LOCUS       NZ_CP070533            25440 bp    DNA     circular CON 29-APR-2024
DEFINITION  Enterobacter hormaechei strain EC48293 plasmid p48293_1, complete
            sequence.
ACCESSION   NZ_CP070533
VERSION     NZ_CP070533.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN16933270
            Assembly: GCF_016939555.1
KEYWORDS    RefSeq.
SOURCE      Enterobacter hormaechei
  ORGANISM  Enterobacter hormaechei
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Enterobacter; Enterobacter cloacae complex.
REFERENCE   1  (bases 1 to 25440)
  AUTHORS   Kraftova,L., Finianos,M., Studentova,V., Chudejova,K., Jakubu,V.,
            Zemlickova,H., Papagiannitsis,C.C., Bitar,I. and Hrabak,J.
  TITLE     Evidence of an epidemic spread of KPC-producing Enterobacterales in
            Czech hospitals
  JOURNAL   Sci Rep 11 (1), 15732 (2021)
   PUBMED   34344951
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 25440)
  AUTHORS   Bitar,I.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-FEB-2021) Microbiology, Charles University in Prague,
            Alej Svobody 1655/76, Plzen 1 32300, Czech Republic
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Microbial Assembly v. 1.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 250X
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_016939555.1-RS_2024_04_29
            Annotation Date                   :: 04/29/2024 03:48:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,165
            CDSs (total)                      :: 5,051
            Genes (coding)                    :: 4,953
            CDSs (with protein)               :: 4,953
            Genes (RNA)                       :: 114
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 83
            ncRNAs                            :: 6
            Pseudo Genes (total)              :: 98
            CDSs (without protein)            :: 98
            Pseudo Genes (ambiguous residues) :: 0 of 98
            Pseudo Genes (frameshifted)       :: 35 of 98
            Pseudo Genes (incomplete)         :: 70 of 98
            Pseudo Genes (internal stop)      :: 9 of 98
            Pseudo Genes (multiple problems)  :: 15 of 98
            Pseudo Genes (short protein)      :: 1 of 98
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP070533.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..25440
                     /organism="Enterobacter hormaechei"
                     /mol_type="genomic DNA"
                     /strain="EC48293"
                     /isolation_source="Sputum-aspirate"
                     /host="Homo sapiens"
                     /db_xref="taxon:158836"
                     /plasmid="p48293_1"
                     /geo_loc_name="Czech Republic: Praha"
                     /lat_lon="50.07 N 14.35 E"
                     /collection_date="2019-01-02"
                     /collected_by="Fakultn nemocnice Krlovsk Vinohrady"
     gene            <2..73
                     /locus_tag="JW293_RS25780"
                     /pseudo=""
     CDS             <2..73
                     /locus_tag="JW293_RS25780"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_005221000.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /name="hypothetical protein"
     gene            129..431
                     /locus_tag="JW293_RS01950"
                     /old_locus_tag="JW293_01950"
     CDS             129..431
                     /locus_tag="JW293_RS01950"
                     /old_locus_tag="JW293_01950"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000679428.1"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="multidrug efflux SMR transporter"
                     /protein_id="WP_050346403.1"
                     /translation="MATSALKSSEGFTKLAPSAVVIIGYGIAFYFLSLVLKSIPVGVAY
                     AVWSGLGVVIITAIAWLLHGQKLDAWGFVGMGLIIAAFLLARSPSWKSLRRPTPW"
                     /name="multidrug efflux SMR transporter"
     gene            425..1264
                     /gene="sul1"
                     /locus_tag="JW293_RS01955"
                     /old_locus_tag="JW293_01955"
     CDS             425..1264
                     /gene="sul1"
                     /locus_tag="JW293_RS01955"
                     /old_locus_tag="JW293_01955"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000259031.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sulfonamide-resistant dihydropteroate synthase
                     Sul1"
                     /protein_id="WP_000259031.1"
                     /translation="MVTVFGILNLTEDSFFDESRRLDPAGAVTAAIEMLRVGSDVVDVG
                     PAASHPDARPVSPADEIRRIAPLLDALSDQMHRVSIDSFQPETQRYALKRGVGYLNDIQ
                     GFPDPALYPDIAEADCRLVVMHSAQRDGIATRTGHLRPEDALDEIVRFFEARVSALRRS
                     GVAADRLILDPGMGFFLSPAPETSLHVLSNLQKLKSALGLPLLVSVSRKSFLGATVGLP
                     VKDLGPASLAAELHAIGNGADYVRTHAPGDLRSAITFSETLAKFRSRDARDRGLDHA"
                     /name="sul1"
     gene            1392..1595
                     /locus_tag="JW293_RS01960"
                     /old_locus_tag="JW293_01960"
     CDS             1392..1595
                     /locus_tag="JW293_RS01960"
                     /old_locus_tag="JW293_01960"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000376616.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000376616.1"
                     /translation="MDSEEPPNVRVACSGDIDEVVRLMHDAAAWMSAKGTPAWDVARID
                     RTFAETFVLRSELLGIASENGK"
                     /name="hypothetical protein"
     gene            1751..2956
                     /gene="chrA"
                     /locus_tag="JW293_RS01965"
                     /old_locus_tag="JW293_01965"
     CDS             1751..2956
                     /gene="chrA"
                     /locus_tag="JW293_RS01965"
                     /old_locus_tag="JW293_01965"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004896675.1"
                     /GO_function="GO:0015109 - chromate transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0015703 - chromate transport [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="chromate efflux transporter"
                     /protein_id="WP_000184001.1"
                     /translation="MTNNPTDDSRPWSVFLIFLRLGLTSFGGPIAHLGYFRAEFVTRRR
                     WLSERSYADLVALCQFLPGPASSQVGIAVGLSRAGYSGALAAWAGFTLPSAIALILFAL
                     GISSYGDYVSQGALHGLKVVAVAVVAQAVWGMARNLCTDGLRVTIMAIATCVVLLVPSA
                     WGQVGVIAIAGIAGRLLFKPAKVVEHDPLPITVSHRAGVLWLSLFFVLLIGLPVLAELM
                     PSQTMAMVDSFYRVGSLVFGGGHVVLPLLQAEVVPSGWVNNESFLAGYGAAQAVPGPLF
                     TFAAFLGASMNTAPSGWIGGIVCLLAIFAPSFLLVVGSMPFWERLRRNTGIQAALAGIN
                     AAVVGLLLAALYQPVWTSAIFQPQDFGLALVALVALMFWKLPPWLVVLGSGAAGWLLSV
                     AL"
                     /name="chrA"
     gene            2967..3272
                     /locus_tag="JW293_RS01970"
                     /old_locus_tag="JW293_01970"
     CDS             2967..3272
                     /locus_tag="JW293_RS01970"
                     /old_locus_tag="JW293_01970"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000130000.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="PadR family transcriptional regulator"
                     /protein_id="WP_000130000.1"
                     /translation="MTDKDLYGGLIRLHILHHAAEEPVFGLGIIEELRRHGYEMSAGTV
                     YPMLHGLEKKGYLTSRHERTGRRERRVYDITEQGRTALADAKTKVKELFGELVEGG"
                     /name="PadR family transcriptional regulator"
     gene            <3316..3381
                     /locus_tag="JW293_RS01975"
                     /old_locus_tag="JW293_01975"
                     /pseudo=""
     CDS             <3316..3381
                     /locus_tag="JW293_RS01975"
                     /old_locus_tag="JW293_01975"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_005229646.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="EAL domain-containing protein"
                     /name="EAL domain-containing protein"
     gene            3499..4263
                     /locus_tag="JW293_RS01980"
                     /old_locus_tag="JW293_01980"
     CDS             3499..4263
                     /locus_tag="JW293_RS01980"
                     /old_locus_tag="JW293_01980"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001389365.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS6100 family transposase"
                     /protein_id="WP_001389365.1"
                     /translation="MTDFKWRHFQGDVILWAVRWYCRYPISYRDLEEMLAERGISVDHT
                     TIYRWVQCYAPEMEKRLRWFWRRGFDPSWRLDETYVKVRGKWTYLYRAVDKRGDTIDFY
                     LSPTRSAKAAKRFLGKALRGLKHWEKPATLNTDKAPSYGAAITELKREGKLDRETAHRQ
                     VKYLNNVIEADHGKLKILIKPVRGFKSIPTAYATIKGFEVMRALRKGQARPWCLQPGIR
                     GEVRLVERAFGIGPSALTEAMGMLNHHFAAAA"
                     /name="IS6-like element IS6100 family transposase"
     gene            complement(4756..5340)
                     /gene="mphR(A)"
                     /locus_tag="JW293_RS01985"
                     /old_locus_tag="JW293_01985"
     CDS             complement(4756..5340)
                     /gene="mphR(A)"
                     /locus_tag="JW293_RS01985"
                     /old_locus_tag="JW293_01985"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001137892.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="macrolide-binding transcriptional repressor
                     MphR(A)"
                     /protein_id="WP_001137892.1"
                     /translation="MPRPKLKSDDEVLEAATVVLKRCGPIEFTLSGVAKEVGLSRAALI
                     QRFTNRDTLLVRMMERGVEQVRHYLNAIPIGAGPQGLWEFLQVLVRSMNTRNDFSVNYL
                     ISWYELQVPELRTLAIQRNRAVVEGIRKRLPPGAPAAAELLLHSVIAGATMQWAVDPDG
                     ELADHVLAQIAAILCLMFPEHDDFQLLQAHA"
                     /name="mphR(A)"
     gene            complement(5340..6578)
                     /gene="mrx(A)"
                     /locus_tag="JW293_RS01990"
                     /old_locus_tag="JW293_01990"
                     /gene_synonym="mrx"
     CDS             complement(5340..6578)
                     /gene="mrx(A)"
                     /locus_tag="JW293_RS01990"
                     /old_locus_tag="JW293_01990"
                     /gene_synonym="mrx"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000004159.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="macrolide resistance MFS transporter Mrx(A)"
                     /protein_id="WP_000004159.1"
                     /translation="MSERRYSPLATLFAATFLFRIGNAVAALALPWFVLSHTKSAAWAG
                     ATAASSVIATIIGAWVGGGLVDRFGRAPVALISGVVGGVAMASIPLLDAVGALSNTGLI
                     ACVVLGAAFDAPGMAAQDSELPKLGHVAGLSVERVSSLKAVIGNVAILGGPALGGAAIG
                     LLGAAPTLGLTAFCSVLAGLLGAWVLPARAARTMTTTATLSMRAGVAFLWSEPLLRPLF
                     GIVMIFVGIVGANGSVIMPALFVDAGRQVAELGLFSSMMGAGGLLGIAIHASVGARISA
                     QNWLAVAFCGSAVGSLLLSQLPGVPVLMLLGALVGLLTGSVSPILNAAIYNRTPPELLG
                     RVLGTVSAVMLSASPMVMLAAGAFVDLAGPLPGLVVSAVFAGLVALLSLRLQFATMAAA
                     ATASAPTHTEGEH"
                     /name="mrx(A)"
     gene            complement(6575..7480)
                     /locus_tag="JW293_RS01995"
                     /old_locus_tag="JW293_01995"
     CDS             complement(6575..7480)
                     /locus_tag="JW293_RS01995"
                     /old_locus_tag="JW293_01995"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000219391.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Mph(A) family macrolide 2'-phosphotransferase"
                     /protein_id="WP_000219391.1"
                     /translation="MTVVTTADTSQLYALAARHGLKLHGPLTVNELGLDYRIVIATVDD
                     GRRWVLRIPRRAEVSAKVEPEARVLAMLKNRLPFAVPDWRVANAELVAYPMLEDSTAMV
                     IQPGSSTPDWVVPQDSEVFAESFATALAALHAVPISAAVDAGMLIRTPTQARQKVADDV
                     DRVRREFVVNDKRLHRWQRWLDDDSSWPDFSVVVHGDLYVGHVLIDNTERVSGMIDWSE
                     ARVDDPAIDMAAHLMVFGEEGLAKLLLTYEAAGGRVWPRLAHHIAERLAFGAVTYALFA
                     LDSGNEEYLAAAKAQLAAAE"
                     /name="Mph(A) family macrolide 2'-phosphotransferase"
     gene            complement(7602..8306)
                     /locus_tag="JW293_RS02000"
                     /old_locus_tag="JW293_02000"
     CDS             complement(7602..8306)
                     /locus_tag="JW293_RS02000"
                     /old_locus_tag="JW293_02000"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_005221000.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS26 family transposase"
                     /protein_id="WP_001067834.1"
                     /translation="MNPFKGRHFQRDIILWAVRWYCKYGISYRELQEMLAERGVNVDHS
                     TIYRWVQRYAPEMEKRLRWYWRNPSDLCPWHMDETYVKVNGRWAYLYRAVDSRGRTVDF
                     YISSRRNSKAAYRFLGKILNNVKKWQIPRFINTDKAPAYGRALALLKREGRCPSDVEHR
                     QIKYRNNVIECDHGKLKRIIGATLGFKSMKTAYATIKGIEVMRALRKGQASAFYYGDPL
                     GEMRLVSRVFEM"
                     /name="IS6-like element IS26 family transposase"
     gene            <8371..8583
                     /locus_tag="JW293_RS02005"
                     /old_locus_tag="JW293_02005"
                     /pseudo=""
     CDS             <8371..8583
                     /locus_tag="JW293_RS02005"
                     /old_locus_tag="JW293_02005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003833285.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="DUF4440 domain-containing protein"
                     /name="DUF4440 domain-containing protein"
     gene            complement(8625..9269)
                     /locus_tag="JW293_RS02010"
                     /old_locus_tag="JW293_02010"
     CDS             complement(8625..9269)
                     /locus_tag="JW293_RS02010"
                     /old_locus_tag="JW293_02010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017900990.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="quinolone resistance pentapeptide repeat protein
                     QnrB2"
                     /protein_id="WP_012695489.1"
                     /translation="MALALVGEKINRNRFTGEKIENSTFFNCDFSGADLSGTEFIGCQF
                     YDRESQKGCNFSRAMLKDAIFKSCDLSMADFRNASALGIEIRHCRAQGADFRGASFMNM
                     ITTRTWFCSAYITNTNLSYANFSKVVLEKCELWENRWMGAQVLGATFSGSDLSGGEFST
                     FDWRAANFTHCDLTNSELGDLDIRRVDLQGVKLDNYQASLLMERLGIAIIG"
                     /name="quinolone resistance pentapeptide repeat protein
                     QnrB2"
     gene            complement(9365..>9571)
                     /locus_tag="JW293_RS02015"
                     /old_locus_tag="JW293_02015"
                     /pseudo=""
     CDS             complement(9365..>9571)
                     /locus_tag="JW293_RS02015"
                     /old_locus_tag="JW293_02015"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003833280.1"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /name="helix-turn-helix domain-containing protein"
     gene            <9563..9766
                     /locus_tag="JW293_RS02020"
                     /old_locus_tag="JW293_02020"
                     /pseudo=""
     CDS             <9563..9766
                     /locus_tag="JW293_RS02020"
                     /old_locus_tag="JW293_02020"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000679427.1"
                     /GO_component="GO:0016020 - membrane [Evidence IEA];
                     GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="SMR family transporter"
                     /name="SMR family transporter"
     gene            9760..10599
                     /gene="sul1"
                     /locus_tag="JW293_RS02025"
                     /old_locus_tag="JW293_02025"
     CDS             9760..10599
                     /gene="sul1"
                     /locus_tag="JW293_RS02025"
                     /old_locus_tag="JW293_02025"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000259031.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="sulfonamide-resistant dihydropteroate synthase
                     Sul1"
                     /protein_id="WP_000259031.1"
                     /translation="MVTVFGILNLTEDSFFDESRRLDPAGAVTAAIEMLRVGSDVVDVG
                     PAASHPDARPVSPADEIRRIAPLLDALSDQMHRVSIDSFQPETQRYALKRGVGYLNDIQ
                     GFPDPALYPDIAEADCRLVVMHSAQRDGIATRTGHLRPEDALDEIVRFFEARVSALRRS
                     GVAADRLILDPGMGFFLSPAPETSLHVLSNLQKLKSALGLPLLVSVSRKSFLGATVGLP
                     VKDLGPASLAAELHAIGNGADYVRTHAPGDLRSAITFSETLAKFRSRDARDRGLDHA"
                     /name="sul1"
     gene            11004..12545
                     /locus_tag="JW293_RS02030"
                     /old_locus_tag="JW293_02030"
     CDS             11004..12545
                     /locus_tag="JW293_RS02030"
                     /old_locus_tag="JW293_02030"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000050481.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS91-like element ISCR1 family transposase"
                     /protein_id="WP_000050481.1"
                     /translation="MSLARNATASQSPTQTNGYERHQPDQTLLYQLVEQHYPAFKASLE
                     AQGQHLPRYIQQEFNDLLQCGRLEYGFMRVRCEDCHHERLVAFSCKRRGFCPSCGARRM
                     AESAALLIDEVFPKEPIRQWVLSFPFQLRFLLARHPQLMGQVLSIVYRTLSTHLIKKAG
                     YTKASAQTGSVTLIQRFGSALNLNVHYHMLFLDGVYAEDDYGKQRFHRVKAPTYDELNT
                     LAHTLSHRIARCMEKRGILERDAENTWLTLEEGEDDTLTQLHGASVTYRIAVGPQQGRK
                     VFTLQTLPGREDKADSSSRVANHAGFSLHAGVMAEAHQRDKLERLCRYISRPAVSEKRL
                     ALTANGQVRYELKTPYRNGTTHVIFEPLDFIAKLAALVPKPRVNLTRFHGVFAPNSKHR
                     VQVTPAKRGKKPDKSEGLDTNWRDKSPAERHRAMTWMQRLKRVFNIDIEVCEHCGGHVK
                     VIASIEDPKVIEQILKHLKQKTAKANAAKQRELPPERAPPLTPSLFDPSQSRLFD"
                     /name="IS91-like element ISCR1 family transposase"
     gene            12809..13465
                     /locus_tag="JW293_RS02035"
                     /old_locus_tag="JW293_02035"
     CDS             12809..13465
                     /locus_tag="JW293_RS02035"
                     /old_locus_tag="JW293_02035"
                     /function="confers resistance to quinolones"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_024266192.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="quinolone resistance pentapeptide repeat protein
                     QnrA1"
                     /protein_id="WP_012579084.1"
                     /translation="MDIIDKVFQQEDFSRQDLSDSRFRRCRFYQCDFSHCQLQDASFED
                     CSFIESGAVEGCHFSYADLRDASFKACRLSLANFSGANCFGIEFRECDLKGANFSRARF
                     YNQVSHKMYFCSAYISGCNLAYTNLSGQCLEKCELFENNWSNANLSGASLMGSDLSRGT
                     FSRDCWQQVNLRGCDLTFADLDGLDPRRVNLEGVKICAWQQEQLLEPLGVIVLPD"
                     /name="quinolone resistance pentapeptide repeat protein
                     QnrA1"
     gene            13651..14526
                     /gene="ampR"
                     /locus_tag="JW293_RS02040"
                     /old_locus_tag="JW293_02040"
     CDS             13651..14526
                     /gene="ampR"
                     /locus_tag="JW293_RS02040"
                     /old_locus_tag="JW293_02040"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004236384.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator AmpR"
                     /protein_id="WP_004193231.1"
                     /translation="MVRRYLPLNPLRAFEAAARHLSFTRAAIELNVTHAAVSQQVRALE
                     EQLGCVLFTRVSRGLVLTHEGEGLLPVLNEAFDRIADTLECFSHGQFRERVKVGAVGTF
                     AAGWLLPRLAGFYDSHPHIDLHISTHNNHVDPAAEGHDYTIRFGNGAWHESDAELIFSA
                     PHAPLCSPAIAEQLQQPDDVHRFTLLRSFRRDEWSRWLDCAGGTPPSPSQPVMVFDTSL
                     AMAEAAQLGAGVAIAPVCMFSRLLQSGALVQPFAAEITLGGYWLTRLQSRTETPAMQQF
                     ARWLLNTAAA"
                     /name="ampR"
     gene            complement(14530..14895)
                     /gene="hypA"
                     /locus_tag="JW293_RS02045"
                     /old_locus_tag="JW293_02045"
     CDS             complement(14530..14895)
                     /gene="hypA"
                     /locus_tag="JW293_RS02045"
                     /old_locus_tag="JW293_02045"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004193196.1"
                     /GO_function="GO:0008901 - ferredoxin hydrogenase activity
                     [Evidence IEA]"
                     /GO_process="GO:0036211 - protein modification process
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydrogenase maturation nickel metallochaperone
                     HypA"
                     /protein_id="WP_025999322.1"
                     /translation="MTDYDNGGRGKLSKALGAADIIREQAEQHGIARVTDVWLEVGALA
                     DVEESALHFCFDIACRDTVAQGCTLHIDVIPAQAWCWDCSREAEIMQHAGCCPHCGSER
                     LRISEGDDLRVKSLEGE"
                     /name="hypA"
     gene            14788..15123
                     /locus_tag="JW293_RS02050"
                     /old_locus_tag="JW293_02050"
     CDS             14788..15123
                     /locus_tag="JW293_RS02050"
                     /old_locus_tag="JW293_02050"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000679428.1"
                     /GO_component="GO:0016020 - membrane [Evidence IEA];
                     GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SMR family transporter"
                     /protein_id="WP_052238321.1"
                     /translation="MRYPRNAVLFSLFADNVRRTEGFTKLAPSAVVIIGYGIAFYFLSL
                     VLKSIPVGVAYAVWSGLGVVIITAIAWLLHGQKLDAWGFVGMGLIIAAFLLARSPSWKS
                     LRRPTPW"
                     /name="SMR family transporter"
     ARG             20475..21310
                     /name="sul1"
                     /gene="sul1"
                     /gene_name="sulfonamide-resistant dihydropteroate synthase
                     Sul1"
                     /tool="amrfinderplus"
                     /drug_class="SULFONAMIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             15118..15953
                     /name="sul1"
                     /gene="sul1"
                     /gene_name="sulfonamide-resistant dihydropteroate synthase
                     Sul1"
                     /tool="amrfinderplus"
                     /drug_class="SULFONAMIDE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            16361..17902
                     /locus_tag="JW293_RS02060"
                     /old_locus_tag="JW293_02060"
     CDS             16361..17902
                     /locus_tag="JW293_RS02060"
                     /old_locus_tag="JW293_02060"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000050481.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS91-like element ISCR1 family transposase"
                     /protein_id="WP_000050481.1"
                     /translation="MSLARNATASQSPTQTNGYERHQPDQTLLYQLVEQHYPAFKASLE
                     AQGQHLPRYIQQEFNDLLQCGRLEYGFMRVRCEDCHHERLVAFSCKRRGFCPSCGARRM
                     AESAALLIDEVFPKEPIRQWVLSFPFQLRFLLARHPQLMGQVLSIVYRTLSTHLIKKAG
                     YTKASAQTGSVTLIQRFGSALNLNVHYHMLFLDGVYAEDDYGKQRFHRVKAPTYDELNT
                     LAHTLSHRIARCMEKRGILERDAENTWLTLEEGEDDTLTQLHGASVTYRIAVGPQQGRK
                     VFTLQTLPGREDKADSSSRVANHAGFSLHAGVMAEAHQRDKLERLCRYISRPAVSEKRL
                     ALTANGQVRYELKTPYRNGTTHVIFEPLDFIAKLAALVPKPRVNLTRFHGVFAPNSKHR
                     VQVTPAKRGKKPDKSEGLDTNWRDKSPAERHRAMTWMQRLKRVFNIDIEVCEHCGGHVK
                     VIASIEDPKVIEQILKHLKQKTAKANAAKQRELPPERAPPLTPSLFDPSQSRLFD"
                     /name="IS91-like element ISCR1 family transposase"
     gene            18166..18822
                     /locus_tag="JW293_RS02065"
                     /old_locus_tag="JW293_02065"
     CDS             18166..18822
                     /locus_tag="JW293_RS02065"
                     /old_locus_tag="JW293_02065"
                     /function="confers resistance to quinolones"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_024266192.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="quinolone resistance pentapeptide repeat protein
                     QnrA1"
                     /protein_id="WP_012579084.1"
                     /translation="MDIIDKVFQQEDFSRQDLSDSRFRRCRFYQCDFSHCQLQDASFED
                     CSFIESGAVEGCHFSYADLRDASFKACRLSLANFSGANCFGIEFRECDLKGANFSRARF
                     YNQVSHKMYFCSAYISGCNLAYTNLSGQCLEKCELFENNWSNANLSGASLMGSDLSRGT
                     FSRDCWQQVNLRGCDLTFADLDGLDPRRVNLEGVKICAWQQEQLLEPLGVIVLPD"
                     /name="quinolone resistance pentapeptide repeat protein
                     QnrA1"
     gene            19008..19883
                     /gene="ampR"
                     /locus_tag="JW293_RS02070"
                     /old_locus_tag="JW293_02070"
     CDS             19008..19883
                     /gene="ampR"
                     /locus_tag="JW293_RS02070"
                     /old_locus_tag="JW293_02070"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004236384.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="LysR family transcriptional regulator AmpR"
                     /protein_id="WP_004193231.1"
                     /translation="MVRRYLPLNPLRAFEAAARHLSFTRAAIELNVTHAAVSQQVRALE
                     EQLGCVLFTRVSRGLVLTHEGEGLLPVLNEAFDRIADTLECFSHGQFRERVKVGAVGTF
                     AAGWLLPRLAGFYDSHPHIDLHISTHNNHVDPAAEGHDYTIRFGNGAWHESDAELIFSA
                     PHAPLCSPAIAEQLQQPDDVHRFTLLRSFRRDEWSRWLDCAGGTPPSPSQPVMVFDTSL
                     AMAEAAQLGAGVAIAPVCMFSRLLQSGALVQPFAAEITLGGYWLTRLQSRTETPAMQQF
                     ARWLLNTAAA"
                     /name="ampR"
     gene            complement(19887..20252)
                     /gene="hypA"
                     /locus_tag="JW293_RS02075"
                     /old_locus_tag="JW293_02075"
     CDS             complement(19887..20252)
                     /gene="hypA"
                     /locus_tag="JW293_RS02075"
                     /old_locus_tag="JW293_02075"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004193196.1"
                     /GO_function="GO:0008901 - ferredoxin hydrogenase activity
                     [Evidence IEA]"
                     /GO_process="GO:0036211 - protein modification process
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hydrogenase maturation nickel metallochaperone
                     HypA"
                     /protein_id="WP_025999322.1"
                     /translation="MTDYDNGGRGKLSKALGAADIIREQAEQHGIARVTDVWLEVGALA
                     DVEESALHFCFDIACRDTVAQGCTLHIDVIPAQAWCWDCSREAEIMQHAGCCPHCGSER
                     LRISEGDDLRVKSLEGE"
                     /name="hypA"
     gene            20145..20480
                     /locus_tag="JW293_RS02080"
                     /old_locus_tag="JW293_02080"
     CDS             20145..20480
                     /locus_tag="JW293_RS02080"
                     /old_locus_tag="JW293_02080"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000679428.1"
                     /GO_component="GO:0016020 - membrane [Evidence IEA];
                     GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="SMR family transporter"
                     /protein_id="WP_052238321.1"
                     /translation="MRYPRNAVLFSLFADNVRRTEGFTKLAPSAVVIIGYGIAFYFLSL
                     VLKSIPVGVAYAVWSGLGVVIITAIAWLLHGQKLDAWGFVGMGLIIAAFLLARSPSWKS
                     LRRPTPW"
                     /name="SMR family transporter"
     ARG             9761..10596
                     /name="sul1"
                     /gene="sul1"
                     /gene_name="sulfonamide-resistant dihydropteroate synthase
                     Sul1"
                     /tool="amrfinderplus"
                     /drug_class="SULFONAMIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             426..1261
                     /name="sul1"
                     /gene="sul1"
                     /gene_name="sulfonamide-resistant dihydropteroate synthase
                     Sul1"
                     /tool="amrfinderplus"
                     /drug_class="SULFONAMIDE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            21441..21941
                     /locus_tag="JW293_RS02090"
                     /old_locus_tag="JW293_02090"
     CDS             21441..21941
                     /locus_tag="JW293_RS02090"
                     /old_locus_tag="JW293_02090"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004194535.1"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_000376623.1"
                     /translation="MDSEEPPNVRVACSGDIDEVVRLMHDAAAWMSAKGTPAWDVARID
                     RTFAETFVLRSELLVASCSDGIVGCCTLSAEDPEFWPDALKGEAAYLHKLAVRRTHAGR
                     GVSSALIEACRHAARTQGCAKLRLDCHPNLRGLYERLGFTHVDTFNPGWDPTFIAERLE
                     LEI"
                     /name="GNAT family N-acetyltransferase"
     gene            <22262..22330
                     /locus_tag="JW293_RS02095"
                     /old_locus_tag="JW293_02095"
                     /pseudo=""
     CDS             <22262..22330
                     /locus_tag="JW293_RS02095"
                     /old_locus_tag="JW293_02095"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_005229646.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="EAL domain-containing protein"
                     /name="EAL domain-containing protein"
     gene            22448..23212
                     /locus_tag="JW293_RS02100"
                     /old_locus_tag="JW293_02100"
     CDS             22448..23212
                     /locus_tag="JW293_RS02100"
                     /old_locus_tag="JW293_02100"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001389365.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS6100 family transposase"
                     /protein_id="WP_001389365.1"
                     /translation="MTDFKWRHFQGDVILWAVRWYCRYPISYRDLEEMLAERGISVDHT
                     TIYRWVQCYAPEMEKRLRWFWRRGFDPSWRLDETYVKVRGKWTYLYRAVDKRGDTIDFY
                     LSPTRSAKAAKRFLGKALRGLKHWEKPATLNTDKAPSYGAAITELKREGKLDRETAHRQ
                     VKYLNNVIEADHGKLKILIKPVRGFKSIPTAYATIKGFEVMRALRKGQARPWCLQPGIR
                     GEVRLVERAFGIGPSALTEAMGMLNHHFAAAA"
                     /name="IS6-like element IS6100 family transposase"
     gene            <23267..23533
                     /locus_tag="JW293_RS02105"
                     /old_locus_tag="JW293_02105"
                     /pseudo=""
     CDS             <23267..23533
                     /locus_tag="JW293_RS02105"
                     /old_locus_tag="JW293_02105"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001389365.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="DDE-type integrase/transposase/recombinase"
                     /name="DDE-type integrase/transposase/recombinase"
     gene            complement(23673..>23738)
                     /locus_tag="JW293_RS02110"
                     /old_locus_tag="JW293_02110"
                     /pseudo=""
     CDS             complement(23673..>23738)
                     /locus_tag="JW293_RS02110"
                     /old_locus_tag="JW293_02110"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_005229646.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="EAL domain-containing protein"
                     /name="EAL domain-containing protein"
     gene            complement(23771..23983)
                     /locus_tag="JW293_RS02115"
                     /old_locus_tag="JW293_02115"
     CDS             complement(23771..23983)
                     /locus_tag="JW293_RS02115"
                     /old_locus_tag="JW293_02115"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000993245.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3330 domain-containing protein"
                     /protein_id="WP_000993245.1"
                     /translation="MNANAPNTASCTTCCVCCKEIPLDAAFTPEGAEYVEHFCGLDCYE
                     RFQARAKAATESDIAPVPGGSQPSD"
                     /name="DUF3330 domain-containing protein"
     gene            complement(24049..24285)
                     /gene="merE"
                     /locus_tag="JW293_RS02120"
                     /old_locus_tag="JW293_02120"
     ARG             complement(24053..24285)
                     /name="merE"
                     /gene="merE"
                     /gene_name="broad-spectrum mercury transporter MerE"
                     /tool="amrfinderplus"
                     /drug_class="MERCURY"
                     /identity="96.15"
                     /coverage="100.0"
     gene            complement(24282..24648)
                     /gene="merD"
                     /locus_tag="JW293_RS02125"
                     /old_locus_tag="JW293_02125"
                     /pseudo=""
     CDS             complement(24282..24648)
                     /gene="merD"
                     /locus_tag="JW293_RS02125"
                     /old_locus_tag="JW293_02125"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001277466.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]; GO:0006355 -
                     regulation of DNA-templated transcription [Evidence IEA]"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="mercury resistance co-regulator MerD"
                     /name="merD"
     gene            complement(24614..>25438)
                     /locus_tag="JW293_RS25785"
                     /pseudo=""
     CDS             complement(24614..>25438)
                     /locus_tag="JW293_RS25785"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003098932.1"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="FAD-dependent oxidoreductase"
                     /name="FAD-dependent oxidoreductase"
     ARG             12810..13462
                     /name="qnrA1"
                     /gene="qnrA1"
                     /gene_name="quinolone resistance pentapeptide repeat
                     protein QnrA1"
                     /tool="amrfinderplus"
                     /drug_class="QUINOLONE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             18167..18819
                     /name="qnrA1"
                     /gene="qnrA1"
                     /gene_name="quinolone resistance pentapeptide repeat
                     protein QnrA1"
                     /tool="amrfinderplus"
                     /drug_class="QUINOLONE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             complement(8629..9269)
                     /name="qnrB2"
                     /gene="qnrB2"
                     /gene_name="quinolone resistance pentapeptide repeat
                     protein QnrB2"
                     /tool="amrfinderplus"
                     /drug_class="QUINOLONE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             complement(6579..7480)
                     /name="mph(A)"
                     /gene="mph(A)"
                     /gene_name="Mph(A) family macrolide 2'-phosphotransferase"
                     /tool="amrfinderplus"
                     /drug_class="MACROLIDE"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             complement(6576..7480)
                     /name="mphA"
                     /gene="mphA"
                     /gene_name="macrolide phosphotransferase (MPH)"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             complement(8626..9269)
                     /name="QnrB20"
                     /gene="QnrB20"
                     /gene_name="quinolone resistance protein (qnr)"
                     /tool="rgi"
                     /drug_class="fluoroquinolone antibiotic"
                     /identity="99.53"
                     /coverage="94.69"
     ARG             complement(5341..6578)
                     /name="Mrx"
                     /gene="Mrx"
                     /gene_name="macrolide phosphotransferase (MPH)"
                     /tool="rgi"
                     /drug_class="macrolide antibiotic"
                     /identity="100.0"
                     /coverage="100.0"
ORIGIN
        1 ccaggcctca gcattttatt atggtgatcc cctgggcgaa atgcgcctgg taagcagagt
       61 ttttgaaatg taaggccttt gaataagaca aaaggctgcc tcatcgctaa ctttgcaaca
      121 gtgccgtaat cgcaacatcc gcattaaaat ctagcgaggg ctttactaag cttgcccctt
      181 ccgccgttgt cataatcggt tatggcatcg cattttattt tctttctctg gttctgaaat
      241 ccatccctgt cggtgttgct tatgcagtct ggtcgggact cggcgtcgtc ataattacag
      301 ccattgcctg gttgcttcat gggcaaaagc ttgatgcgtg gggctttgta ggtatggggc
      361 tcataattgc tgcctttttg ctcgcccgat ccccatcgtg gaagtcgctg cggaggccga
      421 cgccatggtg acggtgttcg gcattctgaa tctcaccgag gactccttct tcgatgagag
      481 ccggcggcta gaccccgccg gcgctgtcac cgcggcgatc gaaatgctgc gagtcggatc
      541 agacgtcgtg gatgtcggac cggccgccag ccatccggac gcgaggcctg tatcgccggc
      601 cgatgagatc agacgtattg cgccgctctt agacgccctg tccgatcaga tgcaccgtgt
      661 ttcaatcgac agcttccaac cggaaaccca gcgctatgcg ctcaagcgcg gcgtgggcta
      721 cctgaacgat atccaaggat ttcctgaccc tgcgctctat cccgatattg ctgaggcgga
      781 ctgcaggctg gtggttatgc actcagcgca gcgggatggc atcgccaccc gcaccggtca
      841 ccttcgaccc gaagacgcgc tcgacgagat tgtgcggttc ttcgaggcgc gggtttccgc
      901 cttgcgacgg agcggggtcg ctgccgaccg gctcatcctc gatccgggga tgggattttt
      961 cttgagcccc gcaccggaaa catcgctgca cgtgctgtcg aaccttcaaa agctgaagtc
     1021 ggcgttgggg cttccgctat tggtctcggt gtcgcggaaa tccttcttgg gcgccaccgt
     1081 tggccttcct gtaaaggatc tgggtccagc gagccttgcg gcggaacttc acgcgatcgg
     1141 caatggcgct gactacgtcc gcacccacgc gcctggagat ctgcgaagcg caatcacctt
     1201 ctcggaaacc ctcgcgaaat ttcgcagtcg cgacgccaga gaccgagggt tagatcatgc
     1261 ctagcattca ccttccggcc gcccgctagc ggaccctggt caggttccgc gaaggtgggc
     1321 gcagacatgc tgggctcgtc aggatcaaac tgcactatga ggcggcggtt cataccgcgc
     1381 caggggagcg aatggacagc gaggagcctc cgaacgttcg ggtcgcctgc tcgggtgata
     1441 tcgacgaggt tgtgcggctg atgcacgacg ctgcggcgtg gatgtccgcc aagggaacgc
     1501 ccgcctggga cgtcgcgcgg atcgaccgga cattcgcgga gaccttcgtc ctgagatccg
     1561 agctcctagg gatcgcctca gaaaacggaa aataaagcac gctaagccgt aagtaagcgt
     1621 gctcctgtga aagccacagc taaaactgcg tagtacacat agaggtattt ttttctagat
     1681 ttatatcgaa tttcgttatc gaatttcgct tattattgat caactcgttg cagatcatga
     1741 aggcgaaagt atgacgaata accctaccga tgacagcaga ccatggtcgg tctttcttat
     1801 ttttctgcgg cttggattga catcttttgg cggccccatt gcgcacttgg gctacttccg
     1861 cgccgaattt gtcacacggc ggcgctggct ctccgaacgg agctatgctg acttggtcgc
     1921 gctttgtcag ttcttgccag ggcctgcaag cagccaggtc ggcatagcgg taggactgtc
     1981 tcgggctgga tacagcgggg cgctggctgc ttgggctggc ttcacgctgc cgtctgccat
     2041 agccttgatc ctttttgcgc tcggcatctc cagctatggc gattacgtct cgcagggcgc
     2101 gttgcatggc ttaaaagtgg tggctgtggc cgtggtcgct caagcagtat ggggcatggc
     2161 gcgtaaccta tgcacggatg ggctgcgagt caccatcatg gcaattgcta cctgcgtcgt
     2221 tttacttgtg ccgtccgcgt ggggacaggt tggcgtgatt gctatcgcag gcatcgcagg
     2281 ccggttattg ttcaagccag cgaaagttgt tgagcatgac cccctaccta tcacggtcag
     2341 tcaccgggcc ggcgtgcttt ggctctcgct gttctttgtc ttgctgattg gcctgccggt
     2401 gttggccgaa ctgatgccaa gtcaaaccat ggcaatggtg gattccttct atcgtgtcgg
     2461 atcactggtg ttcggcggtg gtcacgttgt gctgccatta ctgcaagccg aagtggtgcc
     2521 ctccggctgg gtcaacaatg aatcctttct cgcggggtac ggggcagctc aagcggtgcc
     2581 cggccctttg ttcacgttcg ccgcgtttct tggtgcctcg atgaacaccg ccccgtcggg
     2641 ctggatcggc ggcattgtgt gtctgctggc tatcttcgcg ccctcgttct tgctggtcgt
     2701 cggatcaatg ccattttggg agcgtttgcg ccgcaataca ggcatccaag ctgcgctggc
     2761 cgggatcaat gccgctgtag tcggcttgct gctggccgcg ctgtatcagc ctgtatggac
     2821 tagcgccatc tttcagccgc aagacttcgg cttggcatta gttgcccttg tcgcacttat
     2881 gttctggaag ctcccgccgt ggctggttgt cctcggtagc ggtgcagctg ggtggctgtt
     2941 gagcgtcgct ctgtgaggca caaaaaatga ctgacaaaga cctctacggc ggtttgatcc
     3001 gcctgcacat ccttcaccat gcagccgagg aacctgtctt tgggctgggg atcatcgaag
     3061 agctacgccg acacggctac gagatgagcg ctggcaccgt gtacccgatg ctgcacggcc
     3121 tggaaaaaaa aggctatctg acctcacgcc acgaacgcac cgggcgacgt gaacggcgtg
     3181 tttatgacat cactgaacaa ggcagaactg cacttgctga tgcgaaaaca aaggtcaagg
     3241 agctgttcgg agagttggta gaaggtggtt gagtttttgc ttctatgtca ggttgagcta
     3301 taccctaact ggattgtcat tttcagaaga cgactgcacc agttgattgg gcgtaatggc
     3361 tgttgtgcag ccagctcctg acagttcaat atcagaagtg atctgcacca atctcgacta
     3421 tgctcaatac tcgtgtgggc tctgttgcaa aaatcgtgaa gcttgagcat gcttggcgga
     3481 gattggacgg acggaacgat gacggatttc aagtggcgcc atttccaggg tgatgtgatc
     3541 ctgtgggcgg tgcgctggta ttgtcgctat ccgatcagct atcgcgacct tgaggaaatg
     3601 ctggcggaac gcggcatttc ggtcgaccat acgacgatct atcgctgggt ccagtgctac
     3661 gccccggaga tggagaagcg gctgcgctgg ttctggcggc gtggctttga tccgagctgg
     3721 cgcctggatg aaacctacgt caaggtgcgg ggcaagtgga cctacctgta ccgggcagtc
     3781 gacaagcggg gcgacacgat cgatttctac ctgtcgccga cccgcagcgc caaggcagcg
     3841 aagcggttcc tgggcaaggc cctgcgaggc ctgaagcact gggaaaagcc tgccacgctc
     3901 aataccgaca aagcgccgag ctatggtgca gcgatcaccg aattgaagcg cgaaggaaag
     3961 ctggaccggg agacggccca ccggcaggtg aagtatctca ataacgtgat cgaggccgat
     4021 cacggaaagc tcaagatact gatcaagccg gtgcgcggtt tcaaatcgat ccccacggcc
     4081 tatgccacga tcaagggatt cgaagtcatg cgagccctgc gcaaaggaca ggctcgcccc
     4141 tggtgcctgc agcccggcat caggggcgag gtgcgccttg tggagagagc ttttggcatt
     4201 gggccctcgg cgctgacgga ggccatgggc atgctcaacc accatttcgc agcagccgcc
     4261 tgatcggcgc agagcgacag cctacctctg actgccgcca atctttgcaa cagagcccgc
     4321 cgtgctagtc tgctcggtga tggtggagtg aagccaaccc gcaatcgggt tatgaatctg
     4381 catcgcgatt cgcaatcagc tgtctcttga gcatgtcgaa ctcctgcgat gttatctcgc
     4441 cgtgctcgtg ctgctacacc aacttgtcca actcatccgc cacaccgctc cccaccacct
     4501 gcgatggcca ggttgtttgc tgggcgcatt ggcggagtat cgtctcgacc cgggacaccc
     4561 acaccggcac aaccttacgg gagtgattca ctgtcaaaga atcggcccgg tgctctgacg
     4621 caagtatcgg gatggtcacc atttgtaagc cgtagacctg agtggtgatc aagacttcga
     4681 taccaccgac cgtaccggta ctaatcgacg acggtcgtgt tcgtcgcctg ccgcagggac
     4741 tctgcacacc tccgtttacg catgtgcctg gaggagttgg aaatcgtcgt gttcgggaaa
     4801 cattaaacac aggatggcag cgatctgagc cagcacatga tcagctagct caccatccgg
     4861 atcgacggcc cactgcatcg tcgcgccagc gatgaccgag tgcaggagca actcagctgc
     4921 cgcaggagca cctgggggca gtcgcttgcg gatcccctcc accaccgcgc ggttccgctg
     4981 gatcgcaagc gtgcgtagct ccggcacctg gagctcgtac caggagatga gatagttcac
     5041 cgagaagtcg ttgcgagtgt tcatgctccg aacgagcacc tgcaaaaatt cccagagccc
     5101 ttgcggccct gcgcctatcg gtatcgcatt caggtaatgc cgcacctgct cgacgccgcg
     5161 ctccatcatc ctcaccagca gcgtatcgcg gttggtgaag cgctggatta acgctgcgcg
     5221 ggagagcccc acctcctttg ctactccgct gagcgtgaac tctatgggac cgcaacgctt
     5281 cagcactacg gtggcggcct cgagtacctc gtcatcggac ttgagcttgg ggcggggcat
     5341 cagtgttcac cttctgtatg ggttggggcg gaggctgtgg ctgccgccgc cattgtagca
     5401 aattgaagac ggagcgagag tagagccacg agccccgcaa acacggccga tacaacgagg
     5461 ccagggagcg gaccagcaag gtcgacaaac gcgccggccg caagcataac catgggcgag
     5521 gctgacagca tcaccgccga gaccgtgccg agtacccggc cgagaagttc tggcggcgtg
     5581 cggttgtaga tggcagcgtt gagaatggga gagactgagc cggtcagcag tcccacgagc
     5641 gcgcccaaca acatcagcac cggcacgcct ggcaactgtg aaagcagaag cgagcccacc
     5701 gcagagccac aaaatgccac cgccagccag ttctgcgctg atatccgggc gccgaccgac
     5761 gcatgaatgg caatgccaag gagaccacca gcccccatca ttgaggagaa cagcccgagc
     5821 tctgctactt ggcgtcctgc atctacaaac agcgcaggca tgatgacgct gccgttggcg
     5881 ccaacgatgc ccacgaagat catcactata ccaaagagag ggcgcagcag gggttcgctc
     5941 cagagaaaag cgacgccggc gcgcatggag agagtcgccg tcgtggtcat cgtccgagcg
     6001 gcacgcgcgg gaagcaccca cgcgccgagc agacctgcaa ggacggagca gaacgccgtc
     6061 agcccgagcg ttggcgcagc gccaagcagg ccgattgcgg cccccccaag ggccgggcca
     6121 cctagaatcg cgacgttccc gatcaccgct ttcagtgacg agacgcgctc aacggagagc
     6181 ccggcgacgt ggccgagttt gggcagctca ctgtcctgcg cggccatacc gggtgcgtcg
     6241 aacgcggcac cgagcaccac gcaagcgatc agcccagtgt tcgagagggc gccaacggca
     6301 tcgagcagtg ggatgctcgc catggccacg ccgcccacca cacccgagat caatgcgacg
     6361 ggcgcgcgcc cgaaccgatc gacgaggcca ccaccaaccc acgcgccgat gatggtcgcg
     6421 atgacgctgc tagcggccgt ggcgcccgcc caggccgcgc tctttgtatg agacaggacg
     6481 aaccatggaa gcgcgagggc cgccaccgcg ttgccgatcc ggaagagaaa ggtcgccgcg
     6541 aacagcgtcg cgagcgggct atatcgacgt tcgctcattc cgctgcggcg agctgcgcct
     6601 tcgccgcagc gaggtactct tcgttacccg agtcgagggc gaagagtgcg taggtgaccg
     6661 ccccgaacgc aaggcgctcc gcgatgtggt gggcgagccg cggccacacc cggccaccgg
     6721 ccgcttcata cgtgaggagg agcttcgcga gcccctcttc accaaagacc ataaggtgcg
     6781 cggccatgtc gatggcaggg tcatcaacgc gggcctcgct ccagtcgatc atcccgctga
     6841 cgcgctccgt gttgtcgatg agcacatggc ccacgtagag atcgccatgc accaccacgg
     6901 agaaatctgg ccacgacgaa tcgtcgtcga gccagcgctg ccaccggtgg aggcgcttgt
     6961 cgttcaccac gaactcgcgt cggacgcggt caacgtcgtc ggccaccttc tgacgggcct
     7021 gcgtcggtgt acggatgagc atccccgcat ccacggcggc ggaaatgggg acggcatgca
     7081 gggcggcgag cgcggtcgcg aagctctccg cgaagacctc cgagtcctgc ggcacgaccc
     7141 agtcgggcgt ggacgaacca ggctggatga ccatcgcagt cgagtcttcg agcatgggat
     7201 aggcaacgag ctcggcgttg gccacgcgcc agtccggcac cgcgaacggc aggcgattct
     7261 tgagcattgc cagcacccgc gcctctggtt cgaccttcgc gcttacctcg gctcggcgcg
     7321 ggatgcgcag cacccaccga cgtccatcgt cgacggtggc gatcacgatc ctatagtcga
     7381 gcccaagctc attgacagtc agcgggccat ggagcttgag cccatgtcgg gctgcaagtg
     7441 cgtacagttg ggaggtatcg gcggtcgtga ctacggtcat gattcactcc tgagggcttg
     7501 acgggtttag ccacctaaat gtaacagtca cgtcggttat attcaatccg gcactgttgc
     7561 aaagttagcg atgaggcagc cttttgtctt attcaaaggc cttacatttc aaaaactctg
     7621 cttaccaggc gcatttcgcc caggggatca ccataataaa atgctgaggc ctggcctttg
     7681 cgtagtgcac gcatcacctc aatacctttg atggtggcgt aagccgtctt catggattta
     7741 aatcccagcg tggcgccgat tatccgtttc agtttgccat gatcgcattc aatcacgttg
     7801 ttccggtact taatctgtcg gtgttcaacg tcagacgggc accggccttc gcgtttgagc
     7861 agagcaagcg cgcgaccata ggcgggcgct ttatccgtgt tgatgaatcg cgggatctgc
     7921 cacttcttca cgttgttgag gattttaccc agaaaccggt atgcagcttt gctgttacga
     7981 cgggaggaga tataaaaatc gacagtgcgg ccccggctgt cgacggcccg gtacagatac
     8041 gcccagcggc cattgacctt cacgtaggtt tcatccatgt gccacgggca aagatcggaa
     8101 gggttacgcc agtaccagcg cagccgtttt tccatttcag gcgcataacg ctgaacccag
     8161 cggtaaatcg tggagtgatc gacattcact ccgcgttcag ccagcatctc ctgcagctca
     8221 cggtaactga tgccgtattt gcagtaccag cgtacggccc acagaatgat gtcacgctga
     8281 aaatgccggc ctttgaatgg gttcatgtgc agctccatca gcaaaagggg atgataagtt
     8341 tatcaccacc gactatttgc aacagtgcct tatttcgagc attttcttgc gaaaaagccg
     8401 accgggaaaa ttgacatgcg taccattcgc ctggggtgta ataaggcgat agacaccggt
     8461 acctacacat ttaccttcgc ggacaaatca acggtttcag cccgctacac attcacttat
     8521 gcatgggacg gtaaagagtg gaaaatttcc acacaccact cttcagcgat gcctgaaggg
     8581 taaaaagctg tgcagggggc ggaatattca ccgctccctg aagactagcc aataatcgcg
     8641 atgccaagac gttccatgag caacgatgcc tggtagttgt ccaacttaac gccttgtaaa
     8701 tcaacgcgcc gaatatctaa gtcacccaac tccgaattgg tcagatcgca atgtgtgaag
     8761 tttgctgctc gccagtcgaa agtcgaaaac tcgccgccgg agagatctga accactgaac
     8821 gtcgcgccca gtacctgggc ccccatccaa cggttttccc acagctcaca cttttccaac
     8881 acgactttcg aaaaattggc gtagcttaga tttgtgttag tgatatatgc actgcaaaac
     8941 caggtgcgag tagtgatcat attcataaaa cttgcgccgc gaaaatctgc gccttgcgca
     9001 cgacagtggc gaatttcaat gccaagcgca ctggcattgc gaaaatccgc catggataaa
     9061 tcacagcttt taaaaatggc atctttcagc atcgcacgac taaaattgca ccctttctgg
     9121 ctttcacgat catagaactg acagccgata aattcagtgc cgctcaggtc ggcacctgaa
     9181 aaatcacagt taaaaaatgt actattttca attttctcac cggtgaagcg gtttctgtta
     9241 attttttcgc caacgagtgc cagagccata ttttgtgcct gtttttttat acagtaatgg
     9301 cgtcatggta aaccctgatg aggttatgcg tcaaatccgc caatataaca tctgcaaatg
     9361 tgcgttaaat ctggtgtttt ttcagcaaag cgcgaagctg atggtaagtc agacccagta
     9421 attcagcggc ttttttctgg ttaaattttg cctgctgtaa gctggtttgt agaaagtctt
     9481 tctcttgctg ctgctggaat tcacgcagat ccagcggtaa ccctacagac atcggtttag
     9541 tttccggcgc ctgcggctgc gtctggttct gaaatccatc cctgtcggtg ttgcttatgc
     9601 agtctggtcg ggactcggcg tcgtcataat tacagccatt gcctggttgc ttcatgggca
     9661 aaagcttgat gcgtggggct ttgtaggtat ggggctcata attgctgcct ttttgctcgc
     9721 ccgatcccca tcgtggaagt cgctgcggag gccgacgcca tggtgacggt gttcggcatt
     9781 ctgaatctca ccgaggactc cttcttcgat gagagccggc ggctagaccc cgccggcgct
     9841 gtcaccgcgg cgatcgaaat gctgcgagtc ggatcagacg tcgtggatgt cggaccggcc
     9901 gccagccatc cggacgcgag gcctgtatcg ccggccgatg agatcagacg tattgcgccg
     9961 ctcttagacg ccctgtccga tcagatgcac cgtgtttcaa tcgacagctt ccaaccggaa
    10021 acccagcgct atgcgctcaa gcgcggcgtg ggctacctga acgatatcca aggatttcct
    10081 gaccctgcgc tctatcccga tattgctgag gcggactgca ggctggtggt tatgcactca
    10141 gcgcagcggg atggcatcgc cacccgcacc ggtcaccttc gacccgaaga cgcgctcgac
    10201 gagattgtgc ggttcttcga ggcgcgggtt tccgccttgc gacggagcgg ggtcgctgcc
    10261 gaccggctca tcctcgatcc ggggatggga tttttcttga gccccgcacc ggaaacatcg
    10321 ctgcacgtgc tgtcgaacct tcaaaagctg aagtcggcgt tggggcttcc gctattggtc
    10381 tcggtgtcgc ggaaatcctt cttgggcgcc accgttggcc ttcctgtaaa ggatctgggt
    10441 ccagcgagcc ttgcggcgga acttcacgcg atcggcaatg gcgctgacta cgtccgcacc
    10501 cacgcgcctg gagatctgcg aagcgcaatc accttctcgg aaaccctcgc gaaatttcgc
    10561 agtcgcgacg ccagagaccg agggttagat catgcctagc attcaccttc cggccgcccg
    10621 ctaaatatct ccttttgggt tgttaataaa acatccaata agttgactgt gcgtgaaaaa
    10681 gaaagttttg tgtgatggcg ttgaagatcg caccgttaag ctcttatgtg ggatggtgca
    10741 gagctcgacg actaccgata aaacgcaacc gccgcaaaca gacaagaaaa agccccaact
    10801 gataacagtt ggggcttcag tattgtgatt ggtggagcaa tagcaccctg aacccaaaac
    10861 cttctcgctc aaccggtagt ggctgataac aactcgtgag ggctattgcg ggttaagcat
    10921 ttagcgatgt ctagggccag actggacgtc tgaacgcaag ccgctgatac tgtacataac
    10981 cacagtatca gcggaggata cccatgtcgc tggcaaggaa cgccacggcg agtcaatcgc
    11041 ccactcaaac aaacggttac gaacgccacc aacccgacca gacgctgctc taccagctgg
    11101 ttgagcagca ctacccagcc ttcaaagcct cactcgaagc ccaaggtcaa cacctgcctc
    11161 gctacatcca acaagaattc aacgacctcc tccaatgtgg ccgtctggag tatggtttca
    11221 tgcgggttcg ctgcgaggat tgtcatcacg agcgtctggt cgccttcagc tgtaaacgac
    11281 gcggcttttg ccctagctgc ggtgcccgcc ggatggccga gagtgcggcg ctgctgatag
    11341 acgaagtctt ccccaaggag cccattcgcc agtgggtgct cagctttcct ttccagctac
    11401 gctttttgct ggctcgccat ccccagctga tgggccaggt cttgagtatc gtctatcgta
    11461 cactctcaac tcatctgatc aaaaaagccg gttacaccaa agcctctgca caaactggct
    11521 cagtgactct tatccaacgc tttggctccg cgctaaatct caatgtccac taccacatgc
    11581 tgtttctcga tggtgtctat gccgaagatg actatggcaa gcaacgcttc catcgtgtca
    11641 aggcacccac ttacgatgag ctgaatacgc tcgctcacac cctcagccat cgcatcgctc
    11701 gctgcatgga aaagcgtggg attttggagc gtgatgccga gaatacgtgg ttgacactgg
    11761 aagagggcga agacgatacg ctgactcaat tacatggtgc ttcggttacg tatcgcattg
    11821 ccgtcggccc ccagcaaggg cgcaaagtct tcaccctgca aaccttgcca gggcgtgagg
    11881 ataaagccga ctcaagcagt cgagtagcca accatgctgg tttctcgcta cacgccggtg
    11941 tgatggccga agcgcatcag cgggataagc ttgagcgctt gtgtcgctac attagtcggc
    12001 cagcggtttc agaaaaacgt ctggcattaa ccgccaatgg gcaggtgcgt tacgagctca
    12061 aaactccgta ccgcaatggc accacccatg tgatcttcga gccgctggac ttcatcgcca
    12121 aactcgctgc gttggtacct aagccgcgag tcaacctcac acgcttccac ggcgtctttg
    12181 caccgaacag caaacaccga gttcaagtaa cacccgccaa gcggggcaag aagcccgaca
    12241 aatcggaagg tctcgatact aactggcgtg acaagagtcc tgcagagcgc caccgcgcca
    12301 tgacctggat gcaacgcctc aagcgagtct tcaatattga tattgaagtc tgcgaacact
    12361 gcggcggtca cgtcaaagtg attgccagca tcgaagatcc gaaggtcatt gagcagattc
    12421 tcaagcatct gaaacagaaa acagccaagg cgaatgccgc caagcagcgt gagctgccac
    12481 cagaacgagc gccgccactg actcccagcc tgttcgatcc atcacagagt cgtctctttg
    12541 actgacgacc ccaaatccaa cactgctcaa cactgccaac ttttaaacgg ggcggtgggg
    12601 cagtttgtat ctctcgagct atcaggctag agattttacc gccaaatcga accttattag
    12661 agcggtttag gctggaccgg cagttaaaat tggggcttga gcggtaaacg agtgagggaa
    12721 tttcaggtaa gatacttcgg atgaggagca aaaaggtggt ttatacttcc tatacccgtt
    12781 agcaccctcc ctgattaaag gaagccgtat ggatattatt gataaagttt ttcagcaaga
    12841 ggatttctca cgccaggatt tgagtgacag ccgttttcgc cgctgccgct tttatcagtg
    12901 tgacttcagc cactgtcagc tgcaggatgc cagtttcgag gattgcagtt tcattgaaag
    12961 cggcgccgtt gaagggtgtc acttcagcta tgccgatctg cgcgatgcca gtttcaaggc
    13021 ctgccgtctg tctttggcca acttcagcgg tgccaactgc tttggcatag agttcaggga
    13081 gtgcgatctc aagggcgcca acttttcccg ggcccgcttc tacaatcaag tcagccataa
    13141 gatgtacttc tgctcggctt atatctcagg ttgcaacctg gcctatacca acttgagtgg
    13201 ccaatgcctg gaaaaatgcg agctgtttga aaacaactgg agcaatgcca atctcagcgg
    13261 cgcttccttg atgggctcag atctcagccg cggcaccttc tcccgcgact gttggcaaca
    13321 ggtcaatctg cggggctgtg acctgacctt tgccgatctg gatgggctcg accccagacg
    13381 ggtcaacctc gaaggagtca agatctgtgc ctggcaacag gagcaactgc tggaaccctt
    13441 gggagtaata gtgctgccgg attagctcga atgcaaacac aagaggcaaa tatcacttga
    13501 gttccgcgct acaacaaggc agattctgct atagcagagt attaccgccg gaatgccgtt
    13561 tctctgctgc cgcagccgac gttatacctt cccttcaaag gaggcattat gaagactcaa
    13621 ctgccctaaa gaaaaactta caggtggatt atggtcagac gttatctccc ccttaacccg
    13681 ctgcgcgcct ttgaggccgc cgcccgtcat ctcagtttta cccgcgcggc gattgagctg
    13741 aatgtcaccc atgccgccgt cagccagcag gtcagggcgc tggaagaaca actcggctgt
    13801 gtgctgttta cccgcgtctc gcgcgggctg gtgctgaccc atgaaggtga gggattactg
    13861 ccggtgctca atgaggcgtt tgaccggatt gcggatactc tggagtgttt ttctcacggg
    13921 cagttccgtg agcgggtgaa agtcggtgcg gtgggaacat ttgccgcagg ctggctgctg
    13981 ccgcgtctgg ccggattcta tgacagccat ccgcatattg atctgcatat ctccacccat
    14041 aacaatcatg tggacccggc ggcggaaggg catgattata cgatccgttt cggtaacggc
    14101 gcgtggcatg agtcagatgc ggaactgatt ttcagtgcac cacacgctcc gctgtgctca
    14161 ccggccattg cagaacagtt acagcagccg gatgatgttc accgctttac cctgctgcgc
    14221 tcattccgcc gggatgaatg gagccgctgg ctggattgtg cgggcggcac accgccttcc
    14281 ccgtcacagc cggtaatggt gttcgatacc tcactggcca tggccgaggc ggcacaactg
    14341 ggtgccgggg tagcgatcgc accggtatgt atgttcagcc gcctgttaca gtcaggcgca
    14401 ctggtacagc cgtttgccgc agaaatcacc ctcggcggct actggctgac gcggttacag
    14461 tcccgtacgg aaaccccggc catgcagcaa ttcgcccgct ggctgctgaa tacggcggcg
    14521 gcgtaaaact cactcacctt ccaggctttt tacccgcaaa tcatcacctt cactgatgcg
    14581 cagccgttca ctgccgcagt gcggacagca tccggcgtgc tgcatgattt cggcctcacg
    14641 gctgcaatcc cagcaccatg cctgtgccgg gataacatca atatgcagtg tgcagccctg
    14701 cgccacggta tcacggcagg cgatatcaaa acagaaatgc agtgcactct cctcaacatc
    14761 cgccagtgcg ccgacttcca gccagacatc cgttacccgc gcaatgccgt gctgttcagc
    14821 ctgttcgcgg ataatgtccg ccgcaccgag ggctttacta agcttgcccc ttccgccgtt
    14881 gtcataatcg gttatggcat cgcattttat tttctttctc tggttctgaa atccatccct
    14941 gtcggtgttg cttatgcagt ctggtcggga ctcggcgtcg tcataattac agccattgcc
    15001 tggttgcttc atgggcaaaa gcttgatgcg tggggctttg taggtatggg gctcataatt
    15061 gctgcctttt tgctcgcccg atccccatcg tggaagtcgc tgcggaggcc gacgccatgg
    15121 tgacggtgtt cggcattctg aatctcaccg aggactcctt cttcgatgag agccggcggc
    15181 tagaccccgc cggcgctgtc accgcggcga tcgaaatgct gcgagtcgga tcagacgtcg
    15241 tggatgtcgg accggccgcc agccatccgg acgcgaggcc tgtatcgccg gccgatgaga
    15301 tcagacgtat tgcgccgctc ttagacgccc tgtccgatca gatgcaccgt gtttcaatcg
    15361 acagcttcca accggaaacc cagcgctatg cgctcaagcg cggcgtgggc tacctgaacg
    15421 atatccaagg atttcctgac cctgcgctct atcccgatat tgctgaggcg gactgcaggc
    15481 tggtggttat gcactcagcg cagcgggatg gcatcgccac ccgcaccggt caccttcgac
    15541 ccgaagacgc gctcgacgag attgtgcggt tcttcgaggc gcgggtttcc gccttgcgac
    15601 ggagcggggt cgctgccgac cggctcatcc tcgatccggg gatgggattt ttcttgagcc
    15661 ccgcaccgga aacatcgctg cacgtgctgt cgaaccttca aaagctgaag tcggcgttgg
    15721 ggcttccgct attggtctcg gtgtcgcgga aatccttctt gggcgccacc gttggccttc
    15781 ctgtaaagga tctgggtcca gcgagccttg cggcggaact tcacgcgatc ggcaatggcg
    15841 ctgactacgt ccgcacccac gcgcctggag atctgcgaag cgcaatcacc ttctcggaaa
    15901 ccctcgcgaa atttcgcagt cgcgacgcca gagaccgagg gttagatcat gcctagcatt
    15961 caccttccgg ccgcccgcta aatatctcct tttgggttgt taataaaaca tccaataagt
    16021 tgactgtgcg tgaaaaagaa agttttgtgt gatggcgttg aagatcgcac cgttaagctc
    16081 ttatgtggga tggtgcagag ctcgacgact accgataaaa cgcaaccgcc gcaaacagac
    16141 aagaaaaagc cccaactgat aacagttggg gcttcagtat tgtgattggt ggagcaatag
    16201 caccctgaac ccaaaacctt ctcgctcaac cggtagtggc tgataacaac tcgtgagggc
    16261 tattgcgggt taagcattta gcgatgtcta gggccagact ggacgtctga acgcaagccg
    16321 ctgatactgt acataaccac agtatcagcg gaggataccc atgtcgctgg caaggaacgc
    16381 cacggcgagt caatcgccca ctcaaacaaa cggttacgaa cgccaccaac ccgaccagac
    16441 gctgctctac cagctggttg agcagcacta cccagccttc aaagcctcac tcgaagccca
    16501 aggtcaacac ctgcctcgct acatccaaca agaattcaac gacctcctcc aatgtggccg
    16561 tctggagtat ggtttcatgc gggttcgctg cgaggattgt catcacgagc gtctggtcgc
    16621 cttcagctgt aaacgacgcg gcttttgccc tagctgcggt gcccgccgga tggccgagag
    16681 tgcggcgctg ctgatagacg aagtcttccc caaggagccc attcgccagt gggtgctcag
    16741 ctttcctttc cagctacgct ttttgctggc tcgccatccc cagctgatgg gccaggtctt
    16801 gagtatcgtc tatcgtacac tctcaactca tctgatcaaa aaagccggtt acaccaaagc
    16861 ctctgcacaa actggctcag tgactcttat ccaacgcttt ggctccgcgc taaatctcaa
    16921 tgtccactac cacatgctgt ttctcgatgg tgtctatgcc gaagatgact atggcaagca
    16981 acgcttccat cgtgtcaagg cacccactta cgatgagctg aatacgctcg ctcacaccct
    17041 cagccatcgc atcgctcgct gcatggaaaa gcgtgggatt ttggagcgtg atgccgagaa
    17101 tacgtggttg acactggaag agggcgaaga cgatacgctg actcaattac atggtgcttc
    17161 ggttacgtat cgcattgccg tcggccccca gcaagggcgc aaagtcttca ccctgcaaac
    17221 cttgccaggg cgtgaggata aagccgactc aagcagtcga gtagccaacc atgctggttt
    17281 ctcgctacac gccggtgtga tggccgaagc gcatcagcgg gataagcttg agcgcttgtg
    17341 tcgctacatt agtcggccag cggtttcaga aaaacgtctg gcattaaccg ccaatgggca
    17401 ggtgcgttac gagctcaaaa ctccgtaccg caatggcacc acccatgtga tcttcgagcc
    17461 gctggacttc atcgccaaac tcgctgcgtt ggtacctaag ccgcgagtca acctcacacg
    17521 cttccacggc gtctttgcac cgaacagcaa acaccgagtt caagtaacac ccgccaagcg
    17581 gggcaagaag cccgacaaat cggaaggtct cgatactaac tggcgtgaca agagtcctgc
    17641 agagcgccac cgcgccatga cctggatgca acgcctcaag cgagtcttca atattgatat
    17701 tgaagtctgc gaacactgcg gcggtcacgt caaagtgatt gccagcatcg aagatccgaa
    17761 ggtcattgag cagattctca agcatctgaa acagaaaaca gccaaggcga atgccgccaa
    17821 gcagcgtgag ctgccaccag aacgagcgcc gccactgact cccagcctgt tcgatccatc
    17881 acagagtcgt ctctttgact gacgacccca aatccaacac tgctcaacac tgccaacttt
    17941 taaacggggc ggtggggcag tttgtatctc tcgagctatc aggctagaga ttttaccgcc
    18001 aaatcgaacc ttattagagc ggtttaggct ggaccggcag ttaaaattgg ggcttgagcg
    18061 gtaaacgagt gagggaattt caggtaagat acttcggatg aggagcaaaa aggtggttta
    18121 tacttcctat acccgttagc accctccctg attaaaggaa gccgtatgga tattattgat
    18181 aaagtttttc agcaagagga tttctcacgc caggatttga gtgacagccg ttttcgccgc
    18241 tgccgctttt atcagtgtga cttcagccac tgtcagctgc aggatgccag tttcgaggat
    18301 tgcagtttca ttgaaagcgg cgccgttgaa gggtgtcact tcagctatgc cgatctgcgc
    18361 gatgccagtt tcaaggcctg ccgtctgtct ttggccaact tcagcggtgc caactgcttt
    18421 ggcatagagt tcagggagtg cgatctcaag ggcgccaact tttcccgggc ccgcttctac
    18481 aatcaagtca gccataagat gtacttctgc tcggcttata tctcaggttg caacctggcc
    18541 tataccaact tgagtggcca atgcctggaa aaatgcgagc tgtttgaaaa caactggagc
    18601 aatgccaatc tcagcggcgc ttccttgatg ggctcagatc tcagccgcgg caccttctcc
    18661 cgcgactgtt ggcaacaggt caatctgcgg ggctgtgacc tgacctttgc cgatctggat
    18721 gggctcgacc ccagacgggt caacctcgaa ggagtcaaga tctgtgcctg gcaacaggag
    18781 caactgctgg aacccttggg agtaatagtg ctgccggatt agctcgaatg caaacacaag
    18841 aggcaaatat cacttgagtt ccgcgctaca acaaggcaga ttctgctata gcagagtatt
    18901 accgccggaa tgccgtttct ctgctgccgc agccgacgtt ataccttccc ttcaaaggag
    18961 gcattatgaa gactcaactg ccctaaagaa aaacttacag gtggattatg gtcagacgtt
    19021 atctccccct taacccgctg cgcgcctttg aggccgccgc ccgtcatctc agttttaccc
    19081 gcgcggcgat tgagctgaat gtcacccatg ccgccgtcag ccagcaggtc agggcgctgg
    19141 aagaacaact cggctgtgtg ctgtttaccc gcgtctcgcg cgggctggtg ctgacccatg
    19201 aaggtgaggg attactgccg gtgctcaatg aggcgtttga ccggattgcg gatactctgg
    19261 agtgtttttc tcacgggcag ttccgtgagc gggtgaaagt cggtgcggtg ggaacatttg
    19321 ccgcaggctg gctgctgccg cgtctggccg gattctatga cagccatccg catattgatc
    19381 tgcatatctc cacccataac aatcatgtgg acccggcggc ggaagggcat gattatacga
    19441 tccgtttcgg taacggcgcg tggcatgagt cagatgcgga actgattttc agtgcaccac
    19501 acgctccgct gtgctcaccg gccattgcag aacagttaca gcagccggat gatgttcacc
    19561 gctttaccct gctgcgctca ttccgccggg atgaatggag ccgctggctg gattgtgcgg
    19621 gcggcacacc gccttccccg tcacagccgg taatggtgtt cgatacctca ctggccatgg
    19681 ccgaggcggc acaactgggt gccggggtag cgatcgcacc ggtatgtatg ttcagccgcc
    19741 tgttacagtc aggcgcactg gtacagccgt ttgccgcaga aatcaccctc ggcggctact
    19801 ggctgacgcg gttacagtcc cgtacggaaa ccccggccat gcagcaattc gcccgctggc
    19861 tgctgaatac ggcggcggcg taaaactcac tcaccttcca ggctttttac ccgcaaatca
    19921 tcaccttcac tgatgcgcag ccgttcactg ccgcagtgcg gacagcatcc ggcgtgctgc
    19981 atgatttcgg cctcacggct gcaatcccag caccatgcct gtgccgggat aacatcaata
    20041 tgcagtgtgc agccctgcgc cacggtatca cggcaggcga tatcaaaaca gaaatgcagt
    20101 gcactctcct caacatccgc cagtgcgccg acttccagcc agacatccgt tacccgcgca
    20161 atgccgtgct gttcagcctg ttcgcggata atgtccgccg caccgagggc tttactaagc
    20221 ttgccccttc cgccgttgtc ataatcggtt atggcatcgc attttatttt ctttctctgg
    20281 ttctgaaatc catccctgtc ggtgttgctt atgcagtctg gtcgggactc ggcgtcgtca
    20341 taattacagc cattgcctgg ttgcttcatg ggcaaaagct tgatgcgtgg ggctttgtag
    20401 gtatggggct cataattgct gcctttttgc tcgcccgatc cccatcgtgg aagtcgctgc
    20461 ggaggccgac gccatggtga cggtgttcgg cattctgaat ctcaccgagg actccttctt
    20521 cgatgagagc cggcggctag accccgccgg cgctgtcacc gcggcgatcg aaatgctgcg
    20581 agtcggatca gacgtcgtgg atgtcggacc ggccgccagc catccggacg cgaggcctgt
    20641 atcgccggcc gatgagatca gacgtattgc gccgctctta gacgccctgt ccgatcagat
    20701 gcaccgtgtt tcaatcgaca gcttccaacc ggaaacccag cgctatgcgc tcaagcgcgg
    20761 cgtgggctac ctgaacgata tccaaggatt tcctgaccct gcgctctatc ccgatattgc
    20821 tgaggcggac tgcaggctgg tggttatgca ctcagcgcag cgggatggca tcgccacccg
    20881 caccggtcac cttcgacccg aagacgcgct cgacgagatt gtgcggttct tcgaggcgcg
    20941 ggtttccgcc ttgcgacgga gcggggtcgc tgccgaccgg ctcatcctcg atccggggat
    21001 gggatttttc ttgagccccg caccggaaac atcgctgcac gtgctgtcga accttcaaaa
    21061 gctgaagtcg gcgttggggc ttccgctatt ggtctcggtg tcgcggaaat ccttcttggg
    21121 cgccaccgtt ggccttcctg taaaggatct gggtccagcg agccttgcgg cggaacttca
    21181 cgcgatcggc aatggcgctg actacgtccg cacccacgcg cctggagatc tgcgaagcgc
    21241 aatcaccttc tcggaaaccc tcgcgaaatt tcgcagtcgc gacgccagag accgagggtt
    21301 agatcatgcc tagcattcac cttccggccg cccgctagcg gaccctggtc aggttccgcg
    21361 aaggtgggcg cagacatgct gggctcgtca ggatcaaact gcactatgag gcggcggttc
    21421 ataccgcgcc aggggagcga atggacagcg aggagcctcc gaacgttcgg gtcgcctgct
    21481 cgggtgatat cgacgaggtt gtgcggctga tgcacgacgc tgcggcgtgg atgtccgcca
    21541 agggaacgcc cgcctgggac gtcgcgcgga tcgaccggac attcgcggag accttcgtcc
    21601 tgagatccga gctcctagtc gcgagttgca gcgacggcat cgtcggctgt tgcaccttgt
    21661 cggccgagga tcccgagttc tggcccgacg ccctcaaggg ggaggccgca tatctgcaca
    21721 agctcgcggt gcgacggaca catgcgggcc ggggtgtcag ctccgcgctg atcgaggctt
    21781 gccgccatgc cgcgcgaacg caggggtgcg ccaagctgcg gctcgactgc cacccgaacc
    21841 tgcgtggcct atacgagcgg ctcggattca cccacgtcga cactttcaat cccggctggg
    21901 atccaacctt catcgcagaa cgcctagaac tcgaaatcta acgtccgttc gggcatcgag
    21961 gtccatgtcg gggtgggacg ggcccgtggc ttcaagatca cttgcagtcc gaccgcgatg
    22021 tcttggttgc gcgagaggtt gtcgatatcc tccacttcca tcatcaaccc tggataatgc
    22081 cgccgccgtc atcgccgccg acgcccgtgc cgggcttttc gggcctgtca ggcttgctcg
    22141 gccttcagcc tgcctgggcg agatctccgg cggacggatt aacggcggag cttcgccgcc
    22201 tttcgtgcgt gtgaaggccg aagatagttc tctcaaaaac atccgtttat gagagatacc
    22261 aaatgtcatt ttcagaagac gactgcacca gttgattggg cgtaatggct gttgtgcagc
    22321 cagctcctga cagttcaata tcagaagtga tctgcaccaa tctcgactat gctcaatact
    22381 cgtgtgggct ctgttgcaaa aatcgtgaag cttgagcatg cttggcggag attggacgga
    22441 cggaacgatg acggatttca agtggcgcca tttccagggt gatgtgatcc tgtgggcggt
    22501 gcgctggtat tgtcgctatc cgatcagcta tcgcgacctt gaggaaatgc tggcggaacg
    22561 cggcatttcg gtcgaccata cgacgatcta tcgctgggtc cagtgctacg ccccggagat
    22621 ggagaagcgg ctgcgctggt tctggcggcg tggctttgat ccgagctggc gcctggatga
    22681 aacctacgtc aaggtgcggg gcaagtggac ctacctgtac cgggcagtcg acaagcgggg
    22741 cgacacgatc gatttctacc tgtcgccgac ccgcagcgcc aaggcagcga agcggttcct
    22801 gggcaaggcc ctgcgaggcc tgaagcactg ggaaaagcct gccacgctca ataccgacaa
    22861 agcgccgagc tatggtgcag cgatcaccga attgaagcgc gaaggaaagc tggaccggga
    22921 gacggcccac cggcaggtga agtatctcaa taacgtgatc gaggccgatc acggaaagct
    22981 caagatactg atcaagccgg tgcgcggttt caaatcgatc cccacggcct atgccacgat
    23041 caagggattc gaagtcatgc gagccctgcg caaaggacag gctcgcccct ggtgcctgca
    23101 gcccggcatc aggggcgagg tgcgccttgt ggagagagct tttggcattg ggccctcggc
    23161 gctgacggag gccatgggca tgctcaacca ccatttcgca gcagccgcct gatcggcgca
    23221 gagcgacagc ctacctctga ctgccgccaa tctttgcaac agagccctca ataacgtgat
    23281 cgaggccgat cacggaaagc tcaagatact gatcaagccg gtgcgcggtt tcaaatcgat
    23341 ccccacggcc tatgccacga tcaagggatt cgaagtcatg cgagccctgc gcaaaggaca
    23401 ggctcgcccc tggtgcctgc agcccggcat caggggcgag gtgcgccttg tggagagagc
    23461 ttttggcatt gggccctcgg cgctgacgga ggccatgggc atgctcaacc accatttcgc
    23521 agcagccgcc tgatcggcgc agagcgacag cctacctctg actgccgcca atctttgcaa
    23581 cagagcctcc gtcgccatgc tcacctcgct ttggtgcaca cgagtattga gcatagtcga
    23641 gattggtgca gatcacttct gatattgaac tgtcaggagc tggctgcaca acagccatta
    23701 cgcccaatca actggtgcag tcgtcttctg aaaatgacac atggcatctg acatcaagtt
    23761 agggtatgcc tcaatctgac ggctgcgaac cgccagggac aggcgcaatg tcagattctg
    23821 tcgcggcctt ggcgcgtgcc tggaagcgtt catagcaatc cagcccgcag aaatgttcga
    23881 cgtattccgc gccttccggg gtgaaggcgg catcgagcgg aatttctttg cagcatacgc
    23941 agcaggtggt gcaactggca gtgttcgggg cgtttgcgtt catggtggta ctcctccaga
    24001 ttggtagcga agctcaaagc tgcccactct cggctggctg ggaagcggtc atgatcttcc
    24061 cttgaaggcc cgcagcagcc gcgtcacaga caggacaaac aagccggtca gcgtgagggc
    24121 tgcaataccc cagtgctccc cgatgaacgc gccggccgtc gtgccggcta gcacaatggc
    24181 gagaatcggc aaatggcagg gacaggtgag cacggccagc gcgccccaca agtagccggt
    24241 gatcggtttg tgcgtctcag acggcaagtg ctctgggctg ttcatggcag actctccgcg
    24301 tgctgtgccg gtttcggttg gcatggcggc cagttgcatt tcgaggctgg ccagggcctc
    24361 gcgccgacgc tcgacgagtt gccgcaacac ggcaagctgc gcagacgcac cgtcaccgtc
    24421 cgcagcatcc agcgcccggc acagccgcgc cagtgcgtcc aggccgatac ccgcttcgaa
    24481 ggcagcccgt acaaagcgca gccgttgcaa cgcggtgtca tcgaacaagc cgtagccgcc
    24541 cgtggtgtac gcgaccggcc gtagcaatcc gcgcagcagg tagtcgcgca cgatatgcac
    24601 gctcaccccg gcatcaaggg ccagccggga cactgtgtag gcgctcattg aacacctcct
    24661 tttcctcatc cggcgcgcag cacgaaagct gcttcacgtc cttgctgaag gtctgcgccg
    24721 cgagcttcag cccttcgacc atggtcaggt aggggaacaa ttggtcgggc cagttcctgc
    24781 acggtcatac ggttgcgaat ggcgagcacc gccgtctgga tcagttcacc cgcttccggg
    24841 gccaccgctt gcacgccgat gagccgtccg ctaccttcct cgatgaccag cttgatgaag
    24901 ccgcgtgtgt cgaagttggc aagcgcacgc ggcacgttat ccagtgttag caggcgactg
    24961 tcggtctcga tcccgtcgtg atgtgcttcc gcctcgctgt agcccacggt ggcgacctgc
    25021 gggtcggtga acaccacggc cggcattgcg gtcaggtcca gggccgcatc gccgccagtc
    25081 atgttgatcg ccgcacgagt gccggccgct gccgccacat agacgaactg cggctggtcg
    25141 gtgcagtcgc cggccgcgta gatgttcggg ctactggtgc gcatgccctt gtcgatgacg
    25201 atggccccct gcgcattgac gctacccccg ccgcttccaa tgccaggctg cgcgtgttcg
    25261 gtgtccggcc ggtggcgacc agcagcttgt cggcgcgcaa ttcaccgtgc gtggtggtca
    25321 gcacgaattc accgtccata tgggcgacct ggctggcttg cgtgtgctcc agcacctcga
    25381 tgccctcggc acggaaagcg gctgtcaccg cctcgccgat ggccgggtct tcacggaaga
//
