LOCUS       NZ_CP062989             9294 bp    DNA     linear   CON 16-MAY-2024
DEFINITION  Klebsiella pneumoniae strain CriePir26 plasmid unnamed3 map
            unlocalized.
ACCESSION   NZ_CP062989
VERSION     NZ_CP062989.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN13153735
            Assembly: GCF_009661485.2
KEYWORDS    RefSeq.
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 9294)
  AUTHORS   Shelenkov,A., Mikhaylova,Y., Yanushevich,Y., Samoilov,A.,
            Petrova,L., Fomina,V., Gusarov,V., Zamyatin,M., Shagin,D. and
            Akimkin,V.
  TITLE     Molecular Typing, Characterization of Antimicrobial Resistance,
            Virulence Profiling and Analysis of Whole-Genome Sequence of
            Clinical Klebsiella pneumoniae Isolates
  JOURNAL   Antibiotics (Basel) 9 (5), 261 (2020)
   PUBMED   32429555
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9294)
  AUTHORS   Shelenkov,A., Mikhaylova,Y., Yanushevich,Y., Petrova,L., Fomina,V.,
            Zamyatin,M. and Shagin,D.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-SEP-2020) Department Of Molecular Diagnostics and
            Epidemiology, Central Research Institute of Epidemiology,
            Novogireevskaya str., 3a, Moscow 111123, Russia
REFERENCE   3  (bases 1 to 9294)
  AUTHORS   Shelenkov,A., Mikhaylova,Y., Yanushevich,Y., Samoilov,A.,
            Petrova,L., Fomina,V., Gusarov,V., Zamyatin,M. and Shagin,D.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-OCT-2019) Department Of Molecular Diagnostics and
            Epidemiology, Central Research Institute of Epidemiology,
            Novogireevskaya str., 3a, Moscow 111123, Russia
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. v0.4.8-beta
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 87x
            Sequencing Technology             :: Oxford Nanopore MinION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_009661485.2-RS_2024_05_16
            Annotation Date                   :: 05/16/2024 03:55:03
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,501
            CDSs (total)                      :: 5,376
            Genes (coding)                    :: 5,261
            CDSs (with protein)               :: 5,261
            Genes (RNA)                       :: 125
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 88
            ncRNAs                            :: 12
            Pseudo Genes (total)              :: 115
            CDSs (without protein)            :: 115
            Pseudo Genes (ambiguous residues) :: 0 of 115
            Pseudo Genes (frameshifted)       :: 52 of 115
            Pseudo Genes (incomplete)         :: 63 of 115
            Pseudo Genes (internal stop)      :: 21 of 115
            Pseudo Genes (multiple problems)  :: 18 of 115
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP062989.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     source          1..9294
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="CriePir26"
                     /isolation_source="traumatic discharge"
                     /host="Homo sapiens"
                     /db_xref="taxon:573"
                     /map="unlocalized"
                     /plasmid="unnamed3"
                     /geo_loc_name="Russia: Moscow"
                     /lat_lon="55.76 N 37.62 E"
                     /collection_date="2017"
                     /collected_by="Pir Nat Surg Centre"
     gene            <1..128
                     /locus_tag="GJJ26_RS27225"
                     /old_locus_tag="GJJ26_027225"
     CDS             <1..128
                     /locus_tag="GJJ26_RS27225"
                     /old_locus_tag="GJJ26_027225"
                     /inference="COORDINATES: protein motif:HMM:NF020569.4"
                     /GO_function="GO:0016788 - hydrolase activity, acting on
                     ester bonds [Evidence IEA]; GO:0043022 - ribosome binding
                     [Evidence IEA]; GO:0003723 - RNA binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=3
                     /transl_table=11
                     /product="colicin E3/pyocin S6 family cytotoxin"
                     /protein_id="WP_235302762.1"
                     /translation="SQHGELEGYRASDGEHLGAFDPKTGKQVKGPDPKRNIKKYL"
                     /name="colicin E3/pyocin S6 family cytotoxin"
     gene            138..395
                     /locus_tag="GJJ26_RS27230"
                     /old_locus_tag="GJJ26_027230"
     CDS             138..395
                     /locus_tag="GJJ26_RS27230"
                     /old_locus_tag="GJJ26_027230"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891189.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cloacin immunity family protein"
                     /protein_id="WP_004152553.1"
                     /translation="MGLKLHIHWFDKKTEEFKGGEYSKDFGDDGSVIESLGMPLKDNIN
                     NGWFDVEKSWVSILQPHFKNVIDISKFDYFVSFVYRDGNW"
                     /name="cloacin immunity family protein"
     gene            480..629
                     /locus_tag="GJJ26_RS27235"
                     /old_locus_tag="GJJ26_027235"
     CDS             480..629
                     /locus_tag="GJJ26_RS27235"
                     /old_locus_tag="GJJ26_027235"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891188.1"
                     /GO_component="GO:0019867 - outer membrane [Evidence IEA]"
                     /GO_process="GO:0019835 - cytolysis [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin release lysis protein"
                     /protein_id="WP_004152552.1"
                     /translation="MKKVKVVFLFILIFSGFLLVACQANYIRDVQGGTVAPSSSSELTG
                     IAVQ"
                     /name="colicin release lysis protein"
     gene            2110..4074
                     /locus_tag="GJJ26_RS27240"
                     /old_locus_tag="GJJ26_027240"
     CDS             2110..4074
                     /locus_tag="GJJ26_RS27240"
                     /old_locus_tag="GJJ26_027240"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004178196.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="TraM recognition domain-containing protein"
                     /protein_id="WP_004178196.1"
                     /translation="MFNTDSLAWKWHIPELARQIYPWVSWLYQEYYGLAGAFLVIGLFF
                     GLAELWAGRMRFVGLSHKERREYADRYKRDNKRPAPFSVLASLDSPGRMVRARRHVWNY
                     AYWLTGAAGLALLGGLVVAVFIESWGETVLRPDLYANADYYLLQPANLFGIAWCAGGLA
                     VGIVLARLLAFLLLDGHFAAADEAVNAKLNQESRRSSQRTGEMTDVRHLHFGEPVPVNA
                     LADFSSEQARQEQAVFLGKDEQGKPVLVPRDTWRKTNIQILGLPGSGKSVMATNALIRC
                     VRDFGDAVVYFDPKGDAWAPHVFRAHCPDFTLLDLRPGKPAQLNLFRDLDQYALKNLLI
                     AGLNLGETGDVADHYRISEQKAAKLIAEQFPQGANIQQVLAAAYALPEALKKDVKGLIT
                     RLENVADLSVLQTDSGIDVAGIINGGGCLYVIGSMDDEAVIRVQKMLFARCAQIIIARD
                     EFREWPHVSVMLDEIKYLLSKYVLNALGTLRSRDCNLLLAHQSLGDFGQCGQDLPAEFV
                     KTTVLDNTPIRWFYRAASLESAQWAAGQTGEIRVDVERRRASREAGNVEHISGDSFIQK
                     EARPLFDVNTLQHLPDGFAVMTGLGVARMAFSSPLRVERREIPLQRFPVLAKTDPLAEF
                     RPPADGGGPKADDDFAGIY"
                     /name="TraM recognition domain-containing protein"
     gene            4074..4805
                     /locus_tag="GJJ26_RS27245"
                     /old_locus_tag="GJJ26_027245"
     CDS             4074..4805
                     /locus_tag="GJJ26_RS27245"
                     /old_locus_tag="GJJ26_027245"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146447.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="MobC family replication-relaxation protein"
                     /protein_id="WP_004152551.1"
                     /translation="MALELYNVSHAKRQARNAEKTRLTLRWLREELCSTAELVARRLGI
                     AAVQPVYRFLDSLVAKGLLVRTKYPVDGRQVSVWGLTPHGVAFSFDEDEPLADVIPFQP
                     SRVSAAHLPHRLAVQSLRLDMEARGATGWRILHRLSLKGMKVPDALAELDGKTVAFEVE
                     RTVKSRRRYQEVVSGYLFNRKANGIDEIWYICPDRATQVRVQRAILSVDEIVNPQTGEA
                     RKTAELDRERLFACFKFMTTE"
                     /name="MobC family replication-relaxation protein"
     gene            4812..5342
                     /locus_tag="GJJ26_RS27250"
                     /old_locus_tag="GJJ26_027250"
     CDS             4812..5342
                     /locus_tag="GJJ26_RS27250"
                     /old_locus_tag="GJJ26_027250"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008321413.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_004153058.1"
                     /translation="MALYMVFIEDAEDRNGERCIMPTSEHLEDMVVLAWQTGAYVFCFV
                     DRAQHLAMMKSIGMYDERLNSDEKATYFFTGKNPQWERNKPTGMKLCDYLYRKVERFAI
                     ENGVQVVDAGKCSPEQINAMIDVVSERHGESAVNEKLKAELMREYNSRYFNVPVPELPE
                     DKPARRWWPFGKK"
                     /name="hypothetical protein"
     gene            complement(5370..5549)
                     /locus_tag="GJJ26_RS27255"
                     /old_locus_tag="GJJ26_027255"
     CDS             complement(5370..5549)
                     /locus_tag="GJJ26_RS27255"
                     /old_locus_tag="GJJ26_027255"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000165970.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rop family plasmid primer RNA-binding protein"
                     /protein_id="WP_000165971.1"
                     /translation="MTKQEKTALNMAKFIKEQSLLLLDKLNELDMDTPADMCERLHEDA
                     ETLWQVMRDKLGEE"
                     /name="Rop family plasmid primer RNA-binding protein"
     gene            5618..5995
                     /locus_tag="GJJ26_RS27260"
                     /old_locus_tag="GJJ26_027260"
     CDS             5618..5995
                     /locus_tag="GJJ26_RS27260"
                     /old_locus_tag="GJJ26_027260"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004146445.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000312627.1"
                     /translation="MAWVTVRQATELTGKARSSLYRDMAKGRVSYRTEADGGRVVDTSE
                     LIRVYGELRQDETHERDELRLSGETEKMASDALIAEIKALREEVAGLRQEMQSMRLLEH
                     KPETAETPAGTPRRWWPWGKR"
                     /name="hypothetical protein"
     gene            complement(6057..6356)
                     /locus_tag="GJJ26_RS27265"
                     /old_locus_tag="GJJ26_027265"
     CDS             complement(6057..6356)
                     /locus_tag="GJJ26_RS27265"
                     /old_locus_tag="GJJ26_027265"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001146176.1"
                     /GO_function="GO:0008657 - DNA topoisomerase type II
                     (double strand cut, ATP-hydrolyzing) inhibitor activity
                     [Evidence IEA]; GO:0042803 - protein homodimerization
                     activity [Evidence IEA]"
                     /GO_process="GO:0030541 - plasmid partitioning [Evidence
                     IEA]; GO:0051290 - protein heterotetramerization [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_001146176.1"
                     /translation="MPYDVEWKQGAIEDVTTLFDYIAENSSLWDAQNVTDRVLAAADKL
                     ADFPRLYEVDSRYGEDVRRISLMGQHVLYDVDDQTRKVRVLAVVGQRQNPHIVL"
                     /name="type II toxin-antitoxin system RelE/ParE family
                     toxin"
     gene            complement(6346..6609)
                     /locus_tag="GJJ26_RS27270"
                     /old_locus_tag="GJJ26_027270"
     CDS             complement(6346..6609)
                     /locus_tag="GJJ26_RS27270"
                     /old_locus_tag="GJJ26_027270"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000072676.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000072676.1"
                     /translation="MSNTTHYENANFLRELAESLPRILPEGGPDKAALLQRLANEELAQ
                     AEYEDQVRAKVTAARADTRPGMTTEQLRQRLHGRYQELRDAV"
                     /name="hypothetical protein"
     gene            complement(6915..7334)
                     /locus_tag="GJJ26_RS27275"
                     /old_locus_tag="GJJ26_027275"
     CDS             complement(6915..7334)
                     /locus_tag="GJJ26_RS27275"
                     /old_locus_tag="GJJ26_027275"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016247941.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Exc2 family lipoprotein"
                     /protein_id="WP_001254601.1"
                     /translation="MRRSGSKLCLIAMITATATLTACAPKGSVEQHTRHYVYASDDGFD
                     PNFSTQKADTTRMMVPFFRQFWDMGAKDKATGKSRSDVQQRIQQFHSQEFLNSLQGTTQ
                     FAGTDYRSKDLTPKKSRLLADTISAVYLDGYEGRQ"
                     /name="Exc2 family lipoprotein"
     gene            7737..>9294
                     /locus_tag="GJJ26_RS27280"
                     /old_locus_tag="GJJ26_027280"
     CDS             7737..>9294
                     /locus_tag="GJJ26_RS27280"
                     /old_locus_tag="GJJ26_027280"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010891190.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="colicin-like bacteriocin tRNase domain-containing
                     protein"
                     /protein_id="WP_191686160.1"
                     /translation="MSGGDGRGPGNSGLGHNGGQASGNVNGTSGKGGPSSGGGTDPNSG
                     PGWGTTHTPNGDIHNYNPGEFGNGGSKPGGNGGNSGNHSGSSGGGQSSATAMAFGLPAL
                     ATPGAEGLALSVSGDALSAAVADVLAALKGPFKFGLWGIAIYGVLPSEIAKDDPKMMSK
                     IVTSLPADTVTETPVSSLPLDQATVSVTKRVADIVKDERQHIAVVTGRPMSVPVVDAKP
                     TKRPGVFSVSIPGLPSLQVSVPKGVPAAKAPPKGIIAEKGDSRPAGFTAGGNSREAVIR
                     FPKESGQKPVYVSVTDVLTPAQVKQRLEEEKRRQQAWDAAHPEEGLKREYDKAKAELDA
                     EDKNIATLNSRIASTEKAIPGARAAVQEADKKVKEAEANKDDFVTYNPPHEYGSGWQDQ
                     VRYLDKDIQNQNEKLKAAQTSLNEMNESLSRDKAALSGAMESRKQKEKKAKDAENKLNE
                     EKKKPRKGTKDYGHDYFPDPKTEDIKGLGELKEGKPKTPKQGGGGKRARWYGDKKRKIY
                     EW"
                     /name="colicin-like bacteriocin tRNase domain-containing
                     protein"
     BGC             2737..9294
                     /name="RiPP-like"
                     /gene="RiPP-like"
                     /tool="antismash"
     Typing          complement(733..1311)
                     /name="ColRNAI_rep_cluster_1857"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="95.361"
                     /coverage="100.0"
                     /evalue="0.0"
     Typing          4075..4802
                     /name="MOBC"
                     /typing="relaxase"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="1.32e-150"
ORIGIN
        1 attcccagca cggtgagctt gaagggtacc gcgccagtga tggcgaacac ctcggggcat
       61 tcgatccaaa aacgggtaag caggttaaag ggccggatcc aaaacgaaac attaaaaaat
      121 atctttaaga ggtaaatatg gggcttaaat tacatattca ttggtttgat aagaaaaccg
      181 aagagtttaa aggtggtgaa tactcaaaag acttcggtga tgatggttct gtcattgaaa
      241 gtctggggat gcctttaaag gataatatta ataatggttg gtttgatgtt gaaaaatcat
      301 gggtttcgat attacagcca cactttaaaa atgtaatcga tattagtaaa tttgattact
      361 ttgtatcctt tgtttaccgg gatggtaact ggtaagcaaa agttatcaag gatgatttga
      421 aatacagact tccggtgttc agggatgaat accggggttt ttaaatacag ggaaggtata
      481 tgaaaaaggt aaaggttgtt tttcttttta tattgatttt ttcaggcttt cttctggtcg
      541 catgtcaggc aaactatatc cgggatgttc agggtggaac ggtggcacca tcgtcctcct
      601 ctgaactgac ggggatcgcg gttcagtaga aaagatcaaa ggatcttctt gagatccttt
      661 ttttctgcgc gtaatctttt gccctgtaaa cgaaaaaacc acctggggag gtggtttgat
      721 cgaaggttaa gtcagttggg gaactgctta accgtggtaa ctggctttcg cagagcacag
      781 caaccaaatc tgtccttcca gtgtagccgg actttggcgc acacttcaag agcaaccgcg
      841 tgtttagcta aacaaatcct ctgcgaactc ccagttacca atggctgctg ccagtggcgt
      901 tttgcgtgct tttccgggtt ggactcaagt gaacagttac cggataaggc gcagcagtcg
      961 ggctgaacgg ggggttcttg cttacagccc agcttggagc gaacgaccta caccgagccg
     1021 agataccaga gtgtgagcta tgagaaagcg ccacacttcc cgcaagggag aaaggcggaa
     1081 caggtatccg ggaaacggca gggttggaac aggagagcgc aagagggagc gattcatcgg
     1141 aaacggtgat gatctttaag tcctgtcggg tttcgccact cctgactgat tcatggttga
     1201 gccaccggct cccacagatg caccgaaaaa gcgtctgttt atgtgaactc agtcaggagg
     1261 gcggagccta tggaaaaacg ccacctgcgt ggccttgccg ttttgcctca catgttagtc
     1321 ccctgcttat tcacggaatc tgtgggtaac tttgcatgtg tccgcagcgc ccgccgcagt
     1381 ctcacggccg gagcgtagcg accgagtgag cgaggaggcg caatttcccc ggcacctaca
     1441 agacggacac cggacgcgct gatgtggcat attgtcccct gattaagtct ttatattccc
     1501 tgataataaa ttaccaggat aggtgaatca tatcggtttt tcgctgaaca ttttacgtta
     1561 acctatctct gttgcttttt tctccttacg gagaaataca ggtcatcccc gcgagggcgt
     1621 ggctgacctc agggggatat cccctgctta cgctggctgg acgccaccga cgcacggtct
     1681 ctccccctct ttctggctcc gtccggctgg acgccggcca cgccagaaat tcacccggcc
     1741 cccgtcaggc tcacgcctga ccacccacaa aaatccacgg tgctggacgc acctggcgaa
     1801 gcagcaaagc tgctcctgat tttgcgggtg gtcagccgct cgctatggcg aactctgacg
     1861 ggggccggaa caccggaaaa gaccgcactg gggtgccgcc ttttcctctc acacgctggg
     1921 gcgtgctcgt tgttcctccg gggctgcgcc ttttccgcat ggggcggaaa gaggctggcc
     1981 tccgtggtga aagctgaacg caatcaccac ggacgtgacc gccgccgcca tgccttgggg
     2041 catgtccgcg gcttgtgcag cgggggctgc acatcacgcc ggcaaaccat cgtctgaagg
     2101 agagagaaca tgtttaatac ggattcgctt gcctggaagt ggcacattcc ggagctggcc
     2161 cggcagattt atccgtgggt cagctggctg taccaggagt attacggtct ggccggggct
     2221 ttcctagtta tcggcctgtt tttcggtctg gctgaacttt gggccggacg gatgcgtttt
     2281 gtggggctga gtcataagga gcgacgggag tatgccgatc gctataagcg cgataataaa
     2341 cggccagcgc cattttcggt gctggcctcg ctggattcgc ccgggcggat ggtcagggca
     2401 cgtcgacatg tctggaacta cgcgtactgg ctgaccggcg cggccggtct ggcccttctg
     2461 ggggggctgg ttgtcgccgt gtttatcgag agctggggag aaaccgtcct gcgtccggac
     2521 ctctacgcaa acgcagatta ttacctgctg cagccggcta acctgttcgg gattgcctgg
     2581 tgcgcgggcg ggctggctgt cgggattgtg ttggcgcggc tgctggcgtt cctgctgctt
     2641 gacggtcatt ttgcggctgc tgacgaggcg gtgaacgcga aactgaatca ggagagccgg
     2701 cgcagcagcc agcggacagg agagatgacc gacgtgcgcc acctgcattt cggggagccg
     2761 gtaccggtta atgcgctggc cgatttttcc tcggagcagg cccggcagga gcaggcggtg
     2821 tttctgggta aggatgagca gggcaagccg gtgctggttc cgcgtgatac ctggcgcaag
     2881 accaacattc agatcctcgg cctgcccggg agcggcaaga gcgtgatggc caccaacgcg
     2941 ctcattcgct gcgtacgcga tttcggggac gcggtggtgt acttcgaccc caaaggggac
     3001 gcatgggcgc cgcacgtctt ccgggcgcac tgtccggact tcaccctgct ggatctgcgg
     3061 ccggggaaac cggcgcagct gaatctgttc cgcgatctcg accagtacgc gctgaaaaac
     3121 ctgctgattg ccgggcttaa cctgggcgag accggcgacg tggcggacca ctaccgcatc
     3181 agcgagcaga aagcggcgaa gctgattgcg gagcagtttc cgcagggggc aaacattcag
     3241 caggtgctgg cggcggcgta cgcgctgccg gaggccctga aaaaggacgt gaaggggttg
     3301 atcactaggc tggaaaacgt cgctgacctg agcgtcctgc agacggacag tggcatcgat
     3361 gtggcgggga ttatcaacgg cggcggctgc ctgtacgtta tcggctcgat ggacgacgag
     3421 gcggtgatcc gtgtgcaaaa aatgctgttt gcccgctgcg cgcaaatcat cattgcgcgg
     3481 gacgagttcc gggagtggcc acacgtcagc gtgatgctcg atgaaattaa atatctgctg
     3541 tcgaagtatg tactgaacgc actggggacg ctgcgcagcc gggactgcaa tctgttgctc
     3601 gcgcaccagt cgctgggcga tttcgggcag tgcgggcagg atctgcccgc tgaatttgtg
     3661 aaaaccacgg tactggataa cacgccgatc cgctggtttt accgggcggc cagcctggag
     3721 tccgcgcagt gggcggcggg gcagaccggg gaaatcaggg tggacgtgga gcgccgccgt
     3781 gccagccggg aggcggggaa cgtggagcat atcagcgggg acagcttcat ccagaaggag
     3841 gcgcggccgc tgtttgacgt gaacaccctg caacacctgc cggacgggtt cgcggtcatg
     3901 accgggctgg gtgtggcccg gatggcgttc agcagtccgc tgcgggttga gcgccgggaa
     3961 atcccgttgc agcgtttccc ggtgctggcg aaaaccgatc ccctggcgga gttccggccc
     4021 ccggccgacg gcggcgggcc gaaagcggat gatgattttg cggggattta ctgatggcgc
     4081 tggagctgta caacgtcagc cacgcgaaac gacaggcgcg gaacgcggag aaaacccggc
     4141 tgaccctgcg ctggttgcgg gaagagctgt gttccacggc ggagctggtt gcgcggcggc
     4201 tggggattgc ggcggtgcag ccggtctacc gcttcctcga cagcctggtg gcgaaagggc
     4261 tgctggtccg gaccaaatat ccggtggacg gccgtcaggt cagcgtgtgg gggctgacgc
     4321 cgcatggcgt ggcgttctcg ttcgacgagg acgaaccgct ggcggatgtt attccgtttc
     4381 agccgtcaag ggtgtcggca gcacatctgc cgcaccggct ggccgtgcaa tccctgcgcc
     4441 ttgatatgga agccagaggg gccaccggct ggcgcattct gcaccgtctg agtcttaaag
     4501 gcatgaaagt gccggacgcc ctggcggagc tggacggtaa aacggtggcg tttgaggtgg
     4561 agcgcaccgt caagagccgt cgccggtatc aggaagtggt gtccgggtat ctgttcaacc
     4621 gcaaagctaa cggcatcgat gaaatctggt acatctgccc ggaccgggcg acgcaggtca
     4681 gggtgcagcg ggcaatcctg tcggtggatg aaatcgtgaa cccacagacc ggcgaggccc
     4741 gcaaaacggc agagctggat cgtgaacggt tgtttgcgtg ctttaaattt atgacaacgg
     4801 agtgagggat tatggcgctg tacatggtat ttattgaaga cgcggaggac cggaacggcg
     4861 agcgctgcat catgccgacc agcgagcatc tggaagatat ggtggtgctc gcctggcaga
     4921 ccggggcgta tgttttctgt tttgtcgacc gggcccagca tctggcgatg atgaaatcca
     4981 tcgggatgta tgacgagcgg ctcaacagcg acgaaaaagc cacgtacttt ttcactggta
     5041 aaaatccgca atgggaacgg aacaaaccca caggaatgaa gctgtgtgat tacctctatc
     5101 gcaaggtgga gcggttcgcc atcgagaacg gtgtgcaggt ggttgatgcc gggaagtgct
     5161 caccggagca gattaacgcg atgattgacg tggtgagtga gcggcacggg gaaagcgcgg
     5221 tgaacgagaa gctgaaagcg gagctgatgc gggaatataa cagccgctat tttaacgtgc
     5281 cggtacctga actgccggag gacaaacctg cccgccggtg gtggccgttc ggcaaaaaat
     5341 aaatgccagc accggccatg ccggtgctgt tattcctccc cgagcttatc ccgcatcacc
     5401 tgccagagtg tttccgcatc ctcgtgtagc cgctcgcaca tgtcggccgg ggtatccata
     5461 tccagctcat tcagtttatc gagcaatagc agcgactgct ccttaataaa tttagccata
     5521 ttgagggctg ttttttcctg ttttgtcatg attctttcct tccgggcatg gtgtgcgcct
     5581 gtcaggtata ctgtctcaaa aatagcgggg tgagacaatg gcgtgggtga cggtgagaca
     5641 ggcgacggaa ctgacgggta aagcccgaag ttccctgtat cgggatatgg cgaaaggccg
     5701 cgtatcatac cgtacggaag ctgatggcgg ccgggtggtg gataccagcg agcttatccg
     5761 ggtgtacggt gagttaagac aggatgagac tcacgagcgg gacgagttga gactgtcggg
     5821 tgagactgaa aaaatggcct ccgacgcgtt gatcgcggag ataaaagcac tcagggagga
     5881 ggtggccggg ctacggcagg aaatgcagtc catgagactg ctggaacaca aaccggagac
     5941 agcagagacc ccggccggaa caccgcgccg gtggtggccg tggggaaaac gctgacgcgc
     6001 tgtgcttgtc caaccggcga cggccacgca atgaattgcg tccccgtcac cggttattag
     6061 agaacaatat ggggattctg gcgctggccg accacggcca gaacccggac ttttctggtc
     6121 tggtcatcaa catcatagag gacatgctgt cccatcagac tgatccggcg aacgtcctcg
     6181 ccatagcgtg agtccacttc atagagtcgc gggaagtcgg ccagtttgtc cgccgcagcg
     6241 agaacccggt cggtaacgtt ctgcgcatcc cacagggatg aattttccgc gatatagtca
     6301 aacagcgtcg ttacatcctc gatggctccc tgcttccatt ccacgtcata cggcatcgcg
     6361 cagttcctga taacggccat gcaggcgctg gcggagttgt tccgtggtca tacccggacg
     6421 cgtgtcagca cgggcggcgg tcactttggc gcgaacctga tcttcatact ctgcctgggc
     6481 cagttcttcg ttagccagtc gctgcaacag cgcagctttg tccgggccac cttccggcag
     6541 tatgcggggc aggctttcag ccagttcccg aagaaagttg gcgttttcgt agtgtgtagt
     6601 gttgctcatt gcggagcctc ccgggttaat gcggcaatat gaaggaagtt tagcaggggg
     6661 cggtctgaaa gaatatggtc gtgtcagtca ggctgatgaa gcagaaagtc ggtaaaaaag
     6721 ggcttacggc atccatttta cgtcaaaaca tatgccatgc agttgcgtgc ataggcatgc
     6781 attaggataa aatttatcgg gcgcgtttcc ggcagttttc cgggggggtt gttgcctgtt
     6841 ttatcccgta gccgccggaa acgccctgag cccgtctgag cggtgcgcgt aatgacgcgt
     6901 tatggtaaat ccacttactg tctgccttca tagccatcga gataaacagc tgaaatggtg
     6961 tcagccagta gccttgattt tttcggtgtg aggtctttgc tgcggtaatc ggtacccgca
     7021 aattgtgttg tgccttggag tgagtttaaa aattcctgac tgtgaaactg ctgaatgcgt
     7081 tgctgcacat cactccgtga ttttccggtc gctttatcct ttgcgcccat atcccagaac
     7141 tgccggaaaa aaggcaccat cattcgtgtt gtgtcagctt tctgggtgga aaaattggga
     7201 tcaaaaccgt catctgaagc atatacgtaa tgccgggtat gctgttccac gctgcccttt
     7261 ggagcacagg cagtgagagt tgctgtcgct gttatcatgg cgataagaca cagtttgctg
     7321 ccggaacgtc tcatgagcgt ctccttacct ttaattcttt tttctcattg agttatatat
     7381 ccgcaggcta tcttatcatc agtttctgac cgtgttcagt gaccgaacaa cccgaaccag
     7441 accccccgtt tcttttcctg tcccggaggg ggctttctgg tatctcatat aatgatttca
     7501 gtaaaacata ctgaggccgg agaacggcgc cgtttgtgct ggtttttgtt gcatctggag
     7561 gggattgcgc atggtgtgag tggctgtttt tttgatcatt ttcacaaaaa cgcaaattta
     7621 cagacttgac atgaaaaaca aggcagcgta atttttatac tgtatataaa accagtggtt
     7681 atatgtacag tattttattt tagtttattg ttttaaaagt caaagaggaa aagtatatga
     7741 gtggcggaga cggacgaggt ccgggtaatt caggtctggg acacaatggt ggtcaggcca
     7801 gtgggaatgt gaacggtaca tcaggtaaag gtggcccttc atcaggtggt ggtacggatc
     7861 caaacagcgg gccgggctgg ggtacgacgc atacacctaa cggggatatt cataactata
     7921 acccggggga gtttggtaac ggcgggagta aacccggtgg taatggcggt aacagcggca
     7981 atcatagcgg gagctctggt ggcggacagt cttcggccac cgcgatggcc ttcggtctgc
     8041 ctgccttggc cactccgggg gctgaaggac tggctttatc cgtttccggc gatgcgttgt
     8101 cggccgctgt tgctgatgtg ctggctgccc tgaaaggtcc gtttaagttt ggtctgtggg
     8161 ggattgcgat ttacggagtg ctgccttctg agatagcaaa agatgatccg aaaatgatgt
     8221 caaaaatcgt gacgtcattg ccggcagaca cggtaacgga gacgccggtc agctccctgc
     8281 cgctggacca ggcgacggtc agcgtcacta aacgtgtggc ggatattgtg aaggacgagc
     8341 ggcagcatat tgcggttgtc accggccggc caatgagtgt tcctgtggtg gatgcgaaac
     8401 cgacaaaacg tccgggggta ttcagtgtgt cgattccggg tctcccgtct ctgcaggtga
     8461 gcgtacctaa aggtgttccg gccgcgaaag ccccgccaaa aggcattatt gctgaaaaag
     8521 gtgattcacg tccggctggt tttacggccg gtggtaactc ccgtgaagcc gttattcgtt
     8581 tcccgaaaga gagcggacag aaaccggtct atgtgtcggt gacggatgtt cttactccgg
     8641 cacaggtaaa acagcgtctg gaggaagaaa agcgtcgcca gcaggcatgg gacgctgctc
     8701 acccggaaga ggggctgaaa agagagtatg ataaagcgaa agctgagctg gatgctgaag
     8761 ataaaaatat tgcgacctta aacagtcgca ttgcatcgac agagaaggcg atccccggtg
     8821 caagggctgc tgttcaggaa gccgataaaa aggtaaaaga ggcagaggca aataaagatg
     8881 attttgtgac ttataacccg cctcatgaat atggctccgg gtggcaggat caggttcgct
     8941 atcttgataa ggatattcag aatcagaatg agaaattaaa agctgcccag acatctttaa
     9001 acgaaatgaa tgaatcctta tccagggata aggctgcgct ttccggggcg atggagagcc
     9061 ggaaacaaaa ggagaaaaaa gcgaaggatg cagaaaataa attaaatgag gaaaagaaaa
     9121 aacctcgtaa gggaactaaa gattacggcc atgattattt tcctgatccc aagactgaag
     9181 atattaaggg gttgggagag ttgaaagagg gtaaacctaa aacccctaaa caaggtggtg
     9241 gtggtaagcg ggcccgatgg tatggtgata aaaagcgtaa aatttatgaa tggg
//
