LOCUS       NZ_CP083870            18105 bp    DNA     circular CON 05-NOV-2023
DEFINITION  Escherichia coli strain NDM6 plasmid unnamed3, complete sequence.
ACCESSION   NZ_CP083870
VERSION     NZ_CP083870.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN21398206
            Assembly: GCF_020149705.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Escherichia.
REFERENCE   1  (bases 1 to 18105)
  AUTHORS   Simner,P., Mostafa,H., Bergman,Y., Ante,M., Tekle,T., Adebayo,A.,
            Beisken,S., Dzintars,K. and Tamma,P.D.
  TITLE     Progressive Development of Cefiderocol Resistance in Escherichia
            coli During Therapy Is Associated with Increased blaNDM-5 Copy
            Number and Gene Expression
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 18105)
  AUTHORS   Simner,P., Mostafa,H., Bergman,Y., Ante,M., Tekle,T., Adebayo,A.,
            Beisken,S., Dzintars,K. and Tamma,P.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-SEP-2021) BioIT, Ares-Genetics, Karl-Farkas-Gasse 18,
            Vienna 1180, Austria
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: JAN-2021
            Assembly Method                   :: Canu v. JAN-2021
            Assembly Name                     :: Isolate6
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 234x
            Sequencing Technology :: Oxford Nanopore MiniION + Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 11/05/2023 01:44:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,910
            CDSs (total)                      :: 4,787
            Genes (coding)                    :: 4,426
            CDSs (with protein)               :: 4,426
            Genes (RNA)                       :: 123
            rRNAs                             :: 8, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 88
            ncRNAs                            :: 13
            Pseudo Genes (total)              :: 361
            CDSs (without protein)            :: 361
            Pseudo Genes (ambiguous residues) :: 0 of 361
            Pseudo Genes (frameshifted)       :: 190 of 361
            Pseudo Genes (incomplete)         :: 192 of 361
            Pseudo Genes (internal stop)      :: 56 of 361
            Pseudo Genes (multiple problems)  :: 76 of 361
            Pseudo Genes (short protein)      :: 4 of 361
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP083870.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..18105
                     /organism="Escherichia coli"
                     /mol_type="genomic DNA"
                     /strain="NDM6"
                     /isolation_source="urine"
                     /host="Homo sapiens"
                     /db_xref="taxon:562"
                     /plasmid="unnamed3"
                     /geo_loc_name="USA: Baltimore"
                     /lat_lon="39.296 N 76.591 W"
                     /collection_date="2020"
                     /collected_by="Johns Hopkins University"
                     /genotype="ST167"
     gene            join(<18105..<18105,1..538)
                     /locus_tag="LCE24_RS24220"
                     /old_locus_tag="LCE24_24220"
                     /pseudo=""
     CDS             join(<18105..<18105,1..538)
                     /locus_tag="LCE24_RS24220"
                     /old_locus_tag="LCE24_24220"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_418536.1"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /name="ATP-binding protein"
     gene            complement(708..2232)
                     /gene="proP"
                     /locus_tag="LCE24_RS24230"
                     /old_locus_tag="LCE24_24230"
                     /pseudo=""
     CDS             complement(708..2232)
                     /gene="proP"
                     /locus_tag="LCE24_RS24230"
                     /old_locus_tag="LCE24_24230"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_313120.1"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="glycine betaine/L-proline transporter ProP"
                     /name="proP"
     gene            complement(2471..3349)
                     /locus_tag="LCE24_RS24235"
                     /old_locus_tag="LCE24_24235"
     CDS             complement(2471..3349)
                     /locus_tag="LCE24_RS24235"
                     /old_locus_tag="LCE24_24235"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_418534.4"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="YjcZ-like family protein"
                     /protein_id="WP_000169188.1"
                     /translation="MTKTLLDGPGRVLESVYPRFLVDLAQGDDARLPQAHQQQFRERLM
                     QELLSRVQLQTWTNGGMLNAPLSLRLTLVEKLASMLDPGHLALTQIAQHLALLQKMDHR
                     QHSAFPELPQQIAALYEWFSARCRWKEKALTQRGLLVQAGDQSEQIFTRWRAGAYNAWS
                     LPGRCFIVLEELRWGAFGDACRLGSPQAVALLLGDLLEKATQHLAESINAAPTTRHYYH
                     QWFASSTVPTGGEHADFLSWLGKWTTADKQPVCWSVTQRWQTVALGMPRLCSAQRLAGA
                     MLEEIFSVNLA"
                     /name="YjcZ-like family protein"
     gene            complement(3346..5574)
                     /gene="crfC"
                     /locus_tag="LCE24_RS24240"
                     /old_locus_tag="LCE24_24240"
                     /pseudo=""
     CDS             complement(3346..5574)
                     /gene="crfC"
                     /locus_tag="LCE24_RS24240"
                     /old_locus_tag="LCE24_24240"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_418533.1"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="clamp-binding protein CrfC"
                     /name="crfC"
     gene            5975..6310
                     /locus_tag="LCE24_RS24245"
                     /old_locus_tag="LCE24_24245"
     CDS             5975..6310
                     /locus_tag="LCE24_RS24245"
                     /old_locus_tag="LCE24_24245"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_313117.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="zinc ribbon domain-containing protein YjdM"
                     /protein_id="WP_001300891.1"
                     /translation="MSLPHCPKCNSEYTYEDNGMYICPECAYEWNDAEPAQESDELIVK
                     DANGNLLADGDSVTIIKDLKVKGSSSMLKIGTKVKNIRLVEGDHNIDCKIDGFGPMKLK
                     SEFVKKN"
                     /name="zinc ribbon domain-containing protein YjdM"
     gene            6868..7309
                     /gene="yjdN"
                     /locus_tag="LCE24_RS24250"
                     /old_locus_tag="LCE24_24250"
                     /pseudo=""
     CDS             6868..7309
                     /gene="yjdN"
                     /locus_tag="LCE24_RS24250"
                     /old_locus_tag="LCE24_24250"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_418531.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="VOC family metalloprotein YjdN"
                     /name="yjdN"
     gene            7442..8230
                     /gene="phnC"
                     /locus_tag="LCE24_RS24255"
                     /old_locus_tag="LCE24_24255"
     CDS             7442..8230
                     /gene="phnC"
                     /locus_tag="LCE24_RS24255"
                     /old_locus_tag="LCE24_24255"
                     /EC_number="7.3.2.2"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_418530.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphonate ABC transporter ATP-binding protein"
                     /protein_id="WP_001193409.1"
                     /translation="MQTIIRVEKLAKTFNQHQALHAVDLNIHHGEMVALLGPSGSGKST
                     LLRHLSGLITGDKSVGSHIELLGRTVQREGRLARDIRKSRAHTGYIFQQFNLVNRLSVL
                     ENVLIGALGSTPFWRTCFSWFTGEQKQRALQALTRVGMVHFAHQRVSTLSGGQQQRVAI
                     ARALMQQAKVILADEPIASLDPESARIVMDTLRDINQNDGITVVVTLHQVDYALRYCER
                     IVALRQGHVFYDGSSQQFDNERFDHLYRSINRVEENAKAA"
                     /name="phnC"
     gene            8255..9270
                     /gene="phnD"
                     /locus_tag="LCE24_RS24260"
                     /old_locus_tag="LCE24_24260"
                     /pseudo=""
     CDS             8255..9270
                     /gene="phnD"
                     /locus_tag="LCE24_RS24260"
                     /old_locus_tag="LCE24_24260"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_418529.1"
                     /GO_component="GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA]"
                     /GO_process="GO:0015716 - organic phosphonate transport
                     [Evidence IEA]"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="phosphonate ABC transporter substrate-binding
                     protein"
                     /name="phnD"
     gene            9376..10163
                     /gene="phnE"
                     /locus_tag="LCE24_RS24265"
                     /old_locus_tag="LCE24_24265"
                     /pseudo=""
     CDS             9376..10163
                     /gene="phnE"
                     /locus_tag="LCE24_RS24265"
                     /old_locus_tag="LCE24_24265"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_313113.2"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]; GO:0005886 - plasma membrane [Evidence
                     IEA]"
                     /GO_function="GO:0015416 - ABC-type phosphonate transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0015716 - organic phosphonate transport
                     [Evidence IEA]"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="phosphonate ABC transporter, permease protein
                     PhnE"
                     /name="phnE"
     gene            10184..10907
                     /gene="phnF"
                     /locus_tag="LCE24_RS24270"
                     /old_locus_tag="LCE24_24270"
                     /pseudo=""
     CDS             10184..10907
                     /gene="phnF"
                     /locus_tag="LCE24_RS24270"
                     /old_locus_tag="LCE24_24270"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_418526.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="phosphonate metabolism transcriptional regulator
                     PhnF"
                     /name="phnF"
     gene            10908..11360
                     /gene="phnG"
                     /locus_tag="LCE24_RS24275"
                     /old_locus_tag="LCE24_24275"
     CDS             10908..11360
                     /gene="phnG"
                     /locus_tag="LCE24_RS24275"
                     /old_locus_tag="LCE24_24275"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_418525.1"
                     /GO_process="GO:0019634 - organic phosphonate metabolic
                     process [Evidence IEA]; GO:0015716 - organic phosphonate
                     transport [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphonate C-P lyase system protein PhnG"
                     /protein_id="WP_000542790.1"
                     /translation="MHADTATRQHWMSVLAHSQPAELAARLNALNITADYEVIRAAETG
                     LVQIQARMGGTGERFFAGDATLTRAAVRLTDGTLGYSWVQGRDKQHAERCALIDALMQQ
                     SRHFQNLSETLIAPLDADRMARIAARQAEVNASRVDFFTMVRGDNA"
                     /name="phnG"
     gene            11357..11941
                     /gene="phnH"
                     /locus_tag="LCE24_RS24280"
                     /old_locus_tag="LCE24_24280"
     CDS             11357..11941
                     /gene="phnH"
                     /locus_tag="LCE24_RS24280"
                     /old_locus_tag="LCE24_24280"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_418524.1"
                     /GO_process="GO:0019634 - organic phosphonate metabolic
                     process [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphonate C-P lyase system protein PhnH"
                     /protein_id="WP_000171628.1"
                     /translation="MTLETAFMLPVQDAQHSFRRLLKAMSEPGVIVALHQLKRGWQPLN
                     IATTSVLLTLADNDTPVWLSTPLNNDIVNQSLRFHTNAPLVSQPEQATFAVTDEAISSE
                     QLNALSTGTAVAPEAGATLILQVASLSGGRMLRLTGAGIAEERMIAPQLPECILHELTE
                     RPHPFPLGIDLILTCGERLLAIPRTTHVEVC"
                     /name="phnH"
     gene            11941..13004
                     /gene="phnI"
                     /locus_tag="LCE24_RS24285"
                     /old_locus_tag="LCE24_24285"
                     /pseudo=""
     CDS             11941..13004
                     /gene="phnI"
                     /locus_tag="LCE24_RS24285"
                     /old_locus_tag="LCE24_24285"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_418523.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-D-ribose 1-methylphosphonate 5-triphosphate
                     synthase subunit PhnI"
                     /name="phnI"
     gene            12997..13842
                     /gene="phnJ"
                     /locus_tag="LCE24_RS24290"
                     /old_locus_tag="LCE24_24290"
     CDS             12997..13842
                     /gene="phnJ"
                     /locus_tag="LCE24_RS24290"
                     /old_locus_tag="LCE24_24290"
                     /EC_number="4.7.1.1"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_418522.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-D-ribose 1-methylphosphonate 5-phosphate
                     C-P-lyase PhnJ"
                     /protein_id="WP_000002303.1"
                     /translation="MANLSGYNFAYLDEQTKRMIRRAILKAVAIPGYQVPFGGREMPMP
                     YGWGTGGIQLTASVIGESDVLKVIDQGADDTTNAVSIRNFFKRVTGVNTTERTDDATVI
                     QTRHRIPETPLTEDQIIIFQVPIPEPLRFIEPRETETRTMHALEEYGVMQVKLYEDIAR
                     FGHIATTYAYPVKVNGRYVMDPSPIPKFDNPKMDMMPALQLFGAGREKRIYAVPPFTRV
                     ESLDFDDHPFTVQQWDEPCAICGSTHSYLDEVVLDDAGNRMFVCSDTDYCRQQSEAKNQ
                     "
                     /name="phnJ"
     gene            13839..14597
                     /gene="phnK"
                     /locus_tag="LCE24_RS24295"
                     /old_locus_tag="LCE24_24295"
     CDS             13839..14597
                     /gene="phnK"
                     /locus_tag="LCE24_RS24295"
                     /old_locus_tag="LCE24_24295"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_026282.1"
                     /GO_function="GO:0018835 - carbon phosphorus lyase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019634 - organic phosphonate metabolic
                     process [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphonate C-P lyase system protein PhnK"
                     /protein_id="WP_001075514.1"
                     /translation="MNQPLLSVNNLTHLYAPGKGFSDVSFDLWPGEVLGIVGESGSGKT
                     TLLKSISARLTPQQGEIHYENRSLYAMSEADRRRLLRTEWGVVHQHPLDGLRRQVSAGG
                     NIGERLMATGARHYGDIRATAQKWLEEVEIPANRIDDLPTTFSGGMQQRLQIARNLVTH
                     PKLVFMDEPTGGLDVSVQARLLDLLRGLVVELNLAVVIVTHDLGVARLLADRLLVMKQG
                     QVVESGLTDRVLDDPHHPYTQLLVSSVLQN"
                     /name="phnK"
     gene            14709..15396
                     /gene="phnL"
                     /locus_tag="LCE24_RS24300"
                     /old_locus_tag="LCE24_24300"
                     /pseudo=""
     CDS             14709..15396
                     /gene="phnL"
                     /locus_tag="LCE24_RS24300"
                     /old_locus_tag="LCE24_24300"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008455726.1"
                     /GO_function="GO:0018835 - carbon phosphorus lyase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019634 - organic phosphonate metabolic
                     process [Evidence IEA]"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="phosphonate C-P lyase system protein PhnL"
                     /name="phnL"
     gene            15383..>16503
                     /gene="phnM"
                     /locus_tag="LCE24_RS24305"
                     /old_locus_tag="LCE24_24305"
                     /pseudo=""
     CDS             15383..>16503
                     /gene="phnM"
                     /locus_tag="LCE24_RS24305"
                     /old_locus_tag="LCE24_24305"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_418519.1"
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /GO_process="GO:0019700 - organic phosphonate catabolic
                     process [Evidence IEA]"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="alpha-D-ribose 1-methylphosphonate 5-triphosphate
                     diphosphatase"
                     /name="phnM"
     gene            16516..17072
                     /gene="phnN"
                     /locus_tag="LCE24_RS24310"
                     /old_locus_tag="LCE24_24310"
                     /pseudo=""
     CDS             16516..17072
                     /gene="phnN"
                     /locus_tag="LCE24_RS24310"
                     /old_locus_tag="LCE24_24310"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_418518.1"
                     /GO_function="GO:0033863 - ribose 1,5-bisphosphate
                     phosphokinase activity [Evidence IEA]"
                     /GO_process="GO:0006015 - 5-phosphoribose 1-diphosphate
                     biosynthetic process [Evidence IEA]"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="ribose 1,5-bisphosphokinase"
                     /name="phnN"
     gene            17059..17491
                     /gene="phnO"
                     /locus_tag="LCE24_RS24315"
                     /old_locus_tag="LCE24_24315"
                     /pseudo=""
     CDS             17059..17491
                     /gene="phnO"
                     /locus_tag="LCE24_RS24315"
                     /old_locus_tag="LCE24_24315"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_418517.1"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="aminoalkylphosphonate N-acetyltransferase"
                     /name="phnO"
     gene            17493..>18041
                     /gene="phnP"
                     /locus_tag="LCE24_RS24320"
                     /old_locus_tag="LCE24_24320"
                     /pseudo=""
     CDS             17493..>18041
                     /gene="phnP"
                     /locus_tag="LCE24_RS24320"
                     /old_locus_tag="LCE24_24320"
                     /inference="COORDINATES: protein motif:HMM:TIGR03307.1"
                     /GO_function="GO:0008081 - phosphoric diester hydrolase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019700 - organic phosphonate catabolic
                     process [Evidence IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="phosphonate metabolism protein PhnP"
                     /name="phnP"
ORIGIN
        1 agatgatgga gagcgtctcc cagctgctgc aactggcgcg tgccggacag tcattttctt
       61 ccggtaatta tcaacatgta aaactgctga agatgtcatt ctcccctcgt atgacgaact
      121 cagtaccatg ctcgaccagc gacagcaaac cctgctattg ccagagagcg ccgccgacat
      181 caccgttcag ggtgatgcaa ccctgctgcg gatgttattg cgaaacctgg tagaaaacgc
      241 ccatcgttac agcccgcaag gcagcaacat tatgattaag ctgcaagaag atgacggagc
      301 ggtcatggca gttgaagatg aaggaccagg tattgatgag agtaaatgcg gggagttgag
      361 taaagcgttt gtacgtatgg acagccgtta tggcgggatt ggtctggggt taagtattgt
      421 cagccgcatt acacagttgc atcacgggca gtttttcctg caaaaccggc aagagacttc
      481 cggcacgcgg gcctgggtac ggctgaagaa agatcagtac gtggcaaacc agatataaag
      541 aaagctgctg accaccagca cgctgaaaca cggtagttaa actttcataa cacggttttc
      601 attgcactct cctccgcaac ctggagggag agtatgcgcg atcagagatt aagtgaacct
      661 taagagttca attggctgat agagacagcg tcgggccatc cgtttcctta ttcatcaatt
      721 cgcggatgtt gctgcaccag gcgggtacgt ttcgcctgca aatcggcaat cctcgtggtc
      781 aatatcatcg attttctgct cgatattatc gtaatgctcg acgagaattt ccttcgcttc
      841 ctgtatatct gacgccgccg gtgtcgcacc tttcaacgga cgatttgccg tctctttcat
      901 ggttacgccg gtgattaaac caaccaccgc cactaccatc aggtaatagg caggcatcat
      961 cagattctgc gagctttcga ccagccaggc cgccagcgtt ggcgtcagac cggcaaccag
     1021 caccgaaata ttaaatgccg ccgccagcgc gctgtaacgg atatgcgtcg ggaacatcgc
     1081 tggcaaggta gaagccataa cgcccgtaaa gcagttaagg atcaccgcca gcatcagtaa
     1141 cccggcaaaa atcaggccga tgacgttact gttaatcaga ataaacgccg ggatcgccaa
     1201 cacaaacagg gcaacactac caagtagcac aaacggacga cggccaaaac ggtcactcag
     1261 caagcccatc accggctgga caaacagcat accgatcata atggcgataa taatcagcac
     1321 cccgtggtct tcggagtaat gcaggttatg cgacaaataa ctcggcatat aggtcagcaa
     1381 catgtagtaa gtcacgttgg tggcaattac cagaccaata catgtcaaca ggctgcgcca
     1441 gtatttagtg gcaatctctt taaacgagac tttcgggcca tcctgcaaac cttcacggtc
     1501 gccctgttcc agtttatcga catgctgctg gaacgccgga gtctcttcca gcgcatggcg
     1561 caggtaaagc ccgataatcc ctaacggcag agcgataaag aacggaatac gccagcccca
     1621 atcgaggaag ttcgcttcgc cgacaatggt cgaaattaac accaccacgc ccgcacccag
     1681 cacaaacccg gcaatagaac cgaagtccag ccagctgccc ataaagccac gtttacggtc
     1741 agggagtatt ccgcaacaaa tatcgacgcc ccggtatatt caccgccgac cgagaaacct
     1801 tgtgccatct tacagatcaa cagcagaatc ggtgcccaaa taccaatcgt gtcgtaggac
     1861 ggtattaagc caatacagaa cgtactgatc gacataatca caatagtgat agcgaggatc
     1921 ttctggcgac catatttatc gcccaacata ccaaagaaga gtccgccaag cggtcgaatc
     1981 agaaagggaa cggagaaagt ggcaagtgca gcaaccatct gcacgctggg gtcagccccg
     2041 ggaaaaaact ttacctaatg cgtaagcaac aaaaccataa acaccaaaat cgaaccattc
     2101 cattgcatta cccagtgatg ctgcggtaat ggctttacgc agtttaccgt catcaataat
     2161 ggtgacatca cgaagggtaa tcggttttac tttttccttt tcagcatagc tttcctcgca
     2221 gagttggccc atttccgcaa acgccagaaa aatcagcgcg acggccgcaa aaggggagcg
     2281 ggaattgcag gatgcaatct ctgtaacaag cgtagcgggt ttgcttacac cctccggtta
     2341 aggaatgtac aatcaaacca gttgacgcct gaattgggca gttaatgacc tttttaccct
     2401 accagtgttt aaatttgtga tcaacttcac acatggattt cgtttaggac tcattgatgt
     2461 aactgattat ttacgccaaa tttacagaga agatttcctc gagcattgcc cccgccagac
     2521 gctgcgctga acagagtcgt ggcatcccca gcgcgacagt ttgccagcgt tgggtcactg
     2581 accagcaaac gggttgttta tctgccgtgg tccactttcc cagccaactt aaaaaatcag
     2641 catgctcccc gcccgtcgga acggtcgaag aggcaaacca ctgatggtaa tagtgacgcg
     2701 tggtcggtgc cgcattgata ctctctgcca gatgttgtgt cgctttctcg agcaaatcac
     2761 ccagcaacaa cgccaccgct tgcgggcttc ccagacggca ggcatcgcca aatgcccccc
     2821 agcgcaactc ctccagaacg ataaaacagc gcccaggcaa cgaccaggcg ttatacgccc
     2881 cagcacgcca gcgggtaaaa atttgctcgc tctgatcacc tgcctgcacc agtaggcctc
     2941 gttgcgttaa cgccttttcc ttccagcgac aacgggctga aaaccactca tacaaggcgg
     3001 caatttgctg ggggagctcc gggaaagcag agtgctggcg gtgatccatt ttttgcagca
     3061 gcgccagatg ctgcgcgatc tgcgtcagtg ccagatgacc gggatccagc atcgacgcca
     3121 gtttttccac caatgtcaga cgcaggctaa gcggcgcatt taacatgccg ccgttcgtcc
     3181 atgtctgaag ctgcacacgc gaaagaagtt cctgcatcag tcgttcacga aactgctgct
     3241 gatgggcttg tggaaggcgg gcatcatcac cctgcgccag atccactaaa aagcggggat
     3301 aaaccgactc cagcacgcga ccggggccgt caagtaacgt cttggtcaat atcgttctgc
     3361 cgtgaaaagt gtttgaatat catcgcgtaa cagctgggcg tcggtgtaaa tccagccgtg
     3421 agtcatcaca gtctgctgca attgctgctg catcagcctg accaccgatt cattttgttg
     3481 acgcagagcc agactttcgc gtaaacgcgt ctgtaattcc gtcaaacatg aagcgaactc
     3541 agcgaaaaaa gtattcatgc ctgccgtaac agattcatcg acctgctctg ccagaacttt
     3601 agccatttgt tggcaataga gatcgacttc tgcgcttaat gctcgttgca acacactgta
     3661 atcaaccgtt tctgtcggtg atttctcatt tccccgtccc cagtcgggct gattcaacca
     3721 gcgcgaaaaa gtctcacgca caacgcctaa acgcgtgctc tgctcgtccg ttgcttcctg
     3781 gcgcgaaatg acttcactga acagctggcg agtgttgaag tggggaacta cgccgtgaaa
     3841 aacaggaaaa tgaaacccag gacgaaaccc tgactcgctc aattccattt tgacttgttg
     3901 ctcaatgggg cgaataacat cggttaacac ccggcaaagg gtggattcaa gctcggcaaa
     3961 acgcagcgta aagtcgcgac tgatggtgtt ctgcgccgtc tgtcacagtg tctcacagcg
     4021 ggtacgaatc tcgcttaacg gctccgaatc atcctgaaac aaggcggcta actgcacctt
     4081 cagcgcatct tgctgttgac gcagaaagtg gttggcggag gtcagggcca gctcgatttc
     4141 atgtttaatc tcgccgctca cctgcgcctg attgagttgc aatagctgca aactttcttc
     4201 gatctggtgg atattttgcc gcaattgttc acaagcgacg tttaacccgt gcgcacgaaa
     4261 atccaggtat tcccgcgcct gctgcgcgta attcaacagt ttatgcgcgg cagatcgcag
     4321 agcatacaac gaggcgttag cgtaagcggc atgaagcaac gcctgaattg gctgggcggc
     4381 cagcgaatct tcccacaact gatcggcagc atgacgaata tgttcgaggt ccgccagatc
     4441 ggcatgacgc cagcgcctgc caagcgcggc atgggcaaaa tcttccaccc agcgttgttg
     4501 ctctggcggt ggtaacttac cgttgttggc taactcatag cgcgcccgat tcgccaggta
     4561 gccccacatc gacgacaccg gaaatatctg ctgtggcgta atacagcctt tcatcagcgt
     4621 cccggaaatc agtgcccgca cctggtcggc gtcgtcactg ttacgatcct gttgatcgaa
     4681 cttattgacc agcacgtaca gcggcaccga ttgccccacc gccaaaatcg cctcacggac
     4741 ctcttcatcg gagatcgatt tcagttgcgt ataatccagc accgccagta ccgccgaggc
     4801 gcgtgccagc tgctggttaa gcattttttg cagatgcggt tgcccggctt catttggccc
     4861 gggggtatcc agtaacgtca actgaccggg ataactctcc agccccgcta gatggacaaa
     4921 ctccacttca atcacgggaa tatgctcaat ggcggcgtaa gcagaaaaag gaaaatcgac
     4981 gtccagcgcc ttcgccagtc gcactaaatc attcaaactt ttcagacaat gaaaaatagg
     5041 ctgggcaccc agataatatt tttcgaaagc gacgccattt tcgatccgct gcataagcgc
     5101 acgcatatct ttatctattt ccagcacatc ggtcagatgc ttaatatcgc aatcacgcag
     5161 gcgctgttgt aattgttgaa ttaaacaatc gattggcgcg acatgtgaaa aatgcagtac
     5221 cggttccttt tgcccgggcg tatggcgaat aagcgtcggc agcgcagtca ttgggcgatt
     5281 acgattaggc agaacctccg taccaacaat ggcattaatg gtggttgatt tccctgcttt
     5341 catggtaccg acaattgcaa gcaccatttc cagtcgggaa attttacgca actcattatt
     5401 cagcatcgcg tgacgttcgg cgatattagg ctgactccag ggtaaagcca gttgtggcgc
     5461 gtcgtctccg ggtacagaga gaggcatttt ttccagtaac tgcaactgtt ggcgagaaag
     5521 ctgtaacagg cgttcagcct cctgacttaa ctcatacagg gtctgtgtgt acatagaaaa
     5581 ttcttcctta aagcaaatta tgttatttta tttagccaga ttgtttttga gttctgtttt
     5641 cggcttttat aattactgca agaaataatt ttatatttag tgtgttgttt tttatcagaa
     5701 taaataacgt cttctgatac gtttaaaacg tcagaaagat aaaaatatca tgtgaattaa
     5761 aaaaagaaca agtagagcat taacattatc ttaaataata aatagaggca aaaagattat
     5821 tttctttttg cgtttccttt caaatgaaaa cgatcgtcgt ctaaaatcag cagtaccccc
     5881 gacaaactca gggattttgt gtataattgc ggcctttttc ggcaatctgc cgttttttgg
     5941 cgcttttgcc ctgctgactt ttgaggaaat ccacatgtca ttaccacact gcccaaaatg
     6001 caactccgaa tacacctacg aagataacgg catgtacatc tgcccggaat gtgcctacga
     6061 atggaacgac gcagaacctg cacaggaaag cgacgagctg atcgttaaag atgctaacgg
     6121 caatctgctg gctgacggcg acagcgttac catcattaaa gatctgaagg tgaaaggtag
     6181 ctcttcgatg ctgaaaattg gcaccaaagt gaaaaacatc cgcctggttg aaggcgacca
     6241 taacatcgat tgcaaaatcg acggttttgg tccgatgaaa ctgaaatctg agtttgtgaa
     6301 aaagaactga ttgtattgtg atcggtaagc cggataaggc gctcgcgccg catccggcaa
     6361 cggtgccgac tgcctgatgc gacgcttgcg cgtcttatca ggcctacaaa ttcccgcacc
     6421 ctccgtaggc cggataaggc gtttacgccg catccggcaa cagtgccaac tgcctgatgc
     6481 gacgcttgcg cgtcttatca ggcctacaaa ttcccgcacc atccgtaggc cggataaggc
     6541 gtttacgccg catccggcaa cggtgccgac tgcctgatgc gacgcttgcg cgtcttatca
     6601 ggcctacaaa ttcccgcacc ctccgtaggc cggataaggc gtttacgccg catccggcaa
     6661 tggtgccgac tgcctgatgc gacgcttgcg cgtcttatca ggcctacaaa ttcccgcacc
     6721 ctccgtaggc cggataaggc gtttacgccg catccggcaa cagtgccgac tgcctgatgc
     6781 gacgctcgcg cgtcttatca ggccgcctct catctgtata aatttcgaac tacacttaac
     6841 tggcttctct taactgaggt caccatcatg ccgttaagtc cctacctctc ttttgccggt
     6901 aactgttccg acgcgattgc ctattatcaa cgtacgttgg gcgcggaact gctctataaa
     6961 atcagcttcg gcgaaatgcc aaaatcagcg caggacagcg ccgaaacgcc cttccggaat
     7021 gcaatttccc gataccgcca tcgcccacgc caatgtgcgc attgccggaa gcgacatcat
     7081 gatgagcgat gccatgccgt caggaaaagc cagctactcc ggctttacgc tggtgctcga
     7141 ttcgcaacag gtcgaagaag gaaaacgctg gtttgacaat cttgccgcta acggaaaaat
     7201 cgaaatggcc tggcaggaaa ctttctgggc gcatggcttt ggcaaagtca ccgataaatt
     7261 tggcgtaccg tggatgatta atgtcgtcaa acaacaacca acgcaataac ccgccgggag
     7321 gcccgccctc ccgcactgtc atcgaattcc cgttaactct tcatctgtta gtcactttta
     7381 attaaccaaa tcgtcacaat aatccgccac gatggagcca cttttttagg gaggctgcat
     7441 catgcaaacg attatccgtg tcgagaagct cgccaaaacc ttcaatcagc atcaggcgct
     7501 gcatgcggtt gatctgaaca ttcatcacgg tgaaatggtg gctctgcttg ggccgtcggg
     7561 ttccggaaaa tccacccttt tacgtcactt aagcggtttg attaccggcg ataaatctgt
     7621 cggtagccat atcgagctgc tgggccgcac agtccagcgc gaaggccgcc tggcccgcga
     7681 tatccgcaaa agccgcgccc ataccggcta catattccaa caattcaacc tggtgaaccg
     7741 cctgagcgta ctggagaacg tgctgattgg cgcgctcggc agcacgccgt tctggcgcac
     7801 ctgttttagc tggttcaccg gcgagcagaa acagcgcgcg ttacaggcgc tgacccgcgt
     7861 tggcatggtg cattttgccc atcagcgcgt ttccaccctc tccggcggcc agcagcaacg
     7921 tgtggcgatt gcccgtgcgc tgatgcagca ggcgaaagtg attctggccg atgaacccat
     7981 cgcctcgctg gacccagaat cagcgcgcat cgtgatggac accctgcgcg acatcaacca
     8041 gaacgacggc atcaccgtgg tcgtcacgct gcatcaggtg gattacgccc tgcgctactg
     8101 cgaacgcatc gtcgccctgc gccaggggca cgtcttctac gacggcagca gccaacagtt
     8161 tgataacgaa cgttttgacc atctctaccg cagcattaac cgcgtcgaag agaacgcgaa
     8221 agctgcctga catccccatc attgaggaaa acgaatgaac gctaagataa ttgcctcgct
     8281 ggccttcacc agcatgttca gcctcagcac cctgttaagc ccggcgcacg ccgaagagca
     8341 ggaaaaggcg ttgaatttcg gcattatttc aacggaatca cagcaaaacc tgaaaccgca
     8401 atggacgccg ttcttgcagg atatggagaa gaagctgggc gtgaaggtca acgccttctt
     8461 tgccccggac tacgcgggca ttatccaggg atgcgcttca ataaagtgga tatcgcctgg
     8521 tacggcaatc tgtcggcgat ggaagcggtg gatcgcgcca atggccaggt cttcgcccag
     8581 acggtcgcgg cggatggatc gccgggttac tggagcgtgt tgatcgtcaa caaagacagt
     8641 ccgatcaaca acctgaacga tctgctggcg aagcggaaag atctcacctt tggcaatggc
     8701 gatcctaact ccacctctgg cttcctcgtc cccggctact acgtcttcgc caaaaacaat
     8761 atctccgcca gcgacttcaa gcgcaccgtc aacgccgggc atgaaaccaa cgcgctggcc
     8821 gtcgccaaca agcaggtgga tgttgccacc aacaacaccg aaaacctcga caagctgaaa
     8881 acctccgcgc cagagaagct gaaagaactg aaggtgatct ggaagtcgcc gctgatccca
     8941 ggcgatccga tcgtctggcg caagaatctt tccgaaacca ccaaagacaa gatctacgac
     9001 ttctttatga actacggcaa aacgccggaa gaaaaagcgg tgctggaacg cctgggctgg
     9061 gcgccattcc gcgcttccag cgacctgcaa ctggtgccga ttcgccagct cgcgctgttt
     9121 aaagagatgc agggcgtgaa aagcaataaa ggactgaatg agcaggacaa gctggcaaaa
     9181 accaccgaga ttcaggcgca gctggatgac ctggaccgcc tgaacaacgc gctaagcgcg
     9241 atgagttcgg tgagtaaagc ggtgcagtaa atcgtaggtc ggataagacg ccccggcgtc
     9301 gcatccgaca atgtgcaggc gttgatgccg gatgcggtgc aagcacctta tccggcctac
     9361 agaccggagc caaacatgca aaccatcacc atcgccccac ccaagcgcag ctggttctcg
     9421 cttctgagct gggccgttgt actcgccgtg ttggtcgtct cgtggcaggg cgcggaaatg
     9481 gccccgctta cgctgatcaa agacggcggc aacatggcga cgttcgccgc cgacttcttc
     9541 ccgcccgatt tcagccagtg gcaggattac ctcaccgaaa tggccgtcac gctgcaaatc
     9601 gccgtctggg gcaccgcgct ggcggtggtt ctctccatcc cctttggcct gatgagcgcc
     9661 gaaaacctgg tgccgtggtg ggtttaccag cccgttcgcc gcctgatgga cgcctgccgc
     9721 gccattaacg aaatggtctt cgccatgctg ttcgtggtcg ccgtcggcct cggcccgttc
     9781 gctggcgtgc tggcgtgctg gcgctgttta tccacaccac cggcgtgctc tccaagctgc
     9841 tttccgaagc ggtggaagcg attgaacccg gcccggtgga aggcattcgc gccaccggtg
     9901 ccaacaagct cgaagagatc ctctacggcg tgctgccaca ggtgatgcca ctgctgatct
     9961 cctactccct ctatcgcttc gaatccaacg tccgctcggc gaccgtcgtc ggcatggtcg
    10021 gcgcaggcgg gatcggcgtc accctgtggg aagcgattcg cggtttccag ttccaacaaa
    10081 cctgcgccct gatggtgctt atcatcgtca cggtcagcct gctggatttc ctctctcaac
    10141 ggttgcgtaa gcactttatc tgataagcga ggcattgata tctatgcact tgtctacaca
    10201 tccgaccagc tacccaacac gctatcaaga gatagccgca aaacttgagc aggagcttcg
    10261 tcaacactac cgctgcggcg actatcttcc cgccgagcag caactggcag cgcgctttga
    10321 ggtgaatcgc cacaccctgc gccgcgccat cgaccaactg gtggaaaaag gctgggtaca
    10381 gcgccgtcag ggcgtcggcg tgctggtgct gatgcgcccg ttcgattacc cgctcaacgc
    10441 ccaggcgcgt tttagccaga atctgctgga tcagggcagc catcccacca gcgaaaaact
    10501 gctttcggta ttgcgccccg cgtccggcca cgtcgctgac gcactgggga ttaccgaggg
    10561 gagaacgtca tccacctgcg caccctgcgt cgtgtcaacg gcgtcgcgct ctgtttaatc
    10621 gaccactact tcgcggacct caccctctgg ccgacgctgc aacgcttcga cagcggctcg
    10681 ctgcacgatt ttctgcgcga gcaaaccgga attgcgctgc gccgcagcca gacgcggatc
    10741 agcgcccgcc gcgccaggcc aaagagtgcc agcgtcttga aatcccgaat atgtcgccgc
    10801 tgctgtgcgt gcgcaccctt aaccaccgtg acggtgaaag cagcccggcg gagtactccg
    10861 tcagcctgac gcgcgccgac atgattgaat tcactatgga gcactgaatg cacgcagata
    10921 ccgcgacccg ccagcactgg atgtccgtgc tggcgcacag ccaaccggct gaactggcag
    10981 cacgcctgaa cgcgctaaac atcaccgccg actatgaggt gatccgcgcc gctgaaactg
    11041 gcctggtaca gattcaggcg cgaatgggcg gcaccggcga acgttttttt gccggcgacg
    11101 ccacgctgac ccgcgccgcc gtgcgcctga ctgacggcac gctcggctac agctgggtgc
    11161 aggggcgtga taaacagcac gccgaacgct gcgcgctgat tgacgcgctg atgcagcaat
    11221 ctcgccactt tcaaaactta tcagaaaccc ttattgcccc gctggacgct gaccgtatgg
    11281 cacgcattgc cgcacgccag gccgaagtga acgccagccg ggtcgacttc tttacgatgg
    11341 ttcgcggaga caacgcatga ccctggaaac cgcttttatg cttcccgtgc aggatgccca
    11401 gcacagtttt cgtcgcctgt taaaggccat gagcgagccg ggcgtgattg tcgccctgca
    11461 tcagctcaaa cgcggctggc aaccgctgaa tatcgccacc accagcgtgc tgctgacgct
    11521 ggccgataac gacacgccgg tgtggctttc taccccatta aataacgata tcgtcaacca
    11581 gagcctgcgt tttcatacca acgcgccgct ggtcagccag ccggaacagg cgaccttcgc
    11641 ggtgacggat gaggcgattt ccagcgaaca gctcaacgcc ctttccaccg gcaccgccgt
    11701 tgcgccggaa gcgggtgcga cgctgatttt acaggtcgcc agcctgagcg gcggacgcat
    11761 gttgcgcctt actggtgcgg gtattgccga agaacgaatg atcgctccgc agctgccgga
    11821 gtgcattctg cacgaactca ccgagcgccc gcatccgttc ccgctcggca tcgacctgat
    11881 cctgacctgt ggcgagcgcc tgctggctat tccgcgaacc actcatgtgg aggtgtgctg
    11941 atgtacgttg ccgtgaaagg gggcgagaag gcgatcgacg ccgcccacgc cctgcaagag
    12001 agccgacgcc gaggcgatac cgatttgccc gaactgagcg tcgcccagat tgaacagcag
    12061 cttaacctcg cggtagatcg cgtgatgacc gaaggcggca ttgccgaccg cgaactggcg
    12121 gcgctggcgc tgaaacaggc cagcggcgat aacgttgaag cgattttcct gctgcgcgcc
    12181 taccgcacca cgttggcgaa gctggcggta agcgagccgc tcgacaccac cgggatgcgt
    12241 ctcgaacgcc gtatctccgc cgtttataaa gacattcccg gcggccagct gcttggccca
    12301 acctacgact acacccatcg cctgctcgat tttaccctgc tggcaaacgg cgaagcgccg
    12361 acgctgacca ccgccgacag cgaacagcag ccgtcgccgc acgttttcag cctgctggcg
    12421 cgtcaggggc tggcgaagtt tgaagaggat agcggcgcac agccggatga catcacccgc
    12481 acgccgccgg tttacccctg ctcacgctcc tcccgtttgc agcagttgat gcgcggcgac
    12541 gaaggctatt tgctggcgct ggcctactcc acccaacgcg gttacgggcg caatcacccg
    12601 ttcgcaggcg agatccgcag cggctatatc gacgtgtcga ttgtgccgga agagctggga
    12661 tttgcggtga acgtcggcga actgctgatg actgagtgtg aaatggttaa cggttttatc
    12721 gacccgccgg gtgagccgcc gcacttcacg cgcggctacg ggctggtgtt cggcatgagc
    12781 gagcgcaaag cgatggcgat ggcgctggtc gaccgcgctc tgcaagcccg gagtacggcg
    12841 agcacgcgac aggcccggcg caggatgaag agttcgtgct ggcacatgcc gacaacgtcg
    12901 aagccgcagg ctttgtctca cacctcaaac tcccccacta cgtcgatttc caggccgaac
    12961 tggagctact caaacgtctg caacaggagc agaaccatgg ctaatctgag cggctacaac
    13021 tttgcctacc tcgacgagca gaccaaacgc atgatccgcc gcgccatctt aaaagcggtg
    13081 gcgatccccg gttatcaggt gccgtttggc gggcgcgaga tgccgatgcc gtacggctgg
    13141 ggaaccggcg gcattcagct taccgccagc gtgattggcg aaagcgacgt gctgaaggtg
    13201 attgaccagg gcgcggatga caccaccaac gccgtgtcga ttcgcaactt cttcaagcgc
    13261 gtgaccgggg taaacaccac ggaacgtacg gacgatgcga cggttatcca gacgcgtcac
    13321 cgcatccccg aaacgccgct gaccgaagat cagataatta tcttccaggt gccaatcccc
    13381 gagccgctgc gctttatcga gccgcgcgaa acggaaaccc gcaccatgca cgcgctggaa
    13441 gagtacggcg tgatgcaggt gaaactgtat gaagatatcg cccgcttcgg tcatatcgcc
    13501 accacctacg cctatccggt gaaggtaaat gggcgctacg tgatggaccc gtcgccgatc
    13561 ccgaaattcg ataacccaaa aatggacatg atgcccgccc tgcaactgtt cggcgcgggg
    13621 cgcgagaagc gcatctatgc ggtgccgccg tttacccgcg tggaaagtct cgatttcgac
    13681 gatcacccgt tcaccgttca gcagtgggat gagccatgcg ccatctgcgg atcgacccac
    13741 agctatcttg atgaagtggt gctggatgac gccggaaacc gcatgtttgt ctgctccgat
    13801 accgattatt gccgccaaca gagcgaggca aaaaaccaat gaatcaaccg ttactttcgg
    13861 tcaataacct gacccacctt tacgcgccgg gcaaaggctt tagcgatgtc tcttttgatt
    13921 tatggccggg ggaagtgctg ggcattgtcg gggaatccgg ctccgggaag accacgctgc
    13981 tgaagtcgat ctccgcgcgc ctgacgccgc agcaggggga aattcactac gagaaccgtt
    14041 cgctgtatgc aatgagcgag gccgaccgcc gtcgcctgct gcgtaccgaa tggggcgtgg
    14101 tgcatcagca tccactcgac ggcctgcgcc gccaggtgtc ggcaggcggc aatatcggcg
    14161 agcggctgat ggcgaccggg gcacgtcatt acggcgatat tcgtgccacc gcgcagaagt
    14221 ggctggaaga ggtggagatt cccgccaacc ggatcgacga cctgccgacc accttttccg
    14281 gcggtatgca gcagcgtttg cagattgccc gcaacctggt gacgcatccg aagctggtgt
    14341 ttatggatga accgaccggc gggctggatg tgtcggtgca ggcccgcctg ctcgacctgc
    14401 tgcgcggcct ggtggtggag ctgaacctcg cggtggtgat tgtcacccat gatttaggcg
    14461 tcgcccgcct gctggcggac cgtttgctgg tgatgaagca ggggcaagtg gtggagagtg
    14521 ggttaaccga ccgcgtgctc gacgacccgc atcatccgta tacacagctg ctggtgtcat
    14581 cggttttgca gaattgagcc ggtgccggat gcggcgtaaa cgccttatcc ggcctacaaa
    14641 tgcgctcccc gtaggtcgga taagacgcgt cagcgtcgca tccgacaccc ggaaccacga
    14701 ggcgaaaaat gattaacgta caaaacgtca gtaaaacctt catcctgcac cagcaaaacg
    14761 gcgtgcgcct gcccgtcctc aatcgcgcct cgctcaccgt caacgcgggc gaatgcgtgg
    14821 tgctccacgg ccattccggc agcggcaaat caactctgct acgctcgctg tacgccaact
    14881 atctgcccga cgaaggtcaa atccagatca aacacggtga cgagtgggta gacctggtca
    14941 ccgcgccagc gcgcaaagtg gtggaaatcc gcaaaaccac cgtcggctgg gtgagccagt
    15001 ttctgcgcgt catcccgcgt atctcagcac tggaagtggt gatgcagccg ctgctcgata
    15061 ccggcgttcc gcgtgaagcc tgcgccgcta aagccgcgcg tcttctcacc cgcctgaacg
    15121 tgccggaacg cctgtggcac tggcaccatc gacattttcc ggtggcgaac agcagcgcgt
    15181 caacatcgcc cgcggcttta tcgtcgacta ccccattctg ctgcttgacg aacctaccgc
    15241 ctcgctggac gccaaaaaca gcgccgcggt ggtggaactg attcgcgaag ccaaaacccg
    15301 tggcgcagcc atcgtggcat cttccatgac gaagctgtac gtaatgacgt cgccgaccgc
    15361 ctgcacccaa tggagcctct tcatgattat caataacgtt aagctggtgc tggaaaacga
    15421 ggtggtaagc ggttcgctgg aggtgcagaa cggcgaaatc cgcgcctttg ccgaaagcca
    15481 gagccgcctg ccggaggcga tggacggcga aggcggctgg ctgccgccgg ggctgattga
    15541 gctgcatacc gataatctgg ataaattctt caccccgcgc ccgaaagttg actggcctgc
    15601 ccactcggcg atgagcagcc acgacgcgct gatggtggcg agcggcatca ccaccgtact
    15661 ggatgccgtg gcaattggcg acgtgcgcga cggcggcgat cggctggaga atctgagaag
    15721 atgatcaacg ccatcgaaga gacgcagaaa cgcggcgtca accgcgccga gcaccgtctg
    15781 catctgcgct gcggctgccg catcacacca cgctgccgct gtttgaaaaa ctggtgcagc
    15841 gcgagccggt gacgctggtg tcgctgatgg accactcgcc gggccagcgc cagttcgcca
    15901 accgcgagaa gtatcgcgaa tattatcagg gcaaatactc cctcactgat gcgcagatgc
    15961 agcagtacga agaagagcaa ctggcgctcg ccgcacgctg gtcgcagccg aatcgcgaat
    16021 ccatcgccgc cctgtgccgc gcgaaaaatt gcgcttgcca gccacgatga cgccacccac
    16081 gcccacgttg ctgaatctca ccagcttggc agcgtgatcg ccgaatttcc caccacgttc
    16141 gaagcggcgg aagcctcgcg caagcatggc atgaacgtgc tgatgggcgc gccgaatatt
    16201 gtgcgcggcg gctcgcactc cggcaacgtg gcggccagtg aactggcgca gcttggcctg
    16261 ctggatatcc tctcttccga ctactacccc gccagcctgc tcgatgcggc atttcgcgtc
    16321 gccgatgacc agagcaaccg ctttacgctg ccgcaggcgg tgaagctggt gactaaaaat
    16381 ccagcgcagg cgcttaatct ccaggatcgc ggggtgattg gcgagggcaa acgcgccgac
    16441 ctggtgctgg cgcatcgcaa ggacaatcat attcatatcg accacgtctg gcgtcagggt
    16501 aaagtgggtg ttctgatgat gggaaaactg atttggttaa tggggccgtc cggctccggg
    16561 aaagacagcc tgctggcgga actccgcctg cgggaacaaa ctcagttact ggtggcgcat
    16621 cgctacatca cgcgcgatgc cagcgccgga agtgaaaacc atatcgccct gagcgagcag
    16681 gagtttttta cccgcgcggg gcaaaatctg ttggccttaa gctggcacgc taacggtctg
    16741 tattatggcg tcggcgtcga gattgatctc tggctgcacg ccggattcga cgtgctggtc
    16801 aacggctcac gcgcccatct gccgcaggcg cgggcgcgct atcaatcggc gctgctgccc
    16861 gtctgtttac aggtttcgcc ggagatcctc cgccagcgca cggaaaaccg tggccgtgaa
    16921 aacgccagtg aaattaacgc ccgcctggcg cgcgccgccc ctatactcca caggattgcc
    16981 atacgctcaa caatgacggc agcctgcgcc agtcggtcga cacgctgctg acgctgatcc
    17041 atcagaagga gaaacaccat gcctgcttgt gagcttcgcc cggccacgca gtacgacacc
    17101 gacgcggttt acgctgattt gtgagctaaa acaggcgggt ttgaccacca cgcgtttcgc
    17161 gtgggtttta acgccaatct gcgcgaccca aacatgcgct accatctggc gctgcttgat
    17221 ggcgaagttg tcggcatgat cggcctgcat ttgcagtttc atctgcatca tgtcaactgg
    17281 atcggcgaaa ttcaggagtt ggtggtaatg ccgcaggcgc gcggtctgaa cgtcggcggt
    17341 aagttactgg cattgggcag aagaagaagc ccgccaggcc ggggccgaaa tgaccgaact
    17401 ttcgaccaac gtgaagcgcc acgacgcgca ccgtttctat ctgcgcgaag gctacgagca
    17461 gagccacttc cgcttcacca aggcgctgta acatgagcct gaccctcacg ctcaccggca
    17521 ccggcggcgc acagggcgtt ccggcatggg gctgcgagtg tgcggcctgc gccagagcgc
    17581 ggcgctcgcc gtatcgccgc caaccgtgca gcggcgtagt gaagtttaac gacgcaatca
    17641 ccctgatcga cgccgggctg cacgatctcg ccgatcgctg gtcgcccgga tcgttccagc
    17701 agtttttgct gacgcattat catatggatc acgtccaggg gctgtttccg ctgcgctggg
    17761 gcgttggcga tccgatcccg gtttacggcc cgccggatga acagggctgc gacgatctgt
    17821 ttaaacatcc gggcctgctt gatttcagcc acacggtgga accgtttgtg gtgtttgatt
    17881 tgcaggggtt acaggtcacg cccctgccgc tcaaccactc aaaactgacc ttcggttatc
    17941 tgctggaaac ggcacacagc cgggtggcat ggctgtctga caccgcaggc ttgccggaaa
    18001 aaacgctgaa atttttacgc aataatcagc cgcaggtaat ggtgatggat tgcagtcacc
    18061 cgccgcgcgc ggatgcaccg cgtaatcact gtgatttaaa taccg
//
