LOCUS       NZ_CP087356            11084 bp    DNA     circular CON 12-SEP-2023
DEFINITION  Acinetobacter baumannii strain DB002 plasmid p2DB002, complete
            sequence.
ACCESSION   NZ_CP087356
VERSION     NZ_CP087356.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN23078444
            Assembly: GCF_024749765.1
KEYWORDS    RefSeq.
SOURCE      Acinetobacter baumannii
  ORGANISM  Acinetobacter baumannii
            Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales;
            Moraxellaceae; Acinetobacter; Acinetobacter calcoaceticus/baumannii
            complex.
REFERENCE   1  (bases 1 to 11084)
  AUTHORS   Mellmann,A.
  TITLE     Sequencing of Acinetobacter baumannii genomes to construct genome
            database for SNP detection
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 11084)
  AUTHORS   Mellmann,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-NOV-2021) Inst. Hygiene, University Hospital Muenster,
            Robert-Koch-Str. 41, Muenster 48149, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 4
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 172x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 09/12/2023 05:28:50
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,069
            CDSs (total)                      :: 3,975
            Genes (coding)                    :: 3,881
            CDSs (with protein)               :: 3,881
            Genes (RNA)                       :: 94
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 94
            CDSs (without protein)            :: 94
            Pseudo Genes (ambiguous residues) :: 0 of 94
            Pseudo Genes (frameshifted)       :: 27 of 94
            Pseudo Genes (incomplete)         :: 61 of 94
            Pseudo Genes (internal stop)      :: 14 of 94
            Pseudo Genes (multiple problems)  :: 7 of 94
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP087356.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..11084
                     /organism="Acinetobacter baumannii"
                     /mol_type="genomic DNA"
                     /strain="DB002"
                     /host="Homo sapiens"
                     /db_xref="taxon:470"
                     /plasmid="p2DB002"
                     /geo_loc_name="Germany"
     gene            join(11075..11084,1..245)
                     /locus_tag="LO000_RS20390"
     CDS             join(11075..11084,1..245)
                     /locus_tag="LO000_RS20390"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001014301.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001014303.1"
                     /translation="MNGQKIDFLRFSKQGNKYFFPCKTKHRPYVTLANFPIQDPAHAGI
                     FLSHTTHLTMTPLKALQDKDFSDFLGSQKRVQKNGLFLE"
                     /name="hypothetical protein"
     gene            517..888
                     /locus_tag="LO000_RS20305"
     CDS             517..888
                     /locus_tag="LO000_RS20305"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000504218.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000504218.1"
                     /translation="MGEKVKTYAVRLDPQVAEFYDQLANSEGIRTSKLFSKILTNDFQS
                     IAVKQQADRIEDLVNRLEKRIDDFEEDNNFSEKYYEDFSGLYFMMLWLLMKNGASKDEV
                     RMIQAKGYSYADDNYKRVK"
                     /name="hypothetical protein"
     gene            888..1061
                     /locus_tag="LO000_RS20310"
     CDS             888..1061
                     /locus_tag="LO000_RS20310"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001282484.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001282484.1"
                     /translation="MSDNIIQLSKPCTLCENRQNVQLFAGLMLCGSCQENIRLTNPSMF
                     SANDEIEQKAQN"
                     /name="hypothetical protein"
     gene            complement(1384..1845)
                     /locus_tag="LO000_RS20315"
     CDS             complement(1384..1845)
                     /locus_tag="LO000_RS20315"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004781077.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DIP1984 family protein"
                     /protein_id="WP_000761346.1"
                     /translation="MKLAEALLLRSDQQKKIISLKQRINANVLVQDGDQPSEDPNELLK
                     QVFSLIQEFQKLSYAIHETNALTKLNDGRSLLALLTLRDEFVEQHKTLTAAISNTSRES
                     DRYSTREIKWHKVIPVSSLQKQADDISLKLRDLNVLIQSTNWKIDLIEA"
                     /name="DIP1984 family protein"
     gene            complement(2150..>3652)
                     /gene="znuD2"
                     /locus_tag="LO000_RS20320"
                     /pseudo=""
     CDS             complement(2150..>3652)
                     /gene="znuD2"
                     /locus_tag="LO000_RS20320"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000932945.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="TonB-dependent receptor ZnuD2"
                     /name="znuD2"
     gene            complement(3825..4817)
                     /locus_tag="LO000_RS20325"
     CDS             complement(3825..4817)
                     /locus_tag="LO000_RS20325"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005028482.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS5-like element ISAba23 family transposase"
                     /protein_id="WP_005028482.1"
                     /translation="MAWKQTGQLSLADSLINAHKAIEELDELHNLIDWQTIEQTLRHVH
                     SSERGESAFHPVIMFKVLLLQKLYNLSDPAMEKQLARDLLFRRFVGLSLTDDVPDHSTI
                     WRYHKHLGELRLIEPLFNQINEQLAQQNIFIKAGSVSIIDASIVEAKNKRPKKGKHTDN
                     TQDNEAAYVSKKDSTGKVKTTYGFKIHLNCDEDSFVKKVETTPANVHDSQCFTTLLTDD
                     ESAVYADSAYKSQAHDDYLAEHEPPIKNHIHDRAWRNTPLTEQQKRNNTQKSQTRNTVE
                     RVFGHFKLHYGMSKARHLGLMQFHTSTLLASMVHNLKTALSLKRKYGLA"
                     /name="IS5-like element ISAba23 family transposase"
     gene            complement(<4901..5815)
                     /gene="znuD2"
                     /locus_tag="LO000_RS20330"
                     /pseudo=""
     CDS             complement(<4901..5815)
                     /gene="znuD2"
                     /locus_tag="LO000_RS20330"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000932945.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="TonB-dependent receptor ZnuD2"
                     /name="znuD2"
     gene            complement(5943..6257)
                     /locus_tag="LO000_RS20335"
     CDS             complement(5943..6257)
                     /locus_tag="LO000_RS20335"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006582675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BrnA antitoxin family protein"
                     /protein_id="WP_001983304.1"
                     /translation="MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEI
                     TDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQGKGYQTRMNEILRDAMLKELKNHQ
                     "
                     /name="BrnA antitoxin family protein"
     gene            complement(6244..6531)
                     /locus_tag="LO000_RS20340"
     CDS             complement(6244..6531)
                     /locus_tag="LO000_RS20340"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019383542.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BrnT family toxin"
                     /protein_id="WP_000438826.1"
                     /translation="MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNG
                     EERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIISARQVTKAERNKYEHG"
                     /name="BrnT family toxin"
     gene            complement(6802..7548)
                     /locus_tag="LO000_RS20345"
     CDS             complement(6802..7548)
                     /locus_tag="LO000_RS20345"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005262957.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS5-like element ISAba31 family transposase"
                     /protein_id="WP_005262957.1"
                     /translation="MPRTMLTDQHWQKLKVILRNLSIHHNSNLRNFIEAILYRIRTGCP
                     WRDIPSCFGHSNSIFKRFNRWSSSGKLLRLFKLLASCPDMEWIFIDGSHVRAHQHSAGI
                     ANQSISKSVGGNSSKIHLIVDAHGNPIDFMITDGTTHDVKVAPDLISTLDLKETKVVCA
                     DKGYDSEPLREQIRKTGTKANIPKKTNSQSNNDHMDWYLYKIRHLVENMFCRLKQFRGI
                     ATRYDKLKRNYQSSVALACIFLWLPL"
                     /name="IS5-like element ISAba31 family transposase"
     gene            7700..8527
                     /locus_tag="LO000_RS20350"
     CDS             7700..8527
                     /locus_tag="LO000_RS20350"
                     /EC_number="3.5.2.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_057689930.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="OXA-24 family carbapenem-hydrolyzing class D
                     beta-lactamase OXA-72"
                     /protein_id="WP_000713530.1"
                     /translation="MKKFILPIFSISILVSLSACSSIKTKSEDNFHISSQQHEKAIKSY
                     FDEAQTQGVIIIKEGKNLSTYGNALARANKEYVPASTFKMLNALIGLENHKATTNEIFK
                     WDGKKRTYPMWEKDMTLGEAMALSAVPVYQELARRTGLELMQKEVKRVNFGNTNIGTQV
                     DNFWLVGPLKITPVQEVNFADDLAHNRLPFKLETQEEVKKMLLIKEVNGSKIYAKSGWG
                     MDVTPQVGWLTGWVEQANGKKIPFSLNLEMKEGMSGSIRNEITYKSLENLGII"
                     /name="OXA-24 family carbapenem-hydrolyzing class D
                     beta-lactamase OXA-72"
     gene            complement(8710..8853)
                     /locus_tag="LO000_RS20355"
     CDS             complement(8710..8853)
                     /locus_tag="LO000_RS20355"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004786602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001125246.1"
                     /translation="MPKLKDIALGIIVAPLLIPIMLIASYQDKKALKKELDECQKEKDQ
                     AS"
                     /name="hypothetical protein"
     gene            complement(8873..9448)
                     /locus_tag="LO000_RS20360"
     CDS             complement(8873..9448)
                     /locus_tag="LO000_RS20360"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005102333.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid replication DNA-binding protein"
                     /protein_id="WP_001096616.1"
                     /translation="MAKLSLSEVSKKFHVDRSTIYRAVRNGRLSRSSDGQFDLAEVIRC
                     FGEPEQTSQKIESSKQEGDESTKKLIAHLENEVKKYQEREERLMQQIDRMQTLIELKSV
                     APATAAPHQDATACDTKMPQHATTQQDTDNKKNNELNIAENVAVPQQETTAYHTQTLQH
                     ATLQSVAVPQHKKRGLFGRVLNAVFDND"
                     /name="plasmid replication DNA-binding protein"
     gene            complement(9441..10391)
                     /gene="repM"
                     /locus_tag="LO000_RS20365"
     CDS             complement(9441..10391)
                     /gene="repM"
                     /locus_tag="LO000_RS20365"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004786597.1"
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006270 - DNA replication initiation
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein RepM"
                     /protein_id="WP_001205343.1"
                     /translation="MRDLVVKDNALINASYNLDLVEQRLILLAIVEARESGKGINANDP
                     LEVHADSYINQFGVHRNTAYQALKDACKDLFARQFSYQEKKANGNIRNVMSRWVSQIAY
                     NDNEATVDLIFAPAVVPFITRLEEQFTKYELQQVSSLSSAYAIRLYELLIQWRSTGKTP
                     TIELQEFRKKLGVLDNEYLRMAHLKERVLELSIKQINEHTDITVKYEQHKRGRSISGFS
                     FTFKQKKKDSPSIERDPNTLELFSKMTDAQRHMFANKLSELPEMGRYSQGTESYQQFAV
                     RIAEMLQDPAQFKELYPYLKKVGYMPSNKKDTVNG"
                     /name="repM"
     ARG             7701..8524
                     /name="blaOXA-72"
                     /gene="blaOXA-72"
                     /gene_name="OXA-24 family carbapenem-hydrolyzing class D
                     beta-lactamase OXA-72"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     Typing          complement(9442..10391)
                     /name="rep_cluster_1172"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 aaaaaattga ttttttacgt ttttctaaac aaggaaataa atactttttt ccatgcaaaa
       61 ccaagcaccg gccctacgtc actttagcca attttccaat ccaagatccg gcacatgccg
      121 ggattttttt gtcacacacc acgcatctaa cgatgacacc cctcaaagcc ttacaggata
      181 aggatttcag cgatttttta gggtctcaga aacgtgtaca gaaaaatggt ctttttttag
      241 aataagtgat tgaattatct attttttatg ctgtgctcat ggttgtacat caaaacaaca
      301 ctttttttag ataagatatt gataaattta agaaaaaata tgtactcatg attgtacata
      361 aaaaaagcat tatatttaaa taagtttttg ttttagaata aattaattct gtacaaataa
      421 gtttgtacgt aatctaatta ttatttttta tttaattagt tgaattatat atatttaatt
      481 ttgtacaaaa tctaatttta ataagaggtg taatttatgg gcgaaaaagt caaaacttat
      541 gcagtcaggt tagatccaca agtagcagaa ttctacgatc aattggctaa ttcagaagga
      601 atcagaacca gtaaattatt cagtaaaatt ttgaccaatg attttcaatc tattgctgtt
      661 aaacagcaag ccgatcgtat tgaggatctg gtgaatcgat tagaaaagcg aatagatgat
      721 tttgaggaag ataacaattt ttctgaaaaa tactatgaag acttttctgg actatatttc
      781 atgatgttgt ggctcttaat gaaaaatggc gcttctaaag atgaggttag aatgatacaa
      841 gctaaaggtt attcatatgc agatgataac tataagaggg taaagtagtg tcagataata
      901 ttattcagct ttcaaagcca tgtacgcttt gtgaaaatag acaaaatgta caactttttg
      961 caggattgat gctgtgtgga agttgtcagg aaaatatcag gcttacgaat ccaagtatgt
     1021 tctcggccaa tgatgagatt gaacaaaaag cccagaatta acctgggctt cgtataagag
     1081 attttatgtt aaatgccgaa ctgaattaaa aatagaaatg tagttgagct gatgcttgtt
     1141 catttcttta tttttagtaa ttgaggtgaa catactgtca gtacatggta gttataagta
     1201 acgtgtaact ttgtttgcac aaagatttga gttatgccaa gtgatggatt gatttgtact
     1261 taaaatttta agcttatcca cttgctttgc aagccactac actttattta caatcctatg
     1321 ttgtggaagt aagggatctt gtactcgccc agtatgttca acttgattat atctaaagga
     1381 ctattaggct tcaatcaaat caattttcca attagtcgac tgaattaaca cgtttaaatc
     1441 acgtaattta agactaatat catcagcttg tttttgtaat gatgaaactg gaataacttt
     1501 atgccacttt atttcccgcg tactataacg atcagattca cgagatgtat tacttattgc
     1561 tgcagttagg gttttgtgct gttctacaaa ttcatcacgc aaagtcaata aagcaagtag
     1621 agaacggcca tcatttaatt ttgttaaagc attagtttca tgaattgcat aacttaattt
     1681 ttgaaattct tgaattaaag aaaatacttg ttttagtagt tcatttggat cttcagatgg
     1741 ttgatcacca tcttgtacca atacatttgc attgatacgt tgttttagtg aaataatttt
     1801 tttttgttga tcacttcgaa gtaagagagc ttctgctaat ttcatttttc acctattaac
     1861 caattagaat taagttttaa acagcttata tcctcattct ttaaagatca aaaaaattgc
     1921 tttttatcta gctaaaaggt gtctacaaaa tcggtggcta ttcagtgctg aaaaggctgc
     1981 cgacacataa agtgacccag attgaagagt tactgccaca ctgctggaaa cctaaatcga
     2041 attaaaaaat aggtatggga ttcagcggac gcttacctta attattaatc taatcatttt
     2101 ataagaaaaa tcttctaaga aattttctta gaagattaca gtatcttatc tagaaattaa
     2161 gatttaagcc taaactaaaa tttcttccaa tttggggaat atatggcaaa aatgtttcat
     2221 gggcatagac tttctgatca agtaaattat tcgctttaaa gaataaatca tattctgtgt
     2281 gagatagctt atttttatat gctaaagtca tattaagcat attataacct gatgtaacct
     2341 gctcaaattt agaaatatta tcttgtttaa agactcgata atattctatt tcacctttaa
     2401 gcgattcatc aaaatcagct tttagtcgtg tacccaaacg agcaggaggt aatctaggag
     2461 tgtaacgatc cttttgggga gctaaagtcg gttctctatt ccagatatcg tatgcaatta
     2521 cagcatcagg taaatttgtt aaacggcctt tcacataatc tccaaaaaga gagccgtgat
     2581 aaacagaatt aaattgatac cctatgttgc cctctaatcc ataaaaatta gcagcagact
     2641 ggctataatg attaatacgt agtgtatgct gatctctaac ttttgtagtt cctaaaactt
     2701 cattgagtgt ctgtaaatat atatagttat caaaatcata atagtaagta ctgatttgat
     2761 aatcaagtaa atcatcctta taggccagac tgatttctaa attattggat ttctcttttc
     2821 ttagaaagcg gttacctatt tcaaaagaat tagtagcgag atgcatacca tgagtataca
     2881 tttcttgtgc attaggtaat ctttcttgat gtgtacctgt taatgataag atataatttg
     2941 gagcaaatct ccagtggact gtacctgcat aagaaaaagc tgtttctttg ttaggttgaa
     3001 cagcttctaa aatagatttt aaattttgag ccctgatttt attatttttt tctacataag
     3061 gactgttata tttattaggc caaggtttca ttgaatcttt aattttttct atatcataat
     3121 ccatactaac tttctgcttt tctatacgag cacctagttc gaaagtaaag tcgttccagt
     3181 tatatttttc taggccaaat acactaaagt ttttagtgac atttcgattt aatagctgct
     3241 gattatctag ataggtggta tggccttctt gagaatggac tggtgataaa gcactattat
     3301 cctgttccaa atattgtagc cccaagatac cggttaattc ccctaatggc tgatgtgata
     3361 actctatgcg gcctactttt cctgtatttt taaaaaagtt agtaatctta tctccctcga
     3421 gttcattgtg aaaataatct atataactca atgaggtacg aattttgtca ataccggtaa
     3481 atggttgagt gaattctcca cgcacatcat aacgtcgagt atttaaatca atataaggag
     3541 cattatgaga gaaattagtt tcatgaatat gattatgctg atgacaatca ggacgtggat
     3601 ttatgtaatt aatatcttgc tcatccatca attgaggata atataaaaga tagagacctt
     3661 tgcacgaaac agcccctttg ctcgaggcat accaccaaac cgaaaaaaaa caaagaatgg
     3721 caatgaaata agcaaaacaa tggctaaatc atggataaaa tctccaaatg gttgttaaat
     3781 ttgtgtctat tggctgagct tactaaccaa caggcacaat aaccctaggc gagtccgtat
     3841 tttcgtttca agcttagggc agtttttaaa ttatgcacca tgcttgcaag caaagtgctg
     3901 gtatgaaatt gcattaaccc taaatgacga gctttgctca tcccataatg cagtttaaaa
     3961 tgtccaaaga cccgctcaac ggtgtttcta gtttggctct tttgggtatt attgcgtttt
     4021 tgctgttcgg ttaagggtgt attgcgccat gctctatcat gaatatgatt ttttatcggt
     4081 ggttcatgct cggcaaggta gtcatcatgg gcttggcttt tatacgcact gtcagcatac
     4141 acggctgatt catcatctgt taacagcgtg gtaaaacatt gggaatcatg gacattggca
     4201 ggggtagttt caaccttttt gacaaagctg tcttcatcac agttgagatg aattttaaag
     4261 ccgtaggtgg tttttacttt acctgtactg tcttttttac tgacataggc ggcttcgtta
     4321 tcttgggtat tgtcggtgtg tttgcctttc ttaggtcgtt tgtttttagc ttcaacgata
     4381 ctggcatcga tgatgctgac actgcccgct ttgataaaaa tgttttgttg ggctagttgc
     4441 tcattgattt ggttgaacaa tggttcaatc agtctaagct cacctaggtg tttgtggtat
     4501 cgccaaatgg tgctatggtc gggtacatca tccgttaatg ataggccaac aaagcgacga
     4561 aatagtaagt ctcgtgccag ttgtttttcc atggctggat ccgataggtt atagagtttt
     4621 tgtaagagta atactttaaa catgatgaca gggtgaaagg cagattcccc acgctcactg
     4681 ctatgaacgt ggcgtaaggt ttgctcgata gtttgccagt caattaggtt gtgtagttca
     4741 tctaattctt cgatggcttt gtgagcgtta atgagactgt ctgctaggga gagttgccct
     4801 gtttgtttcc atgccatagt cgtgtctttt gctaggtgat tgattttatt gtattatacc
     4861 aatttaatgg acttttgtgt gtttattcgt gcaaaggttt cagataattt tttaatccac
     4921 taattcgtga atcgataccg attgcagagg caccacaacc ttcatataaa tggctatggg
     4981 ctggtaaacc atattcatca tgacgatgtg tataagaaac tcctaaataa gtattatcgt
     5041 ctatccagga taatccaagc gtacctactc tcgactctgc ccagctttct ggtaaatatt
     5101 ttaaattttt ataaatactg ttttggtttt caagatcttc taaagaatta taagagctag
     5161 actggtaatg aggagtttta tagttaccag cattacgata taacccttct gcccgtaaag
     5221 ctacatgtgg gcttaagcca actgttacac ctgctgtggt caacttctca ttactgccag
     5281 tattaaaacg taatgtagta ttaccctcta atccgtcttg aggcatttgg gttggaattt
     5341 tatagtcaat gacattgact acccctgccg cactatttga actatacaaa agggtacttg
     5401 caccacgtat aatttcaata gacttagcta aacttggttc aactgtgaca gcgtgatctg
     5461 gggacatatt agacatatcc aacacgtcag cattattctg taaaacttta atacgttttc
     5521 cttcctgccc acgaataata ggagtagatg ctccacctcc atattgatta gaatgaattc
     5581 ctaattccgt acccaaggca tcccctagag ttgtcgaacg ctgtttaagt ttactagtat
     5641 caataaactg attactaaca tttagacttt tgcctaacag ctcagaccct aactcatcag
     5701 attgtgcagt taatactatt gtatttaagg tagtaacagg cccttcagct gccaataaaa
     5761 ttttcgaggc ccctaaagta attaaagcta aaaatagttt acttttattt agcataaaac
     5821 aaccaaattt aatgttatat tataatataa cacttaaaaa tttataaaat ctactattta
     5881 aatttttgaa tggtaatccc ccctaaaaat gaagtcaaaa atgggagcct aagctcccat
     5941 tcttattgat gattttttaa ttcttttagc atagcatctc gtaaaatttc attcatacgt
     6001 gtttgataac ctttgccttg tgctttgaac caagcaagta catcagcatc taaccgaatt
     6061 gaagtttgtt gctttactgg gcggtaaaat tgattttggc gtacagcatt gctccagtct
     6121 gtaatttcag gaatatctga tagatctagc tgatcatcag gaaccgtgcc tttagcaagc
     6181 aagcgttgaa tttcagcatc ttgcttctca ccaaatttct cattcagctc tttgtgtgag
     6241 tatctaacca tgctcatatt tgtttcgctc cgctttagtg acttgccttg cactaatgat
     6301 tcggatgatt tcacagtcat cttcatcaaa aatggtgtga gccaccaata acattagtac
     6361 gcctttaact cgtccaatgg tttgccaacg ttcttcacca ttggtatgtc tgtcttggat
     6421 tgagatccgt aatggatctt caaaaacaag gcttgcagtt tcgaaagaga tatcatgctt
     6481 tttctgattc tttcgattct tagcctcatc ccattcaaaa tactgttcca taaaaaacat
     6541 tcaaatttgt atatacaata atgtatcaca aaattgtatc actcaaccag attcgtgtaa
     6601 tttttagtca aaattattgg caagaagtat caaaactgct cataaaaaag ccgacttgtt
     6661 tcaaagtcgg ctttttgggc attttgggat ttttctattt ttattaagta gttgatattt
     6721 atattaatat acaagtgtac ttcgtataat cgccattatg ttaaattagg gtctgttgac
     6781 acttactgtt cataattaac cctataaagg tagccataaa aatatacagg ctaaggcaac
     6841 agaactttga taatttcttt tgagcttgtc atatcgagta gctattcctc taaattgctt
     6901 taatctacaa aacatatttt caactaaatg cctgatttta tataaatacc agtccatatg
     6961 gtcattgttc gattggctat tcgttttctt tggtatattc gctttagtcc ctgttttcct
     7021 gatctgttca cgcagtggtt ctgaatcata gcctttatct gcgcatacca cttttgtctc
     7081 ttttaaatct aatgttgata ttaaatcagg cgcaacttta acatcatgtg tggttccatc
     7141 ggtaatcatg aaatcaatag gattgccatg tgcatcaaca atcaaatgta tttttgagga
     7201 gtttcctcct acacttttag aaatagattg attcgctatg ccggcagaat gttgatgagc
     7261 acgtacatga gagccatcaa taaaaatcca ctccatatcg gggcatgagg ctagtaattt
     7321 gaataatcta agtaacttac cgctgcttga ccaacgatta aaacgtttga aaatagagtt
     7381 ggaatgacca aaacaagaag gaatatctcg ccacggacag cctgttctaa ttctatagag
     7441 aatagcttca ataaaattgc gtaaatttga gttgtggtga atggataaat tacgcagaat
     7501 aactttcaac ttttgccagt gttgatctgt cagcatggta cgaggcatag cgaatagtaa
     7561 aattgggttt ggtgatttga ttttactact tcgctatttt tttaagctaa aagtgtcaac
     7621 acaccctaaa agagttttaa cttttttaat aaaaatatta tactctaagc cccaaaattt
     7681 cccctaacat gaatttgtaa tgaaaaaatt tatacttcct atattcagca tttctattct
     7741 agtttctctc agtgcatgtt catctattaa aactaaatct gaagataatt ttcatatttc
     7801 ttctcagcaa catgaaaaag ctattaaaag ctattttgat gaagctcaaa cacagggtgt
     7861 aattattatt aaagagggta aaaatcttag cacctatggt aatgctcttg cacgagcaaa
     7921 taaagaatat gtccctgcat caacatttaa gatgctaaat gctttaatcg ggctagaaaa
     7981 tcataaagca acaacaaatg agattttcaa atgggatggt aaaaaaagaa cttatcctat
     8041 gtgggagaaa gatatgactt taggtgaggc aatggcattg tcagcagttc cagtatatca
     8101 agagcttgca agacggactg gcctagagct aatgcagaaa gaagtaaagc gggttaattt
     8161 tggaaataca aatattggaa cacaggtcga taatttttgg ttagttggcc cccttaaaat
     8221 tacaccagta caagaagtta attttgccga tgaccttgca cataaccgat taccttttaa
     8281 attagaaact caagaagaag ttaaaaaaat gcttctaatt aaagaagtaa atggtagtaa
     8341 gatttatgca aaaagtggat ggggaatgga tgttactcca caggtaggtt ggttgactgg
     8401 ttgggtggag caagctaatg gaaaaaaaat ccccttttcg ctcaacttag aaatgaaaga
     8461 aggaatgtct ggttctattc gtaatgaaat tacttataag tcgctagaaa atcttggaat
     8521 catttaataa tttctaaaat taacataata cgccttatac gaaatgctgt ataattatcc
     8581 ttataattca acgctgtagt ttctagttta tagcccgagc atccctgttc gggctttttt
     8641 tatgactttt cacgttccac gctattattt catcaatgtt ccacactttt gattagctca
     8701 attgaataat caggatgcct ggtctttttc tttttggcat tcatccagct ctttcttcag
     8761 cgccttttta tcctggtacg atgcaatcag catgatcggg atcagcagcg gagctacaat
     8821 aattcccagg gcaatgtctt tcagtttcgg catgatcttt cacccttatt gctcagtcat
     8881 tatcaaagac ggcattcagc acacggccaa ataaaccacg ttttttgtgt tgtggcactg
     8941 ccacactttg caacgtggca tgctgtagcg tttgggtgtg gtatgccgta gtttcttgct
     9001 gtggcactgc tacattttct gcaatattta attcattatt ctttttgtta tcagtgtctt
     9061 gttgtgttgt cgcatgctgt ggcatcttgg tgtcgcatgc cgtagcatct tggtgtggtg
     9121 ctgctgtggc aggtgcaaca cttttcagct caatgagtgt ttgcatacgg tcaatttgtt
     9181 gcattaaccg ttcttcacgt tcttggtatt ttttgacttc attttctaaa tgggcaataa
     9241 gtttttttgt agattcatca ccttcttgct tagatgattc aattttttga gatgtttgct
     9301 caggttctcc aaagcatcgt atgacctctg ctagatcgaa ttgtccatca ctggagcgtg
     9361 ataaacgtcc attacgtaca gctctgtaaa tggttgatct atccacatga aattttttag
     9421 atacttcact tagtgataac ttagccattt acggtgtcct ttttatttga tggcatgtat
     9481 cccacttttt ttaggtatgg gtatagctct ttgaattgag cgggatcttg tagcatctca
     9541 gcaatacgta cagcaaactg ttggtagctt tctgttcctt gtgaatagcg acccatttca
     9601 gggagttctg aaagtttatt tgcaaacata tgccgttgag catcggtcat ctttgaaaaa
     9661 agctccaaag tgttcggatc tctttctatt gatgggctat ccttcttctt ctgtttaaag
     9721 gtaaaagaaa atcctgaaat agaacgtcct cttttatgct gttcatattt tacagttata
     9781 tccgtatgct catttatttg tttaattgaa agctctaaaa cacgctcttt taaatgagcc
     9841 atccgtaaat attcattatc aagaacgcct aacttctttc taaattcttg tagttctatg
     9901 gttggggttt taccagtgct tcgccactga attagaagct catataagcg aatggcataa
     9961 gcgctactaa gactactaac ttgctgtaat tcatatttag taaattgttc ttccagtcgg
    10021 gttatgaagg gaacaacagc aggtgcaaat attaagtcta cagttgcttc attgtcgtta
    10081 taagcaattt gagataccca acgactcata acatttcgga tattcccatt agcttttttc
    10141 tcttgatagc taaattgacg cgcgaataaa tccttacaag catcttttaa ggcttgataa
    10201 gctgtattac ggtgtacacc aaattgattg atataactat ctgcatgaac ttctaatgga
    10261 tcatttgcat taatcccttt cccactttcc cttgcttcaa caatagccaa taaaattaaa
    10321 cgttgttcta ctaagtctaa gttatagctt gcgttgatta aggcattgtc ctttacaact
    10381 aaatctctca tagccactat tttttattgt gtataagtac acgttaatat tatttgtgta
    10441 ctaatgcaag gtaaacgtgg acatattgca aggtaaacgt ggacatattg caaggtaaac
    10501 gtggacatat tgcaaggtaa acgtggacat ataagagcta aaacccttta ttcataaggc
    10561 tttcaagcca tttaaaagta tttaaaaact ttaaaataat taaaagccca gggaatgaaa
    10621 aattgccctt ggttttcgct tcgctcaaac tctattgaac ttcgctttcg ctcagttcgt
    10681 tggggcaatt ttttggttaa tactggcgtg actttaaaaa aaagcaaaag aaacttggaa
    10741 ttcgcttcgc tcataaaact tttttactcg ctacgctcga tccaggagca aatttctgca
    10801 cgaaacttac gctttcttag gctaaagagg acaaaaaaat gtttttcaga gggtctaggc
    10861 gcaaattttg atagttcgct cgtagacact cgctctatgc atctatctaa agtcaaaata
    10921 cctctttatt tcgctctcat ttgcgttttt tgagctgttt tgtgtttttc actatgagat
    10981 ctatgttttc taggtaaagg ctcttaaatc gcatttgaac gcgttctatg aagcttttca
    11041 taattaaagt tttgggttga aatttttaac ctggatgaat ggac
//
