LOCUS       NZ_CP087346            11084 bp    DNA     circular CON 12-SEP-2023
DEFINITION  Acinetobacter baumannii strain DB007 plasmid p2DB007, complete
            sequence.
ACCESSION   NZ_CP087346
VERSION     NZ_CP087346.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN23078449
            Assembly: GCF_024749665.1
KEYWORDS    RefSeq.
SOURCE      Acinetobacter baumannii
  ORGANISM  Acinetobacter baumannii
            Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales;
            Moraxellaceae; Acinetobacter; Acinetobacter calcoaceticus/baumannii
            complex.
REFERENCE   1  (bases 1 to 11084)
  AUTHORS   Mellmann,A.
  TITLE     Sequencing of Acinetobacter baumannii genomes to construct genome
            database for SNP detection
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 11084)
  AUTHORS   Mellmann,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-NOV-2021) Inst. Hygiene, University Hospital Muenster,
            Robert-Koch-Str. 41, Muenster 48149, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 4
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 147x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 09/12/2023 05:22:39
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,128
            CDSs (total)                      :: 4,030
            Genes (coding)                    :: 3,924
            CDSs (with protein)               :: 3,924
            Genes (RNA)                       :: 98
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 106
            CDSs (without protein)            :: 106
            Pseudo Genes (ambiguous residues) :: 0 of 106
            Pseudo Genes (frameshifted)       :: 39 of 106
            Pseudo Genes (incomplete)         :: 61 of 106
            Pseudo Genes (internal stop)      :: 14 of 106
            Pseudo Genes (multiple problems)  :: 7 of 106
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP087346.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..11084
                     /organism="Acinetobacter baumannii"
                     /mol_type="genomic DNA"
                     /strain="DB007"
                     /host="Homo sapiens"
                     /db_xref="taxon:470"
                     /plasmid="p2DB007"
                     /geo_loc_name="Germany"
     gene            49..795
                     /locus_tag="LOZ99_RS20585"
     CDS             49..795
                     /locus_tag="LOZ99_RS20585"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005262957.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS5-like element ISAba31 family transposase"
                     /protein_id="WP_005262957.1"
                     /translation="MPRTMLTDQHWQKLKVILRNLSIHHNSNLRNFIEAILYRIRTGCP
                     WRDIPSCFGHSNSIFKRFNRWSSSGKLLRLFKLLASCPDMEWIFIDGSHVRAHQHSAGI
                     ANQSISKSVGGNSSKIHLIVDAHGNPIDFMITDGTTHDVKVAPDLISTLDLKETKVVCA
                     DKGYDSEPLREQIRKTGTKANIPKKTNSQSNNDHMDWYLYKIRHLVENMFCRLKQFRGI
                     ATRYDKLKRNYQSSVALACIFLWLPL"
                     /name="IS5-like element ISAba31 family transposase"
     gene            1066..1353
                     /locus_tag="LOZ99_RS20590"
     CDS             1066..1353
                     /locus_tag="LOZ99_RS20590"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019383542.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BrnT family toxin"
                     /protein_id="WP_000438826.1"
                     /translation="MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNG
                     EERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIISARQVTKAERNKYEHG"
                     /name="BrnT family toxin"
     gene            1340..1654
                     /locus_tag="LOZ99_RS20595"
     CDS             1340..1654
                     /locus_tag="LOZ99_RS20595"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006582675.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="BrnA antitoxin family protein"
                     /protein_id="WP_001983304.1"
                     /translation="MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEI
                     TDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQGKGYQTRMNEILRDAMLKELKNHQ
                     "
                     /name="BrnA antitoxin family protein"
     gene            1782..>2696
                     /gene="znuD2"
                     /locus_tag="LOZ99_RS20600"
                     /pseudo=""
     CDS             1782..>2696
                     /gene="znuD2"
                     /locus_tag="LOZ99_RS20600"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000932945.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="TonB-dependent receptor ZnuD2"
                     /name="znuD2"
     gene            2780..3772
                     /locus_tag="LOZ99_RS20605"
     CDS             2780..3772
                     /locus_tag="LOZ99_RS20605"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005028482.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS5-like element ISAba23 family transposase"
                     /protein_id="WP_005028482.1"
                     /translation="MAWKQTGQLSLADSLINAHKAIEELDELHNLIDWQTIEQTLRHVH
                     SSERGESAFHPVIMFKVLLLQKLYNLSDPAMEKQLARDLLFRRFVGLSLTDDVPDHSTI
                     WRYHKHLGELRLIEPLFNQINEQLAQQNIFIKAGSVSIIDASIVEAKNKRPKKGKHTDN
                     TQDNEAAYVSKKDSTGKVKTTYGFKIHLNCDEDSFVKKVETTPANVHDSQCFTTLLTDD
                     ESAVYADSAYKSQAHDDYLAEHEPPIKNHIHDRAWRNTPLTEQQKRNNTQKSQTRNTVE
                     RVFGHFKLHYGMSKARHLGLMQFHTSTLLASMVHNLKTALSLKRKYGLA"
                     /name="IS5-like element ISAba23 family transposase"
     gene            <3945..5447
                     /gene="znuD2"
                     /locus_tag="LOZ99_RS20610"
                     /pseudo=""
     CDS             <3945..5447
                     /gene="znuD2"
                     /locus_tag="LOZ99_RS20610"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000932945.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="TonB-dependent receptor ZnuD2"
                     /name="znuD2"
     gene            5752..6213
                     /locus_tag="LOZ99_RS20615"
     CDS             5752..6213
                     /locus_tag="LOZ99_RS20615"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004781077.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DIP1984 family protein"
                     /protein_id="WP_000761346.1"
                     /translation="MKLAEALLLRSDQQKKIISLKQRINANVLVQDGDQPSEDPNELLK
                     QVFSLIQEFQKLSYAIHETNALTKLNDGRSLLALLTLRDEFVEQHKTLTAAISNTSRES
                     DRYSTREIKWHKVIPVSSLQKQADDISLKLRDLNVLIQSTNWKIDLIEA"
                     /name="DIP1984 family protein"
     gene            complement(6536..6709)
                     /locus_tag="LOZ99_RS20620"
     CDS             complement(6536..6709)
                     /locus_tag="LOZ99_RS20620"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001282484.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001282484.1"
                     /translation="MSDNIIQLSKPCTLCENRQNVQLFAGLMLCGSCQENIRLTNPSMF
                     SANDEIEQKAQN"
                     /name="hypothetical protein"
     gene            complement(6709..7080)
                     /locus_tag="LOZ99_RS20625"
     CDS             complement(6709..7080)
                     /locus_tag="LOZ99_RS20625"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000504218.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000504218.1"
                     /translation="MGEKVKTYAVRLDPQVAEFYDQLANSEGIRTSKLFSKILTNDFQS
                     IAVKQQADRIEDLVNRLEKRIDDFEEDNNFSEKYYEDFSGLYFMMLWLLMKNGASKDEV
                     RMIQAKGYSYADDNYKRVK"
                     /name="hypothetical protein"
     gene            complement(7352..7606)
                     /locus_tag="LOZ99_RS20695"
     CDS             complement(7352..7606)
                     /locus_tag="LOZ99_RS20695"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001014301.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001014303.1"
                     /translation="MNGQKIDFLRFSKQGNKYFFPCKTKHRPYVTLANFPIQDPAHAGI
                     FLSHTTHLTMTPLKALQDKDFSDFLGSQKRVQKNGLFLE"
                     /name="hypothetical protein"
     gene            8290..9240
                     /gene="repM"
                     /locus_tag="LOZ99_RS20630"
     CDS             8290..9240
                     /gene="repM"
                     /locus_tag="LOZ99_RS20630"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004786597.1"
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006270 - DNA replication initiation
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein RepM"
                     /protein_id="WP_001205343.1"
                     /translation="MRDLVVKDNALINASYNLDLVEQRLILLAIVEARESGKGINANDP
                     LEVHADSYINQFGVHRNTAYQALKDACKDLFARQFSYQEKKANGNIRNVMSRWVSQIAY
                     NDNEATVDLIFAPAVVPFITRLEEQFTKYELQQVSSLSSAYAIRLYELLIQWRSTGKTP
                     TIELQEFRKKLGVLDNEYLRMAHLKERVLELSIKQINEHTDITVKYEQHKRGRSISGFS
                     FTFKQKKKDSPSIERDPNTLELFSKMTDAQRHMFANKLSELPEMGRYSQGTESYQQFAV
                     RIAEMLQDPAQFKELYPYLKKVGYMPSNKKDTVNG"
                     /name="repM"
     gene            9233..9808
                     /locus_tag="LOZ99_RS20635"
     CDS             9233..9808
                     /locus_tag="LOZ99_RS20635"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005102333.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid replication DNA-binding protein"
                     /protein_id="WP_001096616.1"
                     /translation="MAKLSLSEVSKKFHVDRSTIYRAVRNGRLSRSSDGQFDLAEVIRC
                     FGEPEQTSQKIESSKQEGDESTKKLIAHLENEVKKYQEREERLMQQIDRMQTLIELKSV
                     APATAAPHQDATACDTKMPQHATTQQDTDNKKNNELNIAENVAVPQQETTAYHTQTLQH
                     ATLQSVAVPQHKKRGLFGRVLNAVFDND"
                     /name="plasmid replication DNA-binding protein"
     gene            9828..9971
                     /locus_tag="LOZ99_RS20640"
     CDS             9828..9971
                     /locus_tag="LOZ99_RS20640"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004786602.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001125246.1"
                     /translation="MPKLKDIALGIIVAPLLIPIMLIASYQDKKALKKELDECQKEKDQ
                     AS"
                     /name="hypothetical protein"
     gene            complement(10154..10981)
                     /locus_tag="LOZ99_RS20645"
     CDS             complement(10154..10981)
                     /locus_tag="LOZ99_RS20645"
                     /EC_number="3.5.2.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_057689930.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="OXA-24 family carbapenem-hydrolyzing class D
                     beta-lactamase OXA-72"
                     /protein_id="WP_000713530.1"
                     /translation="MKKFILPIFSISILVSLSACSSIKTKSEDNFHISSQQHEKAIKSY
                     FDEAQTQGVIIIKEGKNLSTYGNALARANKEYVPASTFKMLNALIGLENHKATTNEIFK
                     WDGKKRTYPMWEKDMTLGEAMALSAVPVYQELARRTGLELMQKEVKRVNFGNTNIGTQV
                     DNFWLVGPLKITPVQEVNFADDLAHNRLPFKLETQEEVKKMLLIKEVNGSKIYAKSGWG
                     MDVTPQVGWLTGWVEQANGKKIPFSLNLEMKEGMSGSIRNEITYKSLENLGII"
                     /name="OXA-24 family carbapenem-hydrolyzing class D
                     beta-lactamase OXA-72"
     ARG             complement(10158..10981)
                     /name="blaOXA-72"
                     /gene="blaOXA-72"
                     /gene_name="OXA-24 family carbapenem-hydrolyzing class D
                     beta-lactamase OXA-72"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     Typing          8291..9240
                     /name="rep_cluster_1172"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 tagcgaagta gtaaaatcaa atcaccaaac ccaattttac tattcgctat gcctcgtacc
       61 atgctgacag atcaacactg gcaaaagttg aaagttattc tgcgtaattt atccattcac
      121 cacaactcaa atttacgcaa ttttattgaa gctattctct atagaattag aacaggctgt
      181 ccgtggcgag atattccttc ttgttttggt cattccaact ctattttcaa acgttttaat
      241 cgttggtcaa gcagcggtaa gttacttaga ttattcaaat tactagcctc atgccccgat
      301 atggagtgga tttttattga tggctctcat gtacgtgctc atcaacattc tgccggcata
      361 gcgaatcaat ctatttctaa aagtgtagga ggaaactcct caaaaataca tttgattgtt
      421 gatgcacatg gcaatcctat tgatttcatg attaccgatg gaaccacaca tgatgttaaa
      481 gttgcgcctg atttaatatc aacattagat ttaaaagaga caaaagtggt atgcgcagat
      541 aaaggctatg attcagaacc actgcgtgaa cagatcagga aaacagggac taaagcgaat
      601 ataccaaaga aaacgaatag ccaatcgaac aatgaccata tggactggta tttatataaa
      661 atcaggcatt tagttgaaaa tatgttttgt agattaaagc aatttagagg aatagctact
      721 cgatatgaca agctcaaaag aaattatcaa agttctgttg ccttagcctg tatattttta
      781 tggctacctt tatagggtta attatgaaca gtaagtgtca acagacccta atttaacata
      841 atggcgatta tacgaagtac acttgtatat taatataaat atcaactact taataaaaat
      901 agaaaaatcc caaaatgccc aaaaagccga ctttgaaaca agtcggcttt tttatgagca
      961 gttttgatac ttcttgccaa taattttgac taaaaattac acgaatctgg ttgagtgata
     1021 caattttgtg atacattatt gtatatacaa atttgaatgt tttttatgga acagtatttt
     1081 gaatgggatg aggctaagaa tcgaaagaat cagaaaaagc atgatatctc tttcgaaact
     1141 gcaagccttg tttttgaaga tccattacgg atctcaatcc aagacagaca taccaatggt
     1201 gaagaacgtt ggcaaaccat tggacgagtt aaaggcgtac taatgttatt ggtggctcac
     1261 accatttttg atgaagatga ctgtgaaatc atccgaatca ttagtgcaag gcaagtcact
     1321 aaagcggagc gaaacaaata tgagcatggt tagatactca cacaaagagc tgaatgagaa
     1381 atttggtgag aagcaagatg ctgaaattca acgcttgctt gctaaaggca cggttcctga
     1441 tgatcagcta gatctatcag atattcctga aattacagac tggagcaatg ctgtacgcca
     1501 aaatcaattt taccgcccag taaagcaaca aacttcaatt cggttagatg ctgatgtact
     1561 tgcttggttc aaagcacaag gcaaaggtta tcaaacacgt atgaatgaaa ttttacgaga
     1621 tgctatgcta aaagaattaa aaaatcatca ataagaatgg gagcttaggc tcccattttt
     1681 gacttcattt ttagggggga ttaccattca aaaatttaaa tagtagattt tataaatttt
     1741 taagtgttat attataatat aacattaaat ttggttgttt tatgctaaat aaaagtaaac
     1801 tatttttagc tttaattact ttaggggcct cgaaaatttt attggcagct gaagggcctg
     1861 ttactacctt aaatacaata gtattaactg cacaatctga tgagttaggg tctgagctgt
     1921 taggcaaaag tctaaatgtt agtaatcagt ttattgatac tagtaaactt aaacagcgtt
     1981 cgacaactct aggggatgcc ttgggtacgg aattaggaat tcattctaat caatatggag
     2041 gtggagcatc tactcctatt attcgtgggc aggaaggaaa acgtattaaa gttttacaga
     2101 ataatgctga cgtgttggat atgtctaata tgtccccaga tcacgctgtc acagttgaac
     2161 caagtttagc taagtctatt gaaattatac gtggtgcaag tacccttttg tatagttcaa
     2221 atagtgcggc aggggtagtc aatgtcattg actataaaat tccaacccaa atgcctcaag
     2281 acggattaga gggtaatact acattacgtt ttaatactgg cagtaatgag aagttgacca
     2341 cagcaggtgt aacagttggc ttaagcccac atgtagcttt acgggcagaa gggttatatc
     2401 gtaatgctgg taactataaa actcctcatt accagtctag ctcttataat tctttagaag
     2461 atcttgaaaa ccaaaacagt atttataaaa atttaaaata tttaccagaa agctgggcag
     2521 agtcgagagt aggtacgctt ggattatcct ggatagacga taatacttat ttaggagttt
     2581 cttatacaca tcgtcatgat gaatatggtt taccagccca tagccattta tatgaaggtt
     2641 gtggtgcctc tgcaatcggt atcgattcac gaattagtgg attaaaaaat tatctgaaac
     2701 ctttgcacga ataaacacac aaaagtccat taaattggta taatacaata aaatcaatca
     2761 cctagcaaaa gacacgacta tggcatggaa acaaacaggg caactctccc tagcagacag
     2821 tctcattaac gctcacaaag ccatcgaaga attagatgaa ctacacaacc taattgactg
     2881 gcaaactatc gagcaaacct tacgccacgt tcatagcagt gagcgtgggg aatctgcctt
     2941 tcaccctgtc atcatgttta aagtattact cttacaaaaa ctctataacc tatcggatcc
     3001 agccatggaa aaacaactgg cacgagactt actatttcgt cgctttgttg gcctatcatt
     3061 aacggatgat gtacccgacc atagcaccat ttggcgatac cacaaacacc taggtgagct
     3121 tagactgatt gaaccattgt tcaaccaaat caatgagcaa ctagcccaac aaaacatttt
     3181 tatcaaagcg ggcagtgtca gcatcatcga tgccagtatc gttgaagcta aaaacaaacg
     3241 acctaagaaa ggcaaacaca ccgacaatac ccaagataac gaagccgcct atgtcagtaa
     3301 aaaagacagt acaggtaaag taaaaaccac ctacggcttt aaaattcatc tcaactgtga
     3361 tgaagacagc tttgtcaaaa aggttgaaac tacccctgcc aatgtccatg attcccaatg
     3421 ttttaccacg ctgttaacag atgatgaatc agccgtgtat gctgacagtg cgtataaaag
     3481 ccaagcccat gatgactacc ttgccgagca tgaaccaccg ataaaaaatc atattcatga
     3541 tagagcatgg cgcaatacac ccttaaccga acagcaaaaa cgcaataata cccaaaagag
     3601 ccaaactaga aacaccgttg agcgggtctt tggacatttt aaactgcatt atgggatgag
     3661 caaagctcgt catttagggt taatgcaatt tcataccagc actttgcttg caagcatggt
     3721 gcataattta aaaactgccc taagcttgaa acgaaaatac ggactcgcct agggttattg
     3781 tgcctgttgg ttagtaagct cagccaatag acacaaattt aacaaccatt tggagatttt
     3841 atccatgatt tagccattgt tttgcttatt tcattgccat tctttgtttt ttttcggttt
     3901 ggtggtatgc ctcgagcaaa ggggctgttt cgtgcaaagg tctctatctt ttatattatc
     3961 ctcaattgat ggatgagcaa gatattaatt acataaatcc acgtcctgat tgtcatcagc
     4021 ataatcatat tcatgaaact aatttctctc ataatgctcc ttatattgat ttaaatactc
     4081 gacgttatga tgtgcgtgga gaattcactc aaccatttac cggtattgac aaaattcgta
     4141 cctcattgag ttatatagat tattttcaca atgaactcga gggagataag attactaact
     4201 tttttaaaaa tacaggaaaa gtaggccgca tagagttatc acatcagcca ttaggggaat
     4261 taaccggtat cttggggcta caatatttgg aacaggataa tagtgcttta tcaccagtcc
     4321 attctcaaga aggccatacc acctatctag ataatcagca gctattaaat cgaaatgtca
     4381 ctaaaaactt tagtgtattt ggcctagaaa aatataactg gaacgacttt actttcgaac
     4441 taggtgctcg tatagaaaag cagaaagtta gtatggatta tgatatagaa aaaattaaag
     4501 attcaatgaa accttggcct aataaatata acagtcctta tgtagaaaaa aataataaaa
     4561 tcagggctca aaatttaaaa tctattttag aagctgttca acctaacaaa gaaacagctt
     4621 tttcttatgc aggtacagtc cactggagat ttgctccaaa ttatatctta tcattaacag
     4681 gtacacatca agaaagatta cctaatgcac aagaaatgta tactcatggt atgcatctcg
     4741 ctactaattc ttttgaaata ggtaaccgct ttctaagaaa agagaaatcc aataatttag
     4801 aaatcagtct ggcctataag gatgatttac ttgattatca aatcagtact tactattatg
     4861 attttgataa ctatatatat ttacagacac tcaatgaagt tttaggaact acaaaagtta
     4921 gagatcagca tacactacgt attaatcatt atagccagtc tgctgctaat ttttatggat
     4981 tagagggcaa catagggtat caatttaatt ctgtttatca cggctctctt tttggagatt
     5041 atgtgaaagg ccgtttaaca aatttacctg atgctgtaat tgcatacgat atctggaata
     5101 gagaaccgac tttagctccc caaaaggatc gttacactcc tagattacct cctgctcgtt
     5161 tgggtacacg actaaaagct gattttgatg aatcgcttaa aggtgaaata gaatattatc
     5221 gagtctttaa acaagataat atttctaaat ttgagcaggt tacatcaggt tataatatgc
     5281 ttaatatgac tttagcatat aaaaataagc tatctcacac agaatatgat ttattcttta
     5341 aagcgaataa tttacttgat cagaaagtct atgcccatga aacatttttg ccatatattc
     5401 cccaaattgg aagaaatttt agtttaggct taaatcttaa tttctagata agatactgta
     5461 atcttctaag aaaatttctt agaagatttt tcttataaaa tgattagatt aataattaag
     5521 gtaagcgtcc gctgaatccc atacctattt tttaattcga tttaggtttc cagcagtgtg
     5581 gcagtaactc ttcaatctgg gtcactttat gtgtcggcag ccttttcagc actgaatagc
     5641 caccgatttt gtagacacct tttagctaga taaaaagcaa tttttttgat ctttaaagaa
     5701 tgaggatata agctgtttaa aacttaattc taattggtta ataggtgaaa aatgaaatta
     5761 gcagaagctc tcttacttcg aagtgatcaa caaaaaaaaa ttatttcact aaaacaacgt
     5821 atcaatgcaa atgtattggt acaagatggt gatcaaccat ctgaagatcc aaatgaacta
     5881 ctaaaacaag tattttcttt aattcaagaa tttcaaaaat taagttatgc aattcatgaa
     5941 actaatgctt taacaaaatt aaatgatggc cgttctctac ttgctttatt gactttgcgt
     6001 gatgaatttg tagaacagca caaaacccta actgcagcaa taagtaatac atctcgtgaa
     6061 tctgatcgtt atagtacgcg ggaaataaag tggcataaag ttattccagt ttcatcatta
     6121 caaaaacaag ctgatgatat tagtcttaaa ttacgtgatt taaacgtgtt aattcagtcg
     6181 actaattgga aaattgattt gattgaagcc taatagtcct ttagatataa tcaagttgaa
     6241 catactgggc gagtacaaga tcccttactt ccacaacata ggattgtaaa taaagtgtag
     6301 tggcttgcaa agcaagtgga taagcttaaa attttaagta caaatcaatc catcacttgg
     6361 cataactcaa atctttgtgc aaacaaagtt acacgttact tataactacc atgtactgac
     6421 agtatgttca cctcaattac taaaaataaa gaaatgaaca agcatcagct caactacatt
     6481 tctattttta attcagttcg gcatttaaca taaaatctct tatacgaagc ccaggttaat
     6541 tctgggcttt ttgttcaatc tcatcattgg ccgagaacat acttggattc gtaagcctga
     6601 tattttcctg acaacttcca cacagcatca atcctgcaaa aagttgtaca ttttgtctat
     6661 tttcacaaag cgtacatggc tttgaaagct gaataatatt atctgacact actttaccct
     6721 cttatagtta tcatctgcat atgaataacc tttagcttgt atcattctaa cctcatcttt
     6781 agaagcgcca tttttcatta agagccacaa catcatgaaa tatagtccag aaaagtcttc
     6841 atagtatttt tcagaaaaat tgttatcttc ctcaaaatca tctattcgct tttctaatcg
     6901 attcaccaga tcctcaatac gatcggcttg ctgtttaaca gcaatagatt gaaaatcatt
     6961 ggtcaaaatt ttactgaata atttactggt tctgattcct tctgaattag ccaattgatc
     7021 gtagaattct gctacttgtg gatctaacct gactgcataa gttttgactt tttcgcccat
     7081 aaattacacc tcttattaaa attagatttt gtacaaaatt aaatatatat aattcaacta
     7141 attaaataaa aaataataat tagattacgt acaaacttat ttgtacagaa ttaatttatt
     7201 ctaaaacaaa aacttattta aatataatgc tttttttatg tacaatcatg agtacatatt
     7261 ttttcttaaa tttatcaata tcttatctaa aaaaagtgtt gttttgatgt acaaccatga
     7321 gcacagcata aaaaatagat aattcaatca cttattctaa aaaaagacca tttttctgta
     7381 cacgtttctg agaccctaaa aaatcgctga aatccttatc ctgtaaggct ttgaggggtg
     7441 tcatcgttag atgcgtggtg tgtgacaaaa aaatcccggc atgtgccgga tcttggattg
     7501 gaaaattggc taaagtgacg tagggccggt gcttggtttt gcatggaaaa aagtatttat
     7561 ttccttgttt agaaaaacgt aaaaaatcaa ttttttgtcc attcatccag gttaaaaatt
     7621 tcaacccaaa actttaatta tgaaaagctt catagaacgc gttcaaatgc gatttaagag
     7681 cctttaccta gaaaacatag atctcatagt gaaaaacaca aaacagctca aaaaacgcaa
     7741 atgagagcga aataaagagg tattttgact ttagatagat gcatagagcg agtgtctacg
     7801 agcgaactat caaaatttgc gcctagaccc tctgaaaaac atttttttgt cctctttagc
     7861 ctaagaaagc gtaagtttcg tgcagaaatt tgctcctgga tcgagcgtag cgagtaaaaa
     7921 agttttatga gcgaagcgaa ttccaagttt cttttgcttt tttttaaagt cacgccagta
     7981 ttaaccaaaa aattgcccca acgaactgag cgaaagcgaa gttcaataga gtttgagcga
     8041 agcgaaaacc aagggcaatt tttcattccc tgggctttta attattttaa agtttttaaa
     8101 tacttttaaa tggcttgaaa gccttatgaa taaagggttt tagctcttat atgtccacgt
     8161 ttaccttgca atatgtccac gtttaccttg caatatgtcc acgtttacct tgcaatatgt
     8221 ccacgtttac cttgcattag tacacaaata atattaacgt gtacttatac acaataaaaa
     8281 atagtggcta tgagagattt agttgtaaag gacaatgcct taatcaacgc aagctataac
     8341 ttagacttag tagaacaacg tttaatttta ttggctattg ttgaagcaag ggaaagtggg
     8401 aaagggatta atgcaaatga tccattagaa gttcatgcag atagttatat caatcaattt
     8461 ggtgtacacc gtaatacagc ttatcaagcc ttaaaagatg cttgtaagga tttattcgcg
     8521 cgtcaattta gctatcaaga gaaaaaagct aatgggaata tccgaaatgt tatgagtcgt
     8581 tgggtatctc aaattgctta taacgacaat gaagcaactg tagacttaat atttgcacct
     8641 gctgttgttc ccttcataac ccgactggaa gaacaattta ctaaatatga attacagcaa
     8701 gttagtagtc ttagtagcgc ttatgccatt cgcttatatg agcttctaat tcagtggcga
     8761 agcactggta aaaccccaac catagaacta caagaattta gaaagaagtt aggcgttctt
     8821 gataatgaat atttacggat ggctcattta aaagagcgtg ttttagagct ttcaattaaa
     8881 caaataaatg agcatacgga tataactgta aaatatgaac agcataaaag aggacgttct
     8941 atttcaggat tttcttttac ctttaaacag aagaagaagg atagcccatc aatagaaaga
     9001 gatccgaaca ctttggagct tttttcaaag atgaccgatg ctcaacggca tatgtttgca
     9061 aataaacttt cagaactccc tgaaatgggt cgctattcac aaggaacaga aagctaccaa
     9121 cagtttgctg tacgtattgc tgagatgcta caagatcccg ctcaattcaa agagctatac
     9181 ccatacctaa aaaaagtggg atacatgcca tcaaataaaa aggacaccgt aaatggctaa
     9241 gttatcacta agtgaagtat ctaaaaaatt tcatgtggat agatcaacca tttacagagc
     9301 tgtacgtaat ggacgtttat cacgctccag tgatggacaa ttcgatctag cagaggtcat
     9361 acgatgcttt ggagaacctg agcaaacatc tcaaaaaatt gaatcatcta agcaagaagg
     9421 tgatgaatct acaaaaaaac ttattgccca tttagaaaat gaagtcaaaa aataccaaga
     9481 acgtgaagaa cggttaatgc aacaaattga ccgtatgcaa acactcattg agctgaaaag
     9541 tgttgcacct gccacagcag caccacacca agatgctacg gcatgcgaca ccaagatgcc
     9601 acagcatgcg acaacacaac aagacactga taacaaaaag aataatgaat taaatattgc
     9661 agaaaatgta gcagtgccac agcaagaaac tacggcatac cacacccaaa cgctacagca
     9721 tgccacgttg caaagtgtgg cagtgccaca acacaaaaaa cgtggtttat ttggccgtgt
     9781 gctgaatgcc gtctttgata atgactgagc aataagggtg aaagatcatg ccgaaactga
     9841 aagacattgc cctgggaatt attgtagctc cgctgctgat cccgatcatg ctgattgcat
     9901 cgtaccagga taaaaaggcg ctgaagaaag agctggatga atgccaaaaa gaaaaagacc
     9961 aggcatcctg attattcaat tgagctaatc aaaagtgtgg aacattgatg aaataatagc
    10021 gtggaacgtg aaaagtcata aaaaaagccc gaacagggat gctcgggcta taaactagaa
    10081 actacagcgt tgaattataa ggataattat acagcatttc gtataaggcg tattatgtta
    10141 attttagaaa ttattaaatg attccaagat tttctagcga cttataagta atttcattac
    10201 gaatagaacc agacattcct tctttcattt ctaagttgag cgaaaagggg attttttttc
    10261 cattagcttg ctccacccaa ccagtcaacc aacctacctg tggagtaaca tccattcccc
    10321 atccactttt tgcataaatc ttactaccat ttacttcttt aattagaagc atttttttaa
    10381 cttcttcttg agtttctaat ttaaaaggta atcggttatg tgcaaggtca tcggcaaaat
    10441 taacttcttg tactggtgta attttaaggg ggccaactaa ccaaaaatta tcgacctgtg
    10501 ttccaatatt tgtatttcca aaattaaccc gctttacttc tttctgcatt agctctaggc
    10561 cagtccgtct tgcaagctct tgatatactg gaactgctga caatgccatt gcctcaccta
    10621 aagtcatatc tttctcccac ataggataag ttcttttttt accatcccat ttgaaaatct
    10681 catttgttgt tgctttatga ttttctagcc cgattaaagc atttagcatc ttaaatgttg
    10741 atgcagggac atattcttta tttgctcgtg caagagcatt accataggtg ctaagatttt
    10801 taccctcttt aataataatt acaccctgtg tttgagcttc atcaaaatag cttttaatag
    10861 ctttttcatg ttgctgagaa gaaatatgaa aattatcttc agatttagtt ttaatagatg
    10921 aacatgcact gagagaaact agaatagaaa tgctgaatat aggaagtata aattttttca
    10981 ttacaaattc atgttagggg aaattttggg gcttagagta taatattttt attaaaaaag
    11041 ttaaaactct tttagggtgt gttgacactt ttagcttaaa aaaa
//
