LOCUS       NZ_CP073004             9417 bp    DNA     circular CON 01-MAY-2024
DEFINITION  Klebsiella pneumoniae strain FO15 plasmid unnamed2, complete
            sequence.
ACCESSION   NZ_CP073004
VERSION     NZ_CP073004.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN18719513
            Assembly: GCF_022558365.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 9417)
  AUTHORS   Wang,Y.P., Chen,Y.H., Hung,I.C., Chu,P.H., Chang,Y.H., Lin,Y.T.,
            Yang,H.C. and Wang,J.T.
  TITLE     Transporter Genes and fosA Associated With Fosfomycin Resistance in
            Carbapenem-Resistant Klebsiella pneumoniae
  JOURNAL   Front Microbiol 13, 816806 (2022)
   PUBMED   35173700
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9417)
  AUTHORS   Wang,J.-T.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-APR-2021) Department of Microbiology, National Taiwan
            University College of Medicine, Ren'ai Road, Taipei 100, Taiwan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 02-SEP-2019
            Assembly Method                   :: Flye v. a3bd8dc
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 54.0x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022558365.1-RS_2024_05_01
            Annotation Date                   :: 05/01/2024 05:40:44
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,697
            CDSs (total)                      :: 5,575
            Genes (coding)                    :: 5,443
            CDSs (with protein)               :: 5,443
            Genes (RNA)                       :: 122
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 85
            ncRNAs                            :: 12
            Pseudo Genes (total)              :: 132
            CDSs (without protein)            :: 132
            Pseudo Genes (ambiguous residues) :: 0 of 132
            Pseudo Genes (frameshifted)       :: 50 of 132
            Pseudo Genes (incomplete)         :: 83 of 132
            Pseudo Genes (internal stop)      :: 15 of 132
            Pseudo Genes (multiple problems)  :: 16 of 132
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP073004.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..9417
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="FO15"
                     /host="Homo sapiens"
                     /db_xref="taxon:573"
                     /plasmid="unnamed2"
                     /geo_loc_name="Taiwan"
                     /collection_date="2017-10"
     gene            46..396
                     /locus_tag="KBT91_RS27820"
     CDS             46..396
                     /locus_tag="KBT91_RS27820"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004197756.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_004197756.1"
                     /translation="MYWLIAFLAFIFPGRSFADGYTAYYRCNGTQEASLTVKDNKLSMV
                     VGLSKFNRQLDTYRFKEKGIEVVMQRAASDDNSEAIMSFIMPDVNNMTLLVKNNGYIIV
                     KTTCWLTKTDKQ"
                     /name="hypothetical protein"
     gene            complement(466..732)
                     /locus_tag="KBT91_RS27825"
     CDS             complement(466..732)
                     /locus_tag="KBT91_RS27825"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000262326.1"
                     /GO_function="GO:0008657 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) inhibitor activity
                     [Evidence IEA]; GO:0042803 - protein homodimerization
                     activity [Evidence IEA]"
                     /GO_process="GO:0030541 - plasmid partitioning [Evidence
                     IEA]; GO:0051290 - protein heterotetramerization [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_004197762.1"
                     /translation="MVWTINYSDRALKSLRKMDKQNARRIVDFMSLRIAVAADPRQSGK
                     PLKGELGEFWRYRVGDYRVLCEIRDDELVILAATIGHRREVYD"
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            complement(716..940)
                     /locus_tag="KBT91_RS27830"
     CDS             complement(716..940)
                     /locus_tag="KBT91_RS27830"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000879771.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF6290 family protein"
                     /protein_id="WP_000879771.1"
                     /translation="MLAIRLSDEIESRLDSLAKQTGRTKTFYAREAILAHLEDLEDYYL
                     SAETAARVRRGDEAVHSSEDVRKSLGLDD"
                     /name="DUF6290 family protein"
     gene            complement(1607..1819)
                     /locus_tag="KBT91_RS27835"
     CDS             complement(1607..1819)
                     /locus_tag="KBT91_RS27835"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000137423.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MbeD family mobilization/exclusion protein"
                     /protein_id="WP_021527181.1"
                     /translation="MTELEKQLLSALEQLQQDYSKRLDEWESAFGEWRKMSGLMQRENA
                     ALSERVTRLSQQVERLSGQLQRLSR"
                     /name="MbeD family mobilization/exclusion protein"
     gene            complement(1826..2335)
                     /locus_tag="KBT91_RS27840"
     CDS             complement(1826..2335)
                     /locus_tag="KBT91_RS27840"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020325392.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MbeB family mobilization protein"
                     /protein_id="WP_032433972.1"
                     /translation="MNSLLTLAKDLEQKSKAQQQSTGEMLKAAFSEHEKSVRAELSESG
                     KRISAAIRAHEQGMSAAMQSNRLSVMRMVGRTWLTITMVSGLLFASLSGVLWYQGSLIA
                     SNLAEIDRQNAALSKLNAKTWGVTYLEDSNGRFLVLPKGTAVDRTQSWTVGNGRSKQNA
                     LRLVKE"
                     /name="MbeB family mobilization protein"
     gene            complement(<2370..3074)
                     /locus_tag="KBT91_RS28510"
                     /pseudo=""
     CDS             complement(<2370..3074)
                     /locus_tag="KBT91_RS28510"
                     /inference="COORDINATES: protein motif:HMM:NF015397.4"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="relaxase/mobilization nuclease domain-containing
                     protein"
                     /name="relaxase/mobilization nuclease domain-containing
                     protein"
     gene            complement(3013..3357)
                     /locus_tag="KBT91_RS27850"
     CDS             complement(3013..3357)
                     /locus_tag="KBT91_RS27850"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006122514.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobC family plasmid mobilization relaxosome
                     protein"
                     /protein_id="WP_062955149.1"
                     /translation="MAVKRTRFLGIRVTDGEYQQLLERCNGRQLAVWMRETCLDTRPAR
                     SLRLPSIDPVLLRQLAGMGNNLNQIARKINGGQWSGADRVQVVAALMAIDAELERLRHA
                     VLEKGADDDR"
                     /name="MobC family plasmid mobilization relaxosome protein"
     gene            complement(3347..3523)
                     /locus_tag="KBT91_RS27855"
     CDS             complement(3347..3523)
                     /locus_tag="KBT91_RS27855"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004197757.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_004197757.1"
                     /translation="MQKPKKKPLVVKKRSWHPAVMANLMRQAQEEDYRREQMAELERSA
                     RSHFADIGGEDGG"
                     /name="hypothetical protein"
     gene            4163..4321
                     /locus_tag="KBT91_RS28515"
     CDS             4163..4321
                     /locus_tag="KBT91_RS28515"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005761324.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /protein_id="WP_071596352.1"
                     /translation="MHEPPVQPDCCALSGNYHLESNPDGHAKTPLAAAIGNWIYTREIL
                     RGLEVGA"
                     /name="replication initiation protein"
     gene            4679..5005
                     /locus_tag="KBT91_RS27860"
     CDS             4679..5005
                     /locus_tag="KBT91_RS27860"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_050516389.1"
                     /translation="MRERTNIMLDIGLKQSLQRLSNKTKMSLSDLINQRLSGSLSVEER
                     IGEKPEWMRNLDPYLANHFSNIELPLPSPLKEYQEKMDEIDSIINDMMVLKEYFRAKFY
                     DEIK"
                     /name="hypothetical protein"
     gene            5031..5576
                     /locus_tag="KBT91_RS27865"
     CDS             5031..5576
                     /locus_tag="KBT91_RS27865"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004197758.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_023317533.1"
                     /translation="MFFKRYLTEKEIYKAALPIVRLQGRVNTSLRFLSKYSDVNKNGLI
                     ALHLNLLHFISYNIHGVESLKITQAGINKAVQQSPHADEIKNIAQAIGRKGPEYIEGLI
                     RNPWGKKNDNPLIFIMSIEESIKETLNSGYMLYRVAPITEGEAAAFMDVLKQLLLFEDN
                     FRLFGRDLVYKIEKLKIR"
                     /name="hypothetical protein"
     gene            complement(5812..>6096)
                     /locus_tag="KBT91_RS27870"
                     /pseudo=""
     CDS             complement(5812..>6096)
                     /locus_tag="KBT91_RS27870"
                     /inference="COORDINATES: protein motif:HMM:NF016710.4"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="MbeB family mobilization protein"
                     /name="MbeB family mobilization protein"
     gene            complement(<5990..6844)
                     /locus_tag="KBT91_RS27875"
                     /pseudo=""
     CDS             complement(<5990..6844)
                     /locus_tag="KBT91_RS27875"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000635827.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="relaxase/mobilization nuclease domain-containing
                     protein"
                     /name="relaxase/mobilization nuclease domain-containing
                     protein"
     gene            complement(6834..7178)
                     /locus_tag="KBT91_RS27880"
     CDS             complement(6834..7178)
                     /locus_tag="KBT91_RS27880"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006122514.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobC family plasmid mobilization relaxosome
                     protein"
                     /protein_id="WP_062955149.1"
                     /translation="MAVKRTRFLGIRVTDGEYQQLLERCNGRQLAVWMRETCLDTRPAR
                     SLRLPSIDPVLLRQLAGMGNNLNQIARKINGGQWSGADRVQVVAALMAIDAELERLRHA
                     VLEKGADDDR"
                     /name="MobC family plasmid mobilization relaxosome protein"
     gene            complement(7168..7344)
                     /locus_tag="KBT91_RS27885"
     CDS             complement(7168..7344)
                     /locus_tag="KBT91_RS27885"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004197757.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_004197757.1"
                     /translation="MQKPKKKPLVVKKRSWHPAVMANLMRQAQEEDYRREQMAELERSA
                     RSHFADIGGEDGG"
                     /name="hypothetical protein"
     gene            7984..8142
                     /locus_tag="KBT91_RS28520"
     CDS             7984..8142
                     /locus_tag="KBT91_RS28520"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005761324.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /protein_id="WP_071596352.1"
                     /translation="MHEPPVQPDCCALSGNYHLESNPDGHAKTPLAAAIGNWIYTREIL
                     RGLEVGA"
                     /name="replication initiation protein"
     gene            8500..8826
                     /locus_tag="KBT91_RS27890"
     CDS             8500..8826
                     /locus_tag="KBT91_RS27890"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_050516389.1"
                     /translation="MRERTNIMLDIGLKQSLQRLSNKTKMSLSDLINQRLSGSLSVEER
                     IGEKPEWMRNLDPYLANHFSNIELPLPSPLKEYQEKMDEIDSIINDMMVLKEYFRAKFY
                     DEIK"
                     /name="hypothetical protein"
     gene            8852..9397
                     /locus_tag="KBT91_RS27895"
     CDS             8852..9397
                     /locus_tag="KBT91_RS27895"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004197758.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_023317533.1"
                     /translation="MFFKRYLTEKEIYKAALPIVRLQGRVNTSLRFLSKYSDVNKNGLI
                     ALHLNLLHFISYNIHGVESLKITQAGINKAVQQSPHADEIKNIAQAIGRKGPEYIEGLI
                     RNPWGKKNDNPLIFIMSIEESIKETLNSGYMLYRVAPITEGEAAAFMDVLKQLLLFEDN
                     FRLFGRDLVYKIEKLKIR"
                     /name="hypothetical protein"
     Typing          complement(3610..3686)
                     /name="MOBP"
                     /typing="oriT"
                     /tool="MOB-suite"
                     /identity="91.25"
                     /coverage="98.0"
                     /evalue="1.04e-21"
     Typing          complement(7431..7507)
                     /name="MOBP"
                     /typing="oriT"
                     /tool="MOB-suite"
                     /identity="91.25"
                     /coverage="98.0"
                     /evalue="1.04e-21"
     Typing          3875..4272
                     /name="rep_cluster_2370"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="89.526"
                     /coverage="91.0"
                     /evalue="3.03e-139"
     Typing          7696..8093
                     /name="rep_cluster_2370"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="89.526"
                     /coverage="91.0"
                     /evalue="3.03e-139"
     Typing          complement(1492..3023)
                     /name="MOBP"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="99.804"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(5862..6844)
                     /name="MOBP"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="93.902"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 atgaaagaga ggatagtgaa atgtgtaata ccaagattct caactatgta ttggttaatt
       61 gcgttcctag catttatatt ccccggtcga tcttttgctg acggttacac cgcttactac
      121 cgatgtaatg gtactcagga agcatctctt actgttaaag ataacaaact aagtatggtt
      181 gtaggtcttt ctaagtttaa taggcaactg gatacttata gattcaaaga aaagggaatc
      241 gaagtagtaa tgcagagagc tgcttctgat gataactctg aggccataat gtcttttatt
      301 atgcctgacg ttaacaatat gaccttatta gttaaaaata acggctacat tatcgttaag
      361 acaacctgct ggttaactaa aaccgacaaa cagtagaaca cgtagttagt cgagtattta
      421 ccataatacc tgttgtcggc atcaaaaaag cccgcatagc gggcttcagt cgtaaacttc
      481 gcggcgatgt ccaatcgtgg cggcaaggat aacaagctcg tcatctcgga tctcacacag
      541 aacgcgataa tctcccaccc gatagcgcca gaactcgccc agctcacctt tgagcggctt
      601 ccctgactgg cgaggatcgg cagcaactgc aatgcgtaaa ctcataaaat ccacaatccg
      661 tcgtgcgttc tgtttgtcca tcttgcgtaa cgatttgagc gcccgatcgg aatagttaat
      721 cgtccagacc aagtgacttc ctcacgtctt cagacgaatg cactgcttca tcaccacggc
      781 gaacgcgtgc agcagtttct gctgaaagat aataatcctc caggtcttcc agatgcgcca
      841 gtattgcttc ccgcgcataa aacgtctttg ttctgccggt ttgcttcgcc agcgagtcca
      901 gacgggactc aatctcatca gataaccgga tagcaagcat ataaacctcc cgaacaccat
      961 ttgctataca tgtatatcaa cagtaccaca atcaacctaa aagaacaaaa aataatcttg
     1021 ttagcccctc ttgataatcc gtaacgcggt caatatatct agcttgaggg ctttcctctt
     1081 aactattgaa aggataacga ttatgggtct taagccgggt ccgaaacgaa ttgccgattc
     1141 aacaggggaa cctgataaac gccagcgtga caataaaaaa acgccgggaa atactgacaa
     1201 attgaaaccc agcaaatctt caaaaaaata agtcagtagt taaaagccct ccggggcttt
     1261 tttgtatctg ccgttcacgc tgattaaaca taacacccgt tgcccgcacc gccccggacg
     1321 ggttcgccgc gaacggggtg gcagtcaggt aaaaccggca acaaaccacc cgataaaccg
     1381 ccccgttcgc gacagataaa ttttacctgg ctgcatagcc atgcagccag gtgaatgaca
     1441 tccggtttca gcgtaaatgc ccgatgagaa ccctgttttc ctgcatttca gcccagcgac
     1501 ggaccgtcat agcttcgctg ccgggaacgc gcttccgtca gttccttttc gtgctgccgt
     1561 tgctcgtgcg cccgttctgc ggccacggcc atctcatgac gctgcactac cggctcaaac
     1621 gctgcagttg cccgctcaag cgttccacct gctgactcaa gcgcgtcacg cgctcgctca
     1681 gcgccgcgtt ctcccgttgc ataagccctg acattttccg ccattccccg aaggcgctct
     1741 cccactcgtc cagccttttc gagtagtcct gctgtagctg ctctaatgcg ctcagcaact
     1801 gtttttccag ctcggtcatc ggcacttact ccttcaccag tctcagcgcg ttctgcttcg
     1861 accgcccgtt cccgaccgtc cagctctgcg tcctgtctac ggccgtcccc ttcggcagca
     1921 ccagaaaacg tccgttgctg tcttccaggt acgtcacgcc ccaggtcttc gcgttcagct
     1981 tcgacagcgc tgcgttctgc cggtcgattt cggccagatt tgacgctatc aagctcccct
     2041 gataccacaa caccccgctc aggctggcga acagcagtcc tgacaccatc gtgatggtca
     2101 gccatgtccg cccgaccata cgcatcacgc tcaggcggtt cgactgcatg gccgcgctca
     2161 taccctgctc gtgggcgcgg atggcggcgc tgattctctt cccgctttcg ctcagttccg
     2221 ctctgacaga cttctcgtgc tcgctgaatg cggctttcag catttcgccg gtactctgct
     2281 gctgcgcttt cgatttctgc tctaagtcct tcgccagcgt taaaagactg ttcatagatg
     2341 gctcccttaa gtcggatgtt tcgccctccg tccgggtcgg caatgctgat gctgctcttt
     2401 gtggtgcgca cgacctcaaa acctgcgctt tccagcgcct cagtgacgtc ctgacgcgtt
     2461 ttaagctccc ctgacgaggc gagggccagt aagccccgcg taatagcctc tgcggcttcc
     2521 tgcttcgttt tgggtaacga agatggcgtc accagcgcgc gccggttctc cggtgcgttc
     2581 gggtcgtgca gccccagtcg cccgttcacc acggtctgcc acgcatcgat gcgcggacgg
     2641 tctgcccggt cgtagtacgg ctggagacgc ctgccggtca gcagttccgt gttcggtacc
     2701 agaaaattca gttccagccg ccccttgtcc cggtgttcaa cccacagcac gctgtactgg
     2761 tctttatcga gtccgggcat cagaacccgc tcgaagctcg ccatcagctt ttcacgctgg
     2821 ccgggcggta aatcctgttc agcaaaagac aggacgccgg aggtgtactt tttggcgtag
     2881 ggcgaggcgt cgataagctc ccggacctcc tccggctttc cctgcaggac gatggccccg
     2941 tcgcgctggc ggtctttccc cagcagataa tccaccggcc cggcaccgcc gcctcgccct
     3001 cgcggatgaa acttaacgat catcgtctgc ccccttttcc agcacggcat gccgcagccg
     3061 ctcgagttcg gcatcaatgg ccatcagcgc ggccaccacc tgaacccggt cagcgcctga
     3121 ccactggccg ccgttaattt tccgggcgat ctggttgagg ttgttcccca tcccggcaag
     3181 ctggcgcagc aaaaccggat cgatggacgg cagccgcaac gaccgcgccg ggcgcgtatc
     3241 gagacaggtt tcccgcatcc acaccgccag ttgccttcca ttgcagcgct ccagcagctg
     3301 ctggtactcc ccatcggtca cccggatacc taaaaaacgg gtacgcttaa ccgccatcct
     3361 ctcctccgat atccgcaaaa tgtgaccggg ctgaacgctc aagctctgcc atctgctccc
     3421 ggcggtaatc ttcctcctgt gcctgacgca tcagatttgc catcactgcc ggatgccagg
     3481 atcttttttt tacgacgagc ggcttcttct tcggcttctg cattatccct ccttcgcaaa
     3541 cgccggacgg cacggaaaag ttttccgggt cgctccggcg ttggacaagc gccagcgcgt
     3601 cagtggtgtt agcgggtttc ggggcgcagc cctgaaccag tcacagcgtt tacgctgtgt
     3661 atactggctt actatgttgg catgagagca cgattcatga aagtgcctca tgtggcaggt
     3721 gtgatatgtg gctcaggagc gtccgcaata ccatgcacgg acagatgaaa tgacgcctcc
     3781 tcgctcactc ggtagctgcg ctcctgccgt tcggctgcgg cgggcgtgac cgactcacgg
     3841 ataacgggat aaagcaaagg cgctcaaatc agaaagggcc ggagaaaagg atgcggcgtt
     3901 gccgtttttc cataggctcc gcctcccctg acgagcatca cagaaatgga cgctcaagtc
     3961 agaggaggac gaaacccgac aggacttaaa gatgccggtg atttctctcc ggcggctccc
     4021 tcgtgcgctc tcctgttccg accctgccgt ttaccggata cctgttccgc ctttttccct
     4081 ttcgggaagc gtggcgcttt ctcatagctc acgctgctgg tatctcggct cggtttaggt
     4141 cgttcgctcc aagctgggct gtatgcacga accccccgtt cagcccgact gctgcgccct
     4201 ttccggtaac tatcatcttg agtccaaccc ggacggacac gcaaaaacgc cactggcagc
     4261 agccattggt aactggatat atacgagaga gatattgaga ggtcttgaag tgggtgccta
     4321 actgcggcta cactgaaaga acagttttgg tatctgcggt ctcgtatacc cagttacccg
     4381 gttaagcagt tccccaactg acttaacctt cgatcaaacc gcctccccag gcggtttttt
     4441 cgtttacagt gcaagagatt acgcgcagaa aaaaaggatc tcaagaagat cctttaaatg
     4501 atcgtcagtt ctgttatccc cggagctcca tccatcccac ggaaaaacac ccgccactga
     4561 tgccctcagc gcactgcaca tcatgtacaa accactccct ccctcctttt ttattgcgtt
     4621 tcttaatgcg caatggtagc tttgtgcgca acaaaaaacg caatagcaag ggggggtaat
     4681 gagagaaaga acaaatatca tgctagatat aggattaaag caatccttac aacggctttc
     4741 gaataaaacc aaaatgagtc taagtgatct tattaaccag agattatcag gttcactttc
     4801 agttgaagaa cgcattggcg aaaagcctga atggatgaga aaccttgatc cctatctcgc
     4861 caatcacttt tcaaatattg agttaccgct cccttcacca ttaaaagaat accaagaaaa
     4921 aatggatgag atagattcaa ttattaatga catgatggtt ctaaaggaat atttcagagc
     4981 taagttttac gacgaaataa aataggcacg ctatacggag gcggagaatt atgtttttta
     5041 aacggtattt aacggagaag gaaatataca aggcagcact cccaattgtt aggcttcaag
     5101 ggagagttaa cacttcatta cgttttttat ccaaatactc agatgtaaac aaaaatggat
     5161 taattgcatt gcatcttaat ttattacatt ttatctcata caacatacac ggtgtagagt
     5221 ctctgaaaat cactcaagca ggcataaaca aagctgtaca acaaagccct cacgcagatg
     5281 aaataaaaaa tattgcgcag gcaataggac gcaaaggacc tgagtacatc gaaggattaa
     5341 ttagaaaccc atgggggaag aaaaatgata atccactaat atttataatg agcattgaag
     5401 aaagtataaa agaaaccctt aactcaggtt atatgttata tagagtagct cccataactg
     5461 agggtgaagc agctgctttc atggatgttc ttaaacaatt attattattt gaggataatt
     5521 ttcgcctttt tggtagagac ttggtttata aaatagaaaa attaaaaatc agataacaaa
     5581 gtatggtgaa cgaaaaatga aagagaggat agtgaaatgt gtaataccaa gattctcaac
     5641 tatgtattgg ttaattgcgt tcctagcatt tatattcccc ggtcgatctt ttgctgacgg
     5701 ttacaccgct tactaccgat gtaatggtac tcaggaagca tctcttactg ttaaagataa
     5761 caaactaagt atggttgtag gtctttctaa gtttaatagg caactggata cttatagatt
     5821 caaagaaaag ggaatcgaag tagtaatgca gagagctgct tctgatgata actctgaggc
     5881 cataatgtct tttattatgc ctgacgttaa caatatgacc ttattagtta aaaataacat
     5941 acgcatcacg ctcaggcggt tcgactgcat ggccgcgctc ataccctgct cgtgggcgcg
     6001 gatggcggcg ctgattctct tcccgctttc gctcagttcc gctctgacag acttctcgtg
     6061 ctcgctgaat gcggctttca gcatttcgcc ggtactctgc tgctgcgctt tcgatttctg
     6121 ctctaagtcc ttcgccagcg ttaaaagact gttcatagat ggctccctta agtcggatgt
     6181 ttcgccctcc gtccgggtcg gcaatgctga tgctgctctt tgtggtgcgc acgacctcaa
     6241 aacctgcgct ttccagcgcc tcagtgacgt cctgacgcgt tttaagctcc cctgacgagg
     6301 cgagggccag taagccccgc gtaatagcct ctgcggcttc ctgcttcgtt ttgggtaacg
     6361 aagatggcgt caccagcgcg cgccggttct ccggtgcgtt cgggtcgtgc agccccagtc
     6421 gcccgttcac cacggtctgc cacgcatcga tgcgcggacg gtctgcccgg tcgtagtacg
     6481 gctggagacg cctgccggtc agcagttccg tgttcggtac cagaaaattc agttccagcc
     6541 gccccttgtc ccggtgttca acccacagca cgctgtactg gtctttatcg agtccgggca
     6601 tcagaacccg ctcgaagctc gccatcagct tttcacgctg gccgggcggt aaatcctgtt
     6661 cagcaaaaga caggacgccg gaggtgtact ttttggcgta gggcgaggcg tcgataagct
     6721 cccggacctc ctccggcttt ccctgcagga cgatggcccc gtcgcgctgg cggtctttcc
     6781 ccagcagata atccaccggc ccggcaccgc cgcctcgccc tcgcggatga aacttaacga
     6841 tcatcgtctg cccccttttc cagcacggca tgccgcagcc gctcgagttc ggcatcaatg
     6901 gccatcagcg cggccaccac ctgaacccgg tcagcgcctg accactggcc gccgttaatt
     6961 ttccgggcga tctggttgag gttgttcccc atcccggcaa gctggcgcag caaaaccgga
     7021 tcgatggacg gcagccgcaa cgaccgcgcc gggcgcgtat cgagacaggt ttcccgcatc
     7081 cacaccgcca gttgccttcc attgcagcgc tccagcagct gctggtactc cccatcggtc
     7141 acccggatac ctaaaaaacg ggtacgctta accgccatcc tctcctccga tatccgcaaa
     7201 atgtgaccgg gctgaacgct caagctctgc catctgctcc cggcggtaat cttcctcctg
     7261 tgcctgacgc atcagatttg ccatcactgc cggatgccag gatctttttt ttacgacgag
     7321 cggcttcttc ttcggcttct gcattatccc tccttcgcaa acgccggacg gcacggaaaa
     7381 gttttccggg tcgctccggc gttggacaag cgccagcgcg tcagtggtgt tagcgggttt
     7441 cggggcgcag ccctgaacca gtcacagcgt ttacgctgtg tatactggct tactatgttg
     7501 gcatgagagc acgattcatg aaagtgcctc atgtggcagg tgtgatatgt ggctcaggag
     7561 cgtccgcaat accatgcacg gacagatgaa atgacgcctc ctcgctcact cggtagctgc
     7621 gctcctgccg ttcggctgcg gcgggcgtga ccgactcacg gataacggga taaagcaaag
     7681 gcgctcaaat cagaaagggc cggagaaaag gatgcggcgt tgccgttttt ccataggctc
     7741 cgcctcccct gacgagcatc acagaaatgg acgctcaagt cagaggagga cgaaacccga
     7801 caggacttaa agatgccggt gatttctctc cggcggctcc ctcgtgcgct ctcctgttcc
     7861 gaccctgccg tttaccggat acctgttccg cctttttccc tttcgggaag cgtggcgctt
     7921 tctcatagct cacgctgctg gtatctcggc tcggtttagg tcgttcgctc caagctgggc
     7981 tgtatgcacg aaccccccgt tcagcccgac tgctgcgccc tttccggtaa ctatcatctt
     8041 gagtccaacc cggacggaca cgcaaaaacg ccactggcag cagccattgg taactggata
     8101 tatacgagag agatattgag aggtcttgaa gtgggtgcct aactgcggct acactgaaag
     8161 aacagttttg gtatctgcgg tctcgtatac ccagttaccc ggttaagcag ttccccaact
     8221 gacttaacct tcgatcaaac cgcctcccca ggcggttttt tcgtttacag tgcaagagat
     8281 tacgcgcaga aaaaaaggat ctcaagaaga tcctttaaat gatcgtcagt tctgttatcc
     8341 ccggagctcc atccatccca cggaaaaaca cccgccactg atgccctcag cgcactgcac
     8401 atcatgtaca aaccactccc tccctccttt tttattgcgt ttcttaatgc gcaatggtag
     8461 ctttgtgcgc aacaaaaaac gcaatagcaa gggggggtaa tgagagaaag aacaaatatc
     8521 atgctagata taggattaaa gcaatcctta caacggcttt cgaataaaac caaaatgagt
     8581 ctaagtgatc ttattaacca gagattatca ggttcacttt cagttgaaga acgcattggc
     8641 gaaaagcctg aatggatgag aaaccttgat ccctatctcg ccaatcactt ttcaaatatt
     8701 gagttaccgc tcccttcacc attaaaagaa taccaagaaa aaatggatga gatagattca
     8761 attattaatg acatgatggt tctaaaggaa tatttcagag ctaagtttta cgacgaaata
     8821 aaataggcac gctatacgga ggcggagaat tatgtttttt aaacggtatt taacggagaa
     8881 ggaaatatac aaggcagcac tcccaattgt taggcttcaa gggagagtta acacttcatt
     8941 acgtttttta tccaaatact cagatgtaaa caaaaatgga ttaattgcat tgcatcttaa
     9001 tttattacat tttatctcat acaacataca cggtgtagag tctctgaaaa tcactcaagc
     9061 aggcataaac aaagctgtac aacaaagccc tcacgcagat gaaataaaaa atattgcgca
     9121 ggcaatagga cgcaaaggac ctgagtacat cgaaggatta attagaaacc catgggggaa
     9181 gaaaaatgat aatccactaa tatttataat gagcattgaa gaaagtataa aagaaaccct
     9241 taactcaggt tatatgttat atagagtagc tcccataact gagggtgaag cagctgcttt
     9301 catggatgtt cttaaacaat tattattatt tgaggataat tttcgccttt ttggtagaga
     9361 cttggtttat aaaatagaaa aattaaaaat cagataacaa agtatggtga acgaaaa
//
