LOCUS       NZ_CP085898            23182 bp    DNA     circular CON 23-DEC-2023
DEFINITION  Enterococcus faecium strain SC1762 plasmid p4, complete sequence.
ACCESSION   NZ_CP085898
VERSION     NZ_CP085898.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN22627481
            Assembly: GCF_020736585.1
KEYWORDS    RefSeq.
SOURCE      Enterococcus faecium
  ORGANISM  Enterococcus faecium
            Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
            Enterococcus.
REFERENCE   1  (bases 1 to 23182)
  AUTHORS   Zeng,W.
  TITLE     Acquisition of daptomycin resistance by Enterococcus faecium confers
            collateral sensitivity to glycopeptides
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 23182)
  AUTHORS   Zeng,W.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-OCT-2021) Laboratory Medicine, College of Life
            Sciences, Wenzhou Medical University, Wenzhou Medical University,
            Wenzhou, Zhejiang 325000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: unicycler v. v0.4.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 200.0x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 12/23/2023 20:51:41
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,307
            CDSs (total)                      :: 3,216
            Genes (coding)                    :: 3,059
            CDSs (with protein)               :: 3,059
            Genes (RNA)                       :: 91
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 157
            CDSs (without protein)            :: 157
            Pseudo Genes (ambiguous residues) :: 0 of 157
            Pseudo Genes (frameshifted)       :: 63 of 157
            Pseudo Genes (incomplete)         :: 95 of 157
            Pseudo Genes (internal stop)      :: 38 of 157
            Pseudo Genes (multiple problems)  :: 30 of 157
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP085898.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..23182
                     /organism="Enterococcus faecium"
                     /mol_type="genomic DNA"
                     /strain="SC1762"
                     /host="Homo sapiens"
                     /db_xref="taxon:1352"
                     /plasmid="p4"
                     /geo_loc_name="China:wenzhou"
                     /collection_date="2018"
     gene            1..1041
                     /locus_tag="LK894_RS16095"
                     /old_locus_tag="LK894_16110"
     CDS             1..1041
                     /locus_tag="LK894_RS16095"
                     /old_locus_tag="LK894_16110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002343466.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiator protein A"
                     /protein_id="WP_002302900.1"
                     /translation="MNDFNYYKSKEIYREKYYQMPKVFFTNEKYMDLSNDAKIAYMLLK
                     DRFDYSVKNNWVDSDDNIFFIFTVEELMKLLQCREGKVSKIKKELEKAGLLKQKRGRVN
                     KRDGKIESMPNLLYLGKPEVTNQDVFKIMEEEDNTDSTVIAKIANTAKPRKINDSTVIA
                     KIANTAKSSHIKDSTVIAKIADNLFYSNSIDTNRHIIDTETDQLQNQVLLDNFVDIMQE
                     DSINTFVPENVLNLIKTFSSSYSEAQQTVQTIHNAKKKAEELEQTIVVYEELESYGIDA
                     DKGLYMTLLKAYQKQKTEKVNNLQNLIFVYVKNWFVEKAIAAKLANEQRETFNELPTVS
                     TENWLE"
                     /name="replication initiator protein A"
     gene            complement(1661..2341)
                     /locus_tag="LK894_RS16100"
                     /old_locus_tag="LK894_16115"
     CDS             complement(1661..2341)
                     /locus_tag="LK894_RS16100"
                     /old_locus_tag="LK894_16115"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="WP_001015311.1"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            complement(<2418..2564)
                     /locus_tag="LK894_RS16105"
                     /old_locus_tag="LK894_16120"
                     /pseudo=""
     CDS             complement(<2418..2564)
                     /locus_tag="LK894_RS16105"
                     /old_locus_tag="LK894_16120"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002311815.1"
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006270 - DNA replication initiation
                     [Evidence IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="RepB family plasmid replication initiator
                     protein"
                     /name="RepB family plasmid replication initiator protein"
     gene            3248..3334
                     /locus_tag="LK894_RS16110"
                     /old_locus_tag="LK894_16125"
     CDS             3248..3334
                     /locus_tag="LK894_RS16110"
                     /old_locus_tag="LK894_16125"
                     /inference="COORDINATES: protein motif:HMM:NF033608.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="WP_125669474.1"
                     /translation="MFTNFICSLLVGLLSALFSYWLNNRNKK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            complement(3636..3860)
                     /locus_tag="LK894_RS16115"
                     /old_locus_tag="LK894_16130"
     CDS             complement(3636..3860)
                     /locus_tag="LK894_RS16115"
                     /old_locus_tag="LK894_16130"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000410576.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000410576.1"
                     /translation="MEKFPYEYFQNLEKLEQAIQAIKFDLTDEKLLEYKNMTPERKRSL
                     EKLMQLVNEDGGISDAAFDAWSEFHGEYN"
                     /name="hypothetical protein"
     gene            4226..4510
                     /locus_tag="LK894_RS16120"
                     /old_locus_tag="LK894_16135"
     CDS             4226..4510
                     /locus_tag="LK894_RS16120"
                     /old_locus_tag="LK894_16135"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002337999.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000353844.1"
                     /translation="MDILVRNIDPKFVATIDKRCQELTNKTGEKWSRNKYLKVLIESDF
                     DRQLTTYKKDQFDLLLDKFIAIQTENTQILSEYVYTNNQIIEMLIGGMI"
                     /name="hypothetical protein"
     gene            4513..4929
                     /locus_tag="LK894_RS16125"
                     /old_locus_tag="LK894_16140"
     CDS             4513..4929
                     /locus_tag="LK894_RS16125"
                     /old_locus_tag="LK894_16140"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001232859.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001232859.1"
                     /translation="MRKTSVQKHVTLYPSHVDVLDSIIEKNPDINNYSEAIRFLCMSYE
                     PDTNTTTTSNQAKLNAMGKEISIMTEIIAEFADLYLKDTGVLIGTNSKVYQEVKEKIEA
                     KLNPSNRNRPKNHQKETSQTVTSRNFDPTNFLKR"
                     /name="hypothetical protein"
     gene            complement(5066..>5557)
                     /locus_tag="LK894_RS16130"
                     /old_locus_tag="LK894_16145"
                     /pseudo=""
     CDS             complement(5066..>5557)
                     /locus_tag="LK894_RS16130"
                     /old_locus_tag="LK894_16145"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002311815.1"
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006270 - DNA replication initiation
                     [Evidence IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /name="replication initiation protein"
     gene            complement(5612..6292)
                     /locus_tag="LK894_RS16135"
                     /old_locus_tag="LK894_16150"
     CDS             complement(5612..6292)
                     /locus_tag="LK894_RS16135"
                     /old_locus_tag="LK894_16150"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="WP_001015311.1"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            complement(6426..7430)
                     /locus_tag="LK894_RS16140"
                     /old_locus_tag="LK894_16155"
     CDS             complement(6426..7430)
                     /locus_tag="LK894_RS16140"
                     /old_locus_tag="LK894_16155"
                     /EC_number="3.5.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002344006.1"
                     /GO_function="GO:0097367 - carbohydrate derivative binding
                     [Evidence IEA]; GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SIS domain-containing protein"
                     /protein_id="WP_016173088.1"
                     /translation="MLKFNEQKQIDDIQGALDLRPEVEKIIDSVWEKGFDNIYYLGIGG
                     TYASAMQAVTYINGKSNLPAYVQHAAEYYTTGNKRLTKDSIVVLSSVTGTTQEVVKAVD
                     EIKTVGATLIGFIDTEHSPLAEKCDYVITYPAPGTEQIKFFMVADRLMKNNGEFDDYED
                     YYQELEGHLAKGLVEAEKQADAFGLEFAEKHRHDAMHYFIGAGNQWGAVYSYAMCYWEE
                     QSWLRSKSIHAAEFLHGTLEIVDETTPVTLFLGEDEQRPLAERVKNLLPRICGNYTFID
                     SKDYAVEGISEKYRGRVLSFLLMHCVTQRIDAHVEKLNCHPLEIRRYYRQFDY"
                     /name="SIS domain-containing protein"
     gene            complement(7454..8503)
                     /locus_tag="LK894_RS16145"
                     /old_locus_tag="LK894_16160"
     CDS             complement(7454..8503)
                     /locus_tag="LK894_RS16145"
                     /old_locus_tag="LK894_16160"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016173089.1"
                     /GO_function="GO:0097367 - carbohydrate derivative binding
                     [Evidence IEA]"
                     /GO_process="GO:1901135 - carbohydrate derivative metabolic
                     process [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SIS domain-containing protein"
                     /protein_id="WP_016173089.1"
                     /translation="METMLDYINEEEATLQNILADFSLKKVSGYEKINNLLILATGSSY
                     NACLAAKVTLEKFADIAITIEEPYNFNHYGRISNSVDAVLAVSQSGKSASTIDAIAKLK
                     KEGLFTLALTSDVSSPIATVVDEVIDLEMGIEKVGFVTKGYVSSVLQLFLLGLTIGYNK
                     QTLSQRQLDYYQRELKKVIAAIPDTIEKTNNFFTVHEAIFKLGTRFIAIGYGPNWGTAK
                     EFETKFTETVRKPSQGFELEAYMHGPYLEADSEHILFFIETKSVNEARSQSLKNYMNPY
                     VGTTITVTTANTKNETELGLAIECDELISSLLLVIPFQILAYKIATAKGIDLSQRIFDD
                     FDQVLKSKV"
                     /name="SIS domain-containing protein"
     gene            complement(8516..9337)
                     /locus_tag="LK894_RS16150"
                     /old_locus_tag="LK894_16165"
     CDS             complement(8516..9337)
                     /locus_tag="LK894_RS16150"
                     /old_locus_tag="LK894_16165"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010760606.1"
                     /GO_component="GO:1902495 - transmembrane transporter
                     complex [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]; GO:0009401 - phosphoenolpyruvate-dependent sugar
                     phosphotransferase system [Evidence IEA]; GO:0016310 -
                     phosphorylation [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS system mannose/fructose/sorbose family
                     transporter subunit IID"
                     /protein_id="WP_016173090.1"
                     /translation="MTKTSNTDLKITKKDLSKVFWRSFQMEFSWNYERQMNMAYAYAMI
                     PILKKLYQTKEQMADALKRHLEFFNTTPHIVTLILGINAAMEEENVNDPDFDTSAIDSI
                     KTSLMGPLAGIGDSFFWGTLRLIATGVGTSLALQGNILGPILFLLIFNIPHILFRYLAT
                     SWGYKLGTGFLKKIQENGMMESLTLGASIIGLMVVGGMTATMIDINLPMKIGSGENAVT
                     VQSIFDDIVPKILCLGVFGAVFYLLKKEVKPLTILLGLAVVGILGSLVGIF"
                     /name="PTS system mannose/fructose/sorbose family
                     transporter subunit IID"
     gene            complement(9321..10112)
                     /locus_tag="LK894_RS16155"
                     /old_locus_tag="LK894_16170"
     CDS             complement(9321..10112)
                     /locus_tag="LK894_RS16155"
                     /old_locus_tag="LK894_16170"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002340241.1"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0034219 - carbohydrate transmembrane
                     transport [Evidence IEA]; GO:0009401 -
                     phosphoenolpyruvate-dependent sugar phosphotransferase
                     system [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIC"
                     /protein_id="WP_016173091.1"
                     /translation="MIVQAILLGIVAFIAQSEYALGTSLLSRPIVTGLFTGIVLGDIKT
                     GIIMGATLELAFIGSFSVGASIPPDVVTGGILGTAFAITAGAGTETALLLGLPIATLTL
                     ILKNIYLGLLIPIMNHKADDYAAEGNYKGVERMHLCAGFGLSLMLGLIVMISFMVGSKT
                     IGNLLAMIPEFVQHGLSVATGLIPALGFAMLARLLINKKVAPYFFLGFALAAYLEIPVT
                     GIAIFGAIVAVVVVNIMNVRSNQAPQVQATTGEVVDDDEDF"
                     /name="PTS sugar transporter subunit IIC"
     gene            complement(10131..10601)
                     /locus_tag="LK894_RS16160"
                     /old_locus_tag="LK894_16175"
     CDS             complement(10131..10601)
                     /locus_tag="LK894_RS16160"
                     /old_locus_tag="LK894_16175"
                     /EC_number="2.7.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016629538.1"
                     /GO_function="GO:0008982 -
                     protein-N(PI)-phosphohistidine-sugar phosphotransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]; GO:0009401 - phosphoenolpyruvate-dependent sugar
                     phosphotransferase system [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PTS sugar transporter subunit IIB"
                     /protein_id="WP_016173092.1"
                     /translation="MIILTRVDHRLLHGQVAFSWTQSLGADCILIANDDVPNNEVRKTT
                     IKLAKPQGVKLVIKNIADSIAALQSGVTDKYKLFIVVESVGDAYKLAEAYPEIKKINLG
                     GTKVKEGTRSIGKAVNVLPEEEELLKKLVDQGVEVEIRQVPNDKKVNVTEVL"
                     /name="PTS sugar transporter subunit IIB"
     gene            complement(10620..11039)
                     /locus_tag="LK894_RS16165"
                     /old_locus_tag="LK894_16180"
     CDS             complement(10620..11039)
                     /locus_tag="LK894_RS16165"
                     /old_locus_tag="LK894_16180"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016173093.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_016173093.1"
                     /translation="MERKMILASHGKFASGILSSLELICGKNDNITTLDCYITEDFDLT
                     KAVDELMHQNEGTEVVVVTDLFGGSVNNEFLRYINREHFYLVAGMNLPFLIEFATQFAF
                     VPELKTTITSVLDSSKEAIQFCNLTYQTTVAEEDF"
                     /name="hypothetical protein"
     gene            complement(11114..13882)
                     /locus_tag="LK894_RS16170"
                     /old_locus_tag="LK894_16185"
     CDS             complement(11114..13882)
                     /locus_tag="LK894_RS16170"
                     /old_locus_tag="LK894_16185"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016173094.1"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA];
                     GO:0008134 - transcription factor binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sigma-54-dependent transcriptional regulator"
                     /protein_id="WP_016173094.1"
                     /translation="MKEELVTYLENQTAFIDLHHLSEVFTAQKLAEIFEVKRNTISHYL
                     NQLNEAGILVKINSRPVYYFHKEAFEKEFFFLRDNFYQSSEEILKEQPLFEQQKDLFSL
                     LIGHDKSLTRAVEQIKTALYYPDNGLPTLITGESGTGKSFLVRLIHKYCLENELIKEDA
                     PLITLNCAQYANNPELLTSNLFGHVKGAYTGADSDKVGAFEAADGGILFLDEVHRLNAE
                     GQEKLFTYLDQGIIYPMGATNQPIKVKTRLFFATTEDLESSFLTTFMRRIPIQVTLPPI
                     NARSRNERLELVYSFLLSEVRKIKRPLKVSGQVLTLLTSSSFKGNIGELKNTVKVTVAK
                     AFAEQKQAAEIKVTIYQLPEKLLLPATENLQTVLQKDTVITENTTITQLLEKNHPQQQR
                     VIATFDRIITEFSKQQQLTACEEQLKQEVETLFDFLLFETDRQQKQEMLIYLTQYIRDT
                     FKQMESAYQIKFNGNAVYAISYYLFQRGAGKWYPEDVAILGLIKELEQQVATKYAASYQ
                     YVKRLLELCQPKLDLEISEMDCILLTIYLNRADWQKELGIPRGIIVAHGYATASSIANV
                     ANRFLAKDIFASFDMPLDVTPQQIAEEILDYSENHDVSNGLVILVDMGSLKEIYQFFPK
                     QITAPVVIMNNVTTPLAIAMGENLQKALPLAEMIETAAQQAPLDWEIIYPAENKMKALI
                     TTCLTGIGTATHISQLLEKSLPATVELKIFPYEYDVLKEQKKNETIFSMYDVLGIIGTS
                     DPEIADIPYLSLEELISGDENQLLSEWLSTCLSPLENATFNTNVIRNFSLEKVIDSVTI
                     LDTEKVMGEIEIFMRELEANSGLVISNAKKLALYVHVSCLIERLIRNIPIDTYAGYELL
                     YQCQKTALVAIKNAFSVIENDYSVKIPDSEIAYIYDIVYQNTDNMPIDEDF"
                     /name="sigma-54-dependent transcriptional regulator"
     gene            complement(14030..14698)
                     /locus_tag="LK894_RS16175"
                     /old_locus_tag="LK894_16190"
     CDS             complement(14030..14698)
                     /locus_tag="LK894_RS16175"
                     /old_locus_tag="LK894_16190"
                     /inference="COORDINATES: protein motif:HMM:NF023568.3"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_322746435.1"
                     /translation="MIDTVRDFILYLKLCNRTIISDFIQTKYPTLPLYLFGHSFGSIIA
                     RNYLQKNDDRIAKVALTGTANYVPVVPLGIAAGKLFLRFNEKDKQNKLLNWLSGNMGVE
                     HDWLSNNPVNNLQCQQDEKMVPIYPVRSLLTIWEGDYQLKNYAAFQCHNPQLPILSVVG
                     AEDVKITGGKKGLADTIATLNKIGYQNVRSVEMPGMKHEVLNEYQKEDVYDLLLQFFNE
                     "
                     /name="alpha/beta hydrolase"
     gene            complement(14699..15379)
                     /locus_tag="LK894_RS16180"
                     /old_locus_tag="LK894_16195"
     CDS             complement(14699..15379)
                     /locus_tag="LK894_RS16180"
                     /old_locus_tag="LK894_16195"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="WP_001015311.1"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            complement(15417..15581)
                     /locus_tag="LK894_RS16185"
                     /old_locus_tag="LK894_16200"
     CDS             complement(15417..15581)
                     /locus_tag="LK894_RS16185"
                     /old_locus_tag="LK894_16200"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002326887.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_164450253.1"
                     /translation="MFKKTKSLESGKKKIDLKIISSGYFKDFIVIDTKWNKKDIENMVL
                     LQSFKSTIK"
                     /name="hypothetical protein"
     gene            15735..15998
                     /locus_tag="LK894_RS16190"
                     /old_locus_tag="LK894_16205"
     CDS             15735..15998
                     /locus_tag="LK894_RS16190"
                     /old_locus_tag="LK894_16205"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002329851.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002287514.1"
                     /translation="MEMLPIKKWGNSNGLRLPKYIMEYLGIHTEDKVKIIQEEVNGQKR
                     LIIEAANIENELTIEQLFENYTDERNHVTIQNLGEAVGNEKW"
                     /name="hypothetical protein"
     gene            15992..16342
                     /locus_tag="LK894_RS16195"
                     /old_locus_tag="LK894_16210"
     CDS             15992..16342
                     /locus_tag="LK894_RS16195"
                     /old_locus_tag="LK894_16210"
                     /EC_number="3.1.-.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016610020.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0003723 - RNA binding [Evidence IEA]; GO:0004521 - RNA
                     endonuclease activity [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system PemK/MazF family
                     toxin"
                     /protein_id="WP_002321032.1"
                     /translation="MVRKPRQGDILLLNTAPRSGHEQTGKRPYIVLSHDIIADYSNVVT
                     VAPISSTTRNYPLYVNINSEYEMKTTGKVLLDQLTTIDYEARECIFLEKAHDSLVEELL
                     MKVRTVFQKVSK"
                     /name="type II toxin-antitoxin system PemK/MazF family
                     toxin"
     gene            complement(16366..16980)
                     /locus_tag="LK894_RS16200"
                     /old_locus_tag="LK894_16215"
     CDS             complement(16366..16980)
                     /locus_tag="LK894_RS16200"
                     /old_locus_tag="LK894_16215"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001261742.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_010729795.1"
                     /translation="MRVAYIRVSSIDQNEQRQIEEMKKFGAERIFIEKQSGATITHRLV
                     FQEALDFVRDQDIFIVEAIDRLGRNYDEIIASVNYLKKKNVQLIITSLPIMAEAIGNPL
                     LDKFIKDLIIQILAMIAEQERTESKRRQAQGIKIAKANGVYKGRPKLYSANAKDPQRRL
                     VYKNIVEDLKKGVAIAKIAKDYNVTRQTVYRIKKDSMVNHE"
                     /name="recombinase family protein"
     gene            17294..17716
                     /locus_tag="LK894_RS16205"
                     /old_locus_tag="LK894_16220"
     CDS             17294..17716
                     /locus_tag="LK894_RS16205"
                     /old_locus_tag="LK894_16220"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002303116.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002288787.1"
                     /translation="MKNKFILSLGILTIGISVTGTTIPTFADSTNEPTTVVDNNQELTP
                     LDRNGIAIGNPTNDLTVTENYLIVSPLLARAASKTIRVTGTMIFDKVGWPSRPPQSRNW
                     KEKRNGYWYYGKLYLQSYKSAGNNWIATYSGTLTRK"
                     /name="hypothetical protein"
     gene            17726..17929
                     /locus_tag="LK894_RS16210"
                     /old_locus_tag="LK894_16225"
     CDS             17726..17929
                     /locus_tag="LK894_RS16210"
                     /old_locus_tag="LK894_16225"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016631607.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002299573.1"
                     /translation="MPEFVNTPNFYQDSDILSKINLPKEESALQVQRTLQETQKIQKSI
                     SNLEDSEEKRKKRDQKTYQKEK"
                     /name="hypothetical protein"
     gene            18140..18724
                     /locus_tag="LK894_RS16215"
                     /old_locus_tag="LK894_16230"
     CDS             18140..18724
                     /locus_tag="LK894_RS16215"
                     /old_locus_tag="LK894_16230"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007207927.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_002299575.1"
                     /translation="MKIGYARVSTGLQNLDLQEDSLNKFGCEKIFTDHMSGAKSNRPGL
                     EMAIDFVRSGDTLVVWRLDRLGRNMEDLISIVNRLNERGVSFHSIQENITMDKSSSTGQ
                     LMFHLFAAFAEFERNLILERSAAGRAAARARGRFGGRPEKLSEQDLELLKTLVDSGTPI
                     KTIAERWNVSRTTIYRYLAKMEEKNGKTNSH"
                     /name="recombinase family protein"
     gene            19095..20420
                     /locus_tag="LK894_RS16220"
                     /old_locus_tag="LK894_16235"
     CDS             19095..20420
                     /locus_tag="LK894_RS16220"
                     /old_locus_tag="LK894_16235"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002335330.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Y-family DNA polymerase"
                     /protein_id="WP_002303115.1"
                     /translation="MMDYSKEPVNDYFLIDMKSFYASVECIERNLDPLTTELVVMSRSD
                     NTGSGLILASSPEAKKRYGITNVSRPRDLPQPFPKTLHVVPPRMNLYIKRNMQVNNIFR
                     RYVADEDLLIYSIDESILKVTKSLNLFTTEETRSQRRKKLAQMIQERIKEELGLIATVG
                     VGDNPLLAKLALDNEAKHNEGFIAEWTYENVPEKVWNIPEMTDFWGIGSRMKKRLNQMG
                     ILSIRDLANWNPYTIKNRLGVIGLQLYFHANGIDRTDIAIPPEPTKEKSYGNSQVLPRD
                     YTRRNEIELVVKEMAEQVAIRIRQHNCKTGCVHLNIGTSILETRPGFSHQMKIPITDNT
                     KELQNYCLFLFDKYYEGQEVRHVGITYSKLVYTDSLQLDLFSDPQKQINEENLDKIIDK
                     IRQKYGFTSIVHASSMLESARSITRSTLVGGHAGGNGGIKND"
                     /name="Y-family DNA polymerase"
     gene            20413..20763
                     /locus_tag="LK894_RS16225"
                     /old_locus_tag="LK894_16240"
     CDS             20413..20763
                     /locus_tag="LK894_RS16225"
                     /old_locus_tag="LK894_16240"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002359653.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002303114.1"
                     /translation="MIDYNDRGRLKWAGFYLSDHTEEIDADNEQRTSQNLAKEQMTTEE
                     IAEVLNAAVIKNRSVSIQKEERNAEGYYPEDIVGKILGSDELGIYVGKDKIHYDEIRHI
                     EFYQDNKWSRLE"
                     /name="hypothetical protein"
     gene            20760..20939
                     /locus_tag="LK894_RS16230"
                     /old_locus_tag="LK894_16245"
     CDS             20760..20939
                     /locus_tag="LK894_RS16230"
                     /old_locus_tag="LK894_16245"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001021554.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001021554.1"
                     /translation="MNIIQQYELKYITFDQLSEEIWGYGQRLINEVGVERFSFYVEAAA
                     GYHNFRFYIFPLYI"
                     /name="hypothetical protein"
     gene            21075..21365
                     /locus_tag="LK894_RS16235"
                     /old_locus_tag="LK894_16250"
     CDS             21075..21365
                     /locus_tag="LK894_RS16235"
                     /old_locus_tag="LK894_16250"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000026576.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000026576.1"
                     /translation="MSINTFVYSHPINVYIIKNLGITVEQFCELYAYPQGTVASWITRQ
                     RRIKSLPASFVYDLSLASSLNMSDVYEKLLSLEKEYDSFKIKHDKKIKKHI"
                     /name="hypothetical protein"
     gene            21733..22521
                     /locus_tag="LK894_RS16240"
                     /old_locus_tag="LK894_16255"
     CDS             21733..22521
                     /locus_tag="LK894_RS16240"
                     /old_locus_tag="LK894_16255"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002302898.1"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA];
                     GO:0016887 - ATP hydrolysis activity [Evidence IEA]"
                     /GO_process="GO:0007059 - chromosome segregation [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="AAA family ATPase"
                     /protein_id="WP_002302898.1"
                     /translation="MARILSVANQKGGVSKTTTSVNLAACLKFVYGKNVLLVDIDPQGN
                     ATDNVGFDIDGTNQPTIYEVLKGEADITDAILDYKGIDVLPADIALSSAEREFTQVGSE
                     HRLKRVLQPIKDNYDYIIIDCPPSLGMLTVNAFTVSDEIIIPVEAAYFSLKGLIKLSET
                     IETVKEYTNDKLEVRGVLFTKYNKRYNISKEMTTAATEISRVIGAKIFKTYIRRTITVD
                     EAQAAGSDLINFNKPSTAEDDYKAFTEEYLKEVGDFDGRR"
                     /name="AAA family ATPase"
     gene            22508..22834
                     /locus_tag="LK894_RS16245"
                     /old_locus_tag="LK894_16260"
     CDS             22508..22834
                     /locus_tag="LK894_RS16245"
                     /old_locus_tag="LK894_16260"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002299230.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002299230.1"
                     /translation="MAEDNRSQAAVSRLLGNKNKKNYKPKEVEEIELTKKNISKVIKDQ
                     GSSVRTADSIRINPILMSALKYWTTIAESDKSKPDVIEDALLKSIPEEYLIEGYKLAKK
                     QNKI"
                     /name="hypothetical protein"
     Typing          2..1041
                     /name="rep_cluster_889"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="99.904"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(5067..5557)
                     /name="rep_cluster_1763"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="89.0"
                     /evalue="0.0"
ORIGIN
        1 atgaatgatt ttaattatta caaatcaaaa gaaatttatc gtgaaaaata ttatcaaatg
       61 cctaaggtat tttttactaa cgaaaaatac atggatcttt caaatgatgc aaaaattgct
      121 tatatgctac ttaaagatcg atttgattat tcagtcaaaa ataactgggt agattctgat
      181 gataatatat tcttcatatt cacagttgaa gaattaatga aattgttaca atgccgcgaa
      241 ggtaaagtat ctaagatcaa aaaagaatta gaaaaagcag gtcttctgaa acagaagaga
      301 ggaagagtaa ataaacgtga tggtaagatt gaatctatgc ctaatttatt gtacttaggc
      361 aagccagaag ttacgaatca agacgtcttt aaaatcatgg aagaggaaga caatactgat
      421 tccaccgtaa ttgcgaaaat cgcaaatacg gcaaaaccgc gaaaaatcaa tgattctacc
      481 gtaattgcga aaatcgcaaa tacggcaaaa tccagtcata tcaaggactc aaccgtaatt
      541 gcgaaaatcg cagacaatct attctattct aattctatag acactaatag acacataata
      601 gacactgaaa ctgaccagtt acaaaatcaa gttttgctag ataacttcgt cgacatcatg
      661 caagaggaca gtataaatac atttgtacca gaaaatgtat taaacttgat aaaaacattt
      721 tcttcaagtt acagtgaagc tcaacaaacc gtccaaacta ttcataatgc aaagaaaaaa
      781 gctgaagaat tagagcaaac tattgtcgtt tatgaagaac tggaatctta tggaattgat
      841 gctgacaaag gattatatat gactttactg aaagcttatc aaaaacaaaa aactgaaaaa
      901 gtaaacaatt tgcagaatct aattttcgtt tatgtaaaaa attggtttgt cgaaaaagct
      961 attgcggcaa agcttgcaaa cgaacaaaga gaaacattta acgaattacc aacagttagt
     1021 acggaaaatt ggttagagta gttgataaaa agcaattact ataaaaatga tcaattttaa
     1081 attagaactt ttttatgatt ttaattttat tacaaatatt acaaataaat agttagtatt
     1141 ccggagtttt tagattaaaa gtttatgaaa acaatcacaa tcgtaggttt taaattcata
     1201 atcgttagat attttagtta tttttcactc aaaaaaatag ggaactagtg tttgcatatg
     1261 tgcttttttg agttataata attcatgaag agaggtaatt cacttatttc cccaagctga
     1321 aaagcctgat attacttctt ttcaggcagt gctgctaata ttcaattaca cttttttgta
     1381 tatttttagt tgttttaaat ttaattgtct gctatgcttg tgatgaattg attttcgttc
     1441 tgcacttttg gacgataaat ttggacaatt gaaaatacaa aaaaaagaaa ggccctgtga
     1501 gactcggaag gctggtaacc ttcgtcgacg tccacaggtg gcattaagat cactccctta
     1561 atgcgtttac ctttcagtgt tacggtatta cccgtaacgg atttagggtt ctgttgcaaa
     1621 gttttaaata aagaataaaa tcccttacgg tatctatgat ttaagctggg attcccaata
     1681 ataccttgat ttcagtacag accgaaaacc cgaagagagt gccttctttt cgggttttct
     1741 tatataatcc tcgaatggct tccatgcctt taatcgtggt agaggcagtg cgtaaacttc
     1801 gatagaattt attgcgtctc tttactggac gatggtcttg ttcaatcaaa ttattcaggt
     1861 atttaatggt acgatgttct gtcccttgat aaaagccgta ttcttttagt ttcttaaagg
     1921 cacttgtaat agagggggct ttatctgtga ctacaacctt cggttcatca aactgcttca
     1981 ctaaccgctt aagaaaagca taggctgctt gtgtgtcccg ttttttacgt aaccaaatat
     2041 ccaaggttaa accatctgca tcgatggctc gatacaaata atgccatttt cctttaattt
     2101 tgatgtacgt ttcatccatt ttccatgaat aaaaggattt tttatttttc tttttccaaa
     2161 tttgatagag tagtttgcca tattcttgca cccaacgata aatcgtcgta tgagaaacgt
     2221 taatgccacg atcatataag atttcttgaa cttcacgata gctaaggtta taacgaagat
     2281 agtagcccac ggctacaata atcacatcct gctgaaattg ctttccttta aaatgattca
     2341 tcgtcattcc tcctgctatc tttttctatt attctacctt atttgatagt agatttaaaa
     2401 ctttgcaaca gaaccaaaga aaatctaact tttttcaaac cacgatcttt catacgagcg
     2461 cataatgcaa aaaataaatc catctgctta gcattgaaat ttttcagcgg tactaaattc
     2521 aattcatttt gatatttgac tgttaattcc gttttttcat ccattccttt cttcccccct
     2581 tacaaataaa taataacctt taacaaccaa ctcgtaaata ggttggttgt tattatacaa
     2641 aaggatatta gtactcagat aaaaagttgt tagtactcag ataaaaagtt gttagtactc
     2701 agataaaaag ttgttagtac tcagataaaa agttgttagt actcagataa aaagttgtta
     2761 gtacccttct gtatccgttg ggagagtaag gctcaactgc cccctaaaaa gggttctaaa
     2821 aaatctttaa aaaataaata aaataaacgc gcgcgcgcga gcaaaatttc ccgccaaaaa
     2881 atcacccact ttttaaaata aacaggttcg cgcatgatat taaactgcca atctagctcc
     2941 ctatggtcgc tgtaagaagg agtgatcgct acgctctcac attttacttg cagcagtcgc
     3001 ctttaggctc cttcgccaaa aataattcat tagggactcc tttgtggcgt cctgagagct
     3061 cgtctaagcc gttctaagac aagattcgat aaaaactatg tccttcgttc taaagcgcct
     3121 tacaggcggt cagggcaagc cctaacaacc ccaaggcaat aaaaaactta ggcttatttt
     3181 tgctttttta ttgtataatt gattgtcgcc tatccgacag tcttgcgact ggaaggaggt
     3241 gtgtttcgtg ttcactaact ttatttgctc ccttcttgtt gggcttttaa gcgctttgtt
     3301 cagttactgg ttgaataacc gaaacaagaa gtaaaactta attaaggcga ctcagcccac
     3361 aaaaaaagcc ccagagaatc cgacctctct ggggctttcg tgtgtttcgt gttcacttat
     3421 ttgcaatcaa attataacag aaataaatat ttatttcaaa aatatcctac aaaagtctaa
     3481 aatccgtaat tatttcttat atgcaacatt tacaaataaa gtcgctctga gagctcgtat
     3541 ttttcgattt aagacgtttt atttagtttt tggtgtattt cattggtcca agctaaaaaa
     3601 ctcttagaag cgattttaga gccatttaaa cccacttaat tatattctcc atgaaattcg
     3661 ctccatgcgt caaaagctgc gtctgaaatt ccgccgtctt cgttcactag ttgcattaat
     3721 ttttccaacg atcgttttct ttcgggtgtc atatttttat attccaacaa tttttcgtct
     3781 gttaaatcga acttgattgc ttgaattgct tgctctaatt tttctaagtt ttgaaaatat
     3841 tcgtaaggaa atttttccat tttttctttc tccagtctca caatttttct agaaataaaa
     3901 tcacttcttt gccgtctata ctctcaaaaa aaatgtcgtt tgaaaaacta aataaatttt
     3961 tgatcgtgca tttttaaatt tggttatcga ttacacgtgc agcactcccc cccgaatttt
     4021 aaagagcata aggaaacgtg tacccacttt ctaaaaaaag tgggtagata ggctgtgcct
     4081 atcacgtttc tcagaaaaaa atttgatatc actttttcgc catcgtgggt agcttatgta
     4141 tagcattttg gcaaaaaaca gctatacaaa tatagtattt gtatggtata cataaattat
     4201 acataattgc aaaaggagat tttttatgga cattttagtt cggaatattg atccaaagtt
     4261 tgttgcaaca atagacaaac gttgccaaga actcacgaat aaaacaggag aaaaatggag
     4321 tcgaaataaa tatctaaaag ttttaatcga aagtgatttt gaccgtcaac ttacgactta
     4381 caaaaaagac caattcgatt tattgctcga taaatttatt gctatccaaa cagaaaatac
     4441 tcaaatatta agcgagtatg tctacacaaa taatcaaatc attgaaatgc ttatcggagg
     4501 aatgatataa ccatgagaaa aacttctgtc caaaaacatg ttactttgta ccctagtcat
     4561 gttgacgttt tagattccat catcgaaaaa aatccagata tcaataacta ctcggaagcc
     4621 attcgctttt tatgtatgag ttatgaaccc gataccaaca cgaccactac cagcaatcag
     4681 gcaaaactaa atgctatggg aaaagaaatt tccatcatga ctgaaatcat cgcagaattt
     4741 gctgatttat atctaaaaga tacaggcgtt cttattggca caaattctaa agtatatcaa
     4801 gaagtgaaag aaaaaatcga agctaaacta aatccatcaa atcgaaatcg accaaagaat
     4861 catcaaaaag aaaccagtca aacagtcact tctagaaatt tcgacccaac aaattttcta
     4921 aaacgataaa aaacagatag gagttattcc tatctgtttt ttatttagaa gccccataca
     4981 atatgctaga atgtactagc aatcttagtc ggttgtaagg gacttgtcta cttgcttaat
     5041 gtaagggggg cgagttcttt tttatttatt cttctaacca gttacgcaga gaaatctttg
     5101 gcaaatctga cgttaggctt gaaaaagtaa attctaattt ggcgatttta ttgccctttt
     5161 ttgcttttat ttttgtgact ttaagatcat tgaagtattt ttttagttct cgtaatgcag
     5221 gatttaatac tttttgatca atgttaccca tttgatagta ttctgggata tccattaagc
     5281 tcctaaactc ttcaatacga actacataat aaccagtaga acggtactgc ataagcagtc
     5341 ggaatagagt ttttgcatac gtagaacgca acgacgtgaa agcagataat tcaaatctac
     5401 taaattcagc tgttaaacca ttaataatat attctaggtc cggattaaca ctgacttcaa
     5461 caaacttttt tgttttattg atttcaaaac cagtaaacaa aacaaagtag cgaatagaat
     5521 cctcatcttc agtacggtaa gtaagattaa gcatatcggt tctgttgcaa agttttaaat
     5581 aaagaataaa atcccttacg gtatctatga tttaagctgg gattcccaat aataccttga
     5641 tttcagtaca gaccgaaaac ccgaagagag tgccttcttt tcgggttttc ttatataatc
     5701 ctcgaatggc ttccatgcct ttaatcgtgg tagaggcagt gcgtaaactt cgatagaatt
     5761 tattgcgtct ctttactgga cgatggtctt gttcaatcaa attattcagg tatttaatgg
     5821 tacgatgttc tgtcccttga taaaagccgt attcttttag tttcttaaag gcacttgtaa
     5881 tagagggggc tttatctgtg actacaacct tcggttcatc aaactgcttc actaaccgct
     5941 taagaaaagc ataggctgct tgtgtgtccc gttttttacg taaccaaata tccaaggtta
     6001 aaccatctgc atcgatggct cgatacaaat aatgccattt tcctttaatt ttgatgtacg
     6061 tttcatccat tttccatgaa taaaaggatt ttttattttt ctttttccaa atttgataga
     6121 gtagtttgcc atattcttgc acccaacgat aaatcgtcgt atgagaaacg ttaatgccac
     6181 gatcatataa gatttcttga acttcacgat agctaaggtt ataacgaaga tagtagccca
     6241 cggctacaat aatcacatcc tgctgaaatt gctttccttt aaaatgattc atcgtcattc
     6301 ctcctgctat ctttttctat tattctacct tatttgatag tagatttaaa actttgcaac
     6361 agaacccatg taccgaaatt gtgcaaaaaa ccttcccgtc acatgacgag aaggtcttaa
     6421 tcattttaat agtcaaattg acggtagtag cgccgaattt ccaatggatg acaatttaat
     6481 ttttctacat gggcatcaat ccgttgggtc acacaatgca ttaataagaa tgataataca
     6541 cgtccacgat atttttcact gattccttcc acagcataat cttttgagtc aatgaaagta
     6601 tagttgccac aaatacgcgg taataagttt ttcacgcgct ctgctaaggg acgttgttca
     6661 tcttctccta agaaaagtgt aaccggtgtc gtttcatcga caatttctaa tgtaccatgt
     6721 aaaaattcag cagcgtggat tgattttgaa cgcaaccagc tttgttcttc ccaataacac
     6781 atcgcatatg agtagacagc gccccattga ttccccgccc caatgaaata atgcatcgca
     6841 tcatgacggt gtttttctgc aaattccaaa ccaaaagcat ctgcttgttt ttccgcttca
     6901 actaaacctt tggctaaatg tccttctagt tcttgataat aatcttcata gtcgtcaaat
     6961 tcaccattat ttttcattag acggtctgcc accataaaga atttgatttg ttctgttccc
     7021 ggagctggat aggtaataac ataatcacat ttttcagcta aggggctgtg ttcagtgtcg
     7081 ataaagccaa ttaaagttgc ccctactgtt ttaatttcat ccactgcttt gaccacttcc
     7141 tgggttgtgc cagtgacaga agataaaacg acaattgaat ctttggttag gcgtttattg
     7201 ccggttgtat agtattctgc tgcatgttgc acgtaagcag gcaaattact tttaccattg
     7261 atataagtta cagcctgcat tgcagatgca taagttccgc caattcctaa atagtaaata
     7321 ttgtcaaaac ctttttccca cacgctgtcg ataatttttt ctacttctgg gcgtaagtct
     7381 aatgctcctt gaatatcgtc aatttgtttt tgttcgttaa attttaacat ttttccacct
     7441 ctatcattta cttttacact ttacttttta gtacttgatc aaaatcatca aaaatccgct
     7501 ggcttaaatc aatgcctttg gcagtcgcaa ttttatatgc caaaatttgg aaaggaatca
     7561 ctaagagtaa agatgaaatt aattcgtcac actctatagc caaacctaac tctgtttcat
     7621 ttttggtatt ggcagttgtt accgtaatcg ttgttcctac gtaaggattc atatagtttt
     7681 ttaaactttg ggagcgcgct tcattcacac tttttgtttc aataaagaat aaaatatgct
     7741 cgctatctgc ttctaaataa gggccgtgca tgtaggcttc tagttcaaaa ccttgcgaag
     7801 gtttgcgaac cgtttcagta aattttgttt caaattcctt tgcagttccc cagtttggac
     7861 catagccaat ggcgataaac cgtgtgccta gtttaaaaat cgcttcgtga accgtaaaga
     7921 aattgttcgt tttttcaatt gtatcaggaa tggctgcgat cactttttta agttcacgtt
     7981 gataataatc caactgtctt tgacttaaag tttgtttatt gtaaccaatc gttaagccta
     8041 gtaaaaacag ttgaagcaca ctcgacacat agccctttgt tacaaaaccg actttttcaa
     8101 ttcccatttc aagatcaatt acttcatcta ctactgtagc aatgggacta gaaacatcac
     8161 tggttaaggc taaagtaaat aatccttctt tttttaattt ggcaatagcg tcaatcgtag
     8221 acgcactctt gccactttga gaaactgcca aaacagcatc cacgctattt gaaatgcgac
     8281 cataatgatt aaagttatac ggttcttcaa tcgtgatcgc gatatcggca aatttttcta
     8341 aagtaacttt agctgctaag caggcattgt aagatgaacc ggtggctaag attaacagat
     8401 tgttgatttt ttcatagcct gaaacttttt ttaaggaaaa atccgctaaa atattttgca
     8461 gtgtcgcttc ttcttcgttg atgtaatcca acatcgtttc catccattac acctcctaga
     8521 aaatgcctac taatgaacct aagattccta ccacagctaa gcctaaaaga atcgttaatg
     8581 gcttcacttc ttttttcaat agatagaaaa ctgcgccaaa aacaccaaga cataaaattt
     8641 tcggcacaat atcatcaaaa atactttgga cggtgacggc attttctcct gaaccaattt
     8701 tcattggtaa gttgatatca atcatagttg cagtcatgcc tccgaccacc atcaatccaa
     8761 taatcgacgc acctaaagtt aaactttcca tcatcccgtt ttcttgaatt ttctttaaaa
     8821 agcccgtccc taatttatac ccccagctgg ttgccaagta gcggaataaa atatgcggaa
     8881 tattgaaaat caacaagaat aaaatcggac ctaaaatatt tccttgtaat gccagagaag
     8941 ttcctacacc tgtggcaatc agacgtaatg tgccccagaa aaatgaatcc ccaatccccg
     9001 ccaatggacc catcaatgat gttttaatac tgtcaatggc agaagtatca aaatcaggat
     9061 cattaacatt ttcttcttcc atcgccgcat taatccccaa aattaaggtc acaatatgtg
     9121 gcgtcgtatt gaaaaattct aaatgacgtt tcagcgcatc ggccatttgt tctttggttt
     9181 gatacaattt tttcaaaatt gggatcatcg cataggcata tgccatattc atctgacgct
     9241 catagttcca agaaaactcc atttgaaacg agcgccaaaa tactttgctt aaatcctttt
     9301 tagtgatttt taaatccgta ttagaagtct tcgtcatcat caactacctc ccctgtagtg
     9361 gcttgaactt gtggagcctg gttgctacgt acattcataa tgttgactac gacaactgcg
     9421 acaatcgcac caaaaatggc aatcccagta acaggaattt ctaaataagc tgctaatgca
     9481 aatcctaaga agaagtatgg tgccaccttt ttattaatta ataaacgagc caacatcgca
     9541 aaacctaaag ctggaattaa accagttgcc accgataacc cgtgttgtac gaactctgga
     9601 atcatcgcta gcaaattccc aatcgtttta cttcccacca taaaggaaat catcacgatt
     9661 aacccaagca ttaaagataa accaaagcct gcacataaat gcatccgctc aacgccttta
     9721 taatttcctt cagctgcata atcgtcggct ttgtggttca taatcgggat taaaagtccc
     9781 aaataaatat ttttcaaaat caaagttaat gttgcaatcg gtaacccaag taataacgct
     9841 gtctcggtgc ccgctcctgc ggtaatcgca aaagccgttc ccaagatacc accggtcacc
     9901 acatcaggtg gaatagaagc acccacggaa aatgaaccaa taaatgctag ttcaagagtt
     9961 gcacccataa taatgccggt ctttatatcc cctagaacga tcccggtaaa taaacccgtc
    10021 acaattggtc gggacaaaag tgaagtccct aatgcatatt ctgattgtgc aataaaagcg
    10081 acaatgccta ataaaattgc ttggacaatc attttttcac tacctttctt ttacaaaact
    10141 tctgtaacgt tcaccttttt atcatttggt acttgacgaa tttcgacttc cacaccttga
    10201 tcaactaatt ttttcaaaag ttcttcttct tcaggtaata cattcactgc tttaccaatg
    10261 ctgcgggtac cttctttgac ttttgtcccc ccaagattga tttttttaat ctcaggataa
    10321 gcttcggcta atttgtaggc atcgccaaca gattcaacta caatgaatag tttgtattta
    10381 tctgtcacac cactttgtaa agcggcaata gaatcagcaa tatttttaat taccaattta
    10441 acaccttgtg gcttggctaa tttaatcgtt gttttacgaa cttcgttatt tggcacatca
    10501 tcattggcga ttaaaatgca atctgctcct aaactttgtg tccaagaaaa tgcaacttgg
    10561 ccgtgcaata accggtggtc aacgcgggtt aaaataatca tttttcttct ctcctctttt
    10621 taaaaatctt cttctgctac agttgtttga tacgttaaat tacaaaactg aatggcttct
    10681 tttgagctgt ctaaaacgct cgtaatcgtt gtttttaatt ccggtacaaa tgcaaattgc
    10741 gttgcaaatt caattagaaa tggtaaattc atcccggcta ctaagtaaaa atgctcacga
    10801 ttaatgtagc gtaaaaattc gttattgacg ctgccgccaa ataagtctgt cacgacgacg
    10861 acttctgtcc cttcattttg gtgcatcagt tcatcgacag ctttagtcaa atcgaagtct
    10921 tctgttatgt aacaatccaa agtcgttata ttgtcattct tgccacagat taattccaat
    10981 gagcttaaaa tgcccgaagc aaattttccg tgggaagcta aaatcatttt tctttccatt
    11041 tccctcacct catttcctac accaaaataa aagcaagttg cgtgccaact ttagtggcag
    11101 caacttgctt ttattaaaaa tcttcatcaa ttggcatatt gtcagtgttt tgatagacaa
    11161 tatcataaat atatgcaatt tcggaatcag gaatcttgac actgtaatca ttttctatga
    11221 cactaaacgc atttttgatg gcaactaaag ctgttttttg acactggtat aacaattcat
    11281 aaccagcata ggtatcaatt ggaatattgc gaataaggcg ctcaattaaa caactgacgt
    11341 gaacgtacag cgccaacttt ttggcattgc tgataacaag tccgctattg gcttctagct
    11401 cccgcataaa gatttcaatt tctcccatta ctttttcagt atctaaaatc gtcacggaat
    11461 caatgacttt ttctaaagaa aaattgcgga taacattggt gttaaacgtc gcattttcta
    11521 gaggggacaa acaagtactt aaccattcgg ataataactg attttcatca ccagaaatta
    11581 actcttctaa agataaataa ggaatatctg caatctctgg gtcagaagtt ccgataatgc
    11641 ctaaaacatc atacatggaa aaaattgttt catttttctt ttgttctttt aatacgtcat
    11701 attcgtaagg aaaaattttc agttctactg tggcaggtaa acttttttct aacagctgac
    11761 tgatatgcgt cgctgtccca attcctgtta aacaagtggt tattaaggcc ttcattttat
    11821 tttccgccgg ataaattatt tcccaatcca acggtgcttg ttgcgcagct gtctcaatca
    11881 tttccgctaa tggtaatgct ttttgtaaat tttctcccat cgcaatggct aaaggcgtcg
    11941 tgacattatt cataataacc acaggcgcag taatttgttt tgggaaaaac tgataaattt
    12001 cttttaatga ccccatatct actaaaatga ctaaaccatt ggaaacatca tggttctcac
    12061 tgtaatccaa aatttcttca gcaatttgct gcggggtgac atctagtggc atatcaaaag
    12121 aagcgaagat atcttttgct aaaaaacgat tcgcaacgtt tgcaatacta ctggccgtgg
    12181 cataaccatg agcaacaata atacctctgg ggatacccaa ttctttttgc caatctgccc
    12241 gatttaaata aatcgtcagc aaaatgcagt ccatctccga aatttccaaa tccaattttg
    12301 gttggcacaa ttccaaaaga cgtttgacat attgatagct cgctgcgtat ttggttgcta
    12361 cttgctgttc taactcttta attaacccta aaattgccac atcttctgga taccacttgc
    12421 ccgctcctcg ttggaataaa tagtaactaa tcgcataaac cgcattgccg ttaaatttga
    12481 tttgataggc actttccatt tgtttaaaag tatccctgat atattgggtt aaataaatca
    12541 gcatctcttg tttttgctgg cgatcagttt caaaaagtaa aaaatcaaat agtgtttcaa
    12601 cttcttgttt taattgctct tcacaagctg tcagctgttg ctgtttagaa aactcggtga
    12661 taatccggtc aaaagtcgca atcacccgtt gttgttgagg atgatttttt tctaaaagtt
    12721 gggtaatcgt cgtattttcc gtgattactg tatctttttg gagcacggtt tgaagatttt
    12781 ctgttgccgg taatagtaat ttttccggta actgataaat tgtaacttta atctctgcgg
    12841 cttgcttttg ttcggcaaaa gctttcgcta cggtgacctt gaccgtattt ttcaactctc
    12901 caatattgcc tttaaagctg ctactggtaa gcagagttaa gacttgacca ctaactttta
    12961 gtggtcgttt aatttttcgt acttcactta ataaaaatga ataaaccagt tccaagcgct
    13021 cattgcgact gcgggcatta atcggtggaa gtgtcacttg aatgggaatc cggcgcataa
    13081 aagtcgttaa aaaactactt tccaaatctt ctgtcgtggc aaaaaacaag cgcgttttca
    13141 ctttgattgg ttgattggtg gcccccatgg gataaatgat gccctgatcc agataagtaa
    13201 agagcttttc ttgtccttct gcattcaagc gatgtacttc atctaaaaat aaaattcccc
    13261 catctgcggc ttcaaaagca ccaactttgt cactgtcagc accagtgtaa gcacctttga
    13321 catgtccaaa cagattactt gttaaaagtt ctggattatt agcgtattgg gcgcaattta
    13381 gcgtgattaa aggcgcatct tctttaatta attcattttc cagacaatat ttatgaatca
    13441 gacggactaa aaaacttttg cccgtgccgc tttcaccggt gattaaagtc ggtaagccgt
    13501 tatctggata ataaagagcg gttttaattt gttcaacggc acgagttaaa cttttatcat
    13561 ggccaattaa aagcgaaaat aagtcttttt gctgctcaaa taaaggttgc tcctttaaaa
    13621 tttcttcact gctttgataa aaattgtccc gcaagaagaa aaattccttt tcaaaagctt
    13681 ccttatgaaa ataataaacc ggtcgcgaat taattttcac taaaattccc gcttcattta
    13741 attggtttaa atagtggcta atggtattac gcttcacctc aaaaatttcg gctagttttt
    13801 gggcggtaaa aacttcactt aaatggtgaa gatcaataaa agctgtctga ttttccaaat
    13861 atgttaccaa ttcttctttc attattatcc ccacttattt tctttactgt tgttttaaac
    13921 gttttcagtt ttagccacaa tgtaccacaa aaaaagacag aaacttaact agtttccccc
    13981 tttttttagt gaatattaat aaaacaatat ataatgttat gcaacttctc tattcattaa
    14041 aaaattgcaa tagtaggtca tacacatctt ctttttggta ctcgtttaat acttcatgtt
    14101 tcatgccggg catttctaca ctcctaacat tttggtagcc aattttattt agcgttgcta
    14161 ttgtatcagc caagcctttt ttaccacccg taattttgac atcttctgcg cctaccacac
    14221 ttaatattgg taattgtgga ttgtgacatt gaaaagcggc gtagtttttt aactgatagt
    14281 ccccttccca aattgtcagc aggctacgca ctggataaat cggtaccatt ttttcatctt
    14341 gttgacattg taaattattc accggattat tacttagcca atcatgttct actcccatgt
    14401 tgccagaaag ccaatttaat aatttatttt gcttatcttt ttcattaaag cgtaaaaata
    14461 gtttaccagc tgcaatgcct aaaggaacaa caggaacata atttgctgtt ccagttaatg
    14521 caactttagc gatacggtcg tcattttttt gtaaataatt acgcgcaatg atcgagccaa
    14581 aagaatgacc aaataaataa agcggtaatg ttgggtattt ggtttggata aagtcgctaa
    14641 taatggttct gttgcaaagt tttaaataaa gaataaaatc ccttacggta tctatgattt
    14701 aagctgggat tcccaataat accttgattt cagtacagac cgaaaacccg aagagagtgc
    14761 cttcttttcg ggttttctta tataatcctc gaatggcttc catgccttta atcgtggtag
    14821 aggcagtgcg taaacttcga tagaatttat tgcgtctctt tactggacga tggtcttgtt
    14881 caatcaaatt attcaggtat ttaatggtac gatgttctgt cccttgataa aagccgtatt
    14941 cttttagttt cttaaaggca cttgtaatag agggggcttt atctgtgact acaaccttcg
    15001 gttcatcaaa ctgcttcact aaccgcttaa gaaaagcata ggctgcttgt gtgtcccgtt
    15061 ttttacgtaa ccaaatatcc aaggttaaac catctgcatc gatggctcga tacaaataat
    15121 gccattttcc tttaattttg atgtacgttt catccatttt ccatgaataa aaggattttt
    15181 tatttttctt tttccaaatt tgatagagta gtttgccata ttcttgcacc caacgataaa
    15241 tcgtcgtatg agaaacgtta atgccacgat catataagat ttcttgaact tcacgatagc
    15301 taaggttata acgaagatag tagcccacgg ctacaataat cacatcctgc tgaaattgct
    15361 ttcctttaaa atgattcatc gtcattcctc ctgctatctt tttctattat tctaccttat
    15421 ttgatagtag atttaaaact ttgcaacaga accatatttt ctatgtcctt tttattccat
    15481 tttgtatcaa taactatgaa atctttaaag tatccagaag agattatttt tagatcaatt
    15541 tttttcttac ctgattctaa agattttgtt ttcttaaaca tattatgatt tcctttcgac
    15601 tattttcata taaatgttaa catagtttat ggattcatgg aatgttaatc taatttaata
    15661 gaaaaggata attaagtata tacgtttttt cttatgtatg ttatactatg tatatacaga
    15721 aagaggtgtc tactatggaa atgttaccta taaaaaaatg gggaaatagt aatggcctta
    15781 gattgccaaa gtatattatg gaatatcttg gaattcatac agaagacaaa gtgaagataa
    15841 tacaagaaga agtaaacggt cagaagcggc taattatcga agcggctaat atagaaaatg
    15901 aattaacaat tgaacagtta tttgaaaatt acactgatga aagaaatcat gtgacgattc
    15961 aaaatttagg tgaagcagta ggtaatgaaa aatggtgaga aaacctagac aaggcgatat
    16021 tctattattg aatacagcac ctcgatctgg acacgaacag acaggtaaaa gaccttatat
    16081 tgttttaagt catgatatta ttgcggatta tagtaacgtt gttacagttg ctccaatttc
    16141 tagtacaact agaaactatc cgctatatgt aaatataaac tcagaatatg aaatgaagac
    16201 aacaggaaaa gtattattag atcaactaac gacaattgat tatgaagcca gagagtgtat
    16261 ttttttggaa aaagcgcatg atagtttagt tgaggagtta ttgatgaaag ttagaacagt
    16321 ttttcaaaaa gtaagcaaat aaaatagaaa cagcagcatg atcaactatt cgtgattgac
    16381 catgctgtct ttttttattc tatatacggt ttgtctcgta acattgtagt cttttgcaat
    16441 cttagcgatc gcaacacctt tttttagatc ctcaacgatg tttttataaa caagacgacg
    16501 ttggggatct tttgcattgg cactgtatag cttaggacgt cctttataaa caccgttcgc
    16561 ttttgcaatc ttaatgcctt gtgcctgacg tcgtttagat tcggtacgtt cttgttcagc
    16621 gatcatggcc aaaatttgaa tgatcaaatc tttaatgaat ttatccagga gaggattgcc
    16681 aattgcttcg gccatgatcg gtagacttgt gatgatcagc tgcacatttt tcttcttcaa
    16741 gtaattgact gaagcgatga tctcgtcgta atttcttcca agtcgatcaa tagcttccac
    16801 aataaaaata tcttgatctc ggacgaaatc cagtgcttct tgaaaaacaa gtcgatgagt
    16861 aatcgttgcg ccagattgtt tctcaatgaa aattctctct gcaccgaatt ttttcatttc
    16921 ttcaatctgc cgttgttcat tttgatcgat ggatgagaca cgtatgtatg caactctcaa
    16981 aatttttacc tactttctgc aactatttaa aaaacaccct aatcatacac gagaaaacca
    17041 gatttttcaa tgtcgcggtc gtgtctagtt agggtatacc ttatatagac aaaaactaat
    17101 gatggaggaa atagtatgtg tcacttttct ttttaaatgg caatattttt tgtaaataaa
    17161 tgtcaatcaa gaaaatttaa acgattatga cattaaaaat atattttatg aattttctag
    17221 tatataactt gatttatctg ttaagattta ttaagaaaac gttttcttat ttttgatttc
    17281 gaggtgatag acaatgaaaa ataagtttat tttatcttta ggtattttaa ctattggaat
    17341 tagtgtaact ggaactacaa ttcctacatt tgctgatagt acaaatgaac caactactgt
    17401 agtagataat aaccaagaat taactccttt agataggaac ggaatagcca ttggtaaccc
    17461 aactaacgac ttaactgtta ctgaaaatta tttaatagtt tctccattac ttgctcgagc
    17521 agcttctaaa acgatacgag tgacaggaac gatgattttt gataaagttg gttggccttc
    17581 tagacctcct caatcacgga attggaaaga aaaaagaaat ggttattggt actatggaaa
    17641 attgtattta caaagttata aatcagctgg aaacaattgg attgcgactt attcaggaac
    17701 cttaactaga aagtagggat tttttatgcc agaatttgtg aacacaccaa atttttatca
    17761 agatagcgat attctaagta aaattaattt accgaaagaa gaatcagctt tacaagttca
    17821 gcgaacttta caggagacac aaaaaattca aaaatcaatt tctaatctag aagattctga
    17881 agaaaaaaga aaaaaaagag accaaaaaac atatcaaaaa gaaaaataat gattttaaaa
    17941 aaagagtgtc tagtcgacat tctttttttc taattgaaag tgttcataaa atcacccatt
    18001 tctggacact ttcttttttt gctttatttt tcaaaaaaac aattcatttc atgttcataa
    18061 acccataaca atatctatgt tcagttaaac tatatggata aagttatgtt acaataaaat
    18121 taatgaagga gtgatttttt tgaaaatagg atacgcccgg gtatctactg gtttacaaaa
    18181 tttggattta caagaagaca gcctaaataa atttggttgt gaaaaaattt ttactgatca
    18241 tatgagtggg gcaaaaagta atcgaccagg attagaaatg gccattgatt ttgttcgctc
    18301 tggcgataca cttgtcgttt ggcgcttaga tcgtttaggt agaaatatgg aagatttgat
    18361 ttcaatcgtc aatcgactga atgagcgtgg tgtgagtttt catagtattc aagaaaatat
    18421 tacgatggac aaatcaagtt ctacaggaca gctcatgttt catttgtttg cggcatttgc
    18481 agaatttgag cgtaatttga tcctggaacg atccgcagca ggacgagcag ctgctcgtgc
    18541 aagaggacgg tttggtggtc gtcctgaaaa attgtctgaa caagatttgg aattactgaa
    18601 gactttagtg gatagcggta cacctattaa gactattgcg gaacggtgga acgtctcaag
    18661 aaccaccatt tatcgttatt tggcaaaaat ggaggagaaa aatggaaaga caaattctca
    18721 ttagtttttg tcatttaatg ctgaaaattt ttgccattta tctagaaaag tgacaatagt
    18781 atgagaattt tttgtaagtg tctactgata acttattatc aaatgttgta aggattttat
    18841 tcatttgtta atattaaaga acggaactcc aaaaaagtcc gtactctaat ttgcagtctc
    18901 tcactctttt agagtgagag tttttattag attttcaaat taattagtaa agtgatagaa
    18961 taaattgatc atacaaatca taagaagaag cagggtgata gcatacctat gcttcttttt
    19021 ttatgtattt agctatttct tctttacaac atcgaacata tgtttgtata atgtggaaga
    19081 atggagtgtt atttatgatg gattattcaa aagagccagt aaatgattac tttttaatcg
    19141 atatgaaaag cttttacgca agtgtcgaat gtatagaaag aaatttagat ccattaacaa
    19201 cagaacttgt tgttatgagt cgatctgata atactggttc aggattgata ttagcttctt
    19261 ctcctgaagc aaaaaagcgg tatggtatta caaatgtgag tagaccacgt gacttaccac
    19321 aaccatttcc taaaacacta cacgttgttc caccacgtat gaacctatat atcaagcgaa
    19381 atatgcaggt aaataatatt ttcagaagat atgtggctga tgaagatcta ctgatttact
    19441 cgatcgatga atcgatttta aaagtgacaa aatcactgaa tctttttacg actgaagaaa
    19501 cacgaagtca gcgaaggaag aagctcgctc aaatgatcca agaacgtatt aaagaagagt
    19561 taggtttgat tgctacggta ggcgtcggcg ataatcccct tttggctaaa ttagccttag
    19621 acaatgaagc aaagcataat gaaggattta ttgcggaatg gacgtacgaa aacgttcctg
    19681 agaaagtatg gaatattccc gaaatgacgg acttttgggg aattggttct cgaatgaaaa
    19741 aaaggctcaa ccaaatggga attttgagca ttagagacct tgctaactgg aatccttata
    19801 cgattaagaa tagattaggt gtgattggat tacagctgta cttccatgct aacggaatcg
    19861 atcgaacaga tatagcaatc ccgccagaac cgacaaagga aaaatcttat ggtaattcac
    19921 aagtgttacc acgagattat actagaagaa atgaaatcga gctggtggta aaagaaatgg
    19981 cggaacaagt agccattcgt atcaggcagc ataattgtaa aacaggatgt gttcatttaa
    20041 acattggtac gtcgatctta gaaacgagac caggattttc acaccagatg aaaataccta
    20101 tcacagataa tacaaaggaa ttgcagaatt attgtctttt cttgtttgat aagtattatg
    20161 aaggacaaga agtaaggcac gttggaataa cctatagcaa gcttgtgtac accgattcgc
    20221 ttcagctgga tttatttagt gatccacaaa agcaaattaa cgaagaaaat ttagataaaa
    20281 ttattgacaa gattcggcaa aaatatggtt ttacgtcgat tgtacatgct tcttcaatgt
    20341 tagaaagcgc tagaagcatt actagaagca cacttgttgg tggtcatgcg ggcggaaatg
    20401 ggggaattaa aaatgattga ttacaatgat cgtggacgtt taaagtgggc agggttttat
    20461 ttatctgatc atactgaaga aattgatgcc gacaatgaac aacgaaccag tcaaaattta
    20521 gcaaaagaac aaatgacgac tgaagagatt gcggaagtat tgaacgctgc agtcataaaa
    20581 aatagatcag tatctattca aaaagaagaa cgaaacgctg aaggatacta tccagaagat
    20641 attgttggca agatcttagg tagtgatgag ctggggatct acgttggaaa agacaaaatt
    20701 cactacgacg aaatacgtca tatcgaattt taccaggata ataaatggag tcgattagaa
    20761 tgaacattat ccagcaatat gagctaaagt atataacctt tgatcagcta tcagaagaga
    20821 tttggggtta tggccaacgt ttgataaatg aggttggtgt tgagcgcttc tctttctatg
    20881 tagaagctgc agcaggttat cataatttta ggttttatat tttcccgtta tatatataag
    20941 gtattttacg gattctatag agttatctct atgaatcctt ttttgttttt acaaatagga
    21001 gtagatacta gaataatgcg tgtgttaaac tattattgca aacgcaataa taaaagaaag
    21061 taggcttacg caccatgtct atcaatacat ttgtttactc gcacccgatc aatgtttaca
    21121 ttatcaagaa tttaggaatc actgtagaac aattttgtga gttatatgcc tacccacaag
    21181 gaacggttgc aagctggata acccgacaac gtagaataaa atcattacct gcttcattcg
    21241 tttatgattt aagcctggcc tctagtttaa acatgtctga tgtttatgaa aagctcctgt
    21301 ctttagaaaa agaatatgat tccttcaaga ttaaacatga taaaaaaata aaaaaacata
    21361 tataatatca atcacaattg tataatatta cgatatctta atatcatgat atcgtaatat
    21421 tgtttttttc taagaaaatg cactataaga agggaattat tagtaacaat atagacagtt
    21481 taataatgtt taaattattc tagttgctgc tcgcaaaaca tatttcttat gattaataaa
    21541 aaattttaaa gtaataaaaa gtgattattt tactttcgaa taacatatga ataatcttta
    21601 tatccgaacc gatatatatc tttaaaacaa aataatcaca caatattaca atataatgca
    21661 tatacgatat tgcaatatca caatattatg atataattat attataatat aagatgaatg
    21721 ggggatattt taatggcaag aatattgtca gtagccaatc aaaaaggtgg agtttctaaa
    21781 actacgacta gcgttaattt agcagcatgt ttgaaatttg tttacggtaa aaatgtactt
    21841 ttagtggaca ttgatcctca gggaaatgct acagataatg taggtttcga tatagatgga
    21901 acaaaccaac ctacaattta tgaagtatta aaaggggagg ctgacattac agatgctatt
    21961 ctggactata aaggaattga tgttttgcca gccgacatag ccctttcttc tgcagagagg
    22021 gaatttactc aagtaggaag tgaacacagg cttaaaagag tacttcaacc aatcaaggac
    22081 aactatgatt atattataat tgattgtcca ccaagtttag gaatgcttac agtcaacgca
    22141 tttactgttt ctgatgaaat tatcattcca gttgaagctg cgtatttctc attaaaagga
    22201 ctaataaagt taagtgaaac tattgaaacg gtaaaagaat atacgaacga caagcttgaa
    22261 gtacgaggag tcctatttac taagtataat aagcgttata acatttctaa agaaatgacg
    22321 actgcagcaa ccgaaatttc tagagtcatt ggtgcaaaaa ttttcaaaac ttatattcgt
    22381 agaacaataa ccgttgacga agcgcaagct gctggatcag atctaatcaa ttttaataaa
    22441 ccctcaacag ctgaagatga ctataaagca tttacagaag aatatttaaa agaagttggt
    22501 gattttgatg gcagaagata atcgcagtca agctgcagta agtagactac taggaaataa
    22561 aaataaaaag aactacaaac caaaagaagt agaagaaatc gaattaacca agaaaaatat
    22621 aagtaaagtc ataaaagatc aaggaagtag tgtaagaaca gcagatagca ttcgtataaa
    22681 tccaattcta atgtcagcac tcaaatattg gacgactatt gctgaatcag acaaaagtaa
    22741 accagacgtt atagaagatg cgctattaaa atccatacct gaagaatact tgattgaagg
    22801 atataaacta gcaaagaaac aaaataaaat ttaatttaca ttcaatatca cgatatcata
    22861 atatcgtgat atttttttta taaaaatcag tagtatcaaa gctgataagt cgcttatctt
    22921 catattgtaa tattacgata tcgtgatata atgttattgt aatatcgtga tatagttacc
    22981 atgagcttaa accctgaaat agagcggttt gctttaattt attttttaag gtaaactaaa
    23041 aaaagataaa aaaagactac tgctttaaca aagtttggcg acttatcagc agtagaaaaa
    23101 tatatagtgg atagatatat ttgtttaatt cattgtaaca tagttttgaa caaaacgcta
    23161 tcctacagaa agaggattgg ct
//
