LOCUS       NZ_CP082011            10049 bp    DNA     circular CON 10-JAN-2024
DEFINITION  Klebsiella pneumoniae strain KP18-41 plasmid pKP18-41-2, complete
            sequence.
ACCESSION   NZ_CP082011
VERSION     NZ_CP082011.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN20928631
            Assembly: GCF_019823805.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 10049)
  AUTHORS   Qin,S. and Dong,H.
  TITLE     Klebsiella pneumoniae KP18-41
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10049)
  AUTHORS   Qin,S. and Dong,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-AUG-2021) Institute of Drug Discovery & Development,
            Zhengzhou University, 100 Science Avenue, Zhengzhou City, Zhengzhou,
            Henan 450001, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: unicycler v. v.0.4.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 12.0x
            Sequencing Technology             :: Illumina; Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/10/2024 03:31:36
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,816
            CDSs (total)                      :: 5,694
            Genes (coding)                    :: 5,534
            CDSs (with protein)               :: 5,534
            Genes (RNA)                       :: 122
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 86
            ncRNAs                            :: 11
            Pseudo Genes (total)              :: 160
            CDSs (without protein)            :: 160
            Pseudo Genes (ambiguous residues) :: 0 of 160
            Pseudo Genes (frameshifted)       :: 59 of 160
            Pseudo Genes (incomplete)         :: 108 of 160
            Pseudo Genes (internal stop)      :: 15 of 160
            Pseudo Genes (multiple problems)  :: 22 of 160
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP082011.1.
            Bacteria and source DNA available from Patient.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..10049
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="KP18-41"
                     /isolation_source="blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:573"
                     /plasmid="pKP18-41-2"
                     /geo_loc_name="China"
                     /lat_lon="34.73 N 113.70 E"
                     /collection_date="2018-06-21"
                     /collected_by="Zhengzhou University"
     gene            join(9998..10049,1..377)
                     /locus_tag="K6147_RS27820"
     CDS             join(9998..10049,1..377)
                     /locus_tag="K6147_RS27820"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001140599.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001140599.1"
                     /translation="MAKTLLNLSQAAQAAGITRRTLYNHVKQGKVTVSRDGKNNPVVDV
                     SELIRVYGNVNIPEKQIPGISHRENTQKNFPQEQLLAMQKELADLRQAVTLMLEDKTSR
                     EEERRQHDDERRKLQAEVDRLTTELTQKKKRFWSGWFS"
                     /name="hypothetical protein"
     gene            403..582
                     /locus_tag="K6147_RS27825"
     CDS             403..582
                     /locus_tag="K6147_RS27825"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rop family plasmid primer RNA-binding protein"
                     /protein_id="WP_000165970.1"
                     /translation="MTKQEKTALNMAKFIKDQSLLLLEKLNELDMDTPADMCERLHEDA
                     ETLWQVMRDKLGEE"
                     /name="Rop family plasmid primer RNA-binding protein"
     gene            complement(609..1139)
                     /locus_tag="K6147_RS27830"
     CDS             complement(609..1139)
                     /locus_tag="K6147_RS27830"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_071177729.1"
                     /translation="MALYMVFIEDVEDKDGERCIMPTSEHLEDMVVLAWQTGAYVFCFV
                     DRAQHLAMMKSIGMYDERLNSDEKATYFFTGENPQWERDKPTGMKLCDYLYRKVERFAI
                     ENGVQVVDAGKCSPEQINAMIEVVSERHGESAVNEKLKAELMREYNSRYFNVPVPELPE
                     DKPARRWWPFGKK"
                     /name="hypothetical protein"
     gene            complement(1146..1877)
                     /gene="mobC"
                     /locus_tag="K6147_RS27835"
     CDS             complement(1146..1877)
                     /gene="mobC"
                     /locus_tag="K6147_RS27835"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobC family replication-relaxation protein"
                     /protein_id="WP_071177728.1"
                     /translation="MTLEQYNVSHAKRQARNAEKTRLTLRWLREELCSTAELVARRLGI
                     AAVQPVYRFLDSLVAKGLLVRAKYPVDGRQVSVWGLTPHGVAFSFDEDEPLTDVIPFQP
                     SRVSAAQLPHRLAVQSLRLSMEGRGATGWRYLHRMALKGMKVPDALAELDGRTVAFEVE
                     RTVKSRRRYQEVVSGYLFNRRANGIDEIWYICPDRPTLVRVQRAILAVDEIVNPQTGEA
                     RKTVELDRERLFACFKFMTTE"
                     /name="mobC"
     gene            complement(1877..3841)
                     /locus_tag="K6147_RS27840"
     CDS             complement(1877..3841)
                     /locus_tag="K6147_RS27840"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004178196.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TraM recognition domain-containing protein"
                     /protein_id="WP_071177727.1"
                     /translation="MFNTDSLAWQWHIPELARQIYPWVSWLYREYYSLAGFFLVIGLFF
                     GLAELWAGRMRFVGLSHKARREYADRYKRDNNRTVPFSVLASLDSPGRMVRARRHVWNY
                     AYWLTGAAGLALLGGLVVAVFIESWGETVLRPDLYANADYYLLQPANLFGIAWCAGGLV
                     AGVLLARLLAFLLLDGHFAAADEAVNAKLNQESRRSSQRTGEMTDVRHLHFGEPVPVNA
                     LADFSTEQARKQQAVFLGKDEQGQPVLVPRDTWRKTNIQILGLPGSGKSAMATNALIRC
                     VRDFGDAVVYFDPKGDAWAPHVFRAHCPDFTLLDLRPGKPAQLNLFRDLDQYALKNLLV
                     AGFNLSETGDVADHYRISEQKAAKLIAEQFPQGANIQQVLAAAYALPEALKKDVKGLIT
                     KLENVADLSVLQTDSGIDVAGIINGGGCLYVIGSMDDEAVIRVQKMLFARCAQIIIARD
                     EFRRWPHASIMLDEIKYLLSKYVLNALGTLRSRDCNLLLAHQSLGDFGQCGQDLPADFV
                     KTTVLDNTPIRWFYRAASQESAQWAAGQTGEIRVDVERRRASREAGNVEHISGDSFIQK
                     EARPLFDVNTLQHLPDGFAVMTGLGVARLAFSSPLRVERREISLKTFPVLAKTDPLAEY
                     LPPADGGGPKADDDFAGLY"
                     /name="TraM recognition domain-containing protein"
     gene            4973..5131
                     /locus_tag="K6147_RS29325"
     CDS             4973..5131
                     /locus_tag="K6147_RS29325"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005761324.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /protein_id="WP_071596352.1"
                     /translation="MHEPPVQPDCCALSGNYHLESNPDGHAKTPLAAAIGNWIYTREIL
                     RGLEVGA"
                     /name="replication initiation protein"
     gene            complement(5314..5463)
                     /locus_tag="K6147_RS27845"
     CDS             complement(5314..5463)
                     /locus_tag="K6147_RS27845"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891188.1"
                     /GO_component="GO:0019867 - outer membrane [Evidence IEA]"
                     /GO_process="GO:0019835 - cytolysis [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin release lysis protein"
                     /protein_id="WP_032440454.1"
                     /translation="MKKVKTIFLFILIVAGFLLAACQANYIRDVQGGTVAPSSSSELTG
                     IAVQ"
                     /name="colicin release lysis protein"
     gene            complement(5548..5805)
                     /locus_tag="K6147_RS27850"
     CDS             complement(5548..5805)
                     /locus_tag="K6147_RS27850"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891189.1"
                     /GO_function="GO:0015643 - toxic substance binding
                     [Evidence IEA]"
                     /GO_process="GO:0030153 - bacteriocin immunity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin E3-like toxin immunity protein"
                     /protein_id="WP_032440455.1"
                     /translation="MGLKLRLTWFDKKTEEFKGEEYSKDFGDDGSVIESLGMPLKDNIN
                     NGEFDLKKEWVPLLQPFFKNQIKPDVDNCYIAFDYRDGNW"
                     /name="colicin E3-like toxin immunity protein"
     gene            complement(5815..7500)
                     /locus_tag="K6147_RS27855"
     CDS             complement(5815..7500)
                     /locus_tag="K6147_RS27855"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin-like bacteriocin tRNase domain-containing
                     protein"
                     /protein_id="WP_032440457.1"
                     /translation="MSGGDGRGPGNSGLGHNGGQASGNVNGTSGKGGPSSGGGTDPNSG
                     PGWGTTHTPNGDIHNYNPGEFGNGGSKPGGNGGNSGNHSGSSGGGQSSATAMAFGLPAL
                     ATPGAEGLALSVSGDALSAAVADVLAALKGPFKFGLWGIAIYGVLPSEIAKDDPKMMSK
                     IMTSLPADAVTETPASTLPLDQATVRVRQRVVDVVKDERQHIAVVAGRPMSVPVVDAKP
                     TKRPGVFSVSIPGLPSLQVSVPKGVPTAKAPPKGIVAEKGDSRPAGFTAGGNSREAVIR
                     FPKETGQKPVYVSVTDVLTPAQVKQRQEEEKRRQQAWDAAHPEEGLKRDYDKAKAELDA
                     EDKNIATLNSRIASTEKALPGARAAVQEADKKVKEAEANKDDFVTYNPPHEYGSGWQDQ
                     VRYLDKDIQNQNEKLKAAQASLNAMNESLSRDKAALTGAMESRKQKEKKAKDAENKLNE
                     EKNKPRKGTKDYGHDYHPVPKTEDIKGLGELKRGDPKTPKQGGGGKRARWYGDKKRKIY
                     EWDSQHGELEGYRASDGEHLGAFDPKTGKQVKGPDPKRNIKKYL"
                     /name="colicin-like bacteriocin tRNase domain-containing
                     protein"
     gene            7827..8072
                     /locus_tag="K6147_RS27860"
     CDS             7827..8072
                     /locus_tag="K6147_RS27860"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146442.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_032440458.1"
                     /translation="MTHLKLTPAEEKRLADAFVAQALAMGLKGNKTLPKAVKQQVRERV
                     LRAIQDEREARRAQEMRREKYEATETTFTWQPQRRR"
                     /name="hypothetical protein"
     gene            8346..8717
                     /gene="tolA"
                     /locus_tag="K6147_RS27865"
     CDS             8346..8717
                     /gene="tolA"
                     /locus_tag="K6147_RS27865"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001237044.1"
                     /GO_component="GO:0098567 - periplasmic side of plasma
                     membrane [Evidence IEA]"
                     /GO_function="GO:0005215 - transporter activity [Evidence
                     IEA]"
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell envelope integrity protein TolA"
                     /protein_id="WP_001237044.1"
                     /translation="MRLIPFILLALCSPLLLTACKHSTTQPPKIYTLDKSSKISSYAAA
                     IKTAVEMQMFEPEAYAGKMCTVRISIQRDGTLNSAIAEGGDPKLCKAAISAVTHAKIPP
                     APDENTWQIFKNAPLDFRP"
                     /name="tolA"
     gene            8714..9079
                     /locus_tag="K6147_RS29065"
     CDS             8714..9079
                     /locus_tag="K6147_RS29065"
                     /inference="COORDINATES: protein motif:HMM:TIGR01352.1"
                     /GO_function="GO:0015291 - secondary active transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TonB family protein"
                     /protein_id="WP_072354022.1"
                     /translation="MKAFTLTVLAAMFLTPVHAIPLKPVTTLQPTYPVQAAAKRIEGQV
                     TATFDILDDGRVDNVSLTGCHLFFRETLTAMRHWLYPAGHPAMRQVINFEFSLKNDGLQ
                     DPRPVTTQKLNDDGCRQ"
                     /name="TonB family protein"
     gene            9254..9532
                     /locus_tag="K6147_RS27875"
     CDS             9254..9532
                     /locus_tag="K6147_RS27875"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014542884.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CopG family ribbon-helix-helix protein"
                     /protein_id="WP_000093040.1"
                     /translation="MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEK
                     RSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWGTENEQDAPPCHR"
                     /name="CopG family ribbon-helix-helix protein"
     gene            9520..9834
                     /locus_tag="K6147_RS27880"
     CDS             9520..9834
                     /locus_tag="K6147_RS27880"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001136729.1"
                     /GO_function="GO:0008657 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) inhibitor activity
                     [Evidence IEA]; GO:0042803 - protein homodimerization
                     activity [Evidence IEA]"
                     /GO_process="GO:0030541 - plasmid partitioning [Evidence
                     IEA]; GO:0051290 - protein heterotetramerization [Evidence
                     IEA]; GO:0009432 - SOS response [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_071177730.1"
                     /translation="MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKT
                     LPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDREMDQIVIVTVRHQKESGYPGADSL
                     "
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     BGC             815..10049
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          4644..5211
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="88.795"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(1150..1877)
                     /name="MOBC"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="93.416"
                     /coverage="100.0"
                     /evalue="1.34e-140"
ORIGIN
        1 ccagaagaac gctatacaat catgtaaaac agggaaaggt taccgtgtca cgtgacggga
       61 aaaacaaccc tgtcgtggat gtgtcagaac tgatccgtgt atacggaaat gtgaatatcc
      121 ctgagaaaca aattcccggc atttcacacc gtgaaaatac acaaaaaaat ttcccacagg
      181 aacagcttct ggcaatgcaa aaggaactgg ccgatctccg gcaggctgtc accctgatgc
      241 tggaagataa aacatcccgg gaagaagaac gccgccagca cgatgatgag cgccggaaac
      301 tccaggccga agtggacaga ttgacaacag aactgacaca gaagaaaaaa cgcttctggt
      361 ccggctggtt tagctgagaa cttaccgaag ggaatggaga acatgacgaa gcaggaaaaa
      421 actgccctca atatggctaa attcattaag gatcagtcgc tgctgttgct ggaaaagctg
      481 aacgagctgg acatggatac cccggccgac atgtgcgaac ggcttcacga ggatgcggaa
      541 acactctggc aggtgatgcg ggataagctc ggggaagaat aacagcaccg gccatgccgg
      601 tgctggcgtt attttttgcc gaacggccac caccggcggg cgggtttgtc ctccggcagt
      661 tcaggcaccg gcacgttaaa atagcggctg ttatattccc gcatcagctc cgctttcagc
      721 ttctcgttca ccgcgctttc cccgtgccgc tcgctgacca cctcaatcat cgcgttaatc
      781 tgctccggtg agcacttccc ggcatcaacc acctgcacac cgttctcgat ggcgaaccgc
      841 tccacctttc gatagaggta atcacacagc ttcattcctg tgggtttgtc ccgttcccat
      901 tgcggatttt caccggtgaa aaagtacgtg gctttttcgt cgctgttgag ccgctcgtca
      961 tacatcccga tggatttcat catcgccaga tgctgggccc ggtcgacaaa acagaaaaca
     1021 tacgccccgg tctgccaggc gagcaccacc atgtcttcca gatgctcgct ggttggcata
     1081 atgcagcgct cgccgtcttt gtcttccacg tcctcaataa ataccatgta cagcgccata
     1141 atccctcact ccgttgtcat aaatttaaag cacgcgaaca gcctctcccg gtccagctcc
     1201 accgttttgc gggcctcgcc ggtctgtgga ttcacgattt catccaccgc cagaatcgcc
     1261 cgctgtaccc ggacaagcgt cggccggtca gggcagatgt accagatttc atcgatgccg
     1321 ttcgcccggc ggttgaacag atacccggac accacttcct gataccgcct gcggctcttg
     1381 acggtgcgct ctacctcaaa tgccaccgtt ctgccgtcca gctccgccag cgcgtccggc
     1441 actttcatcc ctttcagggc catacggtgc aggtaccgcc agccggtggc cccccggccc
     1501 tccatggaga ggcgcaggga ctgcacggcc agccggtgcg gcagctgcgc cgccgacacc
     1561 cttgacggct gaaacggaat aacgtccgtc agcggctcgt cctcgtcgaa cgagaacgcc
     1621 accccgtgcg gcgtcagccc ccacacgctg acctgacggc cgtcaaccgg gtatttcgcc
     1681 cggaccagca gccctttcgc caccagactg tccaggaagc ggtaaaccgg ctgtaccgcc
     1741 gcaatcccca gccgtcgcgc aaccagctcc gccgtggaac acagctcttc ccgcagccag
     1801 cgcagggtca gccgtgtttt ctccgcgttc cgcgcctgcc gcttcgcgtg gctgacgttg
     1861 tactgctcca gtgtcatcag taaagccccg caaaatcatc atccgctttt ggtccgccgc
     1921 cgtcggccgg aggcaggtac tccgccagcg ggtccgtttt cgccagcacc gggaaggttt
     1981 tcagcgaaat ttcccggcgc tcaacccgca gcgggctgct gaacgccagc cgcgccacgc
     2041 ccagcccggt catcaccgcg aacccgtcag gcaggtgttg cagggtgttc acgtcaaaca
     2101 gcggccgcgc ctccttctgg atgaagctgt cgccgctgat gtgctccacg ttccccgcct
     2161 cccggctggc ccggcggcgc tccacgtcca cccggatctc cccggtctgg cccgccgccc
     2221 actgcgcgga ctcctggctg gccgcgcgat agaaccagcg gatcggcgtg ttatccagta
     2281 ccgtggtttt cacaaaatca gcgggcagat cctgcccgca ctgaccgaag tcgcccagcg
     2341 actggtgcgc gagcagcagg ttgcagtccc ggctgcgcag cgtccccagc gcgttcagca
     2401 cgtacttcga cagcagatat ttaatctcat cgagcatgat gctcgcgtgc ggccacctcc
     2461 ggaactcatc ccgcgcaatg atgatttgcg cgcagcgggc aaacagcatc ttctgcaccc
     2521 ggatcaccgc ctcatcgtcc atcgagccga tgacgtacag gcagccgccg ccgttgatta
     2581 tccccgccac atcgataccg ctgtccgtct gcaggacgct caggtcggcc acgttctcca
     2641 gcttggtgat cagccccttc acgtcctttt tcagggcctc cggcaacgcg tacgccgccg
     2701 ccagcacctg ctgaatgttt gccccctgcg ggaactgctc cgcaatcagc ttcgccgctt
     2761 tctgctcgct gatgcggtag tggtccgcca cgtcgccggt ctcactcagg ttaaacccgg
     2821 caaccagcag attcttcagg gcgtactggt cgagatcgcg gaacagattc agctgcgccg
     2881 gtttccccgg ccgcagatcc agcagggtga agtccgggca gtgcgcccgg aagacgtgcg
     2941 gcgcccacgc gtcccctttg gggtcgaagt acaccacagc gtccccgaaa tcgcgtacgc
     3001 agcgaatgag cgcgttggtg gccatcgcgc tcttgccgct cccgggcagg ccgaggatct
     3061 gaatattggt cttgcgccag gtatcacgag ggaccagcac cggctggccc tgctcatcct
     3121 tacccagaaa caccgcctgc tgtttccggg cctgctccgt ggaaaaatcg gccagcgcgt
     3181 taaccggtac cggctccccg aaatgcaggt ggcggacgtc tgtcatttct ccggtccgct
     3241 ggctgctgcg ccggctctcc tgattcagtt tcgcgttcac cgcctcgtca gcggccgcaa
     3301 aatgaccatc aagcagcagg aacgccagca gccgcgccag aaggacgccg gcgacaagcc
     3361 ctccggcaca ccaggctatc ccgaacaggt tagccggctg cagcaggtaa taatctgcgt
     3421 tcgcatagag gtccgggcgc aggacggttt ctccccagct ctcgataaac acggcgacaa
     3481 ccagcccccc cagaagggcc agaccggcag cgccggtcag ccagtacgcg tagttccaga
     3541 catgtcgccg tgccctgacc atccgcccgg gtgaatccag cgaggccagc accgaaaatg
     3601 gcacagtccg gttattatcg cgcttatagc gatcggcata ctcccgccgc gccttatggc
     3661 tcagccccac aaaacgcatt cggccggccc agagttcagc cagaccgaaa aacaggccga
     3721 taaccagaaa aaaaccggcc agactgtaat actcccggta cagccagctg acccacgggt
     3781 aaatctgccg ggccagctcc gggatatgcc actgccaggc aagcgaatcc gtattaaaca
     3841 tgcaatctct ctccttcaga cgacgggttt accggcgtga tgcgcagccc ccgctgcaca
     3901 agccgcggac atgccccaag gcatggcggc ggcggtcacg tccgtggtga ttgcgttcag
     3961 ctttcaccgc ggaggccagc ctctttccgc cccatgcgga aaaggcgcag ccccggagga
     4021 acaacgagca cgccccagcg tgtgagagga aaaggcggca ccccagtgcg gtcttttccg
     4081 gtgttccggc ccccgtcaga gttcgccata gcgagcggct gaccacccgc aaaatcagga
     4141 gcagctttgc tgcttcgtca ggtgcgtcca gcaccgtgga tttttgtggg tggtcaggcg
     4201 tgagcctgac gggggccggg tgaatttctg gcgtggccgg cgtccagccg gacagagcca
     4261 gaaagagggg aaaagaccgt gcgtcggtgg cgtccagcca gcgtaagcaa ggtcttttcc
     4321 cctgaagtca gccacgcccc agcggggatg acttgcattt ctccgcaagg agaaaaaagc
     4381 aacagagata ggttaacgta aaatgttcag cgaaaaaccg acatggttca cctatcctga
     4441 taattgatcg tcagggaata gaaagactta atcaggggac aatatcccac atcagcgcgt
     4501 ccggtgaccg tcttgcaggt gccggggaaa ttgcgcctcc tcgctcactc ggtcgctacg
     4561 ctccgggcgt gagactgcgg cgggcgctgc ggacacatac aaagttaccc acagattccg
     4621 tggataagca ggggactaac atgtgaggca aaacggcagg gccgcgccgg tggcgttttt
     4681 ccataggctc cgccctcctg ccagagttca cataaacaga cgctttttcg gtgcatctgt
     4741 gggagccgtg aggctcaacc atgaatctga cagtacgggc gaaacccgac aggacttaaa
     4801 gatccccacc gtttccggta ggtcgctccc tcttgcgctc tcctgttccg accctgccgt
     4861 ttaccggata cctgttccgc ctttttccct ttcgggaagc gtggcgcttt ctcatagctc
     4921 acgctgctgg tatctcggct cggtttaggt cgttcgctcc aagctgggct gtatgcacga
     4981 accccccgtt cagcccgact gctgcgccct ttccggtaac tatcatcttg agtccaaccc
     5041 ggacggacac gcaaaaacgc cactggcagc agccattggt aactggatat atacgagaga
     5101 gatattgaga ggtcttgaag tgggtgccta actgcggcta cactgaaaga acagttttgg
     5161 tatctgcggt ctcgtatacc cagttacccg gttaagcagt tccccaactg acttaacctt
     5221 cgatcaaacc gcctccccag gcggtttttt cgtttacagt gcaagagatt acgcgcagaa
     5281 aaaaaggatc tcaagaagat cctttgatct tttctactga accgcgatcc ccgtcagttc
     5341 agaggaggac gatggtgcca ccgttccgcc ctgaacatcc cggatataat ttgcctgaca
     5401 tgcggccaga agaaagccag caacaatcaa tataaaaaga aaaatagtct ttaccttttt
     5461 catatacttt ccctgtattt aaagactccg gcattcatcc ctgaacaccg gaagtcagta
     5521 tttcaaatca tccttgataa ttttttgtta ccagttaccg tcccgataat caaaagctat
     5581 ataacaatta tccacatcag gttttatttg atttttaaaa aatggctgta gtaaaggaac
     5641 ccattctttc ttcaaatcaa actcaccatt attaatatta tcctttaaag gcattcccaa
     5701 gctttcaatg acagaaccat cgtcaccaaa gtctttagaa tactcttccc ctttaaactc
     5761 ttcagttttc ttatcaaacc atgtcaaacg taatttaagc cccatattta cctctcaaag
     5821 atatttttta atgttccgtt ttggatctgg ccctttaacc tgcttacccg ttttgggatc
     5881 aaatgcgcct aggtgttcgc catcactggc acgataccct tcaagctcac cgtgctggga
     5941 atcccattca taaattttac gttttttatc gccataccat cgggcccgct taccaccacc
     6001 accttgttta ggtgttttag gatcacctcg ctttaactct ccaagtccct ttatgtcttc
     6061 tgttttaggt actggatgat aatcatggcc gtagtcttta gtccccttgc gaggcttgtt
     6121 cttttcctca tttaacttat tttctgcatc cttcgctttt ttctcctttt gtttccggct
     6181 ctccatcgcc ccggtaagtg cagccttatc tctggataag gattcattca ttgcgtttaa
     6241 agatgcctga gccgctttta atttctcatt ctgattctga atatccttat caagatagcg
     6301 aacctgatcc tgccacccgg agccatattc atgaggcggg ttataagtca caaaatcatc
     6361 tttatttgcc tctgcctctt ttaccttttt atcggcttcc tgaacagcag cccttgcacc
     6421 ggggagcgcc ttctctgtcg atgcaatgcg gctgtttaag gtcgcaatat ttttatcttc
     6481 ggcatccagc tcagctttcg ctttatcata gtctcttttc agcccctctt ccggatgagc
     6541 ggcgtcccat gcctgctggc gacgcttttc ttcctcctga cgctgtttta cctgtgccgg
     6601 ggtaagaaca tctgtcaccg acacataaac cggcttctgt ccggtctctt tcgggaaacg
     6661 aataacggcc tcacgggagt taccaccggc tgtaaaacca gccggacgtg aatcaccttt
     6721 ttcagcaaca atgccttttg gcggggcttt cgctgtcgga acacctttcg gtacgctcac
     6781 ctgcagagac gggagacccg gaatcgacac actgaatacc cccggacgtt ttgtcggttt
     6841 cgcatccacc acagggacac tcattggccg acctgcgaca accgcaatat gctgccgctc
     6901 atccttcacc acatccacaa cccgttgtct gacacgaacc gtcgcctggt ccagtggtaa
     6961 agtacttgcc ggagtctccg tcaccgcatc ggccggtaat gacgtcataa tttttgacat
     7021 cattttcgga tcatcttttg caatctcaga aggcagcaca ccgtagatcg caatccccca
     7081 cagaccaaac ttaaacggcc ccttcagggc agccagcaca tcagcaacgg cggccgacaa
     7141 cgcatcgccg gaaactgata aagccagtcc ttcagccccc ggagtagcca gggcaggcag
     7201 accgaaggcc atcgcagtgg ccgaagactg tccgccacca gagctaccgc tatgattgcc
     7261 gctgttacca ccattaccac cgggtttact cccgccgtta ccaaactccc ccggattata
     7321 gttatgaata tctccattcg gcgtatgcgt cgtaccccag cccggcccgc tgtttggatc
     7381 cgtaccacca cctgatgaag ggccaccttt accagacgta ccgttcacat tcccactggc
     7441 ctgaccacca ttatgtccca gacctgaatt acccggacct cgaccgtctc caccactcat
     7501 accgttttcc tctttgacat ttaaaacaat aaattaaagc caacatactg tacatataca
     7561 cagtataatt attaccttac tcctcccgtt ttcaggtgtc aatatatgag attagttctc
     7621 atcttcaggc acaaaaaagc gcccggagcc acctgtaagc agatcgcgtc ttttcccgaa
     7681 aatttctcat ggcaacaaat tttattattt aagacattca tcacacttac atttcagatg
     7741 gtatagacac atctgaaagc taactggcat gaggagagga cctgcggtta aactgttcgg
     7801 gaaacctgag acgcccggag gccactatga cgcacctgaa actgactccc gctgaagaaa
     7861 agcgcctggc ggacgccttt gtcgctcagg cactggccat gggcctgaaa gggaacaaaa
     7921 cgctgccaaa ggcggtaaaa caacaggtgc gggaaagggt gcttcgtgcc attcaggacg
     7981 aacgtgaagc caggcgggcg caggaaatgc gtcgggagaa atacgaggct acggaaacca
     8041 ccttcacctg gcagccacag cgccgccggt aaggggtatt taccataacg tcgcattgcc
     8101 cgcaccgctc agacggtctg agggcgtttc cggcggctac gggataaaac aggcaacaaa
     8161 ccacccggaa aaccgccgga aacgcgcccg gtaaattgta acccgctgca tgcctatgca
     8221 cgcaactgca tggcgggccg tttggtgtaa aaacgatacg ataagccgtg tttatgtaaa
     8281 tgaacgtggc cgtaaagagt gacaaatata catgtaacat tttttactga caggtcatca
     8341 acccgatgcg tttaataccc tttatcctgc tggcattgtg cagcccctta ctcctgacgg
     8401 cctgtaagca ttccaccacc cagccgccga aaatttatac tctggataag tcatctaaaa
     8461 tcagtagcta cgctgcggcc atcaagaccg ctgttgaaat gcagatgttt gaaccagagg
     8521 cctatgcggg aaaaatgtgc accgtgcgga tatccataca acgtgatggc actctgaaca
     8581 gcgccattgc tgaaggagga gatccgaaac tctgtaaagc agcaatatca gccgttaccc
     8641 acgccaaaat tccgccggca ccggatgaaa atacctggca aatattcaaa aacgcccctc
     8701 tggatttcag accatgaaag cttttactct gacagtgctg gcggccatgt tcctcactcc
     8761 ggtacatgcg ataccactaa aacccgtaac cacactgcag ccaacctacc cggtacaggc
     8821 cgcagcaaaa cgcatcgaag gtcaggtgac cgccacgttt gatattctgg acgatggacg
     8881 agtggacaac gtgtcgctta ccggctgtca cctttttttt cgggaaacgc tgacggcaat
     8941 gaggcactgg ctatatcccg cagggcaccc ggcaatgcga caggttataa attttgaatt
     9001 cagtctgaaa aatgacggct tacaggatcc gcgaccagtc accacccaaa agctcaatga
     9061 tgatggttgc cgccagtaac aggtccttta acccgcaggc tgcaatagtc ctggatgatg
     9121 agtgagcctg tagcagccct gattagtgga agcgaagctg aaaaatgggc agcaaaagcc
     9181 gtatttctgg caaatagcgc cgccacggat taaagtagtc atgtgtaata catatgacta
     9241 caaaggggct tttatgtcat cagcaacatc catcaggctc gatgaagaac ttaaggaccg
     9301 gctgaaaacg ctggccgatg accggcaccg ctcagcgcac gcgctaatgc tggaggcaat
     9361 caccgaatac atcgaccggg aagagaagcg cagccagtac ctgcgggacg gacaggccgc
     9421 atggcagcac tatcaggaaa cgggtctgca ccttactgcg gaagaagcgg aagcctggat
     9481 aagtacctgg ggaactgaga acgagcagga tgctccgcca tgccacaggt aacgatttcc
     9541 gcgctggcac agcgcgattt acaacgcctt caggactttc tcaaaaccaa aaatcggctg
     9601 gcagccagaa aaggaggtga ggtgatcgtc cgggctatcc agcaactgaa aacattgcca
     9661 gacattggcc gcccggtgcc gtttctgccg ctggaatata aggaactggt gatcgggttt
     9721 ggcgacagtg gctatgtgat gctctaccgc cacgaccggg aaatggacca gattgtgatc
     9781 gtcaccgtca ggcatcagaa agaatccggg tatccggggg cagacagcct ctaataaccg
     9841 atgacggggg cgcaattcat tgcgtggccg tcgccggttt gacaagcgca gcgcgtcaga
     9901 aaaccacatc ctgaacggaa aaacgggtaa aattcagcga tacatttacc gtgagaaatt
     9961 acacaccttt cacacccgat aaaatcaggg gtatacagtg gcgaaaacat tgctcaacct
    10021 ttcacaggca gcacaagccg cgggcatta
//
