LOCUS       NZ_CP087269             9657 bp    DNA     circular CON 11-MAY-2024
DEFINITION  Aeromonas veronii strain HD6448 plasmid pHD6448-3, complete
            sequence.
ACCESSION   NZ_CP087269
VERSION     NZ_CP087269.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN20179696
            Assembly: GCF_022921155.1
KEYWORDS    RefSeq.
SOURCE      Aeromonas veronii (Aeromonas ichthiosmia)
  ORGANISM  Aeromonas veronii
            Bacteria; Pseudomonadota; Gammaproteobacteria; Aeromonadales;
            Aeromonadaceae; Aeromonas.
REFERENCE   1  (bases 1 to 9657)
  AUTHORS   Du,H.
  TITLE     Complete sequence of strain HD6448
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9657)
  AUTHORS   Du,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-NOV-2021) Department of Clinical Laboratory, The
            Second Affiliated Hospital of Soochow University, SanXiang, Suzhou
            215004, China
REFERENCE   3  (bases 1 to 9657)
  AUTHORS   Du,H. and Yang,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-JUL-2021) Department of Clinical Laboratory, The
            Second Affiliated Hospital of Soochow University, Sanxiang, Suzhou
            215004, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. v3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022921155.1-RS_2024_05_11
            Annotation Date                   :: 05/11/2024 05:15:48
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,942
            CDSs (total)                      :: 4,781
            Genes (coding)                    :: 4,618
            CDSs (with protein)               :: 4,618
            Genes (RNA)                       :: 161
            rRNAs                             :: 11, 10, 10 (5S, 16S, 23S)
            complete rRNAs                    :: 11, 10, 10 (5S, 16S, 23S)
            tRNAs                             :: 122
            ncRNAs                            :: 8
            Pseudo Genes (total)              :: 163
            CDSs (without protein)            :: 163
            Pseudo Genes (ambiguous residues) :: 0 of 163
            Pseudo Genes (frameshifted)       :: 42 of 163
            Pseudo Genes (incomplete)         :: 130 of 163
            Pseudo Genes (internal stop)      :: 15 of 163
            Pseudo Genes (multiple problems)  :: 23 of 163
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP087269.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..9657
                     /organism="Aeromonas veronii"
                     /mol_type="genomic DNA"
                     /strain="HD6448"
                     /isolation_source="hospital sewage"
                     /db_xref="taxon:654"
                     /plasmid="pHD6448-3"
                     /geo_loc_name="China:Suzhou"
                     /lat_lon="31.30 N 120.58 E"
                     /collection_date="2019-06"
                     /collected_by="The Second Affiliated Hospital of Soochow
                     University"
     gene            complement(join(9220..9657,1..681))
                     /gene="repC"
                     /locus_tag="KXU59_RS24530"
                     /old_locus_tag="LOS88_24530"
                     /old_locus_tag="LOS88_RS24530"
     CDS             complement(join(9220..9657,1..681))
                     /gene="repC"
                     /locus_tag="KXU59_RS24530"
                     /old_locus_tag="LOS88_24530"
                     /old_locus_tag="LOS88_RS24530"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="replication protein C, IncQ-type"
                     /protein_id="WP_245147301.1"
                     /translation="MSKHDLTHARHDPAHCLAPGLFRSLKRGERKRGKLDVVHDYGDGK
                     RIEFSGPEPLGADDLRILQGLVAMAGPGGLVLSPEPQTEAGQQLRLFLEPKWEAFQQDA
                     MVVKGSYRALAREIGYANPDDTKPVRECIERLWKVSIIAQNGRKRQGFRLLSEYASDEQ
                     DGKLYVALNPLIARAVMGGAQHVRIDMDEVRALQTDPARLMHQRLCGWIDPGKSGRVEL
                     DTLCGSGRGRQPTPIRSRRDAKRLAGRFLSLPHWAGQSANTQKTSLKSAGRKQRICSAQ
                     HPKHRKLAMRNDWETPPTVEVRIPVKLNSDSGICEHHFRKVCGQGFFEQKLGFEGRHLF
                     DSLNKPAAKRSAAVVDPRRWNRTVHLTSEYVL"
                     /name="repC"
     gene            complement(668..1531)
                     /locus_tag="KXU59_RS24535"
                     /old_locus_tag="LOS88_24535"
                     /old_locus_tag="LOS88_RS24535"
     CDS             complement(668..1531)
                     /locus_tag="KXU59_RS24535"
                     /old_locus_tag="LOS88_24535"
                     /old_locus_tag="LOS88_RS24535"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014003865.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helicase RepA family protein"
                     /protein_id="WP_012537710.1"
                     /translation="MAINIMEAFQQEPPQLDFIWPGFLAGTVGALVAPGATGKSFWALE
                     AAMSIACSVAGGDVVNLKPQHTGRVVYLAGEDPEPALIRRVHAIGQHLNQSAREAIAEN
                     LTLEPIMGKRLNVMDEEHLRRVIEYSAGARLIVLDTLSRIHSLDENSNGDMARLVATLE
                     HVAASTGASVLYLHHVSKGSAREGQTDQQQAARGASALIDNARWCGFVAKMTEDEAKRL
                     SDRAYDRQPIGNDRRGFFVRFGVSKQNYDATPLDQWYERRDGGVLVPVELLEVPNGKKG
                     GSREQA"
                     /name="helicase RepA family protein"
     gene            complement(1602..2552)
                     /locus_tag="KXU59_RS24540"
                     /old_locus_tag="LOS88_24540"
                     /old_locus_tag="LOS88_RS24540"
     CDS             complement(1602..2552)
                     /locus_tag="KXU59_RS24540"
                     /old_locus_tag="LOS88_24540"
                     /old_locus_tag="LOS88_RS24540"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_043849884.1"
                     /translation="MKREGRHLSVKAGGDEAYRVTRQQDGRWLWCDRYGNDGGDNIDLV
                     REIEPGTGYAEAVYRLSGAPTVRQQPRPSEPKRQPPQLPAQGLAAREHGRDYLKGRGIS
                     PDTIEHAEKAGMVRYADGGVLFVGYDRTGTAQNATRRAIAPADPVQKRDLRGSDKIYPP
                     ILPGDPAKVWIVEGGPDALALHDIAKRSGQQPPTVIVSGGANVRSFLERDDVQAILKRA
                     ERVTVAGENEKNPEAQAKADAGHQKQAQRVAEITGREVRQWTPKPEHGKDLADMNARQV
                     AEIERKRQAEIEAERARNRELSRKSRGYDGPSFGR"
                     /name="hypothetical protein"
     gene            complement(2588..3271)
                     /locus_tag="KXU59_RS24545"
                     /old_locus_tag="LOS88_24545"
                     /old_locus_tag="LOS88_RS24545"
     CDS             complement(2588..3271)
                     /locus_tag="KXU59_RS24545"
                     /old_locus_tag="LOS88_24545"
                     /old_locus_tag="LOS88_RS24545"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_043849885.1"
                     /translation="MTKLETVRALNDSGPQLQIVESVRTLQQSLSLMHEDLKRLPVAVS
                     TETAQTLEPLARLQQDVTQVLEAYDKVTAIQRKTLDELTQQMSASAAKAFEQKAGELDK
                     TISDLSNSLSGLETSISSMKQTAEQVADLPGNLVSAQKDMTQAANKLTEAANETRPRLW
                     RQALGLILAGAVGAMLVATGQVALNRLVPPSDVQQTADWANAIWNKATPKERELLEQIV
                     NRPAN"
                     /name="hypothetical protein"
     gene            3480..3836
                     /locus_tag="KXU59_RS24550"
                     /old_locus_tag="LOS88_24550"
                     /old_locus_tag="LOS88_RS24550"
     CDS             3480..3836
                     /locus_tag="KXU59_RS24550"
                     /old_locus_tag="LOS88_24550"
                     /old_locus_tag="LOS88_RS24550"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_043849886.1"
                     /translation="MQTLARRFVARSHGHVDLLVGQLPALGPRIAQPRRQGQAVGMLKL
                     LGRLDGAAGFPLAQPNFPVQPYPAGHDVDVILVRVLVAHCHPRRIGLVKAHALHEVSRH
                     GFPLLGAQALTGRQ"
                     /name="hypothetical protein"
     gene            complement(4027..4458)
                     /locus_tag="KXU59_RS24555"
                     /old_locus_tag="LOS88_24555"
                     /old_locus_tag="LOS88_RS24555"
     CDS             complement(4027..4458)
                     /locus_tag="KXU59_RS24555"
                     /old_locus_tag="LOS88_24555"
                     /old_locus_tag="LOS88_RS24555"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004171598.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid mobilization relaxosome protein MobC"
                     /protein_id="WP_012537712.1"
                     /translation="MNTDESKRRRRGPAPLDATDKRGHTVSVRLNDAELARLDSQRDAV
                     QMQRGEYLRAAALHRLPPTIPAANREQWAELARTAANLNQIARHLNEGQRGDGERIGKA
                     LGLQLSAELANCLRLLVLVRGDLIGVKHDSEDVEDESEG"
                     /name="plasmid mobilization relaxosome protein MobC"
     gene            4916..5383
                     /locus_tag="KXU59_RS24560"
                     /old_locus_tag="LOS88_24560"
                     /old_locus_tag="LOS88_RS24560"
     CDS             4916..5383
                     /locus_tag="KXU59_RS24560"
                     /old_locus_tag="LOS88_24560"
                     /old_locus_tag="LOS88_RS24560"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_012954630.1"
                     /translation="MQFKRQGRRVQVLAYRGYDKEKRRAIVKMMGSIDVYSYEPSGGLI
                     ENLTDEEKTELQSYIETERQAAEKRSRVYYAKSAASRIVEVADTIKAGDFEPSEAWAAD
                     TWAAIEALTKAMRKAGYPKLRKAPQKAADAPMPGQAGLPFGDAPETPESAS"
                     /name="hypothetical protein"
     gene            5957..7534
                     /locus_tag="KXU59_RS24565"
                     /old_locus_tag="LOS88_24565"
                     /old_locus_tag="LOS88_RS24565"
     CDS             5957..7534
                     /locus_tag="KXU59_RS24565"
                     /old_locus_tag="LOS88_24565"
                     /old_locus_tag="LOS88_RS24565"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001513488.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PAS domain-containing methyl-accepting chemotaxis
                     protein"
                     /protein_id="WP_101862731.1"
                     /translation="MRQNLPVTGRNLELPKDTNILSTTSPQSHITYVNPDFIKISGFTE
                     EELLGQPHNIVRHPDMPPAAFEHMWSTLKSGRSWMGLIKNRCKNGDHYWVSSYVTPIAK
                     NGSIVEYQSVRTKPEPEQVLAAEKLYAQLRSGKAARPKLAASFSVKILLLIWGSIISSA
                     MAAGMLTDTSISSLLLATLMSGSLSSVSVLAILSPLGRLVERARNISNNPLSQSIYTGR
                     TDEFGQIEFALRMMQAETGAIVGRIGDASNRLSEHTRGLLKDIESSNVLTVEQQAETDQ
                     IATAVNQMAASIQEVASNAQHAADAAGRADTETASGQRLVAHTSQSITALEGEIRQAAQ
                     VIHELEGQSNEISKVLDVIRGIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRSLAA
                     RTQQSTTDIQSMISALQERAQSAVTVMEQSSRQADTSVAHAEEAATALDGIGQRVNEIT
                     DMNAQIATAVEQQGAVSEDINRSIINIRDAADTNVQTGQNNLQSAKSVAQLTSALSELA
                     KQFWEKRG"
                     /name="PAS domain-containing methyl-accepting chemotaxis
                     protein"
     gene            8261..8917
                     /locus_tag="KXU59_RS24570"
                     /old_locus_tag="LOS88_24570"
                     /old_locus_tag="LOS88_RS24570"
     CDS             8261..8917
                     /locus_tag="KXU59_RS24570"
                     /old_locus_tag="LOS88_24570"
                     /old_locus_tag="LOS88_RS24570"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001516695.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="quinolone resistance pentapeptide repeat protein
                     QnrS2"
                     /protein_id="WP_012537714.1"
                     /translation="METYRHTYRHHSFSHQDLSDITFTACTFIRCDFRRANLRDATFIN
                     CKFIEQGDIEGCHFDVADLRDASFQQCQLAMANFSNANCYGIELRECDLKGANFSRANF
                     ANQVSNRMYFCSAFITGCNLSYANMERVCLEKCELFENRWIGTHLAGASLKESDLSRGV
                     FSEDVWGQFSLQGANLCHAELDGLDPRKVDTSGIKIASWQQEQLLEALGIVVFPD"
                     /name="quinolone resistance pentapeptide repeat protein
                     QnrS2"
     ARG             8262..8914
                     /name="qnrS2"
                     /gene="qnrS2"
                     /gene_name="quinolone resistance pentapeptide repeat
                     protein QnrS2"
                     /tool="amrfinderplus"
                     /drug_class="QUINOLONE"
                     /identity="100.0"
                     /coverage="100.0"
     Typing          complement(669..1531)
                     /name="IncQ2"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="98.495"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(1606..4043)
                     /name="MOBP"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="98.401"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 gccgcaaagc gtgtccagtt ccacccgccc ggacttgccg gggtcgatcc agccgcatag
       61 gcgctggtgc atcagccgcg ccgggtcggt ctgtagcgcc cgcacctcgt ccatgtcgat
      121 gcggacatgc tgcgcgccac ccatgacggc gcgagcaatc aggggattca aggctacata
      181 cagctttccg tcctgctcgt cgctggcgta ctcggacagc aggcggaagc cctgccgctt
      241 cctgccgttc tgggcgatga tggacacctt ccaaagccgc tcgatgcact cccgaaccgg
      301 cttagtgtcg tcggggttgg cgtagccaat ttcgcgggca agtgctcgat agctgccctt
      361 gaccaccatc gcatcctgct ggaaggcttc ccatttcggc tcaaggaaca gccggagttg
      421 ctgcccggcc tcggtctgcg gctcaggtga cagcacaagg ccacccggcc cagccattgc
      481 cacaagtcct tgcaggatgc gcaagtcatc agcgcccagc ggctccgggc cgctgaactc
      541 gatgcgctta ccgtcgccat agtcatgcac cacgtccagc ttgccgcgct tgcgctcgcc
      601 acgcttgagg ctgcggaata ggccgggggc cagacaatgc gccgggtcgt gccgggcgtg
      661 ggtcaggtca tgcttgctca cggctgcccc ccttcttgcc gttcggcact tccagcagtt
      721 ccaccggaac cagcacgccg ccgtctcggc gctcatacca ctggtcaagc ggggtggcgt
      781 cgtagttctg tttgctcacg ccgaagcgca cgaagaagcc gcgccggtcg ttgccgatgg
      841 gctgacggtc ataggcgcgg tcgctcaggc gcttggcctc gtcctcggtc atcttggcga
      901 cgaagccgca ccagcgggcg ttgtcgatca gtgccgatgc gccccgcgct gcctgctgct
      961 ggtcggtttg cccctcgcgg gcgctgccct tgctgacgtg gtgcaggtac aggacagacg
     1021 cgccagtgct ggccgcgacg tgttccagcg tggcgacaag ccgcgccatg tcgccgttgc
     1081 tgttctcgtc gaggctgtga atccggctca gggtgtccag cacgatcagc cgcgccccgg
     1141 cgctgtactc gatgacgcgg cgcaagtgct cctcgtccat gacgttcagg cgcttgccca
     1201 tgatcggctc aagggtcagg ttctcggcga tggcttcgcg ggctgactgg ttgaggtgct
     1261 ggccgatggc gtgaacgcgc cggatcaggg cgggttcggg atcttcaccg gccagataga
     1321 ccacgcgccc ggtgtgctgc ggcttgaggt tcaccacgtc accgcctgcc acgctgcaag
     1381 cgatggacat agccgcttcc agcgcccaga agctcttgcc ggtcgcgccg ggggccacca
     1441 gtgcgcccac ggtgccagcc agaaagccgg gccagatgaa gtccagttgt ggcggttcct
     1501 gctggaacgc ctccataatg ttgatagcca tatcggcctc ctactcaggt tgatgatggt
     1561 tagcctgtcg gtcggttcat cacaccgact gacaggcgct cttatctgcc gaagctgggg
     1621 ccatcatacc cccggctctt gcgtgaaagc tctcgatttc gcgctctctc agcctcgatc
     1681 tcggcctgtc gcttgcgctc gatctctgcc acctgccggg cgttcatgtc ggccaagtct
     1741 ttgccatgct cgggcttcgg cgtccattgg cgcacctcgc gcccggtgat ttcggccacc
     1801 cgctgcgcct gtttctggtg cccggcgtcg gccttggcct gcgcctcggg gttcttttcg
     1861 ttttccccgg ccacagtgac gcgctcggcc cgcttcagga tcgcttgcac gtcgtcacgc
     1921 tccaagaagc tgcgcacgtt cgcgccgcct gacacgatga cggtgggcgg ctgctggccg
     1981 ctgcgcttgg cgatgtcgtg cagggctagc gcatccgggc caccttccac gatccagacc
     2041 tttgccgggt cgcccggcag gatcggcgga tagatcttgt cgctgccgcg taagtcgcgc
     2101 ttctgcaccg gatcagcggg ggcaatggcg cggcgtgtgg cgttctgcgc ggtgcctgta
     2161 cggtcgtagc cgacgaacag cacgccaccg tctgcatagc gcaccatgcc cgccttctcg
     2221 gcgtgctcga tggtgtccgg gctgatgccc cggcccttga ggtagtcgcg gccatgctcg
     2281 cgggctgcca gcccttgcgc cggtagctgc ggcggttggc gtttcggctc gctcgggcgc
     2341 ggttgctgcc ggactgtcgg cgcacctgaa agccgataga cggcctcggc gtagccggtg
     2401 ccaggttcga tctcgcgcac aaggtcgata ttgtccccgc cgtcgttgcc gtagcggtcg
     2461 caccagagcc agcgcccgtc ctgctgccgg gtcacgcggt acgcctcatc accgccagcc
     2521 ttgacggaca ggtgtcgccc ttcgcgcttc acggtgtagc cgctcgcctc aaggtaggcg
     2581 gtcggatcta gttcgcgggc cgattgacga tctgttccag caactcgcgc tccttgggcg
     2641 tggccttgtt ccaaatcgcg ttggcccaat ccgccgtctg ctgcacgtcg cttggcggca
     2701 ctagcctgtt taaagcgact tgcccagtcg ctaccagcat cgcgcccacg gccccggcca
     2761 gaatcagccc cagcgcctgc cgccaaaggc gcgggcgcgt ctcgttcgct gcctcggtca
     2821 gtttgttggc ggcttgcgtc atgtccttct gtgcgctcac cagattgccc ggcaagtccg
     2881 ccacctgctc cgcggtctgc ttcatgctgc tgatgctcgt ttccagccct gacaggctgt
     2941 tggacaggtc ggagatggtc ttgtccagct ccccggcctt ctgctcgaac gccttcgccg
     3001 cgctcgcgct catctgctgc gtcagctcgt ccagcgtctt gcgctgaatg gccgtcacct
     3061 tgtcgtaggc ttccagaacc tgcgtcacgt cctgttggag tcgggccagc ggttccaagg
     3121 tctgcgccgt ctcggtcgag actgcgaccg gtaggcgctt caagtcctcg tgcatcaggc
     3181 tcagggactg ctgcaacgtc ctgacgctct ccacgatctg caactgtggg cctgaatcgt
     3241 tcaaggcccg cacggtctct agcttcgtca taagtcaccc ctgatttctg tagtcccgcc
     3301 catgtgtagc ccttgcccaa gtcgctgccc ttgaacggca ctccggccac ctcgaaggaa
     3361 aagccgttca tgcgcccggt gctggcgagg tttgcccgga cgcctacgcc tgcggcatgt
     3421 agccggtcgg ccagttctgg cgcggtcggc ttgtccttca ctgcctcatc cagcagccgt
     3481 tgcagacgct ggcgcggcgg ttcgtcgccc gttctcacgg ccatgttgat ctccttgtcg
     3541 gtcagcttcc ggcgctcggc ccgcgcatcg cccagccccg gcgtcagggt caggccgtgg
     3601 gtatgctcaa gctcttgggt cgcctcgatg gcgctgcggg cttcccactg gcccagccaa
     3661 actttcccgt ccagccctac ccggctggcc acgatgtgga tgtgatcctt gtccgtgtcc
     3721 tggtggcgca ctgccaccca cggcgtattg gtctggtcaa agcccatgcg ctgcatgaag
     3781 tcagtcgtca cggcttccca cttctcggcg ctcaggcgct caccgggagg cagtgacagc
     3841 gagcaatgcc agacgggctt gccgatgtcc gggcgcaact ggcgcacggc tgagaactcc
     3901 cgcgacagtt cgcgggggtc attcccggcc atgttgccgc cgacacgttc cgcgtttttc
     3961 gtgtgcgtgg cttccttgcc aacgtcaaaa acgtagttca gcgcaccgcg aaaaccgcca
     4021 ccacggctaa ccttcgcttt catcttccac gtcctccgag tcgtgcttga cgcctatcaa
     4081 gtcgccgcgc accagaacca gcaatcgcag gcagttggca agctcggcgc tcaactgcaa
     4141 gcccagcgcc ttgccgatgc gctccccgtc gccccgctgc ccttcgttca ggtgccgggc
     4201 gatctggttc aggttggccg ctgtgcgggc caactctgcc cactgttccc ggttcgctgc
     4261 cgggatggtg ggcggcaggc gatgcagagc ggcggcgcgt aggtactcgc cccgctgcat
     4321 ctgcaccgcg tcacgctgcg aatccagccg cgcaagctcg gcatcgttga ggcgcaccga
     4381 aacggtatgc ccgcgcttgt ccgtggcgtc gagcggcgca ggcccacggc ggcggcgctt
     4441 ggattcgtca gtgttcatgg gcgaagccct ccagtaagtg aagcgaagcg aaacgcgcag
     4501 caaccccccg accgaaggga gcgggggcgt aggccgaagg ccggagggtg agaaccaagc
     4561 gaagcgtagg ttacaccttg ctccatgcca aaccaccgcg caaataccat aatagcacat
     4621 ctccatgcaa gcaccgaaca gccacccacc cggcccgctc gctgcgctct cggcccgacc
     4681 gcccaagggc ggtaatgggc cagcggggag agggggtggg caaggcgccg gggcgaactg
     4741 atacaatgca actatggtat cgcaagaacg gcagactgtc gagcgttact caatccgaca
     4801 gtgcaaacct atttgagtgc gacggtcgga ttgaaaaata ggccgacaat aaacactcga
     4861 cagcgtgcga ctgtcgaact ataatataat cacacagtca aacggagaaa ccgccatgca
     4921 gtttaagcgc caaggtcgcc gggttcaggt gctcgcctac cgggggtatg acaaggaaaa
     4981 acgccgcgcc atcgtcaaga tgatggggtc tattgacgta tattcttacg agccgtcagg
     5041 cggcctaatt gagaatctga cagacgaaga aaaaacagaa ctacagtcat acatcgaaac
     5101 agaacgacag gcagcagaaa agagaagccg agtgtattac gctaagtctg ccgccagtcg
     5161 tattgttgag gttgccgaca cgatcaaggc cggggacttt gagccgtccg aggcatgggc
     5221 ggcggatacc tgggcggcaa tcgaggcgct gaccaaggcc atgcgcaagg cgggctaccc
     5281 gaagctccgc aaagcgcccc agaaagccgc agacgcgccg atgccgggtc aggcggggtt
     5341 gccctttggg gatgcgccag aaacgccaga aagcgcctcc tgaggggttt aggccgggaa
     5401 accggcaccc ccccccctct ccccgctggc cctttacccc cggagggggt cgccgaaggc
     5461 ggggggagag gtgttcgcct tgcgcatggt cttggccggg catttgaggc aatgccagac
     5521 cgcgccgaag gggcgcgggc tgtgctgcgc ctagtggaga ttcttagaga atcttggatg
     5581 gattttgcga atcgccagca aatccgcgcc ccgtctgggt tttccagatc ggggcgggtg
     5641 gagttaccgt gggggttggg tggagttacc gtgggggttg ggtggagtta ccgtgggggt
     5701 tgggtggagt taccgtgggg gttgggtgga gttaaacagg gggtcacaca tactcgcacc
     5761 agatcacgct gccccagtgc tcgccggttt ccggctcaat ggctacgtta tcgaagcgcc
     5821 ctcctgagta gatcaggcaa cgcttcccaa tcagcctagc ggggtcggtg tagccatgct
     5881 agcttatcgt aacgctaaag aaattgggct taatgccgag tacaataaaa taaaacagcc
     5941 aaccattgag gctcttatgc gccagaattt accagtgacg ggtcgaaact tagaactccc
     6001 aaaagatacc aatattcttt cgactacctc ccctcaaagc catatcacgt acgttaatcc
     6061 tgacttcatt aaaatcagtg gtttcactga ggaagaacta ttaggccagc ctcacaacat
     6121 cgtaagacac ccagatatgc cgcctgctgc atttgagcat atgtggagta cattaaaatc
     6181 tggccgctca tggatggggc taataaaaaa tcgctgtaaa aatggcgacc actattgggt
     6241 aagttcttat gtaacgccaa tagctaagaa tggttcgatt gttgaatacc agtctgtaag
     6301 gaccaagcct gaacctgagc aggttttggc tgcggaaaaa ttatatgctc aattgagaag
     6361 cgggaaggcc gcgaggccga aattggctgc tagcttttcc gtgaaaatac tcttgctcat
     6421 atggggtagt attatatcga gcgcaatggc tgccggcatg cttactgata catcaataag
     6481 cagcttattg ttagccactt taatgtcagg aagcttaagc tctgttagtg ttttggctat
     6541 tctctctcct cttggaagac tggttgaaag agccaggaat atttccaata acccattaag
     6601 tcaatccatc tacactgggc gcaccgatga gtttggccaa atagagtttg ctttacgaat
     6661 gatgcaagct gaaacaggcg ccatagtagg tcgcataggt gatgcatcaa atcggcttag
     6721 cgaacacacc cgaggcctac taaaggatat tgagtcaagc aatgtactta cagttgagca
     6781 gcaggcagag acagatcaaa tagcaacggc agtaaaccaa atggcggcaa gcattcaaga
     6841 ggttgcgagc aatgcacagc atgctgcaga tgcggccgga agagcagaca ctgagacggc
     6901 atctggccag cgtctggtag cccacacaag ccagtcaatc actgcccttg aaggtgaaat
     6961 taggcaagcc gctcaggtta ttcatgagct tgaaggtcaa agtaacgaga tatcaaaagt
     7021 tcttgacgtt atacgaggga tcgccgagca aacgaatttg ttggcactca acgcagcaat
     7081 tgaggccgcg cgtgctggtg agcaggggcg tggttttgct gttgtcgccg atgaggttcg
     7141 cagtcttgct gctcgcacac agcaatcgac aacggatatt caaagcatga tcagcgctct
     7201 acaagagcga gcgcaatccg ctgttacagt catggagcaa agtagtcggc aagcggacac
     7261 gagtgtagct cacgcagagg aagcagctac agctcttgat ggaattggcc aacgcgttaa
     7321 cgaaattacc gacatgaacg cgcaaatagc gactgcggtc gagcagcagg gagcagtaag
     7381 tgaagacata aaccgcagta ttatcaatat acgcgatgct gctgatacca atgtacagac
     7441 cgggcagaat aatttgcaaa gtgcgaaatc tgtcgctcag ttaactagcg ctctgagcga
     7501 actggcaaaa cagttttggg aaaaacgagg ataacgcttt tcagtatctc gacagggata
     7561 acttacttta ccatcggtat cccttttagc cgcacaaatt ttagccatgg cttttcagga
     7621 agtcatggct atcagaatgg ccttagaaag cctagtcaaa gagctgtcac gagaacaccg
     7681 ttagcttagc gtacgatttt ttccgaattc tgcggttccc ccatcctcgc caatccaagc
     7741 ccggacaatc agcccttcgt gcatattccg gtcgaaaatg aacacctatt ccggtttaaa
     7801 atgaacgctg attccggctt gcgtgtacac cgattccgga cacctgtgtg agtagaataa
     7861 agtttcgtta ctaagtaata aagaatcata ctgagtatta aagattcata cttaaatggc
     7921 agcgatcaga gtacactgcc atttctaaaa cgtttatgcc ccattccttc ttagaccttg
     7981 tatctacttc aaattgcagg cttccgttta aggttacttt acctaatggc ggacatcagt
     8041 aatctattgg gttccttttc tctgtggctt tttaagcgga taactttttt caatggtgcc
     8101 gcgtactttg aacgttaaca tagaggctca gggcgctatt ttaccccctt aaaataggca
     8161 aaatgagggt ttttaagatc ttgattttta gtgtttttat tttggtgatg tgatgtggct
     8221 ttgatggtag tgttgcgtcc agttcatcat aggagtcaac atggaaacct accgtcacac
     8281 atatcgacac cacagttttt cacatcaaga tctaagtgat attactttca ctgcttgcac
     8341 ctttatccga tgcgattttc gacgtgctaa cttgcgtgat gcgacattta ttaactgcaa
     8401 gttcattgaa cagggtgata tcgaaggttg ccattttgat gtcgcagacc ttcgcgatgc
     8461 aagtttccaa caatgccagc ttgcgatggc aaactttagt aacgccaatt gctacggtat
     8521 tgagttacgt gagtgtgatt taaaaggggc caacttttcc cgagcaaact ttgccaatca
     8581 agtgagtaat cgtatgtact tttgctcagc ctttattact ggatgtaacc tgtcttatgc
     8641 caatatggag cgggtctgtt tagaaaaatg tgagctgttt gaaaatcgct ggatagggac
     8701 tcacctcgcg ggcgcatcac tgaaagagtc agacttaagt cgaggtgttt tttctgaaga
     8761 tgtctgggga cagtttagcc tacagggtgc taatttatgt cacgccgaac tcgacggttt
     8821 agatcctcga aaagtcgata catcaggtat caaaattgcc agctggcaac aagaacagct
     8881 tctcgaagcg ttgggtattg ttgtttttcc tgactagatg cttacgaata cctgctgata
     8941 aactatacac aacattaata cattttctaa ttcaaatcac cagagctaga tcaatacttc
     9001 tagctcattc ttgtccagaa acgtgtttga atggggccaa tcaatctgtg gatgctcaag
     9061 acaaccagta tgatacttta ttactcagtt gtagcgtgac tcagattttg tagtaggaat
     9121 tagtatgaat ctttatttct gggtgagtat catttagaac ggtacaaaca gggttacttg
     9181 actgcttagt atgaaacttt attcctctcc tacaacacct cagagcacgt actctgatgt
     9241 cagatgaacc gtcctgttcc aacgtcttgg atccacaact gccgcgctgc gcttggctgc
     9301 tggcttgttc agtgagtcga aaagatgcct cccctcaaag cccagcttct gctcgaagaa
     9361 tccctgtccg catactttcc ggaaatggtg ttcacagatt ccggaatcac tgttcaactt
     9421 caccggaata cgcacttcga ctgtcggcgg cgtttcccaa tcatttctca tggctaattt
     9481 cctgtgtttt gggtgctggg ccgagcagat gcgttgcttt cggcctgccg atttcaaact
     9541 tgttttttgc gtattcgctg actgcccagc ccaatgcggc aagctcagga agcgccctgc
     9601 gagccgcttg gcgtcgcgtc ttgagcgtat tggggttggt tgcctgcccc ggccaga
//
