVFPMFIAEFAME
                     SGESAYETMALKELGMKE"
                     /name="Mph(C) family macrolide 2'-phosphotransferase"
     gene            complement(17006..18472)
                     /gene="msr(A)"
                     /locus_tag="NYR13_RS14750"
                     /old_locus_tag="NYR13_14750"
     ARG             complement(17010..18472)
                     /name="msr(A)"
                     /gene="msr(A)"
                     /gene_name="ABC-F type ribosomal protection protein Msr(A)"
                     /tool="amrfinderplus"
                     /drug_class="MACROLIDE/STREPTOGRAMIN"
                     /identity="100.0"
                     /coverage="100.0"
     gene            18946..19620
                     /locus_tag="NYR13_RS14755"
                     /old_locus_tag="NYR13_14755"
     CDS             18946..19620
                     /locus_tag="NYR13_RS14755"
                     /old_locus_tag="NYR13_14755"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6 family transposase"
                     /protein_id="WP_001105960.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TIYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDTEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVVTDQAPSTKAAMAKIIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6 family transposase"
     gene            <19678..20055
                     /locus_tag="NYR13_RS14760"
                     /old_locus_tag="NYR13_14760"
                     /pseudo=""
     CDS             <19678..20055
                     /locus_tag="NYR13_RS14760"
                     /old_locus_tag="NYR13_14760"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019834602.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]; GO:0006355 - regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="response regulator transcription factor"
                     /name="response regulator transcription factor"
     gene            20052..20933
                     /locus_tag="NYR13_RS14765"
                     /old_locus_tag="NYR13_14765"
                     /pseudo=""
     CDS             20052..20933
                     /locus_tag="NYR13_RS14765"
                     /old_locus_tag="NYR13_14765"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015581923.1"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA];
                     GO:0000155 - phosphorelay sensor kinase activity [Evidence
                     IEA]; GO:0004673 - protein histidine kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="sensor histidine kinase"
                     /name="sensor histidine kinase"
     gene            21049..21978
                     /locus_tag="NYR13_RS14770"
                     /old_locus_tag="NYR13_14770"
     CDS             21049..21978
                     /locus_tag="NYR13_RS14770"
                     /old_locus_tag="NYR13_14770"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000074567.1"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]; GO:0005524 - ATP binding [Evidence IEA];
                     GO:0016887 - ATP hydrolysis activity [Evidence IEA];
                     GO:0042626 - ATPase-coupled transmembrane transporter
                     activity [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_000793446.1"
                     /translation="MKNLNNIIEINNLTKQYGSQIAVNNLSITVESGQIYGFLGRNGAG
                     KTTTIRMLLGLIKPTKGNIKIFEKEFESNKTEILKNIGAMVETPGFYSNLTAKENLTIN
                     AKILGIQKENAIEEVLEIVGLASEKVKLFKNYSLGMKQRLGIARALLHNPELLILDEPT
                     NGLDPIGIKEIRKLIKDLAQSRNITILISSHILSEIEQLVDKVGIIHNGVLLEEIMYED
                     LKKKNRQFISISVSDEEKVACLLETNFGIYDYKIKENGEFKIYSHIDRQQEINRLLVLN
                     NIDVFQMRVIEDNLETYFEDLVGGGTIG"
                     /name="ABC transporter ATP-binding protein"
     gene            21971..22708
                     /locus_tag="NYR13_RS14775"
                     /old_locus_tag="NYR13_14775"
     CDS             21971..22708
                     /locus_tag="NYR13_RS14775"
                     /old_locus_tag="NYR13_14775"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000369394.1"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]; GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter permease"
                     /protein_id="WP_000369394.1"
                     /translation="MDNLLRTEFIKLKRSYMFLISILGTCVAPFMVVVASFISMRTKVP
                     TPNIVFKQLFEEVSLYHMLIIGPPLYGVIIAYLFGREYIEDTLKNLLIIPISRESFLVS
                     KIILLFLWIQTLSVIAWLLTLMLGMLLHFQGLSQSLIIDSFFTFVIGGVLLWILSPPII
                     ILSIYFKNYVPTIVLTIIITLINLMTANSEHRGLFPWAAVGDISRGTLPNTYPFLLSLI
                     IIIVTSIFSVIILFSYFKKTDIS"
                     /name="ABC transporter permease"
     gene            22722..>22898
                     /locus_tag="NYR13_RS14780"
                     /old_locus_tag="NYR13_14780"
                     /pseudo=""
     CDS             22722..>22898
                     /locus_tag="NYR13_RS14780"
                     /old_locus_tag="NYR13_14780"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_499250.1"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0050380 - undecaprenyl-diphosphatase
                     activity [Evidence IEA]"
                     /GO_process="GO:0016311 - dephosphorylation [Evidence IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="undecaprenyl-diphosphate phosphatase"
                     /name="undecaprenyl-diphosphate phosphatase"
     gene            22955..23629
                     /locus_tag="NYR13_RS14785"
                     /old_locus_tag="NYR13_14785"
     CDS             22955..23629
                     /locus_tag="NYR13_RS14785"
                     /old_locus_tag="NYR13_14785"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001105942.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS257 family transposase"
                     /protein_id="WP_001105956.1"
                     /translation="MNYFRYKQFNKDVITVAVGYYLRYALSYRDISEILRERGVNVHHS
                     TIYRWVQEYAPILYQIWKKKHKKAYYKWRIDETYIKIKGKWSYLYRAIDTEGHTLDIWL
                     RKQRDNHSAYAFIKRLIKQFGKPQKVITDQAPSTKVAMVKVIKAFKLKPDCHCTSKYLN
                     NLIEQDHRHIKVRKTRYQSINTAKNTLKGIECIYALYKKNRRSLQIYGFSPCHEISIML
                     AS"
                     /name="IS6-like element IS257 family transposase"
     gene            <23770..24405
                     /locus_tag="NYR13_RS14790"
                     /old_locus_tag="NYR13_14790"
                     /pseudo=""
     CDS             <23770..24405
                     /locus_tag="NYR13_RS14790"
                     /old_locus_tag="NYR13_14790"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009251744.1"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="aminoglycoside 6-adenylyltransferase"
                     /name="aminoglycoside 6-adenylyltransferase"
     gene            24402..24932
                     /gene="sat4"
                     /locus_tag="NYR13_RS14795"
                     /old_locus_tag="NYR13_14795"
     ARG             24403..24929
                     /name="sat4"
                     /gene="sat4"
                     /gene_name="streptothricin N-acetyltransferase Sat4"
                     /tool="amrfinderplus"
                     /drug_class="STREPTOTHRICIN"
                     /identity="97.78"
                     /coverage="100.0"
     gene            25025..25819
                     /gene="aph(3')-IIIa"
                     /locus_tag="NYR13_RS14800"
                     /old_locus_tag="NYR13_14800"
     ARG             25026..25816
                     /name="aph(3')-IIIa"
                     /gene="aph(3')-IIIa"
                     /gene_name="aminoglycoside O-phosphotransferase
                     APH(3')-IIIa"
                     /tool="amrfinderplus"
                     /drug_class="AMINOGLYCOSIDE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            26095..26666
                     /locus_tag="NYR13_RS14805"
                     /old_locus_tag="NYR13_14805"
                     /pseudo=""
     CDS             26095..26666
                     /locus_tag="NYR13_RS14805"
                     /old_locus_tag="NYR13_14805"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001079940.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="HTH domain-containing protein"
                     /name="HTH domain-containing protein"
     ARG             complement(16012..16907)
                     /name="mph(C)"
                     /gene="mph(C)"
                     /gene_name="Mph(C) family macrolide 2'-phosphotransferase"
                     /tool="amrfinderplus"
                     /drug_class="MACROLIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             complement(17007..18472)
                     /name="msrA"
                     /gene="msrA"
                     /gene_name="msr-type ABC-F protein"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic; streptogramin
                     antibiotic; streptogramin B antibiotic"
                     /identity="98.36"
                     /coverage="100.0"
     ARG             complement(16009..16907)
                     /name="mphC"
                     /gene="mphC"
                     /gene_name="macrolide phosphotransferase (MPH)"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic"
                     /identity="98.66"
                     /coverage="100.0"
     ARG             24415..24932
                     /name="SAT-4"
                     /gene="SAT-4"
                     /gene_name="streptothricin acetyltransferase (SAT)"
                     /tool="rgi"
                     /drug_class="nucleoside antibiotic"
                     /identity="97.16"
                     /coverage="95.56"
     ARG             4188..5032
                     /name="PC1 beta-lactamase (blaZ)"
                     /gene="PC1 beta-lactamase (blaZ)"
                     /gene_name="BlaZ beta-lactamase"
                     /tool="rgi"
                     /drug_class="penam"
                     /identity="96.8"
                     /coverage="100.0"
     ARG             23807..24108
                     /name="aad(6)"
                     /gene="aad(6)"
                     /gene_name="ANT(6)"
                     /tool="rgi"
                     /drug_class="aminoglycoside antibiotic"
                     /identity="99.0"
                     /coverage="36.23"
     Typing          complement(11249..11396)
                     /name="MOBQ"
                     /typing="oriT"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="5.980000000000001e-72"
     Typing          complement(11455..11630)
                     /name="rep_cluster_1017"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="92.697"
                     /coverage="94.0"
                     /evalue="1.04e-65"
     Typing          complement(11762..12744)
                     /name="rep_cluster_2100"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.593"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          13171..13913
                     /name="rep_cluster_1733"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 tttaattact ttaaccattg ctaccttcgt tgaaggtgcc tgatctgtaa ttaccttttg
       61 aggtttacca aattgtttaa tgagacgttt gataaacgca tatgctgaat gattatctcg
      121 ttgcttacgc aaccaaatat ctaatgtatg tccctctgca tcaatggcac gatataaata
      181 gctccatttt ccttttattt tgatgtacgt ctcatcaata cgccatttgt aataagcttt
      241 tttatgcttt ttcttccaaa tttgatataa aattggggca tattcttgaa cccaacggta
      301 gaccgttgaa tgatgaacgt ttacaccacg ttcccttaat atttcagata tatcacgata
      361 actcaatgca tatcttagat agtagccaac agctacagtg ataacatcct tgttaaattg
      421 tttatatctg aaatagttca tacagaagac tcctttttgt taaaattata ctataaattc
      481 aactttgcaa cagaacctca tttactatat gggcatctct ttcattatta atacaaagct
      541 ttgtatctcc gatattaggc aaaggtgtaa acgaattagg tgatactata ggattcaaca
      601 ttatattaat cgtttcttta ataatgatta tcttcttatt ttttataaat cgtagtaaaa
      661 atatctccta tgattatata aaagttcaaa gaggtgaagc caatgaataa attagaaaaa
      721 tggtctttgg tatttattat ttttacattt ctctcttcat tagcactttt atatttcaaa
      781 tataatttta gttcggttat gccagtccta agtctttcta ttttaactat actaatattg
      841 ttgacgagta ttattactgt agtttcagtt aatgatgaag atacttaaaa cgttcattag
      901 tgaaacaggt attatattaa aaaagcgtac gaatttgtac gcttttttct tgtgttatta
      961 ttaaaatctc ataacaggaa aatattatga gattttagac gctgtcagaa cgtctctttt
     1021 acatcgagtg acattgaatc aaagtctttg tatgttaatg atatataaaa ttatttagta
     1081 gattcattat agtaagctag attagttgct ctacttgttt ttattctctt ttgcctctaa
     1141 tttattgaga taacgataaa tagttgtacg tgaaacttgc cactgctctg caattgtttt
     1201 aattggcgta ccattatcat aaagtgtctt aagtaagttt aaatcttgtt tatttaattt
     1261 ttcaggtcta cctccatatc ggcctctagc acgtgctgca attcgaccgg ctgatgatcg
     1321 ctctaaaatt aaattacgtt caaactctgc aaatgctgcg aataaatgaa ataataattg
     1381 tcctgtagaa cttgatttat ccatcgttat attttcttct aaactatgaa aactcacacc
     1441 tcgttcgtta agttcattaa ctaacgtgat taaatcctcc atgttccgtc ctagtctatc
     1501 taatctccaa acaacaatcg tatctcctga cctcgcaaat tcaattgctt tatctaaacc
     1561 aggtcgctta ctttttgaac cactcatatg gtcattaaat atcttttcac aaccatatgt
     1621 atttaatcga tcctcctgta aattcaaatt ttgtaatcca gttgaaactc ttgcataacc
     1681 tattttcaaa atacagacct cctatataca cctttagtgt accataactt gattacgagg
     1741 tcttttgtga acatagattt tttgttgggt ttttgaacac ataattctat gtaatactta
     1801 cttatttaga caaaaaacaa gagtgtacag aaaatggtta ttttctggac actctcatct
     1861 ttaataatat attttaaatg tcattaacaa aactaattta ataagagtca agtatggttt
     1921 acatatgtat tatgtttgaa acatacctct aattactttt tactaatatc atttaaaatg
     1981 tctcgcaatt cttcaatttc tttgttattt aattcttcat ttttcgcaaa attcagcact
     2041 aaacttttca tatcccctcc atacagttta ttaagaaagg ttttagcagt tttcatttta
     2101 atatcgtctt ctttaatatt tgatgagtaa aaataaatat tttctgattt gtatcgtttt
     2161 ataatctctt ttttatatag tcttgtgatt aatgttctaa tcgttttatc actaacttct
     2221 ttatattttt gaatttcaac tacaatttca ttagctgata ctgatttttt atcccatatt
     2281 atattcataa catcccattc agccatagat atttcaactt gcttattggt catttaaaac
     2341 acccattcct tttaatattt tttcacttat taattcagca tttttcccag acgggtttcc
     2401 atctgataaa tgtgtagcaa aataatactt atcatgattt gtaattacgt aacctacaaa
     2461 ccacccatta ttatacttcc cgtttactat acctgtacct gttttcccat acagttcata
     2521 cttttcattt ttcttaatca ataatgaaga agataattga ttctttgctt ttttactaaa
     2581 atggttattt tgttccatca tatttttaaa aactattact tgttcaagat tagatatttt
     2641 caaactatct tccatccaat agcttttata acttcccaaa ttttcattac cataatttaa
     2701 ttgcttgagt tgagccgcag tatagttctt tggtatttga ttactaatac gttcgaagta
     2761 ccaattaact gaattttgca ttgctgtatt taaatcttgt tccttattcc aagactcgaa
     2821 aagataatgt ttatgattcc atgacatacg tgaattttta tcacttataa tatgacggtc
     2881 aagtccaaac agtgctaaat aaattttgta agttgaatca ggagaatatc tttttctact
     2941 ttctttttca ttataaatat agtatttgtc tttcttcatg ctgtacataa cgaaagatcc
     3001 actatttgaa ccaaaatttt tactttcatc taaaatttgg taatcgcttt gtaagggctt
     3061 tttataatta taatcagtta aggattgccc cattaaaaac tggctttgaa ttatcatgat
     3121 aaaaaaagta aaaatacaaa taaaaattag aattaatttt gactgctttt tcagatcggc
     3181 ttcttttata ttaattaatc tacttttgag taatgatttt ttaccattaa atgaatggct
     3241 taatatattt ttgttggaaa atggggtttt taatacggag tccataatag attccgcata
     3301 agttttaaat tcatttttgt taatattatt aaggacaaat ctatcggctt ctacttcatt
     3361 gtcatgaatt atctttcttt ttacaatatg tactaatgga ttgtaactca taataataga
     3421 gaagatatta aagataatta aatgtaaagt atctctattt ttagcatgag catattcatg
     3481 cagtattata tattttagtc ttttatcaat tacactttta aaatatgaac taggaatcaa
     3541 aataatatat ttcccatacc aaaaagttat tggagattga atagcctctg cttttcgaat
     3601 cacaatattt tttttatatt gatggttgaa aagtatcgta tctattttat ttttttcatt
     3661 ttcgtttaga taaagtgact gtttctttaa atatttaaga tataataagg ctttcaaaaa
     3721 tttaaaactt aaaataataa ctaaaactat ccaaataact gtgcagatat tatcaattga
     3781 atcccaatta aacttatgga tatctgttgt gaactcttga ataggtttgg tggtatttat
     3841 gttatggttc aaatcgtgtg acttactttc aactgtgggc gcttgattat tcacattatt
     3901 aaattttata aaagagaatt taattgggat aaaaggaatt aatccagcaa gcatagttag
     3961 ataccaaact ttataattta aactataatt aaaatagcgt tttaatatgt acctaaaaaa
     4021 tactaacaat agaaatataa aacaaaagct tactacgctc attattagta atttagccat
     4081 tttgacacct tctttcaaat atttataata aacaattgac atcaatatta caattgtaat
     4141 attattgatt tataaaaatt acaactgtaa tatcggaggg tttattttga aaaagttaat
     4201 atttttaatt gtaattgctt tagttttaag tgcatgtaat tcaaacagtt cacatgccaa
     4261 agagttaaat gatttagaaa aaaaatataa tgctcatatt ggtgtttatg ctttaaatac
     4321 taaaagtggt aaggaagtaa aatttaattc agataagaga tttgcctatg cttcgacttc
     4381 aaaagcgata aatagtgcta ttttgttaga acaagtacct tataataagt taaataaaaa
     4441 agtacatatt aacaaagatg atatagttgc ttattctcct attttagaaa aatatgtagg
     4501 aaaagatatc actttaaaag aacttattga ggcttcaatg acatatagtg ataatacagc
     4561 aaacaataaa attataaaag aaatcggtgg aatcaaaaaa gttaaacaac gtctaaaaga
     4621 actaggagat aaagtaacaa atccagttag atatgagata gaattaaatt actattcacc
     4681 aaagagcaaa aaagatactt caacgcctgc tgctttcggc aagactttaa ataaacttat
     4741 cgcaaatgga aaattaagca aaaaaaataa aaatttctta cttgatttaa tgtttaataa
     4801 taaaaacgga gacactttaa ttaaagatgg tgttccaaaa gactataagg ttgctgataa
     4861 aagtggtcaa gcaataacat atgcttctag aaatgatgtt gcttttgttt atcctaaggg
     4921 ccaatctgaa cctattgttt tagtcatttt tacgaataaa gacaataaaa gtgataagcc
     4981 aaatgataag ttgataagtg aaaccgccaa gagtgtaatg aaggaatttt aatattctaa
     5041 atgcataata aatactgata acatcttata gtttgtatta tattttgtat tatcgttgac
     5101 atgtataatt ttgatatcaa aaactgattt tccctttatt attttcgaga tttattttct
     5161 taattctctt taacaaacta gaaatattgt atatacaaaa aatcataaat aatagatgaa
     5221 tagtttaatt ataggtgttc atcaatcgaa aaagcaacgt atcttattta aagtgcgttg
     5281 cttttttctc atttataagg ttaaataatt ctcatatatc aagcaaagtg acaatagcat
     5341 tttacaagta ttttttattg ttcgattagg gtaaacctaa ataatacata aattatatta
     5401 caatatgttt attatagagg ctaaagtatc ttagaaattt ggatagtagg tttttcggga
     5461 ataaaagtat agttggcttt aatatataat taagctaagc tatcatttat atttactcga
     5521 ttataattcg cacttcaact tttttataac gtaaaaatta aaacgtagtt ttatttatct
     5581 ttagtaatat ctttttaaac actacagttt cttcattagt taaattagcg aagtaatgat
     5641 tattaagttg ataggctttc ttttctaatg ttggccataa gtcttttgct ttatttgtac
     5701 tgtttattag cacagttctt ctattttcat tatcagtttg acgtgttatt agatcctttt
     5761 tggacatctt atctaatatt ccagatattg ttgaaggttc taaatttaaa gtattaccaa
     5821 tcgctttagg tgtattcaaa ttactattaa tcaagcaatt caaaacacca tattctgctg
     5881 gagtaatatt atagggactt aataaacttt taaaatgttt aaaaactcta ttctgagaag
     5941 tactcaacaa ataatttata caattatcta attccacaac taaaacctct cttaaatcat
     6001 tagtattgac tcgcttatca tatcatgata agttttgtag gaaaatagtt ttgcaacaaa
     6061 aacatacttc tacaaaacaa ttgtgaaaga aggctaataa atgttcaatg cggtagtagt
     6121 gagaaaaagt gcatcaaatg ttagttataa agtagaaaaa gttgatgaat ctcatttatc
     6181 gaagggtgat gtattagtaa aagtggtata ctcttcaata aattataagg atatgctagc
     6241 tttacaatat aaaggcggtg taattagaga ttatcctatg attcctggta tagattttgc
     6301 aggtattgtt gaatcaagtt cgaatgataa gtttaaagaa ggcgataatg tattagttac
     6361 tggttatgat gttggcgtga cacatacagg tggattttca gaatatgcac aagtgcctgg
     6421 agagtggatt gttcctattc cccaagaaat gtctattaaa gagtctatgg tatatggcac
     6481 agccggtttt acggcagcat tatcaatttt tgaactagaa aaatatggaa tgaatatcaa
     6541 atcacaacct gaaattttag tgtctggggc tacaggtggt gtgggcagtg ttgctataca
     6601 aattttacat aaaattggat atgaaaatat cactgctatc gtaagaaaag aaaagcaaat
     6661 agaaatcgca aaaaaattag gtgcaaaaca agtaataata attgaagatg ataataaacc
     6721 gcttaaaaaa ggtatttttg attatttctt agatacagtg gggagtaatg taacattata
     6781 cggtttaaaa cgtctaaatt atcaaggtgt tgctactgta tgtggaaatg tagcaggaaa
     6841 ttcacttaac gctaatatat taccgtttat tcttagaggt attaaattaa ttggcattga
     6901 ttctgtatat gttgatcata atatccgtga agatatatgg agtaagttag caaatgaatg
     6961 gaatatagga aattcacttc tatacaatga aattggattt gaagaattct ataaaacgat
     7021 agatcagctt ttaaaaggac aacatttagg aagaactatt ttaaaagtat aagtgtgagt
     7081 attcattaat acatttacta ttaattcaat cattttgcat ttctctacta accagtgtta
     7141 taatttatat aacgaaaatg attaacaatt aatgcaccaa tccccacact attgcagtag
     7201 tgtggggatt ttttcgatgc tggcttataa agtcgcctat taattatttg ttgcgtttac
     7261 taagccaata agtataatac gcaacagcac agccactgat gactggtgct atgatgtgaa
     7321 cgaaaatgat tagcaaagta atgcacctcc tctcttcgtc aattgacgcc tgagagatag
     7381 gcgactctat tattatacca tctgtgaata tacaagcata tctacttccg ataagtcgtc
     7441 ttatgttata taactttgtt ttttatagta tcaagacaag aagaaactcg tttcaaaaac
     7501 cctcatgatt tttagagaaa aactctctta tttcatcgtc tttaataaaa taatatgcca
     7561 tctttccatc tttataaaaa tcaagtacct catttttata taaaagcctt aaatgatgtg
     7621 aagttgaagc aacactcatt ttcaatatca aagaaatatc acaaacacac aactcatctt
     7681 ctttaatcaa agataatatg attttcaatt tcttctcatc acaaattttt tctaaaatgt
     7741 taagtaattt cttagattta tcatcttcta aaaaacttaa agcattgtta actttatcct
     7801 catgtacaca gatcacatca caagtatttt cataactcat ataaaatcac accctaaatt
     7861 aaaatataaa tcctaaaatt gtttgaatag tgtcattttc aataataata aataaaccta
     7921 aagctatata aataatagcc ataatccaac gactaaattt ctcaacaatt tctccaattc
     7981 ctggaatatt agctaatttt tgtgcagtaa acaccaagaa gaaaattaaa attaaaaaga
     8041 caaacagagt aagtaataaa ttagtaacac ttaatgtcac aaaatacgga acaaataaac
     8101 caatattatc ggcgccacaa cttgctatcg taacaattgc aaccgtacca actaatttag
     8161 acaatccttt ttcattcaat tcttttttag ctctcttttc tccttcacaa tcatcataaa
     8221 tagccacttt aattccaaga taaattggta ttaaacccaa taaacctaat atccactttt
     8281 ctggaacata atttaataca aaagctaaaa acaaactaac taatattaaa ataatagacc
     8341 ctaaatattg accaacataa atatctctat attcttttct agtctttgct ctagcaaaaa
     8401 atattaataa aattactaat aaatcaactg ctgtagcaat ataaagaaca gcagcagcaa
     8461 caaccgtttg aatcataata cacctcattc aaaaatattt ttgaatgtat tataacttat
     8521 atttttaaat aatcataggt gctttattcc aattgcttta ttgacgttga gcctcggaac
     8581 ccttaacaat cccaaaactt gtcgaatggt cggcttaata gctcacgcta tgccgacatt
     8641 cgtctgcaag tttagttaag ggttcttctc aacatcaata aattttttcg gcataaatgc
     8701 gtgtctatgc gtagacatgg agacacttca gaattatgga gtgattacat gagtttaact
     8761 atttttcttt attcagtttt aggaagttta ttagcaaatt atatctacga aaaatcttca
     8821 aaataaataa ctttttcggt tctactttgt acactttatc tacctggtag acctaattgt
     8881 tattgcttta caggtctaaa attcgtcgtt ataatctagt taaatcccgt aagggcgcac
     8941 ttatacgtcg gataaatcga catgtgcaaa aacgtaatcg accttcgtcg atttttttat
     9001 ttcaaaatta aagaaacggc ttgagatatt ccgagcagtt ataaaaatta atttgcgttg
     9061 aatattgcta ctacattctt gaaaaagtga tgtagattta tagcccataa cttttttgaa
     9121 ttacatcgac gatacggcgt cgaaagaaaa ataaatagac cgtatgaaag aaaaagctac
     9181 ctcactttat ctggggtagc ttttattttt tatgccctta ttttgaattt taagagggca
     9241 ttttaaagat ttaggggtga ttcatatagt tttatatcta aaacttatat atgcttttaa
     9301 aacgcaaata tgagccaaat aaatatatgc tattttcaaa aacaaaaatt tgagcaaaaa
     9361 caataactat ttttagacac tgcccattta catgcaaatt aaaaattagc ataaaattct
     9421 ttaaaacttc cccacgtttt tctaaattcc tgtagggcgt ttttatcaaa aatcaagaca
     9481 agaagaaact cgttcacact cgtttcaaaa aaacaagaaa tctaatctat acacctaccg
     9541 ttttccaacc ccctcaaagc atacaaatta aaaacaaaat tattcataat cttactttct
     9601 tttaacaaaa acataaaaac cataaataga caaattaact atcaaaggca ataaacagta
     9661 taaaaaaacc acgaataaat cttcatcaac atctaaaata aaaaagaata aaacaattaa
     9721 caaaatacta attaacaaac ctaaaagtgg caaacttttt atatattttt ctaaattttc
     9781 attcataaaa tagactcctt tcaaaaatat gtttataaat atattaaaat aaatattgat
     9841 tttataaagc gcttacttat acaattaaaa tatcttatta tcttggaggt atcaaatgaa
     9901 aattataaaa ttattttcaa taatttcctt gttcctactg gtatttagcg cgaatttttc
     9961 taatgcttac gcaaatgaag aacaaaaaag ttctttacta gaaaatcaaa aagaaaaatt
    10021 gaaaagcaaa aacatcgaag tatcacaaat gaccaagaaa gaaataagtt ttctagaaca
    10081 attgcaaaat aaaaatgaag atatgcaaaa attcgaaaag caaatgaaaa aagaaggatt
    10141 taaaaaaata aagctagaag acaaaaattc taaattaaaa tatctagcta cagaagcaaa
    10201 tgataaaaat gcatatggct acatagctaa taacgcttat aaaaatgaaa aaacaaaaga
    10261 aattgtagtt tctgaaacaa tatatgataa ctacaacaaa aaaatcacaa aattcattgc
    10321 cgaaaaaaga agtatgactg aaaacaaaga gggaaaaata cttattaaca aaaattacgt
    10381 tgaatataag gctgaaaaag ttgataaaaa cagaccggta acatatgcag gattcaaatg
    10441 gaacggcaaa gcattcgctt gtagtatggc tggactttat gcatgtgctc actactgtgg
    10501 agtatgggca atcgtaaatc caatagccgg cggtgtatgt gaagcagttt gcggaactgc
    10561 atttgcagct ggatgctctg taggttgatt ttattccaat tgttttattg acgttgagcc
    10621 tcggaaccct taacaatccc aaaacttgtc gaatggtcgg cttaatagct cacgctatgc
    10681 cgacattcgt ctgcaagttt agttaagggt tcttctcaac atcaataaat tttttcggca
    10741 taaatacgat gttccttatt tatcctcata aaaaacaata gctgaaatat ataaccaatt
    10801 actgtgtgtt tgaatttcta atacatgaat atcattcttt aaaaacctat taacttgttt
    10861 atctaattga cgatgagtaa aagtagcgaa agttttaatc ttcatgatat ctctcctttt
    10921 ataaaaatag caatccttat tacaatatta aacactttta ttttggattt taagaggcat
    10981 tttgaagact tagaggcaaa tcatataggt tttgtactta aaaatctata cagtctctta
    11041 aaacgcaaat atgagccaaa taaatatatg ctaatttcac aaacaaaaat ttcagcaaaa
    11101 tcagtgacta attttttaga tactgcccat ttacatgcaa atttaaaaat tagcataaaa
    11161 tactttaaaa cttccccatg tttttctaaa ttcctgcagg gcttttctta tcaaaaactt
    11221 agaaatttta atttaactct aaaatctccg taagagcata agggaaattt gctatcattc
    11281 aaaaatgata gatctggcaa ggccagacat tccaagggtt ttaagttatt ttaaagtgat
    11341 atcatacaaa gctgtagtgt cacacttttg tgacactaca tacagcattt gtcacaaaaa
    11401 taagacagca cttttttaca gaaaaacaat aaaaaaagac atcagttatc actaatgtct
    11461 taaataataa ttttgctttt cgaaattcca aattgcggta attgaatgtg ctttttttct
    11521 tcgtctgtcg ttttatcttc atcacttgta ttaatcaaat taccatcttc ggcatcgtct
    11581 aagtttaaaa ttttatgctt ttgtttaagc aatccaccat aacttaacat acgttttcga
    11641 tacaaacctt tttctaaatc acttacaatt tcttgatttt tttcgtcgtc atcagttaaa
    11701 aagtcagatg atttaacgga atattttgat gtctcttcga gtgttataaa atcatttgaa
    11761 ttattgatta aagatattat attgtttcat gtttttacgg cgcatataaa gggcatgtgt
    11821 ttcttcaagt tcagttagaa ttgtttgcat taaataagct tgcattgact tgattgtttc
    11881 cttttggcct ttaactcccc tatcatgtat agctttttta agtcttttta aagaagttaa
    11941 tatttcatcc tcaatgtcct ctaacatgta atgcatatct tcatgccttg aattaaatga
    12001 tttttttgct ttaagaataa cagcctttat gatttctaaa tctctataat catattttaa
    12061 taaataatta gttagttgtt ctgggaattc ttgcaatagc atttctttat catcaaaatt
    12121 atgtgtaaat tgatttgaat gatttgaatg attactaatt tcatttttgt actttatatc
    12181 attcaagtca ttcatatcat tattctcagt atcattaaag tcaatgtcat taaagtcagt
    12241 atcattagtg ttcgattttc gaacttctgg acgttcgatt ttcgaacttc tggacgttcg
    12301 attttcgaac ttctggacgt tcgattttcg aacttccttc tcgccgtaag gttcaacatc
    12361 gttttcttct ttttctattt tgtaaatatc acgttctgtg acaataggtt tcattaaata
    12421 tagaatattt ggtttattta aaccacgtcg tttttgaatg agtagaccat cgttttctaa
    12481 cccttttttt atttttgtta acttttcttt tttacaattt aagatttcca ttagcttttc
    12541 atttgaataa acaaagtaaa tgttaccatc ttcatcaacc cagctatttt taatagataa
    12601 atttaagcga tcacgtaaga tagcataggc tattttcata tcattagtta gatttttata
    12661 attttcactg gtaaagaata ctttagggat ttgataaaat ctttctttgt aattttcttg
    12721 cactgtaaaa tattgatttt gcatgacaaa aaacctcttt ccatatttta gtttggtaag
    12781 aggtaataaa acgtttttat ttagctttac atttatttaa tgatttaggt gcttgcacta
    12841 agatattatt cattatataa tacaagtatc gaaaattata taaataaaca gtttctaaac
    12901 gttttattac caaaccccga ctattaccag tagttggggt ttttgttata ttaagtttat
    12961 tatagcactt taaataaact tataaaaggg aaaatatagc tttatcaagg gtttataaac
    13021 ccttgataaa tatcataaac ctttcataaa cccttgataa aaaggttgat ggatgtttat
    13081 ttttatttat taatcacttt attattaagc attataagct tataatattt tatcaagggt
    13141 ttataaacat tttataaagg gttgatgata tgaaaagtgt gaaaaagttg agtgaagaat
    13201 taggggttag taagcaaacg atttttaata atattaagcg attgaatata gagacaataa
    13261 aacaggaaaa cacttcgttt attaaagaag ataccgatat agaaaaaatc attcaaagag
    13321 taaatgaaaa taaaaagaaa tatggttttg aaagtactac tgaagacaaa caaaaaaaag
    13381 ggtcggataa tattaatttt gaatcgaaaa gcgatgctca aatagtagaa atccttaaaa
    13441 atcagattga tactttaaat aatcaaattg aaaaacaaga aagtcgtcat gaaacaacaa
    13501 ttgaatttta cagaaaagag ttgcaagaaa gatcaaaatt gcttgaaaat cagcaagttc
    13561 tggcattaga gagtaataaa aagattcaaa aattagaaaa tcaattagaa aaagaaaaac
    13621 accttaatta tccctttgat acatctacta acactagaca aaacgttgat gcacaagaaa
    13681 aaacatatac tactaatcct gtaaatatta acagagatca ggaagaaact aaagaaacag
    13741 agattcaata taaggatata tctggaagtc aaagcgacga aagtacacaa ggtgaagaag
    13801 caaaaaaaga agacgttcca gctaatctaa atgacaatga tagtgatata gaagaaaaga
    13861 gtgaagaaac ggaacctaaa aaggggtttt ggagtcgttt gtttggtagc taaaataatt
    13921 gattaggcac taaaagttat aaaattttag tgtcttttat atagtgagaa cttctggtaa
    13981 tcatcgatta tgtaaactaa agtatttcaa ataattaact gtattaatac tctcatcatg
    14041 attgcgttat aaacgttcgt tattgagaca aaatttaata gtactactac acaaaaagag
    14101 agtgcgaatt cgcactctct ttttgtgata aatgaatggt taagaaaata attcatccac
    14161 agttgtatca aacaatcttg ccaacttaaa tgctaatgtc aatgtaggat catatttatt
    14221 gttttctatt gcattaatag tttgcctaga cacttttaat tctttactta aagtttcttg
    14281 agaaattcct ttttgttttc tatattctct aattctattt ttcattaatt taacctttag
    14341 atgtatattt tttatttgta gtatagtaat taaacagcat aagaaatagt gctacaatta
    14401 taaagaaaat ttctggatat tgagaaaacc aagatccttc aatacttggt gacaaacctg
    14461 taaatttaag cactagtgta aataacatac aatatacaat ccaaataaaa cttttagcca
    14521 gtatttcaat aaacatttta cgttgtcttt catcgtatcg atcttgttgt ccttttttat
    14581 ctaatgtttc tgaaggtaaa tatttgttag ttatagccgt ccataaacaa gaaaaaatta
    14641 aaataataat aaaaggaatt aaattcatta taacacctca taaatgtaaa aagtatttga
    14701 catttatgag tgtaaatatt tttgatacaa atgtcaaata ctttttacat tataatatat
    14761 tttaaaacac cttattagta aaacaattac tatatagaaa gctgcgaact cgtactcttt
    14821 tttcttgtat aattattaaa atctcaattc aataatatgt tatggaattt gagacactgt
    14881 gagagacgct catttgcatt gacaatcaat ttatcaagat aatcccttat catgtttaat
    14941 tctataaact gtttgtcttg tgatattaac ttctttcgca atcttactaa tcgctttgcc
    15001 ttcttctaac atttccacca cgcgatgata aataacacgt ttctgtgggt ctttagcatt
    15061 tggtgaataa agtaaagggc gccctttata tacgcctttt tccttcgcaa cttgaatccc
    15121 ttgcgcttgt cgacgtttac tttcatttct ctcttgttct gaaaccattg ctaatatttg
    15181 aatgattaaa tctttcataa acttatccag taatggattg ccaattactt cattcatcat
    15241 aggtaagctg gtaatcatta actgaacgtc tttttctttt aaataattca cagtttcaat
    15301 aatttcatca tagttacgtc ctaaacgatc aatagattcc acaacgaatc gatctcccat
    15361 tctgacaaaa ttgagtgctt cttgaaatac aggtctattt tccactgact ttcccgactg
    15421 tttctctgta aagattttct ccacaccaaa cgtctttaaa ttatccaatt gtctttctaa
    15481 attttgatct atcgatgata ctctcgcata acctataatc attcatcttc actccataat
    15541 aaatatacac cctaatcata cgttttaatt gttataattt caacaattct ttttgtatgg
    15601 ttagggtgta ctcaaagtgt acatatctat aattaaaact tactaaaaat aaatatagat
    15661 tttttctttg taacagaacc gttcatttga aggtcatctc tatcataaat atttaaatta
    15721 actaaaaatt ttaatcatct gtttaatact tatgaaatgt atttacggta ggtattaaaa
    15781 ttgatgaaat ttatataagt gctttcaatg aaaatgaccg tttatttatc ctcctgattt
    15841 aaggagttag aaatttcgaa aacgattctt tccatttgtt gcatttgttc catgtccaga
    15901 tatttaatac attatagaaa accaaagacc atcactaatt aaacgcagtt ttaaaatttc
    15961 atcaggattg ccttcgtctt taaaatgggc ctcttttaat ataagttcta ctctttcata
    16021 cctaactctt tcaatgccat cgtttcatac gccgattctc ctgattccat agcaaactca
    16081 gcgataaaca ttgggaatac tgcattgagt tctattatat gctctttcat tcgtggccat
    16141 atttcacctc cagctttacc gtatgctgtt ataagttgct ctaatccttc gtcgtcgaat
    16201 acacgatggt gtcctataaa gtccattgat gggtcggagt gggttgcttc agtccagtct
    16261 atgagacctg tgacgtttgc ttggttatct accattatat gtcctggatg taagtcccca
    16321 tgtatcatgg tcgcatgtcg aggccatagt tcgtcgtttt ctaaccattg tttccatctg
    16381 ttccataatt catctgatac gccataagtt tctttaactt tattcattct tctttgaaag
    16441 tcatttttta tttcttgtat ggttttgata tttatatgct gaacgttaat gttttcttct
    16501 ggtatgttgt gtaaatctac gagtgtttca gctaatgtgt taataaagtt ttctggtaat
    16561 ggtttgtgtt caatttccca tacataattt tgtatttctg gatctattgt ggctgcgggt
    16621 ttacctgtaa gttttgggta agcaataagg tcttttgcat gtactttcca cttcggtatt
    16681 tcaaatgaaa cattcttctg taagaagtct accgtttgtt tttcgggttt tgttcgttta
    16741 taaacgtcag gtcttcttgg tagtctcaaa acccattcta ctccatgttt atcttttcca
    16801 aatgcaactt gaaaatcaag tcccgattca ttcaatgaga ttgtttgagg ttggatgtgt
    16861 aattgatatt tttctgcaca tttaataatt tcattatgtc gagtcatttt attggatcct
    16921 tatttctatt atatttttct tgtgaacgta ttttttatat tgatataaat gaacctaata
    16981 ttcaatataa attagtgtat agtttttaag ttatatcatg aagagattgt cctgttaatt
    17041 cccatttttt atctgataca tgtttaacaa accttgtatc atgtgatgta aacaaaatga
    17101 ttccaggata tttattcata aacatttcta atgcttctaa tgttttaata tctaaaaaat
    17161 tagttggttc atccaaaatt aacatattcg ctttcgttga aaataatact gctaacgata
    17221 atttcgttct ttccccacca ctcaaaacat tacaagaacg atcaagtgct tcatttaaac
    17281 ccaagttatt taaaatagct ctactgaatg attctgatga atccgtttca tccattaaat
    17341 attgcaataa tgaaacgtca cgcatgtctt cataagcaag ttgacgatag tatgccattt
    17401 gcactttagg agaacaatca attccctcta tttggtggta aatagcttca agtaaagttg
    17461 tcttacctac accatttgca cctacgagcg ctatattttt gccatatggt atttggaatc
    17521 gtacttgtgt tagcagtttt tgacttcctt taaccaatgt tagattttgt gcaatgattg
    17581 gataattatt atggatatca taaattttat tttgtgggaa attgaattca tgataacttt
    17641 gtggtttttc aacttcttcc aaatgttcca ttcttttttc aatatgctta gcttgttttt
    17701 gagcagcctt ctcaaccgtg cctttttgtt ttgatgcact taaacgatct ggtgctatac
    17761 ttttgttttt ttgttttgat gatgcttgtg ccatttgttg cgcttgattt cgtttagctt
    17821 tactggcttg ggacaatctt tgtttttcac ttatatactg ttcatattga cgttgttgtt
    17881 ctaactgttc ttgttcatat tgattttgat actgtgtgta attaccttta aacactctta
    17941 ttgtgccatc ttcttgtata tcccaaattg tgtcagcaat ttggtctata agtgctctat
    18001 catgacttac tataattaaa gtaccatagt aatattttaa aatatttttc agataatctt
    18061 taccaatttt atccaagtga tttgtaggtt catctaaaag taatatcgga ctataatttg
    18121 atatgacatt agctaattta tattttgctt tttcaccacc actcatactg tcggttgtat
    18181 gcataggtat atggagttca ctcattaaac taccgtctaa cgtgttaaaa tcattttcca
    18241 catccatgtt aagctgttca aaatattgaa tttcgccaac cgtttcaact gttccagatt
    18301 ctggttttgt tttttgagca atcatattta gtaatgtggt tttgccagta ccattacccc
    18361 caataagtgc tattttttca aattggtaag cgtaaagatg accgatgtta agtgatcgta
    18421 aatctgtcaa tttatgattg atttggttaa atttaattgt atattgttcc atatttatac
    18481 actccttgta tatttaaagg acgtgtacgc aaaaaaatga gacaggctac tcccgtctca
    18541 ttcacattac actttcaaac acttaaaaat ttattatgat gttttagtat ttgaaagcgt
    18601 ttattattcc tatcgaagga taaaaaatga cataagtcat cctatgagtg tgtattgcgg
    18661 acaagccttt ttgaattaat ttagttttgt attcaaaaag gtttatttga gtctcataga
    18721 agctgtcatt ttaatcctcc ttcatcgata aaatagtaat gttaatataa cattttgttg
    18781 gtttttttac aatatatctc taagtagaaa gattatataa caaaagtata aaaatacaat
    18841 tttagattga ttatacatct ccttaattta gagtgtactc ataaaatacg gttctgttgc
    18901 aaagttgaat ttataatata attttaacaa aaaggagtct tctgtatgaa ctatttcaga
    18961 tataaacaat ttaacaagga tgttatcact gtagccgttg gctactatct aagatatgca
    19021 ttgagctatc gtgatatatc tgaaatatta agagaacgtg gtgtaaacgt tcatcattca
    19081 acgatctacc gttgggttca agaatatgcc ccaattttat atcaaatttg gaagaaaaag
    19141 cataaaaaag cttattacaa atggcgtatt gatgagacgt atatcaaaat aaaaggaaaa
    19201 tggagctatt tatatcgtgc cattgataca gagggacata cattagatat ttggttgcgt
    19261 aagcaacgag ataatcattc agcatatgcg tttatcaaac gtctcattaa acaatttggt
    19321 aagcctcaaa aggtagttac agatcaggca ccttcaacga aggcagcaat ggctaaaata
    19381 attaaagctt ttaaacttaa acctgactgt cattgtacat cgaaatatct gaataacctc
    19441 attgagcaag atcaccgtca tattaaagta agaaagacaa gatatcaaag tatcaatacg
    19501 gcaaagaata ctttaaaagg tattgaatgt atttacgctc tatataaaaa gaaccgtagg
    19561 tctcttcaga tctacggatt ttccccatgc cacgaaatta gcatcatgct agcaagttaa
    19621 acgaacactg acatgatata ttagtgatta gctatatttt ttactttgca acagaaccag
    19681 ccatttaata tgactgttac aattactaag attcaagcac tattacgccg cacgtatgat
    19741 ttcaccactc aagttaataa tttaacagta gatgattgcg agttactact tgatgcagca
    19801 aagcttaaat ttaatgaaga aaccatagac ctgacacaca ctgaattgca aatcatgcat
    19861 agcttattcc agaacaaggg caaattcgtc agtcgtaatg cgttaatcga aaaatgctgg
    19921 gaatcagaac acttcattga tgacaatacg cttgctgtca acattacacg tttacgcaaa
    19981 aagctacaaa aactaggact tacagatttt atcgaaacga agaaaaatgt cggatatcgt
    20041 gtaggtgacg tatgaatttc ttgaaatcaa tccaacgtga aatttatatt gtcatcctta
    20101 cttgtgcttt attctacttt atattattca tgtataatgt gccgatgcaa gcatatatga
    20161 ttggtctagg tattgtattg tttgtttcaa tgatttactg gggtatccat tacatgaact
    20221 ttaaaaaaga ataaacacta caggaacaga acgaagattt aagaatcgaa aaccataaac
    20281 ttcgtaatga ctttattaac taccaaagtg agttagagtc atatttttta atgtgggtgc
    20341 atcaaatcaa gacaccgatt acagcatcaa agttactgct tgaagatcct gatgaacacg
    20401 tgatttctaa cgtgcgtaat gaagtcttac aaattgataa ttacacgaat cttgcactga
    20461 actatttgaa actcatgaac caaaagacat acatggtctt tatggaagtg agtgtagatg
    20521 aattaattcg accactgatt aaacgttatg cgatacagtt tattcatcat caaacaaagt
    20581 tgcattatga gaaaagtgaa gcggttatat taacagatgc caaatgggca tcaattatga
    20641 ttgagcaaat attaaacaat gcattaaaat atgcacgtgg caaagatgtg tggattacgt
    20701 ttgacgaaaa tacaaagaaa ttatcaatcc gagataacgg tatcggcatt aatgcgagtg
    20761 atttaccgaa aatctttgat aaaggtttct cgggctataa cggtagaata agtgagaaat
    20821 caagcggtat tggtttatat attgtcagca caatctcaaa gcgcttaggc cataaagtaa
    20881 gtgctacatc tacattaaac gatggttcaa tattcaccat tcaatttaaa taactccaat
    20941 ctttcatttt tgtaagatta gcggctgttt ttgtaagaat agataaaggc agccttttct
    21001 aatcgcgcgt aagataaagg taacaacaaa ctaagaaagg tgccagaggt gaaaaatttg
    21061 aataatataa ttgaaataaa taacttaaca aagcaatatg gaagtcagat agcagttaat
    21121 aatttgagta taactgttga aagtggacaa atttatggtt ttttaggaag aaatggtgca
    21181 ggcaaaacaa ctactataag aatgctttta ggcttaatta aacctacgaa aggtaatatt
    21241 aaaatatttg aaaaagagtt cgaaagtaat aaaactgaaa ttttaaaaaa tattggtgct
    21301 atggttgaaa cgccaggttt ttatagtaat ttgacagcta aagagaactt aactataaat
    21361 gctaaaatat taggtataca aaaagaaaat gcaattgaag aagtgttaga aatagtagga
    21421 ctagcttctg aaaaagtaaa attgtttaaa aattattctt taggtatgaa gcaacgttta
    21481 gggattgcga gagctttatt gcacaatccc gaattattga tacttgatga gccgacgaat
    21541 ggattagatc ctattggcat aaaagaaatt agaaagttga ttaaggatct ggctcaatct
    21601 agaaatataa ccattttaat ttcaagtcat atattgtcag aaatagagca gttagtagac
    21661 aaggtgggta ttattcataa cggagttttg ttagaagaaa ttatgtatga agatttaaaa
    21721 aaaaagaaca gacaatttat aagtatatca gtatcagatg aagaaaaagt tgcatgtttg
    21781 ttggaaacta acttcggaat ttatgactat aaaattaaag aaaatggcga atttaaaatt
    21841 tattcacata ttgatagaca acaagaaatt aatagattat tagtattaaa caatattgat
    21901 gttttccaga tgagagtgat agaagataat ctagaaactt atttcgaaga cttagtagga
    21961 ggtggcacaa ttggataatc tactccgtac agaatttatt aagttaaaaa gatcatatat
    22021 gtttctaata agtattttag gtacatgcgt agcacctttt atggtggttg tagcttcttt
    22081 tattagtatg cggacgaaag taccgactcc taatattgta tttaaacagt tatttgaaga
    22141 agtcagttta tatcatatgc taattattgg acctcctcta tatggggtta taatagccta
    22201 tttgtttgga agagaatata tagaagatac tttaaaaaac ttattaatta tacctatatc
    22261 tagagaaagt tttttagtaa gtaaaataat attattattc ttgtggattc aaacactatc
    22321 tgttattgca tggttgctaa ctttaatgct aggtatgcta ttgcattttc aagggttaag
    22381 ccagagttta ataattgatt cattctttac atttgttatt ggcggagtgt tattatggat
    22441 attatctcca ccaataatta ttttgtcgat atattttaaa aattatgttc ccacaattgt
    22501 tttaaccata ataattactt tgataaattt aatgactgct aattctgaac atagaggatt
    22561 atttccttgg gctgcagttg gagacatatc tagaggaaca ttacctaata cttatccatt
    22621 tctattatct ttaattatca taattgttac atctatattc agtgtaatta tattattctc
    22681 atactttaaa aaaactgata taagttaaaa ggaggagaaa aatgggtttt atagagcaga
    22741 ttaaagcatt tattttaggt gtagttgaag ggttgacaga atttgctcca gtatcatcaa
    22801 caggtcatat gattattgtt gatgatatgt ggttaaacac tgctgacgat ttaggaagtg
    22861 cgtctgcaac tacttttaag gtggtaatac agttaggagg ttctgttgca aagttgaatt
    22921 tataatataa ttttaacaaa aaggagtctt ctgtatgaac tatttcagat ataaacaatt
    22981 taacaaggat gttatcactg tagccgttgg ctactatcta agatatgcat tgagctatcg
    23041 tgatatatct gaaatattaa gagaacgtgg tgtaaacgtt catcattcaa cgatctaccg
    23101 ttgggttcaa gaatatgccc caattttata tcaaatttgg aagaaaaagc ataaaaaagc
    23161 ttattacaaa tggcgtattg atgagacgta tatcaaaata aaaggaaaat ggagctattt
    23221 atatcgtgcc attgatacag agggacatac attagatatt tggttgcgta agcaacgaga
    23281 taatcattca gcatatgcgt ttatcaaacg tctcattaaa caatttggta aacctcaaaa
    23341 ggtaattaca gatcaggcac cttcaacgaa ggtagcaatg gttaaagtaa ttaaagcttt
    23401 taaacttaaa cctgactgcc attgtacatc gaaatatctg aataacctca ttgagcaaga
    23461 tcaccgtcat attaaagtaa gaaagacaag gtatcaaagt atcaatacag caaagaatac
    23521 tttaaaaggt attgagtgta tttacgctct atataaaaag aaccgcaggt ctcttcagat
    23581 ctacggattt tcgccatgcc acgaaattag catcatgcta gcaagttaaa cgaacactga
    23641 catgatatat tagtgattag ctatattttt tactttgcaa cagaaccatc atttttatta
    23701 aaatactctt ttgtaaaatc tttctgctct tcaatgtatt taatttcttt acctctaaat
    23761 ctattatagc tatttgatga ttacaataaa attgatctta ccttattgcc cttggaagag
    23821 ttagataatt acctaaaggg cgataaatta ataaaggttc taattgataa agattgtaga
    23881 attaaaaggg acatagttcc gactgatata gattatcatg taagaaagcc aagcgcaagg
    23941 gagtatgatg attgctgcaa tgaattttgg aatgtaacac cttatgttat taaaggattg
    24001 tgccgtaagg aaattttatt tgctattgat cattttaatc agattgttcg ccatgagctg
    24061 ctgagaatga tatcatggaa ggtcggcatc gaaacaggct ttaaatgaag tgtaggcaag
    24121 aactataagt ttattgaaag gtatatatcc gaggatttgt gggagaaact tttgtccacc
    24181 taccggatgg attcctatga aaacatatgg gaagcattat ttctatgcca tcaattgttc
    24241 agggcggtat ccggtgaggt ggcggaaagg cttcattatg cctatccgga gtatgatagg
    24301 aatataacaa aatataccag ggacatgtat aaaaaataca ctggtaaaac cggctgcctg
    24361 gatagcacat atgccgctga tatagaagag aggcgggaac agtgattaca gaaatgaaag
    24421 cagggcacct gaaagatatc gataaaccca gcgaaccatt tgaggtgata ggtaagatta
    24481 taccgaggta tgaaaacgag aattggacct ttacagaatt actctatgaa gcgccatatt
    24541 taaaaagcta ccaagacgaa gaggatgaag aggatgagga ggcagattgc cttgaatata
    24601 ttgacaatac tgataagata atatatcttt actaccaaga cgataaatgc gtcggaaaag
    24661 ttaaactgcg aaaaaattgg aaccggtacg cttatataga agatatcgcc gtatgtaagg
    24721 atttcagggg gcaaggcata ggcagcgcgc ttatcaatat atctatagaa tgggcaaagc
    24781 ataaaaactt gcatggacta atgcttgaaa cccaggacaa taaccttata gcttgtaaat
    24841 tctatcataa ttgtggtttc aaaatcggct ccgtcgatac tatgttatac gccaactttg
    24901 aaaaagctgt tttctggtat ttaaggtttt agaatgcaag gaacagtgaa ttggagttcg
    24961 tcttgttata attagcttct tggggtatct ttaaatactg tagaaaagag gaaggaaata
    25021 ataaatggct aaaatgagaa tatcaccgga attgaaaaaa ctgatcgaaa aataccgctg
    25081 cgtaaaagat acggaaggaa tgtctcctgc taaggtatat aagctggtgg gagaaaatga
    25141 aaacctatat ttaaaaatga cggacagccg gtataaaggg accacctatg atgtggaacg
    25201 ggaaaaggac atgatgctat ggctggaagg aaagctgcct gttccaaagg tcctgcactt
    25261 tgaacggcat gatggctgga gcaatctgct catgagtgag gccgatggcg tcctttgctc
    25321 ggaagagtat gaagatgaac aaagccctga aaagattatc gagctgtatg cggagtgcat
    25381 caggctcttt cactccatcg acatatcgga ttgtccctat acgaatagct tagacagccg
    25441 cttagccgaa ttggattact tactgaataa cgatctggcc gatgtggatt gcgaaaactg
    25501 ggaagaagac actccattta aagatccgcg cgagctgtat gattttttaa agacggaaaa
    25561 gcccgaagag gaacttgtct tttcccacgg cgacctggga gacagcaaca tctttgtgaa
    25621 agatggcaaa gtaagtggct ttattgatct tgggagaagc ggcagggcgg acaagtggta
    25681 tgacattgcc ttctgcgtcc ggtcgatcag ggaggatatc ggggaagaac agtatgtcga
    25741 gctatttttt gacttactgg ggatcaagcc tgattgggag aaaataaaat attatatttt
    25801 actggatgaa ttgttttagt acctagattt agatgtctaa aaagctttaa ctacaagctt
    25861 tttagacatc taatcttttc tgaagtacat ccgcaactgt ccatactctg atgttttata
    25921 tcttttctaa aagttcgcta gatagagttc tatattagag atgtaaagag ttttggtgaa
    25981 gaggtttgtg agtatggctt ttataaccag ggtgcaatga gaagcactaa cagcagctag
    26041 cttaagaacg cataggatat actttttatg gaagtcacag aggaggaata aaatttgaac
    26101 aggattaaca gagtaacctc tattcttatt cagctgcaat caaaaaaata attcctgcca
    26161 aagaaattgc acagcgattt aatataagct taaggacagt ttacagagat atccggacac
    26221 ttgaagaagc cggaatacca attggatctg aggccggaaa aggatatttt cttgtagagg
    26281 gcttcctact tctgccggta atgtttacag cggcggaagt gggtgcattg attacagcag
    26341 ggaaattttt aaattgccat ggagatgaat catttataaa ggattttgat tcagctatgt
    26401 ataaaatcaa atctattttg aagcatggtg aaaaaaacta tgcacaggag ttggagaaca
    26461 gtattaacgt gtacagcaca tctggacaga aaaatacatt ggcggataac gttattgcag
    26521 caattcagac tgcaatctgc aataaaaggg taatatcaat tcaatatcct gcatcaggag
    26581 ggcaagaacc ggaaagcaga atgatagagc ctatatcact ggggttttat gaacagaact
    26641 ggtacttaat cggttttgca ggctaagaaa tgaatatagg aattttcgtg tggatcggat
    26701 taaaagcatt tgcatagaag aagagctctg tcaaagccat gatggctctt tggaacaaat
    26761 attaaaacaa atgctggttc tgttgcaaag taaaaaaata tagctaacca ctaatttatc
    26821 atgtcagtgt tcgcttaact tgctagcatg atgctaattt cgtggcatgg cgaaaatccg
    26881 tagatctgaa gagacctgcg gttcttttta tatagagcgt aaatacactc aatacctttt
    26941 aaagtattct ttgctgtatt gatactttga taccttgtct ttcttacttt aatatgacgg
    27001 tgatcttgct caatgaggtt attcagatat ttcgatgtac aatggcagtc aggtttaagt
    27061 ttaaaagc
//
