LOCUS       NZ_CP065753            24353 bp    DNA     circular CON 18-AUG-2023
DEFINITION  Enterococcus faecium strain 18-465 plasmid p18-465_1, complete
            sequence.
ACCESSION   NZ_CP065753
VERSION     NZ_CP065753.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN16988100
            Assembly: GCF_018516845.1
KEYWORDS    RefSeq.
SOURCE      Enterococcus faecium
  ORGANISM  Enterococcus faecium
            Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
            Enterococcus.
REFERENCE   1  (bases 1 to 24353)
  AUTHORS   Dejoies,L., Sassi,M., Schutz,S., Moreaux,J., Zouari,A., Potrel,S.,
            Collet,A., Lecourt,M., Auger,G. and Cattoir,V.
  TITLE     Genetic features of the poxtA linezolid resistance gene in human
            enterococci from France
  JOURNAL   J Antimicrob Chemother 76 (8), 1978-1985 (2021)
   PUBMED   33895846
REFERENCE   2  (bases 1 to 24353)
  AUTHORS   Dejoies,L., Sassi,M., Schutz,S., Zouari,A., Potrel,S., Collet,A. and
            Cattoir,V.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-DEC-2020) Rennes1 University, U1230, 2 avenue du
            Professeur Leon Bernard, Rennes 35043, France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: DEC-2020
            Assembly Method                   :: Unicycler v. v0.4.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 250x
            Sequencing Technology :: Oxford Nanopore MiniION; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 08/18/2023 05:34:15
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,530
            CDSs (total)                      :: 2,440
            Genes (coding)                    :: 2,340
            CDSs (with protein)               :: 2,340
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 100
            CDSs (without protein)            :: 100
            Pseudo Genes (ambiguous residues) :: 0 of 100
            Pseudo Genes (frameshifted)       :: 39 of 100
            Pseudo Genes (incomplete)         :: 50 of 100
            Pseudo Genes (internal stop)      :: 24 of 100
            Pseudo Genes (multiple problems)  :: 11 of 100
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP065753.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..24353
                     /organism="Enterococcus faecium"
                     /mol_type="genomic DNA"
                     /strain="18-465"
                     /isolation_source="Digestive"
                     /host="Homo sapiens"
                     /db_xref="taxon:1352"
                     /plasmid="p18-465_1"
                     /geo_loc_name="France: Bordeaux"
                     /lat_lon="44.8305 N 0.6029 W"
                     /collection_date="2018-08"
                     /collected_by="NRC for Enterococci"
     gene            complement(55..735)
                     /locus_tag="I8F49_RS12355"
                     /old_locus_tag="I8F49_12325"
     CDS             complement(55..735)
                     /locus_tag="I8F49_RS12355"
                     /old_locus_tag="I8F49_12325"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="WP_013646119.1"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASPTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            complement(972..1433)
                     /locus_tag="I8F49_RS12360"
                     /old_locus_tag="I8F49_12330"
     CDS             complement(972..1433)
                     /locus_tag="I8F49_RS12360"
                     /old_locus_tag="I8F49_12330"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000389746.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_002305240.1"
                     /translation="MEDLGSKLRELRVKKGYTQEYVARKFNVTRQTISKWENNKTTPDI
                     ETLKKICEFYSTNINSILNEDNSKNKKNNLLVLTAIIFNIFVTILGLFELIQMNFFSFT
                     HGIFTWFALSGLIVIDILNYFYIYYSYLKNEKFFYTMFFPLVILIILLS"
                     /name="helix-turn-helix domain-containing protein"
     gene            1566..1940
                     /locus_tag="I8F49_RS12365"
                     /old_locus_tag="I8F49_12335"
     CDS             1566..1940
                     /locus_tag="I8F49_RS12365"
                     /old_locus_tag="I8F49_12335"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000713874.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="lactococcin 972 family bacteriocin"
                     /protein_id="WP_002305242.1"
                     /translation="MKKFLCLSALMGVLLTSGGIASATEALNLDVPEDHTAIYGGGMEA
                     TEEGFSSSKLRYAAGGGDFNCGVNGFKVYANYYHARAKHSATAKNGRGGQVRSVQKAGV
                     RAYATCNATLTGNTGWWNVY"
                     /name="lactococcin 972 family bacteriocin"
     gene            1994..2539
                     /locus_tag="I8F49_RS12370"
                     /old_locus_tag="I8F49_12340"
     CDS             1994..2539
                     /locus_tag="I8F49_RS12370"
                     /old_locus_tag="I8F49_12340"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_230307298.1"
                     /translation="MLKKINAVLSLFVCITILFFSTNVINGIKTSEALYKNTAEIHMQY
                     KDDMDFNSYINALYEISTQENINISQYSFTAVNQLTILATNPNANKHWKFSKKNILARN
                     DSKVHYTNNKNSKYQLKLPNNFLNINIYPFSHVENIGLSEILYVQGNSNKLIPVLKKYG
                     TPTISNMVLLQSFKSTIK"
                     /name="hypothetical protein"
     gene            2577..3257
                     /locus_tag="I8F49_RS12375"
                     /old_locus_tag="I8F49_12345"
     CDS             2577..3257
                     /locus_tag="I8F49_RS12375"
                     /old_locus_tag="I8F49_12345"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="WP_013646119.1"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASPTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            3261..3791
                     /locus_tag="I8F49_RS12380"
                     /old_locus_tag="I8F49_12350"
     CDS             3261..3791
                     /locus_tag="I8F49_RS12380"
                     /old_locus_tag="I8F49_12350"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002510381.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_125276271.1"
                     /translation="MDTVRDFILYLKLCNRTVTRYILKQKTLGLFFLALTPVIDLILLI
                     TTGIDLMNGATAATPHAIAAVYISVSLVFGKSMINWADDRFGYYVMKQGPKPYKPVGLA
                     YSKNYAKSWLKHLLSYIIGTGILHLIIFLINDKSRTEAMDNVIHVWTIVIIIDLIICIS
                     YFVWPPKNTESKL"
                     /name="hypothetical protein"
     gene            3928..4185
                     /locus_tag="I8F49_RS12385"
                     /old_locus_tag="I8F49_12355"
     CDS             3928..4185
                     /locus_tag="I8F49_RS12385"
                     /old_locus_tag="I8F49_12355"
                     /inference="COORDINATES: protein motif:HMM:NF013677.2"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0004803 - transposase activity [Evidence IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /protein_id="WP_013330744.1"
                     /translation="MTKYSESFKEMIVDLANNGTKAKDLSSEYGISEAAIYKWKKLYTK
                     DSKTGVNEKQMQTLRKEIKQLKLENEILRKAAAIFAQDPL"
                     /name="transposase"
     gene            <4539..4892
                     /locus_tag="I8F49_RS12395"
                     /pseudo=""
     CDS             <4539..4892
                     /locus_tag="I8F49_RS12395"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019169163.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /name="helix-turn-helix domain-containing protein"
     gene            5296..6705
                     /gene="fexB"
                     /locus_tag="I8F49_RS12400"
                     /old_locus_tag="I8F49_12365"
     ARG             5297..6702
                     /name="fexB"
                     /gene="fexB"
                     /gene_name="chloramphenicol/florfenicol efflux MFS
                     transporter FexB"
                     /tool="amrfinderplus"
                     /drug_class="PHENICOL"
                     /identity="100.0"
                     /coverage="100.0"
     gene            complement(7035..7352)
                     /locus_tag="I8F49_RS12405"
                     /old_locus_tag="I8F49_12370"
     CDS             complement(7035..7352)
                     /locus_tag="I8F49_RS12405"
                     /old_locus_tag="I8F49_12370"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_181401625.1"
                     /translation="MFSYYQNNLYGSELVEPDLNNPYQENTKILDNKATQKQPALSDQY
                     KALHDKLKEPGANKQQIQEQLNKVKIEISQKTQQQLKDFAKANPDLKQPRVKKEQQALQ
                     R"
                     /name="hypothetical protein"
     gene            7442..8122
                     /locus_tag="I8F49_RS12410"
                     /old_locus_tag="I8F49_12375"
     CDS             7442..8122
                     /locus_tag="I8F49_RS12410"
                     /old_locus_tag="I8F49_12375"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="WP_013646119.1"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASPTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            9081..10709
                     /gene="poxtA"
                     /locus_tag="I8F49_RS12415"
                     /old_locus_tag="I8F49_12380"
     ARG             9082..10706
                     /name="poxtA"
                     /gene="poxtA"
                     /gene_name="ABC-F type ribosomal protection protein PoxtA"
                     /tool="amrfinderplus"
                     /drug_class="PHENICOL/OXAZOLIDINONE"
                     /identity="100.0"
                     /coverage="100.0"
     gene            10763..11443
                     /locus_tag="I8F49_RS12420"
                     /old_locus_tag="I8F49_12385"
     CDS             10763..11443
                     /locus_tag="I8F49_RS12420"
                     /old_locus_tag="I8F49_12385"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="WP_001015311.1"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            11571..12530
                     /locus_tag="I8F49_RS12425"
                     /old_locus_tag="I8F49_12390"
     CDS             11571..12530
                     /locus_tag="I8F49_RS12425"
                     /old_locus_tag="I8F49_12390"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558064.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS30-like element IS1252 family transposase"
                     /protein_id="WP_000222577.1"
                     /translation="MTYTHLTTDELVMIESYYHQNIKIVKIAEYLKRSRTPIYNVINFL
                     KEGHTALEYYQQYKENKKRCGRRNIVLPKKQQSYIKEKIAQGWTPDVIIGRKEKPISCS
                     VRTLYRQFKEKVFDESTLPMKGKRKPNGHQERRGKQAFKRNIVERETDYPTFKEEFGHI
                     EGDTIVGIHHKSAVITLVERLSKIIITLKPEGRKAIDIENTLNHWFGSIPRHLFKSITF
                     DCGKEFSNWKALSNQHDIAIYFADPGTPSQRALNENSNGLLRKDGLPKNMDFNQVDQAF
                     ISSVANKRNNIPRKSLDYQTPLEVFMSYMNEDILSSLI"
                     /name="IS30-like element IS1252 family transposase"
     gene            complement(12963..13535)
                     /locus_tag="I8F49_RS12430"
                     /old_locus_tag="I8F49_12395"
     CDS             complement(12963..13535)
                     /locus_tag="I8F49_RS12430"
                     /old_locus_tag="I8F49_12395"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000170424.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_000170424.1"
                     /translation="MTKYGYARVSTASQSTKEQIQQLLENGVEKKNIFSEKFTGTKRDR
                     PKFNQLLAGLKPGDEIVVTKLDRFARNTREALEIIEPLLDDNVTIKVLNLGTIENTSMG
                     RMVTRTLLSVAEMERDMIVERTQEGKMFARKNNPNFREGRPKATITPKKRHAYELLTSG
                     KSYKEVEAITGFSRSTLFRIKKKIEES"
                     /name="recombinase family protein"
     gene            complement(13551..14156)
                     /locus_tag="I8F49_RS12435"
                     /old_locus_tag="I8F49_12400"
     CDS             complement(13551..14156)
                     /locus_tag="I8F49_RS12435"
                     /old_locus_tag="I8F49_12400"
                     /EC_number="2.7.7.108"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016176895.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="protein adenylyltransferase Fic"
                     /protein_id="WP_000599739.1"
                     /translation="MILENKLGLTNQVELAKVEEKLSKQKAKELYDCGKINEIEVGTFK
                     GLSEIHEFLFSDIYDFAGKIRSVNIAKGNFRFAPVMYLEHSLQHIDQMPQTSFEEIIKK
                     YVEMNIAHPFREGNGRSTRIWLDLILKEELQKVVDWNLIDKADYLSAMERSPINDLEIR
                     YLISNALTDKIDDRELYMKGIDVSYFYEGYSEYTIDDL"
                     /name="protein adenylyltransferase Fic"
     gene            complement(14354..15034)
                     /locus_tag="I8F49_RS12440"
                     /old_locus_tag="I8F49_12405"
     CDS             complement(14354..15034)
                     /locus_tag="I8F49_RS12440"
                     /old_locus_tag="I8F49_12405"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="WP_001015311.1"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASTTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            <15066..15779
                     /locus_tag="I8F49_RS12445"
                     /old_locus_tag="I8F49_12410"
                     /pseudo=""
     CDS             <15066..15779
                     /locus_tag="I8F49_RS12445"
                     /old_locus_tag="I8F49_12410"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018368130.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="C40 family peptidase"
                     /name="C40 family peptidase"
     gene            15776..>16231
                     /locus_tag="I8F49_RS12450"
                     /old_locus_tag="I8F49_12415"
                     /pseudo=""
     CDS             15776..>16231
                     /locus_tag="I8F49_RS12450"
                     /old_locus_tag="I8F49_12415"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989471.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="conjugal transfer protein"
                     /name="conjugal transfer protein"
     gene            16307..16987
                     /locus_tag="I8F49_RS12455"
                     /old_locus_tag="I8F49_12420"
     CDS             16307..16987
                     /locus_tag="I8F49_RS12455"
                     /old_locus_tag="I8F49_12420"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_064305258.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS1216 family transposase"
                     /protein_id="WP_013646119.1"
                     /translation="MNHFKGKQFQQDVIIVAVGYYLRYNLSYREVQEILYDRGINVSHT
                     TIYRWVQEYGKLLYQIWKKKNKKSFYSWKMDETYIKIKGKWHYLYRAIDADGLTLDIWL
                     RKKRDTQAAYAFLKRLVKQFDEPKVVVTDKAPSITSAFKKLKEYGFYQGTEHRTIKYLN
                     NLIEQDHRPVKRRNKFYRSLRTASPTIKGMEAIRGLYKKTRKEGTLFGFSVCTEIKVLL
                     GIPA"
                     /name="IS6-like element IS1216 family transposase"
     gene            17299..18339
                     /locus_tag="I8F49_RS12460"
                     /old_locus_tag="I8F49_12425"
     CDS             17299..18339
                     /locus_tag="I8F49_RS12460"
                     /old_locus_tag="I8F49_12425"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_080341602.1"
                     /translation="MKKASKFVYKIQKNYKTFIIAPYNYATIQENNKEFFIGQKVYPNF
                     EDYVSQPAGAGICVDLNYLKYYNPISFEESTDLNLINSDPLTTYILVPKKYKEYAKMIE
                     KNYLEDIQFRLEDSPPQAPYKNPNLKNLKIKLIFVNNNQKYFSFNTLYGKAKDNYTITD
                     PIVRVINPEITESLFWGNILTSDGGLFFDQKHTSNQNFFNQINPYIKEFNLENIINFSY
                     SVFQETGELLSQKKVNKLNAYLQYLLILGLFIIINFQMIFVSFTINSKKIALKKIFGYS
                     PISQVLDLCLLPFTIELFATMCFQLIFSKNTYLYFIIFMIFLINLITSIIIYKKNSFKY
                     FKENIL"
                     /name="hypothetical protein"
     gene            18336..18956
                     /locus_tag="I8F49_RS12465"
                     /old_locus_tag="I8F49_12430"
     CDS             18336..18956
                     /locus_tag="I8F49_RS12465"
                     /old_locus_tag="I8F49_12430"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002303561.1"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]; GO:0005524 - ATP binding [Evidence IEA];
                     GO:0016887 - ATP hydrolysis activity [Evidence IEA];
                     GO:0042626 - ATPase-coupled transmembrane transporter
                     activity [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_002303561.1"
                     /translation="MILSVENFTLSINKKKIKQNWNFSISEKDFIIVTGKSGSGKTTLL
                     NNLSLIDKQYTGNLFYFEKKVSKHDIQRLRRNHISYLFQNYALLENQTVQYNFELAKKF
                     NSNISNDHIYNLLTDFSLPKDILKEKIFLLSGGEQQRIALIRNMLKPFDILFADEPTGN
                     LDKENSTFIMNFLKNLTEKEKKAVVLVTHDLNVLNYGTNIIEL"
                     /name="ABC transporter ATP-binding protein"
     gene            19070..19207
                     /locus_tag="I8F49_RS12470"
                     /old_locus_tag="I8F49_12435"
     CDS             19070..19207
                     /locus_tag="I8F49_RS12470"
                     /old_locus_tag="I8F49_12435"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002303562.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002303562.1"
                     /translation="MILLKKEYEKFYDRLIYSLQLPKKLNRQLQKTYETKSTEEWESYC
                     "
                     /name="hypothetical protein"
     gene            19649..20029
                     /gene="mobC"
                     /locus_tag="I8F49_RS12475"
                     /old_locus_tag="I8F49_12440"
     CDS             19649..20029
                     /gene="mobC"
                     /locus_tag="I8F49_RS12475"
                     /old_locus_tag="I8F49_12440"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002348702.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="plasmid mobilization relaxosome protein MobC"
                     /protein_id="WP_002317440.1"
                     /translation="MSEQNQNLASNSSKKYTYRSEPKQISFRVSESEFAKLKQSAEALQ
                     MSVPAFVKAKAQNARLVTPKVAPDIAQAIARDLAKAGGNINQIAKWCNTHQHDVASGDA
                     QRLSENLKIMQKELQKIWQQLR"
                     /name="mobC"
     gene            20011..20925
                     /locus_tag="I8F49_RS12480"
                     /old_locus_tag="I8F49_12445"
     CDS             20011..20925
                     /locus_tag="I8F49_RS12480"
                     /old_locus_tag="I8F49_12445"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002340563.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="relaxase/mobilization nuclease domain-containing
                     protein"
                     /protein_id="WP_002340563.1"
                     /translation="MATIKVSRTTSCSRAINYAEPRATIKTGINCDVDYAKSEMKQIRM
                     LYGKDDRVQAHLLIQSFRPGEITAEKANQLGAEYAKKIAPDHQTAIYTHTDKDHIHNHI
                     VINSVNLETGKKFQAHGQAFLNKCYDLNDEICLAHNLPITERGKKPEKRTMSEIKLKEK
                     NEPVWKDEIRIAIDQTMKNKKTRTYDQFCNSLKTLGIHCFNRGKNFTYELIHKKKKVRS
                     NRLGKDYEKETILHELDRRERTYNQQRTNELRRARASIRETAEEVRREQRTLTPEQPEI
                     RPARRNHEQHVERGTDHQQELSL"
                     /name="relaxase/mobilization nuclease domain-containing
                     protein"
     gene            20885..21163
                     /locus_tag="I8F49_RS12825"
     CDS             20885..21163
                     /locus_tag="I8F49_RS12825"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002351557.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002348700.1"
                     /translation="MKEEQTTNKNYRSKTLKDIENEIKKQRAFLVPYTQERIQTTIDLQ
                     VKKLHQELLDQRNKEQKKVLIQRSLDFLAPLCCLVLTLFAFWLVWGG"
                     /name="hypothetical protein"
     gene            21165..21854
                     /locus_tag="I8F49_RS12485"
                     /old_locus_tag="I8F49_12450"
     CDS             21165..21854
                     /locus_tag="I8F49_RS12485"
                     /old_locus_tag="I8F49_12450"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002298772.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002298772.1"
                     /translation="MAFYLPYLLIFVSISGSIWLIYKIFQTRYSLKGSKIRFKRFFFLG
                     CIFSLIIVSSGLFGVLEGNKRVSRSILLGNVTQKYESARDKKKKEQALAQKMEEFTTCY
                     EEMNDIFVNQEKRLTDKNMEKLTRLYQNLPEKQQKEVQDNYERTKKDVQYVKDTKIEEA
                     CSDLFGDTNPWFASEEEKKEKQQSVTYERYEILLQQATNMQNPTKKETALNYLKSVKEW
                     LDQQQQN"
                     /name="hypothetical protein"
     gene            complement(21975..22061)
                     /locus_tag="I8F49_RS12490"
                     /old_locus_tag="I8F49_12455"
     CDS             complement(21975..22061)
                     /locus_tag="I8F49_RS12490"
                     /old_locus_tag="I8F49_12455"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018113589.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type I toxin-antitoxin system Fst family toxin"
                     /protein_id="WP_110300541.1"
                     /translation="MFELFICPLLVGVCVSLFSYWLNNRNKK"
                     /name="type I toxin-antitoxin system Fst family toxin"
     gene            22706..23443
                     /locus_tag="I8F49_RS12495"
                     /old_locus_tag="I8F49_12460"
     CDS             22706..23443
                     /locus_tag="I8F49_RS12495"
                     /old_locus_tag="I8F49_12460"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015060391.1"
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006270 - DNA replication initiation
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /protein_id="WP_002305239.1"
                     /translation="MSNDIVRYNNGLNSVPLRKFTPIDMDLFWGICSKMKRKGTKEEIF
                     TFKQIKELIDYNINARGDRFANDLIKMSKKIITLSFIYEDEKTYEQLNLFQKFKIDKVN
                     ETLLIKVSEEFEYILNSIGTNFTRFELENMTNLKSSYVKELYRQLMAHKDRRSKKGHWF
                     VKIEDFRALLAIPESYRMRDIDKQIFAQAKKEFLNVNSTHPAIFKTFEIKKIKAYKGNK
                     IGSLQIYFEENIPSITLDNWLEK"
                     /name="replication initiation protein"
     gene            23471..24010
                     /locus_tag="I8F49_RS12500"
                     /old_locus_tag="I8F49_12465"
     CDS             23471..24010
                     /locus_tag="I8F49_RS12500"
                     /old_locus_tag="I8F49_12465"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002292473.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF536 domain-containing protein"
                     /protein_id="WP_002289340.1"
                     /translation="MQPKETFTIKELSELFEISRQAISKHVDKLDPSLLAKNERGYKVV
                     LRSGVLQLASNLGNQRLLYRLHEYEQENDKNVYISSKNVIVNELLDKLREENEFLREQL
                     SLKEQNNSNMQKLLDQQQQLTLQANQQIEKLQEQLQLAYTEETPEDESTTILSEETESI
                     EKHTKKKKQKWWQLWK"
                     /name="DUF536 domain-containing protein"
     gene            24026..24196
                     /locus_tag="I8F49_RS12505"
                     /old_locus_tag="I8F49_12470"
     CDS             24026..24196
                     /locus_tag="I8F49_RS12505"
                     /old_locus_tag="I8F49_12470"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002322958.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_002292472.1"
                     /translation="MTRKNLLFGSILLGILGFSPMLLSVINKGNKHGELKLNPNYYNSP
                     NEELFVKETDK"
                     /name="hypothetical protein"
     BGC             1..6940
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          22707..23443
                     /name="rep_cluster_1742"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          20012..20922
                     /name="MOBP"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="99.342"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 ggttctgttg caaagtttta aataaagaat aaaatccctt acggtatcta taatttaagc
       61 tgggattccc aataatacct tgatttcagt acagaccgaa aacccgaaga gagtgccttc
      121 ttttcgggtt ttcttatata atcctcggat ggcttccatg cctttaatcg tgggtgaggc
      181 agtgcgtaaa cttcgataga atttattgcg tctctttact ggacgatggt cttgttcaat
      241 caaattattc aggtatttaa tggtacgatg ttctgtccct tgataaaagc cgtattcttt
      301 tagtttctta aaggcacttg taatagaggg ggctttatct gtgactacaa ccttcggttc
      361 atcaaactgc ttcactaacc gcttaagaaa agcataggct gcttgtgtgt cccgtttttt
      421 acgtaaccaa atatccaagg ttaaaccatc tgcatcgatg gctcgataca aataatgcca
      481 ttttccttta attttgatgt acgtttcatc cattttccat gaataaaagg attttttatt
      541 tttctttttc caaatttgat agagtagttt gccatattct tgcacccaac gataaatcgt
      601 cgtatgagaa acgttaatgc cacgatcata taagatttct tgaacttcac gatagctaag
      661 gttataacga agatagtagc ccacggctac aataatcaca tcctgctgaa attgctttcc
      721 tttaaaatga ttcatcgtca ttcctcctgc tatctttttc tattattcta ccttatttga
      781 tagtagattt aaaactttgc aacagaaccg aattagatat agataaccgc gaaaaatcaa
      841 gctttagaaa gttgctttta gctagaccaa ttaaaaatca caaagtgagc gtctctatcc
      901 attggtagag gggctacttg gcatagtcga cattatgtca actatgcaat taaataacta
      961 actacttcat attagcttaa taaaataatc aaaataacta gggggaaaaa cattgtataa
     1021 aaaaattttt cattttttaa ataagaatag taaatataaa aataatttaa gatatctatt
     1081 actattaatc cagatagagc aaaccaagta aatattccat gtgtaaagct aaaaaaattc
     1141 atttgaatca attcaaataa acctaatata gtaacaaata tattaaaaat aatagctgtc
     1201 aataccagta aattattttt tttatttttt gaattatctt catttaaaat agaatttatg
     1261 ttagtactat aaaattcaca aatttttttt agtgtctcta tatctggtgt tgttttgtta
     1321 ttttcccact ttgaaatagt ttgacgtgta acgttaaatt ttcttgccac atattcttga
     1381 gtataccctt ttttcactct taattctctt agcttagatc ctaaatcctc cattttttct
     1441 cctatgtaaa cgattattta cataaaattt tatcataaaa atactaacgc gccaaaaaag
     1501 ttctttattt tataaaacac actaaaataa aataattcta gtaaaaaaga taggagaaat
     1561 aagttatgaa aaaattttta tgtctttctg ctttaatggg tgtcttatta actagtggag
     1621 gaatagctag tgccacagaa gctttaaatc tagatgtacc cgaagaccat accgccattt
     1681 acggaggagg aatggaagct acagaagaag gattttcttc tagtaaattg agatatgctg
     1741 ctggcggcgg ggatttcaac tgtggggtta atggatttaa agtttatgca aattactacc
     1801 atgctagagc taaacatagt gcaacagcta aaaatggacg aggcggtcaa gtacgatcag
     1861 ttcagaaagc tggagtaaga gcttatgcaa catgcaatgc cacacttact ggaaatactg
     1921 gttggtggaa tgtttattaa aaaagagagt ttaaactctc ttttttattt acatttgaaa
     1981 ggaaattcaa aatatgttaa aaaaaataaa cgctgtttta tcactttttg tctgcattac
     2041 aatactattt ttttctacta atgttataaa tggtataaag acttctgaag cgctatataa
     2101 aaataccgct gaaattcata tgcaatataa agatgatatg gactttaaca gttatataaa
     2161 cgctttgtat gaaatatcta cacaagaaaa tattaatatt tctcaatata gttttactgc
     2221 tgttaaccaa ctaactattc ttgctacaaa ccctaacgct aacaaacact ggaaattttc
     2281 taaaaaaaat atattagcaa gaaacgattc taaagtccat tatactaata acaaaaattc
     2341 taagtaccaa ttaaaacttc caaataattt tttaaatata aatatttatc ctttttctca
     2401 tgtggaaaat attggattaa gtgaaatatt atatgtacaa ggaaactcaa acaaattaat
     2461 tcctgtactg aaaaaatatg gaacacctac tatttccaat atggttctgt tgcaaagttt
     2521 taaatctact atcaaataag gtagaataat agaaaaagat agcaggagga atgacgatga
     2581 atcattttaa aggaaagcaa tttcagcagg atgtgattat tgtagccgtg ggctactatc
     2641 ttcgttataa ccttagctat cgtgaagttc aagaaatctt atatgatcgt ggcattaacg
     2701 tttctcatac gacgatttat cgttgggtgc aagaatatgg caaactactc tatcaaattt
     2761 ggaaaaagaa aaataaaaaa tccttttatt catggaaaat ggatgaaacg tacatcaaaa
     2821 ttaaaggaaa atggcattat ttgtatcgag ccatcgatgc agatggttta accttggata
     2881 tttggttacg taaaaaacgg gacacacaag cagcctatgc ttttcttaag cggttagtga
     2941 agcagtttga tgaaccgaag gttgtagtca cagataaagc cccctctatt acaagtgcct
     3001 ttaagaaact aaaagaatac ggcttttatc aagggacaga acatcgtacc attaaatacc
     3061 tgaataattt gattgaacaa gaccatcgtc cagtaaagag acgcaataaa ttctatcgaa
     3121 gtttacgcac tgcctcaccc acgattaaag gcatggaagc catccgagga ttatataaga
     3181 aaacccgaaa agaaggcact ctcttcgggt tttcggtctg tactgaaatc aaggtattat
     3241 tgggaatccc agcttaaatt atagataccg taagggattt tattctttat ttaaaacttt
     3301 gcaacagaac cgtaacaaga tatatcttaa aacaaaaaac actaggtcta tttttcctag
     3361 cacttacacc agttatagat ttaatattac ttataacaac aggtatagac ctcatgaatg
     3421 gagcaacagc tgcaacccct catgctatag ctgcggtcta tatttcagta tctcttgtct
     3481 ttgggaaaag catgataaat tgggcagatg atagatttgg atattatgtg atgaaacaag
     3541 gacccaaacc ttacaaacct gtaggattag cttactctaa aaactatgct aaaagttggt
     3601 tgaaacattt actttcttac attataggaa caggtatttt gcatttgatt atttttttaa
     3661 ttaatgataa aagtcgtaca gaagctatgg ataatgttat tcatgtttgg acaattgtca
     3721 ttattattga cttaatcatt tgtatttcat attttgtgtg gccaccaaaa aatacggaaa
     3781 gtaaattatg attacaattt taaaaaaaga aaatactgac gttttgaact gacctcaatt
     3841 agtgggagtt ggtgctagta tgaaaattag gacgcctttt cgtagagtct tgaatcaaat
     3901 ataatgagac taaggaaggt gtctaaaatg acaaagtaca gtgaatcttt taaagaaatg
     3961 attgttgatt tagctaataa tgggacaaaa gcgaaggatt taagtagcga gtatggcatt
     4021 tcagaagcag ccatttataa atggaaaaaa ttatacacga aagactctaa aaccggtgtt
     4081 aatgaaaaac aaatgcaaac ccttagaaaa gaaataaaac aacttaaact cgaaaatgaa
     4141 atactaagaa aggcagccgc catattcgct caagatccac tttaactaaa gtccgttgga
     4201 ttaaacgcta ttcaaaaatc tttaatgcca gccatctatg ccgcatatta aatgttccaa
     4261 gaagcttata ttattactgt attaaagaga aatattctgt tagaaatgag agactccttc
     4321 gttttaaagt tttaatcaaa gccttatacc atcaatataa tggcatctat ggtgcgccta
     4381 aaatccacgc ttttttgaca caaaaaggct ataatgtttc tgttaagtat gttcaaaaaa
     4441 tcatgcggtt acttggcatt acttctgtta ccattaaaaa attcaaacac tatactaatt
     4501 ccaaagttaa aggtgtcttt aaaaatatgc tgaaaagtat gatgctatct atcttaaaga
     4561 atgcaaccat cctaatgaaa tttggcaagc agatcatact atgttagata tagaggtttt
     4621 aaacgaaaaa aacaaacttg aaagaccttg gctaactgtt gtcttagatg atttcagaac
     4681 aagaaagaaa tgagagtaaa cgtcggcaaa cgcaagggat taaagtagcg aaagaaaaag
     4741 gagtatacaa aggacgacct gtactttatt caccaaatgc aaaagattct caaaaacgtt
     4801 tagtttatta ctgagttata gaaatgttag acaaatgttt ttcaattagc aatatagtta
     4861 cggaagtaga tgttactaga caaactatat agagtattaa aaataatcaa ataaactcat
     4921 aattttaaaa tttactactc tattttgctc aaaatagaga taaaactgac aaatttactc
     4981 ttttgtgtta ttttggtata gattaatata agaggaggat aaaaatgatg gaaatggtgt
     5041 ttacccttta taaaacaatt aaagtttcag actatctcaa agttgaggga caagtatgta
     5101 cttttttaaa cagaatacca aaatccagac tttttactat aatccttacg taaaaaagta
     5161 aaatattgat ttatgtaaca aaagtctgat cttaagatta ggttttttat ttggataatt
     5221 gagaggtgaa attgatggtt aaagcagtcg atttagcctt ctaaaatgag catttaaatt
     5281 ttaggaggct gtaaaatgaa tcatcaaaat gaaaaaaata tagcatcaaa tgtgttgtta
     5341 attagtatct taggcttgtc tgttttagtg ggttcagtta ctgcagatat ggttaatcct
     5401 gttctcggtg tgattggaaa agaattaggt gggtctgagg cgcaagttag ttgggtcgta
     5461 agtggtgttg ccttagttct atctatagca attccctttt atggacgttt atctgatttt
     5521 ttaaatatta aaaaactctt tactaacgga tttctaatat taactatagg aagtttaata
     5581 tgtatattcg cgcccaattt aattatttta gtattgggta gaatgtttca aggagctggc
     5641 atggcagcca tacctgtgct atctattgtt ataatatcta aaatttatcc gcctggacag
     5701 agaggaagaa ttttaggtat tattgctggt tgtattggcg ttggcactgc aggaggccca
     5761 atatttggcg gcgttgtagg acaattatta ggttggcaat cattattttg ggtcactttt
     5821 gttctgggtt taattatagt tctaggtgtt caaatatcaa tgcctaaaat agaatcacca
     5881 gataataaca gtcatcaaaa ttttgatgtt ttaggtggac tattattagg attaaccgta
     5941 ggtggttttt tacttggtat tacgctttca gaaatgtatg gtttgatttc tatacaaaca
     6001 accacaagtt tttctatatc tatgatagct ttaatagtgt taatatatcg cgtgattaat
     6061 gttaaaaatc cttttatccc tccagttata ttgaagaacc gtttatatgt aagctcaatt
     6121 ttcattgtat ttctttcaat gtttgcttat gtctctatgc ttgtttttat tccattatta
     6181 gttgttgagg ttaatgggtt aagtactgga caggcaggct taatattact ttctggtggt
     6241 gtcgctgttg caatcctttc accaatagtg ggaagattat ctgacaaagt gcatcctaaa
     6301 atactattat tagttggact aattattatg ggcttatctt ctttatatat gagcttcgta
     6361 gcaggcgcat cacctgtatt attatctatc gggagtttag ggataggtat cgcttttgca
     6421 tttattaact ctccagtgaa taatgttgca gtacttgctt tacctaaaga acaagttggt
     6481 gtaggtacgg ggttgtttca aggtgcaatg tatcttgggg caggaacagg tgcctcacta
     6541 ataggggctt tattgtcaat gagacatggg gttaaagcat cttttaatcc tttttatact
     6601 ttaactgccc cgcactattc tgatatattt ttaaccatta cgtgcatcgt gttagttgct
     6661 ttaattgtta ctttaaatat aagtagtagg gatttaaagc aataaaacct ttttattaca
     6721 cagatataca tctgttttta aatattattc agaaactaaa ttgttaatag caagaacaac
     6781 taaataattt taaaaaacag ggcttattaa caagccctgt tttgcatttt agccaagaaa
     6841 ataaccagtt tctgtacact atctaactat cacttttttc aattcataat attgtatagc
     6901 attccatacg tttcattttc tcatttatta agtaaaatca ttctaattta gcaagtaaag
     6961 tcacaacggt cttagaatgc gcctctcaaa cgtcaaaata caaaaaagcg cctataaata
     7021 ggcgcttttt atgattatcg ttgcaaagct tgctgttctt tttttactct tggttgcttc
     7081 aaatctgggt tagcttttgc aaagtctttt aattgttgct gggtcttttg actaatttcg
     7141 attttaactt tgtttagttg ttcctgtatt tgttgtttat ttgcacctgg ctcttttaac
     7201 ttatcatgca atgctttgta ttgatctgat aaggctggtt gtttttgtgt ggctttatta
     7261 tcaagaatct tagtgttttc ctgatatgga ttgttcaaat caggttctac aagttcacta
     7321 ccgtataagt tgttttgata ataactaaac acattatatg atttttcggt tctgttgcaa
     7381 agttttaaat ctactatcaa ataaggtaga ataatagaaa aagatagcag gaggaatgac
     7441 gatgaatcat tttaaaggaa agcaatttca gcaggatgtg attattgtag ccgtgggcta
     7501 ctatcttcgt tataacctta gctatcgtga agttcaagaa atcttatatg atcgtggcat
     7561 taacgtttct catacgacga tttatcgttg ggtgcaagaa tatggcaaac tactctatca
     7621 aatttggaaa aagaaaaata aaaaatcctt ttattcatgg aaaatggatg aaacgtacat
     7681 caaaattaaa ggaaaatggc attatttgta tcgagccatc gatgcagatg gtttaacctt
     7741 ggatatttgg ttacgtaaaa aacgggacac acaagcagcc tatgcttttc ttaagcggtt
     7801 agtgaagcag tttgatgaac cgaaggttgt agtcacagat aaagccccct ctattacaag
     7861 tgcctttaag aaactaaaag aatacggctt ttatcaaggg acagaacatc gtaccattaa
     7921 atacctgaat aatttgattg aacaagacca tcgtccagta aagagacgca ataaattcta
     7981 tcgaagttta cgcactgcct cacccacgat taaaggcatg gaagccatcc gaggattata
     8041 taagaaaacc cgaaaagaag gcactctctt cgggttttcg gtctgtactg aaatcaaggt
     8101 attattggga atcccagctt aaatcataga taccgtaagg gattttattc tttatttaaa
     8161 actttgcaac agaaccacat gacaaatgca agctttggaa tttacattat tcattatcct
     8221 gttgttgtgt gggtatgcta cttgctttac agttacctca acttaccgat gatatttatc
     8281 tatattcttg ctttagggct tgaactgata ctgacaccgt taatttatga gctgtttaaa
     8341 aggattcctg tagttcgctt tttagtattg gggataaaaa aatgagcatt tcttactatc
     8401 ctattaaacg agtatagcta tcctatcggc agtagcgttg tctatggtta tggcttgcct
     8461 gcatattaaa aaagggcaaa agaaaaacag aggattttac ccctctgttt cctcttttgc
     8521 gttacatatt cagtttacag ttgtacaata cttggtctat aaacaaactg taaagtgagc
     8581 agcttagatg agctattgac atatgcactc aagctctcta taattaaaat ataaaataag
     8641 agagggtgag cacagtgtta ttcgggaagt tttgcattga ttttggctct acacaacaat
     8701 ataagacaga gcattgtgtg gagcccaatc agataaaatg tttatttgag aggcagggct
     8761 atttaaatca gaaatttgtg atttaagagc cttatttgtg ttgcctttca ataagcaaac
     8821 tcaatgattg gatatgtggc cgtagacaat gttttgtcta cggccttttg ctgtctatat
     8881 ttcatctatg ttattggcat agtgtctgaa aaagcagagg gctacgtcta tgggacgtat
     8941 tgctacctct gcttttattt tttaaatgat gatatcagag aagaaaatat atccccgcac
     9001 aggagataat caagcaagga aaactgtaag ccataaaatg atggcttgca gtatgtatga
     9061 cgatggagga atgatacaag atgaaaggta aaaatatgaa tttagccttt gggttggaag
     9121 aaatttatga ggatgctgag tttcaaatcg gagatttgga taaggtcggt attgtcggcg
     9181 tgaacggagc cggaaagacc accttgttcc gcctgctgtt gggagaactt gaacttgata
     9241 atggttcact gaccagtgga aatgcccgta ttggttatct cccacaggaa attgtcttgg
     9301 aagatgagga tattaccgtt tgggatttcc tttttgaggg acgtccgatt aaaaagtatg
     9361 agcaggaatt ggaagaaatc tataaaaagc ttgaaaccgc agtcaatgca gagcaggaag
     9421 cactgcttgc ccgaatggga acattgcaag aacgcttgga gtatttcgac ttctatgagg
     9481 cagaaacaat tctgttggag tttgcagata aaatgagcat tgatgcagaa ttatatcatc
     9541 gtccgatgag agagctttca ggcggacaaa aatccaaaat ggcatttgcc agactactat
     9601 attcaaaacc ggaaattcta ttgttggatg agcctaccaa ccatttagat gtcagcacaa
     9661 aggattttgt tataaaatac ttaaagaatt ataggggttc ggtactgatt atcagccatg
     9721 atattgattt tctaaatcgg attatcaaca aaattatgta catcaacaaa gctacccata
     9781 aaatatctgt ttatgatgga gactactaca tctacaagaa aaagtatgca gaggaacagc
     9841 ggattcgtga aatggcgatt gtacagcagg aaaaagaaat aaaggagctt tccgattttg
     9901 tacaaaaagc aaaacaagcc agtcagacca atcatcacct caaacgaatg ggtcaagagc
     9961 gagccttgcg gcttgataaa aagcgtggag agctgcaaaa gagaaatcga ctgtacaagc
    10021 gtgtgaagat ggatattcgc cccaagcgtg aaggggcaca agttccctta gaggtggaaa
    10081 atatcacctt ccactattcg gggtatccca ccctttatca gaacctttcc tttcagatta
    10141 acggaagaga acgatttctt gtggtgggtg aaaacggtgt cggtaaatcc accttattga
    10201 aattgatgat gggtattctc agtccagatg aaggatgcat tcgctttaac cagaaaactg
    10261 atattgcata ttatgcacag gaactcgaac agcttgatga aaacaaaacg gtcattgaca
    10321 atgtggagtc tgaaggatat acaccgtggc aaatcagagc cgtactgagc aacttcctgt
    10381 tttatgatga cgatgtaaac aagaaagtat ctgtgctgtc ccctggagaa aaagcaaggg
    10441 ttgccctttg caaaatccta ttacagaaag ccaatctttt gatactggac gagccgacca
    10501 accaccttga cccagaaacg cagaaaatca ttggcggcaa cttcaatttg tttgagggaa
    10561 ccattattgc cgttagccat aacccatcct ttgtggaaca aatcggaatt agccgtatgc
    10621 ttattttgcc cagcggtcga attgaaccct attcccgtga gctgcttgag tattattatg
    10681 aaatcaacgg ttctgttgca aagttttaaa tctactatca aataaggtag aataatagaa
    10741 aaagatagca ggaggaatga cgatgaatca ttttaaagga aagcaatttc agcaggatgt
    10801 gattattgta gccgtgggct actatcttcg ttataacctt agctatcgtg aagttcaaga
    10861 aatcttatat gatcgtggca ttaacgtttc tcatacgacg atttatcgtt gggtgcaaga
    10921 atatggcaaa ctactctatc aaatttggaa aaagaaaaat aaaaaatcct tttattcatg
    10981 gaaaatggat gaaacgtaca tcaaaattaa aggaaaatgg cattatttgt atcgagccat
    11041 cgatgcagat ggtttaacct tggatatttg gttacgtaaa aaacgggaca cacaagcagc
    11101 ctatgctttt cttaagcggt tagtgaagca gtttgatgaa ccgaaggttg tagtcacaga
    11161 taaagccccc tctattacaa gtgcctttaa gaaactaaaa gaatacggct tttatcaagg
    11221 gacagaacat cgtaccatta aatacctgaa taatttgatt gaacaagacc atcgtccagt
    11281 aaagagacgc aataaattct atcgaagttt acgcactgcc tctaccacga ttaaaggcat
    11341 ggaagccatt cgaggattat ataagaaaac ccgaaaagaa ggcactctct tcgggttttc
    11401 ggtctgtact gaaatcaagg tattattggg aatcccagct taaatcatag ataccgtaag
    11461 ggattttatt ctttacgccg attgtaaaat taagctagac aaataaataa gccattcgtg
    11521 ctacactcaa aatgtaattc cgactaaaga aaacatagga gtgatcacga atgacctaca
    11581 cccatcttac cacggatgaa ctggtgatga tagagtctta ctaccaccaa aacatcaaaa
    11641 ttgtgaaaat tgctgagtac ctgaaacgat ctcgaacacc gatttataac gtcattaatt
    11701 tcttgaaaga aggccatacg gccctcgaat actaccaaca gtataaagaa aataagaaac
    11761 ggtgtggcag acgaaacatc gtcttgccaa agaaacaaca gtcctacatt aaagaaaaaa
    11821 ttgcccaagg ctggacgcca gacgttatca ttgggcgtaa agagaaacca atcagctgtt
    11881 ccgtaagaac cctttatcgc cagttcaagg aaaaggtgtt cgatgaatcg actttgccca
    11941 tgaagggtaa gcggaaacca aatggacatc aagaacgccg aggaaaacag gcttttaaac
    12001 ggaatatcgt tgaaagagaa actgattacc cgacatttaa agaagagttc ggccatatcg
    12061 aaggcgatac cattgtaggc attcatcata agagtgctgt cataactttg gtagaacgtc
    12121 tatcgaaaat catcatcacc ttgaagcccg aggggcgcaa ggcgatcgat attgagaata
    12181 ctctgaacca ctggtttgga tcgattccca gacatttatt taaatccatt acctttgatt
    12241 gtgggaaaga attctctaat tggaaggctt taagtaacca acatgacatc gctatttatt
    12301 tcgctgatcc agggactcct tcgcaacgag cactgaatga aaattccaat ggcttgctgc
    12361 gaaaagatgg tctgccaaaa aacatggatt ttaatcaagt cgaccaagct tttatctctt
    12421 cagtggcgaa taagagaaac aatattccac gaaagtcctt ggattatcaa acacccctgg
    12481 aagtatttat gagttacatg aatgaagata ttttgtctag cttaatttga caaatcaaat
    12541 tatttaaaac tttgcaacag aaccttagca gcagtgctga tttttatgat agttatttgg
    12601 ttcttaaatg aaagatctaa agacaatcaa caccgtaggg atatggagat aaaatcaata
    12661 gagtcaatag attatttatc gataataaca ctaaaaaagc cacgttccta aacgtgactt
    12721 acgctgaacg atatgtgttg tttggtagac gaacaaatcg ttcattataa atatatgatg
    12781 gtatcctaat atagtaagcg tggctagcat acctttaatt actttacctt ttacagttac
    12841 catacacatt ttttgagcag aaatcaagta aataaaaaaa tattatattt cacaacatgc
    12901 taatagactc atatctagaa cgcattaagt atttacctgt ctggttcgct gagacttctt
    12961 ttttaacttt cttcaatttt cttctttatt ctaaaaagcg tactgcgact gaaaccggtt
    13021 atagcttcaa cttccttata cgatttacct gaagtaagca gttcatatgc gtgcctcttc
    13081 ttcggtgtga ttgttgcttt cggacgtcct tctctgaaat taggattatt ctttcttgca
    13141 aacatttttc cttcttgggt acgttccaca atcatatcac gttccatttc tgctacactc
    13201 aacaacgtcc gtgtcaccat tcgccccatg gacgtatttt caatcgttcc tagattcaaa
    13261 accttgatcg ttacgttatc atcgagtaaa ggttcaatga tctctaatgc ttctctcgtg
    13321 ttacgagcaa atcgatcaag cttcgtaaca actatttcat ctccaggctt cagaccagcc
    13381 aacagctgat tgaattttgg ccgatcccgt tttgtacccg taaatttttc tgaaaaaata
    13441 ttcttcttct ctacgccgtt ctcaagcaac tgttgaattt gttcttttgt actttgagaa
    13501 gcggttgaga cacgtgcata tccatatttc gtcatttggt ccacctactt ttacaaatca
    13561 tctatcgtat actcagaata cccttcatag aaatagctga catcgattcc tttcatatat
    13621 aactcgcgat cgtcaatttt atcagtcaga gcattggaaa ttagatagcg tatttccaaa
    13681 tcgtttatgg gacttcgctc cattgcagaa agatagtctg ctttatcgat taagttccaa
    13741 tctacaactt tttgcaattc ttcctttaaa atgagatcca gccaaattct agtacttcgg
    13801 ccatttcctt ctcgaaatgg gtgagcgata ttcatctcca catatttctt gataatctct
    13861 tcaaaagaag tttgtggcat ctgatcaata tgctgtaacg aatgttctaa atacataact
    13921 ggtgcaaatc gaaaatttcc ttttgcaata ttgaccgatc ggatttttcc ggcaaaatcg
    13981 taaatatccg aaaatagaaa ttcatgaatt tcagataaac ctttaaatgt accaacttcg
    14041 atttcattta tttttccaca atcgtacaat tctttcgctt tttgtttact gagtttttct
    14101 tcaaccttag ccaactcaac ttgattggtt aatcccaatt tattctctaa aatcatgcga
    14161 aatctcctta actttatgac ataagtttat gaaacactct caaccccatt atatcgcgat
    14221 tttgtttatg tgtcaaaaac tattaagttt ctgacccccg atagattttt caagtgtctc
    14281 tattttgcac agtctagttg gttctgttgc aaagttttaa ataaagaata aaatccctta
    14341 cggtatctat gatttaagct gggattccca ataatacctt gatttcagta cagaccgaaa
    14401 acccgaagag agtgccttct tttcgggttt tcttatataa tcctcgaatg gcttccatgc
    14461 ctttaatcgt ggtagaggca gtgcgtaaac ttcgatagaa tttattgcgt ctctttactg
    14521 gacgatggtc ttgttcaatc aaattattca ggtatttaat ggtacgatgt tctgtccctt
    14581 gataaaagcc gtattctttt agtttcttaa aggcacttgt aatagagggg gctttatctg
    14641 tgactacaac cttcggttca tcaaactgct tcactaaccg cttaagaaaa gcataggctg
    14701 cttgtgtgtc ccgtttttta cgtaaccaaa tatccaaggt taaaccatct gcatcgatgg
    14761 ctcgatacaa ataatgccat tttcctttaa ttttgatgta cgtttcatcc attttccatg
    14821 aataaaagga ttttttattt ttctttttcc aaatttgata gagtagtttg ccatattctt
    14881 gcacccaacg ataaatcgtc gtatgagaaa cgttaatgcc acgatcatat aagatttctt
    14941 gaacttcacg atagctaagg ttataacgaa gatagtagcc cacggctaca ataatcacat
    15001 cctgctgaaa ttgctttcct ttaaaatgat tcatcgtcat tcctcctgct atctttttct
    15061 attattctac cttatttgat agtagattta aaactttgca acagaaccgt gtgaagtatt
    15121 tcagtgaatt attagccagt agcgaaaggc tcagtgtaga tttagaatcg gttatccagt
    15181 cctacaatta tggtggtggt ttcttagggt atgtggctaa tcgtggaaat aaatatacct
    15241 ttgaactggc tcaaagtttc tcaaaagagt attcaggtgg cgaaaaagtg tcttacccca
    15301 atcccatagc catacctatc aatgggggct ggcgatacaa ctatggcaat atgttttatg
    15361 tgcaactggt aacgcagtat cttgtcacaa cagagtttga tgatgatacg gtacaagcca
    15421 tcatggacga agcactgaaa tatgagggct ggcgatacgt ttacggtgga gcttccccga
    15481 ctacttcttt tgattgtagc ggactgacac aatggacgta tggaaaagct ggaattaact
    15541 taccacgaac cgcacaacag caatatgatg tgacccagca tatcccacta tcggaagcac
    15601 aagctggcga tttggttttc tttcattcta cctataacgc tggctcttat attactcatg
    15661 ttgggatata ccttggcaat aaccgtatgt ttcatgcagg cgacccaatc ggttatgccg
    15721 acttaacaag cccctactgg caacagcatt tagtgggagc aggacgaatc aaacaatgag
    15781 aaaggaagat ttaatgatga aatttagaaa aaatcagaat aaagaaaaac agataccaaa
    15841 ggaaaagaaa cctcgtgtct ataaggtcaa tcctcataaa aaggttgtga ttgccttgtg
    15901 ggtactttta gggcttagtt tcagctttgc gatattcaag cactttacag ctatagatac
    15961 tcatactatt cacgaaacaa ctatcataga aaaggaatac gttgatactc atcatgtaga
    16021 aaattttgta gagaactttg cgaaagtcta ctattcatgg gagcaatccg ataagtccat
    16081 tgataatcga atggaaagtc taaaaggcta tctgacagat gaacttcaag ctctcaatgt
    16141 tgatacagta cgcaaagata ttcctgtatc gtcttctgta agaggatttc agatatggac
    16201 ggtagagcca actggcgaca atgagtttaa tgggttctgt tgcaaagttt taaatctact
    16261 atcaaataag gtagaataat agaaaaagat agcaggagga atgacgatga atcattttaa
    16321 aggaaagcaa tttcagcagg atgtgattat tgtagccgtg ggctactatc ttcgttataa
    16381 ccttagctat cgtgaagttc aagaaatctt atatgatcgt ggcattaacg tttctcatac
    16441 gacgatttat cgttgggtgc aagaatatgg caaactactc tatcaaattt ggaaaaagaa
    16501 aaataaaaaa tccttttatt catggaaaat ggatgaaacg tacatcaaaa ttaaaggaaa
    16561 atggcattat ttgtatcgag ccatcgatgc agatggttta accttggata tttggttacg
    16621 taaaaaacgg gacacacaag cagcctatgc ttttcttaag cggttagtga agcagtttga
    16681 tgaaccgaag gttgtagtca cagataaagc cccctctatt acaagtgcct ttaagaaact
    16741 aaaagaatac ggcttttatc aagggacaga acatcgtacc attaaatacc tgaataattt
    16801 gattgaacaa gaccatcgtc cagtaaagag acgcaataaa ttctatcgaa gtttacgcac
    16861 tgcctcaccc acgattaaag gcatggaagc catccgagga ttatataaga aaacccgaaa
    16921 agaaggcact ctcttcgggt tttcggtctg tactgaaatc aaggtattat tgggaatccc
    16981 agcttaaatt atagataccg taagggattt tattctttat ttaaaacttt gcaacagaac
    17041 cctctaagta tctatcattt atctagtata aaaaattatc taaaaaattc acgaccactt
    17101 aagttaaatc tttgtatatt aaatatctgt ctattcttaa gcatgatcct tctgttaata
    17161 gcttctacaa aagtaataaa tacccataat gaagccgaaa ataattctct taaatattgg
    17221 gaaagaacta ctaatttata caaaacaaat attactaatc aattaaatag aaacaacacc
    17281 gtagaagaaa ataactactt gaaaaaagct agtaaatttg tttataaaat acagaagaat
    17341 tataaaactt ttattatcgc gccatacaat tacgcaacta tccaagagaa taataaagaa
    17401 ttttttattg gacaaaaagt ttatccaaat tttgaagact acgttagtca acctgctggt
    17461 gcaggaatat gtgttgattt aaactatcta aaatattaca atcctatttc ttttgaagaa
    17521 tctactgact taaatttaat aaactctgat ccactaacta cttacattct agtacctaaa
    17581 aaatataaag aatatgcaaa aatgattgaa aaaaattatt tagaagacat acagtttaga
    17641 cttgaggact ctcctcctca agctccttat aaaaatccta atttgaaaaa tttaaaaata
    17701 aaactaatat ttgttaataa taaccaaaag tattttagtt ttaatacctt atatggaaag
    17761 gcaaaagata actatacaat aactgatccc atagttagag ttattaatcc agaaataaca
    17821 gaatcattat tttggggaaa tatattgact agtgatggtg gattattttt tgatcagaaa
    17881 catacttcaa accaaaactt ttttaatcaa attaatccgt atataaaaga atttaaccta
    17941 gaaaatatca taaatttttc ttattctgtt tttcaagaaa ctggtgaatt attatctcaa
    18001 aaaaaagtaa ataaattaaa tgcatatcta caatatcttt taatattagg attatttata
    18061 ataattaatt ttcaaatgat ttttgttagt tttactataa attcaaaaaa aatagcttta
    18121 aaaaaaatat ttggatattc accaataagt caagttttag atttatgttt actccctttt
    18181 acaatagagt tatttgctac tatgtgtttt caattgatat tttcaaaaaa cacttacttg
    18241 tattttataa tttttatgat ctttttaata aatctaatta cttctattat tatttataaa
    18301 aaaaatagtt ttaaatattt taaggagaat attttatgat attatcagtt gagaatttca
    18361 ccctgtcaat taataaaaaa aagatcaaac aaaattggaa cttttcaata tcagaaaaag
    18421 attttattat agtaacagga aaaagtggta gtggaaaaac tactctgtta aataatttaa
    18481 gcctaataga taaacaatat accggtaact tattctattt tgaaaagaaa gtttctaaac
    18541 atgatataca acgtctacga agaaatcata ttagctattt atttcaaaac tatgctcttc
    18601 ttgaaaatca aacagtacaa tacaatttcg aattagcaaa aaagtttaac agtaatattt
    18661 ccaatgatca tatttataat ttattaacag atttttcttt gccaaaagat atcttaaaag
    18721 aaaaaatctt tctcttaagc ggtggagaac aacaaagaat agcattaatt agaaatatgt
    18781 taaaaccatt tgatatatta tttgcagatg aacctacagg aaatttagat aaagaaaact
    18841 caacttttat aatgaacttt ctgaaaaatt taacagaaaa agaaaaaaaa gccgttgtac
    18901 tagtaacaca tgacttaaat gttctaaact atggaactaa tattatagaa ttataatttt
    18961 tacccgtgat gctagctgat ttaaaactag caccacgggt atttatttta tattccatct
    19021 ctcctatccc aaaatttaaa taatcactta ataaaaagga ggcacccaag tgattttatt
    19081 gaaaaaagag tatgaaaaat tttatgatag acttatttat tctttgcaat tgccaaaaaa
    19141 attaaaccgt caattacaaa agacttatga aactaaatca actgaagaat gggagagtta
    19201 ttgctagatt tttggtagaa gtaacaaaaa gtggacatat tatcataatg actcgccgaa
    19261 agtctgataa aaaattggct aaaaatattg ctgaatgttt aataaaacta tcagttttag
    19321 ctaaatagtt agtagtttac acaaaaaagc atttatgttt tttgttgcaa agtaacaatt
    19381 tcatcttcgg tgaaataagc gaaactttac aaaaagtggc tagcatttgc tagctttttt
    19441 tgtattgtgg agcgtggctt ttgaggggga ttcaaggggg agcttgcgcc cctttgacaa
    19501 gcggttattt gcactaaata cgtaggtatt tggctagcaa atatagagct tgccaaaccc
    19561 ttttagtgag ctttactcat tgtacctttt taggtacaat ggtattgcga acgatacgtc
    19621 cgtaggacgt actgaaaggg tgggacttat gagcgaacaa aatcaaaatt tggctagcaa
    19681 ttcttctaaa aaatatacct atcgatccga gccaaaacaa atcagttttc gagtgagcga
    19741 atccgaattt gcaaagctga agcaatcggc tgaagctttg caaatgagtg tgccggcttt
    19801 cgtgaaagcc aaggcacaaa acgcgcgtct ggtgacaccg aaagtggcgc cagacattgc
    19861 ccaggcaatc gcgcgcgatt tagccaaagc tggagggaat atcaatcaaa ttgctaagtg
    19921 gtgcaataca caccaacatg acgttgcttc tggtgacgct caacgtttat ccgaaaacct
    19981 aaaaatcatg caaaaggagc tacaaaagat atggcaacaa ttaaggtaag ccgaaccact
    20041 tcttgtagtc gtgcaattaa ttacgcagaa ccacgagcaa ccattaaaac aggaataaac
    20101 tgtgacgtcg attatgccaa aagtgaaatg aaacaaattc gcatgctgta tggaaaagac
    20161 gaccgtgtac aggcacactt attgattcaa tcttttcgac caggagaaat taccgctgaa
    20221 aaagctaatc aactaggggc agagtatgca aaaaaaatag cccccgatca ccaaacagct
    20281 atttacacac atacagacaa agaccatatt cataatcaca ttgtcattaa ctccgttaat
    20341 ctggagactg gaaaaaaatt tcaagctcat ggtcaagcat ttctaaacaa atgttatgac
    20401 ctaaatgacg agatttgtct tgcacataac ttaccaatca ctgagcgagg aaagaaacca
    20461 gaaaaacgaa ccatgtctga aataaaatta aaagaaaaaa atgaacctgt ttggaaagac
    20521 gaaattcgga ttgcgatcga tcaaacaatg aaaaacaaaa aaaccagaac ctatgaccaa
    20581 ttttgtaatt ccctcaaaac attggggatt cattgcttca atcgcgggaa aaatttcact
    20641 tacgaattga tccacaaaaa gaaaaaagta cgatccaaca gactaggaaa ggactacgaa
    20701 aaggagacga ttttacatga gctggacaga cgagaacgaa cctataacca acagcgaacc
    20761 aacgagctac gaagagctcg agctagcatt cgcgaaactg cagaagaagt acgaagagaa
    20821 caacgaactc ttacgcctga acaaccggaa attagaccgg ctcgaagaaa ccatgaacaa
    20881 cacgttgaaa gaggaacaga ccaccaacaa gaattatcgc tctaaaacgt taaaagacat
    20941 agaaaacgaa ataaagaaac aacgtgcttt tctcgttcct tatacgcaag aaaggataca
    21001 aactacgatt gatttacaag ttaaaaaact ccatcaagag ctattagacc agcgaaataa
    21061 ggaacagaaa aaggtgctta ttcaacgatc attggatttt cttgccccct tatgttgctt
    21121 agtcctgaca ctgttcgcat tttggttagt atggggaggc taaaatggca ttttatttac
    21181 cctatctact catttttgtt agtatttcag gaagtatttg gctcatctat aaaatttttc
    21241 aaacaagata ttcattaaaa ggctctaaaa ttcgatttaa gcgatttttc tttcttggct
    21301 gtatattttc cttgataatc gtttcaagcg gcttattcgg cgttttagag ggaaataagc
    21361 gcgtttctag aagtatttta ttaggaaatg tcactcaaaa gtatgaatca gcgcgtgata
    21421 aaaagaaaaa agagcaagca ttagcacaaa aaatggaaga gtttaccact tgttatgagg
    21481 aaatgaacga tatttttgtg aatcaagaaa aacgtttgac ggataaaaac atggaaaaac
    21541 tcactcgtct ttatcaaaac ttgccagaaa aacagcaaaa agaggttcaa gacaactatg
    21601 agcgaaccaa aaaagacgtg caatatgtaa aagatacaaa gatagaagaa gcctgtagtg
    21661 atctatttgg agacacaaac ccttggtttg ccagtgaaga agaaaaaaaa gaaaaacaac
    21721 aatctgtcac atatgaacgc tatgaaatct tacttcaaca agcaactaac atgcaaaatc
    21781 cgacaaaaaa agaaaccgcc ttaaactatc taaaaagtgt caaggaatgg ttagatcagc
    21841 aacaacaaaa ttgaatttga tttaaaatca tgttaaactg aatgtgcaaa tgatcaaaca
    21901 ttagatacac gaaagcccca gagaggtcgg attctctggg gctttttttc aggttgatgt
    21961 cgcctttatt gattttactt cttgtttcgg ttattcaacc aataactgaa taaagagaca
    22021 caaactccta caagaagggg gcaaatgaac agttcaaaca ttagatacac ctccttccag
    22081 tcgcaagact gtcggatagg cgacaagtta ttatatctta aaaaattaaa tttgtgtggt
    22141 gtttttaagt atcacttgtt ttagggttgt tagggcttgc cctgaccgcc tgtaaggcgc
    22201 ttctcgacta gattaaggga aattaatcaa gaattgtctt agaacggctt agacaagctt
    22261 tcagagtctc acacctcctc tttgaacaac ggttttagca aaggagccgg aggcgactgc
    22321 gcagtataat atgagagcat agcgatcaca cctttttagc gaccgtaggg agcaagtttt
    22381 ccagtttaga aaaattcgcg aacctttttg gaggaaaaag taggagtttt ttaggcggga
    22441 aattcaatgt gctcttaaga tatactgtta gatatactgt tagatatact gttaataata
    22501 actgttaggg attagcaacc ttatgggaga gtaagtattg acataggtag tgggggataa
    22561 attgtcacac tatgggggat aaattgtcac actatggggg ataaattgtc acactatggg
    22621 ggataaattg tcacactatg ggggataaat tgtgttttac atcctcttat gtctatgata
    22681 acataattta ttgaggtgat ttttattgag taacgatata gttcgatata ataatggatt
    22741 aaattctgtc cctttaagaa aatttacccc tatagatatg gatttatttt ggggaatatg
    22801 ttctaaaatg aaaagaaaag gtacaaaaga agaaattttt acatttaaac aaataaaaga
    22861 attaattgat tacaatataa atgcacgtgg cgaccgtttt gctaatgatt taataaaaat
    22921 gtcaaaaaaa atcattactt tgtcttttat ttatgaagac gaaaaaacat atgaacaatt
    22981 aaatctgttt caaaaattta aaatcgataa agtgaatgaa acattattaa taaaggtttc
    23041 tgaagaattt gaatatatac ttaattcaat cggaactaat tttactcgtt tcgaattaga
    23101 aaatatgaca aacttaaaga gtagctacgt taaagagtta tatcgccaac ttatggctca
    23161 taaagacaga agatctaaaa aaggtcactg gtttgtaaaa atagaagatt ttagagctct
    23221 attagcaata ccagaaagtt atcgcatgag agatattgat aaacaaattt ttgcccaagc
    23281 gaaaaaagaa tttttaaacg ttaattcaac tcaccctgct atttttaaaa cttttgaaat
    23341 caaaaaaatt aaagcctaca aaggaaataa gataggatct ctgcaaattt attttgaaga
    23401 aaatatacct tcaattacct tagataattg gttagagaaa taatacctaa caatttagga
    23461 ggcaattatc atgcaaccca aagaaacctt tacaataaag gaattatctg aattatttga
    23521 aataagtagg caagcaatct ctaaacatgt tgataaatta gacccgtcct tattagctaa
    23581 aaatgagcgt ggttataagg ttgtattacg ttctggagta ttgcaacttg ctagcaactt
    23641 aggtaaccaa aggttactat ataggttgca tgagtatgaa caagaaaacg ataaaaacgt
    23701 ttatatatca agcaaaaacg tgattgtaaa cgagttgcta gataagttgc gtgaagaaaa
    23761 tgaattttta cgagaacaac tttccctcaa agagcaaaat aattctaata tgcaaaaatt
    23821 actcgaccag caacaacagc tcaccctaca ggcaaatcaa cagatcgaaa aactgcaaga
    23881 acagttacaa ttagcttata cggaagaaac tccagaagat gaatcaacta ctattctttc
    23941 tgaagaaaca gaatcgatag aaaaacacac aaaaaagaag aagcaaaaat ggtggcaact
    24001 ttggaaataa ctggagggaa cattcatgac aagaaaaaat cttctattcg gttctatttt
    24061 actaggaatt ctaggcttca gtccgatgtt attgtcagta atcaataaag ggaataaaca
    24121 tggtgaattg aaattgaatc caaattatta caacagtcct aacgaagaat tgtttgtaaa
    24181 agagacggat aaataataaa aaagactgct cttccgagca gccagttaaa aaataatgag
    24241 tgtttattct tgaaaaagca cgcgcttatg aagcgctacc aaaaatttac catattttac
    24301 aaaaaataac aagtcttaaa aaaatgacag ataaaaatgc acaaagaatt aga
//
