LOCUS       NZ_CP088998             6796 bp    DNA     circular CON 12-FEB-2024
DEFINITION  Klebsiella pneumoniae strain 49088 plasmid p49088-6.796, complete
            sequence.
ACCESSION   NZ_CP088998
VERSION     NZ_CP088998.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN23552369
            Assembly: GCF_021166155.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 6796)
  AUTHORS   Chen,L., Hao,M., Lin,Y. and Kreiswirth,B.
  TITLE     Whole genome sequencing of K. pneumoniae isolates
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6796)
  AUTHORS   Chen,L., Hao,M., Lin,Y. and Kreiswirth,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-DEC-2021) HMH-CDI, Hackensack-Meridian Health Center
            for Discovery and Innovation, 111 Ideation Way, Nutley, NJ 07110,
            USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 01-SEP-2021
            Assembly Method                   :: Unicycler v. v0.4.9
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100x
            Sequencing Technology :: Oxford Nanopore MiniION and Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/12/2024 03:30:54
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,873
            CDSs (total)                      :: 5,753
            Genes (coding)                    :: 5,579
            CDSs (with protein)               :: 5,579
            Genes (RNA)                       :: 120
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 84
            ncRNAs                            :: 11
            Pseudo Genes (total)              :: 174
            CDSs (without protein)            :: 174
            Pseudo Genes (ambiguous residues) :: 0 of 174
            Pseudo Genes (frameshifted)       :: 70 of 174
            Pseudo Genes (incomplete)         :: 111 of 174
            Pseudo Genes (internal stop)      :: 26 of 174
            Pseudo Genes (multiple problems)  :: 33 of 174
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP088998.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..6796
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="49088"
                     /host="Homo sapiens"
                     /db_xref="taxon:573"
                     /plasmid="p49088-6.796"
     gene            211..387
                     /locus_tag="LRZ82_RS26845"
                     /old_locus_tag="LRZ82_26845"
     CDS             211..387
                     /locus_tag="LRZ82_RS26845"
                     /old_locus_tag="LRZ82_26845"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004197757.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_004197757.1"
                     /translation="MQKPKKKPLVVKKRSWHPAVMANLMRQAQEEDYRREQMAELERSA
                     RSHFADIGGEDGG"
                     /name="hypothetical protein"
     gene            377..721
                     /locus_tag="LRZ82_RS26850"
                     /old_locus_tag="LRZ82_26850"
     CDS             377..721
                     /locus_tag="LRZ82_RS26850"
                     /old_locus_tag="LRZ82_26850"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006122514.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobC family plasmid mobilization relaxosome
                     protein"
                     /protein_id="WP_062955149.1"
                     /translation="MAVKRTRFLGIRVTDGEYQQLLERCNGRQLAVWMRETCLDTRPAR
                     SLRLPSIDPVLLRQLAGMGNNLNQIARKINGGQWSGADRVQVVAALMAIDAELERLRHA
                     VLEKGADDDR"
                     /name="MobC family plasmid mobilization relaxosome protein"
     gene            930..>1364
                     /locus_tag="LRZ82_RS26855"
                     /old_locus_tag="LRZ82_26855"
                     /pseudo=""
     CDS             930..>1364
                     /locus_tag="LRZ82_RS26855"
                     /old_locus_tag="LRZ82_26855"
                     /inference="COORDINATES: protein motif:HMM:NF015397.4"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="relaxase/mobilization nuclease domain-containing
                     protein"
                     /name="relaxase/mobilization nuclease domain-containing
                     protein"
     gene            1399..1908
                     /locus_tag="LRZ82_RS26860"
                     /old_locus_tag="LRZ82_26860"
     CDS             1399..1908
                     /locus_tag="LRZ82_RS26860"
                     /old_locus_tag="LRZ82_26860"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020325392.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MbeB family mobilization protein"
                     /protein_id="WP_032433972.1"
                     /translation="MNSLLTLAKDLEQKSKAQQQSTGEMLKAAFSEHEKSVRAELSESG
                     KRISAAIRAHEQGMSAAMQSNRLSVMRMVGRTWLTITMVSGLLFASLSGVLWYQGSLIA
                     SNLAEIDRQNAALSKLNAKTWGVTYLEDSNGRFLVLPKGTAVDRTQSWTVGNGRSKQNA
                     LRLVKE"
                     /name="MbeB family mobilization protein"
     gene            1915..2127
                     /locus_tag="LRZ82_RS26865"
                     /old_locus_tag="LRZ82_26865"
     CDS             1915..2127
                     /locus_tag="LRZ82_RS26865"
                     /old_locus_tag="LRZ82_26865"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000137423.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MbeD family mobilization/exclusion protein"
                     /protein_id="WP_021527181.1"
                     /translation="MTELEKQLLSALEQLQQDYSKRLDEWESAFGEWRKMSGLMQRENA
                     ALSERVTRLSQQVERLSGQLQRLSR"
                     /name="MbeD family mobilization/exclusion protein"
     gene            2794..3018
                     /locus_tag="LRZ82_RS26870"
                     /old_locus_tag="LRZ82_26870"
     CDS             2794..3018
                     /locus_tag="LRZ82_RS26870"
                     /old_locus_tag="LRZ82_26870"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000879771.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF6290 family protein"
                     /protein_id="WP_000879771.1"
                     /translation="MLAIRLSDEIESRLDSLAKQTGRTKTFYAREAILAHLEDLEDYYL
                     SAETAARVRRGDEAVHSSEDVRKSLGLDD"
                     /name="DUF6290 family protein"
     gene            3002..3268
                     /locus_tag="LRZ82_RS26875"
                     /old_locus_tag="LRZ82_26875"
     CDS             3002..3268
                     /locus_tag="LRZ82_RS26875"
                     /old_locus_tag="LRZ82_26875"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000262326.1"
                     /GO_function="GO:0008657 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) inhibitor activity
                     [Evidence IEA]; GO:0042803 - protein homodimerization
                     activity [Evidence IEA]"
                     /GO_process="GO:0030541 - plasmid partitioning [Evidence
                     IEA]; GO:0051290 - protein heterotetramerization [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_004197762.1"
                     /translation="MVWTINYSDRALKSLRKMDKQNARRIVDFMSLRIAVAADPRQSGK
                     PLKGELGEFWRYRVGDYRVLCEIRDDELVILAATIGHRREVYD"
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            complement(3338..3688)
                     /locus_tag="LRZ82_RS26880"
                     /old_locus_tag="LRZ82_26880"
     CDS             complement(3338..3688)
                     /locus_tag="LRZ82_RS26880"
                     /old_locus_tag="LRZ82_26880"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004197756.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_004197756.1"
                     /translation="MYWLIAFLAFIFPGRSFADGYTAYYRCNGTQEASLTVKDNKLSMV
                     VGLSKFNRQLDTYRFKEKGIEVVMQRAASDDNSEAIMSFIMPDVNNMTLLVKNNGYIIV
                     KTTCWLTKTDKQ"
                     /name="hypothetical protein"
     gene            complement(3754..3942)
                     /locus_tag="LRZ82_RS26885"
                     /old_locus_tag="LRZ82_26885"
     CDS             complement(3754..3942)
                     /locus_tag="LRZ82_RS26885"
                     /old_locus_tag="LRZ82_26885"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_228264513.1"
                     /translation="MSIEESIKETLNSGYMLYRVAPITEGEAAAFMDVLKQLLLFEDNF
                     RLFGRDLVYKIEKLKIR"
                     /name="hypothetical protein"
     gene            complement(3932..4120)
                     /locus_tag="LRZ82_RS29400"
     CDS             complement(3932..4120)
                     /locus_tag="LRZ82_RS29400"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001340235.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_323129225.1"
                     /translation="MGEISVKTGNNARNGGKNSLNRLIRCVCGKKIGPDPRNFNQRVSL
                     GRNDLLIRTFPNIYNEH"
                     /name="hypothetical protein"
     gene            complement(4102..5082)
                     /locus_tag="LRZ82_RS26890"
                     /old_locus_tag="LRZ82_26890"
     CDS             complement(4102..5082)
                     /locus_tag="LRZ82_RS26890"
                     /old_locus_tag="LRZ82_26890"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000019445.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS5-like element ISKpn26 family transposase"
                     /protein_id="WP_000019473.1"
                     /translation="MSHQLTFADSEFSTKRRQTRKEIFLSRMEQILPWQNMVEVIEPFY
                     PKAGNGRRPYPLETMLRIHCMQHWYNLSDGAMEDALYEIASMRLFARLSLDSALPDRTT
                     IMNFRHLLEQHQLARQLFKTINRWLAEAGVMMTQGTLVDATIIEAPSSTKNKEQQRDPE
                     MHQTKKGNQWHFGMKAHIGVDAKSGLTHSLVTTAANEHDLNQLGNLLHGEEQFVSADAG
                     YQGAPQREELAEVDVDWLIAERPGKVKTLKQHPRKNKTAINIEYMKASIRARVEHPFRI
                     IKRQFGFVKARYKGLLKNDNQLAMLFTLANLFRVDQMIRQWERSQ"
                     /name="IS5-like element ISKpn26 family transposase"
     gene            complement(5128..5499)
                     /locus_tag="LRZ82_RS26895"
                     /old_locus_tag="LRZ82_26895"
     CDS             complement(5128..5499)
                     /locus_tag="LRZ82_RS26895"
                     /old_locus_tag="LRZ82_26895"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_228264514.1"
                     /translation="MFFKRYLTEKEIYKAALPIVRLQGRVNTSLRFLSKYSDVNKNGLI
                     ALHLNLLHFISYNIHGVESLKITQAGINKAVQQSPHADEIKNIAQAIGRKGPEYIEGLI
                     RNPWGKKNDNPLRKVRTSS"
                     /name="hypothetical protein"
     gene            complement(5525..5851)
                     /locus_tag="LRZ82_RS26900"
                     /old_locus_tag="LRZ82_26900"
     CDS             complement(5525..5851)
                     /locus_tag="LRZ82_RS26900"
                     /old_locus_tag="LRZ82_26900"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_050516389.1"
                     /translation="MRERTNIMLDIGLKQSLQRLSNKTKMSLSDLINQRLSGSLSVEER
                     IGEKPEWMRNLDPYLANHFSNIELPLPSPLKEYQEKMDEIDSIINDMMVLKEYFRAKFY
                     DEIK"
                     /name="hypothetical protein"
     gene            complement(6209..6367)
                     /locus_tag="LRZ82_RS29405"
     CDS             complement(6209..6367)
                     /locus_tag="LRZ82_RS29405"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005761324.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /protein_id="WP_071596352.1"
                     /translation="MHEPPVQPDCCALSGNYHLESNPDGHAKTPLAAAIGNWIYTREIL
                     RGLEVGA"
                     /name="replication initiation protein"
     Typing          46..125
                     /name="MOBP"
                     /typing="oriT"
                     /tool="MOB-suite"
                     /identity="90.361"
                     /coverage="97.0"
                     /evalue="1.1100000000000001e-21"
     Typing          complement(6259..6656)
                     /name="rep_cluster_2370"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="89.526"
                     /coverage="91.0"
                     /evalue="3.03e-139"
     Typing          712..2243
                     /name="MOBP"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="99.804"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 agccacatat cacacctgcc acatgaggca ctttcatgaa tcgtgctctc atgccaacat
       61 agtaagccag tatacacagc gtaaacgctg tgactggttc agggctgcgc cccgaaaccc
      121 gctaacacca ctgacgcgct ggcgcttgtc caacgccgga gcgacccgga aaacttttcc
      181 gtgccgtccg gcgtttgcga aggagggata atgcagaagc cgaagaagaa gccgctcgtc
      241 gtaaaaaaaa gatcctggca tccggcagtg atggcaaatc tgatgcgtca ggcacaggag
      301 gaagattacc gccgggagca gatggcagag cttgagcgtt cagcccggtc acattttgcg
      361 gatatcggag gagaggatgg cggttaagcg tacccgtttt ttaggtatcc gggtgaccga
      421 tggggagtac cagcagctgc tggagcgctg caatggaagg caactggcgg tgtggatgcg
      481 ggaaacctgt ctcgatacgc gcccggcgcg gtcgttgcgg ctgccgtcca tcgatccggt
      541 tttgctgcgc cagcttgccg ggatggggaa caacctcaac cagatcgccc ggaaaattaa
      601 cggcggccag tggtcaggcg ctgaccgggt tcaggtggtg gccgcgctga tggccattga
      661 tgccgaactc gagcggctgc ggcatgccgt gctggaaaag ggggcagacg atgatcgtta
      721 agtttcatcc gcgagggcga ggcggcggtg ccgggccggt ggattatctg ctggggaaag
      781 accgccagcg cgacggggcc atcgtcctgc agggaaagcc ggaggaggtc cgggagctta
      841 tcgacgcctc gccctacgcc aaaaagtaca cctccggcgt cctgtctttt gctgaacagg
      901 atttaccgcc cggccagcgt gaaaagctga tggcgagctt cgagcgggtt ctgatgcccg
      961 gactcgataa agaccagtac agcgtgctgt gggttgaaca ccgggacaag gggcggctgg
     1021 aactgaattt tctggtaccg aacacggaac tgctgaccgg caggcgtctc cagccgtact
     1081 acgaccgggc agaccgtccg cgcatcgatg cgtggcagac cgtggtgaac gggcgactgg
     1141 ggctgcacga cccgaacgca ccggagaacc ggcgcgcgct ggtgacgcca tcttcgttac
     1201 ccaaaacgaa gcaggaagcc gcagaggcta ttacgcgggg cttactggcc ctcgcctcgt
     1261 caggggagct taaaacgcgt caggacgtca ctgaggcgct ggaaagcgca ggttttgagg
     1321 tcgtgcgcac cacaaagagc agcatcagca ttgccgaccc ggacggaggg cgaaacatcc
     1381 gacttaaggg agccatctat gaacagtctt ttaacgctgg cgaaggactt agagcagaaa
     1441 tcgaaagcgc agcagcagag taccggcgaa atgctgaaag ccgcattcag cgagcacgag
     1501 aagtctgtca gagcggaact gagcgaaagc gggaagagaa tcagcgccgc catccgcgcc
     1561 cacgagcagg gtatgagcgc ggccatgcag tcgaaccgcc tgagcgtgat gcgtatggtc
     1621 gggcggacat ggctgaccat cacgatggtg tcaggactgc tgttcgccag cctgagcggg
     1681 gtgttgtggt atcaggggag cttgatagcg tcaaatctgg ccgaaatcga ccggcagaac
     1741 gcagcgctgt cgaagctgaa cgcgaagacc tggggcgtga cgtacctgga agacagcaac
     1801 ggacgttttc tggtgctgcc gaaggggacg gccgtagaca ggacgcagag ctggacggtc
     1861 gggaacgggc ggtcgaagca gaacgcgctg agactggtga aggagtaagt gccgatgacc
     1921 gagctggaaa aacagttgct gagcgcatta gagcagctac agcaggacta ctcgaaaagg
     1981 ctggacgagt gggagagcgc cttcggggaa tggcggaaaa tgtcagggct tatgcaacgg
     2041 gagaacgcgg cgctgagcga gcgcgtgacg cgcttgagtc agcaggtgga acgcttgagc
     2101 gggcaactgc agcgtttgag ccggtagtgc agcgtcatga gatggccgtg gccgcagaac
     2161 gggcgcacga gcaacggcag cacgaaaagg aactgacgga agcgcgttcc cggcagcgaa
     2221 gctatgacgg tccgtcgctg ggctgaaatg caggaaaaca gggttctcat cgggcattta
     2281 cgctgaaacc ggatgtcatt cacctggctg catggctatg cagccaggta aaatttatct
     2341 gtcgcgaacg gggcggttta tcgggtggtt tgttgccggt tttacctgac tgccaccccg
     2401 ttcgcggcga acccgtccgg ggcggtgcgg gcaacgggtg ttatgtttaa tcagcgtgaa
     2461 cggcagatac aaaaaagccc cggagggctt ttaactactg acttattttt ttgaagattt
     2521 gctgggtttc aatttgtcag tatttcccgg cgttttttta ttgtcacgct ggcgtttatc
     2581 aggttcccct gttgaatcgg caattcgttt cggacccggc ttaagaccca taatcgttat
     2641 cctttcaata gttaagagga aagccctcaa gctagatata ttgaccgcgt tacggattat
     2701 caagaggggc taacaagatt attttttgtt cttttaggtt gattgtggta ctgttgatat
     2761 acatgtatag caaatggtgt tcgggaggtt tatatgcttg ctatccggtt atctgatgag
     2821 attgagtccc gtctggactc gctggcgaag caaaccggca gaacaaagac gttttatgcg
     2881 cgggaagcaa tactggcgca tctggaagac ctggaggatt attatctttc agcagaaact
     2941 gctgcacgcg ttcgccgtgg tgatgaagca gtgcattcgt ctgaagacgt gaggaagtca
     3001 cttggtctgg acgattaact attccgatcg ggcgctcaaa tcgttacgca agatggacaa
     3061 acagaacgca cgacggattg tggattttat gagtttacgc attgcagttg ctgccgatcc
     3121 tcgccagtca gggaagccgc tcaaaggtga gctgggcgag ttctggcgct atcgggtggg
     3181 agattatcgc gttctgtgtg agatccgaga tgacgagctt gttatccttg ccgccacgat
     3241 tggacatcgc cgcgaagttt acgactgaag cccgctatgc gggctttttt gatgccgaca
     3301 acaggtatta tggtaaatac tcgactaact acgtgttcta ctgtttgtcg gttttagtta
     3361 accagcaggt tgtcttaacg ataatgtagc cgttattttt aactaataag gtcatattgt
     3421 taacgtcagg cataataaaa gacattatgg cctcagagtt atcatcagaa gcagctctct
     3481 gcattactac ttcgattccc ttttctttga atctataagt atccagttgc ctattaaact
     3541 tagaaagacc tacaaccata cttagtttgt tatctttaac agtaagagat gcttcctgag
     3601 taccattaca tcggtagtaa gcggtgtaac cgtcagcaaa agatcgaccg gggaatataa
     3661 atgctaggaa cgcaattaac caatacatag ttgagaatct tggtattaca catttcacta
     3721 tcctctcttt catttttcgt tcaccatact ttgttatctg atttttaatt tttctatttt
     3781 ataaaccaag tctctaccaa aaaggcgaaa attatcctca aataataata attgtttaag
     3841 aacatccatg aaagcagctg cttcaccctc agttatggga gctactctat ataacatata
     3901 acctgagtta agggtttctt ttatactttc ttcaatgctc attataaata ttagggaagg
     3961 tgcgaataag caggtcattt cttcccaagc tgactcgctg attaaaattt cgcggatctg
     4021 ggccgatttt tttcccgcaa acacatcgaa tcagcctatt taggctattt tttccaccat
     4081 ttctggcgtt atttccggtt tttactgaga tctctcccac tgacgtatca tttggtccac
     4141 ccgaaacagg ttggccaggg tgaataacat cgccagttgg ttatcgtttt tcagcagccc
     4201 tttgtatctg gctttcacga agccgaactg ccgcttgatg atgcgaaacg ggtgctccac
     4261 cctggcacgg atgctggctt tcatgtattc gatgttgatg gccgttttgt tcttgcgcgg
     4321 atgctgcttc aaggttttta ccttgccggg acgctcggcg atcagccagt ccacatccac
     4381 ctcggccagc tcctcgcgct gtggcgctcc ttggtagccg gcatcggctg agacaaattg
     4441 ctcctctcca tgaagcagat tacccagctg attgaggtca tgctcgttgg ccgcggtggt
     4501 gactaggctg tgggtcaggc cactcttggc atcgacacca atgtgggcct tcatgccaaa
     4561 gtgccactga ttgcctttct tggtctgatg catctccgga tcgcgttgct gctctttgtt
     4621 cttggtagag ctgggtgcct caatgatggt ggcatccacc aaagtgcctt gggtcatcat
     4681 gacgcctgct tcggccagcc agcgattgat ggtcttgaac aattgacggg ccagttgatg
     4741 ctgctcgagc aggtggcgga aattcatgat ggtggtgcga tccggcaggg cgctatccag
     4801 ggataatcgg gcaaacaggc gcatggaggc gatttcgtac agggcatctt ccatggcacc
     4861 gtcgctcagg ttgtaccaat gctgcatgca gtgaatacgc agcatggtct ccagcggata
     4921 gggccgtcgg ccattgcccg ccttgggata aaacggctcg atgacttcca ccatgttttg
     4981 ccatggcaga atctgctcca tgcgggagag gaaaatctct tttcgggtct gacggcgctt
     5041 agtgctgaat tcactatcgg cgaaggtgag ttgatggctc atgatgtccc tctgggatgc
     5101 gctccggatg aatatgatga tctcatatca ggaacttgtt cgcaccttcc ttagtggatt
     5161 atcatttttc ttcccccatg ggtttctaat taatccttcg atgtactcag gtcctttgcg
     5221 tcctattgcc tgcgcaatat tttttatttc atctgcgtga gggctttgtt gtacagcttt
     5281 gtttatgcct gcttgagtga ttttcagaga ctctacaccg tgtatgttgt atgagataaa
     5341 atgtaataaa ttaagatgca atgcaattaa tccatttttg tttacatctg agtatttgga
     5401 taaaaaacgt aatgaagtgt taactctccc ttgaagccta acaattggga gtgctgcctt
     5461 gtatatttcc ttctccgtta aataccgttt aaaaaacata attctccgcc tccgtatagc
     5521 gtgcctattt tatttcgtcg taaaacttag ctctgaaata ttcctttaga accatcatgt
     5581 cattaataat tgaatctatc tcatccattt tttcttggta ttcttttaat ggtgaaggga
     5641 gcggtaactc aatatttgaa aagtgattgg cgagataggg atcaaggttt ctcatccatt
     5701 caggcttttc gccaatgcgt tcttcaactg aaagtgaacc tgataatctc tggttaataa
     5761 gatcacttag actcattttg gttttattcg aaagccgttg taaggattgc tttaatccta
     5821 tatctagcat gatatttgtt ctttctctca ttaccccccc ttgctattgc gttttttgtt
     5881 gcgcacaaag ctaccattgc gcattaagaa acgcaataaa aaaggaggga gggagtggtt
     5941 tgtacatgat gtgcagtgcg ctgagggcat cagtggcggg tgtttttccg tgggatggat
     6001 ggagctccgg ggataacaga actgacgatc atttaaagga tcttcttgag atcctttttt
     6061 tctgcgcgta atctcttgca ctgtaaacga aaaaaccgcc tggggaggcg gtttgatcga
     6121 aggttaagtc agttggggaa ctgcttaacc gggtaactgg gtatacgaga ccgcagatac
     6181 caaaactgtt ctttcagtgt agccgcagtt aggcacccac ttcaagacct ctcaatatct
     6241 ctctcgtata tatccagtta ccaatggctg ctgccagtgg cgtttttgcg tgtccgtccg
     6301 ggttggactc aagatgatag ttaccggaaa gggcgcagca gtcgggctga acggggggtt
     6361 cgtgcataca gcccagcttg gagcgaacga cctaaaccga gccgagatac cagcagcgtg
     6421 agctatgaga aagcgccacg cttcccgaaa gggaaaaagg cggaacaggt atccggtaaa
     6481 cggcagggtc ggaacaggag agcgcacgag ggagccgccg gagagaaatc accggcatct
     6541 ttaagtcctg tcgggtttcg tcctcctctg acttgagcgt ccatttctgt gatgctcgtc
     6601 aggggaggcg gagcctatgg aaaaacggca acgccgcatc cttttctccg gccctttctg
     6661 atttgagcgc ctttgcttta tcccgttatc cgtgagtcgg tcacgcccgc cgcagccgaa
     6721 cggcaggagc gcagctaccg agtgagcgag gaggcgtcat ttcatctgtc cgtgcatggt
     6781 attgcggacg ctcctg
//
