LOCUS       NZ_CP095432            27281 bp    DNA     circular CON 20-MAY-2024
DEFINITION  Klebsiella pneumoniae strain IM007 plasmid pIM007_4, complete
            sequence.
ACCESSION   NZ_CP095432
VERSION     NZ_CP095432.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN27398041
            Assembly: GCF_027942215.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 27281)
  AUTHORS   Tang,N., Li,Y., Yao,S., Hu,J., Zhao,Y., Fu,S., Song,Y., Wang,C.,
            Zhang,G., Wei,D., Li,C., Jia,R. and Feng,J.
  TITLE     Epidemicity and clonal replacement of hypervirulent
            carbapenem-resistant Klebsiella pneumoniae with diverse pathotypes
            and resistance profiles in a hospital
  JOURNAL   J Glob Antimicrob Resist 32, 4-10 (2023)
   PUBMED   36400407
REFERENCE   2  (bases 1 to 27281)
  AUTHORS   Tang,N.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-APR-2022) State Key Laboratory of Microbial Resources,
            Institute of Microbiology, Chinese Academy of Sciences, No.1 Beichen
            West Road, Beijing 100000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Flye v. 2.6
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 200X
            Sequencing Technology             :: Oxford Nanopore PromethION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_027942215.1-RS_2024_05_20
            Annotation Date                   :: 05/20/2024 05:06:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,087
            CDSs (total)                      :: 5,965
            Genes (coding)                    :: 5,736
            CDSs (with protein)               :: 5,736
            Genes (RNA)                       :: 122
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 85
            ncRNAs                            :: 12
            Pseudo Genes (total)              :: 229
            CDSs (without protein)            :: 229
            Pseudo Genes (ambiguous residues) :: 0 of 229
            Pseudo Genes (frameshifted)       :: 90 of 229
            Pseudo Genes (incomplete)         :: 147 of 229
            Pseudo Genes (internal stop)      :: 29 of 229
            Pseudo Genes (multiple problems)  :: 35 of 229
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP095432.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..27281
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="IM007"
                     /isolation_source="sputum"
                     /host="patient"
                     /db_xref="taxon:573"
                     /plasmid="pIM007_4"
                     /geo_loc_name="China"
                     /collection_date="2019-01-24"
     gene            join(27202..27281,1..76)
                     /locus_tag="MWR71_RS30180"
                     /old_locus_tag="MWR71_30135"
     CDS             join(27202..27281,1..76)
                     /locus_tag="MWR71_RS30180"
                     /old_locus_tag="MWR71_30135"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_271237406.1"
                     /translation="MNEAESGTVGITAAILTCPVPELPEDNDYHPVPKTEDIKGLGELK
                     RGDPKT"
                     /name="hypothetical protein"
     gene            88..180
                     /locus_tag="MWR71_RS30185"
                     /old_locus_tag="MWR71_30140"
     CDS             88..180
                     /locus_tag="MWR71_RS30185"
                     /old_locus_tag="MWR71_30140"
                     /inference="COORDINATES: protein motif:HMM:NF020569.4"
                     /GO_function="GO:0016788 - hydrolase activity, acting on
                     ester bonds [Evidence IEA]; GO:0043022 - ribosome binding
                     [Evidence IEA]; GO:0003723 - RNA binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin E3/pyocin S6 family cytotoxin"
                     /protein_id="WP_271237407.1"
                     /translation="MVKPGRWYGDKRTEIEWDSQHGEQKEYRAQ"
                     /name="colicin E3/pyocin S6 family cytotoxin"
     gene            3608..>3916
                     /locus_tag="MWR71_RS30190"
                     /pseudo=""
     CDS             3608..>3916
                     /locus_tag="MWR71_RS30190"
                     /inference="COORDINATES: protein motif:HMM:NF024108.4"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="Mobilization protein A"
                     /name="Mobilization protein A"
     gene            4167..4897
                     /gene="mobC"
                     /locus_tag="MWR71_RS30195"
                     /old_locus_tag="MWR71_30150"
                     /pseudo=""
     CDS             4167..4897
                     /gene="mobC"
                     /locus_tag="MWR71_RS30195"
                     /old_locus_tag="MWR71_30150"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146447.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="MobC family replication-relaxation protein"
                     /name="mobC"
     gene            4904..5434
                     /locus_tag="MWR71_RS30200"
                     /old_locus_tag="MWR71_30155"
     CDS             4904..5434
                     /locus_tag="MWR71_RS30200"
                     /old_locus_tag="MWR71_30155"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_071177729.1"
                     /translation="MALYMVFIEDVEDKDGERCIMPTSEHLEDMVVLAWQTGAYVFCFV
                     DRAQHLAMMKSIGMYDERLNSDEKATYFFTGENPQWERDKPTGMKLCDYLYRKVERFAI
                     ENGVQVVDAGKCSPEQINAMIEVVSERHGESAVNEKLKAELMREYNSRYFNVPVPELPE
                     DKPARRWWPFGKK"
                     /name="hypothetical protein"
     gene            complement(5461..5640)
                     /locus_tag="MWR71_RS30205"
                     /old_locus_tag="MWR71_30160"
     CDS             complement(5461..5640)
                     /locus_tag="MWR71_RS30205"
                     /old_locus_tag="MWR71_30160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rop family plasmid primer RNA-binding protein"
                     /protein_id="WP_000165970.1"
                     /translation="MTKQEKTALNMAKFIKDQSLLLLEKLNELDMDTPADMCERLHEDA
                     ETLWQVMRDKLGEE"
                     /name="Rop family plasmid primer RNA-binding protein"
     gene            complement(5666..6094)
                     /locus_tag="MWR71_RS30210"
                     /old_locus_tag="MWR71_30165"
     CDS             complement(5666..6094)
                     /locus_tag="MWR71_RS30210"
                     /old_locus_tag="MWR71_30165"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001140599.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001140599.1"
                     /translation="MAKTLLNLSQAAQAAGITRRTLYNHVKQGKVTVSRDGKNNPVVDV
                     SELIRVYGNVNIPEKQIPGISHRENTQKNFPQEQLLAMQKELADLRQAVTLMLEDKTSR
                     EEERRQHDDERRKLQAEVDRLTTELTQKKKRFWSGWFS"
                     /name="hypothetical protein"
     gene            complement(6258..6572)
                     /locus_tag="MWR71_RS30215"
                     /old_locus_tag="MWR71_30170"
     CDS             complement(6258..6572)
                     /locus_tag="MWR71_RS30215"
                     /old_locus_tag="MWR71_30170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001136729.1"
                     /GO_function="GO:0008657 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) inhibitor activity
                     [Evidence IEA]; GO:0042803 - protein homodimerization
                     activity [Evidence IEA]"
                     /GO_process="GO:0030541 - plasmid partitioning [Evidence
                     IEA]; GO:0051290 - protein heterotetramerization [Evidence
                     IEA]; GO:0009432 - SOS response [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_071177730.1"
                     /translation="MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKT
                     LPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDREMDQIVIVTVRHQKESGYPGADSL
                     "
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            complement(6560..6839)
                     /locus_tag="MWR71_RS30220"
                     /old_locus_tag="MWR71_30175"
                     /pseudo=""
     CDS             complement(6560..6839)
                     /locus_tag="MWR71_RS30220"
                     /old_locus_tag="MWR71_30175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014542884.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="CopG family ribbon-helix-helix protein"
                     /name="CopG family ribbon-helix-helix protein"
     gene            complement(7015..7380)
                     /locus_tag="MWR71_RS30225"
                     /old_locus_tag="MWR71_30180"
     CDS             complement(7015..7380)
                     /locus_tag="MWR71_RS30225"
                     /old_locus_tag="MWR71_30180"
                     /inference="COORDINATES: protein motif:HMM:TIGR01352.1"
                     /GO_function="GO:0015291 - secondary active transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TonB family protein"
                     /protein_id="WP_072354022.1"
                     /translation="MKAFTLTVLAAMFLTPVHAIPLKPVTTLQPTYPVQAAAKRIEGQV
                     TATFDILDDGRVDNVSLTGCHLFFRETLTAMRHWLYPAGHPAMRQVINFEFSLKNDGLQ
                     DPRPVTTQKLNDDGCRQ"
                     /name="TonB family protein"
     gene            complement(7377..7748)
                     /gene="tolA"
                     /locus_tag="MWR71_RS30230"
                     /old_locus_tag="MWR71_30185"
     CDS             complement(7377..7748)
                     /gene="tolA"
                     /locus_tag="MWR71_RS30230"
                     /old_locus_tag="MWR71_30185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001237044.1"
                     /GO_component="GO:0098567 - periplasmic side of plasma
                     membrane [Evidence IEA]"
                     /GO_function="GO:0005215 - transporter activity [Evidence
                     IEA]"
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell envelope integrity protein TolA"
                     /protein_id="WP_001237044.1"
                     /translation="MRLIPFILLALCSPLLLTACKHSTTQPPKIYTLDKSSKISSYAAA
                     IKTAVEMQMFEPEAYAGKMCTVRISIQRDGTLNSAIAEGGDPKLCKAAISAVTHAKIPP
                     APDENTWQIFKNAPLDFRP"
                     /name="tolA"
     gene            8375..9862
                     /gene="ltrA"
                     /locus_tag="MWR71_RS30235"
                     /old_locus_tag="MWR71_30190"
                     /pseudo=""
     CDS             8375..9862
                     /gene="ltrA"
                     /locus_tag="MWR71_RS30235"
                     /old_locus_tag="MWR71_30190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_005226014.1"
                     /GO_function="GO:0003964 - RNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0000373 - Group II intron splicing
                     [Evidence IEA]"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="group II intron reverse transcriptase/maturase"
                     /name="ltrA"
     gene            <9912..10985
                     /locus_tag="MWR71_RS30240"
                     /old_locus_tag="MWR71_30195"
                     /pseudo=""
     CDS             <9912..10985
                     /locus_tag="MWR71_RS30240"
                     /old_locus_tag="MWR71_30195"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000012966.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="colicin-like bacteriocin tRNase domain-containing
                     protein"
                     /name="colicin-like bacteriocin tRNase domain-containing
                     protein"
     gene            10995..11252
                     /locus_tag="MWR71_RS30245"
                     /old_locus_tag="MWR71_30200"
     CDS             10995..11252
                     /locus_tag="MWR71_RS30245"
                     /old_locus_tag="MWR71_30200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891189.1"
                     /GO_function="GO:0015643 - toxic substance binding
                     [Evidence IEA]"
                     /GO_process="GO:0030153 - bacteriocin immunity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin E3-like toxin immunity protein"
                     /protein_id="WP_032440455.1"
                     /translation="MGLKLRLTWFDKKTEEFKGEEYSKDFGDDGSVIESLGMPLKDNIN
                     NGEFDLKKEWVPLLQPFFKNQIKPDVDNCYIAFDYRDGNW"
                     /name="colicin E3-like toxin immunity protein"
     gene            11337..11486
                     /locus_tag="MWR71_RS30250"
                     /old_locus_tag="MWR71_30205"
     CDS             11337..11486
                     /locus_tag="MWR71_RS30250"
                     /old_locus_tag="MWR71_30205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891188.1"
                     /GO_component="GO:0019867 - outer membrane [Evidence IEA]"
                     /GO_process="GO:0019835 - cytolysis [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin release lysis protein"
                     /protein_id="WP_032440454.1"
                     /translation="MKKVKTIFLFILIVAGFLLAACQANYIRDVQGGTVAPSSSSELTG
                     IAVQ"
                     /name="colicin release lysis protein"
     gene            12970..14934
                     /locus_tag="MWR71_RS30255"
                     /old_locus_tag="MWR71_30210"
     CDS             12970..14934
                     /locus_tag="MWR71_RS30255"
                     /old_locus_tag="MWR71_30210"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004178196.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TraM recognition domain-containing protein"
                     /protein_id="WP_071177727.1"
                     /translation="MFNTDSLAWQWHIPELARQIYPWVSWLYREYYSLAGFFLVIGLFF
                     GLAELWAGRMRFVGLSHKARREYADRYKRDNNRTVPFSVLASLDSPGRMVRARRHVWNY
                     AYWLTGAAGLALLGGLVVAVFIESWGETVLRPDLYANADYYLLQPANLFGIAWCAGGLV
                     AGVLLARLLAFLLLDGHFAAADEAVNAKLNQESRRSSQRTGEMTDVRHLHFGEPVPVNA
                     LADFSTEQARKQQAVFLGKDEQGQPVLVPRDTWRKTNIQILGLPGSGKSAMATNALIRC
                     VRDFGDAVVYFDPKGDAWAPHVFRAHCPDFTLLDLRPGKPAQLNLFRDLDQYALKNLLV
                     AGFNLSETGDVADHYRISEQKAAKLIAEQFPQGANIQQVLAAAYALPEALKKDVKGLIT
                     KLENVADLSVLQTDSGIDVAGIINGGGCLYVIGSMDDEAVIRVQKMLFARCAQIIIARD
                     EFRRWPHASIMLDEIKYLLSKYVLNALGTLRSRDCNLLLAHQSLGDFGQCGQDLPADFV
                     KTTVLDNTPIRWFYRAASQESAQWAAGQTGEIRVDVERRRASREAGNVEHISGDSFIQK
                     EARPLFDVNTLQHLPDGFAVMTGLGVARLAFSSPLRVERREISLKTFPVLAKTDPLAEY
                     LPPADGGGPKADDDFAGLY"
                     /name="TraM recognition domain-containing protein"
     gene            14934..15665
                     /gene="mobC"
                     /locus_tag="MWR71_RS30260"
                     /old_locus_tag="MWR71_30215"
     CDS             14934..15665
                     /gene="mobC"
                     /locus_tag="MWR71_RS30260"
                     /old_locus_tag="MWR71_30215"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobC family replication-relaxation protein"
                     /protein_id="WP_071177728.1"
                     /translation="MTLEQYNVSHAKRQARNAEKTRLTLRWLREELCSTAELVARRLGI
                     AAVQPVYRFLDSLVAKGLLVRAKYPVDGRQVSVWGLTPHGVAFSFDEDEPLTDVIPFQP
                     SRVSAAQLPHRLAVQSLRLSMEGRGATGWRYLHRMALKGMKVPDALAELDGRTVAFEVE
                     RTVKSRRRYQEVVSGYLFNRRANGIDEIWYICPDRPTLVRVQRAILAVDEIVNPQTGEA
                     RKTVELDRERLFACFKFMTTE"
                     /name="mobC"
     gene            15672..16202
                     /locus_tag="MWR71_RS30265"
                     /old_locus_tag="MWR71_30220"
     CDS             15672..16202
                     /locus_tag="MWR71_RS30265"
                     /old_locus_tag="MWR71_30220"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_071177729.1"
                     /translation="MALYMVFIEDVEDKDGERCIMPTSEHLEDMVVLAWQTGAYVFCFV
                     DRAQHLAMMKSIGMYDERLNSDEKATYFFTGENPQWERDKPTGMKLCDYLYRKVERFAI
                     ENGVQVVDAGKCSPEQINAMIEVVSERHGESAVNEKLKAELMREYNSRYFNVPVPELPE
                     DKPARRWWPFGKK"
                     /name="hypothetical protein"
     gene            complement(16229..16408)
                     /locus_tag="MWR71_RS30270"
                     /old_locus_tag="MWR71_30225"
     CDS             complement(16229..16408)
                     /locus_tag="MWR71_RS30270"
                     /old_locus_tag="MWR71_30225"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rop family plasmid primer RNA-binding protein"
                     /protein_id="WP_000165970.1"
                     /translation="MTKQEKTALNMAKFIKDQSLLLLEKLNELDMDTPADMCERLHEDA
                     ETLWQVMRDKLGEE"
                     /name="Rop family plasmid primer RNA-binding protein"
     gene            complement(16434..16862)
                     /locus_tag="MWR71_RS30275"
                     /old_locus_tag="MWR71_30230"
     CDS             complement(16434..16862)
                     /locus_tag="MWR71_RS30275"
                     /old_locus_tag="MWR71_30230"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001140599.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001140599.1"
                     /translation="MAKTLLNLSQAAQAAGITRRTLYNHVKQGKVTVSRDGKNNPVVDV
                     SELIRVYGNVNIPEKQIPGISHRENTQKNFPQEQLLAMQKELADLRQAVTLMLEDKTSR
                     EEERRQHDDERRKLQAEVDRLTTELTQKKKRFWSGWFS"
                     /name="hypothetical protein"
     gene            complement(17026..17340)
                     /locus_tag="MWR71_RS30280"
                     /old_locus_tag="MWR71_30235"
     CDS             complement(17026..17340)
                     /locus_tag="MWR71_RS30280"
                     /old_locus_tag="MWR71_30235"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001136729.1"
                     /GO_function="GO:0008657 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) inhibitor activity
                     [Evidence IEA]; GO:0042803 - protein homodimerization
                     activity [Evidence IEA]"
                     /GO_process="GO:0030541 - plasmid partitioning [Evidence
                     IEA]; GO:0051290 - protein heterotetramerization [Evidence
                     IEA]; GO:0009432 - SOS response [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_071177730.1"
                     /translation="MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKT
                     LPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDREMDQIVIVTVRHQKESGYPGADSL
                     "
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            complement(17328..17606)
                     /locus_tag="MWR71_RS30285"
                     /old_locus_tag="MWR71_30240"
     CDS             complement(17328..17606)
                     /locus_tag="MWR71_RS30285"
                     /old_locus_tag="MWR71_30240"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014542884.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CopG family ribbon-helix-helix protein"
                     /protein_id="WP_000093040.1"
                     /translation="MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEK
                     RSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWGTENEQDAPPCHR"
                     /name="CopG family ribbon-helix-helix protein"
     gene            complement(17781..18146)
                     /locus_tag="MWR71_RS30290"
                     /old_locus_tag="MWR71_30245"
     CDS             complement(17781..18146)
                     /locus_tag="MWR71_RS30290"
                     /old_locus_tag="MWR71_30245"
                     /inference="COORDINATES: protein motif:HMM:TIGR01352.1"
                     /GO_function="GO:0015291 - secondary active transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TonB family protein"
                     /protein_id="WP_072354022.1"
                     /translation="MKAFTLTVLAAMFLTPVHAIPLKPVTTLQPTYPVQAAAKRIEGQV
                     TATFDILDDGRVDNVSLTGCHLFFRETLTAMRHWLYPAGHPAMRQVINFEFSLKNDGLQ
                     DPRPVTTQKLNDDGCRQ"
                     /name="TonB family protein"
     gene            complement(18143..18514)
                     /gene="tolA"
                     /locus_tag="MWR71_RS30295"
                     /old_locus_tag="MWR71_30250"
     CDS             complement(18143..18514)
                     /gene="tolA"
                     /locus_tag="MWR71_RS30295"
                     /old_locus_tag="MWR71_30250"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001237044.1"
                     /GO_component="GO:0098567 - periplasmic side of plasma
                     membrane [Evidence IEA]"
                     /GO_function="GO:0005215 - transporter activity [Evidence
                     IEA]"
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell envelope integrity protein TolA"
                     /protein_id="WP_001237044.1"
                     /translation="MRLIPFILLALCSPLLLTACKHSTTQPPKIYTLDKSSKISSYAAA
                     IKTAVEMQMFEPEAYAGKMCTVRISIQRDGTLNSAIAEGGDPKLCKAAISAVTHAKIPP
                     APDENTWQIFKNAPLDFRP"
                     /name="tolA"
     gene            complement(18788..19033)
                     /locus_tag="MWR71_RS30300"
                     /old_locus_tag="MWR71_30255"
     CDS             complement(18788..19033)
                     /locus_tag="MWR71_RS30300"
                     /old_locus_tag="MWR71_30255"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146442.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_032440458.1"
                     /translation="MTHLKLTPAEEKRLADAFVAQALAMGLKGNKTLPKAVKQQVRERV
                     LRAIQDEREARRAQEMRREKYEATETTFTWQPQRRR"
                     /name="hypothetical protein"
     gene            19678..21167
                     /gene="ltrA"
                     /locus_tag="MWR71_RS30305"
                     /old_locus_tag="MWR71_30260"
                     /pseudo=""
     CDS             19678..21167
                     /gene="ltrA"
                     /locus_tag="MWR71_RS30305"
                     /old_locus_tag="MWR71_30260"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_005226014.1"
                     /GO_function="GO:0003964 - RNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0000373 - Group II intron splicing
                     [Evidence IEA]"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="group II intron reverse transcriptase/maturase"
                     /name="ltrA"
     gene            21160..21903
                     /locus_tag="MWR71_RS30310"
                     /old_locus_tag="MWR71_30265"
     CDS             21160..21903
                     /locus_tag="MWR71_RS30310"
                     /old_locus_tag="MWR71_30265"
                     /inference="COORDINATES: protein motif:HMM:NF023002.4"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin-like bacteriocin tRNase domain-containing
                     protein"
                     /protein_id="WP_271237397.1"
                     /translation="MRKSRTPGSVRGVSGNGYPYRIVAEKGDSRPAGFTAGGNSREAVI
                     RFPKETGQKPVYVSVTDVLTPAQVKQRQEEEKRRQQAWDAAHPEEGLKRDYDKAKAELD
                     AEDKNIATLNSRIASTEKALPGARAAVQEADKKVKEAEANKDDFVTYNPPHEYGSGWQD
                     QVRYLDKDIQNQNEKLKAAQASLNAMNESLSRDKAALTGAMESRKQKEKKAKDAENKLN
                     EEKNKPRKGLKTTAMIIIQYLKQKT"
                     /name="colicin-like bacteriocin tRNase domain-containing
                     protein"
     gene            <21995..22138
                     /locus_tag="MWR71_RS30315"
                     /old_locus_tag="MWR71_30270"
                     /pseudo=""
     CDS             <21995..22138
                     /locus_tag="MWR71_RS30315"
                     /old_locus_tag="MWR71_30270"
                     /inference="COORDINATES: protein motif:HMM:NF020569.4"
                     /GO_function="GO:0016788 - hydrolase activity, acting on
                     ester bonds [Evidence IEA]; GO:0043022 - ribosome binding
                     [Evidence IEA]; GO:0003723 - RNA binding [Evidence IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="colicin E3/pyocin S6 family cytotoxin"
                     /name="colicin E3/pyocin S6 family cytotoxin"
     gene            22148..22404
                     /locus_tag="MWR71_RS30320"
                     /old_locus_tag="MWR71_30275"
                     /pseudo=""
     CDS             22148..22404
                     /locus_tag="MWR71_RS30320"
                     /old_locus_tag="MWR71_30275"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891189.1"
                     /GO_function="GO:0015643 - toxic substance binding
                     [Evidence IEA]"
                     /GO_process="GO:0030153 - bacteriocin immunity [Evidence
                     IEA]"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="colicin E3-like toxin immunity protein"
                     /name="colicin E3-like toxin immunity protein"
     gene            22489..22638
                     /locus_tag="MWR71_RS30325"
                     /old_locus_tag="MWR71_30280"
     CDS             22489..22638
                     /locus_tag="MWR71_RS30325"
                     /old_locus_tag="MWR71_30280"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891188.1"
                     /GO_component="GO:0019867 - outer membrane [Evidence IEA]"
                     /GO_process="GO:0019835 - cytolysis [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin release lysis protein"
                     /protein_id="WP_032440454.1"
                     /translation="MKKVKTIFLFILIVAGFLLAACQANYIRDVQGGTVAPSSSSELTG
                     IAVQ"
                     /name="colicin release lysis protein"
     gene            24118..24294
                     /locus_tag="MWR71_RS30330"
                     /old_locus_tag="MWR71_30285"
     CDS             24118..24294
                     /locus_tag="MWR71_RS30330"
                     /old_locus_tag="MWR71_30285"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_271237398.1"
                     /translation="MFNTDSLAWQWHIPELARQIYPWVSWLYRGITVWPVFLVIGLFFG
                     LAELWAGRMRFWG"
                     /name="hypothetical protein"
     gene            24724..25146
                     /locus_tag="MWR71_RS30335"
                     /old_locus_tag="MWR71_30290"
     CDS             24724..25146
                     /locus_tag="MWR71_RS30335"
                     /old_locus_tag="MWR71_30290"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_271237399.1"
                     /translation="MTDVRHLHFGEPVPVNALADFSTEQARKQQAVFLGKDEQGQPVLV
                     PRDTWRKTNIQILGLPGSGKSAMATNALIRCVRDFGDAVVYFDPKGDAWAPHVFRAHCR
                     TSPCWICGRETGAAESVPRSRPVRPEESAGCRVLTW"
                     /name="hypothetical protein"
     gene            25157..25648
                     /locus_tag="MWR71_RS30340"
                     /old_locus_tag="MWR71_30295"
     CDS             25157..25648
                     /locus_tag="MWR71_RS30340"
                     /old_locus_tag="MWR71_30295"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_271237400.1"
                     /translation="MADHYRISEQKAAKLIAEQFPQGANIQQVLAAAYALPEALKKDVK
                     GLITKLENVADLSVLQTDSGIDVAGIINGGGCLYVIGSMDDEAVIRVQKMLFARCAQII
                     IARDEFRRWPHASIMLDEIKYLLSKYVLNAGDAAQPGLQPAARAPVAGRLRSVRAGSAR
                     "
                     /name="hypothetical protein"
     gene            25653..25853
                     /locus_tag="MWR71_RS30345"
                     /old_locus_tag="MWR71_30300"
     CDS             25653..25853
                     /locus_tag="MWR71_RS30345"
                     /old_locus_tag="MWR71_30300"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_271237401.1"
                     /translation="MKTTVLDNTPIRWFYRAASQESAQWAAGQTGRSGWTWSAAASREA
                     GNVEHISGDSFIRRRRGRCLT"
                     /name="hypothetical protein"
     gene            26066..26821
                     /gene="mobC"
                     /locus_tag="MWR71_RS30480"
                     /pseudo=""
     CDS             26066..26821
                     /gene="mobC"
                     /locus_tag="MWR71_RS30480"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146447.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="MobC family replication-relaxation protein"
                     /name="mobC"
     gene            26796..26954
                     /locus_tag="MWR71_RS30360"
                     /old_locus_tag="MWR71_30315"
     CDS             26796..26954
                     /locus_tag="MWR71_RS30360"
                     /old_locus_tag="MWR71_30315"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_271237404.1"
                     /translation="MALYMVFIEDVEDKDGERCIMPTSEHLEDMVVLAWQTRRMFSVCR
                     PEPSIWR"
                     /name="hypothetical protein"
     gene            26951..27127
                     /locus_tag="MWR71_RS30365"
                     /old_locus_tag="MWR71_30320"
     CDS             26951..27127
                     /locus_tag="MWR71_RS30365"
                     /old_locus_tag="MWR71_30320"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_271237405.1"
                     /translation="MMKSIGMYDDGSTATKKSHMLFTGENPQWEQDKPTGMTVRLLSSK
                     VERFAIGNSVPGG"
                     /name="hypothetical protein"
     BGC             4936..26903
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          complement(858..1419)
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="91.141"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(11590..12168)
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="98.282"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(22742..23323)
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="93.504"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          4168..4751
                     /name="MOBC"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="93.846"
                     /coverage="100.0"
                     /evalue="1.61e-116"
     Typing          14935..15662
                     /name="MOBC"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="93.416"
                     /coverage="100.0"
                     /evalue="1.38e-140"
ORIGIN
        1 tgattatcat ccagtaccta aaacagaaga cataaaggga cttggggagt taaagcgagg
       61 tgatcctaaa acctaaacaa ggtggtggtg gtaaagccag gccgatggta tggcgataaa
      121 agaacggaaa ttgaatggga ttcccagcac ggtgagcaga aggagtatcg tgcccagtga
      181 tatctgaaca cctgaagcgc gactgatccc caaggcaggt aagcaggtta aaggagccag
      241 atcaaaacgg aacattaaaa atatcttttg agagagaagt aaatatgggg cttaaattac
      301 gttttgtgta gtttgataga aaagctagaa gagttttaaa gaggaaggaa agtattctaa
      361 agactttgag cgatagtttc tgtcattgaa agcttaggaa tgcaacacaa aggatatatt
      421 aataatggtg agtttgattt gaaagaaaga atgggttctt ctacagccat tttaaaatca
      481 aataaaacct gatgtggata attgttatat agcttttgat tatcaggaca gtaactggta
      541 acaaaaatta tcaggatgat ttgaaatact gacttccggt gttcaggatg aatgccgggt
      601 caatctgaga aagtatgaaa aggtaaagac tatttttctt ttgtattgat tgttgctgct
      661 cttctggccg catgtcaggc caagagtata tccgggatgt tccagaaggg gcggaacggt
      721 ggcaccatcg tctcctctga actggaggat catgattcag tagaaagatc aaggatcttc
      781 ttgagatcct tttttctgca tggcgtcttt tgccctgtaa gcgaaaaaac cgcaaaggtg
      841 gtttgatcaa gggtaatcag ttgggaactg cttaaccgta gtaacttctt tcgaggcaca
      901 gcaaccaaat ccctgtccag tggccggact ttggcgcaca cttcaaaaca accgcgtgtt
      961 tagctaaaca aatcctctgc gaactcccag ttaccaatgg ctgctgccgg tggcgtttgc
     1021 gtctttttcc gggttggact cagtgaacag ttaccggata aggcgcagca gtcgggctga
     1081 acagggagtt cttgcttcag gccagcttgg agcgaacggc ctacaccgag ccgagatacc
     1141 ggtgtgtgag ctatgaagcg ccacacttcc cgcaaaggga acggcggaca ggtatcccgg
     1201 taaacggcag aggtcggaac aggagagcgc aagaggagcg acctaccgga agcggtgggg
     1261 atctttaaag tcctgtcggg tttcgcccgt actgtcagat tcatggttga gcctcacggc
     1321 tcccacagat gcactgaaaa agcgtctgtt tgtgaactct ggcgggaggg cgggctatcg
     1381 gaaacgcgcc accggcgcgg ccctgccgtt ttgcctcaca tgttggtccc ctgctttatc
     1441 cacacggaat ctgtgggtaa ctttgtatgt aatcagcgcc cgcccgcagt ctcacgcccg
     1501 ggcgtggcga cggagtgagc gaggaggcgc aatttccccc ggcacctgca agacggtcac
     1561 ccggacgctg atgtaggata ttgtcccctg attaagtctt tctattcctg acgatcaatt
     1621 atcaggatag gtgaaccatg tcagtttcgc tgaacatttt gcgttaacta tctctgttgc
     1681 ttttctcctt gcggagaaat gcaagtcatc cccgctgggg cgtggctgac ttcaggggaa
     1741 aagaccttgc ttacgctggc tggacgccac cgacgcacgg tcttttcccc tctttctggc
     1801 tctgtccggc tggacgccag cccgcccaaa gtcacccggc cccgtcaggc tcacgcctga
     1861 ccaccctaaa aatccacggt gctggacgca cctgacgaag cagcaaagct gctcctgatt
     1921 ttgcgggtgg tcagccgctc atatggcgaa ctctgacggg gcggaacacc ggaaaagacc
     1981 gcactggggt gccgcctttt cctctcacac gctggggcgt gctcgttgtt cctccggggc
     2041 tgcgcctttc cgcatggggc ggaaagaggc tggcctccgc ggtgaaagct gaacgcaatc
     2101 accacggacg tgaccgccgc cgccatgcct tggggcatgt ccgcggcttg tgcagcgggg
     2161 gctgcgcatc acgccggtaa acccgtcgtc tgaaggagag agattgcatg tttaatacgg
     2221 attcgcttgc ctggcagtgg catatcccgg agctggcccg gcagatttac ccgtgggtca
     2281 gctggctgta ccggagtatt acagtctggc cggtttttct ggttatcggc ctgtttttcg
     2341 gtctggctga actctgggcc ggccgaatgc gttttgtggg gctgagccat aaggcgcggc
     2401 ggagtatgcc gatcgctata agcgcgataa taaccggact gtgccatttt cggtgctggc
     2461 ctcgctggat tcacccgggc ggatggtcag ggcacggcga catgtctgga actacgcgta
     2521 ctggctgacc ggcgctgccg gtctggccct tctggggggg ctggttgtcg ccgtgtttat
     2581 cgagagctgg ggagaaaccg tcctgcgccc ggacctctat gcgaacgcag attattacct
     2641 gctgcagccg gctaacctgt tcgggatagc ctggtgtgcc ggagggcttg tcgccggcgt
     2701 ccttctggcg cggctgctgg cgttcctgct gcttgatggt cattttgcgg ccgctgacga
     2761 ggcggtgaac gcgaaactga atcaggagag ccggcgcagc agccagcgga ccggagaaat
     2821 gacagacgtc cgccacctgc atttcgggga gccggtaccg gttaacgcgc tggccgattt
     2881 ttccacggag caggcccgga aacagcaggc ggtgtttctg ggtaaggatg agcagggcca
     2941 gccggtgctg gtccctcgtg atacctggcg caagaccaat attcagatcc tcggcctgcc
     3001 cgggagcggc aagagcgcga tggccaccaa cgcgctcatt cgctgcgtac gcgatttcgg
     3061 ggacgctgtg gtgtacttcg accccaaagg ggacgcgtgg gcgccgcacg tcttccgggc
     3121 gcactgcccg gacttcaccc tgctggatct gcggccgggg aaaccggcgc agctgaatct
     3181 gttccgcgat ctcgaccagt acgccctgaa gaatctgctg gttgccgggt ttaacctgag
     3241 tgagaccggc gacgtggcgg accactaccg catcagcgag cagaaagcgg cgaagctgat
     3301 tgcggagcag ttcccgcagg gggcaaacat tcagcaggtg ctggcggcgg cgtacgcgtt
     3361 gccggaggcc ctgaaaaagg acgtgaaggg gctgatcacc aagctggaga acgtggccga
     3421 cctgagcgtc ctgcagacgg acagcggtat cgatgtggcg gggataatca acggcggcgg
     3481 ctgcctgtac gtcatcggct cgatggacga tgaggcggtg atccgggtgc agaagatgct
     3541 gtttgcccgc tgcgcgcaaa tcatcattgc gcgggatgag ttccggaggt ggccgcacgc
     3601 gagcatcatg ctcgatgaga ttaaatatct gctgtcgaag tacgtgctga acgcgctggg
     3661 gacgctgcgc agccgggact gcaacctgct gctcgcgcac cagtcgctgg gcgacttcgg
     3721 tcagtgcggg caggatctgc ccgctgattt tgtgaaaacc acggtactgg ataacacgcc
     3781 gatccgctgg ttctatcgcg cggccagcca ggagtccgcg cagtgggcgg cgggccagac
     3841 cggggagatc cgggtggacg tggagcgccg ccgggccagc cgggaggcgg ggaacgtgga
     3901 gcacatcagc ggcgacagct tcatccagaa ggaggcgcgg ccgctgtttg acgtgaacac
     3961 cctgcaacac ctgcctgacg ggttcgcggt gatgaccggg ctgggcgtgg cgcggctggc
     4021 gttcagcagc ccgctgcggg ttgagcgccg ggaaatttcg ctgaaaacct tcccggtgct
     4081 ggcgaaaacg gacccgctgg cggagtacct gcctccggcc gacggcggcg gaccaaagcg
     4141 gatgatgatt ttgcggggct ttactgatga cactggagca gtacaacgtc agccacgcga
     4201 agcggcaggc gcggaacgcg gagaaaacac ggctgaccct gcgctggctg cgggaagagc
     4261 tgtgttccac ggcggagctg gttgcgcgac ggctggggat tgcggcggta cagccggttt
     4321 accgcttcct ggacagtctg gtggcgaaag ggctgctggt ccgggcgaaa tacccggttg
     4381 acggccgtca ggtcagcgtg tgggggctga cgccgcacgg ggtggcgttc tcgttcgacg
     4441 aggacgagcc gctgacggac gttattccgt ttcagccgtc aagggtgtcg gcggcgcagc
     4501 tgccgcaccg gctggccgtg cagtccctgc gcctctccat ggagggccgg ggggccaccg
     4561 gctggcggta cctgcaccgt atggccctga aagggatgaa agtgccggac gcgctggcgg
     4621 agctggacgg cagaacggtg gcatttgagg tagagcgcac cgtcaagagc cgcaggcggt
     4681 atcaggaagt ggtgtccggg tatctgttca accgccgggc gaacggcatc gatgaaatct
     4741 ggtacatctg cctgaccggc cgacgcttgt ccgggtacag cgggcgattc tggcggtgga
     4801 tgaaatcgtg aatccacaga ccggcgaggc ccgcaaaacg gtggagctgg accgggagag
     4861 gctgttcgcg tgctttaaat ttatgacaac ggagtgaggg attatggcgc tgtacatggt
     4921 atttattgag gacgtggaag acaaagacgg cgagcgctgc attatgccaa ccagcgagca
     4981 tctggaagac atggtggtgc tcgcctggca gaccggggcg tatgttttct gttttgtcga
     5041 ccgggcccag catctggcga tgatgaaatc catcgggatg tatgacgagc ggctcaacag
     5101 cgacgaaaaa gccacgtact ttttcaccgg tgaaaatccg caatgggaac gggacaaacc
     5161 cacaggaatg aagctgtgtg attacctcta tcgaaaggtg gagcggttcg ccatcgagaa
     5221 cggtgtgcag gtggttgatg ccgggaagtg ctcaccggag cagattaacg cgatgattga
     5281 ggtggtcagc gagcggcacg gggaaagcgc ggtgaacgag aagctgaaag cggagctgat
     5341 gcgggaatat aacagccgct attttaacgt gccggtgcct gaactgccgg aggacaaacc
     5401 cgcccgccgg tggtggccgt tcggcaaaaa ataacgccag caccggcatg gccggtgctg
     5461 ttattcttcc ccgagcttat cccgcatcac ctgccagagt gtttccgcat cctcgtgaag
     5521 ccgttcgcac atgtcggccg gggtatccat gtccagctcg ttcagctttt ccagcaacag
     5581 cagcgactga tccttaatga atttagccat attgagggca gttttttcct gcttcgtcat
     5641 gttctccatt cccttcggta agttctcagc taaaccagcc ggaccagaag cgttttttct
     5701 tctgtgtcag ttctgttgtc aatctgtcca cttcggcctg gagtttccgg cgctcatcat
     5761 cgtgctggcg gcgttcttct tcccgggatg ttttatcttc cagcatcagg gtgacagcct
     5821 gccggagatc ggccagttcc ttttgcattg ccagaagctg ttcctgtggg aaattttttt
     5881 gtgtattttc acggtgtgaa atgccgggaa tttgtttctc agggatattc acatttccgt
     5941 atacacggat cagttctgac acatccacga cagggttgtt tttcccgtca cgtgacacgg
     6001 taacctttcc ctgttttaca tgattgtata gcgttcttct ggtaatgccc gcggcttgtg
     6061 ctgcctgtga aaggttgagc aatgttttcg ccactgtata cccctgattt tatcgggtgt
     6121 gaaaggtgtg taatttctca cggtaaatgt atcgctgaat tttacccgtt tttccgttca
     6181 ggatgtggtt ttctgacgcg ctgcgcttgt caaaccggcg acggccacgc aatgaattgc
     6241 gcccccgtca tcggttatta gaggctgtct gcccccggat acccggattc tttctgatgc
     6301 ctgacggtga cgatcacaat ctggtccatt tcccggtcgt ggcggtagag catcacatag
     6361 ccactgtcgc caaacccgat caccagttcc ttatattcca gcggcagaaa cggcaccggg
     6421 cggccaatgt ctggcaatgt tttcagttgc tggatagccc ggacgatcac ctcacctcct
     6481 tttctggctg ccagccgatt tttggttttg agaaagtcct gaaggcgttg taaatcgcgc
     6541 tgtgccagcg cggaaatcgt tacctgtggc atggcggagc atcctgctcg ttctcagttc
     6601 ccccaggtac ttatccaggc ttccgcttct tccgcagtaa ggtgcagacc cgtttcctga
     6661 tagtgctgcc atgcggcctg tccgtcccgc aggtactggc tgcgcttctc ttcccggtcg
     6721 atgtattcgg tgattgcctc cagcattagc gcgtgcgctg agcggtgccg gtcatcggcc
     6781 agcgttttca gccggtcctt aagttcttca tcgagcctga tggatgttgc tgatgacata
     6841 aaaagcccct ttgtagtcat atgtattaca catgactact ttaatccgtg gcggcgctat
     6901 ttgccagaaa tacggctttt gctgcccatt tttcagcttc gcttccacta atcagggctg
     6961 ctacaggctc actcatcatc caggactatt gcagcctgcg ggttaaagga cctgttactg
     7021 gcggcaacca tcatcattga gcttttgggt ggtgactggt cgcggatcct gtaagccgtc
     7081 atttttcaga ctgaattcaa aatttataac ctgtcgcatt gccgggtgcc ctgcgggata
     7141 tagccagtgc ctcattgccg tcagcgtttc ccgaaaaaaa aggtgacagc cggtaagcga
     7201 cacgttgtcc actcgtccat cgtccagaat atcaaacgtg gcggtcacct gaccttcgat
     7261 gcgttttgct gcggcctgta ccgggtaggt tggctgcagt gtggttacgg gttttagtgg
     7321 tatcgcatgt accggagtga ggaacatggc cgccagcact gtcagagtaa aagctttcat
     7381 ggtctgaaat ccagaggggc gtttttgaat atttgccagg tattttcatc cggtgccggc
     7441 ggaattttgg cgtgggtaac ggctgatatt gctgctttac agagtttcgg atctcctcct
     7501 tcagcaatgg cgctgttcag agtgccatca cgttgtatgg atatccgcac ggtgcacatt
     7561 tttcccgcat aggcctctgg ttcaaacatc tgcatttcaa cagcggtctt gatggccgca
     7621 gcgtagctac tgattttaga tgacttatcc agagtataaa ttttcggcgg ctgggtggtg
     7681 gaatgcttac aggccgtcag gagtaagggg ctgcacaatg ccagcaggat aaagggtatt
     7741 aaacgcatcg ggttgatgac ctgtcagtaa aaaatgttac atgtatattt gtcactcttt
     7801 acggccacgt tcatttacat aaacacggct tatcgtatcg tttttacacc aaacggcccg
     7861 ccatgcagtt gcgtgcatag gcatgcagcg ggttacaatt taccgggcgc gtttccggcg
     7921 gttttccggg tggtttgttg cctgttttat cccgtagccg ccggaaacgc cctcagaccg
     7981 tctgagcggt gcgggcaatg cgacgttatg gtaaataccg agaccggtta gagatcaagg
     8041 ggtgaaagtc cccgaccatt gaaggaccag caatccacaa ggtccccgag tcatgcgttg
     8101 cataccgcga ggtatggggc gaagcgttga caggggtgtt gacaggccag ccattgagcc
     8161 acgaaatgta tattaaatta ccgggtgccg acgttgtact gttaacggaa ggcaacatca
     8221 tagggtgcga tactgcgagt gccacatgga cccggcgggg tctgagaccc tggcatgtca
     8281 atacgatctc tacgcgggaa ccgggagatc tcccctctga ccatctgcca gtgtcggaga
     8341 tggcccgcac cgggaagacg aggagtcata gccggtgatg tacggagagg agaagtcgga
     8401 ctcgctcata gtagcggcga agcaggcgaa caacccgaaa ggagcggagt cagtggagcg
     8461 aaggagcggg gccaagggga acgcggaaca gccacacatg cgccggacac agagccggga
     8521 aagcatgtca cagaggctgt cacgcgtgcg ggaagctgcg aagcagcgga agaaagaacg
     8581 gtttacagca ttgttccacc tgctgacagt cgaagcactg gaagccgcat tcctctcctg
     8641 agcaggaaag cggccgccgg agtggatggc atcaggtgga tggactacgc cggaaacatg
     8701 aagaacaaca taacagatct gcaccggagg ctacatcagg gcagctacag ggcgcagccc
     8761 ggcaggcgtc actacatccc aaaagcggat ggaaaacaac gcccgctcgg catcgcctcg
     8821 ctggaggaca agatcgtcca gtatgcgctg gtgaaaatcc tgaacgcagt ctatgaaaac
     8881 gactttatgg ggttctcata cgggttcaga ccgggcgaag ccagcacgat gcactggacg
     8941 cactggccac agggctggta cgcactaacg taaactgggt actggatgcc gacatcagtc
     9001 agttcttcga cagggtgagc cacgaatggc tgatcaggtt cacagagcat cggatcggcg
     9061 accggagggt aatcaggctc atacgtaagt ggctcacagc cgggacgtcg gagagggtca
     9121 atggcgagca acggaggaag gcaccccaca gggtgcggtc atctcaccgc tgctggcaaa
     9181 catatacctc cactacgtct tcgatctgtg ggcgcatcag tggcgacgtc gctatgccac
     9241 aggcaatgtg gtaatggtca gatacgccga tgacatcgtc atcgggttcg acaaacgata
     9301 cgatgcccgg cgcttccgta tagccatgca gcgcagactg agggagttcg gactcacggt
     9361 tcacccggag aaaacccgtc tgatggagtt cggccgcttc gctgccgaaa accgtgccat
     9421 caggggaaaa ggcaaaccag aaacgttcaa cttcctcggg ttcacgcaca tcagcgggaa
     9481 agatcgcaac ggcaggttca tgctgatacg aaagacccgc cgggatcgga tgacggcaac
     9541 tctgaaagcc atcaaagacg gtctgcgaag gcgctggcat tactcaatcc ccgaacaggg
     9601 aaaatggctc aggaggagag tggttcaggg atacctgaac tatcactcgg taccgggcaa
     9661 cttccccacc atgcagaagt tcaggacaca cgtaacaaac ctctggcgcc gggcgctcag
     9721 gcgcaggagc cagaaggatg atacgacctg gacgaaagca aacaaactgg cagccgcatg
     9781 gctaccaagg gttcgggttc ttcatccatg gcctgtggag cggttcaccg ccagacaccc
     9841 gaggcaggag cccggtgcgt aaatcgcgca cgccgggatc tgtgcggggg gtatccggta
     9901 acgggtatcc tattgcggtt gtcgcaggtc ggccaatgag tgtccctgtg gtggatgcga
     9961 aaccgacaaa acgtccgggg gtattcagtg tgtcgattcc gggtctcccg tctctgcagg
    10021 tgagcgtacc gaaaggtgtt ccgacagcga aagccccgcc aaaaggcatt gttgctgaaa
    10081 aaggtgattc acgtccggct ggttttacag ccggtggtaa ctcccgtgag gccgttattc
    10141 gtttcccgaa agagaccgga cagaagccgg tttatgtgtc ggtgacagat gttcttaccc
    10201 cggcacaggt aaaacagcgt caggaggaag aaaagcgtcg ccagcaggca tgggacgccg
    10261 ctcatccgga agaggggctg aaaagagact atgataaagc gaaagctgag ctggatgccg
    10321 aagataaaaa tattgcgacc ttaaacagcc gcattgcatc gacagagaag gcgctccccg
    10381 gtgcaagggc tgctgttcag gaagccgata aaaaggtaaa agaggcagag gcaaataaag
    10441 atgattttgt gacttataac ccgcctcatg aatatggctc cgggtggcag gatcaggttc
    10501 gctatcttga taaggatatt cagaatcaga atgagaaatt aaaagcggct caggcatctt
    10561 taaacgcaat gaatgaatcc ttatccagag ataaggctgc acttaccggg gcgatggaga
    10621 gccggaaaca aaaggagaaa aaagcgaagg atgcagaaaa taagttaaat gaggaaaaga
    10681 acaagcctcg caaggggact aaagactacg gccatgatta tcatccagta cctaaaacag
    10741 aagacataaa gggacttgga gagttaaagc gaggtgatcc taaaacacct aaacaaggtg
    10801 gtggtggtaa gcgggcccga tggtatggcg ataaaaaacg taaaatttat gaatgggatt
    10861 cccagcacgg tgagcttgaa gggtatcgtg ccagtgatgg cgaacaccta ggcgcatttg
    10921 atcccaaaac gggtaagcag gttaaagggc cagatccaaa acggaacatt aaaaaatatc
    10981 tttgagaggt aaatatgggg cttaaattac gtttgacatg gtttgataag aaaactgaag
    11041 agtttaaagg ggaagagtat tctaaagact ttggtgacga tggttctgtc attgaaagct
    11101 tgggaatgcc tttaaaggat aatattaata atggtgagtt tgatttgaag aaagaatggg
    11161 ttcctttact acagccattt tttaaaaatc aaataaaacc tgatgtggat aattgttata
    11221 tagcttttga ttatcgggac ggtaactggt aacaaaaaat tatcaaggat gatttgaaat
    11281 actgacttcc ggtgttcagg gatgaatgcc ggagtcttta aatacaggga aagtatatga
    11341 aaaaggtaaa gactattttt ctttttatat tgattgttgc tggctttctt ctggccgcat
    11401 gtcaggcaaa ttatatccgg gatgttcagg gcggaacggt ggcaccatcg tcctcctctg
    11461 aactgacggg gatcgcggtt cagtagaaaa gatcaaagga tcttcttgag atcctttttt
    11521 tctgcgcgta atcttttgcc ctgtaaacga aaaaaccacc tggggaggtg gtttgatcga
    11581 aggttaagtc agttggggaa ctgcttaacc gtggtaactg gctttcgcag agcacagcaa
    11641 ccaaatctgt ccttccagtg tagccggact ttggcgcaca cttcaagagc aaccgcgtgt
    11701 ttagctaaac aaatcctctg cgaactccca gttaccaatg gctgctgcca gtggcgtttt
    11761 gcgtgctttc ccgggttgga ctcaagtgaa cagttaccgg ataaggcgca gcagtcgggc
    11821 tgaacgggga gttcttgctt acagcccagc ttggagcgaa cgacctacac cgagccgaga
    11881 taccagtgtg tgagctatga gaaagcgcca cacttcccgc aagggagaac ggcggacagg
    11941 tatccggtaa acggcagggt cggaacagga gagcgcaaga gggagcgacc taccggaaac
    12001 ggtggggatc tttaagtcct gtcgggtttc gcccgtactg tcagattcat ggttgagcct
    12061 cacggctccc acagatgcac cgaaaaagcg tctgtttatg tgaactctgg caggagggcg
    12121 gagcctatgg aaaaacgcca ccggcgcggc cctgccgttt tgcctcacat gttagtcccc
    12181 tgcttatcca cggaatctgt gggtaacttt gtatgtgtcc gcagcgcccg ccgcagtctc
    12241 acgcccggag cgtagcgacc gagtgagcga ggaggcgcaa tttccccggc acctgcaaga
    12301 cggtcaccgg acgcgctgat gtgggatatt gtcccctgat taagtctttc tattccctga
    12361 cgatcaatta tcaggatagg tgaaccatgt cggtttttcg ctgaacattt tacgttaacc
    12421 tatctctgtt gcttttttct ccttgcggag aaatgcaagt catccccgct ggggcgtggc
    12481 tgacttcagg ggaaaagacc ttgcttacgc tggctggacg ccaccgacgc acggtctttt
    12541 cccctctttc tggctctgtc cggctggacg ccggccacgc cagaaattca cccggccccc
    12601 gtcaggctca cgcctgacca cccacaaaaa tccacggtgc tggacgcacc tgacgaagca
    12661 gcaaagctgc tcctgatttt gcgggtggtc agccgctcgc tatggcgaac tctgacgggg
    12721 gccggaacac cggaaaagac cgcactgggg tgccgccttt tcctctcaca cgctggggcg
    12781 tgctcgttgt tcctccgggg ctgcgccttt tccgcatggg gcggaaagag gctggcctcc
    12841 gcggtgaaag ctgaacgcaa tcaccacgga cgtgaccgcc gccgccatgc cttggggcat
    12901 gtccgcggct tgtgcagcgg gggctgcgca tcacgccggt aaacccgtcg tctgaaggag
    12961 agagattgca tgtttaatac ggattcgctt gcctggcagt ggcatatccc ggagctggcc
    13021 cggcagattt acccgtgggt cagctggctg taccgggagt attacagtct ggccggtttt
    13081 tttctggtta tcggcctgtt tttcggtctg gctgaactct gggccggccg aatgcgtttt
    13141 gtggggctga gccataaggc gcggcgggag tatgccgatc gctataagcg cgataataac
    13201 cggactgtgc cattttcggt gctggcctcg ctggattcac ccgggcggat ggtcagggca
    13261 cggcgacatg tctggaacta cgcgtactgg ctgaccggcg ctgccggtct ggcccttctg
    13321 ggggggctgg ttgtcgccgt gtttatcgag agctggggag aaaccgtcct gcgcccggac
    13381 ctctatgcga acgcagatta ttacctgctg cagccggcta acctgttcgg gatagcctgg
    13441 tgtgccggag ggcttgtcgc cggcgtcctt ctggcgcggc tgctggcgtt cctgctgctt
    13501 gatggtcatt ttgcggccgc tgacgaggcg gtgaacgcga aactgaatca ggagagccgg
    13561 cgcagcagcc agcggaccgg agaaatgaca gacgtccgcc acctgcattt cggggagccg
    13621 gtaccggtta acgcgctggc cgatttttcc acggagcagg cccggaaaca gcaggcggtg
    13681 tttctgggta aggatgagca gggccagccg gtgctggtcc ctcgtgatac ctggcgcaag
    13741 accaatattc agatcctcgg cctgcccggg agcggcaaga gcgcgatggc caccaacgcg
    13801 ctcattcgct gcgtacgcga tttcggggac gctgtggtgt acttcgaccc caaaggggac
    13861 gcgtgggcgc cgcacgtctt ccgggcgcac tgcccggact tcaccctgct ggatctgcgg
    13921 ccggggaaac cggcgcagct gaatctgttc cgcgatctcg accagtacgc cctgaagaat
    13981 ctgctggttg ccgggtttaa cctgagtgag accggcgacg tggcggacca ctaccgcatc
    14041 agcgagcaga aagcggcgaa gctgattgcg gagcagttcc cgcagggggc aaacattcag
    14101 caggtgctgg cggcggcgta cgcgttgccg gaggccctga aaaaggacgt gaaggggctg
    14161 atcaccaagc tggagaacgt ggccgacctg agcgtcctgc agacggacag cggtatcgat
    14221 gtggcgggga taatcaacgg cggcggctgc ctgtacgtca tcggctcgat ggacgatgag
    14281 gcggtgatcc gggtgcagaa gatgctgttt gcccgctgcg cgcaaatcat cattgcgcgg
    14341 gatgagttcc ggaggtggcc gcacgcgagc atcatgctcg atgagattaa atatctgctg
    14401 tcgaagtacg tgctgaacgc gctggggacg ctgcgcagcc gggactgcaa cctgctgctc
    14461 gcgcaccagt cgctgggcga cttcggtcag tgcgggcagg atctgcccgc tgattttgtg
    14521 aaaaccacgg tactggataa cacgccgatc cgctggttct atcgcgcggc cagccaggag
    14581 tccgcgcagt gggcggcggg ccagaccggg gagatccggg tggacgtgga gcgccgccgg
    14641 gccagccggg aggcggggaa cgtggagcac atcagcggcg acagcttcat ccagaaggag
    14701 gcgcggccgc tgtttgacgt gaacaccctg caacacctgc ctgacgggtt cgcggtgatg
    14761 accgggctgg gcgtggcgcg gctggcgttc agcagcccgc tgcgggttga gcgccgggaa
    14821 atttcgctga aaaccttccc ggtgctggcg aaaacggacc cgctggcgga gtacctgcct
    14881 ccggccgacg gcggcggacc aaaagcggat gatgattttg cggggcttta ctgatgacac
    14941 tggagcagta caacgtcagc cacgcgaagc ggcaggcgcg gaacgcggag aaaacacggc
    15001 tgaccctgcg ctggctgcgg gaagagctgt gttccacggc ggagctggtt gcgcgacggc
    15061 tggggattgc ggcggtacag ccggtttacc gcttcctgga cagtctggtg gcgaaagggc
    15121 tgctggtccg ggcgaaatac ccggttgacg gccgtcaggt cagcgtgtgg gggctgacgc
    15181 cgcacggggt ggcgttctcg ttcgacgagg acgagccgct gacggacgtt attccgtttc
    15241 agccgtcaag ggtgtcggcg gcgcagctgc cgcaccggct ggccgtgcag tccctgcgcc
    15301 tctccatgga gggccggggg gccaccggct ggcggtacct gcaccgtatg gccctgaaag
    15361 ggatgaaagt gccggacgcg ctggcggagc tggacggcag aacggtggca tttgaggtag
    15421 agcgcaccgt caagagccgc aggcggtatc aggaagtggt gtccgggtat ctgttcaacc
    15481 gccgggcgaa cggcatcgat gaaatctggt acatctgccc tgaccggccg acgcttgtcc
    15541 gggtacagcg ggcgattctg gcggtggatg aaatcgtgaa tccacagacc ggcgaggccc
    15601 gcaaaacggt ggagctggac cgggagaggc tgttcgcgtg ctttaaattt atgacaacgg
    15661 agtgagggat tatggcgctg tacatggtat ttattgagga cgtggaagac aaagacggcg
    15721 agcgctgcat tatgccaacc agcgagcatc tggaagacat ggtggtgctc gcctggcaga
    15781 ccggggcgta tgttttctgt tttgtcgacc gggcccagca tctggcgatg atgaaatcca
    15841 tcgggatgta tgacgagcgg ctcaacagcg acgaaaaagc cacgtacttt ttcaccggtg
    15901 aaaatccgca atgggaacgg gacaaaccca caggaatgaa gctgtgtgat tacctctatc
    15961 gaaaggtgga gcggttcgcc atcgagaacg gtgtgcaggt ggttgatgcc gggaagtgct
    16021 caccggagca gattaacgcg atgattgagg tggtcagcga gcggcacggg gaaagcgcgg
    16081 tgaacgagaa gctgaaagcg gagctgatgc gggaatataa cagccgctat tttaacgtgc
    16141 cggtgcctga actgccggag gacaaacccg cccgccggtg gtggccgttc ggcaaaaaat
    16201 aacgccagca ccggcatggc cggtgctgtt attcttcccc gagcttatcc cgcatcacct
    16261 gccagagtgt ttccgcatcc tcgtgaagcc gttcgcacat gtcggccggg gtatccatgt
    16321 ccagctcgtt cagcttttcc agcaacagca gcgactgatc cttaatgaat ttagccatat
    16381 tgagggcagt tttttcctgc ttcgtcatgt tctccattcc cttcggtaag ttctcagcta
    16441 aaccagccgg accagaagcg ttttttcttc tgtgtcagtt ctgttgtcaa tctgtccact
    16501 tcggcctgga gtttccggcg ctcatcatcg tgctggcggc gttcttcttc ccgggatgtt
    16561 ttatcttcca gcatcagggt gacagcctgc cggagatcgg ccagttcctt ttgcattgcc
    16621 agaagctgtt cctgtgggaa atttttttgt gtattttcac ggtgtgaaat gccgggaatt
    16681 tgtttctcag ggatattcac atttccgtat acacggatca gttctgacac atccacgaca
    16741 gggttgtttt tcccgtcacg tgacacggta acctttccct gttttacatg attgtatagc
    16801 gttcttctgg taatgcccgc ggcttgtgct gcctgtgaaa ggttgagcaa tgttttcgcc
    16861 actgtatacc cctgatttta tcgggtgtga aaggtgtgta atttctcacg gtaaatgtat
    16921 cgctgaattt tacccgtttt tccgttcagg atgtggtttt ctgacgcgct gcgcttgtca
    16981 aaccggcgac ggccacgcaa tgaattgcgc ccccgtcatc ggttattaga ggctgtctgc
    17041 ccccggatac ccggattctt tctgatgcct gacggtgacg atcacaatct ggtccatttc
    17101 ccggtcgtgg cggtagagca tcacatagcc actgtcgcca aacccgatca ccagttcctt
    17161 atattccagc ggcagaaacg gcaccgggcg gccaatgtct ggcaatgttt tcagttgctg
    17221 gatagcccgg acgatcacct cacctccttt tctggctgcc agccgatttt tggttttgag
    17281 aaagtcctga aggcgttgta aatcgcgctg tgccagcgcg gaaatcgtta cctgtggcat
    17341 ggcggagcat cctgctcgtt ctcagttccc caggtactta tccaggcttc cgcttcttcc
    17401 gcagtaaggt gcagacccgt ttcctgatag tgctgccatg cggcctgtcc gtcccgcagg
    17461 tactggctgc gcttctcttc ccggtcgatg tattcggtga ttgcctccag cattagcgcg
    17521 tgcgctgagc ggtgccggtc atcggccagc gttttcagcc ggtccttaag ttcttcatcg
    17581 agcctgatgg atgttgctga tgacataaaa gcccctttgt agtcatatgt attacacatg
    17641 actactttaa tccgtggcgg cgctatttgc cagaaatacg gcttttgctg cccatttttc
    17701 agcttcgctt ccactaatca gggctgctac aggctcactc atcatccagg actattgcag
    17761 cctgcgggtt aaaggacctg ttactggcgg caaccatcat cattgagctt ttgggtggtg
    17821 actggtcgcg gatcctgtaa gccgtcattt ttcagactga attcaaaatt tataacctgt
    17881 cgcattgccg ggtgccctgc gggatatagc cagtgcctca ttgccgtcag cgtttcccga
    17941 aaaaaaaggt gacagccggt aagcgacacg ttgtccactc gtccatcgtc cagaatatca
    18001 aacgtggcgg tcacctgacc ttcgatgcgt tttgctgcgg cctgtaccgg gtaggttggc
    18061 tgcagtgtgg ttacgggttt tagtggtatc gcatgtaccg gagtgaggaa catggccgcc
    18121 agcactgtca gagtaaaagc tttcatggtc tgaaatccag aggggcgttt ttgaatattt
    18181 gccaggtatt ttcatccggt gccggcggaa ttttggcgtg ggtaacggct gatattgctg
    18241 ctttacagag tttcggatct cctccttcag caatggcgct gttcagagtg ccatcacgtt
    18301 gtatggatat ccgcacggtg cacatttttc ccgcataggc ctctggttca aacatctgca
    18361 tttcaacagc ggtcttgatg gccgcagcgt agctactgat tttagatgac ttatccagag
    18421 tataaatttt cggcggctgg gtggtggaat gcttacaggc cgtcaggagt aaggggctgc
    18481 acaatgccag caggataaag ggtattaaac gcatcgggtt gatgacctgt cagtaaaaaa
    18541 tgttacatgt atatttgtca ctctttacgg ccacgttcat ttacataaac acggcttatc
    18601 gtatcgtttt tacaccaaac ggcccgccat gcagttgcgt gcataggcat gcagcgggtt
    18661 acaatttacc gggcgcgttt ccggcggttt tccgggtggt ttgttgcctg ttttatcccg
    18721 tagccgccgg aaacgccctc agaccgtctg agcggtgcgg gcaatgcgac gttatggtaa
    18781 atacccctta ccggcggcgc tgtggctgcc aggtgaaggt ggtttccgta gcctcgtatt
    18841 tctcccgacg catttcctgc gcccgcctgg cttcacgttc gtcctgaatg gcacgaagca
    18901 ccctttcccg cacctgttgt tttaccgcct ttggcagcgt tttgttccct ttcaggccca
    18961 tggccagtgc ctgagcgaca aaggcgtccg ccaggcgctt ttcttcagcg ggagtcagtt
    19021 tcaggtgcgt catagtggcc tccgggcgtc tcaggtttcc cgaacagttt aaccgcaggt
    19081 cctctcctca tgccagttag ctttcagatg tgtctatacc atctgaaatg taagtgtgat
    19141 gaatgtctta aataataaaa tttgttgcca tgagaaattt tcgggaaaag acgcgatctg
    19201 cttacaggtg gctccgggcg cttttttgtg cctgaagatg agaactaatc tcatatattg
    19261 acacctgaaa acgggaggag taaggtaata attatactgt gtatatgtac agtgtgcgcc
    19321 gggagaccgg ttagagatca aggggtgaaa gtccccgacc attgaaggac cagcaatcca
    19381 caaggtcccc gagtcatgcg ttgcataccg cgaggtatgg ggcgaagcgt tgacaggggt
    19441 gttgacaggc cagccattga gccacgaaat gtatattaaa ttaccgggtg ccgacgttgt
    19501 actgttaacg gaaggcaaca tcatagggtg cgatactgcg agtgccacat ggacccggcg
    19561 gggtctgaga ccctggcatg tcaatacgat ctctacgcgg gaaccgggag atctcccctc
    19621 tgaccatctg ccagtgtcgg agatggcccg caccgggaag acgaggagtc atagccggtg
    19681 atgtacggag aggagaagtc ggactcgctc atagtagcgg cgaagcaggc gaacaacccg
    19741 aaaggagcgg agtcagtgga gcgaaggagc ggggccaagg ggaacgcgga acagccacac
    19801 atgcgccgga cacagagccg ggaaagcatg tcacagaggc tgtcacgcgt gcgggaagct
    19861 gcgaagcagc ggaagaaaga acggtttaca gcattgttcc acctgctgac agtcgaagca
    19921 ctggaagccg cattcctctc ctgagcagga aagcggccgc cggagtggat ggcatcaggt
    19981 ggatggacta cgccggaaac atgaagaaca acataacaga tctgcaccgg aggctacatc
    20041 agggcagcta cagggcgcag cccggcaggc gtcactacat cccaaaagcg gatggaaaac
    20101 aacgcccgct cggcatcgcc tcgctggagg acaagatcgt ccagtatgcg ctggtgaaaa
    20161 tcctgaacgc agtctatgaa aacgacttta tggggttctc atacgggttc agacccgggc
    20221 gaagccagca cgatgcactg gacgcactgg ccacagggct ggtacgcact aacgtaaact
    20281 gggtactgga tgccgacatc agtcagttct tcgacagggt gagccacgaa tggctgatca
    20341 ggttcacaga gcatcggatc ggcgaccgga gggtaatcag gctcatacgt aagtggctca
    20401 cagccgggac gtcggaggag ggtcaatggc gagcaacgga ggaaggcacc ccacagggtg
    20461 cggtcatctc accgctgctg gcaaacatat acctccacta cgtcttcgat ctgtgggcgc
    20521 atcagtggcg acgtcgctat gccacaggca atgtggtaat ggtcagatac gccgatgaca
    20581 tcgtcatcgg gttcgacaaa cgatacgatg cccggcgctt ccgtatagcc atgcagcgca
    20641 gactgaggga gttcggactc acggttcacc cggagaaaac ccgtctgatg gagttcggcc
    20701 gcttcgctgc cgaaaaccgt gccatcaggg gaaaaggcaa accagaaacg ttcaacttcc
    20761 tcgggttcac gcacatcagc gggaaagatc gcaacggcag gttcatgctg atacgaaaga
    20821 cccgccggga tcggatgacg gcaactctga aagccatcaa agacggtctg cgaaggcgct
    20881 ggcattactc aatccccgaa cagggaaaat ggctcaggag agtggttcag ggatacctga
    20941 actatcactc ggtaccgggc aacttcccca ccatgcagaa gttcaggaca cacgtaacaa
    21001 acctctggcg ccgggcgctc aggcgcagga gccagaagga tgatacgacc tggacgaaag
    21061 caaacaaact ggcagcagcc gcatggctac caagggttcg ggttcttcat ccatggcctg
    21121 tggagcggtt caccgccaga cacccgaggc aggagcccgg tgcgtaaatc gcgcacgccg
    21181 ggatctgtgc ggggggtatc cggtaacggg tatccctacc gcattgttgc tgaaaaaggt
    21241 gattcacgtc cggctggttt tacagccggt ggtaactccc gtgaggccgt tattcgtttc
    21301 ccgaaagaga ccggacagaa gccggtttat gtgtcggtga cagatgttct taccccggca
    21361 caggtaaaac agcgtcagga ggaagaaaag cgtcgccagc aggcatggga cgccgctcat
    21421 ccggaagagg ggctgaaaag agactatgat aaagcgaaag ctgagctgga tgccgaagat
    21481 aaaaatattg cgaccttaaa cagccgcatt gcatcgacag agaaggcgct ccccggtgca
    21541 agggctgctg ttcaggaagc cgataaaaag gtaaaagagg cagaggcaaa taaagatgat
    21601 tttgtgactt ataacccgcc tcatgaatat ggctccgggt ggcaggatca ggttcgctat
    21661 cttgataagg atattcagaa tcagaatgag aaattaaaag cggctcaggc atctttaaac
    21721 gcaatgaatg aatccttatc cagagataag gctgcactta ccggggcgat ggagagccgg
    21781 aaacaaaagg agaaaaaagc gaaggatgca gaaaataagt taaatgagga aaagaacaag
    21841 cctcgcaagg gactaaagac tacggccatg attatcatcc agtacctaaa acagaagaca
    21901 taaagggact tggagagtta aagcgaggtg atctaaaaca cctaaacaag gtggtggtgg
    21961 taagcaggcc cgatggtatg gcgataaaaa acgtaaaatt tatgaatggg attcccagca
    22021 cggtgagctt gaagggtatc gtgccagtga tggcgaacac ctaggcgcat ttgatcccaa
    22081 aacgggtaag caggttaaag ggccagatcc aaaacggaac attaaaaaat atctttgaga
    22141 ggtaaatatg gggcttaaat tacgtttgac atggtttgat aagaaaactg aagagtttaa
    22201 agggaagagt attctaaaga ctttggtgac gatggttctg tcattgaaag cttgggaatg
    22261 cctttaaagg ataatattaa taatggtgag tttgatttga agaaagaatg ggttccttta
    22321 ctacagccat tttttaaaaa tcaaataaaa cctgatgtgg ataattgtta tatagctttt
    22381 gattatcggg acggtaactg gtaacaaaaa attatcaagg atgatttgaa atactgactt
    22441 ccggtgttca gggatgaatg ccggagtctt taaatacagg gaaagtatat gaaaaaggta
    22501 aagactattt ttctttttat attgattgtt gctggctttc ttctggccgc atgtcaggca
    22561 aattatatcc gggatgttca gggcggaacg gtggcaccat cgtcctcctc tgaactgacg
    22621 gggatcgcgg ttcagtagaa aagatcaaag gatcttcttg agatcctttt tttctgcgcg
    22681 taatctcttg cactgtaaac gaaaaaaccg cctggggagg cggtttgatc gaaggttaag
    22741 tcagttgggg aactgcttaa ccgggtaact ggctttcgca gagcacagca accaaatctg
    22801 tccttccagt gtagccggac tttggcgcac acttcaagag caaccgcgtg tttagctaaa
    22861 caaatcctct gcgaactccc agttaccaat ggctgctgcc agtggcgttt ttgcgtgtcc
    22921 gtccgggttg gactcaagat gatagttacc ggaaagggcg cagcagtcgg gctgaacggg
    22981 gggttcgtgc atacagccca gcttggagcg aacgacctaa accgagccga gataccagca
    23041 gcgtgagcta tgagaaagcg ccacgcttcc cgaaagggaa aaaggcggaa caggtatccg
    23101 gtaaacggca gggtcggaac aggagagcgc acgagggagc cgccggagag aaatcaccgg
    23161 catctttaag tcctgtcggg tttcgcccgt actgtcagat tcatggttga gcctcacggc
    23221 tcccacagat gcaccgaaaa agcgtctgtt tatgtgaact ctggcaggag ggcggagcct
    23281 atggaaaaaa cgccaccggc gcggccctgc cgttttgcct cacatgttag tcccctgctt
    23341 atccacggaa tctgtgggta acgttgtatg tgtccgcagc gcccgccgca gccgaacggc
    23401 aggagcgcag ctaccgagtg agcgaggagg cgcaatttcc ccggcacctg caagacggtc
    23461 accggacgcg ctgatgtggg atattgtccc ctgattaagt ctttctattc cctgacgatc
    23521 aattatcagg ataggtgaac catgtcggtt tttcgctgaa cattttacgt taacctatct
    23581 ctgttgcttt tttctccttg cggagaaatg caagtcatcc ccgctggggc gtggctgact
    23641 tcaggggaaa agaccttgct tacgctggct ggacgccacc gacgcacggt cttttcccct
    23701 ctttctggct ctgtccggct ggacgccggc cacgccagaa attcacccgg cccccgtcag
    23761 gctcacgcct gaccacccac aaaaatccac ggtgctggac gcacctgacg aagcaacaaa
    23821 gctgctcctg atttgcgggt ggtcagccgc tctatggcga actctgacgg ggccggaacc
    23881 tggaaaagac cgcactgggg tgccgccttt tctctcacgc gctgggcgtg ctcgttgttc
    23941 ctccggggct gcgccttttt ccgcatgggg cggaaagagg ctggcctccg cggtgaaagc
    24001 tgaacgcaat caccacggac gtgaccgccg ccgccatgcc ttggggcatg tccgcggcaa
    24061 tgcagcaggg gctgcgcatc acgccagtaa acccgtcgtc tgaaggagag agattgcatg
    24121 tttaatacgg attcgcttgc ctggcagtgg catatcccgg agctggcccg gcagatttac
    24181 ccgtgggtca gctggctgta ccggggtatt acagtctggc cggtttttct ggttatcggc
    24241 ctgtttttcg gtctggctga actctgggcc ggccgaatgc gtttttgggg ctgagccata
    24301 aggcgcggcg ggagtatgcc gatcgctata agcgcgataa taaccggact gtgccatttt
    24361 cggtgctggc ctcgctggat tcacccgggc ggatggtcag ggcacggcga catgtctgga
    24421 actacgcgta ctggctgacc ggcgctgccg gtctggcccc ttctgggggc tggttgtcgc
    24481 cgtgtttatc ggctgggaga aaccgtcctg cgcccggacc tctatgcgaa cgcagattat
    24541 tacctgctgc agccggctaa cctgttcggg atagcctggt gtgccggagg gcttgtcgcc
    24601 ggcgtccttc tggcgcggct gctggcgttc ctgctgcttg atggtcattt gcggccgctg
    24661 acgaggcggt gaacgcgaaa ctgaatcagg agagccggcg cagcgagcca gcggaccgga
    24721 gaaatgacag acgtccgcca cctgcatttc ggggagccgg taccggttaa cgcgctggcc
    24781 gatttttcca cggagcaggc ccggaaacag caggcggtgt ttctgggtaa ggatgagcag
    24841 ggccagccgg tgctggtccc tcgtgatacc tggcgcaaga ccaatattca gatcctcggc
    24901 ctgcccggga gcggcaagag cgcgatggcc accaacgcgc tcattcgctg cgtacgcgat
    24961 ttcggggacg ctgtggtgta cttcgacccc aaaggggacg cgtgggcgcc gcacgtcttc
    25021 cgggcgcact gccggacttc accctgctgg atctgcggcc gggaaaccgg cgcagctgaa
    25081 tctgttccgc gatctcgacc agtacgccct gaagaatctg ctggttgccg ggttttaacc
    25141 tggtgagacc ggcgacgtgg cggaccacta ccgcatcagc gagcagaaag cggcgaagct
    25201 gattgcggag cagttcccgc agggggcaaa cattcagcag gtgctggcgg cggcgtacgc
    25261 gttgccggag gccctgaaaa aggacgtgaa ggggctgatc accaagctgg agaacgtggc
    25321 cgacctgagc gtcctgcaga cggacagcgg tatcgatgtg gcggggataa tcaacggcgg
    25381 cggctgcctg tacgtcatcg gctcgatgga cgatgaggcg gtgatccggg tgcagaagat
    25441 gctgtttgcc cgctgcgcgc aaatcatcat tgcgcgggat gagttccgga ggtggccgca
    25501 cgcgagcatc atgctcgatg agattaaata tctgctgtcg aagtacgtgc tgaacgctgg
    25561 ggacgctgcg cagccgggac tgcaacctgc tgctcgcgca ccagtcgctg ggcgacttcg
    25621 gtcagtgcgg gcaggatctg cccgctgatt ttgtgaaaac cacggtactg gataacacgc
    25681 cgatccgctg gttctatcgc gcggccagcc aggagtccgc gcagtgggcg gcaggccaga
    25741 ccgggagatc cgggtggacg tggagcgccg ccgccagccg ggaggcgggg aacgtggagc
    25801 acatcagcgg cgacagcttc atcagaagga ggcgcggccg ctgtttgacg tgaacaccct
    25861 gcaacacctg cctgacgggt tcgcggtgat gaccgggctg ggcgtggcgc ggctggcgtt
    25921 caagcagccc gctgcgggtt gagcgccggg aaatttcgct gaaaaccttc ccggtgctgg
    25981 cgaaaacgga cccgctggcg gagtacctgc ctccggccga cggcggcgga ccaaaagcgg
    26041 atgatgattt tgcggggctt tactgatgac actggagcag tacaacgtca gccacgcgaa
    26101 gcggcaggcg cggaacgcgg agaaaacacg gctgaccctg cgctggctgc gggaagagct
    26161 gtgttccacg gcggagctgg ttgcgcgacg gctggggatt gcggcggtac agccggttta
    26221 ccgcttcctg gacagtctgg tggcgaaagg gctgctggtc cgggcgaaat acccggttga
    26281 cggccgtcag gtcagcgtgt gggggctgac gccgcacggg gtggcgttct cgttcgacga
    26341 ggacgagccg ctgacggacg ttattccgtt tcagccgtca agggtgtcgg cggcgcagct
    26401 gccgcaccgg ctggccgtgc agtccctgcg cctctccatg gaggagccga aggggccggc
    26461 tggcggtacc tgcaccgtat ggccctgaaa gggatgaaag tgccggacgc gctggcggag
    26521 ctggacggca gaacggtggc atttgaggta gagcgcaccg tcaagagccg caggcggtat
    26581 caggaagtgg tgtccgggta tctgttcaac cgccgggcga acggcatcga tgaaatctgg
    26641 tacatctgcc ctgaccggcc gacgcttgtc cgggtacagc gggcgattct ggcggtggat
    26701 gaaatcgtga atccacagac ccgaggcccg caaaacggtg gagctggacc gggagaggct
    26761 gttcgcgtgc tttaaattta tgacgggtga ggattatggc gctgtacatg gtatttattg
    26821 aggacgtgga agacaaagac ggcgagcgct gcattatgcc aaccagcgag catctggaag
    26881 acatggtggt gctcgcctgg cagaccaggc gtatgttttc tgtttgtcga ccggagccca
    26941 gcatctggcg atgatgaaat ccatcgggat gtatgacgac ggctcaacag cgacgaaaaa
    27001 aagccacatg cttttcaccg gtgaaaatcc gcaatgggaa caggacaaac ccacaggaat
    27061 gactgtgcga ttactatcct cgaaggtgga gcggttcgcc atcgggaaca gtgtgccagg
    27121 tggttgatgc cggaagtgct caccggagca gattaacgcg atgattgaga attgatcgcg
    27181 aagcggcacg gggaaagcgc ggtgaacgaa gctgaaagcg gaacagtggg aataacagcc
    27241 gctattttaa cgtgcccggt gcctgaactg ccggaggaca a
//
