LOCUS       NZ_CP083871            18002 bp    DNA     circular CON 05-NOV-2023
DEFINITION  Escherichia coli strain NDM6 plasmid unnamed4, complete sequence.
ACCESSION   NZ_CP083871
VERSION     NZ_CP083871.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN21398206
            Assembly: GCF_020149705.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Escherichia.
REFERENCE   1  (bases 1 to 18002)
  AUTHORS   Simner,P., Mostafa,H., Bergman,Y., Ante,M., Tekle,T., Adebayo,A.,
            Beisken,S., Dzintars,K. and Tamma,P.D.
  TITLE     Progressive Development of Cefiderocol Resistance in Escherichia
            coli During Therapy Is Associated with Increased blaNDM-5 Copy
            Number and Gene Expression
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 18002)
  AUTHORS   Simner,P., Mostafa,H., Bergman,Y., Ante,M., Tekle,T., Adebayo,A.,
            Beisken,S., Dzintars,K. and Tamma,P.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-SEP-2021) BioIT, Ares-Genetics, Karl-Farkas-Gasse 18,
            Vienna 1180, Austria
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: JAN-2021
            Assembly Method                   :: Canu v. JAN-2021
            Assembly Name                     :: Isolate6
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 234x
            Sequencing Technology :: Oxford Nanopore MiniION + Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 11/05/2023 01:44:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,910
            CDSs (total)                      :: 4,787
            Genes (coding)                    :: 4,426
            CDSs (with protein)               :: 4,426
            Genes (RNA)                       :: 123
            rRNAs                             :: 8, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 88
            ncRNAs                            :: 13
            Pseudo Genes (total)              :: 361
            CDSs (without protein)            :: 361
            Pseudo Genes (ambiguous residues) :: 0 of 361
            Pseudo Genes (frameshifted)       :: 190 of 361
            Pseudo Genes (incomplete)         :: 192 of 361
            Pseudo Genes (internal stop)      :: 56 of 361
            Pseudo Genes (multiple problems)  :: 76 of 361
            Pseudo Genes (short protein)      :: 4 of 361
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP083871.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..18002
                     /organism="Escherichia coli"
                     /mol_type="genomic DNA"
                     /strain="NDM6"
                     /isolation_source="urine"
                     /host="Homo sapiens"
                     /db_xref="taxon:562"
                     /plasmid="unnamed4"
                     /geo_loc_name="USA: Baltimore"
                     /lat_lon="39.296 N 76.591 W"
                     /collection_date="2020"
                     /collected_by="Johns Hopkins University"
                     /genotype="ST167"
     gene            complement(join(<18002..<18002,1..1035))
                     /locus_tag="LCE24_RS24330"
                     /old_locus_tag="LCE24_24330"
                     /pseudo=""
     CDS             complement(join(<18002..<18002,1..1035))
                     /locus_tag="LCE24_RS24330"
                     /old_locus_tag="LCE24_24330"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_313120.1"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="MFS transporter"
                     /name="MFS transporter"
     gene            complement(1325..2203)
                     /locus_tag="LCE24_RS24335"
                     /old_locus_tag="LCE24_24335"
     CDS             complement(1325..2203)
                     /locus_tag="LCE24_RS24335"
                     /old_locus_tag="LCE24_24335"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_418534.4"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YjcZ-like family protein"
                     /protein_id="WP_000169188.1"
                     /translation="MTKTLLDGPGRVLESVYPRFLVDLAQGDDARLPQAHQQQFRERLM
                     QELLSRVQLQTWTNGGMLNAPLSLRLTLVEKLASMLDPGHLALTQIAQHLALLQKMDHR
                     QHSAFPELPQQIAALYEWFSARCRWKEKALTQRGLLVQAGDQSEQIFTRWRAGAYNAWS
                     LPGRCFIVLEELRWGAFGDACRLGSPQAVALLLGDLLEKATQHLAESINAAPTTRHYYH
                     QWFASSTVPTGGEHADFLSWLGKWTTADKQPVCWSVTQRWQTVALGMPRLCSAQRLAGA
                     MLEEIFSVNLA"
                     /name="YjcZ-like family protein"
     gene            complement(2200..4426)
                     /gene="crfC"
                     /locus_tag="LCE24_RS24340"
                     /old_locus_tag="LCE24_24340"
                     /pseudo=""
     CDS             complement(2200..4426)
                     /gene="crfC"
                     /locus_tag="LCE24_RS24340"
                     /old_locus_tag="LCE24_24340"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_418533.1"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="clamp-binding protein CrfC"
                     /name="crfC"
     gene            4827..5162
                     /locus_tag="LCE24_RS24345"
                     /old_locus_tag="LCE24_24345"
     CDS             4827..5162
                     /locus_tag="LCE24_RS24345"
                     /old_locus_tag="LCE24_24345"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_313117.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc ribbon domain-containing protein YjdM"
                     /protein_id="WP_001300891.1"
                     /translation="MSLPHCPKCNSEYTYEDNGMYICPECAYEWNDAEPAQESDELIVK
                     DANGNLLADGDSVTIIKDLKVKGSSSMLKIGTKVKNIRLVEGDHNIDCKIDGFGPMKLK
                     SEFVKKN"
                     /name="zinc ribbon domain-containing protein YjdM"
     gene            5720..6163
                     /gene="yjdN"
                     /locus_tag="LCE24_RS24350"
                     /old_locus_tag="LCE24_24350"
     CDS             5720..6163
                     /gene="yjdN"
                     /locus_tag="LCE24_RS24350"
                     /old_locus_tag="LCE24_24350"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_418531.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family metalloprotein YjdN"
                     /protein_id="WP_001131339.1"
                     /translation="MPLSPYLSFAGNCSDAIAYYQRTLGAELLYKISFGEMPKSAQDSA
                     ENCPSGMQFPDTAIAHANVRIAGSDIMMSDAMPSGKASYSGFTLVLDSQQVEEGKRWFD
                     NLAANGKIEMAWQETFWAHGFGKVTDKFGVPWMINVVKQQPTQ"
                     /name="yjdN"
     gene            6295..7083
                     /gene="phnC"
                     /locus_tag="LCE24_RS24355"
                     /old_locus_tag="LCE24_24355"
     CDS             6295..7083
                     /gene="phnC"
                     /locus_tag="LCE24_RS24355"
                     /old_locus_tag="LCE24_24355"
                     /EC_number="7.3.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_418530.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphonate ABC transporter ATP-binding protein"
                     /protein_id="WP_001193409.1"
                     /translation="MQTIIRVEKLAKTFNQHQALHAVDLNIHHGEMVALLGPSGSGKST
                     LLRHLSGLITGDKSVGSHIELLGRTVQREGRLARDIRKSRAHTGYIFQQFNLVNRLSVL
                     ENVLIGALGSTPFWRTCFSWFTGEQKQRALQALTRVGMVHFAHQRVSTLSGGQQQRVAI
                     ARALMQQAKVILADEPIASLDPESARIVMDTLRDINQNDGITVVVTLHQVDYALRYCER
                     IVALRQGHVFYDGSSQQFDNERFDHLYRSINRVEENAKAA"
                     /name="phnC"
     gene            7108..8124
                     /gene="phnD"
                     /locus_tag="LCE24_RS24360"
                     /old_locus_tag="LCE24_24360"
     CDS             7108..8124
                     /gene="phnD"
                     /locus_tag="LCE24_RS24360"
                     /old_locus_tag="LCE24_24360"
                     /EC_number="7.3.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_418529.1"
                     /GO_component="GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA]"
                     /GO_process="GO:0015716 - organic phosphonate transport
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphonate ABC transporter substrate-binding
                     protein"
                     /protein_id="WP_000992002.1"
                     /translation="MNAKIIASLAFTSMFSLSTLLSPAHAEEQEKALNFGIISTESQQN
                     LKPQWTPFLQDMEKKLGVKVNAFFAPDYAGIIQGMRFNKVDIAWYGNLSAMEAVDRANG
                     QVFAQTVAADGSPGYWSVLIVNKDSPINNLNDLLAKRKDLTFGNGDPNSTSGFLVPGYY
                     VFAKNNISASDFKRTVNAGHETNALAVANKQVDVATNNTENLDKLKTSAPEKLKELKVI
                     WKSPLIPGDPIVWRKNLSETTKDKIYDFFMNYGKTPEEKAVLERLGWAPFRASSDLQLV
                     PIRQLALFKEMQGVKSNKGLNEQDKLAKTTEIQAQLDDLDRLNNALSAMSSVSKAVQ"
                     /name="phnD"
     gene            8230..9017
                     /gene="phnE"
                     /locus_tag="LCE24_RS24365"
                     /old_locus_tag="LCE24_24365"
                     /pseudo=""
     CDS             8230..9017
                     /gene="phnE"
                     /locus_tag="LCE24_RS24365"
                     /old_locus_tag="LCE24_24365"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_313113.2"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]; GO:0005886 - plasma membrane [Evidence
                     IEA]"
                     /GO_function="GO:0015416 - ABC-type phosphonate transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0015716 - organic phosphonate transport
                     [Evidence IEA]"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="phosphonate ABC transporter, permease protein
                     PhnE"
                     /name="phnE"
     gene            9038..9762
                     /gene="phnF"
                     /locus_tag="LCE24_RS24370"
                     /old_locus_tag="LCE24_24370"
                     /pseudo=""
     CDS             9038..9762
                     /gene="phnF"
                     /locus_tag="LCE24_RS24370"
                     /old_locus_tag="LCE24_24370"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_418526.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="phosphonate metabolism transcriptional regulator
                     PhnF"
                     /name="phnF"
     gene            9763..10215
                     /gene="phnG"
                     /locus_tag="LCE24_RS24375"
                     /old_locus_tag="LCE24_24375"
     CDS             9763..10215
                     /gene="phnG"
                     /locus_tag="LCE24_RS24375"
                     /old_locus_tag="LCE24_24375"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_418525.1"
                     /GO_process="GO:0019634 - organic phosphonate metabolic
                     process [Evidence IEA]; GO:0015716 - organic phosphonate
                     transport [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphonate C-P lyase system protein PhnG"
                     /protein_id="WP_000542790.1"
                     /translation="MHADTATRQHWMSVLAHSQPAELAARLNALNITADYEVIRAAETG
                     LVQIQARMGGTGERFFAGDATLTRAAVRLTDGTLGYSWVQGRDKQHAERCALIDALMQQ
                     SRHFQNLSETLIAPLDADRMARIAARQAEVNASRVDFFTMVRGDNA"
                     /name="phnG"
     gene            10212..10796
                     /gene="phnH"
                     /locus_tag="LCE24_RS24380"
                     /old_locus_tag="LCE24_24380"
     CDS             10212..10796
                     /gene="phnH"
                     /locus_tag="LCE24_RS24380"
                     /old_locus_tag="LCE24_24380"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_418524.1"
                     /GO_process="GO:0019634 - organic phosphonate metabolic
                     process [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphonate C-P lyase system protein PhnH"
                     /protein_id="WP_000171628.1"
                     /translation="MTLETAFMLPVQDAQHSFRRLLKAMSEPGVIVALHQLKRGWQPLN
                     IATTSVLLTLADNDTPVWLSTPLNNDIVNQSLRFHTNAPLVSQPEQATFAVTDEAISSE
                     QLNALSTGTAVAPEAGATLILQVASLSGGRMLRLTGAGIAEERMIAPQLPECILHELTE
                     RPHPFPLGIDLILTCGERLLAIPRTTHVEVC"
                     /name="phnH"
     gene            10796..11860
                     /gene="phnI"
                     /locus_tag="LCE24_RS24385"
                     /old_locus_tag="LCE24_24385"
     CDS             10796..11860
                     /gene="phnI"
                     /locus_tag="LCE24_RS24385"
                     /old_locus_tag="LCE24_24385"
                     /EC_number="2.7.8.37"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_418523.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-D-ribose 1-methylphosphonate 5-triphosphate
                     synthase subunit PhnI"
                     /protein_id="WP_001295388.1"
                     /translation="MYVAVKGGEKAIDAAHALQESRRRGDTDLPELSVAQIEQQLNLAV
                     DRVMTEGGIADRELAALALKQASGDNVEAIFLLRAYRTTLAKLAVSEPLDTTGMRLERR
                     ISAVYKDIPGGQLLGPTYDYTHRLLDFTLLANGEAPTLTTADSEQQPSPHVFSLLARQG
                     LAKFEEDSGAQPDDITRTPPVYPCSRSSRLQQLMRGDEGYLLALAYSTQRGYGRNHPFA
                     GEIRSGYIDVSIVPEELGFAVNVGELLMTECEMVNGFIDPPGEPPHFTRGYGLVFGMSE
                     RKAMAMALVDRALQAPEYGEHATGPAQDEEFVLAHADNVEAAGFVSHLKLPHYVDFQAE
                     LELLKRLQQEQNHG"
                     /name="phnI"
     gene            11853..12698
                     /gene="phnJ"
                     /locus_tag="LCE24_RS24390"
                     /old_locus_tag="LCE24_24390"
     CDS             11853..12698
                     /gene="phnJ"
                     /locus_tag="LCE24_RS24390"
                     /old_locus_tag="LCE24_24390"
                     /EC_number="4.7.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_418522.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-D-ribose 1-methylphosphonate 5-phosphate
                     C-P-lyase PhnJ"
                     /protein_id="WP_000002303.1"
                     /translation="MANLSGYNFAYLDEQTKRMIRRAILKAVAIPGYQVPFGGREMPMP
                     YGWGTGGIQLTASVIGESDVLKVIDQGADDTTNAVSIRNFFKRVTGVNTTERTDDATVI
                     QTRHRIPETPLTEDQIIIFQVPIPEPLRFIEPRETETRTMHALEEYGVMQVKLYEDIAR
                     FGHIATTYAYPVKVNGRYVMDPSPIPKFDNPKMDMMPALQLFGAGREKRIYAVPPFTRV
                     ESLDFDDHPFTVQQWDEPCAICGSTHSYLDEVVLDDAGNRMFVCSDTDYCRQQSEAKNQ
                     "
                     /name="phnJ"
     gene            12695..13453
                     /gene="phnK"
                     /locus_tag="LCE24_RS24395"
                     /old_locus_tag="LCE24_24395"
     CDS             12695..13453
                     /gene="phnK"
                     /locus_tag="LCE24_RS24395"
                     /old_locus_tag="LCE24_24395"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_026282.1"
                     /GO_function="GO:0018835 - carbon phosphorus lyase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019634 - organic phosphonate metabolic
                     process [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphonate C-P lyase system protein PhnK"
                     /protein_id="WP_001075514.1"
                     /translation="MNQPLLSVNNLTHLYAPGKGFSDVSFDLWPGEVLGIVGESGSGKT
                     TLLKSISARLTPQQGEIHYENRSLYAMSEADRRRLLRTEWGVVHQHPLDGLRRQVSAGG
                     NIGERLMATGARHYGDIRATAQKWLEEVEIPANRIDDLPTTFSGGMQQRLQIARNLVTH
                     PKLVFMDEPTGGLDVSVQARLLDLLRGLVVELNLAVVIVTHDLGVARLLADRLLVMKQG
                     QVVESGLTDRVLDDPHHPYTQLLVSSVLQN"
                     /name="phnK"
     gene            13564..14244
                     /gene="phnL"
                     /locus_tag="LCE24_RS24400"
                     /old_locus_tag="LCE24_24400"
     CDS             13564..14244
                     /gene="phnL"
                     /locus_tag="LCE24_RS24400"
                     /old_locus_tag="LCE24_24400"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_418520.1"
                     /GO_function="GO:0018835 - carbon phosphorus lyase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019634 - organic phosphonate metabolic
                     process [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphonate C-P lyase system protein PhnL"
                     /protein_id="WP_000611405.1"
                     /translation="MINVQNVSKTFILHQQNGVRLPVLNRASLTVNAGECVVLHGHSGS
                     GKSTLLRSLYANYLPDEGQIQIKHGDEWVDLVTAPARKVVEIRKTTVGWVSQFLRVIPR
                     ISALEVVMQPLLDTGVPREACAAKAARLLTRLNVPERLWHLAPSTFSGGEQQRVNIARG
                     FIVDYPILLLDEPTASLDAKNSAAVVELIREAKTRGAAIVGIFHDEAVRNDVADRLHPM
                     GASS"
                     /name="phnL"
     gene            14241..15377
                     /gene="phnM"
                     /locus_tag="LCE24_RS24405"
                     /old_locus_tag="LCE24_24405"
     CDS             14241..15377
                     /gene="phnM"
                     /locus_tag="LCE24_RS24405"
                     /old_locus_tag="LCE24_24405"
                     /EC_number="3.6.1.63"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_418519.1"
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /GO_process="GO:0019700 - organic phosphonate catabolic
                     process [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-D-ribose 1-methylphosphonate 5-triphosphate
                     diphosphatase"
                     /protein_id="WP_000586325.1"
                     /translation="MIINNVKLVLENEVVSGSLEVQNGEIRAFAESQSRLPEAMDGEGG
                     WLLPGLIELHTDNLDKFFTPRPKVDWPAHSAMSSHDALMVASGITTVLDAVAIGDVRDG
                     GDRLENLEKMINAIEETQKRGVNRAEHRLHLRCELPHHTTLPLFEKLVQREPVTLVSLM
                     DHSPGQRQFANREKYREYYQGKYSLTDAQMQQYEEEQLALAARWSQPNRESIAALCRAR
                     KIALASHDDATHAHVAESHQLGSVIAEFPTTFEAAEASRKHGMNVLMGAPNIVRGGSHS
                     GNVAASELAQLGLLDILSSDYYPASLLDAAFRVADDQSNRFTLPQAVKLVTKNPAQALN
                     LQDRGVIGEGKRADLVLAHRKDNHIHIDHVWRQGKRVF"
                     /name="phnM"
     gene            15377..15934
                     /gene="phnN"
                     /locus_tag="LCE24_RS24410"
                     /old_locus_tag="LCE24_24410"
     CDS             15377..15934
                     /gene="phnN"
                     /locus_tag="LCE24_RS24410"
                     /old_locus_tag="LCE24_24410"
                     /EC_number="2.7.4.23"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_418518.1"
                     /GO_function="GO:0033863 - ribose 1,5-bisphosphate
                     phosphokinase activity [Evidence IEA]"
                     /GO_process="GO:0006015 - 5-phosphoribose 1-diphosphate
                     biosynthetic process [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ribose 1,5-bisphosphokinase"
                     /protein_id="WP_000971886.1"
                     /translation="MMGKLIWLMGPSGSGKDSLLAELRLREQTQLLVAHRYITRDASAG
                     SENHIALSEQEFFTRAGQNLLALSWHANGLYYGVGVEIDLWLHAGFDVLVNGSRAHLPQ
                     ARARYQSALLPVCLQVSPEILRQRLENRGRENASEINARLARAARYTPQDCHTLNNDGS
                     LRQSVDTLLTLIHQKEKHHACL"
                     /name="phnN"
     gene            15921..16355
                     /gene="phnO"
                     /locus_tag="LCE24_RS24415"
                     /old_locus_tag="LCE24_24415"
     CDS             15921..16355
                     /gene="phnO"
                     /locus_tag="LCE24_RS24415"
                     /old_locus_tag="LCE24_24415"
                     /EC_number="2.3.1.-"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_418517.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="aminoalkylphosphonate N-acetyltransferase"
                     /protein_id="WP_001110490.1"
                     /translation="MPACELRPATQYDTDAVYALICELKQAEFDHHAFRVGFNANLRDP
                     NMRYHLALLDGEVVGMIGLHLQFHLHHVNWIGEIQELVVMPQARGLNVGSKLLAWAEEE
                     ARQAGAEMTELSTNVKRHDAHRFYLREGYEQSHFRFTKAL"
                     /name="phnO"
     gene            16357..17114
                     /gene="phnP"
                     /locus_tag="LCE24_RS24420"
                     /old_locus_tag="LCE24_24420"
                     /pseudo=""
     CDS             16357..17114
                     /gene="phnP"
                     /locus_tag="LCE24_RS24420"
                     /old_locus_tag="LCE24_24420"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_418516.1"
                     /GO_function="GO:0008081 - phosphoric diester hydrolase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019700 - organic phosphonate catabolic
                     process [Evidence IEA]"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="phosphonate metabolism protein PhnP"
                     /name="phnP"
     gene            complement(17261..17590)
                     /gene="yjdP"
                     /locus_tag="LCE24_RS24425"
                     /old_locus_tag="LCE24_24425"
     CDS             complement(17261..17590)
                     /gene="yjdP"
                     /locus_tag="LCE24_RS24425"
                     /old_locus_tag="LCE24_24425"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_026281.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DDRRRQL repeat protein YjdP"
                     /protein_id="WP_000819746.1"
                     /translation="MKRFPLFLLFTLLTLSTVPAQADIIDDTIGNIQQAINDAYNPDRG
                     RDYEDSRDDGWQREVSDDRRRQYDDRRRQFEDRRRQLDDRQRQLDQERRQLEDEERRME
                     DEYGR"
                     /name="yjdP"
     gene            complement(17659..>17790)
                     /gene="rpiB"
                     /locus_tag="LCE24_RS24475"
                     /gene_synonym="alsI"
                     /pseudo=""
     CDS             complement(17659..>17790)
                     /gene="rpiB"
                     /locus_tag="LCE24_RS24475"
                     /gene_synonym="alsI"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001183281.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="bifunctional allose-6-phosphate
                     isomerase/ribose-5-phosphate isomerase RpiB"
                     /name="rpiB"
ORIGIN
        1 gtcgcacctt tcaacggacg atttgccgtc tctttcatgg ttacgccggt gattaaacca
       61 accaccgcca ctaccatcag gtaataggca ggcatcatca gattctgcga gctttcgacc
      121 agccaggccg ccagcgttgg cgtcagaccg gcaaccagca ccgaaatatt aaatgccgcc
      181 gccagcgcgc tgtaacggat atgcgtcggg aacatcgctg gcaaggtaga agccataacg
      241 cccgtaaagc agttaaggat caccgccagc atcagtaacc cggcaaaaat caggccgatg
      301 acgttactgt taatcagaat aaacgccggg atcgccaaca caaacagggc aacactacca
      361 agtagcacaa acggacgacg gccaaaacgg tcactcagca agcccatcac cggctggaca
      421 aacagcatac cgatcataat ggcgataata atcagcaccc cgtggtcttc ggagtaatgc
      481 aggttatgcg acaaataact atggtcgaaa ttaacaccac cacgcccgca cccagcacaa
      541 acccggcaat agaaccgaag tccagccagc tgcccataaa gccacgttta cggtcagggg
      601 agtattccgc aacaaatatc gacgccccgg tatattcacc gccgaccgag aaaccttgtg
      661 ccatcttaca gatcaacagc agaatcggtg cccaaatacc aatcgtgtcg taggacggta
      721 ttaagccaat acgaaacgta ctgatcgaca taatcacaat agtgatagcg aggatcttct
      781 ggcgaccata tttatcgccc aacataccaa agaagagtcc gccaagcggt cgaatcagaa
      841 agggaacgga gaaagtggca agtgcagcaa ccatctgcac gctggggtca ccgggaaaaa
      901 aactttacct aatgcgtaag caacaaaacc ataaacacca aaatcgaacc attccattgc
      961 attacccagt gatgctgcgg taatggcttt acgcagttta ccgtcatcaa taatggtgac
     1021 atcacgaagg gtaatcggtt ttactttttt cctttttcag catagctttc ctcgcagagt
     1081 tggcccattt ccgcaaacgc cagaaaaatc agcgcgacgg ccgcaaaagg ggagcgggaa
     1141 ttgcaggatg caatctctgt aacaagcgta gcgggtttgc ttacaccctc cggttaagga
     1201 atgtacaatc aaaccagttg acgcctgaat tgggcagtta atgacctttt taccctacca
     1261 gtgtttaaat ttgtgatcaa cttcacatgg atttcgttta ggactcattg atgtaactga
     1321 ttatttacgc caaatttaca gagaagattt cctcgagcat tgcccccgcc agacgctgcg
     1381 ctgaacagag tcgtggcatc cccagcgcga cagtttgcca gcgttgggtc actgaccagc
     1441 aaacgggttg tttatctgcc gtggtccact ttcccagcca acttaaaaaa tcagcatgct
     1501 ccccgcccgt cggaacggtc gaagaggcaa accactgatg gtaatagtga cgcgtggtcg
     1561 gtgccgcatt gatactctct gccagatgtt gtgtcgcttt ctcgagcaaa tcacccagca
     1621 acaacgccac cgcttgcggg cttcccagac ggcaggcatc gccaaatgcc ccccagcgca
     1681 actcctccag aacgataaaa cagcgcccag gcaacgacca ggcgttatac gccccagcac
     1741 gccagcgggt aaaaatttgc tcgctctgat cacctgcctg caccagtagg cctcgttgcg
     1801 ttaacgcctt ttccttccag cgacaacggg ctgaaaacca ctcatacaag gcggcaattt
     1861 gctgggggag ctccgggaaa gcagagtgct ggcggtgatc cattttttgc agcagcgcca
     1921 gatgctgcgc gatctgcgtc agtgccagat gaccgggatc cagcatcgac gccagttttt
     1981 ccaccaatgt cagacgcagg ctaagcggcg catttaacat gccgccgttc gtccatgtct
     2041 gaagctgcac acgcgaaaga agttcctgca tcagtcgttc acgaaactgc tgctgatggg
     2101 cttgtggaag gcgggcatca tcaccctgcg ccagatccac taaaaagcgg ggataaaccg
     2161 actccagcac gcgaccgggg ccgtcaagta acgtcttggt caatatcgtt ctgccgtgaa
     2221 aagtgtttga atatcatcgc gtaacagctg ggcgtcggtg taaatccagc cgtgagtcat
     2281 cacagtctgc tgcaattgct gctgcatcag cctgaccacc gattcatttt gttgacgcag
     2341 agccagactt tcgcgtaaac gcgtctgtaa ttccgtcaaa catgaagcga actcagcgaa
     2401 aaaagtattc atgcctgccg taacagattc atcgacctgc tctgccagaa ctttagccat
     2461 ttgttggcaa tagagatcga cttctgcgct taatgctcgt tgcaacacac tgtaatcaac
     2521 cgtttctgtc ggtgatttct catttccccg tccccagtcg ggctgattca accagcgcga
     2581 aaaagtctca cgcacaacgc ctaaacgcgt gctctgctcg tccgttgctt cctggcgcga
     2641 aatgacttca ctgaacagct ggcgagtgtt gaagtgggga actacgccgt gaaaaacagg
     2701 aaaatgaaac ccaggacgaa accctgactc gctcaattcc attttgactt gttgctcaat
     2761 ggggcgaata acatcggtta acacccggca aagggtggat tcaagctcgg caaaacgcag
     2821 cgtaaagtcg cgactgatgg tgttctgcgc cgtctgtcac agtgtctcac agcgggtacg
     2881 aatctcgctt aacggctccg aatcatcctg aaacaaggcg gctaactgca ccttcagcgc
     2941 atcttgctgt tgacgcagaa agtggttggc ggaggtcagg gccagctcga tttcatgttt
     3001 aatctcgccg ctcacctgcg cctgattgag ttgcaatagc tgcaaacttt cttcgatctg
     3061 gtggatattt tgccgcaatt gttcacaagc gacgtttaac ccgtgcgcac gaaaatccag
     3121 gtattcccgc gcctgctgcg cgtaattcaa cagtttatgc gcggcagatc gcagagcata
     3181 caacgaggcg ttagcgtaag cggcatgaag caacgcctga attggctggg cgaaccagcg
     3241 aatcttccca caactgatcg gcagcatgac gaatatgttc gaggtccgcc agatcggcat
     3301 gacgccagcg cctgccaagc gcggcatggg caaaatcttc cacccagcgt tgttgctctg
     3361 gcggtggtaa cttaccgttg ttggctaact catagcgcgc ccgattcgcc aggtagcccc
     3421 acatcgacga caccggaaat atctgctgtg gcgtaataca gcctttcatc agcgtcccgg
     3481 aaatcagtgc ccgcacctgg tcggcgtcgt cactgttacg atcctgttga tcgaacttat
     3541 tgaccagcac gtacagcggc accgattgcc ccaccgccaa aatcgcctca cggacctctt
     3601 catcggagat cgatttcagt tgcgtataat ccagcaccgc cagtaccgcc gaggcgcgtg
     3661 ccagctgctg gttaagcatt ttttgcagat gcggttgccc ggcttcattt ggcccggggt
     3721 atccagtaac gtcaactgac cgggataact ctccagcccc gctagatgga caaactccac
     3781 ttcaatcacg ggaatatgct caatggcggc gtaagcagaa aaaggaaaat cgacgtccag
     3841 cgccttcgcc agtcgcacta aatcattcaa acttttcaga caatgaaaaa taggctgggc
     3901 acccagataa tatttttcga aagcgacgcc attttcgatc cgctgcataa gcgcacgcat
     3961 atctttatct atttccagca catcggtcag atgcttaata tcgcaatcac gcaggcgctg
     4021 ttgtaattgt tgaattaaac aatcgattgg cgcgacatgt gaaaaatgca gtaccggttc
     4081 cttttgcccg ggcgtatggc gaataagcgt cggcagcgca gtcattgggc gattacgatt
     4141 aggcagaacc tccgtaccaa caatggcatt aatggtggtt gatttccctg ctttcatggt
     4201 accgacaatt gcaagcacca tttccagtcg ggaaatttta cgcaactcat tattcagcat
     4261 cgcgtgacgt tcggcgatat taggctgact ccagggtaaa gccagttgtg gcgcgtcgtc
     4321 tccgggtaca gagaggcatt ttttccagta actgcaactg ttggcgagaa agctgtaaca
     4381 ggcgttcagc ctcctgactt aactcataca gggtctgtgt gtacatagaa aattcttcct
     4441 taaagcaaat tatgttattt tatttagcca gattgttttt gagttctgtt ttcggctttt
     4501 ataattactg caagaaataa ttttatattt agtgtgttgt tttttatcag aataaataac
     4561 gtcttctgat acgtttaaaa cgtcagaaag ataaaaatat catgtgaatt aaaaaaagaa
     4621 caagtagagc attaacatta tcttaaataa taaatagagg caaaaagatt attttctttt
     4681 tgcgtttcct ttcaaatgaa aacgatcgtc gtctaaaatc agcagtaccc ccgacaaact
     4741 cagggatttt gtgtataatt gcggcctttt tcggcaatct gccgtttttt ggcgcttttg
     4801 ccctgctgac ttttgaggaa atccacatgt cattaccaca ctgcccaaaa tgcaactccg
     4861 aatacaccta cgaagataac ggcatgtaca tctgcccgga atgtgcctac gaatggaacg
     4921 acgcagaacc tgcacaggaa agcgacgagc tgatcgttaa agatgctaac ggcaatctgc
     4981 tggctgacgg cgacagcgtt accatcatta aagatctgaa ggtgaaaggt agctcttcga
     5041 tgctgaaaat tggcaccaaa gtgaaaaaca tccgcctggt tgaaggcgac cataacatcg
     5101 attgcaaaat cgacggtttt ggtccgatga aactgaaatc tgagtttgtg aaaaagaact
     5161 gattgtattg tgatcggtaa gccggataag gcgctcgcgc cgcatccggc aacggtgccg
     5221 actgcctgat gcgacgcttg cgcgtcttat caggcctaca aattcccgca ccctccgtag
     5281 gccggataag gcgtttacgc cgcatccggc aacagtgcca actgcctgat gcgacgcttg
     5341 cgcgtcttat caggcctaca aattcccgca ccatccgtag gccggataag gcgtttacgc
     5401 cgcatccggc aacggtgccg actgcctgat gcgacgcttg cgcgtcttat caggcctaca
     5461 aattcccgca ccctccgtag gccggataag gcgtttacgc cgcatccggc aatggtgccg
     5521 actgcctgat gcgacgcttg cgcgtcttat caggcctaca aattcccgca ccctccgtag
     5581 gccggataag gcgtttacgc cgcatccggc aacagtgccg actgcctgat gcgacgctcg
     5641 cgcgtcttat caggccgcct ctcatctgta taaatttcga actacactta actggcttct
     5701 cttaactgag gtcaccatca tgccgttaag tccctacctc tcttttgccg gtaactgttc
     5761 cgacgcgatt gcctattatc aacgtacgtt gggcgcggaa ctgctctata aaatcagctt
     5821 cggcgaaatg ccaaaatcag cgcaggacag cgccgagaac tgcccttccg gaatgcaatt
     5881 tcccgatacc gccatcgccc acgccaatgt gcgcattgcc ggaagcgaca tcatgatgag
     5941 cgatgccatg ccgtcaggaa aagccagcta ctccggcttt acgctggtgc tcgattcgca
     6001 acaggtcgaa gaaggaaaac gctggtttga caatcttgcc gctaacggaa aaatcgaaat
     6061 ggcctggcag gaaactttct gggcgcatgg ctttggcaaa gtcaccgata aatttggcgt
     6121 accgtggatg attaatgtcg tcaaacaaca accaacgcaa taacccgccg ggaggccgcc
     6181 ctcccgcact gtcatcgaat tcccgttaac tcttcatctg ttagtcactt ttaattaacc
     6241 aaatcgtcac aataatccgc cacgatggag ccactttttt agggaggctg catcatgcaa
     6301 acgattatcc gtgtcgagaa gctcgccaaa accttcaatc agcatcaggc gctgcatgcg
     6361 gttgatctga acattcatca cggtgaaatg gtggctctgc ttgggccgtc gggttccgga
     6421 aaatccaccc ttttacgtca cttaagcggt ttgattaccg gcgataaatc tgtcggtagc
     6481 catatcgagc tgctgggccg cacagtccag cgcgaaggcc gcctggcccg cgatatccgc
     6541 aaaagccgcg cccataccgg ctacatattc caacaattca acctggtgaa ccgcctgagc
     6601 gtactggaga acgtgctgat tggcgcgctc ggcagcacgc cgttctggcg cacctgtttt
     6661 agctggttca ccggcgagca gaaacagcgc gcgttacagg cgctgacccg cgttggcatg
     6721 gtgcattttg cccatcagcg cgtttccacc ctctccggcg gccagcagca acgtgtggcg
     6781 attgcccgtg cgctgatgca gcaggcgaaa gtgattctgg ccgatgaacc catcgcctcg
     6841 ctggacccag aatcagcgcg catcgtgatg gacaccctgc gcgacatcaa ccagaacgac
     6901 ggcatcaccg tggtcgtcac gctgcatcag gtggattacg ccctgcgcta ctgcgaacgc
     6961 atcgtcgccc tgcgccaggg gcacgtcttc tacgacggca gcagccaaca gtttgataac
     7021 gaacgttttg accatctcta ccgcagcatt aaccgcgtcg aagagaacgc gaaagctgcc
     7081 tgacatcccc atcattgagg aaaacgaatg aacgctaaga taattgcctc gctggccttc
     7141 accagcatgt tcagcctcag caccctgtta agcccggcgc acgccgaaga gcaggaaaag
     7201 gcgttgaatt tcggcattat ttcaacggaa tcacagcaaa acctgaaacc gcaatggacg
     7261 ccgttcttgc aggatatgga gaagaagctg ggcgtgaagg tcaacgcctt ctttgccccg
     7321 gactacgcgg gcattatcca ggggatgcgc ttcaataaag tggatatcgc ctggtacggc
     7381 aatctgtcgg cgatggaagc ggtggatcgc gccaatggcc aggtcttcgc ccagacggtc
     7441 gcggcggatg gatcgccggg ttactggagc gtgttgatcg tcaacaaaga cagtccgatc
     7501 aacaacctga acgatctgct ggcgaagcgg aaagatctca cctttggcaa tggcgatcct
     7561 aactccacct ctggcttcct cgtccccggc tactacgtct tcgccaaaaa caatatctcc
     7621 gccagcgact tcaagcgcac cgtcaacgcc gggcatgaaa ccaacgcgct ggccgtcgcc
     7681 aacaagcagg tggatgttgc caccaacaac accgaaaacc tcgacaagct gaaaacctcc
     7741 gcgccagaga agctgaaaga actgaaggtg atctggaagt cgccgctgat cccaggcgat
     7801 ccgatcgtct ggcgcaagaa tctttccgaa accaccaaag acaagatcta cgacttcttt
     7861 atgaactacg gcaaaacgcc ggaagaaaaa gcggtgctgg aacgcctggg ctgggcgcca
     7921 ttccgcgctt ccagcgacct gcaactggtg ccgattcgcc agctcgcgct gtttaaagag
     7981 atgcagggcg tgaaaagcaa taaaggactg aatgagcagg acaagctggc aaaaaccacc
     8041 gagattcagg cgcagctgga tgacctggac cgcctgaaca acgcgctaag cgcgatgagt
     8101 tcggtgagta aagcggtgca gtaaatcgta ggtcggataa gacgccccgg cgtcgcatcc
     8161 gacaatgtgc aggcgttgat gccggatgcg gtgcaagcac cttatccggc ctacagaccg
     8221 gagccaaaca tgcaaaccat caccatcgcc ccacccaagc gcagctggtt ctcgcttctg
     8281 agctgggccg ttgtactcgc cgtgttggtc gtctcgtggc agggcgcgga aatggccccg
     8341 cttacgctga tcaaagacgg cggcaacatg gcgacgttcg ccgccgactt cttcccgccc
     8401 gatttcagcc agtggcagga ttacctcacc gaaatggccg tcacgctgca aatcgccgtc
     8461 tggggcaccg cgctggcggt ggttctctcc atcccctttg gcctgatgag cgccgaaaac
     8521 ctggtgccgt ggtgggttta ccagcccgtt cgccgcctga tggacgcctg ccgcgccatt
     8581 aacgaaatgg tcttcgccat gctgttcgtg gtcgccgtcg gcctcggccc gttcgctggc
     8641 gtgctggcgt gctggcgctg tttatccaca ccaccggcgt gctctccaag ctgctttccg
     8701 aagcggtgga agcgattgaa cccggcccgg tggaaggcat tcgcgccacc ggtgccaaca
     8761 agctcgaaga gatcctctac ggcgtgctgc cacaggtgat gccactgctg atctcctact
     8821 ccctctatcg cttcgaatcc aacgtccgct cggcgaccgt cgtcggcatg gtcggcgcag
     8881 gcgggatcgg cgtcaccctg tgggaagcga ttcgcggttt ccagttccaa caaacctgcg
     8941 ccctgatggt gcttatcatc gtcacggtca gcctgctgga tttcctctct caacggttgc
     9001 gtaagcactt tatctgataa gcgaggcatt gatatctatg cacttgtcta cacatccgac
     9061 cagctaccca acacgctatc aagagatagc cgcaaaactt gagcaggagc ttcgtcaaca
     9121 ctaccgctgc ggcgactatc ttcccgccga gcagcaactg gcagcgcgct ttgaggtgaa
     9181 tcgccacacc ctgcgccgcg ccatcgacca actggtggaa aaaggctggg tacagcgccg
     9241 tcagggcgtc ggcgtgctgg tgctgatgcg cccgttcgat tacccgctca acgcccaggc
     9301 gcgttttagc cagaatctgc tggatcaggg cagccatccc accagcgaaa aactgctttc
     9361 ggtattgcgc cccgcgtccg gccacgtcgc tgacgcactg gggattaccg aggggagaac
     9421 gtcatccacc tgcgcaccct gcgtcgtgtc aacggcgtcg cgctctgttt aatcgaccac
     9481 tacttcgcgg acctcaccct ctggccgacg ctgcaacgct tcgacagcgg ctcgctgcac
     9541 gattttctgc gcgagcaaac cggaattgcg ctgcgccgca gccagacgcg gatcagcgcc
     9601 cgccgcgccc aggccaaaga gtgccagcgt cttgaaatcc cgaatatgtc gccgctgctg
     9661 tgcgtgcgca cccttaacca ccgtgacggt gaaagcagcc cggcggagta ctccgtcagc
     9721 ctgacgcgcg ccgacatgat tgaattcact atggagcact gaatgcacgc agataccgcg
     9781 acccgccagc actggatgtc cgtgctggcg cacagccaac cggctgaact ggcagcacgc
     9841 ctgaacgcgc taaacatcac cgccgactat gaggtgatcc gcgccgctga aactggcctg
     9901 gtacagattc aggcgcgaat gggcggcacc ggcgaacgtt tttttgccgg cgacgccacg
     9961 ctgacccgcg ccgccgtgcg cctgactgac ggcacgctcg gctacagctg ggtgcagggg
    10021 cgtgataaac agcacgccga acgctgcgcg ctgattgacg cgctgatgca gcaatctcgc
    10081 cactttcaaa acttatcaga aacccttatt gccccgctgg acgctgaccg tatggcacgc
    10141 attgccgcac gccaggccga agtgaacgcc agccgggtcg acttctttac gatggttcgc
    10201 ggagacaacg catgaccctg gaaaccgctt ttatgcttcc cgtgcaggat gcccagcaca
    10261 gttttcgtcg cctgttaaag gccatgagcg agccgggcgt gattgtcgcc ctgcatcagc
    10321 tcaaacgcgg ctggcaaccg ctgaatatcg ccaccaccag cgtgctgctg acgctggccg
    10381 ataacgacac gccggtgtgg ctttctaccc cattaaataa cgatatcgtc aaccagagcc
    10441 tgcgttttca taccaacgcg ccgctggtca gccagccgga acaggcgacc ttcgcggtga
    10501 cggatgaggc gatttccagc gaacagctca acgccctttc caccggcacc gccgttgcgc
    10561 cggaagcggg tgcgacgctg attttacagg tcgccagcct gagcggcgga cgcatgttgc
    10621 gccttactgg tgcgggtatt gccgaagaac gaatgatcgc tccgcagctg ccggagtgca
    10681 ttctgcacga actcaccgag cgcccgcatc cgttcccgct cggcatcgac ctgatcctga
    10741 cctgtggcga gcgcctgctg gctattccgc gaaccactca tgtggaggtg tgctgatgta
    10801 cgttgccgtg aaagggggcg agaaggcgat cgacgccgcc cacgccctgc aagagagccg
    10861 acgccgaggc gataccgatt tgcccgaact gagcgtcgcc cagattgaac agcagcttaa
    10921 cctcgcggta gatcgcgtga tgaccgaagg cggcattgcc gaccgcgaac tggcggcgct
    10981 ggcgctgaaa caggccagcg gcgataacgt tgaagcgatt ttcctgctgc gcgcctaccg
    11041 caccacgttg gcgaagctgg cggtaagcga gccgctcgac accaccggga tgcgtctcga
    11101 acgccgtatc tccgccgttt ataaagacat tcccggcggc cagctgcttg gcccaaccta
    11161 cgactacacc catcgcctgc tcgattttac cctgctggca aacggcgaag cgccgacgct
    11221 gaccaccgcc gacagcgaac agcagccgtc gccgcacgtt ttcagcctgc tggcgcgtca
    11281 ggggctggcg aagtttgaag aggatagcgg cgcacagccg gatgacatca cccgcacgcc
    11341 gccggtttac ccctgctcac gctcctcccg tttgcagcag ttgatgcgcg gcgacgaagg
    11401 ctatttgctg gcgctggcct actccaccca acgcggttac gggcgcaatc acccgttcgc
    11461 aggcgagatc cgcagcggct atatcgacgt gtcgattgtg ccggaagagc tgggatttgc
    11521 ggtgaacgtc ggcgaactgc tgatgactga gtgtgaaatg gttaacggtt ttatcgaccc
    11581 gccgggtgag ccgccgcact tcacgcgcgg ctacgggctg gtgttcggca tgagcgagcg
    11641 caaagcgatg gcgatggcgc tggtcgaccg cgctctgcaa gccccggagt acggcgagca
    11701 cgcgacaggc ccggcgcagg atgaagagtt cgtgctggca catgccgaca acgtcgaagc
    11761 cgcaggcttt gtctcacacc tcaaactccc ccactacgtc gatttccagg ccgaactgga
    11821 gctactcaaa cgtctgcaac aggagcagaa ccatggctaa tctgagcggc tacaactttg
    11881 cctacctcga cgagcagacc aaacgcatga tccgccgcgc catcttaaaa gcggtggcga
    11941 tccccggtta tcaggtgccg tttggcgggc gcgagatgcc gatgccgtac ggctggggaa
    12001 ccggcggcat tcagcttacc gccagcgtga ttggcgaaag cgacgtgctg aaggtgattg
    12061 accagggcgc ggatgacacc accaacgccg tgtcgattcg caacttcttc aagcgcgtga
    12121 ccggggtaaa caccacggaa cgtacggacg atgcgacggt tatccagacg cgtcaccgca
    12181 tccccgaaac gccgctgacc gaagatcaga taattatctt ccaggtgcca atccccgagc
    12241 cgctgcgctt tatcgagccg cgcgaaacgg aaacccgcac catgcacgcg ctggaagagt
    12301 acggcgtgat gcaggtgaaa ctgtatgaag atatcgcccg cttcggtcat atcgccacca
    12361 cctacgccta tccggtgaag gtaaatgggc gctacgtgat ggacccgtcg ccgatcccga
    12421 aattcgataa cccaaaaatg gacatgatgc ccgccctgca actgttcggc gcggggcgcg
    12481 agaagcgcat ctatgcggtg ccgccgttta cccgcgtgga aagtctcgat ttcgacgatc
    12541 acccgttcac cgttcagcag tgggatgagc catgcgccat ctgcggatcg acccacagct
    12601 atcttgatga agtggtgctg gatgacgccg gaaaccgcat gtttgtctgc tccgataccg
    12661 attattgccg ccaacagagc gaggcaaaaa accaatgaat caaccgttac tttcggtcaa
    12721 taacctgacc cacctttacg cgccgggcaa aggctttagc gatgtctctt ttgatttatg
    12781 gccgggggaa gtgctgggca ttgtcgggga atccggctcc gggaagacca cgctgctgaa
    12841 gtcgatctcc gcgcgcctga cgccgcagca gggggaaatt cactacgaga accgttcgct
    12901 gtatgcaatg agcgaggccg accgccgtcg cctgctgcgt accgaatggg gcgtggtgca
    12961 tcagcatcca ctcgacggcc tgcgccgcca ggtgtcggca ggcggcaata tcggcgagcg
    13021 gctgatggcg accggggcac gtcattacgg cgatattcgt gccaccgcgc agaagtggct
    13081 ggaagaggtg gagattcccg ccaaccggat cgacgacctg ccgaccacct tttccggcgg
    13141 tatgcagcag cgtttgcaga ttgcccgcaa cctggtgacg catccgaagc tggtgtttat
    13201 ggatgaaccg accggcgggc tggatgtgtc ggtgcaggcc cgcctgctcg acctgctgcg
    13261 cggcctggtg gtggagctga acctcgcggt ggtgattgtc acccatgatt taggcgtcgc
    13321 ccgcctgctg gcggaccgtt tgctggtgat gaagcagggg caagtggtgg agagtgggtt
    13381 aaccgaccgc gtgctcgacg acccgcatca tccgtataca cagctgctgg tgtcatcggt
    13441 tttgcagaat tgagccggtg ccggatgcgg cgtaaacgcc ttatccggcc tacaaatgcg
    13501 ctccccgtag gtcggataag acgcgtcagc gtcgcatccg acacccgaac cacgaggcga
    13561 aaaatgatta acgtacaaaa cgtcagtaaa accttcatcc tgcaccagca aaacggcgtg
    13621 cgcctgcccg tcctcaatcg cgcctcgctc accgtcaacg cgggcgaatg cgtggtgctc
    13681 cacggccatt ccggcagcgg caaatcaact ctgctacgct cgctgtacgc caactatctg
    13741 cccgacgaag gtcaaatcca gatcaaacac ggtgacgagt gggtagacct ggtcaccgcg
    13801 ccagcgcgca aagtggtgga aatccgcaaa accaccgtcg gctgggtgag ccagtttctg
    13861 cgcgtcatcc cgcgtatctc agcactggaa gtggtgatgc agccgctgct cgataccggc
    13921 gttccgcgtg aagcctgcgc cgctaaagcc gcgcgtcttc tcacccgcct gaacgtgccg
    13981 gaacgcctgt ggcacctggc accatcgaca ttttccggtg gcgaacagca gcgcgtcaac
    14041 atcgcccgcg gctttatcgt cgactacccc attctgctgc ttgacgaacc taccgcctcg
    14101 ctggacgcca aaaacagcgc cgcggtggtg gaactgattc gcgaagccaa aacccgtggc
    14161 gcagccatcg taggcatctt ccatgacgaa gctgtacgta atgacgtcgc cgaccgcctg
    14221 cacccaatgg gagcctcttc atgattatca ataacgttaa gctggtgctg gaaaacgagg
    14281 tggtaagcgg ttcgctggag gtgcagaacg gcgaaatccg cgcctttgcc gaaagccaga
    14341 gccgcctgcc ggaggcgatg gacggcgaag gcggctggct gctgccgggg ctgattgagc
    14401 tgcataccga taatctggat aaattcttca ccccgcgccc gaaagttgac tggcctgccc
    14461 actcggcgat gagcagccac gacgcgctga tggtggcgag cggcatcacc accgtactgg
    14521 atgccgtggc aattggcgac gtgcgcgacg gcggcgatcg gctggagaat ctggagaaga
    14581 tgatcaacgc catcgaagag acgcagaaac gcggcgtcaa ccgcgccgag caccgtctgc
    14641 atctgcgctg cgaactgccg catcacacca cgctgccgct gtttgaaaaa ctggtgcagc
    14701 gcgagccggt gacgctggtg tcgctgatgg accactcgcc gggccagcgc cagttcgcca
    14761 accgcgagaa gtatcgcgaa tattatcagg gcaaatactc cctcactgat gcgcagatgc
    14821 agcagtacga agaagagcaa ctggcgctcg ccgcacgctg gtcgcagccg aatcgcgaat
    14881 ccatcgccgc cctgtgccgc gcgcgaaaaa ttgcgcttgc cagccacgat gacgccaccc
    14941 acgcccacgt tgctgaatct caccagcttg gcagcgtgat cgccgaattt cccaccacgt
    15001 tcgaagcggc ggaagcctcg cgcaagcatg gcatgaacgt gctgatgggc gcgccgaata
    15061 ttgtgcgcgg cggctcgcac tccggcaacg tggcggccag tgaactggcg cagcttggcc
    15121 tgctggatat cctctcttcc gactactacc ccgccagcct gctcgatgcg gcatttcgcg
    15181 tcgccgatga ccagagcaac cgctttacgc tgccgcaggc ggtgaagctg gtgactaaaa
    15241 atccagcgca ggcgcttaat ctccaggatc gcggggtgat tggcgagggc aaacgcgccg
    15301 acctggtgct ggcgcatcgc aaggacaatc atattcatat cgaccacgtc tggcgtcagg
    15361 gtaaaagggt gttctgatga tgggaaaact gatttggtta atggggccgt ccggctccgg
    15421 gaaagacagc ctgctggcgg aactccgcct gcgggaacaa actcagttac tggtggcgca
    15481 tcgctacatc acgcgcgatg ccagcgccgg aagtgaaaac catatcgccc tgagcgagca
    15541 ggagtttttt acccgcgcgg ggcaaaatct gttggcctta agctggcacg ctaacggtct
    15601 gtattatggc gtcggcgtcg agattgatct ctggctgcac gccggattcg acgtgctggt
    15661 caacggctca cgcgcccatc tgccgcaggc gcgggcgcgc tatcaatcgg cgctgctgcc
    15721 cgtctgttta caggtttcgc cggagatcct ccgccagcgc ctggaaaacc gtggccgtga
    15781 aaacgccagt gaaattaacg cccgcctggc gcgcgccgcc cgctatactc cacaggattg
    15841 ccatacgctc aacaatgacg gcagcctgcg ccagtcggtc gacacgctgc tgacgctgat
    15901 ccatcagaag gagaaacacc atgcctgctt gtgagcttcg cccggccacg cagtacgaca
    15961 ccgacgcggt ttacgcgctg atttgtgagc taaaacaggc ggagtttgac caccacgcgt
    16021 ttcgcgtggg ttttaacgcc aatctgcgcg acccaaacat gcgctaccat ctggcgctgc
    16081 ttgatggcga agttgtcggc atgatcggcc tgcatttgca gtttcatctg catcatgtca
    16141 actggatcgg cgaaattcag gagttggtgg taatgccgca ggcgcgcggt ctgaacgtcg
    16201 gcagtaagtt actggcgtgg gcagaagaag aagcccgcca ggccggggcc gaaatgaccg
    16261 aactttcgac caacgtgaag cgccacgacg cgcaccgttt ctatctgcgc gaaggctacg
    16321 agcagagcca cttccgcttc accaaggcgc tgtaacatga gcctgaccct cacgctcacc
    16381 ggcaccggcg gcgcacaggg cgttccggca tggggctgcg agtgtgcggc ctgcgccaga
    16441 gcgcggcgct cgccgcagta tcgccgccaa ccgtgcagcg gcgtagtgaa gtttaacgac
    16501 gcaatcaccc tgatcgacgc cgggctgcac gatctcgccg atcgctggtc gcccggatcg
    16561 ttccagcagt ttttgctgac gcattatcat atggatcacg tccagggctg tttccgctgc
    16621 gctggggcgt tggcgatccg atcccggttt acggcccgcc ggatgaacag ggctgcgacg
    16681 atctgtttaa acatccgggc ctgcttgatt tcagccacac ggtggaaccg tttgtggtgt
    16741 ttgatttgca ggggttacag gtcacgcccc tgccgctcaa ccactcaaaa ctgaccttcg
    16801 gttatctgct ggaaacggca cacagccggg tggcatggct gtctgacacc gcaggcttgc
    16861 cggaaaaaac gctgaaattt ttacgcaata atcagccgca ggtaatggtg atggattgca
    16921 gtcacccgcc gcgcgcggat gcaccgcgta atcactgtga tttaaatacc gtgcttgcgc
    16981 tgaatcaggt tatccgctcg ccacgggtga ttctgaccca tatcagccac cagtttgatg
    17041 cgtggctgat ggaaaacgca ctaccgtcag ggtttgaggt ggggtttgat gggatggaga
    17101 ttggggtggc gtgatgagag ggaatgtgcg cgctggcccc ctcaccctaa ccctctcccc
    17161 agaggggcga ggggaccgat tgtgctcgat attgaatatt gcgctcgttt tctccctctc
    17221 cccattgggg tgaggggcga tgcctgctcc atacccaacc tcatcgccca tactcatctt
    17281 ccattctccg ctcttcatcc tccagttgcc gacgctcctg atcaagctgg cgctggcgat
    17341 cgtccagctg cctgcggcga tcttcaaact ggcggcggcg gtcgtcatat tgtctgcgcc
    17401 gatcgtcgct cacttcacgc tgccagccgt cgtcgcgcga atcttcatag tctcgcccac
    17461 ggtcagggtt ataagcgtca ttaatcgcct gctgaatatt gccaatggtg tcgtcgataa
    17521 tatcggcctg ggccggaacg gtggacagcg tgagcagggt gaataaaaga aatagcggaa
    17581 agcgtttcat tagccaacct caaaaagaaa ctctatccac attaatcatt actcatccat
    17641 gcaagtagtg gatgaatctc aatttctccg ctgctctatt gccgtaatcg cctccacgcg
    17701 ttgttgatga cgaccgcctt cgtactgtgc gcccagccac gcatccacaa tcatttttgc
    17761 cagttcgagg ccaaccactc gtgaaccaaa aagccagcac gttggtgtcg ttatgctgcc
    17821 gcgaaagttg cgcggaataa ggttcgctac agacgaccgc gcgaattccg gcaaacttgt
    17881 tcgccgctat cgaaataccg acgccagtac cacaaatcaa aatcccgcca tcaacctctc
    17941 cgccagcaac agccagtgcg acttgactgg cgtaatgtgg ataatcagta cgctctgacg
    18001 ac
//
