LOCUS       NZ_CP091000            11238 bp    DNA     circular CON 28-JAN-2024
DEFINITION  Staphylococcus epidermidis strain BC1191 plasmid pSEBC1191-2,
            complete sequence.
ACCESSION   NZ_CP091000
VERSION     NZ_CP091000.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN18740298
            Assembly: GCF_021513095.1
KEYWORDS    RefSeq.
SOURCE      Staphylococcus epidermidis
  ORGANISM  Staphylococcus epidermidis
            Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
            Staphylococcus.
REFERENCE   1  (bases 1 to 11238)
  AUTHORS   Morand,S.C.
  TITLE     Staphylococcus epidermidis strain:BC1191 genome, complete sequence
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 11238)
  AUTHORS   Morand,S.C.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-JAN-2022) Advanced Research, L'Oreal, 1 Avenue Eugene
            Schueller, Aulnay-Sous-Bois 93600, France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: JAN-2022
            Assembly Method :: MaSuRCA v. 3.4.1; Unicycler v. 0.4.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 1809.0x
            Sequencing Technology :: Illumina HiSeq; Oxford Nanopore MinION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/28/2024 02:46:29
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,349
            CDSs (total)                      :: 2,266
            Genes (coding)                    :: 2,202
            CDSs (with protein)               :: 2,202
            Genes (RNA)                       :: 83
            rRNAs                             :: 7, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 60
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 64
            CDSs (without protein)            :: 64
            Pseudo Genes (ambiguous residues) :: 0 of 64
            Pseudo Genes (frameshifted)       :: 37 of 64
            Pseudo Genes (incomplete)         :: 34 of 64
            Pseudo Genes (internal stop)      :: 25 of 64
            Pseudo Genes (multiple problems)  :: 26 of 64
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP091000.1.
            Bacteria and source DNA available from L'OREAL.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..11238
                     /organism="Staphylococcus epidermidis"
                     /mol_type="genomic DNA"
                     /strain="BC1191"
                     /host="Homo sapiens"
                     /db_xref="taxon:1282"
                     /plasmid="pSEBC1191-2"
                     /geo_loc_name="France"
                     /collection_date="2012-01"
     gene            complement(127..495)
                     /locus_tag="KB233_RS11500"
                     /old_locus_tag="KB233_11500"
     CDS             complement(127..495)
                     /locus_tag="KB233_RS11500"
                     /old_locus_tag="KB233_11500"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002503834.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3139 domain-containing protein"
                     /protein_id="WP_002494366.1"
                     /translation="MKKILKILITSIIVIIITLTVWTFSVITYQEHKSEKIIDHVIERK
                     GWDKKIKNEKMSFNIMMGYAEKDIAFKDQPYSEYEYNVTPAPAPWTDDKEYKVWGETDL
                     QKKDSYYKYLLESEPYRK"
                     /name="DUF3139 domain-containing protein"
     gene            599..994
                     /locus_tag="KB233_RS11505"
                     /old_locus_tag="KB233_11505"
     CDS             599..994
                     /locus_tag="KB233_RS11505"
                     /old_locus_tag="KB233_11505"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002502726.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3139 domain-containing protein"
                     /protein_id="WP_002494367.1"
                     /translation="MKRKYKITGIIFIVLLIVLTLIFSIVHHYANVQKHEEAKLKQKVH
                     HIFKQKGWEDKVKEEKNIFTFNTGDNDLQVTFKDEPYNTYTYSIDEDNKVYGNAVLKDE
                     YDKDFDSKKKYKEYLRKMHFEEKYDLK"
                     /name="DUF3139 domain-containing protein"
     gene            1228..1407
                     /locus_tag="KB233_RS11835"
     CDS             1228..1407
                     /locus_tag="KB233_RS11835"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001829546.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001829546.1"
                     /translation="MKSIVHFICLFIIFCIFGYVIDLIFFKEINIFLILESAFILSLLI
                     MPILKIVKEIEIEK"
                     /name="hypothetical protein"
     gene            1605..2054
                     /locus_tag="KB233_RS11510"
                     /old_locus_tag="KB233_11510"
     CDS             1605..2054
                     /locus_tag="KB233_RS11510"
                     /old_locus_tag="KB233_11510"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002494368.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002494368.1"
                     /translation="MKKLLSVFIASLLVLTGLSFSSINQGNTASAKTKYKTTITYKGQK
                     YVYVGHYKHHFSKKEVKKVVKFSKGVHSGNKLVSAASKLSKNGYVKASSAIYKAFDFGL
                     KNELKGSYFYTAAKKGTGVTISYDMYTATTGPNHTIAKNFKHSYN"
                     /name="hypothetical protein"
     gene            complement(2214..2600)
                     /locus_tag="KB233_RS11515"
                     /old_locus_tag="KB233_11515"
     CDS             complement(2214..2600)
                     /locus_tag="KB233_RS11515"
                     /old_locus_tag="KB233_11515"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002494369.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002494369.1"
                     /translation="MKKAIFSIIISLILVLTVTGCSNSSKEKPIKKSALEINPTSKAVN
                     ITINKKENNKPEKIGKVYRYKNNNAKEITNDGIKKDTKDTLIWKGVANKYDNVKDLLGE
                     SILYEVKYKNGDIKKFERKIKYTE"
                     /name="hypothetical protein"
     gene            complement(2620..2781)
                     /locus_tag="KB233_RS11520"
                     /old_locus_tag="KB233_11520"
     CDS             complement(2620..2781)
                     /locus_tag="KB233_RS11520"
                     /old_locus_tag="KB233_11520"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_162153024.1"
                     /translation="MNEREQRQKLNITLPPKLITNLDKVKTKYGINKSKQIENLISKYL
                     NEEYGNLE"
                     /name="hypothetical protein"
     gene            3630..4004
                     /locus_tag="KB233_RS11525"
                     /old_locus_tag="KB233_11525"
     CDS             3630..4004
                     /locus_tag="KB233_RS11525"
                     /old_locus_tag="KB233_11525"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002467994.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002494371.1"
                     /translation="MKKIVYILGTIIVLGFCYFYVNLIFFDSWTRYSAEKEINNYISNH
                     DTKKLKEISANNKTYQLLKHAKHVTIKGDTDNQGGGHIGYFTSTINGKEGALFVHLNFG
                     LFPEIPKVTKLEVFDKNIYE"
                     /name="hypothetical protein"
     gene            complement(4595..5047)
                     /locus_tag="KB233_RS11530"
                     /old_locus_tag="KB233_11530"
     CDS             complement(4595..5047)
                     /locus_tag="KB233_RS11530"
                     /old_locus_tag="KB233_11530"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002494373.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_235083150.1"
                     /translation="MPKKQSSKEKILTVRVSQEQYKKIQDLAYIRSMNVTEYIRQTAVG
                     NRIKPTVIEYPKEQITMDDSNSKNNTNNLYKVIEHLEEDNEALKSDRDALRQRHDQLED
                     DIEQYKRENEIFHRLLEHFDSTAFMNFNTYRDDRPLKKEIKRLKEH"
                     /name="hypothetical protein"
     gene            5502..6710
                     /gene="mobV"
                     /locus_tag="KB233_RS11535"
                     /old_locus_tag="KB233_11535"
     CDS             5502..6710
                     /gene="mobV"
                     /locus_tag="KB233_RS11535"
                     /old_locus_tag="KB233_11535"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002958641.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobV family relaxase"
                     /protein_id="WP_235083151.1"
                     /translation="MKLAWNTQKNKMSDVKGKEMEQERKGRIKNDEIDLKRTNLNFDLV
                     EDERHLYHRVKDRVDYYKEQGSRVQKNSVVMYSNIITLSKEEADRMGETRTKHYFKTCK
                     DYFSERFGEANVVSAKVHMDESAPHMHLHFIPVNHQGRLSARTAMNRQAIHHIHDELTT
                     HLCQQGFDVERGSTDDNKTYIQDIHEYKKKAKVLSELDQQIETKKQLLRDINDLHDEKE
                     HLTRDIQNLKRKNHFLQEDSQQAQEDIDLYKQLRTISRDDFKKEEEKYQKEIKAYEASL
                     SGLRMNYRDLDKRNQHLTTQNNQLEHHLDLLNARHQAMNDMVRNDTRILFAGLRCALKD
                     RNIELSAEIKYQRMPEVGIDPDTVDQGALTHAYQGDVSGIDHHIRKASAPIKKETENDL
                     ELE"
                     /name="mobV"
     gene            complement(7468..7623)
                     /locus_tag="KB233_RS11540"
                     /old_locus_tag="KB233_11540"
     CDS             complement(7468..7623)
                     /locus_tag="KB233_RS11540"
                     /old_locus_tag="KB233_11540"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002498916.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="beta-class phenol-soluble modulin"
                     /protein_id="WP_018113591.1"
                     /translation="MEHISKLGEAIVNTISASQSGDSAELAKSIVNIAANGIGVISDVA
                     KAFGLM"
                     /name="beta-class phenol-soluble modulin"
     gene            8131..8997
                     /locus_tag="KB233_RS11545"
                     /old_locus_tag="KB233_11545"
     CDS             8131..8997
                     /locus_tag="KB233_RS11545"
                     /old_locus_tag="KB233_11545"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002494364.1"
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006270 - DNA replication initiation
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="RepB family plasmid replication initiator
                     protein"
                     /protein_id="WP_018113587.1"
                     /translation="MTGETVVYKNDLNLVPLRKFTSTEINLFFAMCNKLKEKETNTLHL
                     SFDELKELSNYSPKTRNINRFVKDLDDVYKKMLELTIRYEDDEVIERFILFNHYRIHKK
                     DQYLEISTSPNLKHILNSITSNFTKFELKEMTNLKSTYSKNMFRILKQYKHTGYMKIKI
                     DDFRERLDIPKSYRMTDINKNVLKPIVTELNAIFNNLHINKIKAKKGRKIEWLEFIFDP
                     EKRIHNKRQPQMTNVGKQRQYINREKTPEWLNEGRLGQSQEIHNEDSKLRQDREAFQRQ
                     LEEKWEE"
                     /name="RepB family plasmid replication initiator protein"
     gene            9665..10231
                     /gene="lepB"
                     /locus_tag="KB233_RS11550"
                     /old_locus_tag="KB233_11550"
     CDS             9665..10231
                     /gene="lepB"
                     /locus_tag="KB233_RS11550"
                     /old_locus_tag="KB233_11550"
                     /EC_number="3.4.21.89"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002503824.1"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009306 - protein secretion [Evidence IEA];
                     GO:0006465 - signal peptide processing [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="signal peptidase I"
                     /protein_id="WP_018113588.1"
                     /translation="MKKEFKEWLIAIIVAILLLFLVNNFLFKPYTVSGLSMYPTFNNKD
                     KVVVSKISKSLNHLKSGDVIIFHQNSNNDFIKRLIGKPGDQIEYKNDKLYINKNYIKEP
                     YLDYNKKMNNSSENLTEDFNVSNIKGSKHKMIIPKDKYLVLGDNRTNSIDSRYSEVGLI
                     SKKQIVGKVILRFWPFNDMKYNFKR"
                     /name="lepB"
     gene            complement(10432..10530)
                     /locus_tag="KB233_RS11555"
                     /old_locus_tag="KB233_11555"
     CDS             complement(10432..10530)
                     /locus_tag="KB233_RS11555"
                     /old_locus_tag="KB233_11555"
                     /inference="COORDINATES: protein motif:HMM:NF033608.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="WP_309498286.1"
                     /translation="MMYLIFVFIIAPIIVECSVTLFKYWLEQRNKK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            complement(10870..11235)
                     /locus_tag="KB233_RS11560"
                     /old_locus_tag="KB233_11560"
     CDS             complement(10870..11235)
                     /locus_tag="KB233_RS11560"
                     /old_locus_tag="KB233_11560"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020368092.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002494365.1"
                     /translation="MKWLKIIILILSLVPIEFIGLFTDYQTGLLIGYIPFIIVAILISR
                     SIFKFGLKNNISIIISRCIGTFLSWECVHWFMNIYDSSDYFKPLTTDIFALFLGAIHFI
                     VIMLIYLVIYGFSHRNN"
                     /name="hypothetical protein"
     Typing          8132..8997
                     /name="rep_cluster_1439"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.885"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          5431..6707
                     /name="MOBV"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="97.887"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 aaaatttctc ttttcaatat tatttttcct tcaatatcat tttattaata taattaggta
       61 aaagtctacg ctgtctttaa gtgatagatg aatgatctct attttttatt atgttataca
      121 tttatattat tttctgtaag gttctgattc taaaagatat ttataatagg agtctttctt
      181 ttgtaaatct gtttcccccc ataccttata ttctttatca tctgtccatg gtgctggtgc
      241 tggtgtcacg ttatactcat actcactata tggttgatct ttaaaagcaa tatctttttc
      301 agcatatccc atcataatat taaaactcat tttttcattt tttatttttt tatcccaacc
      361 cttacgttct ataacgtgat cgatgatttt ctcactcttg tgttcctgat aagtaatcac
      421 actaaaagtc caaactgtta aggtaataat gataacaata atagaagtta ttaatatttt
      481 taagattttc ttcatttttg tataattcct cttttttaat aatttttatg ataaatatgt
      541 attattgtat ttaattttac aaaatattaa ttaaataaat ttacttaagg agactaatat
      601 gaaaagaaaa tataaaatta caggtatcat ctttatcgtt cttcttatcg ttttaacatt
      661 aatttttagt atagtgcacc attatgctaa tgttcaaaaa catgaagaag ctaaactaaa
      721 acaaaaagtt caccatattt tcaaacaaaa aggttgggaa gataaagtta aagaagaaaa
      781 aaatatattt acgttcaata ctggagataa tgatttacaa gtcactttta aagatgagcc
      841 ttataatacg tatacatatt ctattgatga agacaataaa gtatatggaa atgctgtttt
      901 gaaagatgaa tatgataaag attttgatag taaaaaaaag tacaaagaat atttaagaaa
      961 aatgcatttt gaagaaaaat atgatctgaa ataaaaaagc aagcgactac gataattgat
     1021 agtcgcttgc tttttagtgt tctttcaatt tgtttaatgc ttttttatga ttcgttttct
     1081 atcttgtaat ttggaggctt atatatgcca ttttaaaagc atatgcgcgt ctttaatatg
     1141 aaatatacta aaattaccta tatgatatta aatgaaaagc ctgtataaag tttaaaatag
     1201 cttagaaagc aaaaaggagt attagcattg aaatcaattg ttcattttat ttgcctcttt
     1261 atcatatttt gtatttttgg atatgtgata gatttaatat tttttaaaga aataaatatt
     1321 tttctgattt tagaatcagc ctttatttta tcattactaa tcatgccgat attaaagatt
     1381 gtaaaagaga tagaaattga aaaatagaac tggtaaatac cattttctat acttaatgtt
     1441 taataaaaat aggctactaa aattcagtta ataaagatcc atctttatta actgaatttt
     1501 aaaaaaaata tatagtgtta atttttttaa ttaaagtagt tataacttaa tttatatgat
     1561 aaagtcatat ttaaacatat aaatatttta caggaggtct ttttatgaaa aagttacttt
     1621 cagtttttat tgcaagttta ttagttttaa ccggattatc tttttcttca attaatcaag
     1681 gtaatactgc gagtgctaaa acaaaatata aaacaactat aacttacaaa ggtcaaaaat
     1741 atgtatatgt tggtcattat aaacaccatt tttctaaaaa agaagttaaa aaagtagtta
     1801 aattttctaa aggagttcat tcaggaaaca aattagtatc tgctgctagt aaacttagta
     1861 aaaatggtta tgttaaagca tcctcggcta tttataaagc ctttgatttt ggattgaaaa
     1921 atgaattaaa aggtagctat ttttacacag cagctaaaaa aggtacaggc gtaacaattt
     1981 cttatgatat gtatactgca acaacaggtc cgaaccatac tatagctaag aattttaaac
     2041 atagttataa ttaaataaat gtgaggggaa ggattaatcc ttcccctcac atttattttc
     2101 aagctttttt gaacggttga attttagacc ataatttatg aattcataga tattagataa
     2161 tatttcagct attattctta aaatattttc cattatcatc actactttca attttattca
     2221 gtatatttaa tttttctctc gaattttttt atatccccat ttttatattt aacttcataa
     2281 agaatacttt ctcctaataa atcttttaca ttgtcgtatt tgtttgctac acctttccaa
     2341 atcaatgtat ctttagtatc ttttttaata ccgtcattag taatttcttt tgcattgtta
     2401 tttttatatc gatacacttt cccaattttt tcaggtttgt tattttcttt tttatttatt
     2461 gtaatattaa cagctttact tgtaggatta atttctaatg cacttttttt aattggtttt
     2521 tctttagaac tattactaca tccagtaaca gttagaacta aaataagaga aataataata
     2581 ctaaatattg cttttttcat tctaatcatc cttttttgct tattcaagat taccatattc
     2641 ttcatttaaa tattttgata ttaaattttc aatttgttta gatttattaa taccatattt
     2701 tgttttaact ttatctaaat tagttattaa tttaggagga agagtaatat ttaacttttg
     2761 tctttgttct ctttcattca aacccacaac actctccttt tatttatgcg tataaagtag
     2821 cattacatgc gtacaaagtc aagtttgtac ccataaaaga agtatagtat agtttgtttt
     2881 ttactttatg gagctattat aattacgaca aacgataaaa gaaaaacaat tttttcctct
     2941 caaaaaagcc ctatagtttt caactaagaa taaatgagca aagcaaatgg taagatagtc
     3001 cttcagctat gctgaatact accttaggcg gtaatggatt tccttatgct ctttaaaata
     3061 caaaagttac attatatacc tactttttca ggttttagct tttttctaag aagaacaatt
     3121 gagataaaaa atatattttc ctttctgaaa gtgttgagaa agaaatttta aaatgattta
     3181 tagcctatct gttgaacaaa aaagttttta gtcatttttt aataaaatgt tctagaaagg
     3241 gcttaaaatg caaaataaaa agactactca aaaaatgagt agtctgaaga atagtttttg
     3301 atgtattaaa tgaaagggag tactacatta atcatatcac acgcatttat accgagaaaa
     3361 tttattgatg ttgagaagaa cccttaacta aacttgaagc cgaatgtcgg catagcgtaa
     3421 gctattaagc cgacgattcg ataagtttag ggattgttaa agattcggag gttcaacgtc
     3481 aataaagcaa tttaaaacta tagttaaaat agggttctgt tgcaaagtca gaaagataag
     3541 tatataacct tatgtttctg actttgcaac agaaccactt taatttacca taaaaactta
     3601 aatattttga ggagataagg agtctttaaa tgaaaaaaat agtttatata cttggtacta
     3661 ttatagtttt aggcttttgt tatttttatg taaatttaat tttttttgat agttggacac
     3721 gttattctgc tgaaaaagaa ataaataatt atatttcaaa tcatgataca aagaaactga
     3781 aagaaatatc cgcgaataat aaaacatatc aacttttgaa acatgctaaa catgtgacaa
     3841 taaaaggaga tacagataat caaggtggag gtcatatagg gtattttact agtacgatta
     3901 atggtaaaga aggagcgctt tttgtacatc ttaattttgg tttgtttcct gaaattccta
     3961 aagtaaccaa gttggaagtt tttgataaaa atatttatga gtagcataat tgctactcat
     4021 ttttcgtgtt agttattctg gttctgttgc aaagttagaa aaatatagct aattacgtcc
     4081 atatagcatt aagcttctat gctatgataa tcgttagaaa tctggctaag aatctggagt
     4141 gtttttatga tttttttaag agaaaaaata gtcatgaaat atacaaaaaa atcatgtata
     4201 ttttgttaaa tagtacagtg atagcattta tattattgct aattgtgaaa ttaatatttg
     4261 atttcctttt ttagactata ttcatatttt ttcagatttg tatttttatt ggggttaatt
     4321 attggtagta tcccagattt tatagaaaag aaaggttaat tttatgttat taaaaaataa
     4381 gatttattca ggcattatta ttgttatttt tatagtttgt ttgattatag gattgaatga
     4441 aaatatcatt ggaaatcctt taggagaaaa aatattttat ttattaggtt ttctattttt
     4501 tgtattatta attattggta caacaaaaaa tagaaagcat taatgtcttc tttttgcccc
     4561 atttcttacg ataaacattt tttgagtagc ctttttaatg ttctttcaat cgtttaattt
     4621 ctttttttaa tggtctatca tcacgatacg tattaaaatt cataaatgca gtactatcaa
     4681 agtgctctaa caagcgatga aatatctcat tctccctttt gtattgttct atatcatctt
     4741 caagttggtc atgacgttgt cgaagtgcgt ctctgtctga tttgagtgct tcgttgtctt
     4801 cttctagatg ttcaataact ttatacaaat tattcgtatt attcttagaa ttagaatcat
     4861 ccatcgttat ttgctctttt ggatattcaa tcaccgtcgg tttaatccga ttacccacag
     4921 ctgtttggcg tatatattct gtgacattca tactacgtat gtaggctaaa tcttgtatct
     4981 ttttgtattg ctcttgactg acacgaacgg ttaagatttt ttctttcgag ctttgttttt
     5041 ttggcattga atcacctcat aattaatata tgataagcat acatatgtgt gcttattttt
     5101 atattaatat aacatacata tgaatgctaa taaatatgta tgattcgagg tggtatgagc
     5161 taacatttgg catacagatt ttcaaacata tttgtttgat aatgcgtatg tcatttgtta
     5221 gctatagaac ggcattcaaa aatatatttt tgaatgtagt gatggcctcg ccagagcgaa
     5281 gataactctt acatttgaat gtaagagtat atcgagctat actctcattg cggaatcagc
     5341 ctcacatgtt tgaggcgtag cggtgagagt atccatcatt ttacataagc gaagcattgt
     5401 cgaaggtaga caatcacagc gcttgtaaaa tgatatttgc gaaggttctc gaaagtagag
     5461 aaccacagac aaatcaaaaa gcttcgggga gggcgctcaa tttgaaatta gcttggaata
     5521 cgcaaaaaaa taaaatgagc gatgttaaag gcaaagagat ggaacaagaa cgtaaaggga
     5581 gaatcaaaaa cgatgagatt gatttgaaac ggacaaactt aaactttgat ttagttgaag
     5641 atgaacgtca tttgtatcat cgtgtgaaag atagagtcga ttattataaa gaacaggggt
     5701 cacgtgtaca gaaaaatagt gtggtgatgt attccaatat cattacgtta tcgaaagaag
     5761 aggccgaccg tatgggagaa acacgtacaa aacactactt taagacatgt aaagattact
     5821 tcagtgaacg ttttggtgaa gccaatgtcg tttcagcgaa agtgcatatg gatgaatcag
     5881 cgcctcatat gcaccttcac tttatacctg tgaatcatca aggacggtta tcagcacgta
     5941 cagctatgaa tcggcaagcc attcatcaca tccatgatga attaacaaca catctgtgcc
     6001 agcaaggttt tgatgttgaa cgtgggagta ccgatgataa taaaacgtat attcaagata
     6061 ttcatgaata caaaaagaaa gcgaaagttt taagtgaatt agaccaacaa attgaaacga
     6121 aaaaacaatt gttgagggat atcaacgatt tacacgatga aaaagaacat ttaactcggg
     6181 atattcaaaa cttaaaacgg aaaaatcatt ttttacaaga ggattctcaa caggctcaag
     6241 aagatattga cctatacaag caactgagaa cgatttctag ggacgatttt aaaaaagagg
     6301 aggaaaagta ccaaaaagaa atcaaagcgt atgaggcgtc tctgagtggc cttagaatga
     6361 attaccgaga tttggacaag cgcaatcaac atttaacaac acaaaataat caactcgaac
     6421 accatttaga cctgttaaat gcacgtcatc aagcgatgaa cgacatggta agaaatgata
     6481 cacgtatttt gtttgcggga cttagatgtg cattgaaaga taggaacatt gaattaagcg
     6541 cagaaattaa atatcaacgt atgccagaag tcggtattga tcccgatacg gtggatcagg
     6601 gggctttaac acatgcatat caaggtgatg tgtcagggat agaccatcat ataagaaagg
     6661 catcagcacc tattaaaaaa gagacagaga atgacttaga attagaataa atcaataaaa
     6721 ataagcactc aaacaagtat gatactcgcc tgagtgctta tctcatgaaa agaggagata
     6781 aaaatttaat aagtatgatc aaccgattaa gaacaatcat taccttactt acagcgttta
     6841 ttaaatagtt ctgtaaggag gaacaatacc tttgcatttc tatattatta taagaattcc
     6901 aaggtagcaa tgatattgat ttaatatgag caaattgata ttggaagcaa aagaaaccca
     6961 ctcaaacgaa cgagtgggtt ttgaaaaatg atacgtatta acttgataaa attaatcatt
     7021 ttatagttta aagaaaagga atgcataatt atagtaacac aaattaatgt ttgttacact
     7081 agtagtgctg ctcaatatat aaagtagtaa accataacta ttcttcgcat ctcttgttaa
     7141 aaagttaatt ttttgctttg tacaaggaaa agcactcaaa attgagtgct tttttcatat
     7201 taaaattaaa ctttaaaaat taagacagcg acactgatat gtgtcgctgt cttaagatat
     7261 attatatgag ttcaaaagat atatagctat tgtagcataa tagtgttttt attaaaaaac
     7321 aagacgaaat agtttgaatt actgaataac ttatgtctta aatcttttaa tttatttaag
     7381 atacgttgtt attaagaaaa taaaaaaaga tataaatcaa ctaaataatt gatttatatc
     7441 ttcatatgta ttgatttaaa atacttacta cattaaacca aacgctttag caacgtctga
     7501 tattacacca ataccattag ctgcaatatt aacaattgat ttagctaatt cggcactatc
     7561 tccagattgt gatgctgaaa tagtattaac aatagcttca cctaattttg aaatatgttc
     7621 catgaaaaac aaacctcctt acatataaaa tcattactca aataaaataa catatattac
     7681 gataattctc ttctactttt aaataattgt aattaaattt acgttttctt aaaaataaat
     7741 aaagggattg caatgttgtt actattaaaa ttaataaaaa aactttgaat ataataatag
     7801 ctattttaca tggaattttt taatatcttt ttataaatct ttttataaac ctttttagaa
     7861 gtcgtttgag ctttagagcc acagcttatt tgagatgctt aaggagtagt tttgccacat
     7921 aaaaggagta gttttgccac ataaaaggag tagttttgcc acataaaagg agtagttttg
     7981 ccacataaaa ggagtagttt ttattataaa ccttcttttg ttaattgaca ttgttatcaa
     8041 agtgttttaa cgtgaaaata tcaattcaat aaggagtatc ataaaaaaat atgctcctta
     8101 ttgaaataat tatgttgagg tatctatata atgacgggag aaacagtagt atacaaaaac
     8161 gatttgaatt tagttccttt aagaaaattc accagtactg aaattaattt attttttgcc
     8221 atgtgtaata aacttaagga aaaagaaact aacacacttc atttatcttt tgatgaattg
     8281 aaagaattga gtaactatag tccgaaaaca cgtaatatta atagattcgt taaagacttg
     8341 gatgatgtat ataagaaaat gttggaacta acaattagat acgaagatga tgaggttata
     8401 gaaagattta ttttatttaa tcattataga attcataaaa aagatcaata cttagaaatt
     8461 tcaacttctc ctaatttaaa gcatatactt aattcaatta ctagcaactt tactaaattt
     8521 gaattaaaag aaatgacaaa tttgaaatct acatattcaa aaaacatgtt tagaatactt
     8581 aaacaatata aacacactgg ttatatgaaa attaaaattg atgattttag agaacgccta
     8641 gatatcccta aatcttatag aatgacagat attaataaaa atgttttgaa gcctattgtt
     8701 acagagttaa acgctatttt taacaatctt cacattaata aaatcaaggc taaaaaagga
     8761 cgtaaaattg aatggctgga gtttatcttt gatcctgaga aacgcattca caataaacga
     8821 cagcctcaaa tgaccaatgt aggtaaacag cgtcaatata tcaatcgtga gaaaacacca
     8881 gaatggttaa atgaaggaag attaggacaa tctcaagaaa tacataatga agattcaaaa
     8941 ttaagacaag atcgagaggc atttcaacgt caattagaag aaaaatggga ggaataataa
     9001 cttaaatgag ctacatctat attttgcttt tatttccttt aataatggga tttttcttat
     9061 cactaaaaga gaaaaagtat gataaaaaat gactaattca ctattgtaaa gaaaatacag
     9121 aattttatga gtaaaacttg taattttatt gcaagtgaag aaactacagt atatactgaa
     9181 actaataaat attgaactca tatatcaccg aaccccaacc tactgacata ggttgggttc
     9241 tttagtggta aggctatctt gacttattta ttgcggttgt ttagccaaaa catgaaaatc
     9301 gcaacaccgc atcctactat aatttgaata aagcattaaa aatggccact caacaatttg
     9361 agtggcattg aaatcgttaa ggagttactt acgttaaaaa aattaatgtt agttagggac
     9421 aattatatgt tttcacttta acacttattt atatttaact cactcaaaaa atatttaacg
     9481 ctggaaattt ttgccttttt tgaaacgagt ggaacgagtt cattctgttc ttgatagtaa
     9541 attttattat ttcaataaag aaaagacatc ataaataatg aactactttt ggtaggatat
     9601 taaaaatata agtgataacc taaaatagga taaagtttat aaaatctaaa aaggaaatta
     9661 tgtaatgaaa aaagaattta aggaatggtt aatagccata atagtagcta tattattatt
     9721 atttttagta aataattttt tatttaaacc ttatactgta tcaggattat caatgtatcc
     9781 aacgtttaac aataaagata aagtagtagt cagcaaaata tccaaatcat taaatcactt
     9841 aaagtctgga gatgttatta tatttcatca aaatagcaat aatgacttta taaaacgatt
     9901 gattggtaaa ccaggagatc aaattgaata taaaaatgac aagttatata tcaataaaaa
     9961 ttatatcaaa gaaccttacc ttgactataa taaaaaaatg aataactcca gtgaaaattt
    10021 aacagaagat tttaatgtat caaatataaa gggatctaaa cataaaatga taatacctaa
    10081 agataagtat ttagttctcg gagacaatag gacaaacagt attgatagta gatattctga
    10141 ggtggggtta atatctaaaa aacaaatcgt aggaaaagtt attttaagat tttggccttt
    10201 taatgatatg aagtataatt ttaagcgatg aatgataaaa aagataagtt ataaagctag
    10261 cttgagatat tgttgacgat tacataatta gttcgttcga atatctattt aattttacaa
    10321 atctatactt acaagatata ctgaaagtaa caaatattaa gtgcatcaaa acaccaatcc
    10381 cccaatctat tgcagtagat tgggggatct tttagtgttg actatgtcgt cttatttttt
    10441 attacgttgt tccagccaat atttaaacaa cgtaacactg cactctacta taataggtgc
    10501 tattataaaa acaaatatta agtacatcat tacacctcct tccgtcgaat ctatcgccgg
    10561 aagtaagacg acttcaatag tataacaaaa atttttaatt taaaacgata gtttaggact
    10621 tgccatatga ataaagatac aaaagttcac ttgatgaaaa agaatgaaaa cgcgtcgtta
    10681 aagggatgta taaaagttgt ataaagaaga atgatgacaa atagggacaa acgctgaaat
    10741 gacggcgttt gtccctaata tgttagttaa cataattact gattatgggt agtgcctttg
    10801 tataaatact caaaaacaca aacattgtta aattaatctt tgtgtccttt aatataagta
    10861 acataatagt taattattgc gatgagaaaa accatagata actaaatata taagcataat
    10921 aactatgaaa tgaatagctc ctaaaaataa tgcgaaaata tctgtagtaa gaggtttaaa
    10981 ataatctgat gaatcgtaaa tattcataaa ccaatgaaca cattcccaag aaagaaatgt
    11041 tccaatacat ctacttatta taatacttat attatttttt aagccgaatt taaaaataga
    11101 tctacttatt aatatagcaa ctattataaa tgggatgtaa cctattaata aacctgtttg
    11161 ataatcagta aataatccga taaattctat tggaactaaa gataaaatta atataatgat
    11221 ttttaaccat ttcatttt
//
