LOCUS       NZ_CP066917            10060 bp    DNA     circular CON 30-JUL-2023
DEFINITION  Klebsiella pneumoniae strain XHKPN391 plasmid pXHKPN391-2, complete
            sequence.
ACCESSION   NZ_CP066917
VERSION     NZ_CP066917.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN17174001
            Assembly: GCF_024346895.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 10060)
  AUTHORS   Zhu,W.
  TITLE     Genome sequence of XHKPN391 which was isolated at July 26, 2018
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10060)
  AUTHORS   Zhu,W.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-DEC-2020) Clinical Laboratory, Xinhua Hospital
            Affiliated to Shanghai Jiaotong University School of Medicine, 1665
            Kongjiang Road, Shanghai 200092, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 6
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 447.0x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 07/30/2023 03:55:57
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.5
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,743
            CDSs (total)                      :: 5,620
            Genes (coding)                    :: 5,472
            CDSs (with protein)               :: 5,472
            Genes (RNA)                       :: 123
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 86
            ncRNAs                            :: 12
            Pseudo Genes (total)              :: 148
            CDSs (without protein)            :: 148
            Pseudo Genes (ambiguous residues) :: 0 of 148
            Pseudo Genes (frameshifted)       :: 56 of 148
            Pseudo Genes (incomplete)         :: 100 of 148
            Pseudo Genes (internal stop)      :: 14 of 148
            Pseudo Genes (multiple problems)  :: 22 of 148
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP066917.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..10060
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="XHKPN391"
                     /isolation_source="sputum"
                     /host="Homo sapiens"
                     /db_xref="taxon:573"
                     /plasmid="pXHKPN391-2"
                     /geo_loc_name="China: Shanghai"
                     /lat_lon="31.21 N 121.45 E"
                     /collection_date="2018-07-26"
                     /collected_by="Xinhua Hospital"
     gene            join(8097..10060,1)
                     /locus_tag="JG797_RS28590"
     CDS             join(8097..10060,1)
                     /locus_tag="JG797_RS28590"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004178196.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TraM recognition domain-containing protein"
                     /protein_id="WP_071177727.1"
                     /translation="MFNTDSLAWQWHIPELARQIYPWVSWLYREYYSLAGFFLVIGLFF
                     GLAELWAGRMRFVGLSHKARREYADRYKRDNNRTVPFSVLASLDSPGRMVRARRHVWNY
                     AYWLTGAAGLALLGGLVVAVFIESWGETVLRPDLYANADYYLLQPANLFGIAWCAGGLV
                     AGVLLARLLAFLLLDGHFAAADEAVNAKLNQESRRSSQRTGEMTDVRHLHFGEPVPVNA
                     LADFSTEQARKQQAVFLGKDEQGQPVLVPRDTWRKTNIQILGLPGSGKSAMATNALIRC
                     VRDFGDAVVYFDPKGDAWAPHVFRAHCPDFTLLDLRPGKPAQLNLFRDLDQYALKNLLV
                     AGFNLSETGDVADHYRISEQKAAKLIAEQFPQGANIQQVLAAAYALPEALKKDVKGLIT
                     KLENVADLSVLQTDSGIDVAGIINGGGCLYVIGSMDDEAVIRVQKMLFARCAQIIIARD
                     EFRRWPHASIMLDEIKYLLSKYVLNALGTLRSRDCNLLLAHQSLGDFGQCGQDLPADFV
                     KTTVLDNTPIRWFYRAASQESAQWAAGQTGEIRVDVERRRASREAGNVEHISGDSFIQK
                     EARPLFDVNTLQHLPDGFAVMTGLGVARLAFSSPLRVERREISLKTFPVLAKTDPLAEY
                     LPPADGGGPKADDDFAGLY"
                     /name="TraM recognition domain-containing protein"
     gene            1..732
                     /gene="mobC"
                     /locus_tag="JG797_RS28595"
     CDS             1..732
                     /gene="mobC"
                     /locus_tag="JG797_RS28595"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobC family replication-relaxation protein"
                     /protein_id="WP_071177728.1"
                     /translation="MTLEQYNVSHAKRQARNAEKTRLTLRWLREELCSTAELVARRLGI
                     AAVQPVYRFLDSLVAKGLLVRAKYPVDGRQVSVWGLTPHGVAFSFDEDEPLTDVIPFQP
                     SRVSAAQLPHRLAVQSLRLSMEGRGATGWRYLHRMALKGMKVPDALAELDGRTVAFEVE
                     RTVKSRRRYQEVVSGYLFNRRANGIDEIWYICPDRPTLVRVQRAILAVDEIVNPQTGEA
                     RKTVELDRERLFACFKFMTTE"
                     /name="mobC"
     gene            739..1269
                     /locus_tag="JG797_RS28600"
     CDS             739..1269
                     /locus_tag="JG797_RS28600"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_071177729.1"
                     /translation="MALYMVFIEDVEDKDGERCIMPTSEHLEDMVVLAWQTGAYVFCFV
                     DRAQHLAMMKSIGMYDERLNSDEKATYFFTGENPQWERDKPTGMKLCDYLYRKVERFAI
                     ENGVQVVDAGKCSPEQINAMIEVVSERHGESAVNEKLKAELMREYNSRYFNVPVPELPE
                     DKPARRWWPFGKK"
                     /name="hypothetical protein"
     gene            complement(1296..1475)
                     /locus_tag="JG797_RS28605"
     CDS             complement(1296..1475)
                     /locus_tag="JG797_RS28605"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rop family plasmid primer RNA-binding protein"
                     /protein_id="WP_000165970.1"
                     /translation="MTKQEKTALNMAKFIKDQSLLLLEKLNELDMDTPADMCERLHEDA
                     ETLWQVMRDKLGEE"
                     /name="Rop family plasmid primer RNA-binding protein"
     gene            complement(1501..1929)
                     /locus_tag="JG797_RS28610"
     CDS             complement(1501..1929)
                     /locus_tag="JG797_RS28610"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001140599.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001140599.1"
                     /translation="MAKTLLNLSQAAQAAGITRRTLYNHVKQGKVTVSRDGKNNPVVDV
                     SELIRVYGNVNIPEKQIPGISHRENTQKNFPQEQLLAMQKELADLRQAVTLMLEDKTSR
                     EEERRQHDDERRKLQAEVDRLTTELTQKKKRFWSGWFS"
                     /name="hypothetical protein"
     gene            complement(2093..2407)
                     /locus_tag="JG797_RS28615"
     CDS             complement(2093..2407)
                     /locus_tag="JG797_RS28615"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001136729.1"
                     /GO_function="GO:0008657 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) inhibitor activity
                     [Evidence IEA]; GO:0042803 - protein homodimerization
                     activity [Evidence IEA]"
                     /GO_process="GO:0030541 - plasmid partitioning [Evidence
                     IEA]; GO:0051290 - protein heterotetramerization [Evidence
                     IEA]; GO:0009432 - SOS response [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_071177730.1"
                     /translation="MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKT
                     LPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDREMDQIVIVTVRHQKESGYPGADSL
                     "
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            complement(2395..2673)
                     /locus_tag="JG797_RS28620"
     CDS             complement(2395..2673)
                     /locus_tag="JG797_RS28620"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014542884.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CopG family ribbon-helix-helix protein"
                     /protein_id="WP_000093040.1"
                     /translation="MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEK
                     RSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWGTENEQDAPPCHR"
                     /name="CopG family ribbon-helix-helix protein"
     gene            complement(2848..3213)
                     /locus_tag="JG797_RS28625"
     CDS             complement(2848..3213)
                     /locus_tag="JG797_RS28625"
                     /inference="COORDINATES: protein motif:HMM:TIGR01352.1"
                     /GO_function="GO:0015291 - secondary active transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TonB family protein"
                     /protein_id="WP_072354022.1"
                     /translation="MKAFTLTVLAAMFLTPVHAIPLKPVTTLQPTYPVQAAAKRIEGQV
                     TATFDILDDGRVDNVSLTGCHLFFRETLTAMRHWLYPAGHPAMRQVINFEFSLKNDGLQ
                     DPRPVTTQKLNDDGCRQ"
                     /name="TonB family protein"
     gene            complement(3210..3581)
                     /gene="tolA"
                     /locus_tag="JG797_RS28630"
     CDS             complement(3210..3581)
                     /gene="tolA"
                     /locus_tag="JG797_RS28630"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001237044.1"
                     /GO_component="GO:0098567 - periplasmic side of plasma
                     membrane [Evidence IEA]"
                     /GO_function="GO:0005215 - transporter activity [Evidence
                     IEA]"
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell envelope integrity protein TolA"
                     /protein_id="WP_001237044.1"
                     /translation="MRLIPFILLALCSPLLLTACKHSTTQPPKIYTLDKSSKISSYAAA
                     IKTAVEMQMFEPEAYAGKMCTVRISIQRDGTLNSAIAEGGDPKLCKAAISAVTHAKIPP
                     APDENTWQIFKNAPLDFRP"
                     /name="tolA"
     gene            complement(3855..4100)
                     /locus_tag="JG797_RS28635"
     CDS             complement(3855..4100)
                     /locus_tag="JG797_RS28635"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146442.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_032440458.1"
                     /translation="MTHLKLTPAEEKRLADAFVAQALAMGLKGNKTLPKAVKQQVRERV
                     LRAIQDEREARRAQEMRREKYEATETTFTWQPQRRR"
                     /name="hypothetical protein"
     gene            4427..6112
                     /locus_tag="JG797_RS28640"
     CDS             4427..6112
                     /locus_tag="JG797_RS28640"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin-like bacteriocin tRNase domain-containing
                     protein"
                     /protein_id="WP_032440457.1"
                     /translation="MSGGDGRGPGNSGLGHNGGQASGNVNGTSGKGGPSSGGGTDPNSG
                     PGWGTTHTPNGDIHNYNPGEFGNGGSKPGGNGGNSGNHSGSSGGGQSSATAMAFGLPAL
                     ATPGAEGLALSVSGDALSAAVADVLAALKGPFKFGLWGIAIYGVLPSEIAKDDPKMMSK
                     IMTSLPADAVTETPASTLPLDQATVRVRQRVVDVVKDERQHIAVVAGRPMSVPVVDAKP
                     TKRPGVFSVSIPGLPSLQVSVPKGVPTAKAPPKGIVAEKGDSRPAGFTAGGNSREAVIR
                     FPKETGQKPVYVSVTDVLTPAQVKQRQEEEKRRQQAWDAAHPEEGLKRDYDKAKAELDA
                     EDKNIATLNSRIASTEKALPGARAAVQEADKKVKEAEANKDDFVTYNPPHEYGSGWQDQ
                     VRYLDKDIQNQNEKLKAAQASLNAMNESLSRDKAALTGAMESRKQKEKKAKDAENKLNE
                     EKNKPRKGTKDYGHDYHPVPKTEDIKGLGELKRGDPKTPKQGGGGKRARWYGDKKRKIY
                     EWDSQHGELEGYRASDGEHLGAFDPKTGKQVKGPDPKRNIKKYL"
                     /name="colicin-like bacteriocin tRNase domain-containing
                     protein"
     gene            6122..6379
                     /locus_tag="JG797_RS28645"
     CDS             6122..6379
                     /locus_tag="JG797_RS28645"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891189.1"
                     /GO_function="GO:0015643 - toxic substance binding
                     [Evidence IEA]"
                     /GO_process="GO:0030153 - bacteriocin immunity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin E3-like toxin immunity protein"
                     /protein_id="WP_032440455.1"
                     /translation="MGLKLRLTWFDKKTEEFKGEEYSKDFGDDGSVIESLGMPLKDNIN
                     NGEFDLKKEWVPLLQPFFKNQIKPDVDNCYIAFDYRDGNW"
                     /name="colicin E3-like toxin immunity protein"
     gene            6464..6613
                     /locus_tag="JG797_RS28650"
     CDS             6464..6613
                     /locus_tag="JG797_RS28650"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891188.1"
                     /GO_component="GO:0019867 - outer membrane [Evidence IEA]"
                     /GO_process="GO:0019835 - cytolysis [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin release lysis protein"
                     /protein_id="WP_032440454.1"
                     /translation="MKKVKTIFLFILIVAGFLLAACQANYIRDVQGGTVAPSSSSELTG
                     IAVQ"
                     /name="colicin release lysis protein"
     BGC             1..10060
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          complement(6717..7295)
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="98.282"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          2..729
                     /name="MOBC"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="93.416"
                     /coverage="100.0"
                     /evalue="1.34e-140"
ORIGIN
        1 atgacactgg agcagtacaa cgtcagccac gcgaagcggc aggcgcggaa cgcggagaaa
       61 acacggctga ccctgcgctg gctgcgggaa gagctgtgtt ccacggcgga gctggttgcg
      121 cgacggctgg ggattgcggc ggtacagccg gtttaccgct tcctggacag tctggtggcg
      181 aaagggctgc tggtccgggc gaaatacccg gttgacggcc gtcaggtcag cgtgtggggg
      241 ctgacgccgc acggggtggc gttctcgttc gacgaggacg agccgctgac ggacgttatt
      301 ccgtttcagc cgtcaagggt gtcggcggcg cagctgccgc accggctggc cgtgcagtcc
      361 ctgcgcctct ccatggaggg ccggggggcc accggctggc ggtacctgca ccgtatggcc
      421 ctgaaaggga tgaaagtgcc ggacgcgctg gcggagctgg acggcagaac ggtggcattt
      481 gaggtagagc gcaccgtcaa gagccgcagg cggtatcagg aagtggtgtc cgggtatctg
      541 ttcaaccgcc gggcgaacgg catcgatgaa atctggtaca tctgccctga ccggccgacg
      601 cttgtccggg tacagcgggc gattctggcg gtggatgaaa tcgtgaatcc acagaccggc
      661 gaggcccgca aaacggtgga gctggaccgg gagaggctgt tcgcgtgctt taaatttatg
      721 acaacggagt gagggattat ggcgctgtac atggtattta ttgaggacgt ggaagacaaa
      781 gacggcgagc gctgcattat gccaaccagc gagcatctgg aagacatggt ggtgctcgcc
      841 tggcagaccg gggcgtatgt tttctgtttt gtcgaccggg cccagcatct ggcgatgatg
      901 aaatccatcg ggatgtatga cgagcggctc aacagcgacg aaaaagccac gtactttttc
      961 accggtgaaa atccgcaatg ggaacgggac aaacccacag gaatgaagct gtgtgattac
     1021 ctctatcgaa aggtggagcg gttcgccatc gagaacggtg tgcaggtggt tgatgccggg
     1081 aagtgctcac cggagcagat taacgcgatg attgaggtgg tcagcgagcg gcacggggaa
     1141 agcgcggtga acgagaagct gaaagcggag ctgatgcggg aatataacag ccgctatttt
     1201 aacgtgccgg tgcctgaact gccggaggac aaacccgccc gccggtggtg gccgttcggc
     1261 aaaaaataac gccagcaccg gcatggccgg tgctgttatt cttccccgag cttatcccgc
     1321 atcacctgcc agagtgtttc cgcatcctcg tgaagccgtt cgcacatgtc ggccggggta
     1381 tccatgtcca gctcgttcag cttttccagc aacagcagcg actgatcctt aatgaattta
     1441 gccatattga gggcagtttt ttcctgcttc gtcatgttct ccattccctt cggtaagttc
     1501 tcagctaaac cagccggacc agaagcgttt tttcttctgt gtcagttctg ttgtcaatct
     1561 gtccacttcg gcctggagtt tccggcgctc atcatcgtgc tggcggcgtt cttcttcccg
     1621 ggatgtttta tcttccagca tcagggtgac agcctgccgg agatcggcca gttccttttg
     1681 cattgccaga agctgttcct gtgggaaatt tttttgtgta ttttcacggt gtgaaatgcc
     1741 gggaatttgt ttctcaggga tattcacatt tccgtataca cggatcagtt ctgacacatc
     1801 cacgacaggg ttgtttttcc cgtcacgtga cacggtaacc tttccctgtt ttacatgatt
     1861 gtatagcgtt cttctggtaa tgcccgcggc ttgtgctgcc tgtgaaaggt tgagcaatgt
     1921 tttcgccact gtatacccct gattttatcg ggtgtgaaag gtgtgtaatt tctcacggta
     1981 aatgtatcgc tgaattttac ccgtttttcc gttcaggatg tggttttctg acgcgctgcg
     2041 cttgtcaaac cggcgacggc cacgcaatga attgcgcccc cgtcatcggt tattagaggc
     2101 tgtctgcccc cggatacccg gattctttct gatgcctgac ggtgacgatc acaatctggt
     2161 ccatttcccg gtcgtggcgg tagagcatca catagccact gtcgccaaac ccgatcacca
     2221 gttccttata ttccagcggc agaaacggca ccgggcggcc aatgtctggc aatgttttca
     2281 gttgctggat agcccggacg atcacctcac ctccttttct ggctgccagc cgatttttgg
     2341 ttttgagaaa gtcctgaagg cgttgtaaat cgcgctgtgc cagcgcggaa atcgttacct
     2401 gtggcatggc ggagcatcct gctcgttctc agttccccag gtacttatcc aggcttccgc
     2461 ttcttccgca gtaaggtgca gacccgtttc ctgatagtgc tgccatgcgg cctgtccgtc
     2521 ccgcaggtac tggctgcgct tctcttcccg gtcgatgtat tcggtgattg cctccagcat
     2581 tagcgcgtgc gctgagcggt gccggtcatc ggccagcgtt ttcagccggt ccttaagttc
     2641 ttcatcgagc ctgatggatg ttgctgatga cataaaagcc cctttgtagt catatgtatt
     2701 acacatgact actttaatcc gtggcggcgc tatttgccag aaatacggct tttgctgccc
     2761 atttttcagc ttcgcttcca ctaatcaggg ctgctacagg ctcactcatc atccaggact
     2821 attgcagcct gcgggttaaa ggacctgtta ctggcggcaa ccatcatcat tgagcttttg
     2881 ggtggtgact ggtcgcggat cctgtaagcc gtcatttttc agactgaatt caaaatttat
     2941 aacctgtcgc attgccgggt gccctgcggg atatagccag tgcctcattg ccgtcagcgt
     3001 ttcccgaaaa aaaaggtgac agccggtaag cgacacgttg tccactcgtc catcgtccag
     3061 aatatcaaac gtggcggtca cctgaccttc gatgcgtttt gctgcggcct gtaccgggta
     3121 ggttggctgc agtgtggtta cgggttttag tggtatcgca tgtaccggag tgaggaacat
     3181 ggccgccagc actgtcagag taaaagcttt catggtctga aatccagagg ggcgtttttg
     3241 aatatttgcc aggtattttc atccggtgcc ggcggaattt tggcgtgggt aacggctgat
     3301 attgctgctt tacagagttt cggatctcct ccttcagcaa tggcgctgtt cagagtgcca
     3361 tcacgttgta tggatatccg cacggtgcac atttttcccg cataggcctc tggttcaaac
     3421 atctgcattt caacagcggt cttgatggcc gcagcgtagc tactgatttt agatgactta
     3481 tccagagtat aaattttcgg cggctgggtg gtggaatgct tacaggccgt caggagtaag
     3541 gggctgcaca atgccagcag gataaagggt attaaacgca tcgggttgat gacctgtcag
     3601 taaaaaatgt tacatgtata tttgtcactc tttacggcca cgttcattta cataaacacg
     3661 gcttatcgta tcgtttttac accaaacggc ccgccatgca gttgcgtgca taggcatgca
     3721 gcgggttaca atttaccggg cgcgtttccg gcggttttcc gggtggtttg ttgcctgttt
     3781 tatcccgtag ccgccggaaa cgccctcaga ccgtctgagc ggtgcgggca atgcgacgtt
     3841 atggtaaata ccccttaccg gcggcgctgt ggctgccagg tgaaggtggt ttccgtagcc
     3901 tcgtatttct cccgacgcat ttcctgcgcc cgcctggctt cacgttcgtc ctgaatggca
     3961 cgaagcaccc tttcccgcac ctgttgtttt accgcctttg gcagcgtttt gttccctttc
     4021 aggcccatgg ccagtgcctg agcgacaaag gcgtccgcca ggcgcttttc ttcagcggga
     4081 gtcagtttca ggtgcgtcat agtggcctcc gggcgtctca ggtttcccga acagtttaac
     4141 cgcaggtcct ctcctcatgc cagttagctt tcagatgtgt ctataccatc tgaaatgtaa
     4201 gtgtgatgaa tgtcttaaat aataaaattt gttgccatga gaaattttcg ggaaaagacg
     4261 cgatctgctt acaggtggct ccgggcgctt ttttgtgcct gaagatgaga actaatctca
     4321 tatattgaca cctgaaaacg ggaggagtaa ggtaataatt atactgtgta tatgtacagt
     4381 atgttggctt taatttattg ttttaaatgt caaagaggaa aacggtatga gtggtggaga
     4441 cggtcgaggt ccgggtaatt caggtctggg acataatggt ggtcaggcca gtgggaatgt
     4501 gaacggtacg tctggtaaag gtggcccttc atcaggtggt ggtacggatc caaacagcgg
     4561 gccgggctgg ggtacgacgc atacgccgaa tggagatatt cataactata atccggggga
     4621 gtttggtaac ggcgggagta aacccggtgg taatggtggt aacagcggca atcatagcgg
     4681 tagctctggt ggcggacagt cttcggccac tgcgatggcc ttcggtctgc ctgccctggc
     4741 tactccgggg gctgaaggac tggctttatc agtttccggc gatgcgttgt cggccgccgt
     4801 tgctgatgtg ctggctgccc tgaaggggcc gtttaagttt ggtctgtggg ggattgcgat
     4861 ctacggtgtg ctgccttctg agattgcaaa agatgatccg aaaatgatgt caaaaattat
     4921 gacgtcatta ccggccgatg cggtgacgga gactccggca agtactttac cactggacca
     4981 ggcgacggtt cgtgtcagac aacgggttgt ggatgtggtg aaggatgagc ggcagcatat
     5041 tgcggttgtc gcaggtcggc caatgagtgt ccctgtggtg gatgcgaaac cgacaaaacg
     5101 tccgggggta ttcagtgtgt cgattccggg tctcccgtct ctgcaggtga gcgtaccgaa
     5161 aggtgttccg acagcgaaag ccccgccaaa aggcattgtt gctgaaaaag gtgattcacg
     5221 tccggctggt tttacagccg gtggtaactc ccgtgaggcc gttattcgtt tcccgaaaga
     5281 gaccggacag aagccggttt atgtgtcggt gacagatgtt cttaccccgg cacaggtaaa
     5341 acagcgtcag gaggaagaaa agcgtcgcca gcaggcatgg gacgccgctc atccggaaga
     5401 ggggctgaaa agagactatg ataaagcgaa agctgagctg gatgccgaag ataaaaatat
     5461 tgcgacctta aacagccgca ttgcatcgac agagaaggcg ctccccggtg caagggctgc
     5521 tgttcaggaa gccgataaaa aggtaaaaga ggcagaggca aataaagatg attttgtgac
     5581 ttataacccg cctcatgaat atggctccgg gtggcaggat caggttcgct atcttgataa
     5641 ggatattcag aatcagaatg agaaattaaa agcggctcag gcatctttaa acgcaatgaa
     5701 tgaatcctta tccagagata aggctgcact taccggggcg atggagagcc ggaaacaaaa
     5761 ggagaaaaaa gcgaaggatg cagaaaataa gttaaatgag gaaaagaaca agcctcgcaa
     5821 ggggactaaa gactacggcc atgattatca tccagtacct aaaacagaag acataaaggg
     5881 acttggagag ttaaagcgag gtgatcctaa aacacctaaa caaggtggtg gtggtaagcg
     5941 ggcccgatgg tatggcgata aaaaacgtaa aatttatgaa tgggattccc agcacggtga
     6001 gcttgaaggg tatcgtgcca gtgatggcga acacctaggc gcatttgatc ccaaaacggg
     6061 taagcaggtt aaagggccag atccaaaacg gaacattaaa aaatatcttt gagaggtaaa
     6121 tatggggctt aaattacgtt tgacatggtt tgataagaaa actgaagagt ttaaagggga
     6181 agagtattct aaagactttg gtgacgatgg ttctgtcatt gaaagcttgg gaatgccttt
     6241 aaaggataat attaataatg gtgagtttga tttgaagaaa gaatgggttc ctttactaca
     6301 gccatttttt aaaaatcaaa taaaacctga tgtggataat tgttatatag cttttgatta
     6361 tcgggacggt aactggtaac aaaaaattat caaggatgat ttgaaatact gacttccggt
     6421 gttcagggat gaatgccgga gtctttaaat acagggaaag tatatgaaaa aggtaaagac
     6481 tatttttctt tttatattga ttgttgctgg ctttcttctg gccgcatgtc aggcaaatta
     6541 tatccgggat gttcagggcg gaacggtggc accatcgtcc tcctctgaac tgacggggat
     6601 cgcggttcag tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc
     6661 ttttgccctg taaacgaaaa aaccacctgg ggaggtggtt tgatcgaagg ttaagtcagt
     6721 tggggaactg cttaaccgtg gtaactggct ttcgcagagc acagcaacca aatctgtcct
     6781 tccagtgtag ccggactttg gcgcacactt caagagcaac cgcgtgttta gctaaacaaa
     6841 tcctctgcga actcccagtt accaatggct gctgccagtg gcgttttgcg tgctttcccg
     6901 ggttggactc aagtgaacag ttaccggata aggcgcagca gtcgggctga acggggagtt
     6961 cttgcttaca gcccagcttg gagcgaacga cctacaccga gccgagatac cagtgtgtga
     7021 gctatgagaa agcgccacac ttcccgcaag ggagaacggc ggacaggtat ccggtaaacg
     7081 gcagggtcgg aacaggagag cgcaagaggg agcgacctac cggaaacggt ggggatcttt
     7141 aagtcctgtc gggtttcgcc cgtactgtca gattcatggt tgagcctcac ggctcccaca
     7201 gatgcaccga aaaagcgtct gtttatgtga actctggcag gagggcggag cctatggaaa
     7261 aacgccaccg gcgcggccct gccgttttgc ctcacatgtt agtcccctgc ttatccacgg
     7321 aatctgtggg taactttgta tgtgtccgca gcgcccgccg cagtctcacg cccggagcgt
     7381 agcgaccgag tgagcgagga ggcgcaattt ccccggcacc tgcaagacgg tcaccggacg
     7441 cgctgatgtg ggatattgtc ccctgattaa gtctttctat tccctgacga tcaattatca
     7501 ggataggtga accatgtcgg tttttcgctg aacattttac gttaacctat ctctgttgct
     7561 tttttctcct tgcggagaaa tgcaagtcat ccccgctggg gcgtggctga cttcagggga
     7621 aaagaccttg cttacgctgg ctggacgcca ccgacgcacg gtcttttccc ctctttctgg
     7681 ctctgtccgg ctggacgccg gccacgccag aaattcaccc ggcccccgtc aggctcacgc
     7741 ctgaccaccc acaaaaatcc acggtgctgg acgcacctga cgaagcagca aagctgctcc
     7801 tgattttgcg ggtggtcagc cgctcgctat ggcgaactct gacgggggcc ggaacaccgg
     7861 aaaagaccgc actggggtgc cgccttttcc tctcacacgc tggggcgtgc tcgttgttcc
     7921 tccggggctg cgccttttcc gcatggggcg gaaagaggct ggcctccgcg gtgaaagctg
     7981 aacgcaatca ccacggacgt gaccgccgcc gccatgcctt ggggcatgtc cgcggcttgt
     8041 gcagcggggg ctgcgcatca cgccggtaaa cccgtcgtct gaaggagaga gattgcatgt
     8101 ttaatacgga ttcgcttgcc tggcagtggc atatcccgga gctggcccgg cagatttacc
     8161 cgtgggtcag ctggctgtac cgggagtatt acagtctggc cggttttttt ctggttatcg
     8221 gcctgttttt cggtctggct gaactctggg ccggccgaat gcgttttgtg gggctgagcc
     8281 ataaggcgcg gcgggagtat gccgatcgct ataagcgcga taataaccgg actgtgccat
     8341 tttcggtgct ggcctcgctg gattcacccg ggcggatggt cagggcacgg cgacatgtct
     8401 ggaactacgc gtactggctg accggcgctg ccggtctggc ccttctgggg gggctggttg
     8461 tcgccgtgtt tatcgagagc tggggagaaa ccgtcctgcg cccggacctc tatgcgaacg
     8521 cagattatta cctgctgcag ccggctaacc tgttcgggat agcctggtgt gccggagggc
     8581 ttgtcgccgg cgtccttctg gcgcggctgc tggcgttcct gctgcttgat ggtcattttg
     8641 cggccgctga cgaggcggtg aacgcgaaac tgaatcagga gagccggcgc agcagccagc
     8701 ggaccggaga aatgacagac gtccgccacc tgcatttcgg ggagccggta ccggttaacg
     8761 cgctggccga tttttccacg gagcaggccc ggaaacagca ggcggtgttt ctgggtaagg
     8821 atgagcaggg ccagccggtg ctggtccctc gtgatacctg gcgcaagacc aatattcaga
     8881 tcctcggcct gcccgggagc ggcaagagcg cgatggccac caacgcgctc attcgctgcg
     8941 tacgcgattt cggggacgct gtggtgtact tcgaccccaa aggggacgcg tgggcgccgc
     9001 acgtcttccg ggcgcactgc ccggacttca ccctgctgga tctgcggccg gggaaaccgg
     9061 cgcagctgaa tctgttccgc gatctcgacc agtacgccct gaagaatctg ctggttgccg
     9121 ggtttaacct gagtgagacc ggcgacgtgg cggaccacta ccgcatcagc gagcagaaag
     9181 cggcgaagct gattgcggag cagttcccgc agggggcaaa cattcagcag gtgctggcgg
     9241 cggcgtacgc gttgccggag gccctgaaaa aggacgtgaa ggggctgatc accaagctgg
     9301 agaacgtggc cgacctgagc gtcctgcaga cggacagcgg tatcgatgtg gcggggataa
     9361 tcaacggcgg cggctgcctg tacgtcatcg gctcgatgga cgatgaggcg gtgatccggg
     9421 tgcagaagat gctgtttgcc cgctgcgcgc aaatcatcat tgcgcgggat gagttccgga
     9481 ggtggccgca cgcgagcatc atgctcgatg agattaaata tctgctgtcg aagtacgtgc
     9541 tgaacgcgct ggggacgctg cgcagccggg actgcaacct gctgctcgcg caccagtcgc
     9601 tgggcgactt cggtcagtgc gggcaggatc tgcccgctga ttttgtgaaa accacggtac
     9661 tggataacac gccgatccgc tggttctatc gcgcggccag ccaggagtcc gcgcagtggg
     9721 cggcgggcca gaccggggag atccgggtgg acgtggagcg ccgccgggcc agccgggagg
     9781 cggggaacgt ggagcacatc agcggcgaca gcttcatcca gaaggaggcg cggccgctgt
     9841 ttgacgtgaa caccctgcaa cacctgcctg acgggttcgc ggtgatgacc gggctgggcg
     9901 tggcgcggct ggcgttcagc agcccgctgc gggttgagcg ccgggaaatt tcgctgaaaa
     9961 ccttcccggt gctggcgaaa acggacccgc tggcggagta cctgcctccg gccgacggcg
    10021 gcggaccaaa agcggatgat gattttgcgg ggctttactg
//
