LOCUS       NZ_CP082901             9294 bp    DNA     circular CON 10-JAN-2024
DEFINITION  Klebsiella aerogenes strain KAE3SP plasmid pKAE3SP-3, complete
            sequence.
ACCESSION   NZ_CP082901
VERSION     NZ_CP082901.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN20964956
            Assembly: GCF_019931695.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella aerogenes
  ORGANISM  Klebsiella aerogenes
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 9294)
  AUTHORS   Zhou,D.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-SEP-2021) State Key Laboratory of Pathogen and
            Biosecurity, Beijing Institute of Microbiology and Epidemiology,
            No.20, Dongdajie, Fengtai, Beijing, Beijing 100071, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. v 3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/10/2024 03:41:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,094
            CDSs (total)                      :: 4,973
            Genes (coding)                    :: 4,901
            CDSs (with protein)               :: 4,901
            Genes (RNA)                       :: 121
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 86
            ncRNAs                            :: 10
            Pseudo Genes (total)              :: 72
            CDSs (without protein)            :: 72
            Pseudo Genes (ambiguous residues) :: 0 of 72
            Pseudo Genes (frameshifted)       :: 32 of 72
            Pseudo Genes (incomplete)         :: 41 of 72
            Pseudo Genes (internal stop)      :: 11 of 72
            Pseudo Genes (multiple problems)  :: 10 of 72
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP082901.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..9294
                     /organism="Klebsiella aerogenes"
                     /mol_type="genomic DNA"
                     /strain="KAE3SP"
                     /host="Homo sapiens"
                     /db_xref="taxon:548"
                     /plasmid="pKAE3SP-3"
                     /collection_date="2012"
     gene            203..1888
                     /locus_tag="K6006_RS25400"
                     /old_locus_tag="K6006_25370"
     CDS             203..1888
                     /locus_tag="K6006_RS25400"
                     /old_locus_tag="K6006_25370"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin-like bacteriocin tRNase domain-containing
                     protein"
                     /protein_id="WP_004178188.1"
                     /translation="MSGGDGRGPGNSGLGHNGGQASGNVNGTSGKGGPSSGGGTDPNSG
                     PGWGTTHTPNGDIHNYNPGEFGNGGSKPGGNGGNSGNHSGSSGGGQSSATAMAFGLPAL
                     ATPGAEGLALSVSGDALSAAVADVLAALKGPFKFGLWGIAIYGVLPSEIAKDDPKMMSK
                     IVTSLPADTVTETPVSSLPLDQATVSVTKRVADIVKDERQHIAVVTGRPMSVPVVDAKP
                     TKRPGVFSVSIPGLPSLQVSVPKGVPAAKAPPKGIIAEKGDSRPAGFTAGGNSREAVIR
                     FPKESGQKPVYVSVTDVLTPAQVKQRLEEEKRRQQAWDAAHPEEGLKREYDKAKAELDA
                     EDKNIATLNSRIASTEKAIPGARAAVQEADKKVKEAEANKDDFVTYNPPHEYGSGWQDQ
                     VRYLDKDIQNQNEKLKAAQTSLNEMNESLSRDKAALSGAMESRKQKEKKAKDAENKLNE
                     EKKKPRKGTKDYGHDYFPDPKTEDIKGLGELKEGKPKTPKQGGGGKRARWYGDKKRKIY
                     EWDSQHGELEGYRASDGEHLGAFDPKTGKQVKGPDPKRNIKKYL"
                     /name="colicin-like bacteriocin tRNase domain-containing
                     protein"
     gene            1898..2155
                     /locus_tag="K6006_RS25405"
                     /old_locus_tag="K6006_25375"
     CDS             1898..2155
                     /locus_tag="K6006_RS25405"
                     /old_locus_tag="K6006_25375"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin immunity family protein"
                     /protein_id="WP_004152553.1"
                     /translation="MGLKLHIHWFDKKTEEFKGGEYSKDFGDDGSVIESLGMPLKDNIN
                     NGWFDVEKSWVSILQPHFKNVIDISKFDYFVSFVYRDGNW"
                     /name="cloacin immunity family protein"
     gene            2240..2389
                     /locus_tag="K6006_RS25410"
                     /old_locus_tag="K6006_25380"
     CDS             2240..2389
                     /locus_tag="K6006_RS25410"
                     /old_locus_tag="K6006_25380"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891188.1"
                     /GO_component="GO:0019867 - outer membrane [Evidence IEA]"
                     /GO_process="GO:0019835 - cytolysis [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin release lysis protein"
                     /protein_id="WP_004152552.1"
                     /translation="MKKVKVVFLFILIFSGFLLVACQANYIRDVQGGTVAPSSSSELTG
                     IAVQ"
                     /name="colicin release lysis protein"
     gene            3870..5834
                     /locus_tag="K6006_RS25415"
                     /old_locus_tag="K6006_25385"
     CDS             3870..5834
                     /locus_tag="K6006_RS25415"
                     /old_locus_tag="K6006_25385"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004178196.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TraM recognition domain-containing protein"
                     /protein_id="WP_004178196.1"
                     /translation="MFNTDSLAWKWHIPELARQIYPWVSWLYQEYYGLAGAFLVIGLFF
                     GLAELWAGRMRFVGLSHKERREYADRYKRDNKRPAPFSVLASLDSPGRMVRARRHVWNY
                     AYWLTGAAGLALLGGLVVAVFIESWGETVLRPDLYANADYYLLQPANLFGIAWCAGGLA
                     VGIVLARLLAFLLLDGHFAAADEAVNAKLNQESRRSSQRTGEMTDVRHLHFGEPVPVNA
                     LADFSSEQARQEQAVFLGKDEQGKPVLVPRDTWRKTNIQILGLPGSGKSVMATNALIRC
                     VRDFGDAVVYFDPKGDAWAPHVFRAHCPDFTLLDLRPGKPAQLNLFRDLDQYALKNLLI
                     AGLNLGETGDVADHYRISEQKAAKLIAEQFPQGANIQQVLAAAYALPEALKKDVKGLIT
                     RLENVADLSVLQTDSGIDVAGIINGGGCLYVIGSMDDEAVIRVQKMLFARCAQIIIARD
                     EFREWPHVSVMLDEIKYLLSKYVLNALGTLRSRDCNLLLAHQSLGDFGQCGQDLPAEFV
                     KTTVLDNTPIRWFYRAASLESAQWAAGQTGEIRVDVERRRASREAGNVEHISGDSFIQK
                     EARPLFDVNTLQHLPDGFAVMTGLGVARMAFSSPLRVERREIPLQRFPVLAKTDPLAEF
                     RPPADGGGPKADDDFAGIY"
                     /name="TraM recognition domain-containing protein"
     gene            5834..6565
                     /locus_tag="K6006_RS25420"
                     /old_locus_tag="K6006_25390"
     CDS             5834..6565
                     /locus_tag="K6006_RS25420"
                     /old_locus_tag="K6006_25390"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobC family replication-relaxation protein"
                     /protein_id="WP_004152551.1"
                     /translation="MALELYNVSHAKRQARNAEKTRLTLRWLREELCSTAELVARRLGI
                     AAVQPVYRFLDSLVAKGLLVRTKYPVDGRQVSVWGLTPHGVAFSFDEDEPLADVIPFQP
                     SRVSAAHLPHRLAVQSLRLDMEARGATGWRILHRLSLKGMKVPDALAELDGKTVAFEVE
                     RTVKSRRRYQEVVSGYLFNRKANGIDEIWYICPDRATQVRVQRAILSVDEIVNPQTGEA
                     RKTAELDRERLFACFKFMTTE"
                     /name="MobC family replication-relaxation protein"
     gene            6572..7102
                     /locus_tag="K6006_RS25425"
                     /old_locus_tag="K6006_25395"
     CDS             6572..7102
                     /locus_tag="K6006_RS25425"
                     /old_locus_tag="K6006_25395"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_004153058.1"
                     /translation="MALYMVFIEDAEDRNGERCIMPTSEHLEDMVVLAWQTGAYVFCFV
                     DRAQHLAMMKSIGMYDERLNSDEKATYFFTGKNPQWERNKPTGMKLCDYLYRKVERFAI
                     ENGVQVVDAGKCSPEQINAMIDVVSERHGESAVNEKLKAELMREYNSRYFNVPVPELPE
                     DKPARRWWPFGKK"
                     /name="hypothetical protein"
     gene            complement(7130..7309)
                     /locus_tag="K6006_RS25430"
                     /old_locus_tag="K6006_25400"
     CDS             complement(7130..7309)
                     /locus_tag="K6006_RS25430"
                     /old_locus_tag="K6006_25400"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rop family plasmid primer RNA-binding protein"
                     /protein_id="WP_000165971.1"
                     /translation="MTKQEKTALNMAKFIKEQSLLLLDKLNELDMDTPADMCERLHEDA
                     ETLWQVMRDKLGEE"
                     /name="Rop family plasmid primer RNA-binding protein"
     gene            7378..7755
                     /locus_tag="K6006_RS25435"
                     /old_locus_tag="K6006_25405"
     CDS             7378..7755
                     /locus_tag="K6006_RS25435"
                     /old_locus_tag="K6006_25405"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000312627.1"
                     /translation="MAWVTVRQATELTGKARSSLYRDMAKGRVSYRTEADGGRVVDTSE
                     LIRVYGELRQDETHERDELRLSGETEKMASDALIAEIKALREEVAGLRQEMQSMRLLEH
                     KPETAETPAGTPRRWWPWGKR"
                     /name="hypothetical protein"
     gene            complement(7817..8116)
                     /locus_tag="K6006_RS25440"
                     /old_locus_tag="K6006_25410"
     CDS             complement(7817..8116)
                     /locus_tag="K6006_RS25440"
                     /old_locus_tag="K6006_25410"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001146176.1"
                     /GO_function="GO:0008657 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) inhibitor activity
                     [Evidence IEA]; GO:0042803 - protein homodimerization
                     activity [Evidence IEA]"
                     /GO_process="GO:0030541 - plasmid partitioning [Evidence
                     IEA]; GO:0051290 - protein heterotetramerization [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_001146176.1"
                     /translation="MPYDVEWKQGAIEDVTTLFDYIAENSSLWDAQNVTDRVLAAADKL
                     ADFPRLYEVDSRYGEDVRRISLMGQHVLYDVDDQTRKVRVLAVVGQRQNPHIVL"
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            complement(8106..8369)
                     /locus_tag="K6006_RS25445"
                     /old_locus_tag="K6006_25415"
     CDS             complement(8106..8369)
                     /locus_tag="K6006_RS25445"
                     /old_locus_tag="K6006_25415"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000072676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000072676.1"
                     /translation="MSNTTHYENANFLRELAESLPRILPEGGPDKAALLQRLANEELAQ
                     AEYEDQVRAKVTAARADTRPGMTTEQLRQRLHGRYQELRDAV"
                     /name="hypothetical protein"
     gene            complement(8675..9094)
                     /locus_tag="K6006_RS25450"
                     /old_locus_tag="K6006_25420"
     CDS             complement(8675..9094)
                     /locus_tag="K6006_RS25450"
                     /old_locus_tag="K6006_25420"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016247941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Exc2 family lipoprotein"
                     /protein_id="WP_001254601.1"
                     /translation="MRRSGSKLCLIAMITATATLTACAPKGSVEQHTRHYVYASDDGFD
                     PNFSTQKADTTRMMVPFFRQFWDMGAKDKATGKSRSDVQQRIQQFHSQEFLNSLQGTTQ
                     FAGTDYRSKDLTPKKSRLLADTISAVYLDGYEGRQ"
                     /name="Exc2 family lipoprotein"
     BGC             1..6888
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          complement(2493..3071)
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="95.361"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          5835..6562
                     /name="MOBC"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="1.32e-150"
ORIGIN
        1 tgtgctggtt tttgttgcat ctggggggga ttgcgcatgg tgtgagtggc tgtttttttg
       61 atcattttca caaaaacgca aatttacaga cttgacatga aaaacaaggc agcgtaattt
      121 ttatactgta tataaaacca gtggttatat gtacagtatt ttattttagt ttattgtttt
      181 aaaagtcaaa gaggaaaagt atatgagtgg cggagacgga cgaggtccgg gtaattcagg
      241 tctgggacac aatggtggtc aggccagtgg gaatgtgaac ggtacatcag gtaaaggtgg
      301 cccttcatca ggtggtggta cggatccaaa cagcgggccg ggctggggta cgacgcatac
      361 acctaacggg gatattcata actataaccc gggggagttt ggtaacggcg ggagtaaacc
      421 cggtggtaat ggcggtaaca gcggcaatca tagcgggagc tctggtggcg gacagtcttc
      481 ggccaccgcg atggccttcg gtctgcctgc cttggccact ccgggggctg aaggactggc
      541 tttatccgtt tccggcgatg cgttgtcggc cgctgttgct gatgtgctgg ctgccctgaa
      601 aggtccgttt aagtttggtc tgtgggggat tgcgatttac ggagtgctgc cttctgagat
      661 agcaaaagat gatccgaaaa tgatgtcaaa aatcgtgacg tcattgccgg cagacacggt
      721 aacggagacg ccggtcagct ccctgccgct ggaccaggcg acggtcagcg tcactaaacg
      781 tgtggcggat attgtgaagg acgagcggca gcatattgcg gttgtcaccg gccggccaat
      841 gagtgttcct gtggtggatg cgaaaccgac aaaacgtccg ggggtattca gtgtgtcgat
      901 tccgggtctc ccgtctctgc aggtgagcgt acctaaaggt gttccggccg cgaaagcccc
      961 gccaaaaggc attattgctg aaaaaggtga ttcacgtccg gctggtttta cggccggtgg
     1021 taactcccgt gaagccgtta ttcgtttccc gaaagagagc ggacagaaac cggtctatgt
     1081 gtcggtgacg gatgttctta ctccggcaca ggtaaaacag cgtctggagg aagaaaagcg
     1141 tcgccagcag gcatgggacg ctgctcaccc ggaagagggg ctgaaaagag agtatgataa
     1201 agcgaaagct gagctggatg ctgaagataa aaatattgcg accttaaaca gtcgcattgc
     1261 atcgacagag aaggcgatcc ccggtgcaag ggctgctgtt caggaagccg ataaaaaggt
     1321 aaaagaggca gaggcaaata aagatgattt tgtgacttat aacccgcctc atgaatatgg
     1381 ctccgggtgg caggatcagg ttcgctatct tgataaggat attcagaatc agaatgagaa
     1441 attaaaagct gcccagacat ctttaaacga aatgaatgaa tccttatcca gggataaggc
     1501 tgcgctttcc ggggcgatgg agagccggaa acaaaaggag aaaaaagcga aggatgcaga
     1561 aaataaatta aatgaggaaa agaaaaaacc tcgtaaggga actaaagatt acggccatga
     1621 ttattttcct gatcccaaga ctgaagatat taaggggttg ggagagttga aagagggtaa
     1681 acctaaaacc cctaaacaag gtggtggtgg taagcgggcc cgatggtatg gtgataaaaa
     1741 gcgtaaaatt tatgaatggg attcccagca cggtgagctt gaagggtacc gcgccagtga
     1801 tggcgaacac ctcggggcat tcgatccaaa aacgggtaag caggttaaag ggccggatcc
     1861 aaaacgaaac attaaaaaat atctttaaga ggtaaatatg gggcttaaat tacatattca
     1921 ttggtttgat aagaaaaccg aagagtttaa aggtggtgaa tactcaaaag acttcggtga
     1981 tgatggttct gtcattgaaa gtctggggat gcctttaaag gataatatta ataatggttg
     2041 gtttgatgtt gaaaaatcat gggtttcgat attacagcca cactttaaaa atgtaatcga
     2101 tattagtaaa tttgattact ttgtatcctt tgtttaccgg gatggtaact ggtaagcaaa
     2161 agttatcaag gatgatttga aatacagact tccggtgttc agggatgaat accggggttt
     2221 ttaaatacag ggaaggtata tgaaaaaggt aaaggttgtt tttcttttta tattgatttt
     2281 ttcaggcttt cttctggtcg catgtcaggc aaactatatc cgggatgttc agggtggaac
     2341 ggtggcacca tcgtcctcct ctgaactgac ggggatcgcg gttcagtaga aaagatcaaa
     2401 ggatcttctt gagatccttt ttttctgcgc gtaatctttt gccctgtaaa cgaaaaaacc
     2461 acctggggag gtggtttgat cgaaggttaa gtcagttggg gaactgctta accgtggtaa
     2521 ctggctttcg cagagcacag caaccaaatc tgtccttcca gtgtagccgg actttggcgc
     2581 acacttcaag agcaaccgcg tgtttagcta aacaaatcct ctgcgaactc ccagttacca
     2641 atggctgctg ccagtggcgt tttgcgtgct tttccgggtt ggactcaagt gaacagttac
     2701 cggataaggc gcagcagtcg ggctgaacgg ggggttcttg cttacagccc agcttggagc
     2761 gaacgaccta caccgagccg agataccaga gtgtgagcta tgagaaagcg ccacacttcc
     2821 cgcaagggag aaaggcggaa caggtatccg ggaaacggca gggttggaac aggagagcgc
     2881 aagagggagc gattcatcgg aaacggtgat gatctttaag tcctgtcggg tttcgccact
     2941 cctgactgat tcatggttga gccaccggct cccacagatg caccgaaaaa gcgtctgttt
     3001 atgtgaactc agtcaggagg gcggagccta tggaaaaacg ccacctgcgt ggccttgccg
     3061 ttttgcctca catgttagtc ccctgcttat tcacggaatc tgtgggtaac tttgcatgtg
     3121 tccgcagcgc ccgccgcagt ctcacggccg gagcgtagcg accgagtgag cgaggaggcg
     3181 caatttcccc ggcacctaca agacggacac cggacgcgct gatgtggcat attgtcccct
     3241 gattaagtct ttatattccc tgataataaa ttaccaggat aggtgaatca tatcggtttt
     3301 tcgctgaaca ttttacgtta acctatctct gttgcttttt tctccttacg gagaaataca
     3361 ggtcatcccc gcgagggcgt ggctgacctc agggggatat cccctgctta cgctggctgg
     3421 acgccaccga cgcacggtct ctccccctct ttctggctcc gtccggctgg acgccggcca
     3481 cgccagaaat tcacccggcc cccgtcaggc tcacgcctga ccacccacaa aaatccacgg
     3541 tgctggacgc acctggcgaa gcagcaaagc tgctcctgat tttgcgggtg gtcagccgct
     3601 cgctatggcg aactctgacg ggggccggaa caccggaaaa gaccgcactg gggtgccgcc
     3661 ttttcctctc acacgctggg gcgtgctcgt tgttcctccg gggctgcgcc ttttccgcat
     3721 ggggcggaaa gaggctggcc tccgtggtga aagctgaacg caatcaccac ggacgtgacc
     3781 gccgccgcca tgccttgggg catgtccgcg gcttgtgcag cgggggctgc acatcacgcc
     3841 ggcaaaccat cgtctgaagg agagagaaca tgtttaatac ggattcgctt gcctggaagt
     3901 ggcacattcc ggagctggcc cggcagattt atccgtgggt cagctggctg taccaggagt
     3961 attacggtct ggccggggct ttcctagtta tcggcctgtt tttcggtctg gctgaacttt
     4021 gggccggacg gatgcgtttt gtggggctga gtcataagga gcgacgggag tatgccgatc
     4081 gctataagcg cgataataaa cggccagcgc cattttcggt gctggcctcg ctggattcgc
     4141 ccgggcggat ggtcagggca cgtcgacatg tctggaacta cgcgtactgg ctgaccggcg
     4201 cggccggtct ggcccttctg ggggggctgg ttgtcgccgt gtttatcgag agctggggag
     4261 aaaccgtcct gcgtccggac ctctacgcaa acgcagatta ttacctgctg cagccggcta
     4321 acctgttcgg gattgcctgg tgcgcgggcg ggctggctgt cgggattgtg ttggcgcggc
     4381 tgctggcgtt cctgctgctt gacggtcatt ttgcggctgc tgacgaggcg gtgaacgcga
     4441 aactgaatca ggagagccgg cgcagcagcc agcggacagg agagatgacc gacgtgcgcc
     4501 acctgcattt cggggagccg gtaccggtta atgcgctggc cgatttttcc tcggagcagg
     4561 cccggcagga gcaggcggtg tttctgggta aggatgagca gggcaagccg gtgctggttc
     4621 cgcgtgatac ctggcgcaag accaacattc agatcctcgg cctgcccggg agcggcaaga
     4681 gcgtgatggc caccaacgcg ctcattcgct gcgtacgcga tttcggggac gcggtggtgt
     4741 acttcgaccc caaaggggac gcatgggcgc cgcacgtctt ccgggcgcac tgtccggact
     4801 tcaccctgct ggatctgcgg ccggggaaac cggcgcagct gaatctgttc cgcgatctcg
     4861 accagtacgc gctgaaaaac ctgctgattg ccgggcttaa cctgggcgag accggcgacg
     4921 tggcggacca ctaccgcatc agcgagcaga aagcggcgaa gctgattgcg gagcagtttc
     4981 cgcagggggc aaacattcag caggtgctgg cggcggcgta cgcgctgccg gaggccctga
     5041 aaaaggacgt gaaggggttg atcactaggc tggaaaacgt cgctgacctg agcgtcctgc
     5101 agacggacag tggcatcgat gtggcgggga ttatcaacgg cggcggctgc ctgtacgtta
     5161 tcggctcgat ggacgacgag gcggtgatcc gtgtgcaaaa aatgctgttt gcccgctgcg
     5221 cgcaaatcat cattgcgcgg gacgagttcc gggagtggcc acacgtcagc gtgatgctcg
     5281 atgaaattaa atatctgctg tcgaagtatg tactgaacgc actggggacg ctgcgcagcc
     5341 gggactgcaa tctgttgctc gcgcaccagt cgctgggcga tttcgggcag tgcgggcagg
     5401 atctgcccgc tgaatttgtg aaaaccacgg tactggataa cacgccgatc cgctggtttt
     5461 accgggcggc cagcctggag tccgcgcagt gggcggcggg gcagaccggg gaaatcaggg
     5521 tggacgtgga gcgccgccgt gccagccggg aggcggggaa cgtggagcat atcagcgggg
     5581 acagcttcat ccagaaggag gcgcggccgc tgtttgacgt gaacaccctg caacacctgc
     5641 cggacgggtt cgcggtcatg accgggctgg gtgtggcccg gatggcgttc agcagtccgc
     5701 tgcgggttga gcgccgggaa atcccgttgc agcgtttccc ggtgctggcg aaaaccgatc
     5761 ccctggcgga gttccggccc ccggccgacg gcggcgggcc gaaagcggat gatgattttg
     5821 cggggattta ctgatggcgc tggagctgta caacgtcagc cacgcgaaac gacaggcgcg
     5881 gaacgcggag aaaacccggc tgaccctgcg ctggttgcgg gaagagctgt gttccacggc
     5941 ggagctggtt gcgcggcggc tggggattgc ggcggtgcag ccggtctacc gcttcctcga
     6001 cagcctggtg gcgaaagggc tgctggtccg gaccaaatat ccggtggacg gccgtcaggt
     6061 cagcgtgtgg gggctgacgc cgcatggcgt ggcgttctcg ttcgacgagg acgaaccgct
     6121 ggcggatgtt attccgtttc agccgtcaag ggtgtcggca gcacatctgc cgcaccggct
     6181 ggccgtgcaa tccctgcgcc ttgatatgga agccagaggg gccaccggct ggcgcattct
     6241 gcaccgtctg agtcttaaag gcatgaaagt gccggacgcc ctggcggagc tggacggtaa
     6301 aacggtggcg tttgaggtgg agcgcaccgt caagagccgt cgccggtatc aggaagtggt
     6361 gtccgggtat ctgttcaacc gcaaagctaa cggcatcgat gaaatctggt acatctgccc
     6421 ggaccgggcg acgcaggtca gggtgcagcg ggcaatcctg tcggtggatg aaatcgtgaa
     6481 cccacagacc ggcgaggccc gcaaaacggc agagctggat cgtgaacggt tgtttgcgtg
     6541 ctttaaattt atgacaacgg agtgagggat tatggcgctg tacatggtat ttattgaaga
     6601 cgcggaggac cggaacggcg agcgctgcat catgccgacc agcgagcatc tggaagatat
     6661 ggtggtgctc gcctggcaga ccggggcgta tgttttctgt tttgtcgacc gggcccagca
     6721 tctggcgatg atgaaatcca tcgggatgta tgacgagcgg ctcaacagcg acgaaaaagc
     6781 cacgtacttt ttcactggta aaaatccgca atgggaacgg aacaaaccca caggaatgaa
     6841 gctgtgtgat tacctctatc gcaaggtgga gcggttcgcc atcgagaacg gtgtgcaggt
     6901 ggttgatgcc gggaagtgct caccggagca gattaacgcg atgattgacg tggtgagtga
     6961 gcggcacggg gaaagcgcgg tgaacgagaa gctgaaagcg gagctgatgc gggaatataa
     7021 cagccgctat tttaacgtgc cggtacctga actgccggag gacaaacctg cccgccggtg
     7081 gtggccgttc ggcaaaaaat aaatgccagc accggccatg ccggtgctgt tattcctccc
     7141 cgagcttatc ccgcatcacc tgccagagtg tttccgcatc ctcgtgtagc cgctcgcaca
     7201 tgtcggccgg ggtatccata tccagctcat tcagtttatc gagcaatagc agcgactgct
     7261 ccttaataaa tttagccata ttgagggctg ttttttcctg ttttgtcatg attctttcct
     7321 tccgggcatg gtgtgcgcct gtcaggtata ctgtctcaaa aatagcgggg tgagacaatg
     7381 gcgtgggtga cggtgagaca ggcgacggaa ctgacgggta aagcccgaag ttccctgtat
     7441 cgggatatgg cgaaaggccg cgtatcatac cgtacggaag ctgatggcgg ccgggtggtg
     7501 gataccagcg agcttatccg ggtgtacggt gagttaagac aggatgagac tcacgagcgg
     7561 gacgagttga gactgtcggg tgagactgaa aaaatggcct ccgacgcgtt gatcgcggag
     7621 ataaaagcac tcagggagga ggtggccggg ctacggcagg aaatgcagtc catgagactg
     7681 ctggaacaca aaccggagac agcagagacc ccggccggaa caccgcgccg gtggtggccg
     7741 tggggaaaac gctgacgcgc tgtgcttgtc caaccggcga cggccacgca atgaattgcg
     7801 tccccgtcac cggttattag agaacaatat ggggattctg gcgctggccg accacggcca
     7861 gaacccggac ttttctggtc tggtcatcaa catcatagag gacatgctgt cccatcagac
     7921 tgatccggcg aacgtcctcg ccatagcgtg agtccacttc atagagtcgc gggaagtcgg
     7981 ccagtttgtc cgccgcagcg agaacccggt cggtaacgtt ctgcgcatcc cacagggatg
     8041 aattttccgc gatatagtca aacagcgtcg ttacatcctc gatggctccc tgcttccatt
     8101 ccacgtcata cggcatcgcg cagttcctga taacggccat gcaggcgctg gcggagttgt
     8161 tccgtggtca tacccggacg cgtgtcagca cgggcggcgg tcactttggc gcgaacctga
     8221 tcttcatact ctgcctgggc cagttcttcg ttagccagtc gctgcaacag cgcagctttg
     8281 tccgggccac cttccggcag tatgcggggc aggctttcag ccagttcccg aagaaagttg
     8341 gcgttttcgt agtgtgtagt gttgctcatt gcggagcctc ccgggttaat gcggcaatat
     8401 gaaggaagtt tagcaggggg cggtctgaaa gaatatggtc gtgtcagtca ggctgatgaa
     8461 gcagaaagtc ggtaaaaaag ggcttacggc atccatttta cgtcaaaaca tatgccatgc
     8521 agttgcgtgc ataggcatgc attaggataa aatttatcgg gcgcgtttcc ggcagttttc
     8581 cgggggggtt gttgcctgtt ttatcccgta gccgccggaa acgccctgag cccgtctgag
     8641 cggtgcgcgt aatgacgcgt tatggtaaat ccacttactg tctgccttca tagccatcga
     8701 gataaacagc tgaaatggtg tcagccagta gccttgattt tttcggtgtg aggtctttgc
     8761 tgcggtaatc ggtacccgca aattgtgttg tgccttggag tgagtttaaa aattcctgac
     8821 tgtgaaactg ctgaatgcgt tgctgcacat cactccgtga ttttccggtc gctttatcct
     8881 ttgcgcccat atcccagaac tgccggaaaa aaggcaccat cattcgtgtt gtgtcagctt
     8941 tctgggtgga aaaattggga tcaaaaccgt catctgaagc atatacgtaa tgccgggtat
     9001 gctgttccac gctgcccttt ggagcacagg cagtgagagt tgctgtcgct gttatcatgg
     9061 cgataagaca cagtttgctg ccggaacgtc tcatgagcgt ctccttacct ttaattcttt
     9121 tttctcattg agttatatat ccgcaggcta tcttatcatc agtttctgac cgtgttcagt
     9181 gaccgaacaa cccgaaccag accccccgtt tcttttcctg tcccggaggg ggctttctgg
     9241 tatctcatat aatgatttca gtaaaacata ctgaggccgg agaacggcgc cgtt
//
