LOCUS       NZ_CP085910            23177 bp    DNA     circular CON 24-DEC-2023
DEFINITION  Enterococcus faecium strain SC1762-D plasmid p4, complete sequence.
ACCESSION   NZ_CP085910
VERSION     NZ_CP085910.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN22627489
            Assembly: GCF_020736625.1
KEYWORDS    RefSeq.
SOURCE      Enterococcus faecium
  ORGANISM  Enterococcus faecium
            Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
            Enterococcus.
REFERENCE   1  (bases 1 to 23177)
  AUTHORS   Zeng,W.
  TITLE     Acquisition of daptomycin resistance by Enterococcus faecium confers
            collateral sensitivity to glycopeptides
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 23177)
  AUTHORS   Zeng,W.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-OCT-2021) Laboratory Medicine, College of Life
            Sciences, Wenzhou Medical University, Wenzhou Medical University,
            Wenzhou, Zhejiang 325000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: unicycler v. v0.4.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 120.0x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 12/23/2023 20:46:10
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,310
            CDSs (total)                      :: 3,219
            Genes (coding)                    :: 3,060
            CDSs (with protein)               :: 3,060
            Genes (RNA)                       :: 91
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 159
            CDSs (without protein)            :: 159
            Pseudo Genes (ambiguous residues) :: 0 of 159
            Pseudo Genes (frameshifted)       :: 63 of 159
            Pseudo Genes (incomplete)         :: 94 of 159
            Pseudo Genes (internal stop)      :: 41 of 159
            Pseudo Genes (multiple problems)  :: 30 of 159
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP085910.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..23177
                     /organism="Enterococcus faecium"
                     /mol_type="genomic DNA"
                     /strain="SC1762-D"
                     /host="Homo sapiens"
                     /db_xref="taxon:1352"
                     /plasmid="p4"
                     /geo_loc_name="China:wenzhou"
                     /collection_date="2018"
     gene            1..1041
                     /locus_tag="LLE91_RS16120"
                     /old_locus_tag="LLE91_16120"
     CDS             1..1041
                     /locus_tag="LLE91_RS16120"
                     /old_locus_tag="LLE91_16120"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002343466.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /protein_id="WP_002302900.1"
                     /translation="MNDFNYYKSKEIYREKYYQMPKVFFTNEKYMDLSNDAKIAYMLLK
                     DRFDYSVKNNWVDSDDNIFFIFTVEELMKLLQCREGKVSKIKKELEKAGLLKQKRGRVN
                     KRDGKIESMPNLLYLGKPEVTNQDVFKIMEEEDNTDSTVIAKIANTAKPRKINDSTVIA
                     KIANTAKSSHIKDSTVIAKIADNLFYSNSIDTNRHIIDTETDQLQNQVLLDNFVDIMQE
                     DSINTFVPENVLNLIKTFSSSYSEAQQTVQTIHNAKKKAEELEQTIVVYEELESYGIDA
                     DKGLYMTLLKAYQKQKTEKVNNLQNLIFVYVKNWFVEKAIAAKLANEQRETFNELPTVS
                     TENWLE"
                     /name="replication initiator protein A"
     gene            complement(1661..2341)
                     /locus_tag="LLE91_RS16125"
                     /old_locus_tag="LLE91_16125"
     CDS             complement(1661..2341)
                     /locus_tag="LLE91_RS16125"
                     /old_locus_tag="LLE91_16125"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="WP_001015311.1"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            complement(<2418..2564)
                     /locus_tag="LLE91_RS16130"
                     /old_locus_tag="LLE91_16130"
                     /pseudo=""
     CDS             complement(<2418..2564)
                     /locus_tag="LLE91_RS16130"
                     /old_locus_tag="LLE91_16130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002311815.1"
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006270 - DNA replication initiation
                     [Evidence IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="RepB family plasmid replication initiator
                     protein"
                     /name="RepB family plasmid replication initiator protein"
     gene            3248..3334
                     /locus_tag="LLE91_RS16135"
                     /old_locus_tag="LLE91_16135"
     CDS             3248..3334
                     /locus_tag="LLE91_RS16135"
                     /old_locus_tag="LLE91_16135"
                     /inference="COORDINATES: protein motif:HMM:NF033608.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="WP_125669474.1"
                     /translation="MFTNFICSLLVGLLSALFSYWLNNRNKK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            complement(3635..3859)
                     /locus_tag="LLE91_RS16140"
                     /old_locus_tag="LLE91_16140"
     CDS             complement(3635..3859)
                     /locus_tag="LLE91_RS16140"
                     /old_locus_tag="LLE91_16140"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000410576.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000410576.1"
                     /translation="MEKFPYEYFQNLEKLEQAIQAIKFDLTDEKLLEYKNMTPERKRSL
                     EKLMQLVNEDGGISDAAFDAWSEFHGEYN"
                     /name="hypothetical protein"
     gene            4225..4506
                     /locus_tag="LLE91_RS16145"
                     /old_locus_tag="LLE91_16145"
     CDS             4225..4506
                     /locus_tag="LLE91_RS16145"
                     /old_locus_tag="LLE91_16145"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000353845.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_086325443.1"
                     /translation="MDILVRNIDPKFVATIDKRCQELTNKTGEKWSRNKYLKVLIESDF
                     DRQLTTYKKDQFDLLLDKFIAIQTENTQILSEYVYTNNQIIEMLIGGI"
                     /name="hypothetical protein"
     gene            4508..4924
                     /locus_tag="LLE91_RS16150"
                     /old_locus_tag="LLE91_16150"
     CDS             4508..4924
                     /locus_tag="LLE91_RS16150"
                     /old_locus_tag="LLE91_16150"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001232859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001232859.1"
                     /translation="MRKTSVQKHVTLYPSHVDVLDSIIEKNPDINNYSEAIRFLCMSYE
                     PDTNTTTTSNQAKLNAMGKEISIMTEIIAEFADLYLKDTGVLIGTNSKVYQEVKEKIEA
                     KLNPSNRNRPKNHQKETSQTVTSRNFDPTNFLKR"
                     /name="hypothetical protein"
     gene            complement(5061..>5552)
                     /locus_tag="LLE91_RS16155"
                     /old_locus_tag="LLE91_16155"
                     /pseudo=""
     CDS             complement(5061..>5552)
                     /locus_tag="LLE91_RS16155"
                     /old_locus_tag="LLE91_16155"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002311815.1"
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006270 - DNA replication initiation
                     [Evidence IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /name="replication initiation protein"
     gene            complement(5607..6287)
                     /locus_tag="LLE91_RS16160"
                     /old_locus_tag="LLE91_16160"
     CDS             complement(5607..6287)
                     /locus_tag="LLE91_RS16160"
                     /old_locus_tag="LLE91_16160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="WP_001015311.1"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            complement(6421..7425)
                     /locus_tag="LLE91_RS16165"
                     /old_locus_tag="LLE91_16165"
     CDS             complement(6421..7425)
                     /locus_tag="LLE91_RS16165"
                     /old_locus_tag="LLE91_16165"
                     /EC_number="3.5.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002344006.1"
                     /GO_function="GO:0097367 - carbohydrate derivative binding
                     [Evidence IEA]; GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SIS domain-containing protein"
                     /protein_id="WP_016173088.1"
                     /translation="MLKFNEQKQIDDIQGALDLRPEVEKIIDSVWEKGFDNIYYLGIGG
                     TYASAMQAVTYINGKSNLPAYVQHAAEYYTTGNKRLTKDSIVVLSSVTGTTQEVVKAVD
                     EIKTVGATLIGFIDTEHSPLAEKCDYVITYPAPGTEQIKFFMVADRLMKNNGEFDDYED
                     YYQELEGHLAKGLVEAEKQADAFGLEFAEKHRHDAMHYFIGAGNQWGAVYSYAMCYWEE
                     QSWLRSKSIHAAEFLHGTLEIVDETTPVTLFLGEDEQRPLAERVKNLLPRICGNYTFID
                     SKDYAVEGISEKYRGRVLSFLLMHCVTQRIDAHVEKLNCHPLEIRRYYRQFDY"
                     /name="SIS domain-containing protein"
     gene            complement(7449..8498)
                     /locus_tag="LLE91_RS16170"
                     /old_locus_tag="LLE91_16170"
     CDS             complement(7449..8498)
                     /locus_tag="LLE91_RS16170"
                     /old_locus_tag="LLE91_16170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016173089.1"
                     /GO_function="GO:0097367 - carbohydrate derivative binding
                     [Evidence IEA]"
                     /GO_process="GO:1901135 - carbohydrate derivative metabolic
                     process [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SIS domain-containing protein"
                     /protein_id="WP_016173089.1"
                     /translation="METMLDYINEEEATLQNILADFSLKKVSGYEKINNLLILATGSSY
                     NACLAAKVTLEKFADIAITIEEPYNFNHYGRISNSVDAVLAVSQSGKSASTIDAIAKLK
                     KEGLFTLALTSDVSSPIATVVDEVIDLEMGIEKVGFVTKGYVSSVLQLFLLGLTIGYNK
                     QTLSQRQLDYYQRELKKVIAAIPDTIEKTNNFFTVHEAIFKLGTRFIAIGYGPNWGTAK
                     EFETKFTETVRKPSQGFELEAYMHGPYLEADSEHILFFIETKSVNEARSQSLKNYMNPY
                     VGTTITVTTANTKNETELGLAIECDELISSLLLVIPFQILAYKIATAKGIDLSQRIFDD
                     FDQVLKSKV"
                     /name="SIS domain-containing protein"
     gene            complement(8511..9332)
                     /locus_tag="LLE91_RS16175"
                     /old_locus_tag="LLE91_16175"
     CDS             complement(8511..9332)
                     /locus_tag="LLE91_RS16175"
                     /old_locus_tag="LLE91_16175"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010760606.1"
                     /GO_component="GO:1902495 - transmembrane transporter
                     complex [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]; GO:0009401 - phosphoenolpyruvate-dependent sugar
                     phosphotransferase system [Evidence IEA]; GO:0016310 -
                     phosphorylation [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS system mannose/fructose/sorbose family
                     transporter subunit IID"
                     /protein_id="WP_016173090.1"
                     /translation="MTKTSNTDLKITKKDLSKVFWRSFQMEFSWNYERQMNMAYAYAMI
                     PILKKLYQTKEQMADALKRHLEFFNTTPHIVTLILGINAAMEEENVNDPDFDTSAIDSI
                     KTSLMGPLAGIGDSFFWGTLRLIATGVGTSLALQGNILGPILFLLIFNIPHILFRYLAT
                     SWGYKLGTGFLKKIQENGMMESLTLGASIIGLMVVGGMTATMIDINLPMKIGSGENAVT
                     VQSIFDDIVPKILCLGVFGAVFYLLKKEVKPLTILLGLAVVGILGSLVGIF"
                     /name="PTS system mannose/fructose/sorbose family
                     transporter subunit IID"
     gene            complement(9316..10107)
                     /locus_tag="LLE91_RS16180"
                     /old_locus_tag="LLE91_16180"
     CDS             complement(9316..10107)
                     /locus_tag="LLE91_RS16180"
                     /old_locus_tag="LLE91_16180"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002340241.1"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0034219 - carbohydrate transmembrane
                     transport [Evidence IEA]; GO:0009401 -
                     phosphoenolpyruvate-dependent sugar phosphotransferase
                     system [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="WP_016173091.1"
                     /translation="MIVQAILLGIVAFIAQSEYALGTSLLSRPIVTGLFTGIVLGDIKT
                     GIIMGATLELAFIGSFSVGASIPPDVVTGGILGTAFAITAGAGTETALLLGLPIATLTL
                     ILKNIYLGLLIPIMNHKADDYAAEGNYKGVERMHLCAGFGLSLMLGLIVMISFMVGSKT
                     IGNLLAMIPEFVQHGLSVATGLIPALGFAMLARLLINKKVAPYFFLGFALAAYLEIPVT
                     GIAIFGAIVAVVVVNIMNVRSNQAPQVQATTGEVVDDDEDF"
                     /name="PTS sugar transporter subunit IIC"
     gene            complement(10126..10596)
                     /locus_tag="LLE91_RS16185"
                     /old_locus_tag="LLE91_16185"
     CDS             complement(10126..10596)
                     /locus_tag="LLE91_RS16185"
                     /old_locus_tag="LLE91_16185"
                     /EC_number="2.7.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016629538.1"
                     /GO_function="GO:0008982 -
                     protein-N(PI)-phosphohistidine-sugar phosphotransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]; GO:0009401 - phosphoenolpyruvate-dependent sugar
                     phosphotransferase system [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="WP_016173092.1"
                     /translation="MIILTRVDHRLLHGQVAFSWTQSLGADCILIANDDVPNNEVRKTT
                     IKLAKPQGVKLVIKNIADSIAALQSGVTDKYKLFIVVESVGDAYKLAEAYPEIKKINLG
                     GTKVKEGTRSIGKAVNVLPEEEELLKKLVDQGVEVEIRQVPNDKKVNVTEVL"
                     /name="PTS sugar transporter subunit IIB"
     gene            complement(10615..11034)
                     /locus_tag="LLE91_RS16190"
                     /old_locus_tag="LLE91_16190"
     CDS             complement(10615..11034)
                     /locus_tag="LLE91_RS16190"
                     /old_locus_tag="LLE91_16190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016173093.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_016173093.1"
                     /translation="MERKMILASHGKFASGILSSLELICGKNDNITTLDCYITEDFDLT
                     KAVDELMHQNEGTEVVVVTDLFGGSVNNEFLRYINREHFYLVAGMNLPFLIEFATQFAF
                     VPELKTTITSVLDSSKEAIQFCNLTYQTTVAEEDF"
                     /name="hypothetical protein"
     gene            complement(11109..13877)
                     /locus_tag="LLE91_RS16195"
                     /old_locus_tag="LLE91_16195"
     CDS             complement(11109..13877)
                     /locus_tag="LLE91_RS16195"
                     /old_locus_tag="LLE91_16195"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016173094.1"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA];
                     GO:0008134 - transcription factor binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-54-dependent transcriptional regulator"
                     /protein_id="WP_016173094.1"
                     /translation="MKEELVTYLENQTAFIDLHHLSEVFTAQKLAEIFEVKRNTISHYL
                     NQLNEAGILVKINSRPVYYFHKEAFEKEFFFLRDNFYQSSEEILKEQPLFEQQKDLFSL
                     LIGHDKSLTRAVEQIKTALYYPDNGLPTLITGESGTGKSFLVRLIHKYCLENELIKEDA
                     PLITLNCAQYANNPELLTSNLFGHVKGAYTGADSDKVGAFEAADGGILFLDEVHRLNAE
                     GQEKLFTYLDQGIIYPMGATNQPIKVKTRLFFATTEDLESSFLTTFMRRIPIQVTLPPI
                     NARSRNERLELVYSFLLSEVRKIKRPLKVSGQVLTLLTSSSFKGNIGELKNTVKVTVAK
                     AFAEQKQAAEIKVTIYQLPEKLLLPATENLQTVLQKDTVITENTTITQLLEKNHPQQQR
                     VIATFDRIITEFSKQQQLTACEEQLKQEVETLFDFLLFETDRQQKQEMLIYLTQYIRDT
                     FKQMESAYQIKFNGNAVYAISYYLFQRGAGKWYPEDVAILGLIKELEQQVATKYAASYQ
                     YVKRLLELCQPKLDLEISEMDCILLTIYLNRADWQKELGIPRGIIVAHGYATASSIANV
                     ANRFLAKDIFASFDMPLDVTPQQIAEEILDYSENHDVSNGLVILVDMGSLKEIYQFFPK
                     QITAPVVIMNNVTTPLAIAMGENLQKALPLAEMIETAAQQAPLDWEIIYPAENKMKALI
                     TTCLTGIGTATHISQLLEKSLPATVELKIFPYEYDVLKEQKKNETIFSMYDVLGIIGTS
                     DPEIADIPYLSLEELISGDENQLLSEWLSTCLSPLENATFNTNVIRNFSLEKVIDSVTI
                     LDTEKVMGEIEIFMRELEANSGLVISNAKKLALYVHVSCLIERLIRNIPIDTYAGYELL
                     YQCQKTALVAIKNAFSVIENDYSVKIPDSEIAYIYDIVYQNTDNMPIDEDF"
                     /name="sigma-54-dependent transcriptional regulator"
     gene            complement(14025..14693)
                     /locus_tag="LLE91_RS16200"
                     /old_locus_tag="LLE91_16200"
     CDS             complement(14025..14693)
                     /locus_tag="LLE91_RS16200"
                     /old_locus_tag="LLE91_16200"
                     /inference="COORDINATES: protein motif:HMM:NF023568.3"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_322746435.1"
                     /translation="MIDTVRDFILYLKLCNRTIISDFIQTKYPTLPLYLFGHSFGSIIA
                     RNYLQKNDDRIAKVALTGTANYVPVVPLGIAAGKLFLRFNEKDKQNKLLNWLSGNMGVE
                     HDWLSNNPVNNLQCQQDEKMVPIYPVRSLLTIWEGDYQLKNYAAFQCHNPQLPILSVVG
                     AEDVKITGGKKGLADTIATLNKIGYQNVRSVEMPGMKHEVLNEYQKEDVYDLLLQFFNE
                     "
                     /name="alpha/beta hydrolase"
     gene            complement(14694..15374)
                     /locus_tag="LLE91_RS16205"
                     /old_locus_tag="LLE91_16205"
     CDS             complement(14694..15374)
                     /locus_tag="LLE91_RS16205"
                     /old_locus_tag="LLE91_16205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="WP_001015311.1"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            complement(15412..15576)
                     /locus_tag="LLE91_RS16210"
                     /old_locus_tag="LLE91_16210"
     CDS             complement(15412..15576)
                     /locus_tag="LLE91_RS16210"
                     /old_locus_tag="LLE91_16210"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002326887.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_164450253.1"
                     /translation="MFKKTKSLESGKKKIDLKIISSGYFKDFIVIDTKWNKKDIENMVL
                     LQSFKSTIK"
                     /name="hypothetical protein"
     gene            15730..15993
                     /locus_tag="LLE91_RS16215"
                     /old_locus_tag="LLE91_16215"
     CDS             15730..15993
                     /locus_tag="LLE91_RS16215"
                     /old_locus_tag="LLE91_16215"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002329851.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002287514.1"
                     /translation="MEMLPIKKWGNSNGLRLPKYIMEYLGIHTEDKVKIIQEEVNGQKR
                     LIIEAANIENELTIEQLFENYTDERNHVTIQNLGEAVGNEKW"
                     /name="hypothetical protein"
     gene            15987..16337
                     /locus_tag="LLE91_RS16220"
                     /old_locus_tag="LLE91_16220"
     CDS             15987..16337
                     /locus_tag="LLE91_RS16220"
                     /old_locus_tag="LLE91_16220"
                     /EC_number="3.1.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016610020.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003723 - RNA binding [Evidence IEA]; GO:0004521 - RNA
                     endonuclease activity [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system PemK/MazF family
                     toxin"
                     /protein_id="WP_002321032.1"
                     /translation="MVRKPRQGDILLLNTAPRSGHEQTGKRPYIVLSHDIIADYSNVVT
                     VAPISSTTRNYPLYVNINSEYEMKTTGKVLLDQLTTIDYEARECIFLEKAHDSLVEELL
                     MKVRTVFQKVSK"
                     /name="type II toxin-antitoxin system PemK/MazF family
                     toxin"
     gene            complement(16361..16975)
                     /locus_tag="LLE91_RS16225"
                     /old_locus_tag="LLE91_16225"
     CDS             complement(16361..16975)
                     /locus_tag="LLE91_RS16225"
                     /old_locus_tag="LLE91_16225"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001261742.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_010729795.1"
                     /translation="MRVAYIRVSSIDQNEQRQIEEMKKFGAERIFIEKQSGATITHRLV
                     FQEALDFVRDQDIFIVEAIDRLGRNYDEIIASVNYLKKKNVQLIITSLPIMAEAIGNPL
                     LDKFIKDLIIQILAMIAEQERTESKRRQAQGIKIAKANGVYKGRPKLYSANAKDPQRRL
                     VYKNIVEDLKKGVAIAKIAKDYNVTRQTVYRIKKDSMVNHE"
                     /name="recombinase family protein"
     gene            17289..17711
                     /locus_tag="LLE91_RS16230"
                     /old_locus_tag="LLE91_16230"
     CDS             17289..17711
                     /locus_tag="LLE91_RS16230"
                     /old_locus_tag="LLE91_16230"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002303116.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002288787.1"
                     /translation="MKNKFILSLGILTIGISVTGTTIPTFADSTNEPTTVVDNNQELTP
                     LDRNGIAIGNPTNDLTVTENYLIVSPLLARAASKTIRVTGTMIFDKVGWPSRPPQSRNW
                     KEKRNGYWYYGKLYLQSYKSAGNNWIATYSGTLTRK"
                     /name="hypothetical protein"
     gene            17721..17924
                     /locus_tag="LLE91_RS16235"
                     /old_locus_tag="LLE91_16235"
     CDS             17721..17924
                     /locus_tag="LLE91_RS16235"
                     /old_locus_tag="LLE91_16235"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016631607.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002299573.1"
                     /translation="MPEFVNTPNFYQDSDILSKINLPKEESALQVQRTLQETQKIQKSI
                     SNLEDSEEKRKKRDQKTYQKEK"
                     /name="hypothetical protein"
     gene            18135..18719
                     /locus_tag="LLE91_RS16240"
                     /old_locus_tag="LLE91_16240"
     CDS             18135..18719
                     /locus_tag="LLE91_RS16240"
                     /old_locus_tag="LLE91_16240"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007207927.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_002299575.1"
                     /translation="MKIGYARVSTGLQNLDLQEDSLNKFGCEKIFTDHMSGAKSNRPGL
                     EMAIDFVRSGDTLVVWRLDRLGRNMEDLISIVNRLNERGVSFHSIQENITMDKSSSTGQ
                     LMFHLFAAFAEFERNLILERSAAGRAAARARGRFGGRPEKLSEQDLELLKTLVDSGTPI
                     KTIAERWNVSRTTIYRYLAKMEEKNGKTNSH"
                     /name="recombinase family protein"
     gene            19090..20415
                     /locus_tag="LLE91_RS16245"
                     /old_locus_tag="LLE91_16245"
     CDS             19090..20415
                     /locus_tag="LLE91_RS16245"
                     /old_locus_tag="LLE91_16245"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002335330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Y-family DNA polymerase"
                     /protein_id="WP_002303115.1"
                     /translation="MMDYSKEPVNDYFLIDMKSFYASVECIERNLDPLTTELVVMSRSD
                     NTGSGLILASSPEAKKRYGITNVSRPRDLPQPFPKTLHVVPPRMNLYIKRNMQVNNIFR
                     RYVADEDLLIYSIDESILKVTKSLNLFTTEETRSQRRKKLAQMIQERIKEELGLIATVG
                     VGDNPLLAKLALDNEAKHNEGFIAEWTYENVPEKVWNIPEMTDFWGIGSRMKKRLNQMG
                     ILSIRDLANWNPYTIKNRLGVIGLQLYFHANGIDRTDIAIPPEPTKEKSYGNSQVLPRD
                     YTRRNEIELVVKEMAEQVAIRIRQHNCKTGCVHLNIGTSILETRPGFSHQMKIPITDNT
                     KELQNYCLFLFDKYYEGQEVRHVGITYSKLVYTDSLQLDLFSDPQKQINEENLDKIIDK
                     IRQKYGFTSIVHASSMLESARSITRSTLVGGHAGGNGGIKND"
                     /name="Y-family DNA polymerase"
     gene            20408..20758
                     /locus_tag="LLE91_RS16250"
                     /old_locus_tag="LLE91_16250"
     CDS             20408..20758
                     /locus_tag="LLE91_RS16250"
                     /old_locus_tag="LLE91_16250"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002359653.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002303114.1"
                     /translation="MIDYNDRGRLKWAGFYLSDHTEEIDADNEQRTSQNLAKEQMTTEE
                     IAEVLNAAVIKNRSVSIQKEERNAEGYYPEDIVGKILGSDELGIYVGKDKIHYDEIRHI
                     EFYQDNKWSRLE"
                     /name="hypothetical protein"
     gene            20755..20934
                     /locus_tag="LLE91_RS16255"
                     /old_locus_tag="LLE91_16255"
     CDS             20755..20934
                     /locus_tag="LLE91_RS16255"
                     /old_locus_tag="LLE91_16255"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001021554.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001021554.1"
                     /translation="MNIIQQYELKYITFDQLSEEIWGYGQRLINEVGVERFSFYVEAAA
                     GYHNFRFYIFPLYI"
                     /name="hypothetical protein"
     gene            21070..21360
                     /locus_tag="LLE91_RS16260"
                     /old_locus_tag="LLE91_16260"
     CDS             21070..21360
                     /locus_tag="LLE91_RS16260"
                     /old_locus_tag="LLE91_16260"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000026576.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000026576.1"
                     /translation="MSINTFVYSHPINVYIIKNLGITVEQFCELYAYPQGTVASWITRQ
                     RRIKSLPASFVYDLSLASSLNMSDVYEKLLSLEKEYDSFKIKHDKKIKKHI"
                     /name="hypothetical protein"
     gene            21728..22516
                     /locus_tag="LLE91_RS16265"
                     /old_locus_tag="LLE91_16265"
     CDS             21728..22516
                     /locus_tag="LLE91_RS16265"
                     /old_locus_tag="LLE91_16265"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002302898.1"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA];
                     GO:0016887 - ATP hydrolysis activity [Evidence IEA]"
                     /GO_process="GO:0007059 - chromosome segregation [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="WP_002302898.1"
                     /translation="MARILSVANQKGGVSKTTTSVNLAACLKFVYGKNVLLVDIDPQGN
                     ATDNVGFDIDGTNQPTIYEVLKGEADITDAILDYKGIDVLPADIALSSAEREFTQVGSE
                     HRLKRVLQPIKDNYDYIIIDCPPSLGMLTVNAFTVSDEIIIPVEAAYFSLKGLIKLSET
                     IETVKEYTNDKLEVRGVLFTKYNKRYNISKEMTTAATEISRVIGAKIFKTYIRRTITVD
                     EAQAAGSDLINFNKPSTAEDDYKAFTEEYLKEVGDFDGRR"
                     /name="AAA family ATPase"
     gene            22503..22829
                     /locus_tag="LLE91_RS16270"
                     /old_locus_tag="LLE91_16270"
     CDS             22503..22829
                     /locus_tag="LLE91_RS16270"
                     /old_locus_tag="LLE91_16270"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002299230.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002299230.1"
                     /translation="MAEDNRSQAAVSRLLGNKNKKNYKPKEVEEIELTKKNISKVIKDQ
                     GSSVRTADSIRINPILMSALKYWTTIAESDKSKPDVIEDALLKSIPEEYLIEGYKLAKK
                     QNKI"
                     /name="hypothetical protein"
     Typing          2..1041
                     /name="rep_cluster_889"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.904"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(5062..5552)
                     /name="rep_cluster_1763"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="89.0"
                     /evalue="0.0"
ORIGIN
        1 atgaatgatt ttaattatta caaatcaaaa gaaatttatc gtgaaaaata ttatcaaatg
       61 cctaaggtat tttttactaa cgaaaaatac atggatcttt caaatgatgc aaaaattgct
      121 tatatgctac ttaaagatcg atttgattat tcagtcaaaa ataactgggt agattctgat
      181 gataatatat tcttcatatt cacagttgaa gaattaatga aattgttaca atgccgcgaa
      241 ggtaaagtat ctaagatcaa aaaagaatta gaaaaagcag gtcttctgaa acagaagaga
      301 ggaagagtaa ataaacgtga tggtaagatt gaatctatgc ctaatttatt gtacttaggc
      361 aagccagaag ttacgaatca agacgtcttt aaaatcatgg aagaggaaga caatactgat
      421 tccaccgtaa ttgcgaaaat cgcaaatacg gcaaaaccgc gaaaaatcaa tgattctacc
      481 gtaattgcga aaatcgcaaa tacggcaaaa tccagtcata tcaaggactc aaccgtaatt
      541 gcgaaaatcg cagacaatct attctattct aattctatag acactaatag acacataata
      601 gacactgaaa ctgaccagtt acaaaatcaa gttttgctag ataacttcgt cgacatcatg
      661 caagaggaca gtataaatac atttgtacca gaaaatgtat taaacttgat aaaaacattt
      721 tcttcaagtt acagtgaagc tcaacaaacc gtccaaacta ttcataatgc aaagaaaaaa
      781 gctgaagaat tagagcaaac tattgtcgtt tatgaagaac tggaatctta tggaattgat
      841 gctgacaaag gattatatat gactttactg aaagcttatc aaaaacaaaa aactgaaaaa
      901 gtaaacaatt tgcagaatct aattttcgtt tatgtaaaaa attggtttgt cgaaaaagct
      961 attgcggcaa agcttgcaaa cgaacaaaga gaaacattta acgaattacc aacagttagt
     1021 acggaaaatt ggttagagta gttgataaaa agcaattact ataaaaatga tcaattttaa
     1081 attagaactt ttttatgatt ttaattttat tacaaatatt acaaataaat agttagtatt
     1141 ccggagtttt tagattaaaa gtttatgaaa acaatcacaa tcgtaggttt taaattcata
     1201 atcgttagat attttagtta tttttcactc aaaaaaatag ggaactagtg tttgcatatg
     1261 tgcttttttg agttataata attcatgaag agaggtaatt cacttatttc cccaagctga
     1321 aaagcctgat attacttctt ttcaggcagt gctgctaata ttcaattaca cttttttgta
     1381 tatttttagt tgttttaaat ttaattgtct gctatgcttg tgatgaattg attttcgttc
     1441 tgcacttttg gacgataaat ttggacaatt gaaaatacaa aaaaaagaaa ggccctgtga
     1501 gactcggaag gctggtaacc ttcgtcgacg tccacaggtg gcattaagat cactccctta
     1561 atgcgtttac ctttcagtgt tacggtatta cccgtaacgg atttagggtt ctgttgcaaa
     1621 gttttaaata aagaataaaa tcccttacgg tatctatgat ttaagctggg attcccaata
     1681 ataccttgat ttcagtacag accgaaaacc cgaagagagt gccttctttt cgggttttct
     1741 tatataatcc tcgaatggct tccatgcctt taatcgtggt agaggcagtg cgtaaacttc
     1801 gatagaattt attgcgtctc tttactggac gatggtcttg ttcaatcaaa ttattcaggt
     1861 atttaatggt acgatgttct gtcccttgat aaaagccgta ttcttttagt ttcttaaagg
     1921 cacttgtaat agagggggct ttatctgtga ctacaacctt cggttcatca aactgcttca
     1981 ctaaccgctt aagaaaagca taggctgctt gtgtgtcccg ttttttacgt aaccaaatat
     2041 ccaaggttaa accatctgca tcgatggctc gatacaaata atgccatttt cctttaattt
     2101 tgatgtacgt ttcatccatt ttccatgaat aaaaggattt tttatttttc tttttccaaa
     2161 tttgatagag tagtttgcca tattcttgca cccaacgata aatcgtcgta tgagaaacgt
     2221 taatgccacg atcatataag atttcttgaa cttcacgata gctaaggtta taacgaagat
     2281 agtagcccac ggctacaata atcacatcct gctgaaattg ctttccttta aaatgattca
     2341 tcgtcattcc tcctgctatc tttttctatt attctacctt atttgatagt agatttaaaa
     2401 ctttgcaaca gaaccaaaga aaatctaact tttttcaaac cacgatcttt catacgagcg
     2461 cataatgcaa aaaataaatc catctgctta gcattgaaat ttttcagcgg tactaaattc
     2521 aattcatttt gatatttgac tgttaattcc gttttttcat ccattccttt cttcccccct
     2581 tacaaataaa taataacctt taacaaccaa ctcgtaaata ggttggttgt tattatacaa
     2641 aaggatatta gtactcagat aaaaagttgt tagtactcag ataaaaagtt gttagtactc
     2701 agataaaaag ttgttagtac tcagataaaa agttgttagt actcagataa aaagttgtta
     2761 gtacccttct gtatccgttg ggagagtaag gctcaactgc cccctaaaaa gggttctaaa
     2821 aaatctttaa aaaataaata aaataaacgc gcgcgcgcga gcaaaatttc ccgccaaaaa
     2881 atcacccact ttttaaaata aacaggttcg cgcatgatat taaactgcca atctagctcc
     2941 ctatggtcgc tgtaagaagg agtgatcgct acgctctcac attttacttg cagcagtcgc
     3001 ctttaggctc cttcgccaaa aataattcat tagggactcc tttgtggcgt cctgagagct
     3061 cgtctaagcc gttctaagac aagattcgat aaaaactatg tccttcgttc taaagcgcct
     3121 tacaggcggt cagggcaagc cctaacaacc ccaaggcaat aaaaaactta ggcttatttt
     3181 tgctttttta ttgtataatt gattgtcgcc tatccgacag tcttgcgact ggaaggaggt
     3241 gtgtttcgtg ttcactaact ttatttgctc ccttcttgtt gggcttttaa gcgctttgtt
     3301 cagttactgg ttgaataacc gaaacaagaa gtaaaattaa ttaaggcgac tcagcccaca
     3361 aaaaaagccc cagagaatcc gacctctctg gggctttcgt gtgtttcgtg ttcacttatt
     3421 tgcaatcaaa ttataacaga aataaatatt tatttcaaaa atatcctaca aaagtctaaa
     3481 atccgtaatt atttcttata tgcaacattt acaaataaag tcgctctgag agctcgtatt
     3541 tttcgattta agacgtttta tttagttttt ggtgtatttc attggtccaa gctaaaaaac
     3601 tcttagaagc gattttagag ccatttaaac ccacttaatt atattctcca tgaaattcgc
     3661 tccatgcgtc aaaagctgcg tctgaaattc cgccgtcttc gttcactagt tgcattaatt
     3721 tttccaacga tcgttttctt tcgggtgtca tatttttata ttccaacaat ttttcgtctg
     3781 ttaaatcgaa cttgattgct tgaattgctt gctctaattt ttctaagttt tgaaaatatt
     3841 cgtaaggaaa tttttccatt ttttctttct ccagtctcac aatttttcta gaaataaaat
     3901 cacttctttg ccgtctatac tctcaaaaaa aatgtcgttt gaaaaactaa ataaattttt
     3961 gatcgtgcat ttttaaattt ggttatcgat tacacgtgca gcactccccc ccgaatttta
     4021 aagagcataa ggaaacgtgt acccactttc taaaaaaagt gggtagatag gctgtgccta
     4081 tcacgtttct cagaaaaaaa tttgatatca ctttttcgcc atcgtgggta gcttatgtat
     4141 agcattttgg caaaaaacag ctatacaaat actatatttg tatggtatac ataaattata
     4201 cgataatgca aaaggagatt ttttatggac attttagttc ggaatattga tccaaagttt
     4261 gttgcaacaa tagacaaacg ttgccaagaa ctcacgaata aaacaggaga aaaatggagt
     4321 cgaaataaat atctaaaagt tttaatcgaa agtgattttg accgtcaact tacgacttac
     4381 aaaaaagacc aattcgattt attgctcgat aaatttattg ctatccaaac agaaaatact
     4441 caaatattaa gcgagtatgt ctacacaaat aatcaaatca ttgaaatgct tatcggagga
     4501 atataacatg agaaaaactt ctgtccaaaa acatgttact ttgtacccta gtcatgttga
     4561 cgttttagat tccatcatcg aaaaaaatcc agatatcaat aactactcgg aagccattcg
     4621 ctttttatgt atgagttatg aacccgatac caacacgacc actaccagca atcaggcaaa
     4681 actaaatgct atgggaaaag aaatttccat catgactgaa atcatcgcag aatttgctga
     4741 tttatatcta aaagatacag gcgttcttat tggcacaaat tctaaagtat atcaagaagt
     4801 gaaagaaaaa atcgaagcta aactaaatcc atcaaatcga aatcgaccaa agaatcatca
     4861 aaaagaaacc agtcaaacag tcacttctag aaatttcgac ccaacaaatt ttctaaaacg
     4921 ataaaaaaca gataggagtt attcctatct gttttttatt tagaagcccc atacaatatg
     4981 ctagaatgta ctagcaatct tagtcggttg taagggactt gtctacttgc ttaatgtaag
     5041 gggggcgagt tcttttttat ttattcttct aaccagttac gcagagaaat ctttggcaaa
     5101 tctgacgtta ggcttgaaaa agtaaattct aatttggcga ttttattgcc cttttttgct
     5161 tttatttttg tgactttaag atcattgaag tattttttta gttctcgtaa tgcaggattt
     5221 aatacttttt gatcaatgtt acccatttga tagtattctg ggatatccat taagctccta
     5281 aactcttcaa tacgaactac ataataacca gtagaacggt actgcataag cagtcggaat
     5341 agagtttttg catacgtaga acgcaacgac gtgaaagcag ataattcaaa tctactaaat
     5401 tcagctgtta aaccattaat aatatattct aggtccggat taacactgac ttcaacaaac
     5461 ttttttgttt tattgatttc aaaaccagta aacaaaacaa agtagcgaat agaatcctca
     5521 tcttcagtac ggtaagtaag attaagcata tcggttctgt tgcaaagttt taaataaaga
     5581 ataaaatccc ttacggtatc tatgatttaa gctgggattc ccaataatac cttgatttca
     5641 gtacagaccg aaaacccgaa gagagtgcct tcttttcggg ttttcttata taatcctcga
     5701 atggcttcca tgcctttaat cgtggtagag gcagtgcgta aacttcgata gaatttattg
     5761 cgtctcttta ctggacgatg gtcttgttca atcaaattat tcaggtattt aatggtacga
     5821 tgttctgtcc cttgataaaa gccgtattct tttagtttct taaaggcact tgtaatagag
     5881 ggggctttat ctgtgactac aaccttcggt tcatcaaact gcttcactaa ccgcttaaga
     5941 aaagcatagg ctgcttgtgt gtcccgtttt ttacgtaacc aaatatccaa ggttaaacca
     6001 tctgcatcga tggctcgata caaataatgc cattttcctt taattttgat gtacgtttca
     6061 tccattttcc atgaataaaa ggatttttta tttttctttt tccaaatttg atagagtagt
     6121 ttgccatatt cttgcaccca acgataaatc gtcgtatgag aaacgttaat gccacgatca
     6181 tataagattt cttgaacttc acgatagcta aggttataac gaagatagta gcccacggct
     6241 acaataatca catcctgctg aaattgcttt cctttaaaat gattcatcgt cattcctcct
     6301 gctatctttt tctattattc taccttattt gatagtagat ttaaaacttt gcaacagaac
     6361 ccatgtaccg aaattgtgca aaaaaccttc ccgtcacatg acgagaaggt cttaatcatt
     6421 ttaatagtca aattgacggt agtagcgccg aatttccaat ggatgacaat ttaatttttc
     6481 tacatgggca tcaatccgtt gggtcacaca atgcattaat aagaatgata atacacgtcc
     6541 acgatatttt tcactgattc cttccacagc ataatctttt gagtcaatga aagtatagtt
     6601 gccacaaata cgcggtaata agtttttcac gcgctctgct aagggacgtt gttcatcttc
     6661 tcctaagaaa agtgtaaccg gtgtcgtttc atcgacaatt tctaatgtac catgtaaaaa
     6721 ttcagcagcg tggattgatt ttgaacgcaa ccagctttgt tcttcccaat aacacatcgc
     6781 atatgagtag acagcgcccc attgattccc cgccccaatg aaataatgca tcgcatcatg
     6841 acggtgtttt tctgcaaatt ccaaaccaaa agcatctgct tgtttttccg cttcaactaa
     6901 acctttggct aaatgtcctt ctagttcttg ataataatct tcatagtcgt caaattcacc
     6961 attatttttc attagacggt ctgccaccat aaagaatttg atttgttctg ttcccggagc
     7021 tggataggta ataacataat cacatttttc agctaagggg ctgtgttcag tgtcgataaa
     7081 gccaattaaa gttgccccta ctgttttaat ttcatccact gctttgacca cttcctgggt
     7141 tgtgccagtg acagaagata aaacgacaat tgaatctttg gttaggcgtt tattgccggt
     7201 tgtatagtat tctgctgcat gttgcacgta agcaggcaaa ttacttttac cattgatata
     7261 agttacagcc tgcattgcag atgcataagt tccgccaatt cctaaatagt aaatattgtc
     7321 aaaacctttt tcccacacgc tgtcgataat tttttctact tctgggcgta agtctaatgc
     7381 tccttgaata tcgtcaattt gtttttgttc gttaaatttt aacatttttc cacctctatc
     7441 atttactttt acactttact ttttagtact tgatcaaaat catcaaaaat ccgctggctt
     7501 aaatcaatgc ctttggcagt cgcaatttta tatgccaaaa tttggaaagg aatcactaag
     7561 agtaaagatg aaattaattc gtcacactct atagccaaac ctaactctgt ttcatttttg
     7621 gtattggcag ttgttaccgt aatcgttgtt cctacgtaag gattcatata gttttttaaa
     7681 ctttgggagc gcgcttcatt cacacttttt gtttcaataa agaataaaat atgctcgcta
     7741 tctgcttcta aataagggcc gtgcatgtag gcttctagtt caaaaccttg cgaaggtttg
     7801 cgaaccgttt cagtaaattt tgtttcaaat tcctttgcag ttccccagtt tggaccatag
     7861 ccaatggcga taaaccgtgt gcctagttta aaaatcgctt cgtgaaccgt aaagaaattg
     7921 ttcgtttttt caattgtatc aggaatggct gcgatcactt ttttaagttc acgttgataa
     7981 taatccaact gtctttgact taaagtttgt ttattgtaac caatcgttaa gcctagtaaa
     8041 aacagttgaa gcacactcga cacatagccc tttgttacaa aaccgacttt ttcaattccc
     8101 atttcaagat caattacttc atctactact gtagcaatgg gactagaaac atcactggtt
     8161 aaggctaaag taaataatcc ttcttttttt aatttggcaa tagcgtcaat cgtagacgca
     8221 ctcttgccac tttgagaaac tgccaaaaca gcatccacgc tatttgaaat gcgaccataa
     8281 tgattaaagt tatacggttc ttcaatcgtg atcgcgatat cggcaaattt ttctaaagta
     8341 actttagctg ctaagcaggc attgtaagat gaaccggtgg ctaagattaa cagattgttg
     8401 attttttcat agcctgaaac tttttttaag gaaaaatccg ctaaaatatt ttgcagtgtc
     8461 gcttcttctt cgttgatgta atccaacatc gtttccatcc attacacctc ctagaaaatg
     8521 cctactaatg aacctaagat tcctaccaca gctaagccta aaagaatcgt taatggcttc
     8581 acttcttttt tcaatagata gaaaactgcg ccaaaaacac caagacataa aattttcggc
     8641 acaatatcat caaaaatact ttggacggtg acggcatttt ctcctgaacc aattttcatt
     8701 ggtaagttga tatcaatcat agttgcagtc atgcctccga ccaccatcaa tccaataatc
     8761 gacgcaccta aagttaaact ttccatcatc ccgttttctt gaattttctt taaaaagccc
     8821 gtccctaatt tataccccca gctggttgcc aagtagcgga ataaaatatg cggaatattg
     8881 aaaatcaaca agaataaaat cggacctaaa atatttcctt gtaatgccag agaagttcct
     8941 acacctgtgg caatcagacg taatgtgccc cagaaaaatg aatccccaat ccccgccaat
     9001 ggacccatca atgatgtttt aatactgtca atggcagaag tatcaaaatc aggatcatta
     9061 acattttctt cttccatcgc cgcattaatc cccaaaatta aggtcacaat atgtggcgtc
     9121 gtattgaaaa attctaaatg acgtttcagc gcatcggcca tttgttcttt ggtttgatac
     9181 aattttttca aaattgggat catcgcatag gcatatgcca tattcatctg acgctcatag
     9241 ttccaagaaa actccatttg aaacgagcgc caaaatactt tgcttaaatc ctttttagtg
     9301 atttttaaat ccgtattaga agtcttcgtc atcatcaact acctcccctg tagtggcttg
     9361 aacttgtgga gcctggttgc tacgtacatt cataatgttg actacgacaa ctgcgacaat
     9421 cgcaccaaaa atggcaatcc cagtaacagg aatttctaaa taagctgcta atgcaaatcc
     9481 taagaagaag tatggtgcca cctttttatt aattaataaa cgagccaaca tcgcaaaacc
     9541 taaagctgga attaaaccag ttgccaccga taacccgtgt tgtacgaact ctggaatcat
     9601 cgctagcaaa ttcccaatcg ttttacttcc caccataaag gaaatcatca cgattaaccc
     9661 aagcattaaa gataaaccaa agcctgcaca taaatgcatc cgctcaacgc ctttataatt
     9721 tccttcagct gcataatcgt cggctttgtg gttcataatc gggattaaaa gtcccaaata
     9781 aatatttttc aaaatcaaag ttaatgttgc aatcggtaac ccaagtaata acgctgtctc
     9841 ggtgcccgct cctgcggtaa tcgcaaaagc cgttcccaag ataccaccgg tcaccacatc
     9901 aggtggaata gaagcaccca cggaaaatga accaataaat gctagttcaa gagttgcacc
     9961 cataataatg ccggtcttta tatcccctag aacgatcccg gtaaataaac ccgtcacaat
    10021 tggtcgggac aaaagtgaag tccctaatgc atattctgat tgtgcaataa aagcgacaat
    10081 gcctaataaa attgcttgga caatcatttt ttcactacct ttcttttaca aaacttctgt
    10141 aacgttcacc tttttatcat ttggtacttg acgaatttcg acttccacac cttgatcaac
    10201 taattttttc aaaagttctt cttcttcagg taatacattc actgctttac caatgctgcg
    10261 ggtaccttct ttgacttttg tccccccaag attgattttt ttaatctcag gataagcttc
    10321 ggctaatttg taggcatcgc caacagattc aactacaatg aatagtttgt atttatctgt
    10381 cacaccactt tgtaaagcgg caatagaatc agcaatattt ttaattacca atttaacacc
    10441 ttgtggcttg gctaatttaa tcgttgtttt acgaacttcg ttatttggca catcatcatt
    10501 ggcgattaaa atgcaatctg ctcctaaact ttgtgtccaa gaaaatgcaa cttggccgtg
    10561 caataaccgg tggtcaacgc gggttaaaat aatcattttt cttctctcct ctttttaaaa
    10621 atcttcttct gctacagttg tttgatacgt taaattacaa aactgaatgg cttcttttga
    10681 gctgtctaaa acgctcgtaa tcgttgtttt taattccggt acaaatgcaa attgcgttgc
    10741 aaattcaatt agaaatggta aattcatccc ggctactaag taaaaatgct cacgattaat
    10801 gtagcgtaaa aattcgttat tgacgctgcc gccaaataag tctgtcacga cgacgacttc
    10861 tgtcccttca ttttggtgca tcagttcatc gacagcttta gtcaaatcga agtcttctgt
    10921 tatgtaacaa tccaaagtcg ttatattgtc attcttgcca cagattaatt ccaatgagct
    10981 taaaatgccc gaagcaaatt ttccgtggga agctaaaatc atttttcttt ccatttccct
    11041 cacctcattt cctacaccaa aataaaagca agttgcgtgc caactttagt ggcagcaact
    11101 tgcttttatt aaaaatcttc atcaattggc atattgtcag tgttttgata gacaatatca
    11161 taaatatatg caatttcgga atcaggaatc ttgacactgt aatcattttc tatgacacta
    11221 aacgcatttt tgatggcaac taaagctgtt ttttgacact ggtataacaa ttcataacca
    11281 gcataggtat caattggaat attgcgaata aggcgctcaa ttaaacaact gacgtgaacg
    11341 tacagcgcca actttttggc attgctgata acaagtccgc tattggcttc tagctcccgc
    11401 ataaagattt caatttctcc cattactttt tcagtatcta aaatcgtcac ggaatcaatg
    11461 actttttcta aagaaaaatt gcggataaca ttggtgttaa acgtcgcatt ttctagaggg
    11521 gacaaacaag tacttaacca ttcggataat aactgatttt catcaccaga aattaactct
    11581 tctaaagata aataaggaat atctgcaatc tctgggtcag aagttccgat aatgcctaaa
    11641 acatcataca tggaaaaaat tgtttcattt ttcttttgtt cttttaatac gtcatattcg
    11701 taaggaaaaa ttttcagttc tactgtggca ggtaaacttt tttctaacag ctgactgata
    11761 tgcgtcgctg tcccaattcc tgttaaacaa gtggttatta aggccttcat tttattttcc
    11821 gccggataaa ttatttccca atccaacggt gcttgttgcg cagctgtctc aatcatttcc
    11881 gctaatggta atgctttttg taaattttct cccatcgcaa tggctaaagg cgtcgtgaca
    11941 ttattcataa taaccacagg cgcagtaatt tgttttggga aaaactgata aatttctttt
    12001 aatgacccca tatctactaa aatgactaaa ccattggaaa catcatggtt ctcactgtaa
    12061 tccaaaattt cttcagcaat ttgctgcggg gtgacatcta gtggcatatc aaaagaagcg
    12121 aagatatctt ttgctaaaaa acgattcgca acgtttgcaa tactactggc cgtggcataa
    12181 ccatgagcaa caataatacc tctggggata cccaattctt tttgccaatc tgcccgattt
    12241 aaataaatcg tcagcaaaat gcagtccatc tccgaaattt ccaaatccaa ttttggttgg
    12301 cacaattcca aaagacgttt gacatattga tagctcgctg cgtatttggt tgctacttgc
    12361 tgttctaact ctttaattaa ccctaaaatt gccacatctt ctggatacca cttgcccgct
    12421 cctcgttgga ataaatagta actaatcgca taaaccgcat tgccgttaaa tttgatttga
    12481 taggcacttt ccatttgttt aaaagtatcc ctgatatatt gggttaaata aatcagcatc
    12541 tcttgttttt gctggcgatc agtttcaaaa agtaaaaaat caaatagtgt ttcaacttct
    12601 tgttttaatt gctcttcaca agctgtcagc tgttgctgtt tagaaaactc ggtgataatc
    12661 cggtcaaaag tcgcaatcac ccgttgttgt tgaggatgat ttttttctaa aagttgggta
    12721 atcgtcgtat tttccgtgat tactgtatct ttttggagca cggtttgaag attttctgtt
    12781 gccggtaata gtaatttttc cggtaactga taaattgtaa ctttaatctc tgcggcttgc
    12841 ttttgttcgg caaaagcttt cgctacggtg accttgaccg tatttttcaa ctctccaata
    12901 ttgcctttaa agctgctact ggtaagcaga gttaagactt gaccactaac ttttagtggt
    12961 cgtttaattt ttcgtacttc acttaataaa aatgaataaa ccagttccaa gcgctcattg
    13021 cgactgcggg cattaatcgg tggaagtgtc acttgaatgg gaatccggcg cataaaagtc
    13081 gttaaaaaac tactttccaa atcttctgtc gtggcaaaaa acaagcgcgt tttcactttg
    13141 attggttgat tggtggcccc catgggataa atgatgccct gatccagata agtaaagagc
    13201 ttttcttgtc cttctgcatt caagcgatgt acttcatcta aaaataaaat tcccccatct
    13261 gcggcttcaa aagcaccaac tttgtcactg tcagcaccag tgtaagcacc tttgacatgt
    13321 ccaaacagat tacttgttaa aagttctgga ttattagcgt attgggcgca atttagcgtg
    13381 attaaaggcg catcttcttt aattaattca ttttccagac aatatttatg aatcagacgg
    13441 actaaaaaac ttttgcccgt gccgctttca ccggtgatta aagtcggtaa gccgttatct
    13501 ggataataaa gagcggtttt aatttgttca acggcacgag ttaaactttt atcatggcca
    13561 attaaaagcg aaaataagtc tttttgctgc tcaaataaag gttgctcctt taaaatttct
    13621 tcactgcttt gataaaaatt gtcccgcaag aagaaaaatt ccttttcaaa agcttcctta
    13681 tgaaaataat aaaccggtcg cgaattaatt ttcactaaaa ttcccgcttc atttaattgg
    13741 tttaaatagt ggctaatggt attacgcttc acctcaaaaa tttcggctag tttttgggcg
    13801 gtaaaaactt cacttaaatg gtgaagatca ataaaagctg tctgattttc caaatatgtt
    13861 accaattctt ctttcattat tatccccact tattttcttt actgttgttt taaacgtttt
    13921 cagttttagc cacaatgtac cacaaaaaaa gacagaaact taactagttt cccccttttt
    13981 ttagtgaata ttaataaaac aatatataat gttatgcaac ttctctattc attaaaaaat
    14041 tgcaatagta ggtcatacac atcttctttt tggtactcgt ttaatacttc atgtttcatg
    14101 ccgggcattt ctacactcct aacattttgg tagccaattt tatttagcgt tgctattgta
    14161 tcagccaagc cttttttacc acccgtaatt ttgacatctt ctgcgcctac cacacttaat
    14221 attggtaatt gtggattgtg acattgaaaa gcggcgtagt tttttaactg atagtcccct
    14281 tcccaaattg tcagcaggct acgcactgga taaatcggta ccattttttc atcttgttga
    14341 cattgtaaat tattcaccgg attattactt agccaatcat gttctactcc catgttgcca
    14401 gaaagccaat ttaataattt attttgctta tctttttcat taaagcgtaa aaatagttta
    14461 ccagctgcaa tgcctaaagg aacaacagga acataatttg ctgttccagt taatgcaact
    14521 ttagcgatac ggtcgtcatt tttttgtaaa taattacgcg caatgatcga gccaaaagaa
    14581 tgaccaaata aataaagcgg taatgttggg tatttggttt ggataaagtc gctaataatg
    14641 gttctgttgc aaagttttaa ataaagaata aaatccctta cggtatctat gatttaagct
    14701 gggattccca ataatacctt gatttcagta cagaccgaaa acccgaagag agtgccttct
    14761 tttcgggttt tcttatataa tcctcgaatg gcttccatgc ctttaatcgt ggtagaggca
    14821 gtgcgtaaac ttcgatagaa tttattgcgt ctctttactg gacgatggtc ttgttcaatc
    14881 aaattattca ggtatttaat ggtacgatgt tctgtccctt gataaaagcc gtattctttt
    14941 agtttcttaa aggcacttgt aatagagggg gctttatctg tgactacaac cttcggttca
    15001 tcaaactgct tcactaaccg cttaagaaaa gcataggctg cttgtgtgtc ccgtttttta
    15061 cgtaaccaaa tatccaaggt taaaccatct gcatcgatgg ctcgatacaa ataatgccat
    15121 tttcctttaa ttttgatgta cgtttcatcc attttccatg aataaaagga ttttttattt
    15181 ttctttttcc aaatttgata gagtagtttg ccatattctt gcacccaacg ataaatcgtc
    15241 gtatgagaaa cgttaatgcc acgatcatat aagatttctt gaacttcacg atagctaagg
    15301 ttataacgaa gatagtagcc cacggctaca ataatcacat cctgctgaaa ttgctttcct
    15361 ttaaaatgat tcatcgtcat tcctcctgct atctttttct attattctac cttatttgat
    15421 agtagattta aaactttgca acagaaccat attttctatg tcctttttat tccattttgt
    15481 atcaataact atgaaatctt taaagtatcc agaagagatt atttttagat caattttttt
    15541 cttacctgat tctaaagatt ttgttttctt aaacatatta tgatttcctt tcgactattt
    15601 tcatataaat gttaacatag tttatggatt catggaatgt taatctaatt taatagaaaa
    15661 ggataattaa gtatatacgt tttttcttat gtatgttata ctatgtatat acagaaagag
    15721 gtgtctacta tggaaatgtt acctataaaa aaatggggaa atagtaatgg ccttagattg
    15781 ccaaagtata ttatggaata tcttggaatt catacagaag acaaagtgaa gataatacaa
    15841 gaagaagtaa acggtcagaa gcggctaatt atcgaagcgg ctaatataga aaatgaatta
    15901 acaattgaac agttatttga aaattacact gatgaaagaa atcatgtgac gattcaaaat
    15961 ttaggtgaag cagtaggtaa tgaaaaatgg tgagaaaacc tagacaaggc gatattctat
    16021 tattgaatac agcacctcga tctggacacg aacagacagg taaaagacct tatattgttt
    16081 taagtcatga tattattgcg gattatagta acgttgttac agttgctcca atttctagta
    16141 caactagaaa ctatccgcta tatgtaaata taaactcaga atatgaaatg aagacaacag
    16201 gaaaagtatt attagatcaa ctaacgacaa ttgattatga agccagagag tgtatttttt
    16261 tggaaaaagc gcatgatagt ttagttgagg agttattgat gaaagttaga acagtttttc
    16321 aaaaagtaag caaataaaat agaaacagca gcatgatcaa ctattcgtga ttgaccatgc
    16381 tgtctttttt tattctatat acggtttgtc tcgtaacatt gtagtctttt gcaatcttag
    16441 cgatcgcaac accttttttt agatcctcaa cgatgttttt ataaacaaga cgacgttggg
    16501 gatcttttgc attggcactg tatagcttag gacgtccttt ataaacaccg ttcgcttttg
    16561 caatcttaat gccttgtgcc tgacgtcgtt tagattcggt acgttcttgt tcagcgatca
    16621 tggccaaaat ttgaatgatc aaatctttaa tgaatttatc caggagagga ttgccaattg
    16681 cttcggccat gatcggtaga cttgtgatga tcagctgcac atttttcttc ttcaagtaat
    16741 tgactgaagc gatgatctcg tcgtaatttc ttccaagtcg atcaatagct tccacaataa
    16801 aaatatcttg atctcggacg aaatccagtg cttcttgaaa aacaagtcga tgagtaatcg
    16861 ttgcgccaga ttgtttctca atgaaaattc tctctgcacc gaattttttc atttcttcaa
    16921 tctgccgttg ttcattttga tcgatggatg agacacgtat gtatgcaact ctcaaaattt
    16981 ttacctactt tctgcaacta tttaaaaaac accctaatca tacacgagaa aaccagattt
    17041 ttcaatgtcg cggtcgtgtc tagttagggt ataccttata tagacaaaaa ctaatgatgg
    17101 aggaaatagt atgtgtcact tttcttttta aatggcaata ttttttgtaa ataaatgtca
    17161 atcaagaaaa tttaaacgat tatgacatta aaaatatatt ttatgaattt tctagtatat
    17221 aacttgattt atctgttaag atttattaag aaaacgtttt cttatttttg atttcgaggt
    17281 gatagacaat gaaaaataag tttattttat ctttaggtat tttaactatt ggaattagtg
    17341 taactggaac tacaattcct acatttgctg atagtacaaa tgaaccaact actgtagtag
    17401 ataataacca agaattaact cctttagata ggaacggaat agccattggt aacccaacta
    17461 acgacttaac tgttactgaa aattatttaa tagtttctcc attacttgct cgagcagctt
    17521 ctaaaacgat acgagtgaca ggaacgatga tttttgataa agttggttgg ccttctagac
    17581 ctcctcaatc acggaattgg aaagaaaaaa gaaatggtta ttggtactat ggaaaattgt
    17641 atttacaaag ttataaatca gctggaaaca attggattgc gacttattca ggaaccttaa
    17701 ctagaaagta gggatttttt atgccagaat ttgtgaacac accaaatttt tatcaagata
    17761 gcgatattct aagtaaaatt aatttaccga aagaagaatc agctttacaa gttcagcgaa
    17821 ctttacagga gacacaaaaa attcaaaaat caatttctaa tctagaagat tctgaagaaa
    17881 aaagaaaaaa aagagaccaa aaaacatatc aaaaagaaaa ataatgattt taaaaaaaga
    17941 gtgtctagtc gacattcttt ttttctaatt gaaagtgttc ataaaatcac ccatttctgg
    18001 acactttctt tttttgcttt atttttcaaa aaaacaattc atttcatgtt cataaaccca
    18061 taacaatatc tatgttcagt taaactatat ggataaagtt atgttacaat aaaattaatg
    18121 aaggagtgat ttttttgaaa ataggatacg cccgggtatc tactggttta caaaatttgg
    18181 atttacaaga agacagccta aataaatttg gttgtgaaaa aatttttact gatcatatga
    18241 gtggggcaaa aagtaatcga ccaggattag aaatggccat tgattttgtt cgctctggcg
    18301 atacacttgt cgtttggcgc ttagatcgtt taggtagaaa tatggaagat ttgatttcaa
    18361 tcgtcaatcg actgaatgag cgtggtgtga gttttcatag tattcaagaa aatattacga
    18421 tggacaaatc aagttctaca ggacagctca tgtttcattt gtttgcggca tttgcagaat
    18481 ttgagcgtaa tttgatcctg gaacgatccg cagcaggacg agcagctgct cgtgcaagag
    18541 gacggtttgg tggtcgtcct gaaaaattgt ctgaacaaga tttggaatta ctgaagactt
    18601 tagtggatag cggtacacct attaagacta ttgcggaacg gtggaacgtc tcaagaacca
    18661 ccatttatcg ttatttggca aaaatggagg agaaaaatgg aaagacaaat tctcattagt
    18721 ttttgtcatt taatgctgaa aatttttgcc atttatctag aaaagtgaca atagtatgag
    18781 aattttttgt aagtgtctac tgataactta ttatcaaatg ttgtaaggat tttattcatt
    18841 tgttaatatt aaagaacgga actccaaaaa agtccgtact ctaatttgca gtctctcact
    18901 cttttagagt gagagttttt attagatttt caaattaatt agtaaagtga tagaataaat
    18961 tgatcataca aatcataaga agaagcaggg tgatagcata cctatgcttc tttttttatg
    19021 tatttagcta tttcttcttt acaacatcga acatatgttt gtataatgtg gaagaatgga
    19081 gtgttattta tgatggatta ttcaaaagag ccagtaaatg attacttttt aatcgatatg
    19141 aaaagctttt acgcaagtgt cgaatgtata gaaagaaatt tagatccatt aacaacagaa
    19201 cttgttgtta tgagtcgatc tgataatact ggttcaggat tgatattagc ttcttctcct
    19261 gaagcaaaaa agcggtatgg tattacaaat gtgagtagac cacgtgactt accacaacca
    19321 tttcctaaaa cactacacgt tgttccacca cgtatgaacc tatatatcaa gcgaaatatg
    19381 caggtaaata atattttcag aagatatgtg gctgatgaag atctactgat ttactcgatc
    19441 gatgaatcga ttttaaaagt gacaaaatca ctgaatcttt ttacgactga agaaacacga
    19501 agtcagcgaa ggaagaagct cgctcaaatg atccaagaac gtattaaaga agagttaggt
    19561 ttgattgcta cggtaggcgt cggcgataat ccccttttgg ctaaattagc cttagacaat
    19621 gaagcaaagc ataatgaagg atttattgcg gaatggacgt acgaaaacgt tcctgagaaa
    19681 gtatggaata ttcccgaaat gacggacttt tggggaattg gttctcgaat gaaaaaaagg
    19741 ctcaaccaaa tgggaatttt gagcattaga gaccttgcta actggaatcc ttatacgatt
    19801 aagaatagat taggtgtgat tggattacag ctgtacttcc atgctaacgg aatcgatcga
    19861 acagatatag caatcccgcc agaaccgaca aaggaaaaat cttatggtaa ttcacaagtg
    19921 ttaccacgag attatactag aagaaatgaa atcgagctgg tggtaaaaga aatggcggaa
    19981 caagtagcca ttcgtatcag gcagcataat tgtaaaacag gatgtgttca tttaaacatt
    20041 ggtacgtcga tcttagaaac gagaccagga ttttcacacc agatgaaaat acctatcaca
    20101 gataatacaa aggaattgca gaattattgt cttttcttgt ttgataagta ttatgaagga
    20161 caagaagtaa ggcacgttgg aataacctat agcaagcttg tgtacaccga ttcgcttcag
    20221 ctggatttat ttagtgatcc acaaaagcaa attaacgaag aaaatttaga taaaattatt
    20281 gacaagattc ggcaaaaata tggttttacg tcgattgtac atgcttcttc aatgttagaa
    20341 agcgctagaa gcattactag aagcacactt gttggtggtc atgcgggcgg aaatggggga
    20401 attaaaaatg attgattaca atgatcgtgg acgtttaaag tgggcagggt tttatttatc
    20461 tgatcatact gaagaaattg atgccgacaa tgaacaacga accagtcaaa atttagcaaa
    20521 agaacaaatg acgactgaag agattgcgga agtattgaac gctgcagtca taaaaaatag
    20581 atcagtatct attcaaaaag aagaacgaaa cgctgaagga tactatccag aagatattgt
    20641 tggcaagatc ttaggtagtg atgagctggg gatctacgtt ggaaaagaca aaattcacta
    20701 cgacgaaata cgtcatatcg aattttacca ggataataaa tggagtcgat tagaatgaac
    20761 attatccagc aatatgagct aaagtatata acctttgatc agctatcaga agagatttgg
    20821 ggttatggcc aacgtttgat aaatgaggtt ggtgttgagc gcttctcttt ctatgtagaa
    20881 gctgcagcag gttatcataa ttttaggttt tatattttcc cgttatatat ataaggtatt
    20941 ttacggattc tatagagtta tctctatgaa tccttttttg tttttacaaa taggagtaga
    21001 tactagaata atgcgtgtgt taaactatta ttgcaaacgc aataataaaa gaaagtaggc
    21061 ttacgcacca tgtctatcaa tacatttgtt tactcgcacc cgatcaatgt ttacattatc
    21121 aagaatttag gaatcactgt agaacaattt tgtgagttat atgcctaccc acaaggaacg
    21181 gttgcaagct ggataacccg acaacgtaga ataaaatcat tacctgcttc attcgtttat
    21241 gatttaagcc tggcctctag tttaaacatg tctgatgttt atgaaaagct cctgtcttta
    21301 gaaaaagaat atgattcctt caagattaaa catgataaaa aaataaaaaa acatatataa
    21361 tatcaatcac aattgtataa tattacgata tcttaatatc atgatatcgt aatattgttt
    21421 ttttctaaga aaatgcacta taagaaggga attattagta acaatataga cagtttaata
    21481 atgtttaaat tattctagtt gctgctcgca aaacatattt cttatgatta ataaaaaatt
    21541 ttaaagtaat aaaaagtgat tattttactt tcgaataaca tatgaataat ctttatatcc
    21601 gaaccgatat atatctttaa aacaaaataa tcacacaata ttacaatata atgcatatac
    21661 gatattgcaa tatcacaata ttatgatata attatattat aatataagat gaatggggga
    21721 tattttaatg gcaagaatat tgtcagtagc caatcaaaaa ggtggagttt ctaaaactac
    21781 gactagcgtt aatttagcag catgtttgaa atttgtttac ggtaaaaatg tacttttagt
    21841 ggacattgat cctcagggaa atgctacaga taatgtaggt ttcgatatag atggaacaaa
    21901 ccaacctaca atttatgaag tattaaaagg ggaggctgac attacagatg ctattctgga
    21961 ctataaagga attgatgttt tgccagccga catagccctt tcttctgcag agagggaatt
    22021 tactcaagta ggaagtgaac acaggcttaa aagagtactt caaccaatca aggacaacta
    22081 tgattatatt ataattgatt gtccaccaag tttaggaatg cttacagtca acgcatttac
    22141 tgtttctgat gaaattatca ttccagttga agctgcgtat ttctcattaa aaggactaat
    22201 aaagttaagt gaaactattg aaacggtaaa agaatatacg aacgacaagc ttgaagtacg
    22261 aggagtccta tttactaagt ataataagcg ttataacatt tctaaagaaa tgacgactgc
    22321 agcaaccgaa atttctagag tcattggtgc aaaaattttc aaaacttata ttcgtagaac
    22381 aataaccgtt gacgaagcgc aagctgctgg atcagatcta atcaatttta ataaaccctc
    22441 aacagctgaa gatgactata aagcatttac agaagaatat ttaaaagaag ttggtgattt
    22501 tgatggcaga agataatcgc agtcaagctg cagtaagtag actactagga aataaaaata
    22561 aaaagaacta caaaccaaaa gaagtagaag aaatcgaatt aaccaagaaa aatataagta
    22621 aagtcataaa agatcaagga agtagtgtaa gaacagcaga tagcattcgt ataaatccaa
    22681 ttctaatgtc agcactcaaa tattggacga ctattgctga atcagacaaa agtaaaccag
    22741 acgttataga agatgcgcta ttaaaatcca tacctgaaga atacttgatt gaaggatata
    22801 aactagcaaa gaaacaaaat aaaatttaat ttacattcaa tatcacgata tcataatatc
    22861 gtgatatttt ttttataaaa atcagtagta tcaaagctga taagtcgctt atcttcatat
    22921 tgtaatatta cgatatcgtg atataatgtt attgtaatat cgtgatatag ttaccatgag
    22981 cttaaaccct gaaatagagc ggtttgcttt aatttatttt ttaaggtaaa ctaaaaaaag
    23041 ataaaaaaag actactgctt taacaaagtt tggcgactta tcagcagtag aaaaatatat
    23101 agtggataga tatatttgtt taattcattg taacatagtt ttgaacaaaa cgctatccta
    23161 cagaaagagg attggct
//
