LOCUS       NZ_CP060936            24944 bp    DNA     circular CON 24-MAY-2024
DEFINITION  Escherichia coli strain EC12 plasmid pEC12-NDM-5, complete sequence.
ACCESSION   NZ_CP060936
VERSION     NZ_CP060936.1
DBLINK      BioProject: PRJNA224116
            BioSample: SAMN15904656
            Assembly: GCF_022558865.1
KEYWORDS    RefSeq.
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Escherichia.
REFERENCE   1  (bases 1 to 24944)
  AUTHORS   Ruan,Z.
  TITLE     Complete genome sequence of carbapenem resistant Escherichia coli
            isolates
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 24944)
  AUTHORS   Ruan,Z.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-AUG-2020) Department of Clinical laboratory, Sir Run
            Run Shaw Hospital, School of Medicine, Zhejiang University, 3
            Qingchun East Road, Hangzhou, Zhejiang 310016, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. 0.4.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_022558865.1-RS_2024_05_24
            Annotation Date                   :: 05/24/2024 04:23:08
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,209
            CDSs (total)                      :: 5,085
            Genes (coding)                    :: 4,828
            CDSs (with protein)               :: 4,828
            Genes (RNA)                       :: 124
            rRNAs                             :: 8, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 93
            ncRNAs                            :: 9
            Pseudo Genes (total)              :: 257
            CDSs (without protein)            :: 257
            Pseudo Genes (ambiguous residues) :: 0 of 257
            Pseudo Genes (frameshifted)       :: 74 of 257
            Pseudo Genes (incomplete)         :: 187 of 257
            Pseudo Genes (internal stop)      :: 43 of 257
            Pseudo Genes (multiple problems)  :: 43 of 257
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP060936.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..24944
                     /organism="Escherichia coli"
                     /mol_type="genomic DNA"
                     /strain="EC12"
                     /isolation_source="urine"
                     /host="Homo sapiens"
                     /db_xref="taxon:562"
                     /plasmid="pEC12-NDM-5"
                     /geo_loc_name="China: Hangzhou"
                     /collection_date="2016-08-09"
                     /collected_by="Long Sun"
     gene            join(24451..24944,1..64)
                     /locus_tag="H9199_RS25755"
                     /old_locus_tag="H9199_25480"
     CDS             join(24451..24944,1..64)
                     /locus_tag="H9199_RS25755"
                     /old_locus_tag="H9199_25480"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_005221001.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_001235713.1"
                     /translation="MRLFGYARVSTSQQSLDLQVRALKDAGVKANRIFTDKASGSSTDR
                     EGLDLLRMKVEEGDVILVKKLDRLGRDTADMIQLIKEFDAQGVAVRFIDDGISTDGDMG
                     QMVVTILSAVAQAERRRILERTNEGRQEAKLKGIKFGRRRTVDRNVVLTLHQKGTGATE
                     IAHQLSIARSTVYKILEDERAS"
                     /name="recombinase family protein"
     gene            247..1107
                     /locus_tag="H9199_RS25760"
                     /old_locus_tag="H9199_25485"
     CDS             247..1107
                     /locus_tag="H9199_RS25760"
                     /old_locus_tag="H9199_25485"
                     /EC_number="3.5.2.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032489893.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="broad-spectrum class A beta-lactamase TEM-1"
                     /protein_id="WP_000027057.1"
                     /translation="MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYI
                     ELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYS
                     PVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRW
                     EPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSA
                     LPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGAS
                     LIKHW"
                     /name="broad-spectrum class A beta-lactamase TEM-1"
     gene            <1257..1430
                     /locus_tag="H9199_RS25765"
                     /old_locus_tag="H9199_25490"
                     /pseudo=""
     CDS             <1257..1430
                     /locus_tag="H9199_RS25765"
                     /old_locus_tag="H9199_25490"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000343760.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="transposase"
                     /name="transposase"
     gene            complement(1519..2181)
                     /locus_tag="H9199_RS25770"
                     /old_locus_tag="H9199_25495"
     CDS             complement(1519..2181)
                     /locus_tag="H9199_RS25770"
                     /old_locus_tag="H9199_25495"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001549893.1"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA];
                     GO:0000150 - DNA strand exchange activity [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="recombinase family protein"
                     /protein_id="WP_001549893.1"
                     /translation="MTQTVPKGFVRAYLRASTTEQDATRALDTINTFAIERGLSICNYY
                     IENESGSKLERPELFRLLKDCQQNDILLVEDVDRLSRLVGEDWNTLKKMIRQKDIRVVA
                     VNVPTTWLASGHNDFDSRMFSAINDMLLDMLAAVARRDYEQRRERQQQGIARAKREGKY
                     KGRQVNQSRYDAINRLIASGSSWSQIQKVLGCSRATISKAVKQQTVNKMNHEPEGRE"
                     /name="recombinase family protein"
     gene            2562..3224
                     /locus_tag="H9199_RS25775"
                     /old_locus_tag="H9199_25500"
     CDS             2562..3224
                     /locus_tag="H9199_RS25775"
                     /old_locus_tag="H9199_25500"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000516401.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="division plane positioning ATPase MipZ"
                     /protein_id="WP_000516402.1"
                     /translation="MGKILLVVSDKGGVGKSTYVANTGSMLVNKGKSVIILKTDKNHDL
                     LSWNEKRTDNGLLTIPVHAAYGNVSNEIKRLSKLCEVLIVDCPGHDSQEFRSALTVSDI
                     VVTLVKPSSDFESETLTSVTEKIRTAQKANAALEPWVLFTRINSAKPRHRKAAIDLDKL
                     LRSDNIWIQPLKTRISELDVYESACNEGAGVHDVSRASSLSTAKAQIELVAQEIGIL"
                     /name="division plane positioning ATPase MipZ"
     gene            3324..3608
                     /locus_tag="H9199_RS25780"
                     /old_locus_tag="H9199_25505"
     CDS             3324..3608
                     /locus_tag="H9199_RS25780"
                     /old_locus_tag="H9199_25505"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001371664.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001185481.1"
                     /translation="MALKLNRPNIDESQQPATNAETARFISGATRAPVAGKPKLMNFRL
                     PAYFEEILEAEAQRTGQSKTTVLKAALAAFDNLDENLKNHWLLESAKLG"
                     /name="hypothetical protein"
     gene            3814..4125
                     /locus_tag="H9199_RS25785"
                     /old_locus_tag="H9199_25510"
     CDS             3814..4125
                     /locus_tag="H9199_RS25785"
                     /old_locus_tag="H9199_25510"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000469598.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000469598.1"
                     /translation="MFIFRYIKTLINIYLLYIQPILGMFLIGIGLWGFYAPDEGTCTNL
                     NIELCAVSAIDVLKPAIFVFLGIITVAGWYFTELQPKLRGEGKYMKVKTGVKPEDFVK"
                     /name="hypothetical protein"
     gene            4161..4445
                     /locus_tag="H9199_RS25790"
                     /old_locus_tag="H9199_25515"
     CDS             4161..4445
                     /locus_tag="H9199_RS25790"
                     /old_locus_tag="H9199_25515"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001043731.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001043731.1"
                     /translation="MNKSWLEQQVQNEKLKKVQEEKKDGTIQKGLYRVRIKDKYRWDLW
                     ENDFRVVIAYSKDDAELKFTEMTGFNEHYYIESIEKIVLSDIEKILLEN"
                     /name="hypothetical protein"
     gene            complement(4466..4819)
                     /gene="ddp1"
                     /locus_tag="H9199_RS25795"
                     /old_locus_tag="H9199_25520"
     CDS             complement(4466..4819)
                     /gene="ddp1"
                     /locus_tag="H9199_RS25795"
                     /old_locus_tag="H9199_25520"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000202950.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DNA distortion polypeptide 3"
                     /protein_id="WP_000877224.1"
                     /translation="MKYQVKEFINEKYSKAVNILKDNLKEHYHIFYGLRLSEILFPASE
                     YGSEMFFQEFEAINSVILPLVIFDLIDRKPIMVIGFGEVCGVDSLVDSGIEVVSLDGLS
                     DLLLVEKLTPLFN"
                     /name="ddp1"
     gene            complement(5007..5450)
                     /locus_tag="H9199_RS25800"
                     /old_locus_tag="H9199_25525"
     CDS             complement(5007..5450)
                     /locus_tag="H9199_RS25800"
                     /old_locus_tag="H9199_25525"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001074369.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001074369.1"
                     /translation="MAKIYEFPQGAERSKLKKEIIRERKKRLRETNGNPVIRHAKWFWF
                     YLRLATAGALHLVSVISLAVLGAFSKAIFWIGGMLCVVTWFHLERQFWTPQNFTIPVIV
                     TLWGLSLFATPLMELLNKKMPWYRLLVPDAKHTSTEATNDDQP"
                     /name="hypothetical protein"
     gene            complement(5459..6472)
                     /locus_tag="H9199_RS25805"
                     /old_locus_tag="H9199_25530"
     CDS             complement(5459..6472)
                     /locus_tag="H9199_RS25805"
                     /old_locus_tag="H9199_25530"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001348704.1"
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006270 - DNA replication initiation
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="replication initiation protein"
                     /protein_id="WP_001348704.1"
                     /translation="MRLLLSLDMKILRSSYLKVRGFLIKGCIVVLNYNLCGVMICLHRK
                     GYMRLIVKTVTGLTKVRHRNEVGVTLASLSLSAKRVLFLALCQIDTKEMLDDDILEVDA
                     DFFSKATSLDKYASYAALKEGAKVLSSTTLVLNRDDLKNLADELGILSSKNKIPDRLDL
                     NLTEFCAYYDHLATVRIKFTNTAKRYFSKLIGSENRYTTQVLKSVVLLNSVNSTNLYQV
                     IRKYYSQNSSKKSFDISVDDLKEEMGLYTIEEGEKKYKYPKYSFFVRDVINKSINEIIE
                     KTEINQLSFSVVGKKGRMAHMLRFEFSINEKSSSFSEDDMAFLEEFDKVVPPKKNK"
                     /name="replication initiation protein"
     gene            <7083..7235
                     /locus_tag="H9199_RS25810"
                     /old_locus_tag="H9199_25535"
                     /pseudo=""
     CDS             <7083..7235
                     /locus_tag="H9199_RS25810"
                     /old_locus_tag="H9199_25535"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000127484.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="DNA-binding protein"
                     /name="DNA-binding protein"
     gene            complement(7413..7571)
                     /locus_tag="H9199_RS25815"
                     /old_locus_tag="H9199_25540"
     CDS             complement(7413..7571)
                     /locus_tag="H9199_RS25815"
                     /old_locus_tag="H9199_25540"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_152913118.1"
                     /translation="MRAITPLTPARPISDYQTMFSLSQLARELANGTPGQCETLARGAV
                     SARYEMR"
                     /name="hypothetical protein"
     gene            7825..8340
                     /locus_tag="H9199_RS25820"
                     /old_locus_tag="H9199_25545"
     CDS             7825..8340
                     /locus_tag="H9199_RS25820"
                     /old_locus_tag="H9199_25545"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001025391.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="DnaJ domain-containing protein"
                     /protein_id="WP_001025390.1"
                     /translation="MNIQEALNVFGLSGDLTEKDIKAAYKKAALKYHPDRNPLGAELMK
                     AVNAAFDFLMANIDKINQFQSTDENARYNYGEDLEKVLNTLSGLTGIVYEVIGNWVWIS
                     GETKEHKDILKEMGCKWASKKKQWFYRPEEHKSRWNRKEHSIEEIREMYGTAGKRKASG
                     WTRVEASA"
                     /name="DnaJ domain-containing protein"
     gene            8399..8635
                     /locus_tag="H9199_RS25825"
                     /old_locus_tag="H9199_25550"
     CDS             8399..8635
                     /locus_tag="H9199_RS25825"
                     /old_locus_tag="H9199_25550"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006122499.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000792381.1"
                     /translation="MKNKTITEAELINIFESYGAYICPDEIEVTAKECNENGSVLHRGL
                     NAEGWAHLFAKEEAYQQECEAQEAASDDGHFDE"
                     /name="hypothetical protein"
     gene            8695..9246
                     /locus_tag="H9199_RS25830"
                     /old_locus_tag="H9199_25555"
     CDS             8695..9246
                     /locus_tag="H9199_RS25830"
                     /old_locus_tag="H9199_25555"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001549906.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000662998.1"
                     /translation="MKEQKNFFERYKPVFEIVCRILGNGWRVNLLDDCQYRIKLTSPDF
                     KNYSIHIRMEKGRLVIIGSVDSRSWRSPYHTCTVSPERNPVEIAADIEKKILSDALDNV
                     DMAREYEQQLQQKREKKLILKGMLSRLVHLESWHGTLTGFKVENGLDGNVSERGDGYEM
                     VIRGLSVDQLIKVAGFIKQL"
                     /name="hypothetical protein"
     gene            9255..9524
                     /locus_tag="H9199_RS25835"
                     /old_locus_tag="H9199_25560"
     CDS             9255..9524
                     /locus_tag="H9199_RS25835"
                     /old_locus_tag="H9199_25560"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001549907.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001006717.1"
                     /translation="MNEVLSDRKNKGNVTYRIVVSEDATRLFIELEKLMKVRSKEADKK
                     TTKKIVFQKSFYYEEFSNVKDEIDDPILLKFYTDTIVKVQNHEF"
                     /name="hypothetical protein"
     gene            9514..9756
                     /locus_tag="H9199_RS25840"
                     /old_locus_tag="H9199_25565"
     CDS             9514..9756
                     /locus_tag="H9199_RS25840"
                     /old_locus_tag="H9199_25565"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000008707.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000008707.1"
                     /translation="MSFKPTPEEVKQARIKAGFTQQEAAERFGFTLSAWQAKETSGKTS
                     RGLAAGTYELLLLLADEHPDYQLVKREKNQDKVTK"
                     /name="hypothetical protein"
     gene            9850..10188
                     /locus_tag="H9199_RS25845"
                     /old_locus_tag="H9199_25570"
     CDS             9850..10188
                     /locus_tag="H9199_RS25845"
                     /old_locus_tag="H9199_25570"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001549908.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001099725.1"
                     /translation="MNTYVITFQALNTKKEKITCSAFVHSETLFLAVHSFEDKNRGRGY
                     VITSVSELLSEELTAKNSLKKNINFWFNECGLSKSEVINEVINWKNFAYTLKELEEAKN
                     EAIRELRS"
                     /name="hypothetical protein"
     gene            10263..10427
                     /locus_tag="H9199_RS25850"
                     /old_locus_tag="H9199_25575"
     CDS             10263..10427
                     /locus_tag="H9199_RS25850"
                     /old_locus_tag="H9199_25575"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000004083.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_000004083.1"
                     /translation="MSERMLSAIQTVEKGGRPVFPLMPFSAFPEYMALLRKALEKKETK
                     ALIEKQEVL"
                     /name="hypothetical protein"
     gene            10424..10681
                     /locus_tag="H9199_RS25855"
                     /old_locus_tag="H9199_25580"
     CDS             10424..10681
                     /locus_tag="H9199_RS25855"
                     /old_locus_tag="H9199_25580"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001549910.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_004199355.1"
                     /translation="MKKQEFLDFISAEQRRGAVRFSLGFNSKGEIVLHWTNEAGLRVWS
                     ILSGNRGKSPSRANRERMSNLRRWLHDARQGMEGDTPEAE"
                     /name="hypothetical protein"
     gene            11174..14191
                     /locus_tag="H9199_RS25860"
                     /old_locus_tag="H9199_25590"
     CDS             11174..14191
                     /locus_tag="H9199_RS25860"
                     /old_locus_tag="H9199_25590"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032490160.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Tn3-like element IS3000 family transposase"
                     /protein_id="WP_004199413.1"
                     /translation="MAFEERVQILSEAEQDELYGPPAFTSADQRFFFSLNDKELAIAKS
                     LRHRGQRYMLVVLLGYFKAKPVVLNPGFHQIKQDLKYVYQTVLPGPGCRPFNLTPKENE
                     RIYQRVFQLCNYQRWNVKDHGAALRDYLSQQARAWTAPRHLFDAANEYCSGQKIAIPAY
                     STLQKIISQVVGDEQEHMAAHLERAMSRGLKQALAELVNGTGPLPFRQLRQSARNFTGT
                     ELEKELIVYRHIQHWMPEVDLLLSTLSLSQKNLQHLAEKVDYYGAKLKRQTVGSQWLYL
                     LCYLQTRWQQALERIADGFVHHVRQTKQKAKDYAQEAVFKDWQKAAKNVSKAAEVLHLF
                     IDDSIDLQLPFATVRQQALSLLTKRDLESVCLFLNEQRRSVDEAMWQYCDEKESLRKGL
                     LRELFLCLRFEGCDGTQHLAAALAKTQNELNGQDAQLQTADTRLLSKKSREFLLDGEGN
                     ILIDRYEWFLYQQIPDRLNGQLTLPDITKYRALDADLIDGEHWRKNKYTLLQQSHFTKL
                     AEEPEKLIKQMAMELDTRLYEVGEYLEQEDNRNIILRNPQGKRFWRLPSASKHHLVNNP
                     FFQQIPTTGIADVLRMVDRDTGFIDCFAHVLGSQSRSRSHEYDLLAILVGNATNQGIYG
                     MAQISDRTYDQLSTIQANYLRLETLNAANDNINNATAKLPIFRYYNIQEDVIHASADGQ
                     KFEARRETFKTRYSSKYFGTQKGVSAMTLIANHAAINARVIGANEHESHYIFDLLMSNT
                     SDIIPDVLSTDTHGVNHVNFALLDLFGYQFAPRYAQVGKVINDMFDVKEDKEHRIQLCL
                     KKPINTHRIAQHWDTIQRIAVSLKQRKTTQATLVRKLSEYKRNHPLLEALTEYNRLVKA
                     NYLLCYIDDASLRNYVQRALNRGEAYHQLRRAVSSVNGDQFRGSSDEEIQLWNECARLV
                     TNAIVYFNSRILSQLLTSFEYQGDTKRIDIVKQASPVAWHNINLKGTYHFELSEKLPDL
                     EELMRSIEGYLPVSEK"
                     /name="Tn3-like element IS3000 family transposase"
     gene            complement(14482..15462)
                     /locus_tag="H9199_RS25865"
                     /old_locus_tag="H9199_25595"
     CDS             complement(14482..15462)
                     /locus_tag="H9199_RS25865"
                     /old_locus_tag="H9199_25595"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_416498.2"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS5-like element IS5 family transposase"
                     /protein_id="WP_000019402.1"
                     /translation="MSHQLTFADSEFSSKRRQTRKEIFLSRMEQILPWQNMVEVIEPFY
                     PKAGNGRRPYPLETMLRIHCMQHWYNLSDGAMEDALYEIASMRLFARLSLDSALPDRTT
                     IMNFRHLLEQHQLARQLFKTINRWLAEAGVMMTQGTLVDATIIEAPSSTKNKEQQRDPE
                     MHQTKKGNQWHFGMKAHIGVDAKSGLTHSLVTTAANEHDLNQLGNLLHGEEQFVSADAG
                     YQGAPQREELAEVDVDWLIAERPGKVRTLKQHPRKNKTAINIEYMKASIRAKVEHPFRI
                     IKRQFGFVKARYKGLLKNDNQLAMLFTLANLFRADQMIRQWERSH"
                     /name="IS5-like element IS5 family transposase"
     gene            15697..16509
                     /locus_tag="H9199_RS25870"
                     /old_locus_tag="H9199_25600"
     CDS             15697..16509
                     /locus_tag="H9199_RS25870"
                     /old_locus_tag="H9199_25600"
                     /EC_number="3.5.2.6"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032492661.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="subclass B1 metallo-beta-lactamase NDM-5"
                     /protein_id="WP_023408309.1"
                     /translation="MELPNIMHPVAKLSTALAAALMLSGCMPGEIRPTIGQQMETGDQR
                     FGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLLVDTAWTDDQTAQILNW
                     IKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGLVAAQHSLTF
                     AANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLG
                     DADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR"
                     /name="subclass B1 metallo-beta-lactamase NDM-5"
     gene            16513..16878
                     /gene="ble"
                     /locus_tag="H9199_RS25875"
                     /old_locus_tag="H9199_25605"
     ARG             16514..16875
                     /name="ble"
                     /gene="ble"
                     /gene_name="bleomycin binding protein Ble-MBL"
                     /tool="amrfinderplus"
                     /drug_class="BLEOMYCIN"
                     /identity="100.0"
                     /coverage="100.0"
     gene            16883..17521
                     /locus_tag="H9199_RS25880"
                     /old_locus_tag="H9199_25610"
     CDS             16883..17521
                     /locus_tag="H9199_RS25880"
                     /old_locus_tag="H9199_25610"
                     /EC_number="5.3.1.24"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004201168.1"
                     /GO_function="GO:0004640 - phosphoribosylanthranilate
                     isomerase activity [Evidence IEA]"
                     /GO_process="GO:0000162 - tryptophan biosynthetic process
                     [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="phosphoribosylanthranilate isomerase"
                     /protein_id="WP_004201168.1"
                     /translation="MPAKIKICGISTPEALDATIAARADYAGLVFYPASPRAVTSNVAG
                     ALTSRAAGQIAMVGLFVDADDAVIADALVAAKLNALQLHGSESPERVAQLRARFGKPVW
                     KALPVASASDVARAAAYAGAADLILFDAKTPKGALPGGMGLAFDWSLLAGYRGALPWGL
                     AGGLNPTNVAEAIARTGAPLVDTSSGVESAPGVKDTDKITNFAFAVRLA"
                     /name="phosphoribosylanthranilate isomerase"
     gene            complement(17532..>18089)
                     /locus_tag="H9199_RS25885"
                     /pseudo=""
     CDS             complement(17532..>18089)
                     /locus_tag="H9199_RS25885"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006399920.1"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="twin-arginine translocation (TAT) pathway signal
                     sequence domain protein"
                     /name="twin-arginine translocation (TAT) pathway signal
                     sequence domain protein"
     gene            complement(<18189..18563)
                     /locus_tag="H9199_RS25890"
                     /pseudo=""
     CDS             complement(<18189..18563)
                     /locus_tag="H9199_RS25890"
                     /inference="COORDINATES: protein motif:HMM:NF022853.4"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="protein-disulfide reductase DsbD
                     domain-containing protein"
                     /name="protein-disulfide reductase DsbD domain-containing
                     protein"
     gene            complement(18568..>18696)
                     /gene="cutA"
                     /locus_tag="H9199_RS25895"
                     /old_locus_tag="H9199_25620"
                     /pseudo=""
     CDS             complement(18568..>18696)
                     /gene="cutA"
                     /locus_tag="H9199_RS25895"
                     /old_locus_tag="H9199_25620"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004201171.1"
                     /GO_process="GO:0010038 - response to metal ion [Evidence
                     IEA]"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /pseudo=""
                     /codon_start=1
                     /transl_table=11
                     /product="divalent cation tolerance protein CutA"
                     /name="cutA"
     gene            18761..19465
                     /locus_tag="H9199_RS25900"
                     /old_locus_tag="H9199_25625"
     CDS             18761..19465
                     /locus_tag="H9199_RS25900"
                     /old_locus_tag="H9199_25625"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:YP_005221000.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="IS6-like element IS26 family transposase"
                     /protein_id="WP_001067855.1"
                     /translation="MNPFKGRHFQRDIILWAVRWYCKYGISYRELQEMLAERGVNVDHS
                     TIYRWVQRYAPEMEKRLRWYWRNPSDLCPWHMDETYVKVNGRWAYLYRAVDSRGRTVDF
                     YLSSRRNSKAAYRFLGKILNNVKKWQIPRFINTDKAPAYGRALALLKREGRCPSDVEHR
                     QIKYRNNVIECDHGKLKRIIGATLGFKSMKTAYATIKGIEVMRALRKGQASAFYYGDPL
                     GEMRLVSRVFEM"
                     /name="IS6-like element IS26 family transposase"
     gene            complement(19499..19855)
                     /locus_tag="H9199_RS25905"
     CDS             complement(19499..19855)
                     /locus_tag="H9199_RS25905"
                     /inference="COORDINATES: protein motif:HMM:NF012920.4"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="S24 family peptidase"
                     /protein_id="WP_004199403.1"
                     /translation="MGFPSPATDYQENRLSLDQHCNTGAPGVFFFRSDTYSFREGIKPG
                     ALLIVDFGGTPVDGSLVLCVLEQEFRIMRLRLHPKRCLQELDKLDNFRAIPDDDEDGLE
                     VRGVITHIVALLQS"
                     /name="S24 family peptidase"
     gene            complement(19858..20097)
                     /locus_tag="H9199_RS25910"
                     /old_locus_tag="H9199_25630"
     CDS             complement(19858..20097)
                     /locus_tag="H9199_RS25910"
                     /old_locus_tag="H9199_25630"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001549892.1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="hypothetical protein"
                     /protein_id="WP_001549892.1"
                     /translation="MPRHYEIDSAWRASIKREPNGRQTVTTEAFVSQLALINFHWSCRQ
                     ANQWIETYVTVFKDISTQEGENRTFMLFNPNGGR"
                     /name="hypothetical protein"
     gene            20199..21257
                     /locus_tag="H9199_RS25915"
                     /old_locus_tag="H9199_25635"
     CDS             20199..21257
                     /locus_tag="H9199_RS25915"
                     /old_locus_tag="H9199_25635"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000343765.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="ISL3 family transposase"
                     /protein_id="WP_241408387.1"
                     /translation="MDEKSLYAHILNLSDPWQVKSLSLDENAGSVTVTIEIAENTRLAC
                     PTCGKSCSVHDHRHRKWRHLDTCQFTTIVEADVPRIMCPEHGCLTLPVPWAGPGSRYTL
                     LFESFVLSWLKISTVDAVRKQLKLSWNAVDGIMTRAVKRGLARIKKPLSARHMNVDEVA
                     FKKGHRYITVISDRDGRALALTDDRGTESLAGYLRTLTDGQLLAIKTLSMDMNAGYIRA
                     ARIHLPSAVEKIAFDRFHVAKQLGEVVDKTRQNEHPHLPVESRHQAKGTRFLWQYSDKW
                     MTESRQEKLMWLRAQMKLTSQCWALKELAKDIWNRPWSEERRSDWQRWLALAANSDVPM
                     MKNAAKTIGKGV"
                     /name="ISL3 family transposase"
     gene            complement(21282..24287)
                     /locus_tag="H9199_RS25920"
                     /old_locus_tag="H9199_25640"
     CDS             complement(21282..24287)
                     /locus_tag="H9199_RS25920"
                     /old_locus_tag="H9199_25640"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_032495017.1"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /codon_start=1
                     /transl_table=11
                     /product="Tn3-like element Tn3 family transposase"
                     /protein_id="WP_001143760.1"
                     /translation="MPVDFLTTEQTESYGRFTGEPDELQLARYFHLDEADKEFIGKSRG
                     DHNRLGIALQIGCVRFLGTFLTDMNHIPSGVRHFTARQLGIRDITVLAEYGQRENTRRE
                     HAALIRQHYQYREFAWPWTFRLTRLLYTRSWISNERPGLLFDLATGWLMQHRIILPGAT
                     TLTRLISEVREKATLRLWNKLALIPSAEQRSQLEMLLGPTDCSRLSLLESLKKGPVTIS
                     GPAFNEAIERWKTLNDFGLHAENLSTLPAVRLKNLARYAGMTSVFNIARMSPQKRMAVL
                     VAFVLAWETLALDDALDVLDAMLAVIIRDARKIGQKKRLRSLKDLDKSALALASACSYL
                     LKEETPDESIRAEVFSYIPRQKLAEIITLVREIARPSDDNFHEEMVEQYGRVRRFLPHL
                     LNTVKFSSAPAGVTTLNACDYLSREFSSRRQFFDDAPTEIISRSWKRLVINKEKHITRR
                     GYTLCFLSKLQDSLRRRDVYVTGSNRWGDPRARLLQGADWQANRIKVYRSLGHPTDPQE
                     AIKSLGHQLDSRYRQVAARLCENEAVELDVSGPKPRLTISPLASLDEPDSLKRLSKMIS
                     DLLPPVDLTELLLEINAHTGFADEFFHASEASARVDDLPVSISAVLMAEACNIGLEPLI
                     RSNVPALTRHRLNWTKANYLRAETITSANARLVDFQATLPLAQIWGGGEVASADGMRFV
                     TPVRTINAGPNRKYFGNNRGITWYNFVSDQYSGFHGIVIPGTLRDSIFVLEGLLEQETG
                     LNPTEIMTDTAGASELVFGLFWLLGYQFSPRLADAGASVFWRMDHDADYGVLNDIARGQ
                     SDPRKIVLQWDEMIRTAGSLKLGKVQVSVLVRSLLKSERPSGLTQAIIEVGRINKTLYL
                     LNYIDDEDYRRRILTQLNRGESRHAVARAICHGQKGEIRKRYTDGQEDQLGTLGLVTNA
                     VVLWNTIYMQAALDHLRAQGETLNDEDIARLSPLCHGHINMLGHYSFTLAELVTKGHLR
                     PLKEASEAENVA"
                     /name="Tn3-like element Tn3 family transposase"
     ARG             248..1104
                     /name="blaTEM-1"
                     /gene="blaTEM-1"
                     /gene_name="broad-spectrum class A beta-lactamase TEM-1"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     ARG             15698..16506
                     /name="blaNDM-5"
                     /gene="blaNDM-5"
                     /gene_name="subclass B1 metallo-beta-lactamase NDM-5"
                     /tool="amrfinderplus"
                     /drug_class="BETA-LACTAM"
                     /identity="100.0"
                     /coverage="100.0"
     Typing          complement(5460..6331)
                     /name="IncX3"
                     /typing="replicon"
                     /tool="MOB-suite"
                     /identity="100.0"
                     /coverage="100.0"
                     /evalue="0.0"
ORIGIN
        1 tcatcagctc agtattgccc gctccacggt ttataaaatt cttgaagacg aaagggcctc
       61 gtgatacgcc tatttttata ggttaatgtc atgataataa tggtttctta gacgtcaggt
      121 ggcacttttc ggggaaatgt gcgcggaacc cctatttgtt tatttttcta aatacattca
      181 aatatgtatc cgctcatgag acaataaccc tggtaaatgc ttcaataata ttgaaaaagg
      241 aagagtatga gtattcaaca ttttcgtgtc gcccttattc ccttttttgc ggcattttgc
      301 cttcctgttt ttgctcaccc agaaacgctg gtgaaagtaa aagatgctga agatcagttg
      361 ggtgcacgag tgggttacat cgaactggat ctcaacagcg gtaagatcct tgagagtttt
      421 cgccccgaag aacgttttcc aatgatgagc acttttaaag ttctgctatg tggtgcggta
      481 ttatcccgtg ttgacgccgg gcaagagcaa ctcggtcgcc gcatacacta ttctcagaat
      541 gacttggttg agtactcacc agtcacagaa aagcatctta cggatggcat gacagtaaga
      601 gaattatgca gtgctgccat aaccatgagt gataacactg ctgccaactt acttctgaca
      661 acgatcggag gaccgaagga gctaaccgct tttttgcaca acatggggga tcatgtaact
      721 cgccttgatc gttgggaacc ggagctgaat gaagccatac caaacgacga gcgtgacacc
      781 acgatgcctg cagcaatggc aacaacgttg cgcaaactat taactggcga actacttact
      841 ctagcttccc ggcaacaatt aatagactgg atggaggcgg ataaagttgc aggaccactt
      901 ctgcgctcgg cccttccggc tggctggttt attgctgata aatctggagc cggtgagcgt
      961 gggtctcgcg gtatcattgc agcactgggg ccagatggta agccctcccg tatcgtagtt
     1021 atctacacga cggggagtca ggcaactatg gatgaacgaa atagacagat cgctgagata
     1081 ggtgcctcac tgattaagca ttggtaactg tcagaccaag tttactcata tatactttag
     1141 attgatttaa aacttcattt ttaatttaaa aggatctagg tgaagatcct ttttgataat
     1201 ctcatgacca aaatccctta acgtgagttt tcgttccact gagcgtcaga ccccgaaaaa
     1261 ggctgtacgg gatcctgaat gcgatgcgac acagtgtctc aaacggaaat gcggaggcac
     1321 ttaacagcaa gatcaggctg ctgaggataa aagccagggg ataccgaaac cgggagcgct
     1381 ttaaactggg ggtgatgttc cactacggaa agctgaatat ggcgttctga gccttcccac
     1441 catgatcggg gaagacccat gcatatacag tataaagaat cagttttatt cttcaacaca
     1501 ctgtttatta tgttgtaact actccctacc ttcaggttca tggttcattt tgttaacggt
     1561 ctgttgcttc acagctttgc tgatagtcgc ccggctacaa cccagcactt tttgaatctg
     1621 gctccaggag ctgccgctcg caatcagcct gtttatggcg tcatagcgag actgattaac
     1681 ctggcggcct ttatacttcc cttccctttt cgccctggcg atcccctgct gctgccgttc
     1741 ccggcgctgt tcatagtctc gcctggcgac ggcggccagc atatccagca acatatcgtt
     1801 tatggccgaa aacattcggc tgtcaaaatc attgtgaccc gatgcgagcc aggttgtcgg
     1861 aacgttgacg gccacaaccc ggatatcttt ctgccggatc attttcttca gtgtgttcca
     1921 gtcctcccct accaggcgtg aaagcctgtc cacatcctct accagcaaga tatcgttttg
     1981 ctgacaatct ttcaggagcc ggaacaactc agggcgttca agcttagaac ctgattcatt
     2041 ttcaatgtag tagttacaga tgctcaggcc gcgctcgatg gcgaaggtat ttatcgtgtc
     2101 cagggcgcgt gttgcatcct gttcagtcgt ggatgcgcgt aagtaagctc tgacaaagcc
     2161 tttcggtact gtttgagtca ttatagggaa ccagttcatt ttgagttaac cagacacacc
     2221 catacagtac ccatttcagt tggttcaggg aaggcacact caaaaagaac cagcaaacag
     2281 accccagccc tatagtgaca acgtcacact aaaaatttac aacataaaga tgatgtaaag
     2341 acacaccaag atttacacca taaagcgcac ataaagacac agcaacattt accatgtaaa
     2401 gacaccataa agataaatat atctttattt gtgctttaca tggtaaagcc attgcattat
     2461 aaagacactg taaagacaaa agtatcttta cgaaaaacac accatgtaaa gacattcata
     2521 tctttacatg agctttacaa cataaagaga gggattctga aatgggtaaa atcttgcttg
     2581 tcgtatcaga taaaggtggg gtaggcaaaa gcacctacgt ggctaacaca ggctcaatgc
     2641 tggtcaacaa aggtaagtcg gtaattatcc tgaagacaga taaaaaccac gatctgttga
     2701 gctggaacga aaagcggaca gataacggct tactcactat cccggttcac gcagcttacg
     2761 gaaacgtcag caacgaaatt aagcgcctta gtaagctgtg tgaagttctc attgtcgatt
     2821 gccccggcca cgacagccag gagttccgta gcgccctgac agtatcagat atcgtggtga
     2881 cactggttaa gccgtcctct gatttcgaaa gcgaaacact gaccagtgtt acagagaaaa
     2941 tccgcaccgc tcagaaagct aacgcagctc tggaaccgtg ggtgctgttc accagaatca
     3001 actcagcgaa accccgccac agaaaagcgg ccattgatct ggataaatta ctgcgttcgg
     3061 acaacatctg gattcaacct ctgaaaaccc ggatatccga gctggatgtg tatgaaagcg
     3121 cctgtaatga aggggcaggg gtacatgacg ttagccgggc atcgagcctt tcaacagcga
     3181 aagcacagat tgaacttgtg gcacaggaaa ttggcatttt atagaaatat caacaatatt
     3241 catcgaaatc tttacattgt aaatacacca taaagatact atgatattta caattaatgc
     3301 ataccgtaca aggggaaatt ttcatggctt taaaactaaa ccgcccgaac atcgatgaat
     3361 ctcagcaacc agcaacaaac gcagaaaccg cgcgttttat ctccggcgct accagagcgc
     3421 ctgtagcggg taaaccaaag ttgatgaact tcagactgcc agcgtacttt gaggagatcc
     3481 tggaagcgga ggcgcagaga acaggccaga gcaagacaac cgttctaaag gcagcgctgg
     3541 ccgcattcga taacctggac gagaacctga aaaaccactg gctgcttgaa tctgcaaaat
     3601 tagggtagcg ttatggctaa gaaaaagaga tatgttgtga tggttagaga taaaccaaat
     3661 acagcggcaa tcagcgatta ttagcctggt tagtatggtt cgctaacagg cataataagg
     3721 ccgttgccta tgactgcgga gaatggattg tcgaaccatc acattggtta agaattggaa
     3781 atccaaaata gaaagaaacc taaggaaaga aaaatgttca tattcagata tattaaaact
     3841 cttattaata tctacttgtt atacatccaa ccgatattgg ggatgttcct tataggtata
     3901 ggcttatggg ggttctatgc acctgatgag ggaacttgta ctaatctcaa tattgagtta
     3961 tgcgctgtat cagctattga tgttctgaag cctgctattt ttgtattttt aggcattatt
     4021 accgttgccg gatggtactt taccgaactt cagccgaagc taagggggga gggcaagtat
     4081 atgaaggtaa aaacaggtgt aaaaccggaa gatttcgtta agtaaaaacc gagcctaaag
     4141 acgttaaccg tgggggattt atgaataaat catggcttga acaacaggtg caaaatgaaa
     4201 aattaaaaaa agtacaggaa gagaaaaaag atggcactat ccaaaaagga ttgtacaggg
     4261 ttcgtataaa agacaaatac aggtgggatt tgtgggaaaa tgatttcaga gttgttattg
     4321 cttattcgaa agatgatgca gagctaaaat ttacagaaat gacaggtttt aatgagcatt
     4381 actatataga aagcattgaa aaaatagtgc tttcagatat agaaaaaatc ttactggaaa
     4441 actgaaaaga tagttatcca gaggtttagt taaataatgg cgtcagtttt tcaaccagta
     4501 gcagatcgct taaaccgtct aaagaaacaa cttctatacc agaatcaaca agtgaatcaa
     4561 ctccacatac ttcaccgaag ccgataacca taatcggctt tcggtctatc aaatcaaaaa
     4621 tcaccaaagg caatattaca ctgttaatcg cttcaaactc ctgaaaaaac atttcagagc
     4681 cgtattcgct ggcaggaaaa agaatctcac ttaatctcaa accataaaaa atatggtagt
     4741 gttctttaag gttatccttt aaaatattaa cagccttaga atatttttcg ttaataaact
     4801 ctttaacctg atatttcata actctctcca acaagaaccg actgtaggtc accgggcaaa
     4861 cgttgcggaa tggcgtcaga gacgtcattt tgcggcgttt gccctatcct gcatcgcagt
     4921 gaaaagaact cgcctcgtgc gctatgatta accgatgata aaaggctgaa agaagcactg
     4981 caagccgact ggataacatt gttgcttcac ggctgatcat cattggttgc ctcagtgcta
     5041 gtgtgctttg catcaggaac cagaagacga taccacggca tttttttgtt aagcagctcc
     5101 atcaggggag tggcaaacaa actcaatccc cacagcgtta cgattactgg aatcgtgaaa
     5161 ttttgcggcg tccagaactg gcgctcaagg tggaaccatg taacaacaca gagcattcca
     5221 ccaatccaga aaatagcttt actgaaagcc cccaggactg ccagagaaat aacagagact
     5281 aaatgcagtg cgccagccgt agcaagacgt agataaaacc agaaccattt agcgtgccgg
     5341 ataaccgggt taccgttcgt ttctcgcaat cgttttttac gttcccggat gatttctttt
     5401 ttcagcttac ttcgttcggc tccctgcgga aactcatata ttttagccat gttttgcctc
     5461 acttattctt ttttggtgga acgactttgt caaactcctc taaaaatgcc atatcatctt
     5521 ccgaaaagga tgaggatttt tcatttatac taaactcaaa tctaagcatg tgagccattc
     5581 tccctttttt cccaacaaca gagaaagata actgatttat ttccgttttc tcaattatct
     5641 cattaatgct tttattgata acatcacgaa caaaaaatga gtatttagga tacttatatt
     5701 tcttctcccc ttcctcaata gtataaagtc ccatttcctc ttttaaatca tccacggata
     5761 tatcaaaaga tttttttgaa ctattctgac tgtaatattt cctaatgact tgataaaggt
     5821 ttgttgagtt tacactgttc aacaacacaa ctgatttcaa tacctgagtg gtatatctat
     5881 tttcagaacc aatcaactta gaaaaatatc gcttagctgt atttgtgaat tttatccgta
     5941 cagttgcaag atgatcgtaa taggcacaga attctgttaa gtttaaatcc aagcgatcag
     6001 gtattttatt cttagatgat agtatcccaa gttcatcagc caaatttttt aaatcatctc
     6061 tgtttaaaac taacgtagtt gaagaaagaa ctttagctcc ctctttcaga gctgcataag
     6121 aggcatattt atctaaagaa gtagcttttg aaaaaaagtc agcatcaacc tccaaaatat
     6181 catcatctaa catttccttt gtatcaatct ggcaaagagc cagaaaaagc actctttttg
     6241 ctgaaaggga aagggatgca agagttaccc caacttcatt tctatgtcta actttcgtta
     6301 atcccgttac tgtcttcacg ataagcctca tataaccttt cctatgtagg caaatcataa
     6361 ccccacaaag gttgtaattc aagacaacaa tacaaccttt aattaaaaaa cctctcacct
     6421 ttagatatga agatctgagg atcttcatat ctaaagatag caacaaccgc atgtttcact
     6481 tgatgttcag tcaaactgtg gaaaccgtta aaaatcttct caccttacgt gaaaaatcct
     6541 ctcatcttta gtgaaaaatc taactacctt aacttaaaaa tcttctcacc ttacgtgaaa
     6601 aatcctctca ccttacgtga aaaatcctct cacctttagc aatttttttc cataattttc
     6661 aggtaattga agcgagctaa gtttttaagt ttttaagatc aagaagaaaa tataaggctt
     6721 ttaatgcaca gcgtctgtgg ataactcagc ataaatccag aggatagatc cgtctggcct
     6781 ccctgagcac tgcaccacca aaaattgagc aaatattaac cttagcgcgt aagtgctcta
     6841 ttgaaacccc gtggaaattc cgcttcctcg ctcactcgcg ggcttcgccc tgtcgttcgg
     6901 ctgcggcgag cggtgtaatc tctctaaaag atccagacgg gatccttttc cgatccaatt
     6961 cttaaatgct ctcaaaagcc ctcagaggcg ttttaaccgc tttaacccgg tcatggttca
     7021 acggagcggg taaaatgcgc ttagaacgtc atacagctcg tttttaacct gatccctaat
     7081 cagggggtat aacagaggcg gccaaaaaat ccggccttgc tcgtcagagt atctaccgcg
     7141 cattatcccc gaacggaaac ccgaccatca caacacttgc acagcttgca gcagtagccg
     7201 ggttacagtt cactctcagt aagcccaacc actaaccttt cagacaagcc cctcataccg
     7261 gggggattat ttcttacgcc agcaaaattt cacgaccggc gaggatggcc aagtgttttt
     7321 tgctggcaat tttcgtgcag cagctggcgc ccggattcat tttttgctgt caggcatcaa
     7381 tcggtttcag caacccgccc cgtaattcgc tgctaacgca tctcataacg cgcagataca
     7441 gcgccccgcg ccagtgtttc acactgaccc ggcgtaccgt tcgcaagctc acgcgctaac
     7501 tgcgacaggc taaacatcgt ctgatagtca gaaattggcc tggcaggggt gaggggggtt
     7561 atcgctctca ttcgggcttg ttggttcgcc agtcctggcg aacgtctccg gcgcgatgtt
     7621 acgacagcgc attatgtaac tacagttcgc gcctctttcg gaaatccctt catgcgcggt
     7681 aaagcaatat acatctttat gtaatcttta caatgtaaag cattaaaaat gattccataa
     7741 ccatcatttg atggtataat gaatttgttg gttgggaatg gttccctgcc agattccaga
     7801 agcccacacg ggcgggagcg aaaaatgaat attcaggaag cattaaacgt ttttggttta
     7861 tccggtgatc tgactgaaaa ggacatcaag gcggcataca aaaaagcggc tttaaaatat
     7921 catccagacc gcaatccatt gggtgccgag ctgatgaaag cagtaaatgc tgcgtttgat
     7981 tttctcatgg ctaacattga taaaatcaat cagtttcaaa gcactgatga aaacgcacgt
     8041 tacaactacg gtgaagatct ggaaaaagtt ctgaatacgc tttccggcct tacagggatt
     8101 gtctatgaag ttattggtaa ttgggtctgg attagcggag aaactaaaga acacaaagac
     8161 attttaaagg aaatgggctg taagtgggca tctaagaaaa aacaatggtt ttaccgtcct
     8221 gaagaacaca aaagccgctg gaaccgtaaa gaacacagca ttgaagaaat tcgtgaaatg
     8281 tatggtacag cgggtaaacg taaggcgtca ggctggacac gtgtagaagc aagcgcataa
     8341 ccggaatggg ggcgaaagcc ccctagaaca tggcaaagat tgattcggag acacgttgat
     8401 gaaaaacaag accataacgg aagcggagct gataaacatt tttgaaagtt acggagccta
     8461 catttgcccg gatgagatcg aagttacagc caaagaatgc aatgaaaatg gttcagtctt
     8521 gcaccgtggc ttaaacgcag aaggatgggc gcatcttttt gcgaaggaag aagcatatca
     8581 gcaggaatgc gaagcccagg aagctgcaag tgatgatgga cactttgatg aatagtctta
     8641 aaactgccgt aattcgattt acggcttttt tattgagttc aaaaggctga atcgatgaaa
     8701 gaacagaaaa atttctttga acggtataaa ccggtgtttg aaatcgtttg tcgaatcctg
     8761 gggaacggct ggcgtgtaaa tctgctcgat gattgccagt acaggattaa gctaacctca
     8821 cctgatttta aaaattactc tatacatatt cgaatggaga aaggaaggtt agttatcatt
     8881 ggaagcgtag atagtcgcag ctggagaagt ccttaccata cttgcacagt atcgccagag
     8941 cgtaaccctg tagaaatcgc cgccgatatt gaaaagaaaa tcctgtcgga tgctttagat
     9001 aatgtagata tggcgcgaga gtatgaacaa cagttacagc aaaaacgcga gaaaaaactg
     9061 atcctgaaag gaatgctatc tcgtttagtg catcttgaaa gctggcatgg gacattgacc
     9121 gggtttaaag ttgagaatgg gttagatggt aacgtatcag aacggggcga cggatatgaa
     9181 atggtaattc gtggcctgag tgtagatcag ctcataaagg tagcggggtt tattaaacag
     9241 ctatgaggca aaaaatgaat gaagtcctga gcgacaggaa aaacaaaggt aatgtaacat
     9301 acaggattgt tgtgtctgaa gatgcaacac gtttgtttat tgaacttgaa aaactgatga
     9361 aggtacgctc taaagaagcg gataaaaaaa caactaaaaa gattgttttc caaaaatcat
     9421 tttattacga agaattctcg aacgttaaag atgaaattga tgatccaatt ttattgaaat
     9481 tctatacaga tactattgtg aaggtacaaa atcatgagtt ttaagccaac acctgaagag
     9541 gtgaaacaag cacgtattaa agctggcttt acgcagcagg aagccgctga acggtttggt
     9601 tttacgttat cagcctggca agccaaagaa acatccggta aaacgtctcg tggtttagcc
     9661 gctggtacgt atgaattact tttgctcctg gctgatgaac atccagatta ccagctcgtt
     9721 aagagagaaa aaaatcagga taaagtgact aaataaattg cattaccatc atatgatggt
     9781 ataatttatt tgtaggtcgg gaatagttcc ttaccatgat ccagtagccc aaacgggcgg
     9841 gagactaaaa tgaacacgta tgttatcact ttccaggctt taaacactaa gaaagaaaaa
     9901 atcacctgct ctgcttttgt ccattcagaa actctcttcc ttgccgttca ttctttcgaa
     9961 gataaaaatc gcggtcgtgg ttatgttatc acgtctgtta gtgaattgtt gtccgaggaa
    10021 ctgacggcga aaaattccct caagaaaaat attaactttt ggtttaatga gtgtggttta
    10081 agtaaatctg aggttataaa cgaagtaatt aactggaaga atttcgcata tacccttaaa
    10141 gaactggagg aagccaaaaa tgaagcgata agagaactgc ggagttaatc aattaggggt
    10201 ggtatcaggt tgtggaggca acctgatacc gtgacactca attccctcgc gaggaatata
    10261 aaatgtcgga acgcatgtta tcagcaatac agactgttga aaagggtggg cgtccggttt
    10321 ttcccttgat gccattctct gcttttcctg agtacatggc attactcaga aaagccctgg
    10381 aaaagaaaga aacaaaagca ctgatagaaa aacaggaggt gctatgaaaa aacaggagtt
    10441 tttagatttt atcagtgcag aacagaggcg gggagctgtc cggttttcgc tgggatttaa
    10501 cagcaaaggg gaaattgtat tgcactggac taacgaggcc gggttaagag tctggagtat
    10561 actaagcggt aacaggggaa aaagtcccag ccgggcaaac cgggaaagaa tgagtaacct
    10621 ccgccgctgg ctccatgatg cccggcaggg catggaaggc gacacaccag aggcagaata
    10681 aaattcccgt tcctgaatcg ccgaagccct cccgtttacg ggaggtgctt tttttgtata
    10741 ttccgtaaaa cagcgctcgc gccccctgcc aggccattcg cgtagcgaat ttatttccgc
    10801 ccaagttagc cgcgaatccg ttgtctccgg tcgcagacgc accagatcac agccacgata
    10861 gcctttcatt ttttgcattt cgatggacgc tgaagcacaa tttatgtgtg gaggtagttc
    10921 actgcgatgc cggaaggacg ttcacttttc agcaatgaac ggaccagcac tgaaacctgt
    10981 actttgccca gcttcaggga gccagcggtc cggatcattt cgtcccactg aggggttcta
    11041 gggattttcc gtccaaaaac gacaaagtgc tctggaggcc ccgccgtctg tggcctccag
    11101 aggggtatta cttttttcga gatccctatt tgggctctgt ttgagtaaga tttagtcttt
    11161 ttgggctaaa tccatggcat tcgaagaacg tgtccaaatc ttgtccgagg cagaacaaga
    11221 tgagttatat ggaccccccg ctttcacctc cgccgaccaa cgcttctttt tctcgctgaa
    11281 cgataaggaa ctggcgatcg ctaaaagcct ccgtcatcgg ggccagcgtt acatgctggt
    11341 ggtactgctg ggctatttca aagccaagcc ggtggtgctg aatcccggct ttcatcagat
    11401 caagcaggac ctcaaatacg tttatcaaac cgttctacca ggcccaggct gtagaccctt
    11461 taatctcacg ccaaaagaga acgaacggat ttaccaacgt gttttccagc tctgcaacta
    11521 ccagcgctgg aatgtcaaag accatggagc ggcgttgaga gattacttat cccagcaagc
    11581 cagagcctgg acagcgccta ggcacctctt cgatgcggcc aatgaatatt gttcggggca
    11641 gaagatcgca atccctgcct acagcacgct gcaaaagatc atcagtcagg tggtgggaga
    11701 cgaacaggaa cacatggccg cgcaccttga gcgtgcaatg tcacgcggtc ttaagcaagc
    11761 actggcggag ctcgtgaacg gcacaggtcc actgccgttc cgacagttgc gacaatcggc
    11821 tcgtaacttc accggaaccg agttggagaa agaactgatt gtctatcgcc atatccagca
    11881 ttggatgccg gaagtggatc tgctgttgag cacgctatca ctgtcgcaga aaaatctgca
    11941 acacctggca gagaaagtcg actactacgg tgccaaactg aaacgtcaaa ccgtaggcag
    12001 ccaatggctg tatttattgt gctatcttca aacgcgatgg cagcaagcgc tggaacgtat
    12061 tgccgatggc tttgtgcatc atgtcagaca gaccaaacag aaggcaaagg attatgcgca
    12121 ggaagcggtg tttaaggatt ggcaaaaagc agctaaaaat gtcagcaagg cagctgaagt
    12181 actgcacctg ttcattgatg acagcattga tctgcaacta ccgtttgcaa cagtaagaca
    12241 gcaagcactg agcctgctga ccaaaaggga tctggaatct gtatgtctct tcctgaacga
    12301 gcagcgacga tcggtcgatg aagccatgtg gcagtactgc gacgagaaag aaagtctgcg
    12361 gaaaggtttg ctgcgagagt tgttcctatg tctgcgcttc gaaggctgcg acggcaccca
    12421 gcacttagcg gccgccttgg cgaaaacaca aaacgaactc aacggccagg acgctcagtt
    12481 gcaaactgcc gacaccagac tcctttccaa aaaatcacgt gaattcctgc tggatggtga
    12541 agggaatatc ctgatcgatc gttatgagtg gttcctctat caacagattc ctgatcgcct
    12601 gaatggccag ctgacgctgc ctgatatcac taaataccgg gcactcgacg ccgacctgat
    12661 cgacggggaa cattggcgaa aaaacaaata tacgctgctt caacagagcc attttacaaa
    12721 attagcggag gagcctgaaa agctgatcaa acagatggcc atggaattgg atacccgttt
    12781 gtacgaagtc ggcgaatatc ttgaacagga agacaaccgg aatatcatct tgcgtaatcc
    12841 gcagggtaaa cgcttctggc gcctgccttc ggccagcaaa catcatctgg tcaacaatcc
    12901 cttcttccag caaattccca caacggggat tgcggatgta ctgcgcatgg ttgatcgtga
    12961 caccggtttc attgactgct tcgctcatgt gctgggttcc caatccagaa gccgttccca
    13021 tgaatatgac ctgttggcaa ttctggtcgg caatgcaacc aatcaaggca tttacggcat
    13081 ggcacagatc tctgatcgta cctatgatca gctcagcact atccaggcga actatcttcg
    13141 cctggaaaca ttgaatgctg ctaacgacaa catcaataac gcgacagcca agctacccat
    13201 cttccggtac tacaacatcc aggaagatgt gatccacgcc agtgccgatg gtcaaaagtt
    13261 cgaagcccgg cgcgagacct tcaaaacccg ttattcgtcg aagtactttg gcactcaaaa
    13321 aggtgtttct gccatgacct tgatcgccaa tcacgctgcg atcaacgcca gagtgatcgg
    13381 cgccaacgaa catgaatcgc actacatctt tgatttgttg atgagcaata cgtcagacat
    13441 cattccggat gtgctctcaa ccgataccca tggggtgaac catgtgaact tcgcgttact
    13501 ggatctgttc ggataccagt ttgccccacg ctatgcccag gttggcaaag tgatcaatga
    13561 catgtttgat gtcaaggaag acaaagaaca ccgaattcag ctgtgcttaa aaaagccaat
    13621 caatacccat cgtattgcgc agcactggga taccatccaa cggattgcag tatcacttaa
    13681 gcagcggaaa acaacgcaag ccaccttggt gagaaagctc tcggagtaca agcgcaatca
    13741 cccgctgctg gaagccctga cggaatacaa tcgcctggtg aaagcgaatt atctactgtg
    13801 ctacatcgat gatgccagtt taagaaacta tgttcagcgc gcgctgaacc ggggagaggc
    13861 ctatcaccaa ctgcgtcggg ccgtgagcag cgtcaatggg gatcagttcc ggggcagttc
    13921 agacgaagaa atccagctat ggaatgagtg cgctcgcctg gtcaccaatg ccatcgttta
    13981 cttcaactcc aggatactca gccagctgtt gaccagcttc gaataccaag gagataccaa
    14041 gagaatagat atcgtcaaac aggcatcccc tgtggcctgg cacaacatta acctcaaggg
    14101 gacttaccac ttcgaattga gcgaaaaatt gccagatctg gaggagctta tgcgctcaat
    14161 cgagggatat ttacccgtca gcgaaaagta atacccctct ggaggccacg gacggcgcgg
    14221 cctccagagc actttgtcgt ttttggacgg aaaatcccta gaaccccatt atctaaaaat
    14281 acttaattgt cttttaacgt cgctaaattt taaataaata agtgaagagt gttagggaag
    14341 gtgcgaataa gcggggaaat tcttctcggc tgactcagtc atttcatttc ttcatgtttg
    14401 agccgatttt ttctcccgta aatgccttga atcagcctat ttagaccgtt tcttcgccat
    14461 ttaaggcgtt atccccagtt tttagtgaga tctctcccac tgacgtatca tttggtccgc
    14521 ccgaaacagg ttggccagcg tgaataacat cgccagttgg ttatcgtttt tcagcaaccc
    14581 cttgtatctg gctttcacga agccgaactg tcgcttgatg atgcgaaatg ggtgctccac
    14641 cttggcccgg atgctggctt tcatgtattc gatgttgatg gccgttttgt tcttgcgtgg
    14701 atgctgtttc aaggttctta ccttgccggg gcgctcggcg atcagccagt ccacatccac
    14761 ctcggccagc tcctcgcgct gtggcgcccc ttggtagccg gcatcggctg agacaaattg
    14821 ctcctctcca tgcagcagat tacccagctg attgaggtca tgctcgttgg ccgcggtggt
    14881 gactaggctg tgggtcaggc cactcttggc atcgacacca atgtgggcct tcatgccaaa
    14941 gtgccattga ttgcctttct tggtctgatg catctccgga tcgcgttgct gctctttgtt
    15001 cttggtcgag ctgggtgcct caatgatggt ggcatcgacc aaggtgcctt gagtcatcat
    15061 gacgcctgct tcggccagcc agcgattgat ggtcttgaac aattggcggg ccagttgatg
    15121 ctgctccagc aggtggcgga aattcatgat ggtggtgcgg tcaggcaagg cgctatccag
    15181 ggataaccgg gcaaacagac gcatggaggc gatttcgtac agagcatctt ccatcgcgcc
    15241 atcgctcagg ttgtaccaat gctgcatgca gtgaatgcgt agcatggttt ccagcggata
    15301 aggtcgccgg ccattaccag ccttggggta aaacggctcg atgacttcca ccatgttttg
    15361 ccatggcaga atctgctcca tgcgggacaa gaaaatctct tttctggtct gacggcgctt
    15421 actgctgaat tcactgtcgg cgaaggtaag ttgatgactc atgatgaacc ctgttccatg
    15481 gctccagatg acaaacatga tctcatatca gggacttgtt cgcaccttcc ttagagaaat
    15541 ttgctcagct tgttgattat catatggctt ttgaaactgt cgcacctcat gtttgaattc
    15601 gccccatatt tttgctacag tgaaccaaat taagatcatc tatttactag gcctcgcatt
    15661 tgcggggttt ttaatgctga ataaaaggaa aacttgatgg aattgcccaa tattatgcac
    15721 ccggtcgcga agctgagcac cgcattagcc gctgcattga tgctgagcgg gtgcatgccc
    15781 ggtgaaatcc gcccgacgat tggccagcaa atggaaactg gcgaccaacg gtttggcgat
    15841 ctggttttcc gccagctcgc accgaatgtc tggcagcaca cttcctatct cgacatgccg
    15901 ggtttcgggg cagtcgcttc caacggtttg atcgtcaggg atggcggccg cgtgctgttg
    15961 gtcgataccg cctggaccga tgaccagacc gcccagatcc tcaactggat caagcaggag
    16021 atcaacctgc cggtcgcgct ggcggtggtg actcacgcgc atcaggacaa gatgggcggt
    16081 atggacgcgc tgcatgcggc ggggattgcg acttatgcca atgcgttgtc gaaccagctt
    16141 gccccgcaag aggggctggt tgcggcgcaa cacagcctga ctttcgccgc caatggctgg
    16201 gtcgaaccag caaccgcgcc caactttggc ccgctcaagg tattttaccc cggccccggc
    16261 cacaccagtg acaatatcac cgttgggatc gacggcaccg acatcgcttt tggtggctgc
    16321 ctgatcaagg acagcaaggc caagtcgctc ggcaatctcg gtgatgccga cactgagcac
    16381 tacgccgcgt cagcgcgcgc gtttggtgcg gcgttcccca aggccagcat gatcgtgatg
    16441 agccattccg cccccgatag ccgcgccgca atcactcata cggcccgcat ggccgacaag
    16501 ctgcgctgag ccatggctga ccacgtcacc cccaatctgc catcgcgcga tttcgatgtg
    16561 acagaggcgt tttatgcgaa gctgggcttt gcgacgagtt ggaaggatcg cggctggatg
    16621 atcctgcagc gcggcggttt gcagctcgaa ttcttcccct atcctgacct cgacccagct
    16681 acgagctcgt tcggctgttg cctgcggttg gatgatctcg atgccatggt ggcattggtg
    16741 aacgcggcgg gagccgagga aaaaagcacc ggctggccgc gcttcaaagc tccgcaactg
    16801 gaggcgagcg gcctgaggat cggctacctg atcgatcccg actgcacgct ggtgcggctg
    16861 atccagaacc ccgactgacc gcatgcccgc gaaaatcaag atttgcggga tcagcacacc
    16921 cgaggcgctc gatgcgacca tcgcggcgcg ggcggactat gccgggttgg tgttctatcc
    16981 agcgtcgccc cgtgcggtta cgtcgaatgt cgcgggcgct ttgacatcgc gcgcagctgg
    17041 ccagatcgcc atggtcggtt tgttcgtcga tgcggatgat gctgtcatcg ccgacgcact
    17101 ggtggcagcc aagctgaacg cgctgcagct gcacggttcg gaatcgcccg aacgcgtggc
    17161 ccagttgcgc gcgcggtttg gcaagccggt gtggaaggcg ctgcccgtcg ccagcgccag
    17221 cgatgtcgca cgcgccgcag cctatgccgg ggcggcggac ttgatcttgt tcgacgccaa
    17281 gacccccaaa ggcgcgctgc ccggcggcat ggggttggcg ttcgactggt cgctgctggc
    17341 cggatatcgc ggtgccttgc cgtgggggct ggcaggcggg ctaaatccga cgaatgttgc
    17401 cgaggcgatt gcgcgcaccg gagcgccgct ggtcgatacc tccagcggcg tcgaaagcgc
    17461 gccgggcgtc aaggataccg acaagattac caatttcgcc tttgcggtgc gcttggccta
    17521 aatcgcgtcg atcaataggc gtcgttcagc gcaaagatcg gcttgcgggt gcgccactgc
    17581 cctcgggtga agtcgggaaa atctaacgtg cgattgccct cagcaatcga ttgttccgac
    17641 agaggcgtga tcgcgctcca ggccagcgcg tcgtaaatgt cgattggcat cggggccttg
    17701 gccttcagcg cctcgacaaa agcgtggatc acgaaccagt ccatcccgcc atgcccggcc
    17761 cctgccgcca gatcggcgta gcgtttccat agcgggtgat cgtatttcgc aaaccagccc
    17821 tcggcaggct cccagcggtg cggctgtggg ctcttgccct ccagatagat cgacttgttg
    17881 acgtccatcc acagcccctc ggtgccttgc acccgaaagc cgagagaata ggggcgcggc
    17941 agcgaggtgt cgtggcacag catgatcgtt tcaccattag tgcagccgat catggtgttg
    18001 accacatcac ccagtgcgaa tttcacctcg gcgttgggat gatcggcaga gccgttcttg
    18061 acgacataat catgcagccc gcgcgcctta cagccgaagc cgccagcgcc cgcttcgccc
    18121 ggcaacgcga ccttcagggt gcgggtctgc ggcgggtagc acacgccggc atcggcgcag
    18181 ccctggtact tcacggtcag ggtggtcgcg ctcgcgccgg ccgcgggcgt gccggtgagg
    18241 gtgccgagca attccttgcg gtaggtttcg acgtcgccga agaattcgtc gcggtaggcc
    18301 ttgcccttcg gcagcgccat ggtcgcgccg gtgaaggcgg catcggcctt gaccgaggtg
    18361 cggtgccggt acaggtaata gccgtcggcg atccgccagc gcacctcgat gcggtccggc
    18421 gcggtggcct gcgcggacag gacgaagacc tcgtcgaccg gcggcagttc gaagtcctgg
    18481 gcgacggccg aggtcgcggg cagcgcaagc agcagggcga gcccggccag ccagcggcgc
    18541 aggcggatcg tggatgcggt cattggctca gtttaccggt cggctctcgg cggccagcca
    18601 ttgcaggtat tcgggcaggc cggacgcggc ttcgaccgcg agcagctccg ggagttcgta
    18661 gggatgcagt tggcgcaggc gttcctgcag ggcggggggc actgttgcaa atagtcggtg
    18721 gtgataaact tatcatcccc ttttgctgat ggagctgcac atgaacccat tcaaaggccg
    18781 gcattttcag cgtgacatca ttctgtgggc cgtacgctgg tactgcaaat acggcatcag
    18841 ttaccgtgag ctgcaggaga tgctggctga acgcggagtg aatgtcgatc actccacgat
    18901 ttaccgctgg gttcagcgtt atgcgcctga aatggaaaaa cggctgcgct ggtactggcg
    18961 taacccttcc gatctttgcc cgtggcacat ggatgaaacc tacgtgaagg tcaatggccg
    19021 ctgggcgtat ctgtaccggg ccgtcgacag ccggggccgc actgtcgatt tttatctctc
    19081 ctcccgtcgt aacagcaaag ctgcataccg gtttctgggt aaaatcctca acaacgtgaa
    19141 gaagtggcag atcccgcgat tcatcaacac ggataaagcg cccgcctatg gtcgcgcgct
    19201 tgctctgctc aaacgcgaag gccggtgccc gtctgacgtt gaacaccgac agattaagta
    19261 ccggaacaac gtgattgaat gcgatcatgg caaactgaaa cggataatcg gcgccacgct
    19321 gggatttaaa tccatgaaga cggcttacgc caccatcaaa ggtattgagg tgatgcgtgc
    19381 actacgcaaa ggccaggcct cagcatttta ttatggtgat cccctgggcg aaatgcgcct
    19441 ggtaagcaga gtttttgaaa tgtaaggcct ttgaataaga caaaaggctg cctcatcgct
    19501 aactttgcaa cagtgccaca atgtgcgtaa tgacccccct gacctccaac ccgtcctcat
    19561 cgtcatcagg tatagccctg aagttatcca gcttatcgag ttcctggaga caccgcttgg
    19621 ggtgtagtcg caatcgcatg atcctgaatt cttgttccag gacacagagc accaaagacc
    19681 cgtcaacggg cgtgccccca aaatctacta tgagcagcgc accaggcttt atcccttccc
    19741 ggaaagagta ggtatcactt cgaaaaaaga atactcccgg cgctcctgta ttacagtgct
    19801 gatcgagtga cagcctgttt tcctggtagt cggttgctgg cgatggaaaa cccattttta
    19861 acggcctccg ttggggttaa aaagcatgaa tgtccggttc tctccttcct gagtggaaat
    19921 gtctttaaaa acggtcacgt aggtttcaat ccactgattt gcttggcgac aactccagtg
    19981 aaaattaatc agcgcaagct ggctgacaaa ggcttctgtc gtaactgtct gacgaccgtt
    20041 cggctcacgc ttaatgctcg cacgccaggc tgagtcaatt tcatagtgtc taggcatgaa
    20101 aaacctccga tcaatatagc tgtatgcata tgggtcttcc cttgttgtgg tggctgaagg
    20161 catgataatg gtgtatttaa tcgccagagg tcaccgccat ggacgaaaag tccctctacg
    20221 ctcatattct caacctgtcc gatccgtggc aggtaaagtc cctttctctc gatgaaaatg
    20281 ccggttctgt tactgtcact attgagatcg ctgaaaacac ccggctagcc tgtccgacct
    20341 gcggtaaatc ctgttctgtt cacgatcacc gtcatcgtaa atggcgccat cttgatacct
    20401 gccagttcac cactattgtt gaagccgatg ttccacgaat tatgtgtccg gagcatggct
    20461 gcctgacgtt gcctgttccg tgggctggcc ccggaagccg gtatacgttg ctattcgaat
    20521 cgttcgttct ctcatggctg aaaatcagca ccgttgatgc tgtcaggaag caacttaagc
    20581 tcagttggaa tgcggttgac ggcattatga cccgggcagt taagcgaggt cttgcccgga
    20641 taaaaaagcc attatccgcc cgtcatatga atgtggatga ggtcgccttt aaaaaaggac
    20701 atcgttacat aacggtgatc tccgatcgcg atggtcgggc gctggcctta acggatgatc
    20761 gcggcacaga gagtcttgcc ggctatcttc gcacgctcac tgatgggcag ttgctggcta
    20821 tcaaaacgct ctcaatggac atgaacgcgg gctatataag agcagcgcgt atccacttac
    20881 ccagtgcggt tgagaaaatc gcctttgacc gcttccatgt ggcgaagcaa ctgggcgagg
    20941 tagttgataa aacccgtcag aatgaacatc cgcacctccc tgttgaaagc cgacaccagg
    21001 caaaaggaac ccgcttcctg tggcagtaca gcgataagtg gatgaccgaa tcccggcagg
    21061 aaaagctgat gtggctgcgt gcacagatga agctgacgag ccagtgctgg gcgctgaaag
    21121 agctggcaaa ggatatctgg aacaggccat ggagcgagga aagacggagt gactggcaga
    21181 gatggttggc gctggcggct aacagtgacg ttcccatgat gaaaaatgcc gcgaaaacga
    21241 taggaaaagg ggtctgacgc tcagtggaac gaaaactcac gttaagcaac gttttctgcc
    21301 tctgacgcct cttttaatgg tctcagatgt cctttggtca ccagttctgc cagcgtgaag
    21361 gaataatggc cgagcatatt gatatgtccg tggcaaagcg gggagaggcg tgcgatatct
    21421 tcatcattca gtgtttcacc ctgcgcccgg agatgatcca gggctgcctg catataaata
    21481 gtgttccata acacgacggc gttagtgacc agccccagtg tgcccagttg atcttcctga
    21541 ccgtcggtat atcgttttct tatctcacct ttttgaccgt gacagatggc tctggcaacg
    21601 gcatggcgac tttctccccg attaagctgg gtcagaatgc gccggcggta atcttcatca
    21661 tcaatataat taagcagata cagcgttttg ttgatgcgcc ccacttcaat gattgcctga
    21721 gtcagtccgg aaggacgttc acttttcagc aatgaacgga ccagcactga aacctgtact
    21781 ttgcccagct tcagggagcc agcggtccgg atcatttcgt cccactgaag gactattttt
    21841 cggggatctg attgccctct ggcaatatca ttcagcacgc catagtcggc atcatggtcc
    21901 attcgccaga aaaccgaagc accggcatca gccaggcgtg gagaaaactg gtatcccagc
    21961 agccagaaaa ggccaaagac aagttcgctg gcacctgctg tatcggtcat aatttcggtt
    22021 ggattcagcc cggtctcctg ttccagaaga ccttccagca caaagataga gtccctcagc
    22081 gtccccggta taacgatgcc atgaaagccg gaatactgat cggacacaaa gttgtaccag
    22141 gtgatccctc tgttattacc aaagtatttg cggttcggtc cggcattgat tgttctgact
    22201 ggcgtaacaa agcgcattcc atctgcagat gccacttctc ctccacccca tatctgtgcc
    22261 agtggcagcg ttgcctgaaa atcaaccagt ctggcattag cgctggtgat agtttcagcc
    22321 cgcagatagt tcgcttttgt ccagttcagc cggtgtcggg tcagtgcagg aacatttgat
    22381 ctgatcagtg gttccagacc gatattgcag gcttcagcca tcagcacggc gctgatgctg
    22441 acgggcagat catcaactct ggcactggct tcactagcat ggaaaaactc atcagcaaat
    22501 ccggtatggg cgttaatttc gagcagcaac tccgttaaat ccaccggagg gagtagatca
    22561 ctgatcattt tgctcagtcg tttcagactg tccggctcat caagactggc gaggggagaa
    22621 attgtcaacc ggggcttcgg gccagaaaca tcgagttcga cagcctcatt ttcgcaaaga
    22681 cgtgcagcaa cctgtctgta acgactatca agctgatgac ccagagattt tattgcttcc
    22741 tgcgggtctg tcgggtgccc caaagaacga taaaccttaa tccggtttgc ctgccagtca
    22801 gcaccctgta gtaatcttgc acgaggatct ccccaccggt tactgccggt aacgtagaca
    22861 tccctccgcc tcagactatc ctgcagttta ctgagaaagc agagcgtgta tcccctgcgg
    22921 gtgatatgtt tttccttgtt aatcaccagc cgtttccatg accgactgat aatttccgtt
    22981 ggtgcgtcgt caaaaaactg ccgccgtgag ctgaactccc ggctgaggta gtcacaggca
    23041 ttcagagtgg taaccccggc aggtgcggat gaaaatttaa cggtattcag cagatggggc
    23101 aggaaacgac gaacgcgccc gtactgctcc accatttctt catgaaaatt atcgtctgag
    23161 ggccgggcaa tttcacggac aagcgtgatg atttcagcca gcttttgcct tgggatgtag
    23221 ctgaacacct cagcacgaat cgattcgtcc ggtgtttctt ctttcagcag gtacgaacat
    23281 gcgctggcga gcgccaatgc agatttatcc agatccttca gcgagcggag ccgttttttc
    23341 tgcccaatct ttctggcgtc acggatgata acggccagca tggcgtccag aacgtccaat
    23401 gcatcatcca gcgccagcgt ttcccatgca aggacaaagg caaccagaac cgccatcctt
    23461 ttctgcggtg acatcctggc aatattgaac accgaagtca taccagcata acgtgcgaga
    23521 tttttcaggc gcacagccgg gagtgtactc aggttttcag catgcaggcc aaaatcgttc
    23581 agagttttcc agcgttcaat tgcttcatta aacgccggac cactgatggt cacagggccc
    23641 tttttcagtg attccagtaa agacaggcgg ctgcaatcag ttggccccag cagcatctcc
    23701 agctgtgaac gctgttcggc tgacggtatc agtgccagtt tgttccacag gcgcaacgtc
    23761 gccttttccc ttacctctga aatcaaccgg gtcagcgtag tggctccggg gagaataata
    23821 cgatgttgca taagccaccc tgtcgccaga tcgaaaagca ggccaggacg ttcgttgctt
    23881 atccagctcc gggtatataa aagacgggta aggcgaaatg tccagggcca ggcaaattca
    23941 cgatactgat agtgctgacg tatcagcgct gcatgctcac ggcgggtatt ttccctctga
    24001 ccgtattctg caagaacggt gatatcacga atcccgagct gtctggcggt aaaatgccgg
    24061 acgccggaag gaatatgatt catatcggtg aggaaggtgc ccagaaaacg gacacatcca
    24121 atttgcaggg caatgcccag acggttgtga tcacctctgc tttttccgat aaattccttg
    24181 tctgcttcat caaggtgaaa atatcgtgcc agctgaagct catccggttc accggtgaat
    24241 ctgccatagc tttcagtctg ctcagtggtc agaaagtcaa cgggcatatc ggcctccctg
    24301 cctgacgggc atttagtaac atttttccaa ccgtacgaaa tgttataaat tatcggacat
    24361 cgtaaaactg ttacattaat atgtctatta aatcgtaaat ttgtaataat agacatgagt
    24421 tgtccgatat tcgatttaag gtacattttt atgcgacttt ttggttacgc tcgggtctca
    24481 accagtcagc agtctcttga tcttcaggtc agagcactca aagacgcagg tgtgaaagca
    24541 aaccgtatat ttaccgataa ggcatccggc agttcaacag accgggaagg gctggatttg
    24601 ctgaggatga aggtggagga aggtgatgtc attctggtta agaagctcga ccgtcttggc
    24661 cgcgacactg ccgatatgat ccaactgata aaggaatttg acgctcaggg cgtggcagtc
    24721 cggttcattg atgacgggat cagtaccgac ggtgatatgg ggcaaatggt ggtcaccatc
    24781 ctgtcggctg tggcacaggc tgaacgccgg aggatcctag aacgcacgaa tgagggccga
    24841 caggaagcaa agctgaaagg aatcaaattt ggccgcaggc gtaccgtgga caggaacgtc
    24901 gtgctgacgc ttcatcagaa gggcactggt gcaacggaaa ttgc
//
