LOCUS       NZ_CP091002             8577 bp    DNA     circular CON 28-JAN-2024
DEFINITION  Staphylococcus epidermidis strain BC1191 plasmid pSEBC1191-4,
            complete sequence.
ACCESSION   NZ_CP091002
VERSION     NZ_CP091002.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN18740298
            Assembly: GCF_021513095.1
KEYWORDS    RefSeq.
SOURCE      Staphylococcus epidermidis
  ORGANISM  Staphylococcus epidermidis
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 8577)
  AUTHORS   Morand,S.C.
  TITLE     Staphylococcus epidermidis strain:BC1191 genome, complete sequence
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8577)
  AUTHORS   Morand,S.C.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JAN-2022) Advanced Research, L'Oreal, 1 Avenue Eugene
            Schueller, Aulnay-Sous-Bois 93600, France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: JAN-2022
            Assembly Method :: MaSuRCA v. 3.4.1; Unicycler v. 0.4.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 1809.0x
            Sequencing Technology :: Illumina HiSeq; Oxford Nanopore MinION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/28/2024 02:46:29
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,349
            CDSs (total)                      :: 2,266
            Genes (coding)                    :: 2,202
            CDSs (with protein)               :: 2,202
            Genes (RNA)                       :: 83
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 60
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 64
            CDSs (without protein)            :: 64
            Pseudo Genes (ambiguous residues) :: 0 of 64
            Pseudo Genes (frameshifted)       :: 37 of 64
            Pseudo Genes (incomplete)         :: 34 of 64
            Pseudo Genes (internal stop)      :: 25 of 64
            Pseudo Genes (multiple problems)  :: 26 of 64
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP091002.1.
            Bacteria and source DNA available from L'OREAL.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..8577
                     /organism="Staphylococcus epidermidis"
                     /mol_type="genomic DNA"
                     /strain="BC1191"
                     /host="Homo sapiens"
                     /db_xref="taxon:1282"
                     /plasmid="pSEBC1191-4"
                     /geo_loc_name="France"
                     /collection_date="2012-01"
     gene            complement(86..181)
                     /locus_tag="KB233_RS11615"
                     /old_locus_tag="KB233_11615"
     CDS             complement(86..181)
                     /locus_tag="KB233_RS11615"
                     /old_locus_tag="KB233_11615"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002501808.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="WP_002501808.1"
                     /translation="MLAIFVYITVSIFIECCVALFKFWLEQRNKK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            complement(455..1084)
                     /locus_tag="KB233_RS11620"
                     /old_locus_tag="KB233_11620"
     CDS             complement(455..1084)
                     /locus_tag="KB233_RS11620"
                     /old_locus_tag="KB233_11620"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002502719.1"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]; GO:0005524 - ATP binding [Evidence IEA];
                     GO:0016887 - ATP hydrolysis activity [Evidence IEA];
                     GO:0042626 - ATPase-coupled transmembrane transporter
                     activity [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_002498710.1"
                     /translation="MIQLKNVSKSFKDIYILKNINLTIKEKAFVVIKGKSGQGKSTLLN
                     ILGLLEAPTEGQIIYKNQSIASKSQIRKFKKEDIAYIYQNYGLLENKTVLANLMLPLNI
                     SKKDMPKIIEIIQSVGLPKEILKRKVYTCSGGEQQRIAIARAILKNPTVIFADEPTGNL
                     DEKNAHDVINIFQYLNRQGVTIIMATHSQNFFDIGTELIDLDVQNA"
                     /name="ABC transporter ATP-binding protein"
     gene            complement(1087..3129)
                     /locus_tag="KB233_RS11625"
                     /old_locus_tag="KB233_11625"
     CDS             complement(1087..3129)
                     /locus_tag="KB233_RS11625"
                     /old_locus_tag="KB233_11625"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002511322.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF1430 domain-containing protein"
                     /protein_id="WP_235083152.1"
                     /translation="MKKLLLFLLVSITLIFSLGIANSAKNLSFYQTIIKDHDHFVYNVP
                     GKEKKHTRDAPQYFNKIAKNHHVGLTKVTYFNDNRILFNTNEKRLLNQRDNHHQLHIFD
                     SKMHIDVENITTTKHLSAVGMYYIKGDPKDKATVLSLMNKYAGDTIKQENPSLLSYLTL
                     DQYTLALVFLLSLLIFIVYCHYLQRNKQNYKMLSDLGYDLTHHFMFVMRDLKWIFLSYV
                     LLSIGTTLITYLVIYKDLHILQLLAVVCSVMVLTLIALSCITILLLMIYQKDFYKNQVK
                     PNVNLIIYLYILLAIVMGVFLTTSTHQVIKNSHDFQSKIPSLKGWKNTKDVYQPNVQDN
                     GAEYNKEIEIAQDKRFDRLLKSKENPGFLIDTENFTSEGGELPLYIMNEKENNSIEPDG
                     KTIIVDPNYLKRHHMVTPQSEDVLRYIQHDKYTRNILVPIKFKRYEHKIRKNFTKDFKF
                     KRTLYDDIRKDHAPAHINIIYVKNNSKYPTYNSDAGGKNNKIEAPIAIVETGNTHVRNN
                     AHYMDDCYFFESKKDNPYDTLKPLLKKYGLLDDIISINSVYDTKVDDINDIKKEIIKYV
                     LLALITLISFIIAIFTAIHLYFVNWKHAIFIKYNLGYSVWNNHKYAFLLLAFVNILLLG
                     MFLQKYPITSLLIFISLLIFEMIVISIEFLILNQKNNNAILKGKE"
                     /name="DUF1430 domain-containing protein"
     gene            complement(3223..3615)
                     /locus_tag="KB233_RS11630"
                     /old_locus_tag="KB233_11630"
     CDS             complement(3223..3615)
                     /locus_tag="KB233_RS11630"
                     /old_locus_tag="KB233_11630"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002489797.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactococcin 972 family bacteriocin"
                     /protein_id="WP_002440650.1"
                     /translation="MKKQFLLASALTLGISGLGTIGYAQASMTDAHGGSENVDNSHGLK
                     ASKTYDNNVSTRSIKQGKKSGGYWVRGTTSKIVKSNYKHYSHKGHASVINGSGNGNSGG
                     WKKPGYWSKSSVKKTWSGNKAFYDHT"
                     /name="lactococcin 972 family bacteriocin"
     gene            complement(3746..4048)
                     /locus_tag="KB233_RS11635"
                     /old_locus_tag="KB233_11635"
     CDS             complement(3746..4048)
                     /locus_tag="KB233_RS11635"
                     /old_locus_tag="KB233_11635"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002455860.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_235083153.1"
                     /translation="MGNRIKPTVIEYPKEQTTLEDYEEDSKVSELESKINEYEELIQAQ
                     SHHIEELEQTVKHYQPQVDTFKRMLTHIDSTGYINFGSYKNDRLLLNQIRNSDKK"
                     /name="hypothetical protein"
     gene            complement(4127..4546)
                     /locus_tag="KB233_RS11640"
                     /old_locus_tag="KB233_11640"
     CDS             complement(4127..4546)
                     /locus_tag="KB233_RS11640"
                     /old_locus_tag="KB233_11640"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002511307.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_064588271.1"
                     /translation="MPKKQNSKEKILTIRVSQSQYKKICALADIREMNVTEYIRHTAIG
                     NRIKPTVIEQIKESSEVSELFKKDNEALKSNNQALQHHIHQLEDGIDQLRQENDVFHHL
                     LQHFDSTAFLNFNTYRDDRPLKNAIKRLKEQYKSK"
                     /name="hypothetical protein"
     gene            5036..6244
                     /gene="mobV"
                     /locus_tag="KB233_RS11645"
                     /old_locus_tag="KB233_11645"
     CDS             5036..6244
                     /gene="mobV"
                     /locus_tag="KB233_RS11645"
                     /old_locus_tag="KB233_11645"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002958641.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobV family relaxase"
                     /protein_id="WP_235083151.1"
                     /translation="MKLAWNTQKNKMSDVKGKEMEQERKGRIKNDEIDLKRTNLNFDLV
                     EDERHLYHRVKDRVDYYKEQGSRVQKNSVVMYSNIITLSKEEADRMGETRTKHYFKTCK
                     DYFSERFGEANVVSAKVHMDESAPHMHLHFIPVNHQGRLSARTAMNRQAIHHIHDELTT
                     HLCQQGFDVERGSTDDNKTYIQDIHEYKKKAKVLSELDQQIETKKQLLRDINDLHDEKE
                     HLTRDIQNLKRKNHFLQEDSQQAQEDIDLYKQLRTISRDDFKKEEEKYQKEIKAYEASL
                     SGLRMNYRDLDKRNQHLTTQNNQLEHHLDLLNARHQAMNDMVRNDTRILFAGLRCALKD
                     RNIELSAEIKYQRMPEVGIDPDTVDQGALTHAYQGDVSGIDHHIRKASAPIKKETENDL
                     ELE"
                     /name="mobV"
     gene            6918..7775
                     /locus_tag="KB233_RS11650"
                     /old_locus_tag="KB233_11650"
     CDS             6918..7775
                     /locus_tag="KB233_RS11650"
                     /old_locus_tag="KB233_11650"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001829553.1"
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006270 - DNA replication initiation
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RepB family plasmid replication initiator
                     protein"
                     /protein_id="WP_002501810.1"
                     /translation="MSGETVVYRNEMNLVPLRRFTSTEVDLFFTLCNKLKEQDTRKVII
                     PFEELKYLSNYYTRSQERFINDLEHVYDKMLNLTYVERNGRSFEKFVLFTSYKVDLDEE
                     CLSISVNPDLKHILNSITADFTKFELKEMTHLKSTYAKNMFRLLKQYKHTGYIKINISD
                     FKNRLDIPKTYQMNDITKRVLKPIINELSSIFNNLNINKIKAKKGRKIEWLEFTFDAEK
                     RIHNKRQPQMTNVGKQRQYISREKTPRWLEERTYEKNLKSEYDPQLEKERKAFLKQLQL
                     DWED"
                     /name="RepB family plasmid replication initiator protein"
     gene            complement(7823..8428)
                     /locus_tag="KB233_RS11655"
                     /old_locus_tag="KB233_11655"
     CDS             complement(7823..8428)
                     /locus_tag="KB233_RS11655"
                     /old_locus_tag="KB233_11655"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001076470.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_002498907.1"
                     /translation="MNKSKVAEIRKQKSLTQENLAEKAYVTVRTIQRMEAGEEVSSETL
                     KSVSNALDVTVNELFESISSSDKEEEIMEISKEQQKQFNYRKNELFTIKLITFSFIFVF
                     LGLFGIFVGELNGLEQNIYRIIWIFALFLSLAIMYYFLNVFISKKLDKKYPMTIGMKNR
                     NRKNEPVKNGWDFMARYWWIVFPIGGFLSWLIPELTGK"
                     /name="helix-turn-helix domain-containing protein"
     BGC             1..8577
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          6919..7678
                     /name="rep_cluster_1442"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="87.533"
                     /coverage="88.0"
                     /evalue="0.0"
     Typing          4965..6241
                     /name="MOBV"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="97.887"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 ttaacaaata ttgctagcat ttacgcacca aaccccagcc tactgcaata ggctggggtt
       61 tttcttcggt gttggctacg ccgtcttatt ttttattacg ttgctctagc caaaatttaa
      121 acaacgcaac acagcattct ataaaaatag atactgttat ataaacaaat atcgctaaca
      181 tttcatcgca ccccctctct acgtcaattt gacgtctgag agatagacga cctcaatagt
      241 ataacaaaat cttattttaa tggggttact gattttgaat aaagatacaa aagttctata
      301 aatgaaaata catgaaaacg tgtgatagag ggtatgtata aaatatgtat aatccatgaa
      361 ttgacataaa agggacaaac gctgaaatga cagcgtttgt cccttgtgtg tgagttgaca
      421 taataaagtg ttatgggtag ttaaattgta taggttatgc attttgaaca tctaaatcaa
      481 tcaattctgt acctatatca aaaaagtttt ggctgtgtgt agccataatg attgtgacac
      541 cttgtctatt taaatattgg aaaatattga taacatcatg agcgtttttt tcatccaaat
      601 tacccgtggg ttcatcagca aatataacgg taggattttt aagaatggct cttgcaatag
      661 caatacgttg ttgctctcca ccactacaag tataaacttt tcgtttaagt atctctttcg
      721 gtaatccgac agattgaata atttcgataa ttttaggcat atcttttttg gaaatattta
      781 atggtaacat aagatttgct aatactgttt tattttctaa taagccataa ttttgataaa
      841 tataggcaat atcttctttt ttaaactttc taatttgtga ctttgaagca atagattgat
      901 ttttataaat tatttgaccc tcagtaggtg cttctaataa acctaaaata tttagcaatg
      961 tagactttcc ttgaccactt tttcctttaa ttacaacaaa tgctttttct ttaatagtaa
     1021 ggtttatatt tttcaaaata tagatatctt taaatgattt agatacattc tttaattgga
     1081 tcatgattac tcttttcctt tcaaaatagc attgttattc ttctgattga gtattaaaaa
     1141 ttctatagag atgacgatca tttcaaaaat aagcaaacta ataaagatca ataaactggt
     1201 tataggatac ttttgtaaaa acataccaag taacagtatg ttaacaaatg ctaataatag
     1261 aaatgcatac ttgtggttat tccaaacgga atatcctaga ttatatttaa taaatattgc
     1321 atgcttccaa ttaacaaaat ataaatggat agctgtaaat atagcaataa taaatgaaat
     1381 taacgtaata agtgctagta gaacatactt aataatttct ttcttgatat cgttaatatc
     1441 atcgaccttc gtgtcataga ccgaattaat agaaattata tcgtccagta aaccatattt
     1501 ttttaatagt ggtttcaaag tatcataagg attatctttt ttactctcaa agaaatagca
     1561 gtcatccata taatgtgcat tgtttctgac atgcgtatta cctgtttcaa ctatcgcaat
     1621 aggagcctct attttattgt tcttgccccc tgcatcacta ttatacgtag gatactttga
     1681 attgtttttt acataaataa tattaatatg cgcaggggca tgatcttttc ggatatcatc
     1741 atataacgtg cgcttaaatt taaaatcttt tgtaaagttc tttctaatct tatgttcata
     1801 acgtttgaac ttaataggta ccaatatatt tctcgtatat ttatcatgtt gaatgtatct
     1861 caaaacatct tcactttgag gcgtaaccat atgatgtcgt ttaagataat tgggatcgac
     1921 gattattgtt ttaccatcgg gttctatact gttattttcc ttttcattca ttatatataa
     1981 tggaagttct ccgccttcac ttgtaaaatt ttcagtatct attaaaaaac ctggattttc
     2041 tttacttttt aataaacgat caaatctttt atcctgtgct atttcaattt ccttgttata
     2101 ctctgcccca ttgtcttgaa cattaggttg atatacatct ttcgtatttt tccaaccctt
     2161 aagtgaaggg attttagact gaaaatcatg actatttttt atgacttgat gtgttgaagt
     2221 cgttaaaaag acacccatta cgatggcaag taaaatataa agatagatta ttaggttgac
     2281 attaggtttg acttgatttt tataaaaatc tttttgatat atcattaaaa gaagtattgt
     2341 aatgcaactt agtgcaatca atgttaaaac cataacggaa catacgacag ctaataattg
     2401 taagatatgt aagtctttat aaatcactaa gtaagtgatc agcgtagttc caatagatag
     2461 taaaacataa cttaaaaata tccatttcaa atctcgcatt acaaacataa agtgatgagt
     2521 taggtcatat cctaaatctg aaagcatttt ataattttgt ttattacgtt gtaagtagtg
     2581 acaataaacg ataaaaatta acagacttaa taagaaaact aatgctaaag tatattgatc
     2641 taaagttaaa taagatagca agctaggatt ttcctgtttg atcgtgtccc ccgcatattt
     2701 gttcatgagt gaaagcacag tcgctttatc tttaggatcc ccttttatat aatacattcc
     2761 tactgcagac agatgttttg tagttgttat attttcaaca tcgatatgca ttttactatc
     2821 aaatatatgt aactgatgat gattatctct ttgattaagt aatctttttt catttgtatt
     2881 aaaaagaata cgattatcgt tgaaatatgt aactttagtt aaaccaacat gatgattttt
     2941 ggcaatttta ttaaagtatt gaggcgcatc ccgagtatgt ttcttttctt ttcccggaac
     3001 attataaacg aaatgatcat ggtcttttat gatggtttga taaaaagaaa ggtttttcgc
     3061 cgagtttgcg atgcctaaac tgaatatcaa cgtgattgag accaataaaa ataataataa
     3121 ttttttcata tgtataaata cctttcatag catgaattaa gacagaaaat tctttataaa
     3181 acgaattttc tgtcttaatt tcttgcttat ttaataatat gattatgtgt gatcataaaa
     3241 agctttgttt ccagaccatg tttttttcac agaagattta gaccaatacc ccggcttctt
     3301 ccagccgcca ctatttccat ttccacttcc atttataact gaagcatggc ctttgtggct
     3361 ataatgttta taatttgatt taacaatttt gcttgtagtc cctcttaccc agtatcctcc
     3421 tgacttttta ccttgtttta ttgaacgagt agaaacatta ttatcatagg tttttgaagc
     3481 ttttaaacca tgagagttat ctacattttc agaacctcca tgagcgtctg tcatagatgc
     3541 ctgtgcatag cctatagttc ctaagccact aatgccaaga gtaagagcag aagcaagtaa
     3601 aaattgtttc ttcatcaact taatcctcct ttgaattcat tacatttaaa acatatcata
     3661 gatatatttt acttcgctta attttacaaa atattaatcg aataaataaa tttaattaaa
     3721 gatttaaata tctagcgatt aagtattact ttttatcact gtttctaatt tgattaagca
     3781 ataaccgatc atttttataa ctcccaaaat taatatatcc tgtactatcg atatgcgtta
     3841 acatacgttt gaatgtgtct acttgaggtt gataatgttt gactgtttgc tctaattctt
     3901 ctatatgatg tgattgagct tgtataagct cctcatattc attgattttg ctttctaatt
     3961 cactaacctt tgaatcctct tcataatctt ctaatgtcgt ttgttctttt ggatattcaa
     4021 tgaccgtcgg tttaatacga ttacccacag cttttattaa aattattaca ccataagtca
     4081 gaagctactt aatataataa aagcaagtga tttataattt tataaatcac ttgcttttat
     4141 actgttcttt taatcgttta atcgcatttt ttagtggacg atcatcacga tatgtattga
     4201 agtttaaaaa tgctgtacta tcaaaatgtt gtaataagtg atgaaagacg tcattttctt
     4261 gtctcagttg gtcgattcca tcttccaact gatgaatatg atgctggagt gcctgattgt
     4321 tcgatttgag tgcctcgttg tcttttttaa acaattcact gacttcactg gattctttaa
     4381 tttgttcgat gactgtcggt ttaatacgat taccaatggc tgtatgacgt atgtattcgg
     4441 tcacattcat ctctcgaata tccgcaagtg cacaaatctt tttgtattgc gattgactta
     4501 cacgaattgt taagattttt tcttttgaat tttgtttttt tggcattgaa ccacctcatc
     4561 gttaatatat gataagcata catatgtgtg cttatcttta tattaatata acatacatat
     4621 gtgtgcttat ctttatatta atataacata catatgtatg ctaataaata tgtatgattc
     4681 gaggtggtat gagctaacat ttggcataca tcttttcaaa catatttgtt tgataatgcg
     4741 tatgtcattt gttagctata gaacggcatt caaaaatata tttttgaatg tagtgatggc
     4801 ctcgccagag cgaagataac tcttacattt gaatgtaaga gtatatcgag ctatactctc
     4861 attgcggaat cagcctcaca tgtttgaggc gtagcggtga gagtatccat cattttacat
     4921 aagcgaagca ttgtcgaagg tagacaatca cagcgcttgt aaaatgatat ttgcgaaggt
     4981 tctcgaaagt agagaaccac agacaaatca aaaagcttcg gggagggcgc tcaatttgaa
     5041 attagcttgg aatacgcaaa aaaataaaat gagcgatgtt aaaggcaaag agatggaaca
     5101 agaacgtaaa gggagaatca aaaacgatga gattgatttg aaacggacaa acttaaactt
     5161 tgatttagtt gaagatgaac gtcatttgta tcatcgtgtg aaagatagag tcgattatta
     5221 taaagaacag gggtcacgtg tacagaaaaa tagtgtggtg atgtattcca atatcattac
     5281 gttatcgaaa gaagaggccg accgtatggg agaaacacgt acaaaacact actttaagac
     5341 atgtaaagat tacttcagtg aacgttttgg tgaagccaat gtcgtttcag cgaaagtgca
     5401 tatggatgaa tcagcgcctc atatgcacct tcactttata cctgtgaatc atcaaggacg
     5461 gttatcagca cgtacagcta tgaatcggca agccattcat cacatccatg atgaattaac
     5521 aacacatctg tgccagcaag gttttgatgt tgaacgtggg agtaccgatg ataataaaac
     5581 gtatattcaa gatattcatg aatacaaaaa gaaagcgaaa gttttaagtg aattagacca
     5641 acaaattgaa acgaaaaaac aattgttgag ggatatcaac gatttacacg atgaaaaaga
     5701 acatttaact cgggatattc aaaacttaaa acggaaaaat cattttttac aagaggattc
     5761 tcaacaggct caagaagata ttgacctata caagcaactg agaacgattt ctagggacga
     5821 ttttaaaaaa gaggaggaaa agtaccaaaa agaaatcaaa gcgtatgagg cgtctctgag
     5881 tggccttaga atgaattacc gagatttgga caagcgcaat caacatttaa caacacaaaa
     5941 taatcaactc gaacaccatt tagacctgtt aaatgcacgt catcaagcga tgaacgacat
     6001 ggtaagaaat gatacacgta ttttgtttgc gggacttaga tgtgcattga aagataggaa
     6061 cattgaatta agcgcagaaa ttaaatatca acgtatgcca gaagtcggta ttgatcccga
     6121 tacggtggat cagggggctt taacacatgc atatcaaggt gatgtgtcag ggatagacca
     6181 tcatataaga aaggcatcag cacctattaa aaaagagaca gagaatgact tagaattaga
     6241 ataaatcaat aaaaataagc actcaaacaa gtatgatact cgcctgagtg cttatctcat
     6301 gaaaagagga gataaaaatt taataagtat gatcaaccga ttaagaacaa tcattacctt
     6361 acttacagcg cttattaaat agttctgtaa ggaggaacaa tacctttgca tttctatatt
     6421 attataagaa ttctaaggta gcaaagatat tgtattggaa gtgatagatg tgagtatgat
     6481 ttctaaatta attgatgaag atattttggg tttctaaact taaaaaaata cctccattct
     6541 tttaaaagtt tatttttgtg ttgttttctt tataaatata tttgaatgcg tttgaagtat
     6601 ttcactccga cctttttaat atatttttat aaatcttttt aaaacctttt taagtactgt
     6661 ttaagaccta gagggacaag gcttttgaaa tgttaaaagg gacattttgt aacagtaaaa
     6721 gggacatttt gtaacagtaa aagggacatt ttgtaacagt aaaagggaca ttttgtaaca
     6781 gtaaaaggga cgtttttaaa attatgtcac ttatatgctt tatcctctat ataataggtg
     6841 ttataattcg tttgatcatt attatagagg gacgttttta aaattatgtc acttatatat
     6901 ttagagagga gttttttatg tctggtgaaa cagtagtata tagaaatgag atgaacttag
     6961 taccattaag acgttttaca agtactgaag tagatttatt ctttacatta tgcaataaac
     7021 ttaaagaaca ggatacaaga aaagtaatta ttccttttga agaattaaaa tatttaagta
     7081 actactatac gcgttctcaa gaacgcttta ttaatgattt agagcacgta tacgataaaa
     7141 tgttgaatct aacatatgtg gaacgtaatg gtaggtcttt tgaaaaattt gttttattta
     7201 cttcatacaa agtagattta gacgaagaat gtttatctat tagtgttaat cctgatttaa
     7261 aacatatttt aaattctata acagctgatt ttacgaaatt tgaattaaaa gaaatgaccc
     7321 atcttaaatc tacttacgct aaaaatatgt ttagattgct taaacaatat aaacatactg
     7381 gttatattaa aataaatata tctgatttta aaaatcgtct agatatacct aaaacttatc
     7441 agatgaatga tataaccaaa cgtgtattaa agcctataat taatgaactt tcttcaattt
     7501 ttaataatct taatatcaat aaaattaaag caaaaaaagg acgtaaaatt gagtggttag
     7561 agtttacgtt tgacgctgag aaacgtattc acaacaagcg acaacctcaa atgactaatg
     7621 taggtaaaca aagacaatat atcagtcgtg aaaaaacgcc gagatggtta gaagaacgta
     7681 cttatgaaaa aaatttaaaa agtgagtatg atccacaatt agaaaaagag cgaaaagcat
     7741 tcttaaaaca acttcaatta gattgggaag attaaaataa aagatcttta gcacacttgc
     7801 taaagatctt ttattttgta ttttattttc ctgttaattc aggtattaac caacttagaa
     7861 aacctccaat aggaaaaaca atccaccaat atctagccat aaaatcccag ccatttttta
     7921 caggttcatt ttttctattt ctatttttca ttccaatagt cataggatat tttttatcta
     7981 atttttttga aataaaaaca tttaaaaaat aatacattat tgctaagctc aaaaataaag
     8041 cgaaaatcca aatgatgcgg taaatatttt gttctaaacc gtttaactca cctacaaaga
     8101 ttccaaatag tcctaaaaac acaaaaataa aactaaatgt tattaattta atagtaaaaa
     8161 gttcattttt acgataatta aactgctttt gttgttcttt agatatttcc attatttcct
     8221 cctccttatc agaagacgag atagattcga atagttcatt gactgtcaca tctaatgcgt
     8281 ttgagacact tttaagtgtt tcactactaa cttcttctcc agcctccatt ctttgaattg
     8341 ttcttactgt tacataagcc ttttctgcta aattttcttg agttaacgat ttttgttttc
     8401 taatttctgc aacttttgat ttgttcatac tcataaacta ctcctcaact aaaaaaatga
     8461 acacgaaaaa ttgccgacag atgggcgaca atgaaacgac agttacttca aaattatatt
     8521 cttaaaagaa agtatatatc taattttaca aaaagcataa gaaaggatat actgaaa
//
