LOCUS       NZ_CP066902            10085 bp    DNA     circular CON 30-JUL-2023
DEFINITION  Klebsiella pneumoniae strain XHKP309 plasmid pXHKP309-2, complete
            sequence.
ACCESSION   NZ_CP066902
VERSION     NZ_CP066902.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN17173631
            Assembly: GCF_024346775.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 10085)
  AUTHORS   Zhu,W.
  TITLE     Genome sequence of XHKP309 which was isolated at Dec 14, 2015
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 10085)
  AUTHORS   Zhu,W.
  TITLE     Direct Submission
  JOURNAL   Submitted (28-DEC-2020) Clinical Laboratory, Xinhua Hospital
            Affiliated to Shanghai Jiaotong University School of Medicine, 1665
            Kongjiang Road, Shanghai 200092, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 285.0x
            Sequencing Technology             :: PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 07/30/2023 04:02:15
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.5
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,613
            CDSs (total)                      :: 5,491
            Genes (coding)                    :: 5,365
            CDSs (with protein)               :: 5,365
            Genes (RNA)                       :: 122
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 85
            ncRNAs                            :: 12
            Pseudo Genes (total)              :: 126
            CDSs (without protein)            :: 126
            Pseudo Genes (ambiguous residues) :: 0 of 126
            Pseudo Genes (frameshifted)       :: 50 of 126
            Pseudo Genes (incomplete)         :: 76 of 126
            Pseudo Genes (internal stop)      :: 16 of 126
            Pseudo Genes (multiple problems)  :: 16 of 126
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP066902.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..10085
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="XHKP309"
                     /isolation_source="urine"
                     /host="Homo sapiens"
                     /db_xref="taxon:573"
                     /plasmid="pXHKP309-2"
                     /geo_loc_name="China: Shanghai"
                     /lat_lon="31.21 N 121.45 E"
                     /collection_date="2015-12-14"
                     /collected_by="Xinhua Hospital"
     gene            1..246
                     /locus_tag="JG788_RS27940"
     CDS             1..246
                     /locus_tag="JG788_RS27940"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146442.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_032440458.1"
                     /translation="MTHLKLTPAEEKRLADAFVAQALAMGLKGNKTLPKAVKQQVRERV
                     LRAIQDEREARRAQEMRREKYEATETTFTWQPQRRR"
                     /name="hypothetical protein"
     gene            520..891
                     /gene="tolA"
                     /locus_tag="JG788_RS27945"
     CDS             520..891
                     /gene="tolA"
                     /locus_tag="JG788_RS27945"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001237044.1"
                     /GO_component="GO:0098567 - periplasmic side of plasma
                     membrane [Evidence IEA]"
                     /GO_function="GO:0005215 - transporter activity [Evidence
                     IEA]"
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cell envelope integrity protein TolA"
                     /protein_id="WP_001237044.1"
                     /translation="MRLIPFILLALCSPLLLTACKHSTTQPPKIYTLDKSSKISSYAAA
                     IKTAVEMQMFEPEAYAGKMCTVRISIQRDGTLNSAIAEGGDPKLCKAAISAVTHAKIPP
                     APDENTWQIFKNAPLDFRP"
                     /name="tolA"
     gene            888..1253
                     /locus_tag="JG788_RS27950"
     CDS             888..1253
                     /locus_tag="JG788_RS27950"
                     /inference="COORDINATES: protein motif:HMM:TIGR01352.1"
                     /GO_function="GO:0015291 - secondary active transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TonB family protein"
                     /protein_id="WP_072354022.1"
                     /translation="MKAFTLTVLAAMFLTPVHAIPLKPVTTLQPTYPVQAAAKRIEGQV
                     TATFDILDDGRVDNVSLTGCHLFFRETLTAMRHWLYPAGHPAMRQVINFEFSLKNDGLQ
                     DPRPVTTQKLNDDGCRQ"
                     /name="TonB family protein"
     gene            1428..1706
                     /locus_tag="JG788_RS27955"
     CDS             1428..1706
                     /locus_tag="JG788_RS27955"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014542884.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="CopG family ribbon-helix-helix protein"
                     /protein_id="WP_000093040.1"
                     /translation="MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEK
                     RSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWGTENEQDAPPCHR"
                     /name="CopG family ribbon-helix-helix protein"
     gene            1694..2008
                     /locus_tag="JG788_RS27960"
     CDS             1694..2008
                     /locus_tag="JG788_RS27960"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001136729.1"
                     /GO_function="GO:0008657 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) inhibitor activity
                     [Evidence IEA]; GO:0042803 - protein homodimerization
                     activity [Evidence IEA]"
                     /GO_process="GO:0030541 - plasmid partitioning [Evidence
                     IEA]; GO:0051290 - protein heterotetramerization [Evidence
                     IEA]; GO:0009432 - SOS response [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_071177730.1"
                     /translation="MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKT
                     LPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDREMDQIVIVTVRHQKESGYPGADSL
                     "
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            2172..2600
                     /locus_tag="JG788_RS27965"
     CDS             2172..2600
                     /locus_tag="JG788_RS27965"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001140599.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001140599.1"
                     /translation="MAKTLLNLSQAAQAAGITRRTLYNHVKQGKVTVSRDGKNNPVVDV
                     SELIRVYGNVNIPEKQIPGISHRENTQKNFPQEQLLAMQKELADLRQAVTLMLEDKTSR
                     EEERRQHDDERRKLQAEVDRLTTELTQKKKRFWSGWFS"
                     /name="hypothetical protein"
     gene            2626..2805
                     /locus_tag="JG788_RS27970"
     CDS             2626..2805
                     /locus_tag="JG788_RS27970"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rop family plasmid primer RNA-binding protein"
                     /protein_id="WP_000165970.1"
                     /translation="MTKQEKTALNMAKFIKDQSLLLLEKLNELDMDTPADMCERLHEDA
                     ETLWQVMRDKLGEE"
                     /name="Rop family plasmid primer RNA-binding protein"
     gene            complement(2832..3362)
                     /locus_tag="JG788_RS27975"
     CDS             complement(2832..3362)
                     /locus_tag="JG788_RS27975"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_071177729.1"
                     /translation="MALYMVFIEDVEDKDGERCIMPTSEHLEDMVVLAWQTGAYVFCFV
                     DRAQHLAMMKSIGMYDERLNSDEKATYFFTGENPQWERDKPTGMKLCDYLYRKVERFAI
                     ENGVQVVDAGKCSPEQINAMIEVVSERHGESAVNEKLKAELMREYNSRYFNVPVPELPE
                     DKPARRWWPFGKK"
                     /name="hypothetical protein"
     gene            complement(3369..4100)
                     /gene="mobC"
                     /locus_tag="JG788_RS27980"
     CDS             complement(3369..4100)
                     /gene="mobC"
                     /locus_tag="JG788_RS27980"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobC family replication-relaxation protein"
                     /protein_id="WP_071177728.1"
                     /translation="MTLEQYNVSHAKRQARNAEKTRLTLRWLREELCSTAELVARRLGI
                     AAVQPVYRFLDSLVAKGLLVRAKYPVDGRQVSVWGLTPHGVAFSFDEDEPLTDVIPFQP
                     SRVSAAQLPHRLAVQSLRLSMEGRGATGWRYLHRMALKGMKVPDALAELDGRTVAFEVE
                     RTVKSRRRYQEVVSGYLFNRRANGIDEIWYICPDRPTLVRVQRAILAVDEIVNPQTGEA
                     RKTVELDRERLFACFKFMTTE"
                     /name="mobC"
     gene            complement(4100..4813)
                     /locus_tag="JG788_RS27985"
     CDS             complement(4100..4813)
                     /locus_tag="JG788_RS27985"
                     /inference="COORDINATES: protein motif:HMM:NF024108.2"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TraM recognition domain-containing protein"
                     /protein_id="WP_255054508.1"
                     /translation="MAGIINGGGCLYVIGSMDDEAVIRVQKMLFARCAQIIIARDEFRR
                     WPHASIMLDEIKYLLSKYVLNALGTLRSRDCNLLLAHQSLGDFGQCGQDLPADFVKTTV
                     LDNTPIRWFYRAASQESAQWAAGQTGEIRVDVERRRASREAGNVEHISGDSFIQKEARP
                     LFDVNTLQHLPDGFAVMTGLGVARLAFSSPLRVERREISLKTFPVLAKTDPLAEYLPPA
                     DGGGPKADDDFAGLY"
                     /name="TraM recognition domain-containing protein"
     gene            complement(4801..6093)
                     /locus_tag="JG788_RS27990"
     CDS             complement(4801..6093)
                     /locus_tag="JG788_RS27990"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="type IV secretory system conjugative DNA transfer
                     family protein"
                     /protein_id="WP_255054509.1"
                     /translation="MFNTDSLAWQWHIPELARQIYPWVSWLYREYYSLAGFFLVIGLFF
                     GLAELWAGRMRFVGLSHKARREYADRYKRDNNRTVPFSVLASLDSPGRMVRARRHVWNY
                     AYWLTGAAGLALLGGLVVAVFIESWGETVLRPDLYANADYYLLQPANLFGIAWCAGGLV
                     AGVLLARLLAFLLLDGHFAAADEAVNAKLNQESRRSSQRTGEMTDVRHLHFGEPVPVNA
                     LADFSTEQARKQQAVFLGKDEQGQPVLVPRDTWRKTNIQILGLPGSGKSAMATNALIRC
                     VRDFGDAVVYFDPKGDAWAPHVFRAHCPDFTLLDLRPGKPAQLNLFRDLDQYALKNLLV
                     AGFNLSETGDVADHYRISEQKAAKLIAEQFPQGANIQQVLAAAYALPEALKKDVKGLIT
                     KLENVADLSVLQTDSGIDVAGIDVAVSMWRG"
                     /name="type IV secretory system conjugative DNA transfer
                     family protein"
     gene            <7227..7358
                     /locus_tag="JG788_RS27995"
                     /pseudo=""
     CDS             <7227..7358
                     /locus_tag="JG788_RS27995"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001326446.1"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /name="replication initiation protein"
     gene            complement(7573..7722)
                     /locus_tag="JG788_RS28000"
     CDS             complement(7573..7722)
                     /locus_tag="JG788_RS28000"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891188.1"
                     /GO_component="GO:0019867 - outer membrane [Evidence IEA]"
                     /GO_process="GO:0019835 - cytolysis [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin release lysis protein"
                     /protein_id="WP_032440454.1"
                     /translation="MKKVKTIFLFILIVAGFLLAACQANYIRDVQGGTVAPSSSSELTG
                     IAVQ"
                     /name="colicin release lysis protein"
     gene            complement(7807..8064)
                     /locus_tag="JG788_RS28005"
     CDS             complement(7807..8064)
                     /locus_tag="JG788_RS28005"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891189.1"
                     /GO_function="GO:0015643 - toxic substance binding
                     [Evidence IEA]"
                     /GO_process="GO:0030153 - bacteriocin immunity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin E3-like toxin immunity protein"
                     /protein_id="WP_032440455.1"
                     /translation="MGLKLRLTWFDKKTEEFKGEEYSKDFGDDGSVIESLGMPLKDNIN
                     NGEFDLKKEWVPLLQPFFKNQIKPDVDNCYIAFDYRDGNW"
                     /name="colicin E3-like toxin immunity protein"
     gene            complement(8074..9759)
                     /locus_tag="JG788_RS28010"
     CDS             complement(8074..9759)
                     /locus_tag="JG788_RS28010"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin-like bacteriocin tRNase domain-containing
                     protein"
                     /protein_id="WP_032440457.1"
                     /translation="MSGGDGRGPGNSGLGHNGGQASGNVNGTSGKGGPSSGGGTDPNSG
                     PGWGTTHTPNGDIHNYNPGEFGNGGSKPGGNGGNSGNHSGSSGGGQSSATAMAFGLPAL
                     ATPGAEGLALSVSGDALSAAVADVLAALKGPFKFGLWGIAIYGVLPSEIAKDDPKMMSK
                     IMTSLPADAVTETPASTLPLDQATVRVRQRVVDVVKDERQHIAVVAGRPMSVPVVDAKP
                     TKRPGVFSVSIPGLPSLQVSVPKGVPTAKAPPKGIVAEKGDSRPAGFTAGGNSREAVIR
                     FPKETGQKPVYVSVTDVLTPAQVKQRQEEEKRRQQAWDAAHPEEGLKRDYDKAKAELDA
                     EDKNIATLNSRIASTEKALPGARAAVQEADKKVKEAEANKDDFVTYNPPHEYGSGWQDQ
                     VRYLDKDIQNQNEKLKAAQASLNAMNESLSRDKAALTGAMESRKQKEKKAKDAENKLNE
                     EKNKPRKGTKDYGHDYHPVPKTEDIKGLGELKRGDPKTPKQGGGGKRARWYGDKKRKIY
                     EWDSQHGELEGYRASDGEHLGAFDPKTGKQVKGPDPKRNIKKYL"
                     /name="colicin-like bacteriocin tRNase domain-containing
                     protein"
     BGC             3074..10085
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          6896..7470
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="97.595"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          complement(3373..4100)
                     /name="MOBC"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="93.416"
                     /coverage="100.0"
                     /evalue="1.34e-140"
ORIGIN
        1 atgacgcacc tgaaactgac tcccgctgaa gaaaagcgcc tggcggacgc ctttgtcgct
       61 caggcactgg ccatgggcct gaaagggaac aaaacgctgc caaaggcggt aaaacaacag
      121 gtgcgggaaa gggtgcttcg tgccattcag gacgaacgtg aagccaggcg ggcgcaggaa
      181 atgcgtcggg agaaatacga ggctacggaa accaccttca cctggcagcc acagcgccgc
      241 cggtaagggg tatttaccat aacgtcgcat tgcccgcacc gctcagacgg tctgagggcg
      301 tttccggcgg ctacgggata aaacaggcaa caaaccaccc ggaaaaccgc cggaaacgcg
      361 cccggtaaat tgtaacccgc tgcatgccta tgcacgcaac tgcatggcgg gccgtttggt
      421 gtaaaaacga tacgataagc cgtgtttatg taaatgaacg tggccgtaaa gagtgacaaa
      481 tatacatgta acatttttta ctgacaggtc atcaacccga tgcgtttaat accctttatc
      541 ctgctggcat tgtgcagccc cttactcctg acggcctgta agcattccac cacccagccg
      601 ccgaaaattt atactctgga taagtcatct aaaatcagta gctacgctgc ggccatcaag
      661 accgctgttg aaatgcagat gtttgaacca gaggcctatg cgggaaaaat gtgcaccgtg
      721 cggatatcca tacaacgtga tggcactctg aacagcgcca ttgctgaagg aggagatccg
      781 aaactctgta aagcagcaat atcagccgtt acccacgcca aaattccgcc ggcaccggat
      841 gaaaatacct ggcaaatatt caaaaacgcc cctctggatt tcagaccatg aaagctttta
      901 ctctgacagt gctggcggcc atgttcctca ctccggtaca tgcgatacca ctaaaacccg
      961 taaccacact gcagccaacc tacccggtac aggccgcagc aaaacgcatc gaaggtcagg
     1021 tgaccgccac gtttgatatt ctggacgatg gacgagtgga caacgtgtcg cttaccggct
     1081 gtcacctttt ttttcgggaa acgctgacgg caatgaggca ctggctatat cccgcagggc
     1141 acccggcaat gcgacaggtt ataaattttg aattcagtct gaaaaatgac ggcttacagg
     1201 atccgcgacc agtcaccacc caaaagctca atgatgatgg ttgccgccag taacaggtcc
     1261 tttaacccgc aggctgcaat agtcctggat gatgagtgag cctgtagcag ccctgattag
     1321 tggaagcgaa gctgaaaaat gggcagcaaa agccgtattt ctggcaaata gcgccgccac
     1381 ggattaaagt agtcatgtgt aatacatatg actacaaagg ggcttttatg tcatcagcaa
     1441 catccatcag gctcgatgaa gaacttaagg accggctgaa aacgctggcc gatgaccggc
     1501 accgctcagc gcacgcgcta atgctggagg caatcaccga atacatcgac cgggaagaga
     1561 agcgcagcca gtacctgcgg gacggacagg ccgcatggca gcactatcag gaaacgggtc
     1621 tgcaccttac tgcggaagaa gcggaagcct ggataagtac ctggggaact gagaacgagc
     1681 aggatgctcc gccatgccac aggtaacgat ttccgcgctg gcacagcgcg atttacaacg
     1741 ccttcaggac tttctcaaaa ccaaaaatcg gctggcagcc agaaaaggag gtgaggtgat
     1801 cgtccgggct atccagcaac tgaaaacatt gccagacatt ggccgcccgg tgccgtttct
     1861 gccgctggaa tataaggaac tggtgatcgg gtttggcgac agtggctatg tgatgctcta
     1921 ccgccacgac cgggaaatgg accagattgt gatcgtcacc gtcaggcatc agaaagaatc
     1981 cgggtatccg ggggcagaca gcctctaata accgatgacg ggggcgcaat tcattgcgtg
     2041 gccgtcgccg gtttgacaag cgcagcgcgt cagaaaacca catcctgaac ggaaaaacgg
     2101 gtaaaattca gcgatacatt taccgtgaga aattacacac ctttcacacc cgataaaatc
     2161 aggggtatac agtggcgaaa acattgctca acctttcaca ggcagcacaa gccgcgggca
     2221 ttaccagaag aacgctatac aatcatgtaa aacagggaaa ggttaccgtg tcacgtgacg
     2281 ggaaaaacaa ccctgtcgtg gatgtgtcag aactgatccg tgtatacgga aatgtgaata
     2341 tccctgagaa acaaattccc ggcatttcac accgtgaaaa tacacaaaaa aatttcccac
     2401 aggaacagct tctggcaatg caaaaggaac tggccgatct ccggcaggct gtcaccctga
     2461 tgctggaaga taaaacatcc cgggaagaag aacgccgcca gcacgatgat gagcgccgga
     2521 aactccaggc cgaagtggac agattgacaa cagaactgac acagaagaaa aaacgcttct
     2581 ggtccggctg gtttagctga gaacttaccg aagggaatgg agaacatgac gaagcaggaa
     2641 aaaactgccc tcaatatggc taaattcatt aaggatcagt cgctgctgtt gctggaaaag
     2701 ctgaacgagc tggacatgga taccccggcc gacatgtgcg aacggcttca cgaggatgcg
     2761 gaaacactct ggcaggtgat gcgggataag ctcggggaag aataacagca ccggccatgc
     2821 cggtgctggc gttatttttt gccgaacggc caccaccggc gggcgggttt gtcctccggc
     2881 agttcaggca ccggcacgtt aaaatagcgg ctgttatatt cccgcatcag ctccgctttc
     2941 agcttctcgt tcaccgcgct ttccccgtgc cgctcgctga ccacctcaat catcgcgtta
     3001 atctgctccg gtgagcactt cccggcatca accacctgca caccgttctc gatggcgaac
     3061 cgctccacct ttcgatagag gtaatcacac agcttcattc ctgtgggttt gtcccgttcc
     3121 cattgcggat tttcaccggt gaaaaagtac gtggcttttt cgtcgctgtt gagccgctcg
     3181 tcatacatcc cgatggattt catcatcgcc agatgctggg cccggtcgac aaaacagaaa
     3241 acatacgccc cggtctgcca ggcgagcacc accatgtctt ccagatgctc gctggttggc
     3301 ataatgcagc gctcgccgtc tttgtcttcc acgtcctcaa taaataccat gtacagcgcc
     3361 ataatccctc actccgttgt cataaattta aagcacgcga acagcctctc ccggtccagc
     3421 tccaccgttt tgcgggcctc gccggtctgt ggattcacga tttcatccac cgccagaatc
     3481 gcccgctgta cccggacaag cgtcggccgg tcagggcaga tgtaccagat ttcatcgatg
     3541 ccgttcgccc ggcggttgaa cagatacccg gacaccactt cctgataccg cctgcggctc
     3601 ttgacggtgc gctctacctc aaatgccacc gttctgccgt ccagctccgc cagcgcgtcc
     3661 ggcactttca tccctttcag ggccatacgg tgcaggtacc gccagccggt ggccccccgg
     3721 ccctccatgg agaggcgcag ggactgcacg gccagccggt gcggcagctg cgccgccgac
     3781 acccttgacg gctgaaacgg aataacgtcc gtcagcggct cgtcctcgtc gaacgagaac
     3841 gccaccccgt gcggcgtcag cccccacacg ctgacctgac ggccgtcaac cgggtatttc
     3901 gcccggacca gcagcccttt cgccaccaga ctgtccagga agcggtaaac cggctgtacc
     3961 gccgcaatcc ccagccgtcg cgcaaccagc tccgccgtgg aacacagctc ttcccgcagc
     4021 cagcgcaggg tcagccgtgt tttctccgcg ttccgcgcct gccgcttcgc gtggctgacg
     4081 ttgtactgct ccagtgtcat cagtaaagcc ccgcaaaatc atcatccgct tttggtccgc
     4141 cgccgtcggc cggaggcagg tactccgcca gcgggtccgt tttcgccagc accgggaagg
     4201 ttttcagcga aatttcccgg cgctcaaccc gcagcgggct gctgaacgcc agccgcgcca
     4261 cgcccagccc ggtcatcacc gcgaacccgt caggcaggtg ttgcagggtg ttcacgtcaa
     4321 acagcggccg cgcctccttc tggatgaagc tgtcgccgct gatgtgctcc acgttccccg
     4381 cctcccggct ggcccggcgg cgctccacgt ccacccggat ctccccggtc tggcccgccg
     4441 cccactgcgc ggactcctgg ctggccgcgc gatagaacca gcggatcggc gtgttatcca
     4501 gtaccgtggt tttcacaaaa tcagcgggca gatcctgccc gcactgaccg aagtcgccca
     4561 gcgactggtg cgcgagcagc aggttgcagt cccggctgcg cagcgtcccc agcgcgttca
     4621 gcacgtactt cgacagcaga tatttaatct catcgagcat gatgctcgcg tgcggccacc
     4681 tccggaactc atcccgcgca atgatgattt gcgcgcagcg ggcaaacagc atcttctgca
     4741 cccggatcac cgcctcatcg tccatcgagc cgatgacgta caggcagccg ccgccgttga
     4801 ttatccccgc cacatcgata ccgccacatc gatccccgcc acatcgatac cgctgtccgt
     4861 ctgcaggacg ctcaggtcgg ccacgttctc cagcttggtg atcagcccct tcacgtcctt
     4921 tttcagggcc tccggcaacg cgtacgccgc cgccagcacc tgctgaatgt ttgccccctg
     4981 cgggaactgc tccgcaatca gcttcgccgc tttctgctcg ctgatgcggt agtggtccgc
     5041 cacgtcgccg gtctcactca ggttaaaccc ggcaaccagc agattcttca gggcgtactg
     5101 gtcgagatcg cggaacagat tcagctgcgc cggtttcccc ggccgcagat ccagcagggt
     5161 gaagtccggg cagtgcgccc ggaagacgtg cggcgcccac gcgtcccctt tggggtcgaa
     5221 gtacaccaca gcgtccccga aatcgcgtac gcagcgaatg agcgcgttgg tggccatcgc
     5281 gctcttgccg ctcccgggca ggccgaggat ctgaatattg gtcttgcgcc aggtatcacg
     5341 agggaccagc accggctggc cctgctcatc cttacccaga aacaccgcct gctgtttccg
     5401 ggcctgctcc gtggaaaaat cggccagcgc gttaaccggt accggctccc cgaaatgcag
     5461 gtggcggacg tctgtcattt ctccggtccg ctggctgctg cgccggctct cctgattcag
     5521 tttcgcgttc accgcctcgt cagcggccgc aaaatgacca tcaagcagca ggaacgccag
     5581 cagccgcgcc agaaggacgc cggcgacaag ccctccggca caccaggcta tcccgaacag
     5641 gttagccggc tgcagcaggt aataatctgc gttcgcatag aggtccgggc gcaggacggt
     5701 ttctccccag ctctcgataa acacggcgac aaccagcccc cccagaaggg ccagaccggc
     5761 agcgccggtc agccagtacg cgtagttcca gacatgtcgc cgtgccctga ccatccgccc
     5821 gggtgaatcc agcgaggcca gcaccgaaaa tggcacagtc cggttattat cgcgcttata
     5881 gcgatcggca tactcccgcc gcgccttatg gctcagcccc acaaaacgca ttcggccggc
     5941 ccagagttca gccagaccga aaaacaggcc gataaccaga aaaaaaccgg ccagactgta
     6001 atactcccgg tacagccagc tgacccacgg gtaaatctgc cgggccagct ccgggatatg
     6061 ccactgccag gcaagcgaat ccgtattaaa catgcaatct ctctccttca gacgacgggt
     6121 ttaccggcgt gatgcgcagc ccccgctgca caagccgcgg acatgcccca aggcatggcg
     6181 gcggcggtca cgtccgtggt gattgcgttc agctttcacc gcggaggcca gcctctttcc
     6241 gccccatgcg gaaaaggcgc agccccggag gaacaacgag cacgccccag cgtgtgagag
     6301 gaaaaggcgg caccccagtg cggtcttttc cggtgttccg gcccccgtca gagttcgcca
     6361 tagcgagcgg ctgaccaccc gcaaaatcag gagcagcttt gctgcttcgt caggtgcgtc
     6421 cagcaccgtg gatttttgtg ggtggtcagg cgtgagcctg acgggggccg ggtgaatttc
     6481 tggcgtggcc ggcgtccagc cggacagagc cagaaagagg ggaaaagacc gtgcgtcggt
     6541 ggcgtccagc cagcgtaagc aaggtctttt cccctgaagt cagccacgcc ccagcgggga
     6601 tgacttgcat ttctccgcaa ggagaaaaaa gcaacagaga taggttaacg taaaatgttc
     6661 agcgaaaaac cgacatggtt cacctatcct gataattgat cgtcagggaa tagaaagact
     6721 taatcagggg acaatatccc acatcagcgc gtccggtgac cgtcttgcag gtgccgggga
     6781 aattgcgcct cctcgctcac tcggtcgcta cgctccgggc gtgagactgc ggcgggcgct
     6841 gcggacacat acaaagttac ccacagattc cgtggataag caggggacta acatgtgagg
     6901 caaaacggca gggccgcgcc ggtggcgttt ttccataggc tccgccctcc tgccagagtt
     6961 cacataaaca gacgcttttt cggtgcatct gtgggagccg tgaggctcaa ccatgaatct
     7021 gacagtacgg gcgaaacccg acaggactta aagatcccca cggtttccgg taggtcgctc
     7081 cctcttgcgc tctcctgttc cgaccctgcc gtttaccgga tacctgtccg ccgttctccc
     7141 ttcgggaagt gtggcgcttt ctcatagctc acacactggt atctcggctc ggtgtaggtc
     7201 gttcgctcca agctgggctg taagcagaac tccccgttca gcccgactgc tgcgccttat
     7261 ccggtaactt cacttgagtc caacccggaa agcacgcaaa aacgccactg gcagcagcca
     7321 ttggtaactg ggagttcgca gaggatttgt ttagctaaac acgcggttgc tcttgaagtg
     7381 tgcgccaaag tccggctaca ctggaaggac agatttggtt gctgtgctct gcgaaagcca
     7441 gttaccacgg ttaagcagtt ccccaactga cttaaccttc gatcaaacca cctccccagg
     7501 tggttttttc gtttacaggg caaaagatta cgcgcagaaa aaaaggatct caagaagatc
     7561 ctttgatctt ttctactgaa ccgcgatccc cgtcagttca gaggaggacg atggtgccac
     7621 cgttccgccc tgaacatccc ggatataatt tgcctgacat gcggccagaa gaaagccagc
     7681 aacaatcaat ataaaaagaa aaatagtctt tacctttttc atatactttc cctgtattta
     7741 aagactccgg cattcatccc tgaacaccgg aagtcagtat ttcaaatcat ccttgataat
     7801 tttttgttac cagttaccgt cccgataatc aaaagctata taacaattat ccacatcagg
     7861 ttttatttga tttttaaaaa atggctgtag taaaggaacc cattctttct tcaaatcaaa
     7921 ctcaccatta ttaatattat cctttaaagg cattcccaag ctttcaatga cagaaccatc
     7981 gtcaccaaag tctttagaat actcttcccc tttaaactct tcagttttct tatcaaacca
     8041 tgtcaaacgt aatttaagcc ccatatttac ctctcaaaga tattttttaa tgttccgttt
     8101 tggatctggc cctttaacct gcttacccgt tttgggatca aatgcgccta ggtgttcgcc
     8161 atcactggca cgataccctt caagctcacc gtgctgggaa tcccattcat aaattttacg
     8221 ttttttatcg ccataccatc gggcccgctt accaccacca ccttgtttag gtgttttagg
     8281 atcacctcgc tttaactctc caagtccctt tatgtcttct gttttaggta ctggatgata
     8341 atcatggccg tagtctttag tccccttgcg aggcttgttc ttttcctcat ttaacttatt
     8401 ttctgcatcc ttcgcttttt tctccttttg tttccggctc tccatcgccc cggtaagtgc
     8461 agccttatct ctggataagg attcattcat tgcgtttaaa gatgcctgag ccgcttttaa
     8521 tttctcattc tgattctgaa tatccttatc aagatagcga acctgatcct gccacccgga
     8581 gccatattca tgaggcgggt tataagtcac aaaatcatct ttatttgcct ctgcctcttt
     8641 taccttttta tcggcttcct gaacagcagc ccttgcaccg gggagcgcct tctctgtcga
     8701 tgcaatgcgg ctgtttaagg tcgcaatatt tttatcttcg gcatccagct cagctttcgc
     8761 tttatcatag tctcttttca gcccctcttc cggatgagcg gcgtcccatg cctgctggcg
     8821 acgcttttct tcctcctgac gctgttttac ctgtgccggg gtaagaacat ctgtcaccga
     8881 cacataaacc ggcttctgtc cggtctcttt cgggaaacga ataacggcct cacgggagtt
     8941 accaccggct gtaaaaccag ccggacgtga atcacctttt tcagcaacaa tgccttttgg
     9001 cggggctttc gctgtcggaa cacctttcgg tacgctcacc tgcagagacg ggagacccgg
     9061 aatcgacaca ctgaataccc ccggacgttt tgtcggtttc gcatccacca cagggacact
     9121 cattggccga cctgcgacaa ccgcaatatg ctgccgctca tccttcacca catccacaac
     9181 ccgttgtctg acacgaaccg tcgcctggtc cagtggtaaa gtacttgccg gagtctccgt
     9241 caccgcatcg gccggtaatg acgtcataat ttttgacatc attttcggat catcttttgc
     9301 aatctcagaa ggcagcacac cgtagatcgc aatcccccac agaccaaact taaacggccc
     9361 cttcagggca gccagcacat cagcaacggc ggccgacaac gcatcgccgg aaactgataa
     9421 agccagtcct tcagcccccg gagtagccag ggcaggcaga ccgaaggcca tcgcagtggc
     9481 cgaagactgt ccgccaccag agctaccgct atgattgccg ctgttaccac cattaccacc
     9541 gggtttactc ccgccgttac caaactcccc cggattatag ttatgaatat ctccattcgg
     9601 cgtatgcgtc gtaccccagc ccggcccgct gtttggatcc gtaccaccac ctgatgaagg
     9661 gccaccttta ccagacgtac cgttcacatt cccactggcc tgaccaccat tatgtcccag
     9721 acctgaatta cccggacctc gaccgtctcc accactcata ccgttttcct ctttgacatt
     9781 taaaacaata aattaaagcc aacatactgt acatatacac agtataatta ttaccttact
     9841 cctcccgttt tcaggtgtca atatatgaga ttagttctca tcttcaggca caaaaaagcg
     9901 cccggagcca cctgtaagca gatcgcgtct tttcccgaaa atttctcatg gcaacaaatt
     9961 ttattattta agacattcat cacacttaca tttcagatgg tatagacaca tctgaaagct
    10021 aactggcatg aggagaggac ctgcggttaa actgttcggg aaacctgaga cgcccggagg
    10081 ccact
//
