LOCUS       NZ_CP099525            10060 bp    DNA     circular CON 02-OCT-2023
DEFINITION  Klebsiella pneumoniae strain SZS128 plasmid pSZS128-ccl, complete
            sequence.
ACCESSION   NZ_CP099525
VERSION     NZ_CP099525.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN29161340
            Assembly: GCF_025258665.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 10060)
  AUTHORS   Jia,X., Jia,P., Zhu,Y., Liu,X., Yu,W. and Yang,Q.
  TITLE     Genome sequence of Klebsiella pneumoniae SZS128
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10060)
  AUTHORS   Jia,X., Jia,P., Zhu,Y., Liu,X., Yu,W. and Yang,Q.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-JUN-2022) Medical Research Center, Peking Union
            Medical College Hospital, No.1 Shuaifuyuan Wangfujing Dongcheng
            District, Beijing 100730, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. v0.4.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 200.0x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 10/02/2023 03:34:24
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,701
            CDSs (total)                      :: 5,580
            Genes (coding)                    :: 5,443
            CDSs (with protein)               :: 5,443
            Genes (RNA)                       :: 121
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 85
            ncRNAs                            :: 11
            Pseudo Genes (total)              :: 137
            CDSs (without protein)            :: 137
            Pseudo Genes (ambiguous residues) :: 0 of 137
            Pseudo Genes (frameshifted)       :: 49 of 137
            Pseudo Genes (incomplete)         :: 90 of 137
            Pseudo Genes (internal stop)      :: 16 of 137
            Pseudo Genes (multiple problems)  :: 17 of 137
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP099525.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..10060
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="SZS128"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:573"
                     /plasmid="pSZS128-ccl"
                     /geo_loc_name="China"
                     /lat_lon="39.54 N 116.25 E"
                     /collection_date="2018"
                     /collected_by="ZS"
     gene            complement(join(8389..10060,1..14))
                     /locus_tag="NG894_RS28395"
                     /old_locus_tag="NG894_28375"
     CDS             complement(join(8389..10060,1..14))
                     /locus_tag="NG894_RS28395"
                     /old_locus_tag="NG894_28375"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin-like bacteriocin tRNase domain-containing
                     protein"
                     /protein_id="WP_032440457.1"
                     /translation="MSGGDGRGPGNSGLGHNGGQASGNVNGTSGKGGPSSGGGTDPNSG
                     PGWGTTHTPNGDIHNYNPGEFGNGGSKPGGNGGNSGNHSGSSGGGQSSATAMAFGLPAL
                     ATPGAEGLALSVSGDALSAAVADVLAALKGPFKFGLWGIAIYGVLPSEIAKDDPKMMSK
                     IMTSLPADAVTETPASTLPLDQATVRVRQRVVDVVKDERQHIAVVAGRPMSVPVVDAKP
                     TKRPGVFSVSIPGLPSLQVSVPKGVPTAKAPPKGIVAEKGDSRPAGFTAGGNSREAVIR
                     FPKETGQKPVYVSVTDVLTPAQVKQRQEEEKRRQQAWDAAHPEEGLKRDYDKAKAELDA
                     EDKNIATLNSRIASTEKALPGARAAVQEADKKVKEAEANKDDFVTYNPPHEYGSGWQDQ
                     VRYLDKDIQNQNEKLKAAQASLNAMNESLSRDKAALTGAMESRKQKEKKAKDAENKLNE
                     EKNKPRKGTKDYGHDYHPVPKTEDIKGLGELKRGDPKTPKQGGGGKRARWYGDKKRKIY
                     EWDSQHGELEGYRASDGEHLGAFDPKTGKQVKGPDPKRNIKKYL"
                     /name="colicin-like bacteriocin tRNase domain-containing
                     protein"
     gene            341..586
                     /locus_tag="NG894_RS28400"
                     /old_locus_tag="NG894_28380"
     CDS             341..586
                     /locus_tag="NG894_RS28400"
                     /old_locus_tag="NG894_28380"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146442.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_032440458.1"
                     /translation="MTHLKLTPAEEKRLADAFVAQALAMGLKGNKTLPKAVKQQVRERV
                     LRAIQDEREARRAQEMRREKYEATETTFTWQPQRRR"
                     /name="hypothetical protein"
     gene            860..1231
                     /gene="tolA"
                     /locus_tag="NG894_RS28405"
                     /old_locus_tag="NG894_28385"
     CDS             860..1231
                     /gene="tolA"
                     /locus_tag="NG894_RS28405"
                     /old_locus_tag="NG894_28385"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001237044.1"
                     /GO_component="GO:0098567 - periplasmic side of plasma
                     membrane [Evidence IEA]"
                     /GO_function="GO:0005215 - transporter activity [Evidence
                     IEA]"
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell envelope integrity protein TolA"
                     /protein_id="WP_001237044.1"
                     /translation="MRLIPFILLALCSPLLLTACKHSTTQPPKIYTLDKSSKISSYAAA
                     IKTAVEMQMFEPEAYAGKMCTVRISIQRDGTLNSAIAEGGDPKLCKAAISAVTHAKIPP
                     APDENTWQIFKNAPLDFRP"
                     /name="tolA"
     gene            1228..1593
                     /locus_tag="NG894_RS28410"
                     /old_locus_tag="NG894_28390"
     CDS             1228..1593
                     /locus_tag="NG894_RS28410"
                     /old_locus_tag="NG894_28390"
                     /inference="COORDINATES: protein motif:HMM:TIGR01352.1"
                     /GO_function="GO:0015291 - secondary active transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TonB family protein"
                     /protein_id="WP_072354022.1"
                     /translation="MKAFTLTVLAAMFLTPVHAIPLKPVTTLQPTYPVQAAAKRIEGQV
                     TATFDILDDGRVDNVSLTGCHLFFRETLTAMRHWLYPAGHPAMRQVINFEFSLKNDGLQ
                     DPRPVTTQKLNDDGCRQ"
                     /name="TonB family protein"
     gene            1768..2046
                     /locus_tag="NG894_RS28415"
                     /old_locus_tag="NG894_28395"
     CDS             1768..2046
                     /locus_tag="NG894_RS28415"
                     /old_locus_tag="NG894_28395"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014542884.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CopG family ribbon-helix-helix protein"
                     /protein_id="WP_000093040.1"
                     /translation="MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEK
                     RSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWGTENEQDAPPCHR"
                     /name="CopG family ribbon-helix-helix protein"
     gene            2034..2348
                     /locus_tag="NG894_RS28420"
                     /old_locus_tag="NG894_28400"
     CDS             2034..2348
                     /locus_tag="NG894_RS28420"
                     /old_locus_tag="NG894_28400"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001136729.1"
                     /GO_function="GO:0008657 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) inhibitor activity
                     [Evidence IEA]; GO:0042803 - protein homodimerization
                     activity [Evidence IEA]"
                     /GO_process="GO:0030541 - plasmid partitioning [Evidence
                     IEA]; GO:0051290 - protein heterotetramerization [Evidence
                     IEA]; GO:0009432 - SOS response [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_071177730.1"
                     /translation="MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKT
                     LPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDREMDQIVIVTVRHQKESGYPGADSL
                     "
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            2512..2940
                     /locus_tag="NG894_RS28425"
                     /old_locus_tag="NG894_28405"
     CDS             2512..2940
                     /locus_tag="NG894_RS28425"
                     /old_locus_tag="NG894_28405"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001140599.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001140599.1"
                     /translation="MAKTLLNLSQAAQAAGITRRTLYNHVKQGKVTVSRDGKNNPVVDV
                     SELIRVYGNVNIPEKQIPGISHRENTQKNFPQEQLLAMQKELADLRQAVTLMLEDKTSR
                     EEERRQHDDERRKLQAEVDRLTTELTQKKKRFWSGWFS"
                     /name="hypothetical protein"
     gene            2966..3145
                     /locus_tag="NG894_RS28430"
                     /old_locus_tag="NG894_28410"
     CDS             2966..3145
                     /locus_tag="NG894_RS28430"
                     /old_locus_tag="NG894_28410"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rop family plasmid primer RNA-binding protein"
                     /protein_id="WP_000165970.1"
                     /translation="MTKQEKTALNMAKFIKDQSLLLLEKLNELDMDTPADMCERLHEDA
                     ETLWQVMRDKLGEE"
                     /name="Rop family plasmid primer RNA-binding protein"
     gene            complement(3172..3702)
                     /locus_tag="NG894_RS28435"
                     /old_locus_tag="NG894_28415"
     CDS             complement(3172..3702)
                     /locus_tag="NG894_RS28435"
                     /old_locus_tag="NG894_28415"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_071177729.1"
                     /translation="MALYMVFIEDVEDKDGERCIMPTSEHLEDMVVLAWQTGAYVFCFV
                     DRAQHLAMMKSIGMYDERLNSDEKATYFFTGENPQWERDKPTGMKLCDYLYRKVERFAI
                     ENGVQVVDAGKCSPEQINAMIEVVSERHGESAVNEKLKAELMREYNSRYFNVPVPELPE
                     DKPARRWWPFGKK"
                     /name="hypothetical protein"
     gene            complement(3709..4440)
                     /gene="mobC"
                     /locus_tag="NG894_RS28440"
                     /old_locus_tag="NG894_28420"
     CDS             complement(3709..4440)
                     /gene="mobC"
                     /locus_tag="NG894_RS28440"
                     /old_locus_tag="NG894_28420"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobC family replication-relaxation protein"
                     /protein_id="WP_071177728.1"
                     /translation="MTLEQYNVSHAKRQARNAEKTRLTLRWLREELCSTAELVARRLGI
                     AAVQPVYRFLDSLVAKGLLVRAKYPVDGRQVSVWGLTPHGVAFSFDEDEPLTDVIPFQP
                     SRVSAAQLPHRLAVQSLRLSMEGRGATGWRYLHRMALKGMKVPDALAELDGRTVAFEVE
                     RTVKSRRRYQEVVSGYLFNRRANGIDEIWYICPDRPTLVRVQRAILAVDEIVNPQTGEA
                     RKTVELDRERLFACFKFMTTE"
                     /name="mobC"
     gene            complement(4440..6404)
                     /locus_tag="NG894_RS28445"
                     /old_locus_tag="NG894_28425"
     CDS             complement(4440..6404)
                     /locus_tag="NG894_RS28445"
                     /old_locus_tag="NG894_28425"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004178196.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TraM recognition domain-containing protein"
                     /protein_id="WP_071177727.1"
                     /translation="MFNTDSLAWQWHIPELARQIYPWVSWLYREYYSLAGFFLVIGLFF
                     GLAELWAGRMRFVGLSHKARREYADRYKRDNNRTVPFSVLASLDSPGRMVRARRHVWNY
                     AYWLTGAAGLALLGGLVVAVFIESWGETVLRPDLYANADYYLLQPANLFGIAWCAGGLV
                     AGVLLARLLAFLLLDGHFAAADEAVNAKLNQESRRSSQRTGEMTDVRHLHFGEPVPVNA
                     LADFSTEQARKQQAVFLGKDEQGQPVLVPRDTWRKTNIQILGLPGSGKSAMATNALIRC
                     VRDFGDAVVYFDPKGDAWAPHVFRAHCPDFTLLDLRPGKPAQLNLFRDLDQYALKNLLV
                     AGFNLSETGDVADHYRISEQKAAKLIAEQFPQGANIQQVLAAAYALPEALKKDVKGLIT
                     KLENVADLSVLQTDSGIDVAGIINGGGCLYVIGSMDDEAVIRVQKMLFARCAQIIIARD
                     EFRRWPHASIMLDEIKYLLSKYVLNALGTLRSRDCNLLLAHQSLGDFGQCGQDLPADFV
                     KTTVLDNTPIRWFYRAASQESAQWAAGQTGEIRVDVERRRASREAGNVEHISGDSFIQK
                     EARPLFDVNTLQHLPDGFAVMTGLGVARLAFSSPLRVERREISLKTFPVLAKTDPLAEY
                     LPPADGGGPKADDDFAGLY"
                     /name="TraM recognition domain-containing protein"
     gene            complement(7888..8037)
                     /locus_tag="NG894_RS28450"
                     /old_locus_tag="NG894_28430"
     CDS             complement(7888..8037)
                     /locus_tag="NG894_RS28450"
                     /old_locus_tag="NG894_28430"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891188.1"
                     /GO_component="GO:0019867 - outer membrane [Evidence IEA]"
                     /GO_process="GO:0019835 - cytolysis [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin release lysis protein"
                     /protein_id="WP_032440454.1"
                     /translation="MKKVKTIFLFILIVAGFLLAACQANYIRDVQGGTVAPSSSSELTG
                     IAVQ"
                     /name="colicin release lysis protein"
     gene            complement(8122..8379)
                     /locus_tag="NG894_RS28455"
                     /old_locus_tag="NG894_28435"
     CDS             complement(8122..8379)
                     /locus_tag="NG894_RS28455"
                     /old_locus_tag="NG894_28435"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891189.1"
                     /GO_function="GO:0015643 - toxic substance binding
                     [Evidence IEA]"
                     /GO_process="GO:0030153 - bacteriocin immunity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin E3-like toxin immunity protein"
                     /protein_id="WP_032440455.1"
                     /translation="MGLKLRLTWFDKKTEEFKGEEYSKDFGDDGSVIESLGMPLKDNIN
                     NGEFDLKKEWVPLLQPFFKNQIKPDVDNCYIAFDYRDGNW"
                     /name="colicin E3-like toxin immunity protein"
     BGC             3389..10060
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          7207..7785
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="98.282"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(3713..4440)
                     /name="MOBC"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="93.416"
                     /coverage="100.0"
                     /evalue="1.34e-140"
ORIGIN
        1 tctccaccac tcataccgtt ttcctctttg acatttaaaa caataaatta aagccaacat
       61 actgtacata tacacagtat aattattacc ttactcctcc cgttttcagg tgtcaatata
      121 tgagattagt tctcatcttc aggcacaaaa aagcgcccgg agccacctgt aagcagatcg
      181 cgtcttttcc cgaaaatttc tcatggcaac aaattttatt atttaagaca ttcatcacac
      241 ttacatttca gatggtatag acacatctga aagctaactg gcatgaggag aggacctgcg
      301 gttaaactgt tcgggaaacc tgagacgccc ggaggccact atgacgcacc tgaaactgac
      361 tcccgctgaa gaaaagcgcc tggcggacgc ctttgtcgct caggcactgg ccatgggcct
      421 gaaagggaac aaaacgctgc caaaggcggt aaaacaacag gtgcgggaaa gggtgcttcg
      481 tgccattcag gacgaacgtg aagccaggcg ggcgcaggaa atgcgtcggg agaaatacga
      541 ggctacggaa accaccttca cctggcagcc acagcgccgc cggtaagggg tatttaccat
      601 aacgtcgcat tgcccgcacc gctcagacgg tctgagggcg tttccggcgg ctacgggata
      661 aaacaggcaa caaaccaccc ggaaaaccgc cggaaacgcg cccggtaaat tgtaacccgc
      721 tgcatgccta tgcacgcaac tgcatggcgg gccgtttggt gtaaaaacga tacgataagc
      781 cgtgtttatg taaatgaacg tggccgtaaa gagtgacaaa tatacatgta acatttttta
      841 ctgacaggtc atcaacccga tgcgtttaat accctttatc ctgctggcat tgtgcagccc
      901 cttactcctg acggcctgta agcattccac cacccagccg ccgaaaattt atactctgga
      961 taagtcatct aaaatcagta gctacgctgc ggccatcaag accgctgttg aaatgcagat
     1021 gtttgaacca gaggcctatg cgggaaaaat gtgcaccgtg cggatatcca tacaacgtga
     1081 tggcactctg aacagcgcca ttgctgaagg aggagatccg aaactctgta aagcagcaat
     1141 atcagccgtt acccacgcca aaattccgcc ggcaccggat gaaaatacct ggcaaatatt
     1201 caaaaacgcc cctctggatt tcagaccatg aaagctttta ctctgacagt gctggcggcc
     1261 atgttcctca ctccggtaca tgcgatacca ctaaaacccg taaccacact gcagccaacc
     1321 tacccggtac aggccgcagc aaaacgcatc gaaggtcagg tgaccgccac gtttgatatt
     1381 ctggacgatg gacgagtgga caacgtgtcg cttaccggct gtcacctttt ttttcgggaa
     1441 acgctgacgg caatgaggca ctggctatat cccgcagggc acccggcaat gcgacaggtt
     1501 ataaattttg aattcagtct gaaaaatgac ggcttacagg atccgcgacc agtcaccacc
     1561 caaaagctca atgatgatgg ttgccgccag taacaggtcc tttaacccgc aggctgcaat
     1621 agtcctggat gatgagtgag cctgtagcag ccctgattag tggaagcgaa gctgaaaaat
     1681 gggcagcaaa agccgtattt ctggcaaata gcgccgccac ggattaaagt agtcatgtgt
     1741 aatacatatg actacaaagg ggcttttatg tcatcagcaa catccatcag gctcgatgaa
     1801 gaacttaagg accggctgaa aacgctggcc gatgaccggc accgctcagc gcacgcgcta
     1861 atgctggagg caatcaccga atacatcgac cgggaagaga agcgcagcca gtacctgcgg
     1921 gacggacagg ccgcatggca gcactatcag gaaacgggtc tgcaccttac tgcggaagaa
     1981 gcggaagcct ggataagtac ctggggaact gagaacgagc aggatgctcc gccatgccac
     2041 aggtaacgat ttccgcgctg gcacagcgcg atttacaacg ccttcaggac tttctcaaaa
     2101 ccaaaaatcg gctggcagcc agaaaaggag gtgaggtgat cgtccgggct atccagcaac
     2161 tgaaaacatt gccagacatt ggccgcccgg tgccgtttct gccgctggaa tataaggaac
     2221 tggtgatcgg gtttggcgac agtggctatg tgatgctcta ccgccacgac cgggaaatgg
     2281 accagattgt gatcgtcacc gtcaggcatc agaaagaatc cgggtatccg ggggcagaca
     2341 gcctctaata accgatgacg ggggcgcaat tcattgcgtg gccgtcgccg gtttgacaag
     2401 cgcagcgcgt cagaaaacca catcctgaac ggaaaaacgg gtaaaattca gcgatacatt
     2461 taccgtgaga aattacacac ctttcacacc cgataaaatc aggggtatac agtggcgaaa
     2521 acattgctca acctttcaca ggcagcacaa gccgcgggca ttaccagaag aacgctatac
     2581 aatcatgtaa aacagggaaa ggttaccgtg tcacgtgacg ggaaaaacaa ccctgtcgtg
     2641 gatgtgtcag aactgatccg tgtatacgga aatgtgaata tccctgagaa acaaattccc
     2701 ggcatttcac accgtgaaaa tacacaaaaa aatttcccac aggaacagct tctggcaatg
     2761 caaaaggaac tggccgatct ccggcaggct gtcaccctga tgctggaaga taaaacatcc
     2821 cgggaagaag aacgccgcca gcacgatgat gagcgccgga aactccaggc cgaagtggac
     2881 agattgacaa cagaactgac acagaagaaa aaacgcttct ggtccggctg gtttagctga
     2941 gaacttaccg aagggaatgg agaacatgac gaagcaggaa aaaactgccc tcaatatggc
     3001 taaattcatt aaggatcagt cgctgctgtt gctggaaaag ctgaacgagc tggacatgga
     3061 taccccggcc gacatgtgcg aacggcttca cgaggatgcg gaaacactct ggcaggtgat
     3121 gcgggataag ctcggggaag aataacagca ccggccatgc cggtgctggc gttatttttt
     3181 gccgaacggc caccaccggc gggcgggttt gtcctccggc agttcaggca ccggcacgtt
     3241 aaaatagcgg ctgttatatt cccgcatcag ctccgctttc agcttctcgt tcaccgcgct
     3301 ttccccgtgc cgctcgctga ccacctcaat catcgcgtta atctgctccg gtgagcactt
     3361 cccggcatca accacctgca caccgttctc gatggcgaac cgctccacct ttcgatagag
     3421 gtaatcacac agcttcattc ctgtgggttt gtcccgttcc cattgcggat tttcaccggt
     3481 gaaaaagtac gtggcttttt cgtcgctgtt gagccgctcg tcatacatcc cgatggattt
     3541 catcatcgcc agatgctggg cccggtcgac aaaacagaaa acatacgccc cggtctgcca
     3601 ggcgagcacc accatgtctt ccagatgctc gctggttggc ataatgcagc gctcgccgtc
     3661 tttgtcttcc acgtcctcaa taaataccat gtacagcgcc ataatccctc actccgttgt
     3721 cataaattta aagcacgcga acagcctctc ccggtccagc tccaccgttt tgcgggcctc
     3781 gccggtctgt ggattcacga tttcatccac cgccagaatc gcccgctgta cccggacaag
     3841 cgtcggccgg tcagggcaga tgtaccagat ttcatcgatg ccgttcgccc ggcggttgaa
     3901 cagatacccg gacaccactt cctgataccg cctgcggctc ttgacggtgc gctctacctc
     3961 aaatgccacc gttctgccgt ccagctccgc cagcgcgtcc ggcactttca tccctttcag
     4021 ggccatacgg tgcaggtacc gccagccggt ggccccccgg ccctccatgg agaggcgcag
     4081 ggactgcacg gccagccggt gcggcagctg cgccgccgac acccttgacg gctgaaacgg
     4141 aataacgtcc gtcagcggct cgtcctcgtc gaacgagaac gccaccccgt gcggcgtcag
     4201 cccccacacg ctgacctgac ggccgtcaac cgggtatttc gcccggacca gcagcccttt
     4261 cgccaccaga ctgtccagga agcggtaaac cggctgtacc gccgcaatcc ccagccgtcg
     4321 cgcaaccagc tccgccgtgg aacacagctc ttcccgcagc cagcgcaggg tcagccgtgt
     4381 tttctccgcg ttccgcgcct gccgcttcgc gtggctgacg ttgtactgct ccagtgtcat
     4441 cagtaaagcc ccgcaaaatc atcatccgct tttggtccgc cgccgtcggc cggaggcagg
     4501 tactccgcca gcgggtccgt tttcgccagc accgggaagg ttttcagcga aatttcccgg
     4561 cgctcaaccc gcagcgggct gctgaacgcc agccgcgcca cgcccagccc ggtcatcacc
     4621 gcgaacccgt caggcaggtg ttgcagggtg ttcacgtcaa acagcggccg cgcctccttc
     4681 tggatgaagc tgtcgccgct gatgtgctcc acgttccccg cctcccggct ggcccggcgg
     4741 cgctccacgt ccacccggat ctccccggtc tggcccgccg cccactgcgc ggactcctgg
     4801 ctggccgcgc gatagaacca gcggatcggc gtgttatcca gtaccgtggt tttcacaaaa
     4861 tcagcgggca gatcctgccc gcactgaccg aagtcgccca gcgactggtg cgcgagcagc
     4921 aggttgcagt cccggctgcg cagcgtcccc agcgcgttca gcacgtactt cgacagcaga
     4981 tatttaatct catcgagcat gatgctcgcg tgcggccacc tccggaactc atcccgcgca
     5041 atgatgattt gcgcgcagcg ggcaaacagc atcttctgca cccggatcac cgcctcatcg
     5101 tccatcgagc cgatgacgta caggcagccg ccgccgttga ttatccccgc cacatcgata
     5161 ccgctgtccg tctgcaggac gctcaggtcg gccacgttct ccagcttggt gatcagcccc
     5221 ttcacgtcct ttttcagggc ctccggcaac gcgtacgccg ccgccagcac ctgctgaatg
     5281 tttgccccct gcgggaactg ctccgcaatc agcttcgccg ctttctgctc gctgatgcgg
     5341 tagtggtccg ccacgtcgcc ggtctcactc aggttaaacc cggcaaccag cagattcttc
     5401 agggcgtact ggtcgagatc gcggaacaga ttcagctgcg ccggtttccc cggccgcaga
     5461 tccagcaggg tgaagtccgg gcagtgcgcc cggaagacgt gcggcgccca cgcgtcccct
     5521 ttggggtcga agtacaccac agcgtccccg aaatcgcgta cgcagcgaat gagcgcgttg
     5581 gtggccatcg cgctcttgcc gctcccgggc aggccgagga tctgaatatt ggtcttgcgc
     5641 caggtatcac gagggaccag caccggctgg ccctgctcat ccttacccag aaacaccgcc
     5701 tgctgtttcc gggcctgctc cgtggaaaaa tcggccagcg cgttaaccgg taccggctcc
     5761 ccgaaatgca ggtggcggac gtctgtcatt tctccggtcc gctggctgct gcgccggctc
     5821 tcctgattca gtttcgcgtt caccgcctcg tcagcggccg caaaatgacc atcaagcagc
     5881 aggaacgcca gcagccgcgc cagaaggacg ccggcgacaa gccctccggc acaccaggct
     5941 atcccgaaca ggttagccgg ctgcagcagg taataatctg cgttcgcata gaggtccggg
     6001 cgcaggacgg tttctcccca gctctcgata aacacggcga caaccagccc ccccagaagg
     6061 gccagaccgg cagcgccggt cagccagtac gcgtagttcc agacatgtcg ccgtgccctg
     6121 accatccgcc cgggtgaatc cagcgaggcc agcaccgaaa atggcacagt ccggttatta
     6181 tcgcgcttat agcgatcggc atactcccgc cgcgccttat ggctcagccc cacaaaacgc
     6241 attcggccgg cccagagttc agccagaccg aaaaacaggc cgataaccag aaaaaaaccg
     6301 gccagactgt aatactcccg gtacagccag ctgacccacg ggtaaatctg ccgggccagc
     6361 tccgggatat gccactgcca ggcaagcgaa tccgtattaa acatgcaatc tctctccttc
     6421 agacgacggg tttaccggcg tgatgcgcag cccccgctgc acaagccgcg gacatgcccc
     6481 aaggcatggc ggcggcggtc acgtccgtgg tgattgcgtt cagctttcac cgcggaggcc
     6541 agcctctttc cgccccatgc ggaaaaggcg cagccccgga ggaacaacga gcacgcccca
     6601 gcgtgtgaga ggaaaaggcg gcaccccagt gcggtctttt ccggtgttcc ggcccccgtc
     6661 agagttcgcc atagcgagcg gctgaccacc cgcaaaatca ggagcagctt tgctgcttcg
     6721 tcaggtgcgt ccagcaccgt ggatttttgt gggtggtcag gcgtgagcct gacgggggcc
     6781 gggtgaattt ctggcgtggc cggcgtccag ccggacagag ccagaaagag gggaaaagac
     6841 cgtgcgtcgg tggcgtccag ccagcgtaag caaggtcttt tcccctgaag tcagccacgc
     6901 cccagcgggg atgacttgca tttctccgca aggagaaaaa agcaacagag ataggttaac
     6961 gtaaaatgtt cagcgaaaaa ccgacatggt tcacctatcc tgataattga tcgtcaggga
     7021 atagaaagac ttaatcaggg gacaatatcc cacatcagcg cgtccggtga ccgtcttgca
     7081 ggtgccgggg aaattgcgcc tcctcgctca ctcggtcgct acgctccggg cgtgagactg
     7141 cggcgggcgc tgcggacaca tacaaagtta cccacagatt ccgtggataa gcaggggact
     7201 aacatgtgag gcaaaacggc agggccgcgc cggtggcgtt tttccatagg ctccgccctc
     7261 ctgccagagt tcacataaac agacgctttt tcggtgcatc tgtgggagcc gtgaggctca
     7321 accatgaatc tgacagtacg ggcgaaaccc gacaggactt aaagatcccc accgtttccg
     7381 gtaggtcgct ccctcttgcg ctctcctgtt ccgaccctgc cgtttaccgg atacctgtcc
     7441 gccgttctcc cttgcgggaa gtgtggcgct ttctcatagc tcacacactg gtatctcggc
     7501 tcggtgtagg tcgttcgctc caagctgggc tgtaagcaag aactccccgt tcagcccgac
     7561 tgctgcgcct tatccggtaa ctgttcactt gagtccaacc cgggaaagca cgcaaaacgc
     7621 cactggcagc agccattggt aactgggagt tcgcagagga tttgtttagc taaacacgcg
     7681 gttgctcttg aagtgtgcgc caaagtccgg ctacactgga aggacagatt tggttgctgt
     7741 gctctgcgaa agccagttac cacggttaag cagttcccca actgacttaa ccttcgatca
     7801 aaccacctcc ccaggtggtt ttttcgttta cagggcaaaa gattacgcgc agaaaaaaag
     7861 gatctcaaga agatcctttg atcttttcta ctgaaccgcg atccccgtca gttcagagga
     7921 ggacgatggt gccaccgttc cgccctgaac atcccggata taatttgcct gacatgcggc
     7981 cagaagaaag ccagcaacaa tcaatataaa aagaaaaata gtctttacct ttttcatata
     8041 ctttccctgt atttaaagac tccggcattc atccctgaac accggaagtc agtatttcaa
     8101 atcatccttg ataatttttt gttaccagtt accgtcccga taatcaaaag ctatataaca
     8161 attatccaca tcaggtttta tttgattttt aaaaaatggc tgtagtaaag gaacccattc
     8221 tttcttcaaa tcaaactcac cattattaat attatccttt aaaggcattc ccaagctttc
     8281 aatgacagaa ccatcgtcac caaagtcttt agaatactct tcccctttaa actcttcagt
     8341 tttcttatca aaccatgtca aacgtaattt aagccccata tttacctctc aaagatattt
     8401 tttaatgttc cgttttggat ctggcccttt aacctgctta cccgttttgg gatcaaatgc
     8461 gcctaggtgt tcgccatcac tggcacgata cccttcaagc tcaccgtgct gggaatccca
     8521 ttcataaatt ttacgttttt tatcgccata ccatcgggcc cgcttaccac caccaccttg
     8581 tttaggtgtt ttaggatcac ctcgctttaa ctctccaagt ccctttatgt cttctgtttt
     8641 aggtactgga tgataatcat ggccgtagtc tttagtcccc ttgcgaggct tgttcttttc
     8701 ctcatttaac ttattttctg catccttcgc ttttttctcc ttttgtttcc ggctctccat
     8761 cgccccggta agtgcagcct tatctctgga taaggattca ttcattgcgt ttaaagatgc
     8821 ctgagccgct tttaatttct cattctgatt ctgaatatcc ttatcaagat agcgaacctg
     8881 atcctgccac ccggagccat attcatgagg cgggttataa gtcacaaaat catctttatt
     8941 tgcctctgcc tcttttacct ttttatcggc ttcctgaaca gcagcccttg caccggggag
     9001 cgccttctct gtcgatgcaa tgcggctgtt taaggtcgca atatttttat cttcggcatc
     9061 cagctcagct ttcgctttat catagtctct tttcagcccc tcttccggat gagcggcgtc
     9121 ccatgcctgc tggcgacgct tttcttcctc ctgacgctgt tttacctgtg ccggggtaag
     9181 aacatctgtc accgacacat aaaccggctt ctgtccggtc tctttcggga aacgaataac
     9241 ggcctcacgg gagttaccac cggctgtaaa accagccgga cgtgaatcac ctttttcagc
     9301 aacaatgcct tttggcgggg ctttcgctgt cggaacacct ttcggtacgc tcacctgcag
     9361 agacgggaga cccggaatcg acacactgaa tacccccgga cgttttgtcg gtttcgcatc
     9421 caccacaggg acactcattg gccgacctgc gacaaccgca atatgctgcc gctcatcctt
     9481 caccacatcc acaacccgtt gtctgacacg aaccgtcgcc tggtccagtg gtaaagtact
     9541 tgccggagtc tccgtcaccg catcggccgg taatgacgtc ataatttttg acatcatttt
     9601 cggatcatct tttgcaatct cagaaggcag cacaccgtag atcgcaatcc cccacagacc
     9661 aaacttaaac ggccccttca gggcagccag cacatcagca acggcggccg acaacgcatc
     9721 gccggaaact gataaagcca gtccttcagc ccccggagta gccagggcag gcagaccgaa
     9781 ggccatcgca gtggccgaag actgtccgcc accagagcta ccgctatgat tgccgctgtt
     9841 accaccatta ccaccgggtt tactcccgcc gttaccaaac tcccccggat tatagttatg
     9901 aatatctcca ttcggcgtat gcgtcgtacc ccagcccggc ccgctgtttg gatccgtacc
     9961 accacctgat gaagggccac ctttaccaga cgtaccgttc acattcccac tggcctgacc
    10021 accattatgt cccagacctg aattacccgg acctcgaccg
//
