LOCUS       NZ_CP089005             6914 bp    DNA     circular CON 12-FEB-2024
DEFINITION  Klebsiella pneumoniae strain 56661 plasmid p56661-6.9, complete
            sequence.
ACCESSION   NZ_CP089005
VERSION     NZ_CP089005.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN23552368
            Assembly: GCF_021166135.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 6914)
  AUTHORS   Chen,L., Hao,M., Lin,Y. and Kreiswirth,B.
  TITLE     Whole genome sequencing of K. pneumoniae isolates
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6914)
  AUTHORS   Chen,L., Hao,M., Lin,Y. and Kreiswirth,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-DEC-2021) HMH-CDI, Hackensack-Meridian Health Center
            for Discovery and Innovation, 111 Ideation Way, Nutley, NJ 07110,
            USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 01-SEP-2021
            Assembly Method                   :: Unicycler v. v0.4.9
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100x
            Sequencing Technology :: Oxford Nanopore MiniION and Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/12/2024 03:45:38
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,968
            CDSs (total)                      :: 5,844
            Genes (coding)                    :: 5,674
            CDSs (with protein)               :: 5,674
            Genes (RNA)                       :: 124
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 88
            ncRNAs                            :: 11
            Pseudo Genes (total)              :: 170
            CDSs (without protein)            :: 170
            Pseudo Genes (ambiguous residues) :: 0 of 170
            Pseudo Genes (frameshifted)       :: 70 of 170
            Pseudo Genes (incomplete)         :: 104 of 170
            Pseudo Genes (internal stop)      :: 30 of 170
            Pseudo Genes (multiple problems)  :: 31 of 170
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP089005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..6914
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="56661"
                     /host="Homo sapiens"
                     /db_xref="taxon:573"
                     /plasmid="p56661-6.9"
                     /geo_loc_name="Russia"
     gene            join(5421..6914,1..612)
                     /locus_tag="LRZ77_RS26400"
                     /old_locus_tag="LRZ77_26400"
     CDS             join(5421..6914,1..612)
                     /locus_tag="LRZ77_RS26400"
                     /old_locus_tag="LRZ77_26400"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="TraM recognition domain-containing protein"
                     /protein_id="WP_042096180.1"
                     /translation="MKKLSLNWSGNVSQSIEKARTLAAEYSRRDVPDNAPADLRDSASQ
                     GLETSKGFALSGRLLQSELVYGSDVPLAQFGTVLIPLVLAFTTLLLYWLPAWLAFIPSV
                     LWALFAIMTGGFTLGWFAGVLALLLLWGSDISLFSMGGTAQMLQFGTGMTLTLISLAAL
                     PLCHLLRRAERFTIINDDAKAGAIILSASRQAKAREKQTERAARDTSPLIWLGEAQGVT
                     WEKGDIMAPDPASRVALSAADLSTGLLVLGGTGTGKTSGVFRPVIRQWCEHNCGGLLLM
                     DGKGQLPAELAESNRGITLLTPDNPETPVPLIDGLNAEEVAAVLVSVSGKGNDKGSDWT
                     FAAEKQFRFSALLVELAVSVQAAPWTLATIARCVSDTAFRDTLIEAVSARTETLSPELT
                     TAALDFWLKEYPELAKAEGYTSSVQGIVTAWLSPLVGHRKMHGWINAAGGVNPSDVLRG
                     ARYGIGIDSSVYGELCTAAVNGFIKKRLYNEATRRGDNWKADSTNTAAMIVMDEADVLL
                     DETDAGILPRGRSLGLNFVVGLQAVEQAEAAFGGTQNAPKALAMLAQLRSVVALSSTHH
                     TAQYVSDRVGFGLPLEPVSLSTVPDMRYTVLQRAAASPFNDEENEFRSSITLDIPHVIS
                     HTVGKMMDHKNAAGERLQLAKEPKPWISPQECNMLTATEGVAVVVLNRAGAPRRDAIEL
                     VPEYRAG"
                     /name="TraM recognition domain-containing protein"
     gene            complement(640..2079)
                     /locus_tag="LRZ77_RS26405"
                     /old_locus_tag="LRZ77_26405"
     CDS             complement(640..2079)
                     /locus_tag="LRZ77_RS26405"
                     /old_locus_tag="LRZ77_26405"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011382089.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobA/MobL family protein"
                     /protein_id="WP_153937069.1"
                     /translation="MAIARLSMKAGMKGRGADHSAYISREGKYANRLERGERLEATDHG
                     NMPEWAKDNPQQFWLAADAYERKNGTSYREMEIALPRELDSEQREALVRDWTEQELGDK
                     HAYQWAIHVPTAADGGEQPHVHLMFSERQRDGIERDPEQYFKRYNSRNPEAGGARKGYG
                     EHGGQPRTLEQRREELVALRGRWEAKANEHLERAGQRERIDMRSYTAQGKDAIPEKKQL
                     PSEWRDERKRAEILDFRAAKAEQEQAQKDAGKVLYEHNSAVEHYRGVVAAVPEHRLKNS
                     SPDSIALDLREKLVGQRVDSDPAVLAAREQEEKTGKALENARQERDKTRQEAEQQRQEQ
                     QRWEEENRMRRWLHDKGIKKDERYTGLQQQREKSEQQAQAAVQKEQQAEMQHRQAVTAR
                     EETETDVRQQANEKWFEHHHTAVKDAAAERQRELERQEREQQQAKQAEYQQLIAQQQRQ
                     REQEKEQEHTPERQHGRGMSM"
                     /name="MobA/MobL family protein"
     gene            2252..2710
                     /gene="traD"
                     /locus_tag="LRZ77_RS26410"
                     /old_locus_tag="LRZ77_26410"
     CDS             2252..2710
                     /gene="traD"
                     /locus_tag="LRZ77_RS26410"
                     /old_locus_tag="LRZ77_26410"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011382088.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein TraD"
                     /protein_id="WP_143550668.1"
                     /translation="MHENEWLEKRLAYIRGLNAPNEQQRLLLMLAQLPQPTPNDRRKLG
                     VLIRAEKAAERALKARADAAKVLNAERRAVRKARDHELYKAAGLMGVAGVVDRETGRLN
                     VDAGLLVGLLMELAAGTLPENLHQEALKSRGDAAIAAREKKNKTNQAG"
                     /name="traD"
     gene            3412..4113
                     /locus_tag="LRZ77_RS26415"
                     /old_locus_tag="LRZ77_26415"
     CDS             3412..4113
                     /locus_tag="LRZ77_RS26415"
                     /old_locus_tag="LRZ77_26415"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001281399.1"
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006270 - DNA replication initiation
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /protein_id="WP_153937068.1"
                     /translation="MSDLIAYKSNALIEASYKLTLQEQRFLLVCISRLKSGEDAPSPDE
                     QKTMLITAAEFHSAFPDMGRQNAEAKLKEAIDRLWDRSVIIKNEVKREEFRWVQYRAQY
                     FKGEAKVEITFSDAIMPYLTQLKGQFTRVVVKNVSSLSSTYSIRIYELLQQFRSTGDRT
                     IAIDDFRTMLAVEDKYQQFKDLNKMIIKPAIAELNEKSDLAVTVETVKKGRTVVALRFR
                     FKEDKQIKMAV"
                     /name="replication initiation protein"
     gene            4110..4235
                     /locus_tag="LRZ77_RS29790"
     CDS             4110..4235
                     /locus_tag="LRZ77_RS29790"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_255556175.1"
                     /translation="MNNETKKLTLDELLAQCNPDAGMSDEDRQWVNQPPAGDEIA"
                     /name="hypothetical protein"
     gene            4250..4513
                     /locus_tag="LRZ77_RS26420"
                     /old_locus_tag="LRZ77_26420"
     CDS             4250..4513
                     /locus_tag="LRZ77_RS26420"
                     /old_locus_tag="LRZ77_26420"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000072676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_042096185.1"
                     /translation="MNSTTHYENANFLRELAESLPRILPDGGADKAALLQRLANEELAQ
                     AEYDERVRAKVAAARADKRPGMSTAQLRQQLQGRYQELSNDL"
                     /name="hypothetical protein"
     gene            4503..4802
                     /locus_tag="LRZ77_RS26425"
                     /old_locus_tag="LRZ77_26425"
     CDS             4503..4802
                     /locus_tag="LRZ77_RS26425"
                     /old_locus_tag="LRZ77_26425"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010848978.1"
                     /GO_function="GO:0008657 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) inhibitor activity
                     [Evidence IEA]; GO:0042803 - protein homodimerization
                     activity [Evidence IEA]"
                     /GO_process="GO:0030541 - plasmid partitioning [Evidence
                     IEA]; GO:0051290 - protein heterotetramerization [Evidence
                     IEA]; GO:0009432 - SOS response [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_042096184.1"
                     /translation="MTYEIDWRPGAVEDMAALFEYLAENASLWDARNVTDRLIAATERL
                     EDYPRLYETDERYGEGVRRISLLGQHVLYEVNDELRRVNILAVVGQRQNPLSVR"
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            complement(4810..4971)
                     /locus_tag="LRZ77_RS26430"
                     /old_locus_tag="LRZ77_26430"
     CDS             complement(4810..4971)
                     /locus_tag="LRZ77_RS26430"
                     /old_locus_tag="LRZ77_26430"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_153937067.1"
                     /translation="MTEKKQSANARRQAAFKARQREAGRTQRVLWLTDEEVNAVKALLD
                     KMRGDERP"
                     /name="hypothetical protein"
     gene            5020..5409
                     /locus_tag="LRZ77_RS26435"
                     /old_locus_tag="LRZ77_26435"
     CDS             5020..5409
                     /locus_tag="LRZ77_RS26435"
                     /old_locus_tag="LRZ77_26435"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_153937066.1"
                     /translation="MKKLSVYSRLSRKAGAKIYPNSNPDVHLHKADRIIPVRQEYAGAA
                     AATAGRIAVEVERQTLRSMTYKRLYPWVLALSVLCLLPPFASLGVDMFHAKQAQAEMQR
                     QQKQQLEEMNRRQQERINRLRSGIY"
                     /name="hypothetical protein"
     Typing          3413..4113
                     /name="rep_cluster_1778"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="91.773"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(644..2079)
                     /name="MOBQ"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="98.539"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 gcggacagca caaatacagc ggccatgatt gtgatggatg aagctgatgt gctgctcgat
       61 gaaaccgatg ccggcattct gccgcgtggg cgctcactgg ggctgaattt cgtggttggc
      121 ttgcaggcag tggaacaggc ggaagccgct ttcggcggga cgcagaacgc gccaaaagcc
      181 ctggcgatgc tggcacagct gcgctccgtt gtcgcgctgt catcaaccca tcacaccgcg
      241 cagtatgtct ccgatcgtgt ggggttcggg ctgccactgg agccggtatc gctctccacc
      301 gtgccggaca tgcgctatac cgtactgcaa cgggcggcgg cctcaccgtt taacgacgag
      361 gaaaacgagt tccgcagctc gataacgctc gatattccgc atgtgattag tcatacggtt
      421 ggcaaaatga tggatcacaa aaatgctgcc ggcgaacgtc tccagctggc aaaagagcct
      481 aagccgtgga tctcaccgca ggaatgcaac atgctgacgg cgacggaggg cgtggccgtt
      541 gtggttctca accgcgccgg cgctccccgc cgcgatgcga tagagctggt tcccgaatac
      601 cgcgccggct gaaaaaaaag gcaccgcaag gtgccttttt tacatgctca ttccgcgccc
      661 gtgctgccgt tccggtgtgt gctcctgctc tttttcctgc tcacgttgcc gctgttgctg
      721 ggcgatcaac tgctgatatt cagcctgttt tgcctgctgc tgctcccgct cctgccgctc
      781 aagttcccgc tggcgttcgg cggcagcatc tttcacggcc gtatgatgat gctcgaacca
      841 tttttcattg gcctgctgac ggacatcagt ttcggtttct tcccgcgcag tgacggcctg
      901 ccggtgctgc atttctgcct gttgctcctt ctgcacggcg gcctgtgcct gctgctctga
      961 tttttcccgt tgctgttgca gtccggtata acgctcgtcc tttttgatgc ccttgtcatg
     1021 gagccagcgg cgcatccggt tttcttcttc ccatcgttgc tgctcctgcc gctgctgctc
     1081 ggcttcctgc cgggttttgt cccgttcctg ccgcgcattc tccagcgcct taccggtttt
     1141 ttcttcctgc tcccgtgcgg ccagtacggc cggatcgctg tcaacgcgct gcccgacgag
     1201 tttttctcgc aaatccagag cgatgctgtc cggtgaggag tttttcagcc ggtgctccgg
     1261 caccgcggcc acaacgccgc gatagtgctc taccgcgctg ttgtgctcat aaagcacctt
     1321 gccggcgtct ttctgtgcct gttcctgctc ggcttttgca gcgcggaaat ccagtatttc
     1381 tgcacgcttc cgctcgtcgc gccattcact cggtagctgc tttttttcag gaatggcgtc
     1441 cttgccctgc gctgtatagc tgcgcatgtc gatacgttcg cgctggccgg ctcgctcaag
     1501 atgttcgtta gctttggcct cccaacggcc gcgcagggcg acaagttcct cgcgccgctg
     1561 ctccagcgtg cgcggctggc cgccatgctc accgtacccc ttccgcgccc cgcctgcttc
     1621 cgggttccgg ctgttatagc gtttgaaata ctgctctgga tcgcgctcaa tcccgtcccg
     1681 ctgccgttcg gagaacatca ggtgtacgtg tggctgctca cctccgtcag cggcggtggg
     1741 aacgtggata gcccactgat aagcgtgttt gtcgcccagc tcctgctccg tccagtccct
     1801 gacaagcgcc tcacgctgtt cgctgtccag ctcacgaggc agggcgattt ccatctcacg
     1861 gtatgaggtg ccgttcttgc gctcatacgc atcggcggcc agccagaact gttgcggatt
     1921 gtccttcgcc cactccggca tattgccgtg gtcggtggcc tccagacgct ctccccgttc
     1981 cagacgattt gcatacttgc cctcacggga aatgtaggcc gagtggtctg cgccacggcc
     2041 tttcattccc gctttcatgc tgagtcgtgc aatcgccatt tctttaccct gtaaatttgg
     2101 ggtgtggggc ttgccccacc gcgcagtttc tcaccgaagg ggagaaacta ctaagcgcgc
     2161 cttccgaaaa tcgaagattt ccgagaagga tacaccctcc gccgcaactg tggtagtttt
     2221 atgcaggcac gaaacgagca gcgggggaaa aatgcacgaa aatgaatggc tggagaaacg
     2281 gctcgcatat attcgcggac tgaacgcacc gaacgaacag cagcgccttt tgctgatgct
     2341 ggcgcagttg ccccagccaa caccgaatga ccgccgcaag ctgggagtac tcattcgtgc
     2401 tgaaaaagcc gcagagaggg cgctaaaggc tcgcgctgat gccgctaaag tgctgaatgc
     2461 cgaacgtcgc gccgtccgca aagcgcgtga ccacgaactc tacaaggcgg ctggtctgat
     2521 gggcgtggcc ggcgtggttg accgtgaaac cgggcggctc aatgtggatg ccggcctgct
     2581 tgtcggattg ctcatggagt tggctgccgg tacactgccg gaaaacctgc accaggaagc
     2641 acttaaatct cgcggtgatg ctgctatcgc tgcccgtgag aaaaaaaata aaacgaatca
     2701 ggctggctaa tgaacctcac acttgtttgc caatagccct gagaagccgc agaaatcatc
     2761 ctgcggcttt tttttgcctt cgggtaggga aacgtacagg gaaaagaaaa aaacgcttac
     2821 agtgcgttat agggcgtttt agagcaatcc gccaatttag tgctggttcc cggctgtgac
     2881 gattgccgcc cctccatcct gaaaagactg gtttccccct tctctgccag tgaagcgaca
     2941 ccagatcctg acggtcgaag acgtacagcc tttcagcgat ttgcccgccc gtccgggcgg
     3001 gtgctacctc ctgccatagc gcgttattca cagggattta cggccattca gcgtcctgca
     3061 gaacaggtat attcataacc tactgtttat tttggcgttt tttttcgtgg cttcatttta
     3121 tccacagcgc cgccgttaag tttttaagat cttttttttt agatcttctt ttttaaaacc
     3181 tttttcggtc tcgtaagcca atgattctaa tcattttctg gcgagatagg tggaggtttt
     3241 gaaggtgata ggtggaggtt ttgaaggtga taggtggagg ttttgaaggt gataggtgga
     3301 ggttttgaag gtgtaatcca cagaaaatgg gggaggataa aaaaaaactt ccaccaatta
     3361 gataagtggc gtacagttaa aaaacaccac caatagcaac gagcaagcgg aatgtctgac
     3421 cttatagcct ataaatcaaa cgcccttatc gaggccagtt acaagctcac cttacaggag
     3481 cagcgcttcc tgctggtctg tatcagccgc ctgaaatccg gggaagatgc cccttcgccg
     3541 gatgaacaaa aaaccatgtt aatcacggcc gctgagtttc attcggcctt ccctgacatg
     3601 gggcggcaga acgctgaagc caagctcaag gaagcgatag atcgcctctg ggacaggtca
     3661 gtcatcatca aaaacgaggt aaaacgagaa gagttccgct gggtgcagta ccgggcgcag
     3721 tatttcaaag gtgaggcgaa agtagagatc accttctccg atgccatcat gccctatctg
     3781 acacagctca aggggcagtt tacgcgggta gtggtgaaga acgtctccag cctctccagc
     3841 acctacagca tccgcattta cgagctgctc cagcagttcc gtagtaccgg tgacagaacg
     3901 atagctatcg atgatttccg aaccatgctt gccgttgaag ataaatatca acaattcaaa
     3961 gatttgaata agatgataat caagccagcc atcgctgagc tgaacgaaaa aagcgatctg
     4021 gccgtcaccg tcgagacggt gaaaaagggg cgaaccgttg tcgcgttgcg gttccggttc
     4081 aaagaggaca agcagatcaa gatggccgta tgaataacga aaccaaaaag ctgacgctgg
     4141 atgaacttct ggcacaatgc aatcccgatg ccggcatgag cgatgaagat cgccagtggg
     4201 taaatcagcc ccctgccggc gatgaaatcg cgtgaatgga gatatgacca tgaacagcac
     4261 tacccactac gaaaacgcca attttctgcg cgaactggcc gagagcttgc cccgtattct
     4321 gccagatggc ggcgcggata aggccgctct gctccagcga ctcgctaacg aagaactggc
     4381 acaggctgaa tacgacgagc gggttcgcgc aaaggttgcc gccgcccgcg ctgacaagcg
     4441 gccgggcatg agtaccgcgc agctgcgcca gcagttacag ggacgctatc aggaactgag
     4501 caatgaccta tgaaatcgac tggcggccgg gggcggttga agatatggcc gccctgtttg
     4561 agtatctggc cgaaaatgcc tcgctatggg acgccagaaa cgtgacagac cgcctgatag
     4621 ccgccactga acgactggaa gattatcccc gtttgtacga gaccgacgag cgatacggcg
     4681 agggcgtccg gcgtatcagc ctgctcggcc agcatgtgct gtatgaggtg aacgacgagt
     4741 tacggcgggt aaacattctg gccgtggtcg gtcagcgtca gaacccctta tcggtacgct
     4801 gaaaacgcct tacggacgtt catccccccg cattttatcc agtaacgcct tgacggcgtt
     4861 cacctcttca tcggtcagcc acagcacccg ctgagtgcgg ccggcttctc tctgtctggc
     4921 cttaaacgcc gcctgacgcc tggcatttgc tgattgcttt ttctctgtca ttcgttacta
     4981 tccgatgcgt tactagtaac gcttaaggag tggtttctga tgaaaaaact gtctgtttat
     5041 tcacgtctta gccggaaagc cggcgcgaaa atatacccta acagtaaccc cgatgttcac
     5101 ctgcataaag cagatcgcat tatccccgtg cgccaggagt atgccggcgc ggccgccgca
     5161 acggctggcc gcattgctgt ggaagttgag cgccagacgc tgcgcagcat gacctataag
     5221 cgcctgtatc cgtgggtgct ggcgctgtcc gttctctgcc tgctcccgcc gtttgcctcg
     5281 ctgggggtcg atatgttcca tgcaaaacag gcgcaggcgg aaatgcagcg ccagcagaaa
     5341 caacagctgg aagagatgaa tcgccggcag caggaaagaa ttaatcgcct gcgcagcggc
     5401 atttactgag ggatcagaac atgaaaaaac tgtcacttaa ctggtctggc aatgtgagtc
     5461 agtccatcga aaaagcccgc acactggccg ccgaatactc ccgccgtgat gtacccgaca
     5521 acgcaccggc cgatctgcgc gactcggcca gtcagggact ggaaacgagc aaggggtttg
     5581 cgttgtctgg ccgtctgctg caaagcgaac tggtctacgg ttcagatgtg ccgctggcgc
     5641 agttcggcac tgtgctgatc ccgctggtac tggcgttcac aaccctgctt ctgtactggc
     5701 tcccggcatg gctggcattc attccgtccg tcttatgggc gctgtttgcc atcatgaccg
     5761 gtggttttac gctgggctgg tttgccggcg ttctggcgct gctcctgctc tggggatctg
     5821 atatttcgct gttttcgatg ggcgggacag cgcagatgct ccagtttggc accggtatga
     5881 cgctgacgct gatttcgctg gccgctctgc cgctctgtca ccttctgcgc cgcgccgagc
     5941 gctttaccat catcaacgat gacgctaaag ccggcgcaat cattctgtcc gcctcacgtc
     6001 aggcaaaagc ccgcgaaaag cagacagaac gagccgcacg cgacacctcg ccgctgatct
     6061 ggctgggtga ggcgcagggc gtgacatggg agaaggggga tattatggcg cccgatccgg
     6121 cgtcacgcgt tgccctgtcg gccgctgacc tgtccacggg attgcttgtt ctcggtggca
     6181 ccggcaccgg caaaacgtcc ggcgtgttca ggccggttat ccgtcagtgg tgtgagcaca
     6241 attgcggtgg cctgcttctg atggacggaa aggggcagtt accggccgaa ctggccgaaa
     6301 gcaacagggg aataacgctg ctgaccccgg ataacccgga aacgcctgtc ccgctgatcg
     6361 atggcctgaa tgccgaagaa gtggccgccg tgctggtttc tgtctccggc aaggggaatg
     6421 ataaaggctc tgactggaca tttgcggccg aaaaacagtt ccgtttttct gccctgctcg
     6481 ttgagctggc cgtcagcgtt caggccgcac cgtggacgct ggccactatt gcccgctgcg
     6541 tgtcagatac ggcattcagg gacacgctga ttgaggctgt aagcgcccgt acagaaacac
     6601 tgtcacctga actgaccacg gccgcactgg atttctggct caaggaatac ccggaactgg
     6661 caaaagccga agggtatacc agttctgtgc aggggattgt gaccgcgtgg ctttctccgc
     6721 tggtcggtca caggaaaatg cacggctgga ttaatgccgc cggaggggta aacccttctg
     6781 atgtcctgcg cggggcgcgg tacggcatag ggattgattc atcggtatat ggcgaactct
     6841 gcaccgcagc ggttaacggg ttcatcaaaa aacggctgta caacgaggca acgcggcgcg
     6901 gtgataactg gaaa
//
