LOCUS       NZ_CP083003             9294 bp    DNA     circular CON 10-FEB-2024
DEFINITION  Klebsiella pneumoniae strain 6712.08 plasmid p3-6712.08, complete
            sequence.
ACCESSION   NZ_CP083003
VERSION     NZ_CP083003.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN21016529
            Assembly: GCF_021137715.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 9294)
  AUTHORS   Campos-Madueno,E.I. and Endimiani,A.
  TITLE     A collection of hybrid assemblies of carbapenemase-producing
            Klebsiella pneumoniae clinical isolates from Switzerland
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9294)
  AUTHORS   Campos-Madueno,E.I. and Endimiani,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-SEP-2021) Institute for Infectious Diseases,
            University of Bern, Friedbuehlstrasse 51, Bern 3001, Switzerland
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. 0.4.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 197.2725x
            Sequencing Technology :: Illumina NovaSeq and Oxford Nanopore MinION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/10/2024 03:13:57
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,607
            CDSs (total)                      :: 5,487
            Genes (coding)                    :: 5,358
            CDSs (with protein)               :: 5,358
            Genes (RNA)                       :: 120
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 86
            ncRNAs                            :: 9
            Pseudo Genes (total)              :: 129
            CDSs (without protein)            :: 129
            Pseudo Genes (ambiguous residues) :: 0 of 129
            Pseudo Genes (frameshifted)       :: 56 of 129
            Pseudo Genes (incomplete)         :: 64 of 129
            Pseudo Genes (internal stop)      :: 28 of 129
            Pseudo Genes (multiple problems)  :: 15 of 129
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP083003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..9294
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="6712.08"
                     /host="Homo sapiens"
                     /db_xref="taxon:573"
                     /plasmid="p3-6712.08"
                     /geo_loc_name="Switzerland"
                     /lat_lon="46.947928 N 7.422277 E"
                     /collection_date="2018"
                     /collected_by="Institute for Infectious Diseases (IFIK),
                     University of Bern, Friedbuehlstrasse 51, 3001 Bern,
                     Switzerland"
     gene            complement(join(8773..9294,1..1443))
                     /locus_tag="K9F30_RS27795"
                     /old_locus_tag="K9F30_27755"
     CDS             complement(join(8773..9294,1..1443))
                     /locus_tag="K9F30_RS27795"
                     /old_locus_tag="K9F30_27755"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004178196.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TraM recognition domain-containing protein"
                     /protein_id="WP_004178196.1"
                     /translation="MFNTDSLAWKWHIPELARQIYPWVSWLYQEYYGLAGAFLVIGLFF
                     GLAELWAGRMRFVGLSHKERREYADRYKRDNKRPAPFSVLASLDSPGRMVRARRHVWNY
                     AYWLTGAAGLALLGGLVVAVFIESWGETVLRPDLYANADYYLLQPANLFGIAWCAGGLA
                     VGIVLARLLAFLLLDGHFAAADEAVNAKLNQESRRSSQRTGEMTDVRHLHFGEPVPVNA
                     LADFSSEQARQEQAVFLGKDEQGKPVLVPRDTWRKTNIQILGLPGSGKSVMATNALIRC
                     VRDFGDAVVYFDPKGDAWAPHVFRAHCPDFTLLDLRPGKPAQLNLFRDLDQYALKNLLI
                     AGLNLGETGDVADHYRISEQKAAKLIAEQFPQGANIQQVLAAAYALPEALKKDVKGLIT
                     RLENVADLSVLQTDSGIDVAGIINGGGCLYVIGSMDDEAVIRVQKMLFARCAQIIIARD
                     EFREWPHVSVMLDEIKYLLSKYVLNALGTLRSRDCNLLLAHQSLGDFGQCGQDLPAEFV
                     KTTVLDNTPIRWFYRAASLESAQWAAGQTGEIRVDVERRRASREAGNVEHISGDSFIQK
                     EARPLFDVNTLQHLPDGFAVMTGLGVARMAFSSPLRVERREIPLQRFPVLAKTDPLAEF
                     RPPADGGGPKADDDFAGIY"
                     /name="TraM recognition domain-containing protein"
     gene            complement(2924..3073)
                     /locus_tag="K9F30_RS27800"
                     /old_locus_tag="K9F30_27760"
     CDS             complement(2924..3073)
                     /locus_tag="K9F30_RS27800"
                     /old_locus_tag="K9F30_27760"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891188.1"
                     /GO_component="GO:0019867 - outer membrane [Evidence IEA]"
                     /GO_process="GO:0019835 - cytolysis [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin release lysis protein"
                     /protein_id="WP_004152552.1"
                     /translation="MKKVKVVFLFILIFSGFLLVACQANYIRDVQGGTVAPSSSSELTG
                     IAVQ"
                     /name="colicin release lysis protein"
     gene            complement(3158..3415)
                     /locus_tag="K9F30_RS27805"
                     /old_locus_tag="K9F30_27765"
     CDS             complement(3158..3415)
                     /locus_tag="K9F30_RS27805"
                     /old_locus_tag="K9F30_27765"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin immunity family protein"
                     /protein_id="WP_004152553.1"
                     /translation="MGLKLHIHWFDKKTEEFKGGEYSKDFGDDGSVIESLGMPLKDNIN
                     NGWFDVEKSWVSILQPHFKNVIDISKFDYFVSFVYRDGNW"
                     /name="cloacin immunity family protein"
     gene            complement(3425..5110)
                     /locus_tag="K9F30_RS27810"
                     /old_locus_tag="K9F30_27770"
     CDS             complement(3425..5110)
                     /locus_tag="K9F30_RS27810"
                     /old_locus_tag="K9F30_27770"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin-like bacteriocin tRNase domain-containing
                     protein"
                     /protein_id="WP_004178188.1"
                     /translation="MSGGDGRGPGNSGLGHNGGQASGNVNGTSGKGGPSSGGGTDPNSG
                     PGWGTTHTPNGDIHNYNPGEFGNGGSKPGGNGGNSGNHSGSSGGGQSSATAMAFGLPAL
                     ATPGAEGLALSVSGDALSAAVADVLAALKGPFKFGLWGIAIYGVLPSEIAKDDPKMMSK
                     IVTSLPADTVTETPVSSLPLDQATVSVTKRVADIVKDERQHIAVVTGRPMSVPVVDAKP
                     TKRPGVFSVSIPGLPSLQVSVPKGVPAAKAPPKGIIAEKGDSRPAGFTAGGNSREAVIR
                     FPKESGQKPVYVSVTDVLTPAQVKQRLEEEKRRQQAWDAAHPEEGLKREYDKAKAELDA
                     EDKNIATLNSRIASTEKAIPGARAAVQEADKKVKEAEANKDDFVTYNPPHEYGSGWQDQ
                     VRYLDKDIQNQNEKLKAAQTSLNEMNESLSRDKAALSGAMESRKQKEKKAKDAENKLNE
                     EKKKPRKGTKDYGHDYFPDPKTEDIKGLGELKEGKPKTPKQGGGGKRARWYGDKKRKIY
                     EWDSQHGELEGYRASDGEHLGAFDPKTGKQVKGPDPKRNIKKYL"
                     /name="colicin-like bacteriocin tRNase domain-containing
                     protein"
     gene            5513..5932
                     /locus_tag="K9F30_RS27815"
                     /old_locus_tag="K9F30_27775"
     CDS             5513..5932
                     /locus_tag="K9F30_RS27815"
                     /old_locus_tag="K9F30_27775"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016247941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Exc2 family lipoprotein"
                     /protein_id="WP_001254601.1"
                     /translation="MRRSGSKLCLIAMITATATLTACAPKGSVEQHTRHYVYASDDGFD
                     PNFSTQKADTTRMMVPFFRQFWDMGAKDKATGKSRSDVQQRIQQFHSQEFLNSLQGTTQ
                     FAGTDYRSKDLTPKKSRLLADTISAVYLDGYEGRQ"
                     /name="Exc2 family lipoprotein"
     gene            6238..6501
                     /locus_tag="K9F30_RS27820"
                     /old_locus_tag="K9F30_27780"
     CDS             6238..6501
                     /locus_tag="K9F30_RS27820"
                     /old_locus_tag="K9F30_27780"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000072676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000072676.1"
                     /translation="MSNTTHYENANFLRELAESLPRILPEGGPDKAALLQRLANEELAQ
                     AEYEDQVRAKVTAARADTRPGMTTEQLRQRLHGRYQELRDAV"
                     /name="hypothetical protein"
     gene            6491..6790
                     /locus_tag="K9F30_RS27825"
                     /old_locus_tag="K9F30_27785"
     CDS             6491..6790
                     /locus_tag="K9F30_RS27825"
                     /old_locus_tag="K9F30_27785"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001146176.1"
                     /GO_function="GO:0008657 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) inhibitor activity
                     [Evidence IEA]; GO:0042803 - protein homodimerization
                     activity [Evidence IEA]"
                     /GO_process="GO:0030541 - plasmid partitioning [Evidence
                     IEA]; GO:0051290 - protein heterotetramerization [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_001146176.1"
                     /translation="MPYDVEWKQGAIEDVTTLFDYIAENSSLWDAQNVTDRVLAAADKL
                     ADFPRLYEVDSRYGEDVRRISLMGQHVLYDVDDQTRKVRVLAVVGQRQNPHIVL"
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            complement(6852..7229)
                     /locus_tag="K9F30_RS27830"
                     /old_locus_tag="K9F30_27790"
     CDS             complement(6852..7229)
                     /locus_tag="K9F30_RS27830"
                     /old_locus_tag="K9F30_27790"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000312627.1"
                     /translation="MAWVTVRQATELTGKARSSLYRDMAKGRVSYRTEADGGRVVDTSE
                     LIRVYGELRQDETHERDELRLSGETEKMASDALIAEIKALREEVAGLRQEMQSMRLLEH
                     KPETAETPAGTPRRWWPWGKR"
                     /name="hypothetical protein"
     gene            7298..7477
                     /locus_tag="K9F30_RS27835"
                     /old_locus_tag="K9F30_27795"
     CDS             7298..7477
                     /locus_tag="K9F30_RS27835"
                     /old_locus_tag="K9F30_27795"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rop family plasmid primer RNA-binding protein"
                     /protein_id="WP_000165971.1"
                     /translation="MTKQEKTALNMAKFIKEQSLLLLDKLNELDMDTPADMCERLHEDA
                     ETLWQVMRDKLGEE"
                     /name="Rop family plasmid primer RNA-binding protein"
     gene            complement(7505..8035)
                     /locus_tag="K9F30_RS27840"
                     /old_locus_tag="K9F30_27800"
     CDS             complement(7505..8035)
                     /locus_tag="K9F30_RS27840"
                     /old_locus_tag="K9F30_27800"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_004153058.1"
                     /translation="MALYMVFIEDAEDRNGERCIMPTSEHLEDMVVLAWQTGAYVFCFV
                     DRAQHLAMMKSIGMYDERLNSDEKATYFFTGKNPQWERNKPTGMKLCDYLYRKVERFAI
                     ENGVQVVDAGKCSPEQINAMIDVVSERHGESAVNEKLKAELMREYNSRYFNVPVPELPE
                     DKPARRWWPFGKK"
                     /name="hypothetical protein"
     gene            complement(8042..8773)
                     /locus_tag="K9F30_RS27845"
                     /old_locus_tag="K9F30_27805"
     CDS             complement(8042..8773)
                     /locus_tag="K9F30_RS27845"
                     /old_locus_tag="K9F30_27805"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobC family replication-relaxation protein"
                     /protein_id="WP_004152551.1"
                     /translation="MALELYNVSHAKRQARNAEKTRLTLRWLREELCSTAELVARRLGI
                     AAVQPVYRFLDSLVAKGLLVRTKYPVDGRQVSVWGLTPHGVAFSFDEDEPLADVIPFQP
                     SRVSAAHLPHRLAVQSLRLDMEARGATGWRILHRLSLKGMKVPDALAELDGKTVAFEVE
                     RTVKSRRRYQEVVSGYLFNRKANGIDEIWYICPDRATQVRVQRAILSVDEIVNPQTGEA
                     RKTAELDRERLFACFKFMTTE"
                     /name="MobC family replication-relaxation protein"
     BGC             1..9294
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          2243..2821
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="95.361"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(8046..8773)
                     /name="MOBC"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="1.32e-150"
ORIGIN
        1 tacatacttc gacagcagat atttaatttc atcgagcatc acgctgacgt gtggccactc
       61 ccggaactcg tcccgcgcaa tgatgatttg cgcgcagcgg gcaaacagca ttttttgcac
      121 acggatcacc gcctcgtcgt ccatcgagcc gataacgtac aggcagccgc cgccgttgat
      181 aatccccgcc acatcgatgc cactgtccgt ctgcaggacg ctcaggtcag cgacgttttc
      241 cagcctagtg atcaacccct tcacgtcctt tttcagggcc tccggcagcg cgtacgccgc
      301 cgccagcacc tgctgaatgt ttgccccctg cggaaactgc tccgcaatca gcttcgccgc
      361 tttctgctcg ctgatgcggt agtggtccgc cacgtcgccg gtctcgccca ggttaagccc
      421 ggcaatcagc aggtttttca gcgcgtactg gtcgagatcg cggaacagat tcagctgcgc
      481 cggtttcccc ggccgcagat ccagcagggt gaagtccgga cagtgcgccc ggaagacgtg
      541 cggcgcccat gcgtcccctt tggggtcgaa gtacaccacc gcgtccccga aatcgcgtac
      601 gcagcgaatg agcgcgttgg tggccatcac gctcttgccg ctcccgggca ggccgaggat
      661 ctgaatgttg gtcttgcgcc aggtatcacg cggaaccagc accggcttgc cctgctcatc
      721 cttacccaga aacaccgcct gctcctgccg ggcctgctcc gaggaaaaat cggccagcgc
      781 attaaccggt accggctccc cgaaatgcag gtggcgcacg tcggtcatct ctcctgtccg
      841 ctggctgctg cgccggctct cctgattcag tttcgcgttc accgcctcgt cagcagccgc
      901 aaaatgaccg tcaagcagca ggaacgccag cagccgcgcc aacacaatcc cgacagccag
      961 cccgcccgcg caccaggcaa tcccgaacag gttagccggc tgcagcaggt aataatctgc
     1021 gtttgcgtag aggtccggac gcaggacggt ttctccccag ctctcgataa acacggcgac
     1081 aaccagcccc cccagaaggg ccagaccggc cgcgccggtc agccagtacg cgtagttcca
     1141 gacatgtcga cgtgccctga ccatccgccc gggcgaatcc agcgaggcca gcaccgaaaa
     1201 tggcgctggc cgtttattat cgcgcttata gcgatcggca tactcccgtc gctccttatg
     1261 actcagcccc acaaaacgca tccgtccggc ccaaagttca gccagaccga aaaacaggcc
     1321 gataactagg aaagccccgg ccagaccgta atactcctgg tacagccagc tgacccacgg
     1381 ataaatctgc cgggccagct ccggaatgtg ccacttccag gcaagcgaat ccgtattaaa
     1441 catgttctct ctccttcaga cgatggtttg ccggcgtgat gtgcagcccc cgctgcacaa
     1501 gccgcggaca tgccccaagg catggcggcg gcggtcacgt ccgtggtgat tgcgttcagc
     1561 tttcaccacg gaggccagcc tctttccgcc ccatgcggaa aaggcgcagc cccggaggaa
     1621 caacgagcac gccccagcgt gtgagaggaa aaggcggcac cccagtgcgg tcttttccgg
     1681 tgttccggcc cccgtcagag ttcgccatag cgagcggctg accacccgca aaatcaggag
     1741 cagctttgct gcttcgccag gtgcgtccag caccgtggat ttttgtgggt ggtcaggcgt
     1801 gagcctgacg ggggccgggt gaatttctgg cgtggccggc gtccagccgg acggagccag
     1861 aaagaggggg agagaccgtg cgtcggtggc gtccagccag cgtaagcagg ggatatcccc
     1921 ctgaggtcag ccacgccctc gcggggatga cctgtatttc tccgtaagga gaaaaaagca
     1981 acagagatag gttaacgtaa aatgttcagc gaaaaaccga tatgattcac ctatcctggt
     2041 aatttattat cagggaatat aaagacttaa tcaggggaca atatgccaca tcagcgcgtc
     2101 cggtgtccgt cttgtaggtg ccggggaaat tgcgcctcct cgctcactcg gtcgctacgc
     2161 tccggccgtg agactgcggc gggcgctgcg gacacatgca aagttaccca cagattccgt
     2221 gaataagcag gggactaaca tgtgaggcaa aacggcaagg ccacgcaggt ggcgtttttc
     2281 cataggctcc gccctcctga ctgagttcac ataaacagac gctttttcgg tgcatctgtg
     2341 ggagccggtg gctcaaccat gaatcagtca ggagtggcga aacccgacag gacttaaaga
     2401 tcatcaccgt ttccgatgaa tcgctccctc ttgcgctctc ctgttccaac cctgccgttt
     2461 cccggatacc tgttccgcct ttctcccttg cgggaagtgt ggcgctttct catagctcac
     2521 actctggtat ctcggctcgg tgtaggtcgt tcgctccaag ctgggctgta agcaagaacc
     2581 ccccgttcag cccgactgct gcgccttatc cggtaactgt tcacttgagt ccaacccgga
     2641 aaagcacgca aaacgccact ggcagcagcc attggtaact gggagttcgc agaggatttg
     2701 tttagctaaa cacgcggttg ctcttgaagt gtgcgccaaa gtccggctac actggaagga
     2761 cagatttggt tgctgtgctc tgcgaaagcc agttaccacg gttaagcagt tccccaactg
     2821 acttaacctt cgatcaaacc acctccccag gtggtttttt cgtttacagg gcaaaagatt
     2881 acgcgcagaa aaaaaggatc tcaagaagat cctttgatct tttctactga accgcgatcc
     2941 ccgtcagttc agaggaggac gatggtgcca ccgttccacc ctgaacatcc cggatatagt
     3001 ttgcctgaca tgcgaccaga agaaagcctg aaaaaatcaa tataaaaaga aaaacaacct
     3061 ttaccttttt catatacctt ccctgtattt aaaaaccccg gtattcatcc ctgaacaccg
     3121 gaagtctgta tttcaaatca tccttgataa cttttgctta ccagttacca tcccggtaaa
     3181 caaaggatac aaagtaatca aatttactaa tatcgattac atttttaaag tgtggctgta
     3241 atatcgaaac ccatgatttt tcaacatcaa accaaccatt attaatatta tcctttaaag
     3301 gcatccccag actttcaatg acagaaccat catcaccgaa gtcttttgag tattcaccac
     3361 ctttaaactc ttcggttttc ttatcaaacc aatgaatatg taatttaagc cccatattta
     3421 cctcttaaag atatttttta atgtttcgtt ttggatccgg ccctttaacc tgcttacccg
     3481 tttttggatc gaatgccccg aggtgttcgc catcactggc gcggtaccct tcaagctcac
     3541 cgtgctggga atcccattca taaattttac gctttttatc accataccat cgggcccgct
     3601 taccaccacc accttgttta ggggttttag gtttaccctc tttcaactct cccaacccct
     3661 taatatcttc agtcttggga tcaggaaaat aatcatggcc gtaatcttta gttcccttac
     3721 gaggtttttt cttttcctca tttaatttat tttctgcatc cttcgctttt ttctcctttt
     3781 gtttccggct ctccatcgcc ccggaaagcg cagccttatc cctggataag gattcattca
     3841 tttcgtttaa agatgtctgg gcagctttta atttctcatt ctgattctga atatccttat
     3901 caagatagcg aacctgatcc tgccacccgg agccatattc atgaggcggg ttataagtca
     3961 caaaatcatc tttatttgcc tctgcctctt ttaccttttt atcggcttcc tgaacagcag
     4021 cccttgcacc ggggatcgcc ttctctgtcg atgcaatgcg actgtttaag gtcgcaatat
     4081 ttttatcttc agcatccagc tcagctttcg ctttatcata ctctcttttc agcccctctt
     4141 ccgggtgagc agcgtcccat gcctgctggc gacgcttttc ttcctccaga cgctgtttta
     4201 cctgtgccgg agtaagaaca tccgtcaccg acacatagac cggtttctgt ccgctctctt
     4261 tcgggaaacg aataacggcc tcacgggagt taccaccggc cgtaaaacca gccggacgtg
     4321 aatcaccttt ttcagcaata atgccttttg gcggggcttt cgcggccgga acacctttag
     4381 gtacgctcac ctgcagagac gggagacccg gaatcgacac actgaatacc cccggacgtt
     4441 ttgtcggttt cgcatccacc acaggaacac tcattggccg gccggtgaca accgcaatat
     4501 gctgccgctc gtccttcaca atatccgcca cacgtttagt gacgctgacc gtcgcctggt
     4561 ccagcggcag ggagctgacc ggcgtctccg ttaccgtgtc tgccggcaat gacgtcacga
     4621 tttttgacat cattttcgga tcatcttttg ctatctcaga aggcagcact ccgtaaatcg
     4681 caatccccca cagaccaaac ttaaacggac ctttcagggc agccagcaca tcagcaacag
     4741 cggccgacaa cgcatcgccg gaaacggata aagccagtcc ttcagccccc ggagtggcca
     4801 gggcaggcag accgaaggcc atcgcggtgg ccgaagactg tccgccacca gagctcccgc
     4861 tatgattgcc gctgttaccg ccattaccac cgggtttact cccgccgtta ccaaactccc
     4921 ccgggttata gttatgaata tccccgttag gtgtatgcgt cgtaccccag cccggcccgc
     4981 tgtttggatc cgtaccacca cctgatgaag ggccaccttt acctgatgta ccgttcacat
     5041 tcccactggc ctgaccacca ttgtgtccca gacctgaatt acccggacct cgtccgtctc
     5101 cgccactcat atacttttcc tctttgactt ttaaaacaat aaactaaaat aaaatactgt
     5161 acatataacc actggtttta tatacagtac aaaaattacg ctgccttgtt tttcatgtca
     5221 agtctgtaaa tttgcgtttt tgtgaaaatg atcaaaaaaa cagccactca caccatgcgc
     5281 aatcccctcc agatgcaaca aaaaccagca caaacggcgc cgttctccgg cctcagtatg
     5341 ttttactgaa atcattatat gagataccag aaagccccct ccgggacagg aaaagaaacg
     5401 gggggtctgg ttcgggttgt tcggtcactg aacacggtca gaaactgatg ataagatagc
     5461 ctgcggatat ataactcaat gagaaaaaag aattaaaggt aaggagacgc tcatgagacg
     5521 ttccggcagc aaactgtgtc ttatcgccat gataacagcg acagcaactc tcactgcctg
     5581 tgctccaaag ggcagcgtgg aacagcatac ccggcattac gtatatgctt cagatgacgg
     5641 ttttgatccc aatttttcca cccagaaagc tgacacaaca cgaatgatgg tgcctttttt
     5701 ccggcagttc tgggatatgg gcgcaaagga taaagcgacc ggaaaatcac ggagtgatgt
     5761 gcagcaacgc attcagcagt ttcacagtca ggaattttta aactcactcc aaggcacaac
     5821 acaatttgcg ggtaccgatt accgcagcaa agacctcaca ccgaaaaaat caaggctact
     5881 ggctgacacc atttcagctg tttatctcga tggctatgaa ggcagacagt aagtggattt
     5941 accataacgc gtcattacgc gcaccgctca gacgggctca gggcgtttcc ggcggctacg
     6001 ggataaaaca ggcaacaacc cccccggaaa actgccggaa acgcgcccga taaattttat
     6061 cctaatgcat gcctatgcac gcaactgcat ggcatatgtt ttgacgtaaa atggatgccg
     6121 taagcccttt tttaccgact ttctgcttca tcagcctgac tgacacgacc atattctttc
     6181 agaccgcccc ctgctaaact tccttcatat tgccgcatta acccgggagg ctccgcaatg
     6241 agcaacacta cacactacga aaacgccaac tttcttcggg aactggctga aagcctgccc
     6301 cgcatactgc cggaaggtgg cccggacaaa gctgcgctgt tgcagcgact ggctaacgaa
     6361 gaactggccc aggcagagta tgaagatcag gttcgcgcca aagtgaccgc cgcccgtgct
     6421 gacacgcgtc cgggtatgac cacggaacaa ctccgccagc gcctgcatgg ccgttatcag
     6481 gaactgcgcg atgccgtatg acgtggaatg gaagcaggga gccatcgagg atgtaacgac
     6541 gctgtttgac tatatcgcgg aaaattcatc cctgtgggat gcgcagaacg ttaccgaccg
     6601 ggttctcgct gcggcggaca aactggccga cttcccgcga ctctatgaag tggactcacg
     6661 ctatggcgag gacgttcgcc ggatcagtct gatgggacag catgtcctct atgatgttga
     6721 tgaccagacc agaaaagtcc gggttctggc cgtggtcggc cagcgccaga atccccatat
     6781 tgttctctaa taaccggtga cggggacgca attcattgcg tggccgtcgc cggttggaca
     6841 agcacagcgc gtcagcgttt tccccacggc caccaccggc gcggtgttcc ggccggggtc
     6901 tctgctgtct ccggtttgtg ttccagcagt ctcatggact gcatttcctg ccgtagcccg
     6961 gccacctcct ccctgagtgc ttttatctcc gcgatcaacg cgtcggaggc cattttttca
     7021 gtctcacccg acagtctcaa ctcgtcccgc tcgtgagtct catcctgtct taactcaccg
     7081 tacacccgga taagctcgct ggtatccacc acccggccgc catcagcttc cgtacggtat
     7141 gatacgcggc ctttcgccat atcccgatac agggaacttc gggctttacc cgtcagttcc
     7201 gtcgcctgtc tcaccgtcac ccacgccatt gtctcacccc gctatttttg agacagtata
     7261 cctgacaggc gcacaccatg cccggaagga aagaatcatg acaaaacagg aaaaaacagc
     7321 cctcaatatg gctaaattta ttaaggagca gtcgctgcta ttgctcgata aactgaatga
     7381 gctggatatg gataccccgg ccgacatgtg cgagcggcta cacgaggatg cggaaacact
     7441 ctggcaggtg atgcgggata agctcgggga ggaataacag caccggcatg gccggtgctg
     7501 gcatttattt tttgccgaac ggccaccacc ggcgggcagg tttgtcctcc ggcagttcag
     7561 gtaccggcac gttaaaatag cggctgttat attcccgcat cagctccgct ttcagcttct
     7621 cgttcaccgc gctttccccg tgccgctcac tcaccacgtc aatcatcgcg ttaatctgct
     7681 ccggtgagca cttcccggca tcaaccacct gcacaccgtt ctcgatggcg aaccgctcca
     7741 ccttgcgata gaggtaatca cacagcttca ttcctgtggg tttgttccgt tcccattgcg
     7801 gatttttacc agtgaaaaag tacgtggctt tttcgtcgct gttgagccgc tcgtcataca
     7861 tcccgatgga tttcatcatc gccagatgct gggcccggtc gacaaaacag aaaacatacg
     7921 ccccggtctg ccaggcgagc accaccatat cttccagatg ctcgctggtc ggcatgatgc
     7981 agcgctcgcc gttccggtcc tccgcgtctt caataaatac catgtacagc gccataatcc
     8041 ctcactccgt tgtcataaat ttaaagcacg caaacaaccg ttcacgatcc agctctgccg
     8101 ttttgcgggc ctcgccggtc tgtgggttca cgatttcatc caccgacagg attgcccgct
     8161 gcaccctgac ctgcgtcgcc cggtccgggc agatgtacca gatttcatcg atgccgttag
     8221 ctttgcggtt gaacagatac ccggacacca cttcctgata ccggcgacgg ctcttgacgg
     8281 tgcgctccac ctcaaacgcc accgttttac cgtccagctc cgccagggcg tccggcactt
     8341 tcatgccttt aagactcaga cggtgcagaa tgcgccagcc ggtggcccct ctggcttcca
     8401 tatcaaggcg cagggattgc acggccagcc ggtgcggcag atgtgctgcc gacacccttg
     8461 acggctgaaa cggaataaca tccgccagcg gttcgtcctc gtcgaacgag aacgccacgc
     8521 catgcggcgt cagcccccac acgctgacct gacggccgtc caccggatat ttggtccgga
     8581 ccagcagccc tttcgccacc aggctgtcga ggaagcggta gaccggctgc accgccgcaa
     8641 tccccagccg ccgcgcaacc agctccgccg tggaacacag ctcttcccgc aaccagcgca
     8701 gggtcagccg ggttttctcc gcgttccgcg cctgtcgttt cgcgtggctg acgttgtaca
     8761 gctccagcgc catcagtaaa tccccgcaaa atcatcatcc gctttcggcc cgccgccgtc
     8821 ggccgggggc cggaactccg ccaggggatc ggttttcgcc agcaccggga aacgctgcaa
     8881 cgggatttcc cggcgctcaa cccgcagcgg actgctgaac gccatccggg ccacacccag
     8941 cccggtcatg accgcgaacc cgtccggcag gtgttgcagg gtgttcacgt caaacagcgg
     9001 ccgcgcctcc ttctggatga agctgtcccc gctgatatgc tccacgttcc ccgcctcccg
     9061 gctggcacgg cggcgctcca cgtccaccct gatttccccg gtctgccccg ccgcccactg
     9121 cgcggactcc aggctggccg cccggtaaaa ccagcggatc ggcgtgttat ccagtaccgt
     9181 ggttttcaca aattcagcgg gcagatcctg cccgcactgc ccgaaatcgc ccagcgactg
     9241 gtgcgcgagc aacagattgc agtcccggct gcgcagcgtc cccagtgcgt tcag
//
