LOCUS       NZ_CP061067             8428 bp    DNA     circular CON 10-JAN-2024
DEFINITION  Klebsiella pneumoniae strain HKP0018 plasmid pHKP0018.5, complete
            sequence.
ACCESSION   NZ_CP061067
VERSION     NZ_CP061067.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN15946735
            Assembly: GCF_014495785.1
KEYWORDS    RefSeq.
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
REFERENCE   1  (bases 1 to 8428)
  AUTHORS   Xanthopoulou,K., Carattoli,A., Wille,J., Biehl,L., Rohde,H.,
            Farowski,F., Krut,O., Villa,L., Feudi,C., Seifert,H. and
            Higgins,P.G.
  TITLE     Antibiotic resistance and mobile genetic elements in extensively
            drug-resistant Klebsiella pneumoniae sequence type 147 recovered
            from Germany
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8428)
  AUTHORS   Xanthopoulou,K., Carattoli,A., Wille,J., Biehl,L., Rohde,H.,
            Farowski,F., Krut,O., Villa,L., Feudi,C., Seifert,H. and
            Higgins,P.G.
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2020) Institute of Medical Microbiology,
            Immunology and Hygiene, University of Cologne, Goldenfelsstrasse
            19-21, Cologne 50935, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. v0.4.9b
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 85x
            Sequencing Technology :: Illumina MiSeq; Oxford Nanopore MinION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/10/2024 01:23:33
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,596
            CDSs (total)                      :: 5,471
            Genes (coding)                    :: 5,351
            CDSs (with protein)               :: 5,351
            Genes (RNA)                       :: 125
            rRNAs                             :: 9, 8, 8 (5S, 16S, 23S)
            complete rRNAs                    :: 9, 8, 8 (5S, 16S, 23S)
            tRNAs                             :: 89
            ncRNAs                            :: 11
            Pseudo Genes (total)              :: 120
            CDSs (without protein)            :: 120
            Pseudo Genes (ambiguous residues) :: 0 of 120
            Pseudo Genes (frameshifted)       :: 49 of 120
            Pseudo Genes (incomplete)         :: 66 of 120
            Pseudo Genes (internal stop)      :: 21 of 120
            Pseudo Genes (multiple problems)  :: 13 of 120
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP061067.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..8428
                     /organism="Klebsiella pneumoniae"
                     /mol_type="genomic DNA"
                     /strain="HKP0018"
                     /isolation_source="rectal swab"
                     /host="Homo sapiens"
                     /db_xref="taxon:573"
                     /plasmid="pHKP0018.5"
                     /geo_loc_name="Germany"
                     /lat_lon="53.4608 N 9.9836 E"
                     /collection_date="2015-02-16"
                     /collected_by="university hospital in northern Germany"
     gene            133..275
                     /locus_tag="IBX29_RS28190"
                     /pseudo=""
     CDS             133..275
                     /locus_tag="IBX29_RS28190"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001326446.1"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /name="replication initiation protein"
     gene            complement(484..687)
                     /locus_tag="IBX29_RS27710"
     CDS             complement(484..687)
                     /locus_tag="IBX29_RS27710"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000427298.1"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="cold shock domain-containing protein"
                     /protein_id="WP_072040881.1"
                     /translation="MEKGFINFYDHVRGYGFIRRECGRDVFFKHDDFFDFESSVDVCKG
                     IFVNFEVIKADKGLRAVNIRIV"
                     /name="cold shock domain-containing protein"
     gene            complement(692..1741)
                     /locus_tag="IBX29_RS27715"
     CDS             complement(692..1741)
                     /locus_tag="IBX29_RS27715"
                     /EC_number="2.7.7.49"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000900598.1"
                     /GO_function="GO:0003964 - RNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="reverse transcriptase family protein"
                     /protein_id="WP_225995896.1"
                     /translation="MVLSVSRSYKQFTVETGKNKKERKIFEPKRSLKGIQKKINKEIFE
                     NIDYPHYLHGAITGRDYISNASVHTKKKTIICLDITNFYPSISKRDVTLIFKNLMRFSP
                     DVSIALTELVTLNNQVPQGGCCSSYIANLLFFNSEYNLYNRLQSIGYSYTRLLDDITIS
                     SDEDISLEEKTKVIQLVYRMVSQHRLSINEDKTTIEHTKDSSSKLSVTGLWVKHGVPKL
                     TKENRRYIRYLVYICQKQAAYERHTKEYHDLWNRCSGKVAQMSRLGHVQANELRCVLSD
                     ILPIYDDYKIGKLKYVAKHYLSKFTHPLSEEQIRKVDRMIYDFDIVGRTNEKLAKDYRS
                     KLRALLPER"
                     /name="reverse transcriptase family protein"
     gene            complement(3365..3787)
                     /locus_tag="IBX29_RS27720"
     CDS             complement(3365..3787)
                     /locus_tag="IBX29_RS27720"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_005229777.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_039817119.1"
                     /translation="MARVSISEAARLVKVSRPTIYKMINSGKLSFTSVVKHGKAIKVID
                     TSELIRVFGSLDGVIDTVKYDVKSDAESTGVNSVGLHDLQHRIALLEAENDGLKGAVKA
                     RDEHIDSLRQAMQFLEHKHEPSSPSDSPWWKFWKKS"
                     /name="helix-turn-helix domain-containing protein"
     gene            complement(3787..3978)
                     /locus_tag="IBX29_RS27725"
     CDS             complement(3787..3978)
                     /locus_tag="IBX29_RS27725"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000166328.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rop family plasmid primer RNA-binding protein"
                     /protein_id="WP_039817117.1"
                     /translation="MTKQQKTALNMAKFIQHQSLLLLEKLNELDLDAEADLCEKLHDDA
                     EHLFRTLSSRLDELQDGN"
                     /name="Rop family plasmid primer RNA-binding protein"
     gene            4394..4507
                     /locus_tag="IBX29_RS27845"
                     /pseudo=""
     CDS             4394..4507
                     /locus_tag="IBX29_RS27845"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007772075.1"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /name="replication initiation protein"
     gene            4852..5967
                     /locus_tag="IBX29_RS27730"
     CDS             4852..5967
                     /locus_tag="IBX29_RS27730"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019405083.1"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA];
                     GO:0016887 - ATP hydrolysis activity [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ATP-binding protein"
                     /protein_id="WP_012579087.1"
                     /translation="MIKEISLKNFKCFNELYLKQLKTLNIIAGKNNYGKTSILDAIFCF
                     YDVKNPAVLLNIQAFRKEMAEINKNKPFWVSYFHDMDTSQKMSIVIRDERSEVTQTYET
                     ETNQRLESSLSLNVDTVLSNQNIPRQTIGSQATVNSLKINVTETPNAKNRVSNKLFSMQ
                     LKEDGVEIKSEIKNERDGINYKFKTATIITTSRKINKEATITNVSSLLTQKRKKDILEN
                     LKKIDDRIVDIAISAIGNNKEIYLDIGFSELNEISMLGEGISRALSFISSVLVQENSII
                     LIDEIENGIHYSVIKDIIKSLISSAKQNNNQIFATTHSQDVIRAINEIDSKNEDIAYIR
                     LGREKNSLKPTAVQFNMDDFSYSVENDWEVR"
                     /name="ATP-binding protein"
     gene            5967..6599
                     /locus_tag="IBX29_RS27735"
     CDS             5967..6599
                     /locus_tag="IBX29_RS27735"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000804504.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DUF3226 domain-containing protein"
                     /protein_id="WP_012579086.1"
                     /translation="MKDINNSKKIIFVEGDDDFHFLCNLLEIQGITDVFVEKINGKSKL
                     KQALRAFKNIDSFDEKESIFIILDADTSFSDTERSIIATLRELQISSPSSHNEIAMNGN
                     TKISFFIMPGKDKQGAIEDLIIEHASTRALYEYIIEFFEKIKNNKDDISASDKEYTYPT
                     NEKKAKVQVYLSCNRESDSRIGISMKNGIINTADNCFDEIKDFISKI"
                     /name="DUF3226 domain-containing protein"
     gene            6965..7207
                     /locus_tag="IBX29_RS27740"
     CDS             6965..7207
                     /locus_tag="IBX29_RS27740"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_098963735.1"
                     /translation="MHSAEIHTIQPGEVLFPAFFSSENGERGRNLLRGREALPAQPENR
                     FSAPSGIGFVDGRQSRYGKSPDDSPHDSPAIRIVN"
                     /name="hypothetical protein"
     gene            complement(7553..7954)
                     /locus_tag="IBX29_RS27745"
     CDS             complement(7553..7954)
                     /locus_tag="IBX29_RS27745"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009310048.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_012579088.1"
                     /translation="MARVSISEAARLTGKSRTTLHRLIKAGDLSTCSGERNAKMVDTSE
                     LLRVFGPFEQPKGEHHSGQVSGQRDTASADQSEQVIRHLKQEIEHLNTLLLSKDSHIDS
                     LKQAMLLLENHQAKLTESPAPWWKFWKKS"
                     /name="helix-turn-helix domain-containing protein"
     gene            complement(7954..8145)
                     /locus_tag="IBX29_RS27750"
     CDS             complement(7954..8145)
                     /locus_tag="IBX29_RS27750"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000166328.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Rop family plasmid primer RNA-binding protein"
                     /protein_id="WP_004187666.1"
                     /translation="MTKQQKTALNMAKFIQNQSLLLLEKLNELDLDVEADLCEKLHDDA
                     EHLFRTLSSRLDALQDGN"
                     /name="Rop family plasmid primer RNA-binding protein"
     Typing          13..422
                     /name="rep_cluster_2374"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="91.017"
                     /coverage="98.0"
                     /evalue="6.29e-156"
     Typing          4100..4507
                     /name="ColRNAI_rep_cluster_1987"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="95.599"
                     /coverage="99.0"
                     /evalue="0.0"
     Typing          8267..8428
                     /name="ColRNAI_rep_cluster_1987"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="89.571"
                     /coverage="99.0"
                     /evalue="7.02e-51"
ORIGIN
        1 atggctccct cgtgcgctct cctgttcctg cctttcggtt taccggtgtc attccgctgt
       61 tatggccgcg tttatctcat tccacgcctg acactcagtt ccgggaaggc agttcgctcc
      121 aagctggact gtatgcacga accccccgtt cagtccgact gctgcgcctt ttcggtaact
      181 atcaacttga gtccaacccg aaaagacacg acttatcacc actggcagca gccactggta
      241 acgcattcgc agaacaaaga agtgttgaag tgtgaggtaa actacagcta cactgttaga
      301 acgaattcgg tttctgtgct ctgcgaaagc cagttaccac ggttcagaaa cttgccggtt
      361 aatgaacctt cgaaaaaacc accttgccgg gtggtttttt cgtttacagg gcaagagatt
      421 acgacgagcg aggtaggatc tcaagagatc atttcatcaa aaaggctcaa aaacctctat
      481 attttataca attcgtatat ttacagccct aagcccttta tctgctttta ttacttcaaa
      541 attaacgaaa atccccttac atacatcaac actactttca aaatcaaaaa aatcatcatg
      601 cttgaaaaaa acgtcacgcc cacactccct tcgtataaaa ccatatcccc taacatggtc
      661 gtaaaagtta ataaaccctt tttccatata atcacctctc aggaagcaac gctctaagct
      721 tacttctata gtcttttgct agtttttcat tagttcgacc aactatatca aagtcataga
      781 tcattctatc aacttttctt atttgctctt cactcaaagg gtgcgtaaac ttacttaaat
      841 aatgcttagc cacatatttt aacttaccta ttttatagtc atcataaata ggcaatatat
      901 cagaaagaac gcaccttaac tcattagctt gaacatgccc aagccgagac atttgtgcaa
      961 ccttccctga acatctattc cataaatcat gatactcttt cgtatgccgc tcataagcag
     1021 cttgcttttg gcatatatac accaaatatc ttatatatcg tctattctct tttgttaatt
     1081 taggaacacc atgcttcacc cacaacccag tgacgctaag cttcgaagag gagtccttgg
     1141 tgtgctctat tgtcgtttta tcttcattta tggatagcct atgctgagaa accattctat
     1201 agacgagttg aattactttt gttttctctt ctaatgaaat atcctcatca gaggatattg
     1261 taatatcatc taacaacctt gtgtatgaat acccaataga ttgcaatcta ttataaagat
     1321 tatactcact attaaagaac aaaagatttg caatgtaact agagcaacac cctccttgcg
     1381 gaacttgatt attcaatgtc acaagctcag ttaaagcaat agatacatca ggagagaatc
     1441 gcattaaatt tttaaatata agagtaacat cccgcttact aatgcttgga taaaaattag
     1501 ttatatctag acatattatt gtttttttct ttgtgtgcac ggatgcattt gatatatagt
     1561 cacgcccagt tatcgcccca tgcaaataat gagggtaatc tatattttca aatatttctt
     1621 tatttatttt cttttgaata ccctttaaag atctcttggg ctcaaatatt tttctttctt
     1681 ttttattttt tcctgtttca acagtaaact gcttgtatga cctagatact gataagacca
     1741 tccagtccaa tcttttcctg tctataccta acatcgcagc caaagaatcc aaggatgcta
     1801 taggtgttcc attaaaccta ggtttattca tgatgtttga gttaaaagtc gattagttaa
     1861 agaattttga tatataatct aataatttaa caaaaatcaa gaacatacaa ccccaaaact
     1921 gcggggtttt cagcacttcc agagagccaa cctctctttt tttcttcttc tgtccgtctc
     1981 cggaacaaga tgaagagctc ttggttacgt aaatgttgat gttgaaaata aacatagtac
     2041 tgctcctagt ggttgtgaaa ttttgccaga ccataggaaa gcaaggaaaa attctattgg
     2101 ctctttggga cttttaactc acattgccag acaatcgtcg ccatttttga agcgataatg
     2161 agcgctcagg ggcgttctta ccgttaatgg gcggcaaggc cggtcatgat ctcatgtgag
     2221 atcgccttaa acaacaaggc atcggtttcc ttgacacaac ataaagcgta accatttttt
     2281 aaagagcgag agccaggcgt ggttcgcccg cttctctgat tattataaag ttttttatga
     2341 tgctgtcatc aaagaaaacg aacaagatga aaatccctcg tatagagggc ctgaatcatc
     2401 attacgtata aacttcagaa taaacgagca gcaaaagcca cgacaacacc ccctacactc
     2461 ccgttaacat tcgcaatggt tctcaggcga tcatccttga gaggcttgcc gtcaaaggtc
     2521 gcaatagttc ttaagcgatc atcttttata gttacactca caaatactca ataataagtt
     2581 aactttctga atttcctaag attaaatgaa aatggcatac aaccccattt aacataaggc
     2641 catgattgta cgcaccgcta aaacggcctc agggcgtttc tgacgggaaa ccggtaaaac
     2701 aggcaacaaa ccacccgaaa acccgccaga aacgcgcagg ctctgttttt acggcatgca
     2761 tgagtatgca cgcaagtgca tagcgcgaaa attcacgcca ttcagccagg gtaagtcctg
     2821 tttccggcgt tcttcccatc cgaaaacggt gaacggggac gcaatttatt gcgtggccgt
     2881 gaagcgttgc cggcgcagcc ggaaaaccgg ttttcagcac gttcaggaat cgggttcgtc
     2941 gacggccggc aatcacgtta tggcaagtcg ccggacgact caccacacga ttcaccggcg
     3001 actcttcact agagtcgtac ccagagtcgc cgcgtctaaa aaacaaccaa acggggagtc
     3061 gtgtctagag tcgggtcgtt attaacttat tgtttttata gtcctgagtc gttaccgact
     3121 ctatgacgac tcgccgggga ctctatgacg agtcgtcata gagtcggatc tatataaata
     3181 aaatttaaaa aacgaaattt caggaagtta acccactgat attaaataca aatatgcaaa
     3241 atgttaattt tgcgtagtgt gtgggtattt ttagtggtga ggagcgttca gagatctgac
     3301 gatttttggg aaggttcagg aactccccgg gatggccgga gaggaaaacg gaagcatgac
     3361 ggggtcagga ttttttccag aatttccacc acggggaatc ggatggtgaa gaaggttcgt
     3421 gcttgtgctc cagaaactgc attgcctgac gaagggaatc aatatgctca tctcgagcct
     3481 taacagcccc tttaagacca tcgttttcag cttcaagcaa agcaattcta tgttgtaaat
     3541 catgtaaacc aacgctgtta acacctgtag attctgcgtc actttttaca tcatatttta
     3601 cagtatcgat gacaccatcg agagaaccaa acactctaat aagctctgaa gtatcaataa
     3661 ctttaatagc cttcccgtgc tttacaacag aggtgaaact taacttccca ctgttaatca
     3721 tcttgtaaat tgtggggcga ctaaccttaa caagccgtgc cgcttcacta atagacactc
     3781 tggccatcag ttaccatcct gtaattcatc cagtctcgag gacagtgtac ggaaaagatg
     3841 ctccgcatca tcgtggagtt tctcacaaag gtcagcctca gcatcaagat caagctcgtt
     3901 aagcttctcc agcaggagca gagactgatg ctggatgaat ttagccatgt tcagcgcggt
     3961 cttctgttgt ttcgtcataa gaggcctcag agcgtcagtg ctcagtgtag ggatgttctc
     4021 ttttccgctt cctcgctcac tcagtcgcta tgctcctgcc gttcggctgc ggcgagcggc
     4081 aggagcatgc gtataaaagc tcgagaaaac cgagcggtcg cgtgacggtg aaaaggaaag
     4141 gccgctaagc ggccgttttt ccataggctc cgcccccctg acaagcatca cagaaactga
     4201 cgctcaaatc agtggtggcg aaacccgaca ggactataaa gatatcaggc gtttccccct
     4261 gatggctccc tcgtgcgctc tcctgttcct gcctttcggt ttaccggtgt cattccgctg
     4321 ttatggccgc gtttgtctca ttccacgcct gacactcagt tccgggtagg cagttcgctc
     4381 caagctggac tgtatgcacg aaccccccgt tcagtccgac tgctgcgcct aatccggtaa
     4441 ctatcgtctt gagtccaacc cggaaagaca cgacaaagcg ccactggcag cagccactgg
     4501 taactgattt agggagttag tcttgaagtt atacgccagt taaagctaaa ctaaacgaac
     4561 agttttggtg actgcgctcc ctttaagcca gttacctcgg ttcatagagc gccaactcta
     4621 ctgaaccttt cgaaaaaacc gcccgccaag gcggtttttt tcgttcacag ccggaagctt
     4681 acggctgctg ccagataatc tcaagaagaa agtaaaaaaa atcgattaaa acacaagcaa
     4741 tcaaagttaa tctttgacat aaagtctagc taatcacaat gaaagctgta cattttatta
     4801 aggtactaac aaatcgtatg gcatataaca aaaacacgaa cagaggctat catgataaag
     4861 gaaataagtt taaagaactt caaatgcttc aatgagctat atctaaagca attaaagact
     4921 ttaaatatca tagctgggaa aaacaactac gggaaaacat ctatactgga tgctattttt
     4981 tgtttttatg atgtaaaaaa cccggctgtt ttgttaaaca ttcaagcatt cagaaaagaa
     5041 atggcagaaa taaacaaaaa caagccattt tgggttagtt actttcatga tatggacaca
     5101 tcacaaaaga tgtccatagt cattcgagat gaacgctctg aagtaacaca aacatatgaa
     5161 acagaaacaa atcagagatt agaatcaagt ttgtctctaa acgttgacac cgtactatct
     5221 aaccaaaaca tacctcgtca aactatcggt tctcaggcca cagtaaactc tttaaaaata
     5281 aatgtgaccg agacacccaa tgcgaaaaac agggtttcca ataagctttt ctctatgcaa
     5341 ttgaaagaag atggcgtaga aataaaatcc gaaataaaaa acgaaaggga tgggattaat
     5401 tataaattta agacagcaac aataataaca acatccagaa agataaacaa agaggcaaca
     5461 attacaaatg tatctagcct actaacacaa aaaaggaaaa aagacatact agaaaactta
     5521 aaaaaaatag atgacagaat tgtagatata gcaatatctg cgataggtaa caataaggaa
     5581 atatatttag acattggatt tagtgagcta aatgaaatat caatgcttgg cgagggtatc
     5641 agtcgagcat tatcttttat cagctcagtg ctggtacagg aaaactcaat tattcttatt
     5701 gatgaaatcg agaacggaat acattactca gtaattaaag acataataaa atcattaatt
     5761 tcatctgcaa aacaaaacaa caatcaaata tttgcaacaa ctcatagtca agatgtgata
     5821 cgagcaataa acgaaataga tagcaaaaat gaagatatcg cttatattag actaggaaga
     5881 gaaaagaact ccctaaaacc aacagccgta caattcaata tggatgattt ctcctactca
     5941 gttgagaacg actgggaggt aagataatga aagacataaa taatagcaaa aagatcattt
     6001 tcgttgaggg tgatgatgat tttcattttc tatgcaacct acttgaaata caaggcatta
     6061 ccgatgtttt tgtcgaaaaa ataaatggaa aatcaaaatt aaaacaagca cttagagcat
     6121 tcaaaaacat tgattctttc gatgaaaaag aaagtatttt tattatatta gatgctgaca
     6181 catcattttc tgacacagaa agatcaataa ttgccacatt gcgagaacta caaatctcct
     6241 cccccagctc gcataacgag atagctatga atggcaatac aaaaatttct ttctttataa
     6301 tgccaggaaa agacaagcaa ggtgccattg aagatctgat aattgaacac gcaagcactc
     6361 gagcgttata tgaatacata atagaatttt tcgaaaaaat taaaaataat aaagatgaca
     6421 tctcagcgag tgacaaagag tacacttatc caacaaacga aaaaaaagct aaggtacaag
     6481 tctatcttag ctgcaataga gaatccgact caagaatagg aatatccatg aaaaatggaa
     6541 taataaacac agcagacaat tgctttgatg aaataaaaga ttttatttca aaaatataaa
     6601 tccaaatcaa gccagccctt cacgggctgg cttatcacca gggtgttatt aaacgccgga
     6661 taacgtatag aaagcatcat acactttagt tatcagcaat ctcaaacgtc ctaaagacat
     6721 caccagatgc caaaacaatg attgtgcaga tctaatgtaa aagacccagc acaagatgct
     6781 cccttaagtt atattctctc tattcactta aaacaattta acataaaatc ataattgtac
     6841 gcaccgctaa aacggactca ggacgtttct gacgggaaac cggtaaaaca ggcaacaaac
     6901 cacccgaaaa cccgccagaa acgcgcaggc tctgttttta cggcatgcat gagtatgcgc
     6961 gcaagtgcat agcgcggaaa ttcacaccat tcagccaggg gaagtcctgt ttccggcgtt
     7021 cttctcctcc gaaaacggtg aacggggacg caatttattg cgtggccgtg aagcgttgcc
     7081 ggcgcagccg gaaaaccggt tttcagcacc ttcaggaatc gggttcgtcg acggccggca
     7141 atcacgttat ggcaagtcgc cggacgactc accacacgat tcaccggcga ttcgaatcgt
     7201 gaattgaatc aagagtcacc atgagcaaaa aacacccaaa gtgatgaatt gaatcaagag
     7261 tcgattcatc ataacaatat gataataaag cgtgattcac atatgaatcg tgggcaattc
     7321 gtcagcgatt cgccatagag tcgtccacga cttggatctg cactttgtaa cacatcaccg
     7381 cacatttatt tttcattaac ccattgttgt aaataaggaa tctgcaaaat tttaattttg
     7441 cgtggggtgt gggtattttt agtggtgagg agcgttcaga gatctgacga tttttgggaa
     7501 ggttcaggaa ctccctggga tggccggaga ggaaaactga agcatgacgg ggtcaggatt
     7561 ttttccagaa tttccaccat ggcgccgggg attcagttaa ttttgcctgg tgattttcaa
     7621 gaaggagcat ggcctgtttc aggctgtcaa tgtgcgaatc cttggacaaa agtaaggtgt
     7681 tcaggtgttc aatctcctgt ttcagatgac ggatcacctg ttcactctgg tcagcagagg
     7741 ctgtatcacg ctgtccagag acctgtccag aatggtgttc acccttcggt tgctcaaagg
     7801 ggccaaagac acgtaaaagc tctgaagtat ctaccatttt tgcattgcgc tcaccgctac
     7861 aggtggacag gtcacctgct ttaattaacc tgtgcagtgt tgttctactc ttacccgtca
     7921 gtcgggcagc ctcactaata gacactctgg ccatcagtta ccatcctgta atgcatccag
     7981 tctcgaggac agtgtacgga aaagatgctc cgcatcatcg tggagtttct cacaaaggtc
     8041 ggcctcgaca tcgagatcaa gctcgttaag cttctccagc aggagcagag actgattctg
     8101 gatgaattta gccatgttca gcgctgtttt ctgttgtttc gtcataagag gcctcagagc
     8161 gtcagtggtc agtgtaggga tctcctcttt tccgcttcct cgctcactca gtcgctacgc
     8221 tcctgccgtt cggctgcggc gagcggcagg agcatgcgta gaaacgctcg agaaaaccga
     8281 gtaatcgcat ggaggaaaga aggaaaggcc gcacagcggc cgtttttcca taggctccgc
     8341 ccccctgacg agcatcacgg aatctgacgc tcaaatcagt ggtggcgaaa cccgacagga
     8401 ctataaagat accaggcgtt tccccctg
//
