LOCUS       NZ_CP073794             8801 bp    DNA     circular CON 10-JAN-2024
DEFINITION  Klebsiella pneumoniae isolate KP_NORM_BLD_2010_71621 plasmid
            unnamed_3, complete sequence.
ACCESSION   NZ_CP073794
VERSION     NZ_CP073794.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMEA8602826
            Assembly: GCF_019798185.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 8801)
  AUTHORS   Fostervold,A., Hetland,M.A.K., Samuelsen,O., Sundsfjord,A.,
            Simonsen,G.S., Bernhoff,E., Bakksjo,R., Wyres,K.L., Holt,K.E. and
            Lohr,I.H.
  TITLE     A nationwide genomic study of clinical Klebsiella pneumoniae
            isolates in Norway 2001-2015
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8801)
  AUTHORS   Fostervold,A., Hetland,M.A.K., Samuelsen,O., Sundsfjord,A.,
            Simonsen,G.S., Bernhoff,E., Bakksjo,R., Wyres,K.L., Holt,K.E. and
            Lohr,I.H.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-APR-2021) Department of Medical Microbiology,
            Stavanger University Hospital, Gerd Ragna Bloch Thorsens gate 8,
            Stavanger 4011, Norway
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 58x
            Sequencing Technology             :: Illumina MiSeq; Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/10/2024 03:34:47
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,516
            CDSs (total)                      :: 5,396
            Genes (coding)                    :: 5,271
            CDSs (with protein)               :: 5,271
            Genes (RNA)                       :: 120
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 86
            ncRNAs                            :: 9
            Pseudo Genes (total)              :: 125
            CDSs (without protein)            :: 125
            Pseudo Genes (ambiguous residues) :: 0 of 125
            Pseudo Genes (frameshifted)       :: 54 of 125
            Pseudo Genes (incomplete)         :: 81 of 125
            Pseudo Genes (internal stop)      :: 32 of 125
            Pseudo Genes (multiple problems)  :: 33 of 125
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP073794.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..8801
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
                     /isolate="KP_NORM_BLD_2010_71621"
                     /isolation_source="Blood"
                     /host="Homo sapiens"
                     /db_xref="taxon:573"
                     /plasmid="unnamed_3"
                     /geo_loc_name="Norway"
                     /collection_date="2010"
     gene            complement(join(7453..8801,1..613))
                     /locus_tag="KFO61_RS27355"
                     /old_locus_tag="KFO61_27355"
     CDS             complement(join(7453..8801,1..613))
                     /locus_tag="KFO61_RS27355"
                     /old_locus_tag="KFO61_27355"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004178196.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TraM recognition domain-containing protein"
                     /protein_id="WP_032448356.1"
                     /translation="MFNTDSLAWQWHIPELARQIYPWVSWLYREYYSLAGFFLVIGLFF
                     GLAELWAGRMRFVGLSHKERREYADRYKRDNNRTAPFSVLASLDSPGRMVRARRHVWNY
                     AYWLTGAAGLALLGGLVVAVFIESWGETVLRPDLYANADYYLLQPANLFGIAWCAGGLV
                     AGVLLARLLAFLLLDGHFAAADEAVNAKLNQESRRSSQRTGEMTDVRHLHFGEPVPVNA
                     LADFSTEQARKQQAVFLGKDEQGQPVLVPRDTWRKTNIQILGLPGSGKSVMATNALIRC
                     VRDFGDAVVYFDPKGDAWAPHVFRAHCPDFTLLDLRPGKPAQLNLFRDLDQYALKNLLV
                     AGFNLSETGDVADHYRISEQKAAKLIAEQFPQGANIQQVLAAAYALPEALKKDVKGLIT
                     KLENVADLSVLQTDSGIDVAGIINGGGCLYVIGSMDDEAVIRVQKMLFARCAQIIIARD
                     EFRRWPHASIMLDEIKYLLSKYVLNALGTLRSRDCNLLLAHQSLGDFGQCGQDLPADFV
                     KTTVLDNTPIRWFYRAASQESAQWAAGQTGEIRVDVERRRASREAGNVEHISGDSFIQK
                     EARPLFDVNTLQHLPDGFAVMTGLGVARLAFSSPLRVDRREIPLKTFPVLAKTDPLAEY
                     QSEAGRQRPGDDDFAGLY"
                     /name="TraM recognition domain-containing protein"
     gene            complement(2096..2245)
                     /locus_tag="KFO61_RS27360"
                     /old_locus_tag="KFO61_27360"
     CDS             complement(2096..2245)
                     /locus_tag="KFO61_RS27360"
                     /old_locus_tag="KFO61_27360"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891188.1"
                     /GO_component="GO:0019867 - outer membrane [Evidence IEA]"
                     /GO_process="GO:0019835 - cytolysis [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin release lysis protein"
                     /protein_id="WP_032440454.1"
                     /translation="MKKVKTIFLFILIVAGFLLAACQANYIRDVQGGTVAPSSSSELTG
                     IAVQ"
                     /name="colicin release lysis protein"
     gene            complement(2330..2587)
                     /locus_tag="KFO61_RS27365"
                     /old_locus_tag="KFO61_27365"
     CDS             complement(2330..2587)
                     /locus_tag="KFO61_RS27365"
                     /old_locus_tag="KFO61_27365"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891189.1"
                     /GO_function="GO:0015643 - toxic substance binding
                     [Evidence IEA]"
                     /GO_process="GO:0030153 - bacteriocin immunity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin E3-like toxin immunity protein"
                     /protein_id="WP_032440455.1"
                     /translation="MGLKLRLTWFDKKTEEFKGEEYSKDFGDDGSVIESLGMPLKDNIN
                     NGEFDLKKEWVPLLQPFFKNQIKPDVDNCYIAFDYRDGNW"
                     /name="colicin E3-like toxin immunity protein"
     gene            complement(2597..4282)
                     /locus_tag="KFO61_RS27370"
                     /old_locus_tag="KFO61_27370"
     CDS             complement(2597..4282)
                     /locus_tag="KFO61_RS27370"
                     /old_locus_tag="KFO61_27370"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin-like bacteriocin tRNase domain-containing
                     protein"
                     /protein_id="WP_094313770.1"
                     /translation="MSGGDGRGPGNSGLGHNGGQASGNVNGTSGKGGPSSGGGTDPNSG
                     PGWGTTHTPNGDIHNYNPGEFGNGGSKPGGNGGNSGNHSGSSGGGQSSATAMAFGLPAL
                     ATPGAEGLALSVSGDALSAAVADVLAALKGPFKFGLWGIAIYGVLPSEIAKDDPKMMSK
                     IMTSLPADAVTETPASTLPLDQATVRVRQRVVDVVKDERQHIAVVAGRPMSVPVVDAKP
                     TKRPGVFSVSIPGLPSLQVSVPKGVPTAKAPPKGIVAEKGDSRPAGFTAGGNSREAVIR
                     FPKETGQKPVYVSVTDVLTPAQVKQRQEEEKRRQQAWDAAHPEEGLKRDYDKAKAELDA
                     EDKNIATLNSRIASTEKALPGARAAVQEADKKVKEAEANKDDFVTYNPPHEYGSGWQDQ
                     VRYLDKDIQNQNEKLKAAQASLNVMNESLSRDKAALTGAMESRKQKEKKAKDAENKLNE
                     EKNKPRKGTKDYGHDYHPVPKTEDIKGLGELKRGDPKTPKQGGGGKRARWYGDKKRKIY
                     EWDSQHGELEGYRASDGEHLGAFDPKTGKQVKGPDPKRNIKKYL"
                     /name="colicin-like bacteriocin tRNase domain-containing
                     protein"
     gene            4609..4854
                     /locus_tag="KFO61_RS27375"
                     /old_locus_tag="KFO61_27375"
     CDS             4609..4854
                     /locus_tag="KFO61_RS27375"
                     /old_locus_tag="KFO61_27375"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146442.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_032440458.1"
                     /translation="MTHLKLTPAEEKRLADAFVAQALAMGLKGNKTLPKAVKQQVRERV
                     LRAIQDEREARRAQEMRREKYEATETTFTWQPQRRR"
                     /name="hypothetical protein"
     gene            5160..5423
                     /locus_tag="KFO61_RS27380"
                     /old_locus_tag="KFO61_27380"
     CDS             5160..5423
                     /locus_tag="KFO61_RS27380"
                     /old_locus_tag="KFO61_27380"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000072676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid stabilization protein"
                     /protein_id="WP_094313764.1"
                     /translation="MSNTTHYENANFLRELAENLPRILPESGPDKAALLQCLANEELAQ
                     AEYEDQVRAKVTAARADTRPGMTTEQLRQRLHGRYQELRDAV"
                     /name="plasmid stabilization protein"
     gene            5413..5712
                     /locus_tag="KFO61_RS27385"
                     /old_locus_tag="KFO61_27385"
     CDS             5413..5712
                     /locus_tag="KFO61_RS27385"
                     /old_locus_tag="KFO61_27385"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009365129.1"
                     /GO_function="GO:0008657 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) inhibitor activity
                     [Evidence IEA]; GO:0042803 - protein homodimerization
                     activity [Evidence IEA]"
                     /GO_process="GO:0030541 - plasmid partitioning [Evidence
                     IEA]; GO:0051290 - protein heterotetramerization [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_094313765.1"
                     /translation="MPYEVEWKQGAIEDVTTLFDYIAENSSLWDAQNVTDRVLTAADKL
                     ADFPRLYEVDSRYGEDVRRISLMGQHVLYDVDDQTRKVRVLAVVGQRQNPHTVR"
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            complement(5774..6151)
                     /locus_tag="KFO61_RS27390"
                     /old_locus_tag="KFO61_27390"
     CDS             complement(5774..6151)
                     /locus_tag="KFO61_RS27390"
                     /old_locus_tag="KFO61_27390"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="entry exclusion protein 1"
                     /protein_id="WP_094313766.1"
                     /translation="MAWVTVRQATELTGKARSSLYRDMAKGRVSYRTEADGGRVMDTSE
                     LIRVYGELRQGETHERDGLRLPDETEKTAFDALIAEIKALREEVAGLRQEMQAMRLLEH
                     KPETAETPAGTPRRWWQWGKR"
                     /name="entry exclusion protein 1"
     gene            6220..6399
                     /locus_tag="KFO61_RS27395"
                     /old_locus_tag="KFO61_27395"
     CDS             6220..6399
                     /locus_tag="KFO61_RS27395"
                     /old_locus_tag="KFO61_27395"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rop family plasmid primer RNA-binding protein"
                     /protein_id="WP_094313767.1"
                     /translation="MTKQEKTALNMAKFIKDQSLLLLEKLNELDMDTPADMCERLHEDA
                     EKLWLAMRDHLGEE"
                     /name="Rop family plasmid primer RNA-binding protein"
     gene            complement(6430..6693)
                     /locus_tag="KFO61_RS27400"
                     /old_locus_tag="KFO61_27400"
     CDS             complement(6430..6693)
                     /locus_tag="KFO61_RS27400"
                     /old_locus_tag="KFO61_27400"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_094313768.1"
                     /translation="MTNRVVAVGREALLMVAVMAGTLVVLAGNLLKLLWRVLPVLLLLY
                     GVVQFLARNPEIRDWLFLHFGQGGTAAILVGGILLCMRRLMK"
                     /name="hypothetical protein"
     gene            complement(6722..7453)
                     /gene="mobC"
                     /locus_tag="KFO61_RS27405"
                     /old_locus_tag="KFO61_27405"
     CDS             complement(6722..7453)
                     /gene="mobC"
                     /locus_tag="KFO61_RS27405"
                     /old_locus_tag="KFO61_27405"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobC family replication-relaxation protein"
                     /protein_id="WP_094313769.1"
                     /translation="MALERYNVSHAKRQARNAEKTRLTLRWLREELCSTAELVAQRLGI
                     AAVQPVYRFLDSLVAKGLLVRAKYPVDGRQVSVWGLTPHGVAFSFDEDEPLTDIIPFQP
                     SRVSAAQLPHRLAVQSLRLAMEARGATGWRYLHRIALKGMKVPDALAELDGRTVAFEVE
                     RTVKSRRRYQEVVSGYLFNRRANGIDEIWYICPDRATQVRVQRAILAVDEIVNPQTGEA
                     RKTVELDRERLFACFKFMMMD"
                     /name="mobC"
     BGC             1..8801
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          1415..1993
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="98.282"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(6726..7453)
                     /name="MOBC"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="93.004"
                     /coverage="100.0"
                     /evalue="1.97e-140"
ORIGIN
        1 ctccggtccg ctggctgctg cgccggctct cctgattcag tttcgcgttc accgcctcgt
       61 cagcggccgc aaaatgcccg tcaagcagca ggaacgccag cagccgcgcc aggaggacgc
      121 ctgcgacaag acctccggca caccaggcaa tcccgaacag gttagccggc tgcagcaggt
      181 aataatctgc gttcgcgtag aggtccggac gcaggacggt ttctccccag ctctcgataa
      241 acacggcgac aaccagcccc cccagaaggg ccagaccggc agcgccggtc agccagtatg
      301 cgtagttcca gacatgtcgc cgtgccctga ccatccgccc gggcgaatcc agcgaggcca
      361 gcaccgaaaa tggcgcagtc cggttattat cgcgcttata gcgatcggca tactcccggc
      421 gctccttatg actcagcccc acgaatcgca tccgcccggc ccagagttct gccagaccga
      481 aaaacaggcc gataaccaga aaaaaaccgg ccagactgta atactcccgg tacagccagc
      541 tgacccacgg gtaaatctgc cgggccagct ccgggatatg ccactgccag gcaagcgaat
      601 ccgtattaaa catgcaatct ctctccttca gacgacgggt ttaccggcgt gatgcgcagc
      661 ccccgctgca caagccgcgg acatgcccca aggcatggcg gcggcggtca cgtccgtggt
      721 gattgcgttc agctttcacc gcggaggcca gcctctttcc gccccatgcg gaaaaggcgc
      781 agccccggag gaacaacgag cacgccccag cgtgtgagag gaaaaggcgg caccccagtg
      841 cggtcttttc cggtgttccg gcccccgtca gagttcgcca tagcgagcgg ctgaccaccc
      901 gcaaaatcag gagcagcttt gctgcttcgt caggtgcgtc cagcaccgtg gattttgtgg
      961 gtggtcaggc gtgagcctga cgggggccgg gtgaatttct ggcgtggccg gcgtccagcc
     1021 ggacagagcc agaaagaggg gaaaagaccg tgcgtcggtg gcgtccagcc agcgtaagca
     1081 aggtcttttc ccctgaagtc agccacgccc cagcggggat gacttgcatt tctccgcaag
     1141 gagaaaaaag caacagagat aggttaacgt aaaatgttca gcgaaaaacc gacatggttc
     1201 acctatcctg ataattgatc gtcagggaat agaaagactt aatcagggga caatatccca
     1261 catcagcgcg tccggtgacc gtcttgcagg tgccggggaa attgcgcctc ctcgctcact
     1321 cggtcgctac gctccgggcg tgagactgcg gcgggcgctg cggacacata caaagttacc
     1381 cacagattcc gtggataagc aggggactaa catgtgaggc aaaacggcag ggccgcgccg
     1441 gtggcgtttt tccataggct ccgccctcct gccagagttc acataaacag acgctttttc
     1501 ggtgcatctg tgggagccgt gaggctcaac catgaatctg acagtacggg cgaaacccga
     1561 caggacttaa agatccccac cgtttccggt aggtcgctcc ctcttgcgct ctcctgttcc
     1621 gaccctgccg tttaccggat acctgtccgc cgttctccct tgcgggaagt gtggcgcttt
     1681 ctcatagctc acacactggt atctcggctc ggtgtaggtc gttcgctcca agctgggctg
     1741 taagcaagaa ctccccgttc agcccgactg ctgcgcctta tccggtaact gttcacttga
     1801 gtccaacccg ggaaagcacg caaaacgcca ctggcagcag ccattggtaa ctgggagttc
     1861 gcagaggatt tgtttagcta aacacgcggt tgctcttgaa gtgtgcgcca aagtccggct
     1921 acactggaag gacagatttg gttgctgtgc tctgcgaaag ccagttacca cggttaagca
     1981 gttccccaac tgacttaacc ttcgatcaaa ccacctcccc aggtggtttt ttcgtttaca
     2041 gggcaaaaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat cttttctact
     2101 gaaccgcgat ccccgtcagt tcagaggagg acgatggtgc caccgttccg ccctgaacat
     2161 cccggatata atttgcctga catgcggcca gaagaaagcc agcaacaatc aatataaaaa
     2221 gaaaaatagt ctttaccttt ttcatatact ttccctgtat ttaaagactc cggcattcat
     2281 ccctgaacac cggaagtcag tatttcaaat catccttgat aattttttgt taccagttac
     2341 cgtcccgata atcaaaagct atataacaat tatccacatc aggttttatt tgatttttaa
     2401 aaaatggctg tagtaaagga acccattctt tcttcaaatc aaactcacca ttattaatat
     2461 tatcctttaa aggcattccc aagctttcaa tgacagaacc atcgtcacca aagtctttag
     2521 aatactcttc ccctttaaac tcttcagttt tcttatcaaa ccatgtcaaa cgtaatttaa
     2581 gccccatatt tacctctcaa agatattttt taatgttccg ttttggatct ggccctttaa
     2641 cctgcttacc cgttttggga tcaaatgcgc ctaggtgttc gccatcactg gcacgatacc
     2701 cttcaagctc accgtgctgg gaatcccatt cataaatttt acgtttttta tcgccatacc
     2761 atcgggcccg cttaccacca ccaccttgtt taggtgtttt aggatcacct cgctttaact
     2821 ctccaagtcc ctttatgtct tctgttttag gtactggatg ataatcatgg ccgtagtctt
     2881 tagtcccctt gcgaggcttg ttcttttcct catttaactt attttctgca tccttcgctt
     2941 ttttctcctt ttgtttccgg ctctccatcg ccccggtaag tgcagcctta tctctggata
     3001 aggattcatt cattacgttt aaagatgcct gagccgcttt taatttctca ttctgattct
     3061 gaatatcctt atcaagatag cgaacctgat cctgccaccc ggagccatat tcatgaggcg
     3121 ggttataagt cacaaaatca tctttatttg cctctgcctc ttttaccttt ttatcggctt
     3181 cctgaacagc agcccttgca ccggggagcg ccttctctgt cgatgcaatg cggctgttta
     3241 aggtcgcaat atttttatct tcggcatcca gctcagcttt cgctttatca tagtctcttt
     3301 tcagcccctc ttccggatga gcggcgtccc atgcctgctg gcgacgcttt tcttcctcct
     3361 gacgctgttt tacctgtgcc ggggtaagaa catctgtcac cgacacataa accggcttct
     3421 gtccggtctc tttcgggaaa cgaataacgg cctcacggga gttaccaccg gctgtaaaac
     3481 cagccggacg tgaatcacct ttttcagcaa caatgccttt tggcggggct ttcgctgtcg
     3541 gaacaccttt cggtacgctc acctgcagag acgggagacc cggaatcgac acactgaata
     3601 cccccggacg ttttgtcggt ttcgcatcca ccacagggac actcattggc cgacctgcga
     3661 caaccgcaat atgctgccgc tcatccttca ccacatccac aacccgttgt ctgacacgaa
     3721 ccgtcgcctg gtccagtggt aaagtacttg ccggagtctc cgtcaccgca tcggccggta
     3781 atgacgtcat aatttttgac atcattttcg gatcatcttt tgcaatctca gaaggcagca
     3841 caccgtagat cgcaatcccc cacagaccaa acttaaacgg ccccttcagg gcagccagca
     3901 catcagcaac ggcggccgac aacgcatcgc cggaaactga taaagccagt ccttcagccc
     3961 ccggagtagc cagggcaggc agaccgaagg ccatcgcagt ggccgaagac tgtccgccac
     4021 cagagctacc gctatgattg ccgctgttac caccattacc accgggttta ctcccgccgt
     4081 taccaaactc ccccggatta tagttatgaa tatctccatt cggcgtatgc gtcgtacccc
     4141 agcccggccc gctgtttgga tccgtaccac cacctgatga agggccacct ttaccagacg
     4201 taccgttcac attcccactg gcctgaccac cattatgtcc cagacctgaa ttacccggac
     4261 ctcgaccgtc tccaccactc atatcgtttt cctctttgac atttaaaaca ataaattaaa
     4321 gccaacatac tgtacatata cacagtataa ttattacctt actcctcccg ttttcaggtg
     4381 tcaatatatg agattagttc tcatcttcag gcacaaaaaa gcgcccggag ccacctgtaa
     4441 gcagatcgcg tcttttcccg aaaatttctc atggcaacaa attttattat ttaagacatt
     4501 catcacactt acatttcaga tggtatagac acatctgaaa gctaactggc atgaggagag
     4561 gacctgcggt taaactgttc gggaaacctg agacgcccgg aggccactat gacgcacctg
     4621 aaactgactc ccgctgaaga aaagcgcctg gcggacgcct ttgtcgctca ggcactggcc
     4681 atgggcctga aagggaacaa aacgctgcca aaggcggtaa aacaacaggt gcgggaaagg
     4741 gtgcttcgtg ccattcagga cgaacgtgaa gccaggcggg cgcaggaaat gcgtcgggag
     4801 aaatacgagg ctacggaaac caccttcacc tggcagccac agcgccgccg gtaaggggta
     4861 tttaccataa cgtcgcatta cgcgcaccgc tcagacggtc tgagggcatt tccggcggct
     4921 acgggataaa acaggcaaca aaccacccgg aaaaccgccg gaaacgcgcc cggtaaactt
     4981 tatcctaatg catgcctatg cacgcaactg catggcgtgc agtttgacgt aaaatgggtg
     5041 ccgtaagccc ttttttacca gctttcgtct tcatcagcct gactgacacg agcatattct
     5101 ttcagaccgc cccctgctaa acttcttcat atcaccccat taatccggga gtctccgcaa
     5161 tgagcaacac tacacactac gaaaacgcca acttcctgcg ggaactggct gaaaacctgc
     5221 cccgcatact gccggaaagt ggcccggaca aagctgcgtt gttgcaatgc ctggctaacg
     5281 aagaactggc ccaggcagag tatgaagatc aggttcgcgc caaagtaacc gccgcccgtg
     5341 ctgacacgcg tccgggcatg accacggaac aactccgcca gcgcctgcat ggccgttatc
     5401 aggaactgcg cgatgccgta tgaggtggaa tggaaacagg gagccatcga ggatgtaacg
     5461 acgctgtttg actatatcgc ggaaaattca tccctgtggg atgcgcagaa cgttaccgat
     5521 cgcgttctca ctgcggcgga caaactggcc gacttcccgc gcctctatga agtggactca
     5581 cgctatggcg aggacgttcg ccggatcagt ctgatgggac agcatgtcct gtatgatgtt
     5641 gatgaccaga ccaggaaagt ccgggttctg gccgtggttg gccagcgcca gaatccccat
     5701 accgttcgct gataaccggt gacgggggcg caattcattg cgtggccgtc gccggttgga
     5761 caagcacagc gcgtcagcgt tttccccact gccaccaccg gcgcggtgtt ccggccggtg
     5821 tctctgctgt ctccggtttg tgttccagca gtctcatggc ctgcatttcc tgccgcagtc
     5881 cggccacctc ctccctgagt gcttttatct ccgcgatcaa cgcgtcgaag gccgtttttt
     5941 cagtctcatc cggcagtctc aacccgtccc gctcgtgagt ctcaccctgt cttaactcac
     6001 cgtacacccg gataagctcg ctggtatcca tcacccgacc accatcagct tccgtacggt
     6061 atgatacgcg gcctttcgcc atatcccgat acagggaact ccgggctttc cccgtcagtt
     6121 ccgtcgcctg tctcaccgtc acccacgcca ttgtctcacc ccgctatttt tgagacagta
     6181 tacccgacag acgcagaccg tgcccggaag gacagaaaca tgacgaagca ggaaaaaacc
     6241 gccctcaaca tggcgaaatt cattaaggac cagtcgctgc tgttgctcga gaaactgaac
     6301 gagctggata tggatacccc ggccgacatg tgcgaacggc tgcatgagga tgcagaaaag
     6361 ctctggctgg caatgcggga ccatctcggg gaggaataac agcaccggcc gagccggtgc
     6421 tgtccggcat tatttcatca ggcggcgcat acagaggagt attcccccga caagaatggc
     6481 cgccgtgcct ccctgcccga aatgcagaaa cagccagtca cggatctccg ggttcctcgc
     6541 cagaaactgc acaaccccgt agagcagcag aagcaccggc agtacgcgcc aaagcagttt
     6601 cagcaggttt ccggccagaa cgaccagcgt cccggccatg acagcgacca tcaacagggc
     6661 ttcacgcccc acggcaacaa cacgatttgt cataaaaacc tctctgagtg aatgtataag
     6721 ctcagtccat catcatgaat ttaaagcacg caaacagccg ctcccggtcc agctccaccg
     6781 ttttgcgggc ctcgccggtc tgcgggttca cgatttcatc caccgccaga atagcccgtt
     6841 gcaccctgac ctgcgtcgcc cggtccgggc aaatgtacca gatttcatcg atgccgttcg
     6901 cccggcggtt aaacagatac ccggacacca cctcctgata gcgcctgcgg ctcttcacgg
     6961 tgcgttccac ctcaaacgcc accgttctgc cgtccagctc cgccagcgcg tccggcacct
     7021 tcatcccttt cagggcaata cggtgcaggt accgccagcc ggtggccccc cgggcctcca
     7081 tggcgaggcg cagggactgc acggccagcc ggtgcggcag ctgcgccgcc gacacccgcg
     7141 acggctgaaa cggaataatg tccgtcagcg gctcgtcctc gtcgaacgag aacgccaccc
     7201 cgtgcggcgt cagcccccac acgctgacct gacggccgtc aaccgggtat ttcgcccgga
     7261 ccagcagccc tttcgccacc aggctgtcca ggaagcggta aaccggctgt accgccgcaa
     7321 tccccagccg ttgcgcaacc agctccgccg tggaacacag ttcttcccgc agccagcgca
     7381 gggtcagccg tgttttctcc gcgttccgtg cctgccgctt cgcgtggctg acgttgtatc
     7441 gctccagtgc catcagtaca gccccgcaaa atcatcatca cccggccgct gccgcccggc
     7501 ctccgactgg tactccgcca gcgggtccgt tttcgccagc acagggaagg ttttcagcgg
     7561 aatttcccgg cgatcaacac gcagcgggct gctgaacgcc agccgcgcca cgcccagccc
     7621 ggtcatcacc gcgaacccgt caggcagatg ttgcagggtg ttcacgtcaa acagcggccg
     7681 cgcctccttc tggatgaagc tgtccccgct gatatgctcc acgttccccg cctcccggct
     7741 tgcccggcgg cgctccacgt ccacccggat ctccccggtc tgtccggccg cccactgagc
     7801 ggactcctgg ctggccgccc ggtagaacca gcggatcggc gtgttatcca gtaccgtggt
     7861 tttcacaaaa tcagcgggca gatcctgccc gcactggccg aagtcgccca gcgactggtg
     7921 cgcgagcagc aggttgcagt cccggctgcg cagcgtcccc agcgcgttca gcacgtactt
     7981 cgacagcaga tatttaatct catcgagcat gatgctcgcg tgcggccacc tccggaactc
     8041 gtcccgcgca atgatgattt gcgcgcagcg ggcaaacagc atcttctgca cccggatcac
     8101 cgcctcatcg tccatcgagc cgatgacgta caggcagccg ccgccgttga ttatccccgc
     8161 cacgtcgatg ccgctgtccg tctgaaggac gctcaggtcg gccacgttct ccagcttggt
     8221 gatcagcccc ttcacgtcct ttttcagggc ctccggcagt gcgtacgccg ccgccagcac
     8281 ctgctgaata tttgccccct gcggaaactg ctccgcaatc agcttcgccg ctttctgctc
     8341 gctgatgcgg tagtggtccg ccacgtcgcc ggtctcactc aggttaaatc cggcaaccag
     8401 aagattcttc agggcgtact ggtcgagatc gcggaacaga ttcagctgcg ccggtttccc
     8461 cggccgcaga tccagcaggg tgaagtccgg gcagtgcgcc cggaagacgt gcggcgccca
     8521 cgcgtcccct ttcgggtcga agtacaccac cgcgtccccg aaatcgcgta cgcagcgaat
     8581 gagcgcgttg gtggccatca cgctcttgcc gctcccgggc aggccgagga tctgaatgtt
     8641 ggtcttgcgc caggtatcac gcgggaccag caccggctgg ccctgctcat ccttacccag
     8701 aaacaccgcc tgctgtttcc gggcctgctc cgtggaaaaa tcggccagcg cgttaaccgg
     8761 taccggctcc ccgaaatgca ggtggcggac gtcggtcatt t
//
