LOCUS       NZ_CP096237             9996 bp    DNA     circular CON 21-FEB-2024
DEFINITION  Klebsiella pneumoniae subsp. pneumoniae strain DD02357 plasmid
            pDD02357-4, complete sequence.
ACCESSION   NZ_CP096237
VERSION     NZ_CP096237.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN27753786
            Assembly: GCF_027594905.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella pneumoniae subsp. pneumoniae
  ORGANISM  Klebsiella pneumoniae subsp. pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 9996)
  AUTHORS   Jiang,J., Xu,X. and Wang,M.
  TITLE     The complete genome sequences of 4 K1-ST23 CR-hvKp in China
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9996)
  AUTHORS   Jiang,J., Xu,X. and Wang,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-APR-2022) Institute of Antibiotics, Institute of
            Antibiotics, No. 12 Wulumuqi Road, Shanghai, Shanghai 200000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 01-AUG-2021
            Assembly Method                   :: Unicycler v. v0.4.9
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 200x
            Sequencing Technology :: Illumina+Oxford Nanopore GridION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/21/2024 04:48:58
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,653
            CDSs (total)                      :: 5,529
            Genes (coding)                    :: 5,366
            CDSs (with protein)               :: 5,366
            Genes (RNA)                       :: 124
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 88
            ncRNAs                            :: 11
            Pseudo Genes (total)              :: 163
            CDSs (without protein)            :: 163
            Pseudo Genes (ambiguous residues) :: 0 of 163
            Pseudo Genes (frameshifted)       :: 70 of 163
            Pseudo Genes (incomplete)         :: 89 of 163
            Pseudo Genes (internal stop)      :: 40 of 163
            Pseudo Genes (multiple problems)  :: 34 of 163
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP096237.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..9996
                     /organism="Klebsiella pneumoniae subsp. pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="DD02357"
                     /host="Homo sapiens"
                     /sub_species="pneumoniae"
                     /db_xref="taxon:72407"
                     /plasmid="pDD02357-4"
                     /geo_loc_name="China"
                     /lat_lon="39.87 N 116.28 E"
                     /collection_date="2017"
     gene            join(9338..9996,1..1303)
                     /locus_tag="M0537_RS28190"
                     /old_locus_tag="M0537_28155"
     CDS             join(9338..9996,1..1303)
                     /locus_tag="M0537_RS28190"
                     /old_locus_tag="M0537_28155"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="TraM recognition domain-containing protein"
                     /protein_id="WP_099752043.1"
                     /translation="MFNTDSLAWQWHIPELARQIYPWVSWLYREYYGLAGAFLVIGLFF
                     GLAELWAGRMRFVGLSHKERREYADRYKRDNNRTAPFSVLASLDSPGRMVRVRRHVWNY
                     AYWLTGAAGLALLGGLVVAVFIESWGETVLRPDLYANADYYLLQPANLFGITWCAGGLV
                     VGIVLARLLAFLLLDGHFAAADEAVNAKLNQESRRSSQRTGEMTDVRHLHFGEPVPVNA
                     LADFSTEQARKQQAVFLGKDEQGQPVLVPRDTWRKTNIQILGLPGSGKSVMATNALIRC
                     VRDFGDAVVYFDPKGDAWAPHVFRAHCPDFTLLDLRPGKPAQLNLFRDLDQYALKNLLV
                     AGFNLSETGDVADHYRISEQKAAKLIAEQFPQGANIQQVLAAAYALPEALKKDVKGLIT
                     KLENVADLSVLQTDSGIDVAGIINGGGCLYVIGSMDDEAVIRVQKMLFARCAQIIIARD
                     EFRRWPHASIMLDEIKYLLSKYVLNALGTLRSRDCNLLLAHQSLGDFGQCGQDLPADFV
                     KTTVLDNTPIRWFYRAASQESAQWAAGQTGEIRVDVERRRASREAGNVEHISGDSFIQK
                     EARPLFDVNTLQHLPDGFAVMTGLGVARLAFSSPLRVDRREIPLKTFPVLAKTDPLAEY
                     QSEAGRQRPGDDDFAGLY"
                     /name="TraM recognition domain-containing protein"
     gene            1303..2034
                     /gene="mobC"
                     /locus_tag="M0537_RS28195"
                     /old_locus_tag="M0537_28160"
     CDS             1303..2034
                     /gene="mobC"
                     /locus_tag="M0537_RS28195"
                     /old_locus_tag="M0537_28160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobC family replication-relaxation protein"
                     /protein_id="WP_020956927.1"
                     /translation="MALERYNVSHAKRQARNAEKTRLTLRWLREELCSTAELVARRLGI
                     AAVQPVYRFLDSLVAKGLLVRAKYPVDGRQISVWGLTPHGVAFSFDEDEPLTDIIPFQP
                     SRVSAAQLPHRLAVQSLRLAMEARGATGWRYLHRIALKGMKVPDALAELDGRTVAFEVE
                     RTVKSRRRYQEVVSGYLFNRRANGIDEIWYICPDRATQVRVQRAILSVDEIVNPQTGEA
                     RKTAELDRERLFACFKFMTTE"
                     /name="mobC"
     gene            2041..2571
                     /locus_tag="M0537_RS28200"
                     /old_locus_tag="M0537_28165"
     CDS             2041..2571
                     /locus_tag="M0537_RS28200"
                     /old_locus_tag="M0537_28165"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_004146446.1"
                     /translation="MALYMVFIEDAEDRDGERCIMPTSEHLEDMVVLAWQTGAYVFCFV
                     DRTQHLAMMKSIGMYDERLNSDEKATYFFTGENPQWERDKPAGMKLCDYLYRKVERFAI
                     ENGVQVVDAGKCSPEQISAMIEVVSERHGESAVNEKLKAELMREYNSRYFNVPVPELPE
                     DKSARRWWPFGKK"
                     /name="hypothetical protein"
     gene            complement(2599..2778)
                     /locus_tag="M0537_RS28205"
                     /old_locus_tag="M0537_28170"
     CDS             complement(2599..2778)
                     /locus_tag="M0537_RS28205"
                     /old_locus_tag="M0537_28170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rop family plasmid primer RNA-binding protein"
                     /protein_id="WP_000165970.1"
                     /translation="MTKQEKTALNMAKFIKDQSLLLLEKLNELDMDTPADMCERLHEDA
                     ETLWQVMRDKLGEE"
                     /name="Rop family plasmid primer RNA-binding protein"
     gene            2847..3224
                     /locus_tag="M0537_RS28210"
                     /old_locus_tag="M0537_28175"
     CDS             2847..3224
                     /locus_tag="M0537_RS28210"
                     /old_locus_tag="M0537_28175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_004146445.1"
                     /translation="MAWVTVRQATELTGKARSSLYRDMAKGRVSYRTEADGGRVVDTSE
                     LIRVYGELRQGETHERDGLRLPDETEKTASDALIAEIKALREEVAGLRQEMQAMRLLEH
                     KPETAETPAGTPRRWWQWGKR"
                     /name="hypothetical protein"
     gene            complement(3286..3585)
                     /locus_tag="M0537_RS28215"
                     /old_locus_tag="M0537_28180"
     CDS             complement(3286..3585)
                     /locus_tag="M0537_RS28215"
                     /old_locus_tag="M0537_28180"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009365129.1"
                     /GO_function="GO:0008657 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) inhibitor activity
                     [Evidence IEA]; GO:0042803 - protein homodimerization
                     activity [Evidence IEA]"
                     /GO_process="GO:0030541 - plasmid partitioning [Evidence
                     IEA]; GO:0051290 - protein heterotetramerization [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_023389908.1"
                     /translation="MPYDVEWKQGAIEDVTMLFDYIAENSSLWDAQNVTDRVLTAADKL
                     ADFPRLYEVDSRYGEDVRRISLMGQHVLYDVDDQTRKVRVLAVVGQRQNPHTVR"
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            complement(3575..3838)
                     /locus_tag="M0537_RS28220"
                     /old_locus_tag="M0537_28185"
     CDS             complement(3575..3838)
                     /locus_tag="M0537_RS28220"
                     /old_locus_tag="M0537_28185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000072676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_004146443.1"
                     /translation="MSNTTHYENANFLRELAENLPRILPESDPDKAALLQRLANEELAQ
                     AEYEDQVRAKVTAARADTRPGMTTEQLRQRLHGRYQELRDAV"
                     /name="hypothetical protein"
     gene            4612..5130
                     /locus_tag="M0537_RS28225"
                     /old_locus_tag="M0537_28190"
     CDS             4612..5130
                     /locus_tag="M0537_RS28225"
                     /old_locus_tag="M0537_28190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321407.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_020956924.1"
                     /translation="MQKVTDLYPPEIARHKLQNHFAGNTVMLELIQKLNKTSLCTFAAL
                     CDGNVVTTSGYNITADLCVNRASAVAHSLKQKYLPVTARTISTKADVGGAVKQAAFCID
                     EDDLARLKSEPEKMMKECERNLNSQKRTNAQKEMSRLYKEFGEDGILALLRNVAQSNGT
                     PPPGAHPAS"
                     /name="hypothetical protein"
     gene            5715..7403
                     /locus_tag="M0537_RS28230"
                     /old_locus_tag="M0537_28195"
     CDS             5715..7403
                     /locus_tag="M0537_RS28230"
                     /old_locus_tag="M0537_28195"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000012966.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin-like bacteriocin tRNase domain-containing
                     protein"
                     /protein_id="WP_099722058.1"
                     /translation="MSGGDGRGPGNSGLGHNGGQASGNVNGTSGKGGPSSGGGTDPNSG
                     PGWGTTHTPNGDIHNYNPGEFGNGGSKPGGNGGNSGNHSGSSGGGQSSATAMAFGLPAL
                     ATPGAEGLALSVSGDALSAAVADVLAALKGPFKFGLWGIAIYGVLPSEIAKDDPKMMSK
                     IMTSLPADAVTETPASTLPLDQATVRVRQRVVDVVKDERQHIAVVAGRPMSVPVVDAKP
                     TKRPGVFSVSIPGLPSLQVNVPKGVPTAKAPPKGIVAEKGDSRPAGFTAGGNSREAVIR
                     FPKETGQKPVYVSVTDVLTPAQVKQRQEEEKRRQQAWDAAHPEEGLKRDYDKAKAELDA
                     EDKNIATLNSRIASTEKALPGARAAVQEADKKVKEAEANKDDFVTYNPPHEYGSGWQDQ
                     VRYLDKDIQNQNEKLKAAQASLNAMNESLSRDKAALTGAMESRKQKEKKAKDAENKLNE
                     EKNKPRKGVKDYGHDYHPAPKTEEIKGLGELKKAPKKTPKQGGGGRRDRWIGDKGRKIY
                     EWDSQHGELEGYRASDGEHLGAFDPKTGKQIKGPDPKGRNIKKYL"
                     /name="colicin-like bacteriocin tRNase domain-containing
                     protein"
     gene            7413..7670
                     /locus_tag="M0537_RS28235"
                     /old_locus_tag="M0537_28200"
     CDS             7413..7670
                     /locus_tag="M0537_RS28235"
                     /old_locus_tag="M0537_28200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin immunity family protein"
                     /protein_id="WP_047067361.1"
                     /translation="MGLKLNLTWFDKKTEEFIGEEYSKDFGDDGSVIESLGMPLKDNIN
                     NGGFDVEKSWVPLLQPYFKNKIEVDKYWYQISFDYRDGNW"
                     /name="cloacin immunity family protein"
     gene            7755..7904
                     /locus_tag="M0537_RS28240"
                     /old_locus_tag="M0537_28205"
     CDS             7755..7904
                     /locus_tag="M0537_RS28240"
                     /old_locus_tag="M0537_28205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891188.1"
                     /GO_component="GO:0019867 - outer membrane [Evidence IEA]"
                     /GO_process="GO:0019835 - cytolysis [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin release lysis protein"
                     /protein_id="WP_020956931.1"
                     /translation="MKKVKVVFLFILIFLGFLLVACQANYIRDVQGGTVAPSSSSELTG
                     IAVQ"
                     /name="colicin release lysis protein"
     BGC             715..9996
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          complement(8008..8586)
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="98.625"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          1304..2031
                     /name="MOBC"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="95.062"
                     /coverage="100.0"
                     /evalue="9.930000000000001e-144"
ORIGIN
        1 taacgcgctg gccgattttt ccacggagca ggcccggaaa cagcaggcgg tgtttctggg
       61 taaggatgag cagggccagc cggtgctggt cccgcgtgat acctggcgca agaccaacat
      121 tcagatcctc ggcctgcccg ggagcggcaa gagcgtgatg gccaccaacg cgctcattcg
      181 ctgcgtacgc gatttcgggg acgcggtggt gtacttcgac ccgaaagggg acgcgtgggc
      241 accgcacgtc ttccgggcgc actgcccgga cttcaccctg ctggatctgc ggccggggaa
      301 accggcgcag ctgaatctgt tccgcgatct cgaccagtac gccctgaaga atctgctggt
      361 tgccgggttt aacctgagtg agaccggcga cgtggcggac cactaccgca tcagcgagca
      421 gaaagcggcg aagctgattg cggagcagtt cccgcagggg gcaaacattc agcaggtgct
      481 ggcggcggca tacgcgctgc cggaggccct gaaaaaggac gtgaaggggc tgatcaccaa
      541 gctggagaac gtggccgacc tgagcgtcct gcagacggac agcggcatcg acgtggcggg
      601 gataatcaac ggcggcggct gcctgtacgt catcggctcg atggacgatg aggcggtgat
      661 ccgggtgcag aagatgttgt ttgcccgctg cgcgcaaatc atcattgcgc gggatgagtt
      721 ccggaggtgg ccgcacgcga gcatcatgct cgatgagatt aaatatctgc tgtcgaaata
      781 cgtgctgaac gcgctgggga cgctgcgcag ccgggactgc aacctgctgc tcgcgcacca
      841 gtcgctgggc gacttcggcc agtgcggcca ggatctgccc gctgattttg tgaaaaccac
      901 ggtactggat aacacgccga tccgctggtt ctatcgcgcg gccagccagg agtccgcgca
      961 gtgggcggcg ggccagaccg gggagatccg ggtggacgtg gagcgccgcc gggccagccg
     1021 ggaggcgggg aacgtggagc acatcagcgg cgacagcttc atccagaagg aggcgcggcc
     1081 gctgtttgac gtgaataccc tgcaacatct gcctgacggg ttcgcggtga tgaccgggct
     1141 gggcgtggcg cggctggcgt tcagcagccc gctgcgggtt gatcgccggg aaattccgct
     1201 gaaaaccttc ccggtgctag cgaaaacgga cccgctggcg gagtaccagt cggaggccgg
     1261 gcggcagcgg ccgggtgatg atgattttgc ggggctgtac tgatggcact ggagcgatac
     1321 aacgtcagcc acgcgaaacg gcaggcgcgg aacgcggaga aaacacggct gaccctgcgc
     1381 tggctgcggg aagagctgtg ttccacggcg gagctggttg cgcgacggct ggggattgcg
     1441 gcggtacagc cggtttaccg cttcctggac agcctggtgg cgaaagggct gctggtccgg
     1501 gcgaaatacc cggttgacgg ccgtcagatc agcgtgtggg ggctgacgcc gcacggggtg
     1561 gcgttctcgt tcgacgagga cgagccgctg acggacatta ttccgtttca gccgtcgcgg
     1621 gtgtcggcgg cgcagctgcc gcaccggctg gccgtgcagt ccctgcgcct cgccatggag
     1681 gcccgggggg ccaccggctg gcggtacctg caccgtattg ccctgaaagg gatgaaggtg
     1741 ccggacgcgc tggcggagct ggacggcaga acggtggcgt ttgaggtgga gcgcaccgtg
     1801 aagagccgca ggcgctatca ggaggtggtg tccgggtatc tgtttaaccg ccgggcgaac
     1861 ggcatcgatg aaatctggta catctgcccg gaccgggcga cgcaggtcag ggtgcagcgg
     1921 gcgatcctgt cggtggatga aatcgtgaat ccacagaccg gcgaggcccg caaaacggcg
     1981 gagctggatc gtgaacggct gtttgcgtgc tttaaattta tgacaacgga gtgagggatt
     2041 atggcgctgt acatggtatt tattgaagat gcggaggacc gggacggcga gcgctgcatc
     2101 atgccgacca gcgagcatct tgaagatatg gtggtgctcg cctggcagac cggggcgtat
     2161 gttttctgtt ttgtcgaccg gacccagcat ctggcgatga tgaaatccat cgggatgtat
     2221 gacgagcggc tcaacagcga cgaaaaagcc acgtactttt tcaccggtga aaatccgcaa
     2281 tgggaacggg acaaacccgc aggaatgaag ctgtgtgatt acctctatcg caaggtggag
     2341 cggttcgcca tcgagaacgg tgtgcaggtg gttgatgccg ggaagtgctc accggagcag
     2401 attagcgcga tgattgaggt ggtcagcgag cggcacgggg aaagcgcggt gaacgagaag
     2461 ctgaaagcgg agctgatgcg ggaatataac agccgctatt ttaacgtgcc ggtgcctgaa
     2521 ctgccggagg acaaatccgc ccgccggtgg tggccgttcg gcaaaaaata aacgccagca
     2581 ccggccatgc cggtgctgtt attcctcccc gagcttatcc cgcatcacct gccagagtgt
     2641 ttccgcatcc tcgtgcagcc gctcgcacat gtcggccggg gtatccatat ccagctcgtt
     2701 cagtttctcg agcaacagca gcgactggtc cttaatgaat ttagccatat tgagggcagt
     2761 tttttcctgt tttgtcatga ttctttcctt ccgggcatgg tgtgcgcctg tcgggtatac
     2821 tgtctcaaaa atagcggagt gagacaatgg cgtgggtgac tgtgagacag gcgacggaac
     2881 tgacggggaa agcccggagt tccctgtatc gggatatggc gaaaggccgc gtatcatacc
     2941 gtacggaagc tgatggtggt cgggtggtgg ataccagcga gcttatccgg gtgtacggtg
     3001 agttaagaca gggtgagact cacgagcggg acgggttgag actgccggat gagactgaaa
     3061 aaacggcctc cgacgcgttg atcgcggaga taaaagcact cagggaggag gtggccggac
     3121 tgcggcagga aatgcaggcc atgagactgc tggaacacaa accggagaca gcagagacac
     3181 cggccggaac accgcgccgg tggtggcagt ggggaaaacg ctgacgcgct gtgcttgtcc
     3241 aaccggcgac ggccacgcaa tgaattgcgc ccccgtcacc ggttatcagc gaacggtatg
     3301 gggattctgg cgctggccaa ccacggccag aacccggact ttcctggtct ggtcatcaac
     3361 atcatacagg acatgctgtc ccatcagact gatccggcga acgtcctcgc catagcgtga
     3421 gtccacttca tagaggcgcg ggaagtcggc cagtttgtcc gccgcagtga gaacgcgatc
     3481 ggtaacgttc tgcgcatccc acagggatga attttccgcg atatagtcaa acagcatcgt
     3541 tacatcctcg atggctccct gtttccattc cacatcatac ggcatcgcgc agttcctgat
     3601 aacggccatg caggcgctgg cggagttgtt ccgtggtcat gcccggacgc gtgtcagcac
     3661 gggcggcggt tactttggcg cgaacctgat cttcatactc tgcctgggcc agttcttcgt
     3721 tagccaggcg ttgcaacaac gcagctttgt ccgggtcact ttccggcagt atgcggggca
     3781 ggttttcagc cagttcccgc aggaagttgg cgttttcgta gtgtgtagtg ttgctcattg
     3841 cggaggctcc cggattaatg cggtgatatg aagaagttta gcagggggcg gtctgaaaga
     3901 atatggtcgt gtcagtcagg ctgatgaagc agaaagtcgg taaaaaaagg gcttacggca
     3961 tccattttac gtcaaaacat atgctatgca gttgcgtgca taggcatgca ttaggataaa
     4021 gtttaccggg cgcgtttccg gcggttttcc gggtgatttg ttgcctgttt tatcccgtag
     4081 ccgccggaaa cgctctgagg gcctctcagg cggtgctgat aacgggtttt atggtaaatg
     4141 gctggttatg aggcattcag ctgacgattt ttgcgtcaac ttttcgctgt atgtttaaac
     4201 atgagtttaa cattagcgtc atctgatagc gctgttgcta atttcatcga cccgacaggt
     4261 aatttccttg taaatcaagc gcgaaagatc agcaaaaaag ctatgtgtgc gcttatggaa
     4321 taaggtagaa taagggattc tgatgatcgt gaggttgtca gtgaaaaacg aggcagctat
     4381 cagatcttcg gcctgagaaa ctaaggattc tgatagctgc cggtgactca gttcgtgaaa
     4441 actgaatctt acctgatcaa caaacgcccg attagggcgt ttgtcaagtg gtgctgcatt
     4501 atgtagtaac ttggtaccga cttgccaggc atttttcaca gttttttgat gtgcgaatgc
     4561 tcatccggac accgtcacct gttatttatc ctctgtaaac aggtgctata aatgcaaaaa
     4621 gtaactgatc tgtatcctcc tgaaattgct cgccataagc tccagaatca cttcgccggt
     4681 aataccgtta tgctggagtt aatccagaaa ctaaataaaa ccagcctgtg tacttttgcg
     4741 gcgctctgtg acggcaacgt agtgaccact tccggctata acatcacggc cgatctatgt
     4801 gttaaccgtg cgtcagccgt ggcccattcg cttaagcaaa aatatctgcc agttacggcc
     4861 agaacgattt cgacaaaggc tgatgtaggt ggtgcggtaa agcaggcggc tttctgtatc
     4921 gatgaggacg atcttgcaag gctgaaatca gagccggaaa agatgatgaa agagtgcgaa
     4981 cgtaacctga acagccagaa gcgcaccaat gctcagaagg aaatgagccg gttgtacaag
     5041 gagtttggtg aagacggcat actggcgctg ttacgcaatg ttgcccagtc gaacggtaca
     5101 ccgccgccag gcgcacaccc tgcaagttga taccagtaaa gcccctaagg ggctttattt
     5161 ttaaggtttt ctggatgccg ccagctcttg atctgtcagc taatcgcggt gcagatagtt
     5221 cccttctacc ggcggtggcg ttaccagttt tgcttttcct tctttcggac gagaatttca
     5281 ctcttaccgt acattttcgt acggttggac ctcgaacccc tttcaggccc atggccagtg
     5341 cctgagcgac aaaggcgtcc gccaggcgct tttcttcagg tgcgtcatgg tggcctccgg
     5401 gttgtctccg attcctgaac agtttaaccg caggtactct cctcatgcca tttcgctttc
     5461 aggtacatct ataccaatat aaaagtaagt gtgatgaatg tctcaaataa taaaatttgt
     5521 tgccatgaga aattttcggg aaaagacgcg atctgcttac aggcggctcc gggcgctttt
     5581 ttgtgcctga agatgagaac taatctcata tattgacacc tgaaaactgg aggagtaagg
     5641 taacaattat actgtgtata tatacagtat attggtttta atttattgtt ttaaatgtca
     5701 aagaggaaaa cgatatgagt ggtggagacg gtcgaggtcc gggtaattca ggtctgggac
     5761 ataatggtgg tcaggccagt gggaatgtga acggtacgtc tggtaaaggt ggcccttcat
     5821 caggtggtgg tacggatcca aacagcgggc cgggctgggg tacgacgcat acgccgaatg
     5881 gagatattca taactataat ccgggggagt ttggtaacgg cgggagtaaa cccggtggta
     5941 atggtggtaa cagcggcaat catagcggta gctctggtgg cggacagtct tcggccactg
     6001 cgatggcctt cggtctgcct gccctggcta ctccgggggc tgaaggactg gctttatcag
     6061 tttccggcga tgcgttgtcg gccgccgttg ctgatgtgct ggctgccctg aaggggccgt
     6121 ttaagtttgg tctgtggggg attgcgatct acggtgtgct gccttctgag attgcaaaag
     6181 atgatccgaa aatgatgtca aaaattatga cgtcattacc ggccgatgcg gtgacggaga
     6241 ctccggcaag tactttacca ctggaccagg cgacggttcg tgtcagacaa cgggttgtgg
     6301 atgtggtgaa ggatgagcgg cagcatattg cggttgtcgc aggtcggcca atgagtgtcc
     6361 ctgtggtgga tgcgaaaccg acaaaacgtc cgggggtatt cagtgtgtcg attccgggtc
     6421 tcccgtctct gcaggtgaac gtaccgaaag gtgttccgac agcgaaagcc ccgccaaaag
     6481 gcattgttgc tgaaaaaggt gattcacgtc cggctggttt tacagccggt ggtaactccc
     6541 gtgaggccgt tattcgtttc ccgaaagaga ccggacagaa gccggtttat gtgtcggtga
     6601 cagatgttct taccccggca caggtaaaac agcgtcagga ggaagaaaag cgtcgccagc
     6661 aggcatggga cgccgctcat ccggaagagg ggctgaaaag agactatgat aaagcgaaag
     6721 ctgagctgga tgccgaagat aaaaatattg cgaccttaaa cagccgcatt gcatcgacag
     6781 agaaggcgct ccccggtgca agggctgctg ttcaggaagc cgataaaaag gtaaaagagg
     6841 cagaggcaaa taaagatgat tttgtgactt ataacccgcc tcatgaatat ggctccgggt
     6901 ggcaggatca ggttcgctat cttgataagg atattcagaa tcagaatgag aaattaaaag
     6961 cggctcaggc atctttaaac gcaatgaatg aatccttatc cagagataag gctgcactta
     7021 ccggggcgat ggagagccgg aaacaaaagg agaaaaaagc gaaggatgca gaaaataagt
     7081 taaatgagga aaagaacaag cctcgcaagg gagttaaaga ttacggtcat gattatcatc
     7141 ccgctccgaa gaccgaagaa atcaaggggt tgggggaatt aaaaaaagca cctaaaaaaa
     7201 cacctaaaca gggtggtggt ggtagacgtg accgttggat tggtgataaa ggccgtaaga
     7261 tttatgaatg ggactcccag cacggtgagc ttgaagggta tcgtgccagt gatggcgaac
     7321 acctcggggc atttgatcca aaaacgggta agcaaattaa aggtccggat ccgaaaggac
     7381 gaaacattaa aaaatatctt tgagaggtaa gtatggggct taaattaaat ttaacctggt
     7441 ttgataagaa gactgaggaa tttattggtg aggagtattc taaagacttt ggtgatgatg
     7501 gttctgtcat tgaaagcctt ggaatgcctt taaaggataa tattaacaat ggcgggtttg
     7561 atgttgagaa atcatgggtt ccgttgttgc agccatattt taaaaataaa attgaagtcg
     7621 ataagtactg gtatcaaatt tcatttgatt atcgggacgg taactggtaa caaaaaatta
     7681 tcaaggatga tttgaaatac agacttccgg tgttcaggga tgaatgccgg ggtttttaaa
     7741 tacagggaag gtatatgaaa aaggtaaagg ttgtttttct ttttatattg atttttttag
     7801 gctttcttct ggtcgcatgt caggcaaact atatccggga tgttcagggt ggaacggtgg
     7861 caccatcgtc ctcctctgaa ctgacgggga tcgcggttca gtagaaaaga tcaaaggatc
     7921 ttcttgagat cctttttttc tgcgcgtaat cttttgccct gtaaacgaaa aaaccacctg
     7981 gggaggtggt ttgatcgaag gttaagtcag ttggggaact gcttaaccgt ggtaactggc
     8041 tttcgcagag cacagcaacc aaatctgtcc ttccagtgta gccggacttt ggcgcacact
     8101 tcaagagcaa ccgcgtgttt agctaaacaa atcctctgcg aactcccagt taccaatggc
     8161 tgctgccagt ggcgttttgc gtgcttttcc gggttggact caagtgaaca gttaccggat
     8221 aaggcgcagc agtcgggctg aacggggagt tcttgcttac agcccagctt ggagcgaacg
     8281 acctacaccg agccgagata ccagtgtgtg agctatgaga aagcgccaca cttcccgcaa
     8341 gggagaaagg cggacaggta tccggtaaac ggcagggtcg gaacaggaga gcgcaagagg
     8401 gagcgaccta ccggaaacgg tggggatctt taagtcctgt cgggtttcgc ccgtactgtc
     8461 agattcatgg ttgagcctca cggctcccac agatgcaccg aaaaagcgtc tgtttatgtg
     8521 aactctggca ggagggcgga gcctatggaa aaacgccacc ggcgcggccc tgccgttttg
     8581 cctcacatgt tagtcccctg cttatccacg gaatctgtgg gtaactttgt atgtgtccgc
     8641 agcgcccgcc gcagtctcac gcccggagcg tagcgaccga gtgagcgagg aggcgcaatt
     8701 tccccggcac ctgcaagacg gtcaccggac gcgctgatgt gggatattgt cccctgatta
     8761 agtctttcta ttccctgacg atcaattatc aggataggtg aaccatgtcg gtttttcgct
     8821 gaacatttta cgttaaccta tctctgttgc ttttttctcc ttacggagaa atgcaagtca
     8881 tccccgctag ggcgtggctg acttcagggg gaaatcccct gcttacgctg gctggacgcc
     8941 ggccacgcca gaaattcacc tggcccccgt caggctcacg cctgaccacc cacaaaaatc
     9001 cacggtgctg aacgcacctg acgaagcagc aaagctgctc ctgattttgc gggtggtcag
     9061 ccgctcgcta tggcgaactc tgacgggggc cggaacaccg gaaaagaccg cactggggtg
     9121 ctgccttttc ctctcacacg ctggggcgtg ctcgttgttc ctccggggct gcgccttttc
     9181 cgcatggggc ggaaagaggc tggcctccgc ggtgaaagct gaacgcaatc accacggacg
     9241 tgaccgccgc cgccatgcct tggggcatgt ccgcggcttg tgcagcaggg gctgcacaac
     9301 acgccggtaa acccgtcgtc tgaaggagag agattgcatg tttaatacgg attcgcttgc
     9361 ctggcagtgg catatcccgg agctggcccg gcagatttac ccgtgggtca gctggctgta
     9421 ccgggagtat tacggtctgg ccggggcttt tctggttatc ggcctgtttt tcggtctggc
     9481 tgaactctgg gccggacgga tgcgttttgt ggggctgagt cataaggagc ggcgggagta
     9541 tgccgatcgc tataagcgcg ataataaccg gactgcgcca ttttcggtgc tggcctcgct
     9601 ggattcgccc gggcggatgg tcagggttcg gcggcatgtc tggaactacg cgtactggct
     9661 gaccggcgct gccggtctgg cccttctggg ggggcttgtt gtcgccgtgt ttatcgagag
     9721 ctggggagaa accgtcctgc gtccggacct ctacgcgaac gcagattatt acctgctgca
     9781 gccggctaac ctgttcggga ttacctggtg cgcgggcggg ctggttgtcg ggattgtgtt
     9841 ggcgcggctg ctggcgttcc tgctgcttga cggtcatttt gcggccgctg acgaggcggt
     9901 gaacgcgaaa ctgaaccagg agagccggcg cagcagccag cggaccggtg aaatgaccga
     9961 cgtccgccac ctgcatttcg gggagccggt accggt
//
